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Дисертації з теми "Cox-2 expression"

Автор: Grafiati

Опубліковано: 11 березня 2023

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1

Sun, Haipeng. "Regulation of Cyclooxygenase Gene Expression by Glucocorticoids in Cardiomyocytes." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194896.

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Glucocorticoids (GCs) are endogenous steroid hormones that regulate a number of critical physiological processes. Psychological stress increases the level of GCs in the circulating system. The biological effect of elevated GCs on the heart is not well understood. We found that GCs induced Cyclooxygenase-1 (COX-1) and COX-2 gene expression in cardiomyocytes. COX-1 or COX-2 encodes the rate-limiting enzyme in the biosynthesis of prostanoids, which modulate crucial physiological and pathophysiological responses. The present studies aim to elucidate the signaling transduction pathway and the

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2

Fritzsche, Julia. "Expression von EGFR, HER-2 und COX-2 beim Zervixkarzinom: Vergleich von Primärtumoren und Rezidiven." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-119352.

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Ziel dieser Studie war es, die Häufigkeit der Expression von EGFR, HER-2 sowie COX-2 im Zervixkarzinom zu eruieren. Dabei galt es herauszufinden, ob Unterschiede hinsichtlich des Nachweises dieser drei, möglicherweise therapeutisch relevanten Moleküle zwischen den primären, nicht vortherapierten und operierten Karzinomen und den multimodal vorbehandelten Rezidiven gab. In der vorliegenden retrospektiven Arbeit wurden 45 TMMR-operierte Primärtumoren und 28 LEER-operierte Rezidivtumoren der Universitätsfrauenklinik Leipzig (Triersches Institut) einbezogen und zusätzlich hinsichtlich der prognost

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3

Kim, Janet Heejung. "Cyclooxygenase-2 Expression in Post-Mastectomy Chest Wall Relapse." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-104942/.

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The purpose of this study was to assess the prognostic significance and clinical correlations of cyclooxgenase-2 expression (COX) in a cohort of patients treated with radiation (RT) for post-mastectomy chest wall relapse (PMCWR). Between 1975 and 1999, 113 patients were treated for isolated PMCWR. All patients were treated with biopsy and/or excision of the CWR followed by RT. Median follow-up was 10 years. All clinical data including demographics, pathology, staging, receptor status, HER-2/neu status, and adjuvant therapy were entered into a computerized database. Paraffin-embedded CWR specim

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4

Kim, Youngsoo. "Molecular characterization of cyclooxygenase-2 (COX-2) expression in murine skin carcinoma cells /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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5

Rowe, Kherie Sheheda Janelle. "Cox-2 expression : interaction of Neisseria meningitidis with human cells." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519420.

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6

Abdalla, Salem Ishtiwi. "Cyclooxygenase-2 (cox-2) expression in Barrett's oesphageal epithelium : relationship to inflammation and cancer." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418127.

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7

Lysitsa, Stella. "Evolution du lichen plan buccal et expression de la COX-2 /." Genève : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253996.

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8

Huppes, Rafael Ricardo [UNESP]. "Expressão gênica de MMP-2 e 9, TIMP-1 e 2, ATM, TP53, VEGF, COX-2 e CDH-1 no TVT canino." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/122030.

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Made available in DSpace on 2015-04-09T12:28:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-20Bitstream added on 2015-04-09T12:47:47Z : No. of bitstreams: 1 000814346.pdf: 1337951 bytes, checksum: 9ed960afb83960e3296a726e4541f251 (MD5)<br>A literatura cita que 1 a 5% dos casos de tumor venéreo transmissível (TVT) primário são metastáticos. Sendo assim, é importante estudar os mecanismos que colaborem para a invasão metastática assim como para sua implantação. Dentre estes mecanismos as metaloproteinases (MMP-2 e MMP-9) e seus inibidores (TIMP-1 e TIMP-2), assim como o ATM, COX-

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9

Huppes, Rafael Ricardo. "Expressão gênica de MMP-2 e 9, TIMP-1 e 2, ATM, TP53, VEGF, COX-2 e CDH-1 no TVT canino /." Jaboticabal, 2014. http://hdl.handle.net/11449/122030.

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Orientador: Renée Laufer Amorim<br>Coorientador: Andrigo Barboza De Nardi<br>Coorientador: Mirela Tinucci Costa<br>Banca: Rosemere de Oliveira Vasconcelos<br>Banca: Geórgia Mode Magalhães<br>Banca: Rafael Torres Neto<br>Banca: Bruno Watanabe Minto<br>Resumo: A literatura cita que 1 a 5% dos casos de tumor venéreo transmissível (TVT) primário são metastáticos. Sendo assim, é importante estudar os mecanismos que colaborem para a invasão metastática assim como para sua implantação. Dentre estes mecanismos as metaloproteinases (MMP-2 e MMP-9) e seus inibidores (TIMP-1 e TIMP-2), assim como o ATM,

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10

Laube, Markus. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-160091.

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Eine erhöhte COX-2-Expression wird bei Krankheiten wie rheumatoider Arthritis aber auch Parkinson, Alzheimer und Krebs beobachtet. Die nichtinvasive Visualisierung und Quantifizierung der COX 2-Expression in vivo mittels Positronen-Emissions-Tomographie (PET) könnte wertvolle Beiträge zur Diagnose dieser Krankheiten liefern. Zur Nutzung der PET-Technik werden geeignete COX-2-adressierende Radiotracer benötigt, deren Entwicklung auch die Identifizierung neuer, der Radiomarkierung zugänglicher COX-2-Inhibitoren als Leitstrukturen voraussetzt. Ziel dieser Arbeit war die Synthese von selektiven,

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11

Laube, Markus. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET." Doctoral thesis, Technische Universität Dresden, 2014. https://tud.qucosa.de/id/qucosa%3A28510.

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Eine erhöhte COX-2-Expression wird bei Krankheiten wie rheumatoider Arthritis aber auch Parkinson, Alzheimer und Krebs beobachtet. Die nichtinvasive Visualisierung und Quantifizierung der COX 2-Expression in vivo mittels Positronen-Emissions-Tomographie (PET) könnte wertvolle Beiträge zur Diagnose dieser Krankheiten liefern. Zur Nutzung der PET-Technik werden geeignete COX-2-adressierende Radiotracer benötigt, deren Entwicklung auch die Identifizierung neuer, der Radiomarkierung zugänglicher COX-2-Inhibitoren als Leitstrukturen voraussetzt. Ziel dieser Arbeit war die Synthese von selektiven,

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12

Scheer, Martin-Jürgen [Verfasser]. "Die Rolle der Cyclooxygenase-2-(COX-2)-Expression auf Prognose und Therapie oraler Plattenepithelkarzinome / Martin-Jürgen Scheer." Köln : Deutsche Zentralbibliothek für Medizin, 2011. http://d-nb.info/1017871841/34.

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13

Sheridan, Jared. "Partnership between the aryl hydrocarbon receptor (AHR) and RELB regulates cigarette smoke-induced cyclooxygenase-2 (COX-2) expression." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123307.

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Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lungs caused by cigarette smoke exposure; COPD is also now the third leading cause of death worldwide. Controlling lung inflammation is a priority in COPD patients, but currently-available medications offer little relief. Thus, new therapeutic targets represent a major unmet need. Previously, the aryl hydrocarbon receptor (AHR) has been shown to suppress cigarette smoke-induced inflammation. The AHR is a ligand-activated transcription factor, and well-established for its response to xenobiotic ligands. AHR-mediated

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14

Kommareddy, Madhavi. "Upregulation of COX-2 protein expression in porcine macula densa with L-NAME treatment." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6073.

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Thesis (M.S.)--University of Missouri-Columbia, 2008.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.

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15

Pacelli, Anna. "Development of a PET probe for the imaging of COX-2 expression in cancers." Thesis, University of Hull, 2015. http://hydra.hull.ac.uk/resources/hull:15192.

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The COX-2 isozyme is overexpressed in several kinds of cancer, including colorectal, lung, breast, and oesophageal cancer. High levels of COX-2 are usually associated with poor prognosis and advanced disease. Furthermore, studies have suggested that co-administering COX-2 inhibitors along with classic chemotherapy can improve disease outcome. Therefore, COX-2 is an attractive PET imaging biomarker for patient stratification. A first library of potential COX-2 inhibitors with a 5,5-diphenyl hydantoin core was synthesised and screened for its affinity for COX isozymes. This structure was chosen

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16

Benderro, Girriso Futara. "AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1350159484.

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17

Yeoh, Ann Suk Jing. "Nuclear factor kB (NFkB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is association with subsequent histopathologic changes /." Title page and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09MSB/09msby46.pdf.

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18

Carpenter, Oliver L. "Ultraviolet Light-Induced Regulation of Transcription and Translation, COX-2 Expression and Noncanonical NF-κB Activation". Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1382624015.

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19

Gu, Baoying. "Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy : effects of nimesulide." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112627.

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Wernicke's encephalopathy is a neuropsychiatric disorder resulting from thiamine deficiency (TD) and is characterized by neuronal loss, astrocytic proliferation and microglial activation. Cyclooxygenases (COX) are enzymes which catalyze the first step in the synthesis of prostanoids. COX-1 is expressed constitutively and COX-2 is the inducible isoform. Groups of TD rats and pair-fed controls were killed at presymptomatic and symptomatic stages of encephalopathy. Cresyl violet and NeuN staining showed decreased numbers of neuronal cells in vulnerable regions (medial thalamus and inferior collic

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20

Fallatah, Hafsah M. "Regulation of COX-2 expression by the BCL-3:NF-KappaB homodimeric complex : implications for colorectal carcinogenesis." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685143.

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Cyclooxygenase-2 (COX-2) is an enzyme that plays a key role in the synthesis of prostaglandin (PGE2). COX-2 has been widely investigated in cancer progression studies generally and in colorectal cancer (CRC) specifically, not only because it is regulated by various signalling pathways, but also because it is one of the main players in the inflammation/cancer link. The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-KB) is among the transcription factors that have been repOlied to regulate the transcriptional activity of the COX-2 gene. Constitutive activity of NF-KB clearly

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21

László, Csaba F. "Translation regulation of UV-light-induced transcription factor NF-kappa-B and oncogene COX-2." View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3353542.

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22

Weinheimer, Eileen M. "The effect of acute resistance exercise on the expression of the COX-1 variants and COX-2 in human skeletal muscle : implicaitons [sic] for protein synthesis." Virtual Press, 2006. http://liblink.bsu.edu/uhtbin/catkey/1339598.

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Cyclooxygenase (COX) is the enzyme that catalyzes the rate-limiting step in prostaglandin (PG) synthesis. In skeletal muscle, PGF2a, has been shown to regulate protein synthesis, and ibuprofen and acetaminophen have been shown to block the normal increase in PGF2a and muscle protein synthesis following resistance exercise in humans. The purpose of this investigation was to determine the expression of the COX-1 (COX-1 variants: COX-1 v1, -1v2, -1 b,, -1 b2, and -1b3) and COX-2 isoforms following resistance exercise to help elucidate the isoform or variant through which PGF2a, ibuprofen, and ace

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23

Fritzsche, Julia [Verfasser], Lars-Christian [Akademischer Betreuer] Horn, and Christian [Gutachter] Wittekind. "Expression von EGFR, HER-2 und COX-2 beim Zervixkarzinom: Vergleich von Primärtumoren und Rezidiven / Julia Fritzsche ; Gutachter: Christian Wittekind ; Betreuer: Lars-Christian Horn." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/1238524877/34.

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24

Mattsson, Johanna. "An integrative strategy for targeted evaluation of biomarker expression in non-small cell lung cancer." Doctoral thesis, Uppsala universitet, Molekylär och morfologisk patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-285844.

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Despite improvements in therapy, the prognosis for non-small cell lung cancer (NSCLC) patients remains poor, and cure is only possible in localized tumors after surgical resection. A new generation of targeted cancer drugs has led to the expectation that lung cancer therapy can be significantly improved, but these drugs are today only an option in a small subset of NSCLC patients, and their effect is temporary. Therefore, the aim of this thesis was to characterize NSCLC in order to find new treatment targets and to evaluate biomarkers that further optimize therapy selection. In Paper I, the ex

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25

[Verfasser], Kanokwan Kaewmala. "Association and expression study of CD9, PLCz and COX-2 as candidate genes to improve boar sperm quality and fertility traits / Kanokwan Kaewmala." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1016156766/34.

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26

Ferguson, Shawn. "Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line." Thesis, University of Ottawa (Canada), 1999. http://hdl.handle.net/10393/8909.

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The cortical collecting duct (CCD) is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. By indirect immunofluorescence using isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both COX-1 and COX-2 were localized to the intercalated cells of the collecting duct on paraffin embedded mouse kidney sections. When COX enzyme activity was measured in the M-1 cells, both indomethacin (COX-1 and -2 inhibitor) and the specific COX-2 inhibitor NS-398 effectively blocked PGE2 synthesis. These

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27

Laube, Markus [Verfasser], Torsten Akademischer Betreuer] Kniess, Jens [Akademischer Betreuer] [Pietzsch, Jörg Akademischer Betreuer] Steinbach, and Thomas [Akademischer Betreuer] [Henle. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET / Markus Laube. Gutachter: Jörg Steinbach ; Thomas Henle. Betreuer: Torsten Kniess ; Jens Pietzsch ; Jörg Steinbach." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1069093106/34.

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28

Laube, Markus Verfasser], Torsten [Akademischer Betreuer] Kniess, Jens [Akademischer Betreuer] [Pietzsch, Jörg Akademischer Betreuer] Steinbach, and Thomas [Akademischer Betreuer] [Henle. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET / Markus Laube. Gutachter: Jörg Steinbach ; Thomas Henle. Betreuer: Torsten Kniess ; Jens Pietzsch ; Jörg Steinbach." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1069093106/34.

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29

Ferguson, Shawn. "Non-steriodal anti-inflammatory drug mediated regulation of COX-2 and EP¦3 receptor expression in the M-1 murine cortical collecting duct cell line." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0029/MQ67814.pdf.

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30

Vorsprach, Monique [Verfasser], Marino [Gutachter] Venerito, and Marek [Gutachter] Lommatzsch. "Expression von Cyclooxygenasen (COX-1 und COX-2) und Lipoxygenase (5-LOX) in Nasenpolypen und Bronchialschleimhaut bei Patienten mit Asthma bronchiale, rezidivierender Polyposis nasi und Analgetikainteroleranz : Korrelation mit klinischen und funktionellen Parametern / Monique Vorsprach ; Gutachter: Marino Venerito, Marek Lommatzsch." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2020. http://d-nb.info/1220035637/34.

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31

Cunha, Daniela Erica de Horta e. Goes Ribeiro da. "Avaliação da expressão de Cox-2 em tumores mamários da gata por imunohistoquímica : correlação com aspetos clinicopatológicos, classificação histopatológica e possíveis implicações clínicas." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2013. http://hdl.handle.net/10400.5/6098.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A cicloxigenase-2 (Cox-2) é uma enzima que desempenha um papel importante na tumorigénese e encontrando-se sobrexpressa em várias neoplasias humanas, incluindo o cancro da mama. Em medicina veterinária, alguns trabalhos mostram existir uma sobrexpressão da Cox-2 em certas neoplasias da espécie felina, incluindo nos tumores mamários, estando esta associada a pior prognóstico. Tendo em conta estas evidências, a utilização de fármacos anti-Cox-2 como agentes terapêuticos nas neoplasias mamárias é uma hipótese que poderá trazer ben

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32

Junior, Sérgio de Melo Alves. "\"Análise da expressão e mecanismos de ação da proteína COX-2 em cultura de células de carcinoma epidermóide bucal humano\"." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-13032007-085956/.

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Celecoxib é um antiinflamatório não esteroidal (AINE), inibidor seletivo da ciclooxigenase-2 (COX-2) usado em pesquisas recentes como agente anticarcinogênico. Os seus efeitos anti-neoplásicos dependem por um lado da sua capacidade de inibir a COX-2, mas por outro lado também age por mecanismos que independem da COX-2, em resumo o seu mecanismo de ação ainda não é completamente conhecido. O objetivo desta tese foi estudar os efeitos do celecoxib sobre as taxas de apoptose e os índices de proliferação celular de quatro linhagens celulares, Hn-6, Hn-19, Hn-30, Hn-31, de CECP e uma linhagem de qu

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33

Maia, Filho Hugo da Silva. "Expressão de aromatase no endométrio e seu papel no desenvolvimento de patologias uterinas." reponame:Repositório Institucional da UFBA, 2013. http://www.repositorio.ufba.br/ri/handle/ri/13092.

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p. 1-78<br>Submitted by Antonio Geraldo Couto Barreto (ppgms@ufba.br) on 2013-10-02T18:05:28Z No. of bitstreams: 1 Hugo Maia.pdf: 4715178 bytes, checksum: 067aa12a42b4bcfc56dd4ac8e4173ab8 (MD5)<br>Approved for entry into archive by Rodrigo Meirelles(rodrigomei@ufba.br) on 2013-10-02T22:07:53Z (GMT) No. of bitstreams: 1 Hugo Maia.pdf: 4715178 bytes, checksum: 067aa12a42b4bcfc56dd4ac8e4173ab8 (MD5)<br>Made available in DSpace on 2013-10-02T22:07:54Z (GMT). No. of bitstreams: 1 Hugo Maia.pdf: 4715178 bytes, checksum: 067aa12a42b4bcfc56dd4ac8e4173ab8 (MD5) Previous issue date: 2013<br>A exp

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Monteiro, Cíntia Júnia. "Análise da expressão de COX-2 em células H9c2 infectadas com T. cruzi cepa Berenice-62." reponame:Repositório Institucional da UFOP, 2013. http://www.repositorio.ufop.br/handle/123456789/4138.

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Programa de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa e Pós Graduação, Universidade Federal de Ouro Preto.<br>Submitted by Oliveira Flávia (flavia@sisbin.ufop.br) on 2014-12-09T18:58:02Z No. of bitstreams: 1 DISSERTAÇÃO_AnáliseExpressãoCOX-2.pdf: 1502334 bytes, checksum: d6e0f3cd743292f155280ff733f23955 (MD5)<br>Approved for entry into archive by Gracilene Carvalho (gracilene@sisbin.ufop.br) on 2014-12-09T21:07:52Z (GMT) No. of bitstreams: 1 DISSERTAÇÃO_AnáliseExpressãoCOX-2.pdf: 1502334 bytes, checksum: d6e0f3cd743292f155280ff7

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Kirkby, N. S., A. K. Zaiss, Paula Urquhart, et al. "LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression." 2013. http://hdl.handle.net/10454/7245.

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no<br>There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found that COX-1, not COX-2, is responsible for vascular prostacyclin production. Our experiments have relied on immunoassays to detect the prostacyclin breakdown product, 6-keto-PGF1α and antibodies to detect COX-2 protein. Whilst these are standard approaches, used by many laboratories, antibody-based techniques are inherently indirect and have

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Santos, Mariana Flórida. "COX-2 immunohistochemical expression conjunctival nevus and melanoma." Master's thesis, 2016. http://hdl.handle.net/10316/36692.

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Trabalho de revisão do 6º ano médico com vista à atribuição do grau de mestre (área científica de oftalmologia) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.<br>Introduction: Conjunctival melanomas are extremely rare tumours, representing only 2% of all malignant lesions of the eye. Both classification and correct diagnosis of ocular melanocytic lesions can be a challenge and ambiguity in diagnosis can result in severe misguidance of management and prognosis. Cyclooxygenase-2 is a prostaglandin synthase linked to tumour proliferation and metastization. COX-2 overexpression

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LIPARI, Luana. "Expression of metalloproteinases (MMP-2, MMP-9) and cycloxygenases (COX-1, COX-2) in salivary glands tumors." Doctoral thesis, 2011. http://hdl.handle.net/10447/105499.

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LIN, JUN-TING, and 林俊廷. "The effects of celecoxib on astroglial COX-2 expression." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/3fv7wa.

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碩士<br>慈濟大學<br>藥理暨毒理學碩士班/博士班<br>106<br>Astrocytes are the most abundant glial cell in the central nervous system (CNS) and play important physiological roles in the brain homeostasis. They can provide nutrition and growth factors to neuronal cells and remove extracellular glutamate. Remove of glutamate from extracellular space by astrocytic glutamate transporters can terminate its action and prevent receptors over stimulation-induced excitotoxicity in neuronal cells. In addition, astrocytes also play a critical role in pathological states-induced inflammation such as trauma or infection. Upon t

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Fritzsche, Julia. "Expression von EGFR, HER-2 und COX-2 beim Zervixkarzinom: Vergleich von Primärtumoren und Rezidiven." Doctoral thesis, 2012. https://ul.qucosa.de/id/qucosa%3A12022.

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Ziel dieser Studie war es, die Häufigkeit der Expression von EGFR, HER-2 sowie COX-2 im Zervixkarzinom zu eruieren. Dabei galt es herauszufinden, ob Unterschiede hinsichtlich des Nachweises dieser drei, möglicherweise therapeutisch relevanten Moleküle zwischen den primären, nicht vortherapierten und operierten Karzinomen und den multimodal vorbehandelten Rezidiven gab. In der vorliegenden retrospektiven Arbeit wurden 45 TMMR-operierte Primärtumoren und 28 LEER-operierte Rezidivtumoren der Universitätsfrauenklinik Leipzig (Triersches Institut) einbezogen und zusätzlich hinsichtlich der prognost

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Cheng, Chun-Ming, and 陳俊銘. "Homocysteine up-regulates COX-2 expression in Jurkat T lymphocytes." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/44495860190380884224.

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碩士<br>國立嘉義大學<br>生化科技學系研究所<br>99<br>The aims of this study are to investigate the molecular mechanisms of homocysteine-induce COX-2 expression of T lymphocyte. The effect of homocysteine on T lymphocyte cell line (Jurkat cell) COX-2 expression was examined in vitro. The result from this study may provide insight into the mechanisms contributing to inflammatory response in patients with hyperhomocysteinemia. Experimental results showed that homocysteine can induce T lymphocytes resulting from inflammation, but one of the major regulatory mechanisms is not clear . This study found that the T

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Chi, Hsin-I., and 紀欣怡. "The COX-2 expression of oral cancer and its precancerous lesions and the inhibition of propolis on COX-2." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/59503365216970145479.

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碩士<br>中山醫學大學<br>營養科學研究所<br>90<br>Oral cancer has been one of the ten major cancers in Taiwan. This study was to know the COX-2 expression in precancerous lesions tissue and to evaluated the inhibition of propolis on COX-2 expression. By Western blot assay, the COX-2 expression was great in the oral cancer tissue followed by leukoplakia and OSF. The levels of COX-2 expression also showed positive correlation with the severity of each lesions. Immunohistochemistry analysis showed that COX-2 expression in oral cancer tissue was very strong and much higher than in leukoplakia and OSF tissue. Furth

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Ping, Peng Jyh, and 彭治平. "Expression of cyclooxygenase-2(COX-2) in hypopharyngeal cancer and modulation of apoptosis and cell cycle progression by COX-2- specific inhibitors." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/37189137185833560059.

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碩士<br>長庚大學<br>臨床醫學研究所<br>91<br>Recent studies demonstrate that cyclooxygenase-2(COX-2) plays a crucial role in tumorigenesis of human cancers. Hypopharyngeal cancer is one of head and neck cancers with very poor prognosis in Taiwan. Betel nut chewing is the major contributory factor of hypopharyngeal cancer. The aim of this study was investigated the expression of COX-2 in primary tumor tissues of hypopharyngeal cancer and examined the effect of betel nut ingredient on COX-2 expression in normal hypopharyngeal and cancer cells. In addition, we addressed the effect of COX-2-specific inhibitor o

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Pei-TingWu and 吳沛庭. "EGF-induced COX-2 enhances ANGPTL4 expression and promotes HNSCC metastasis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/k8sq39.

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碩士<br>國立成功大學<br>藥理學研究所<br>103<br>Overexpression of EGFR is a common phenomenon in head and neck cancer squamous cancer cell (HNSCC). Activation of EGFR signaling pathway contributes to HNSCC metastasis and reduces patients’ survival. In our previous studies we found that EGF-induced angiopoietin-like 4 (ANGPTL4) was involved in tumor metastasis. However, the mechanisms of EGF-induced ANGPTL4 and the functional roles of ANGPTL4 in HNSCC metastasis remain unclear. In this study, we found that EGF activated ERK, but not NF-κB signaling pathway was involved in the regulation of ANGPTL4 expression.

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Shih, Wanyi, and 施宛宜. "Effects of Adlay Seed Extracts on COX-2 and iNOS Expression." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/58640217318387677057.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>89<br>According to the Chinese traditional therapy, adlay is used as an anti-inflammatory herb. In recent researches, adlay was also found that it has anti-tumor property in animal model. Chronic inflammation with a variety of epithelial malignancies has been recognized for centuries and it is thought that the key enzymes, COX-2 and iNOS, which are over- expressed during inflammation may be a general link between inflammation and cancer. In the present study, the effect of adlay extracts on COX-2 or iNOS expression was investigated in RAW264.7 cell and HT-29 cell. In

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Galuschka, Libusa. "Untersuchung der Expression von Cyclooxygenase-2, VEGF und der Gefäßdichte im Nierenzellkarzinom." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-AFBE-7.

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Kuo, Chi-Li, and 郭啟利. "Berberine Inhibits COX-2 Expression and Induces Apoptosis in Oral Cancer Cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/26080155993251749508.

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博士<br>國立陽明大學<br>藥理學研究所<br>92<br>Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX-2) plays a key role in prostaglandins (PGs) synthesis which is elevated in inflammation, this thesis examined whether the anti-inflammatory mechanism of berberine is mediated through COX-2 regulation. In oral cancer cell line OC2 and KB cells, a 12 hr berberine treatment (1, 10, and 100 μM) reduced prostaglandin E2 (PGE2) production dose-dependently with or without 12-O-tetradecanoylpho

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Yang, Wan-Yu, and 楊婉瑜. "CTGF inhibits cell motility and COX-2 expression in oral cancer cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/32336297242513709309.

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碩士<br>中國醫藥大學<br>醫學檢驗生物技術學系碩士班<br>99<br>Oral squamous cell carcinoma (SCC) has a striking tendency to migrate and metastasize. Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin synthase, has been implicated in tumor metastasis. Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells. However, the effect of CTGF on migration activity and COX-2 expression in human oral cells is mostly unknown. Here we found that CTGF reduced the migration and expression of COX-2 in human oral cancer cells.?n ?庮?

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Lai, Szu-Chai, and 賴思嘉. "Mechanisms of Endothelin-1-induced COX-2 Expression in Osteoblast MC3T3 cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/48214439014294292334.

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碩士<br>長庚大學<br>基礎醫學研究所<br>96<br>Abstract Mature bone homeostasis is maintained by bone remodeling cycle involved in osteoblast bone formation and osteoclast bone resorption. Under physiological conditions, the bone matrix is constantly renewed with bone remodeling to restructure itself in response to stimulation. Endothelin-1(ET-1), a potent vasoconstrictor, has been shown to be a pro-inflammatory cytokine like TNF- and IL-1β. ET-1 may cause a variety of inflammatory diseases, including airway inflammation, cutaneous inflammation, Crohn’s disease, ulcerative colitis, and liver cirrhosis. Under

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Chuang, Chun-Wei, and 莊峻偉. "Study of the molecular mechanism by which COX-2 regulates CCR7 expression." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/10298599344514498978.

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碩士<br>國立中山大學<br>生物醫學研究所<br>98<br>The metastatic spread of tumor cells is the major lethal aspect of cancer, and lymphatic metastasis is one of the most important routes. Recent studies indicated that cyclooxygenase-2 (COX-2) expression is frequently associated with lymph node metastasis and over-expression of COX-2 can enhance lymphatic invasion of cancer cells. The interaction of chemokines and their cognate receptors also plays a critical role in cancer metastasis. Previous results of our laboratory demonstrated that CCR7 is a downstream target for COX-2 and COX-2 up-regulated CCR7 expressio

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Chang, Cheng-Chi, and 張証棋. "Mechanisms of EV71-induced iNOS and COX-2 expression in rat brain astrocytes." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/48141919574903955869.

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碩士<br>長庚大學<br>天然藥物研究所<br>94<br>Enterovirus 71 (EV71), a neurotropic virus with undefined pathogenesis, has caused significant morbidity and mortality worldwide. The central nervous system (CNS) is the most vulnerable target of EV71 infection. Many reports have indicated that viral infection induced iNOS and COX-2 expression. Therefore, we used rat brain astrocyte cells (RBA cells) as a model to investigate p42/p44 MAPK, PDGFR, PI3K/Akt, PKC, NF-κB and AP-1 involved in EV71-induced iNOS and COX-2 expression using Western blotting, Reverse transcriptase-polymerase chain reaction (RT-PCR), and im

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