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1

Strzalkowski, Nicholas D. J., Ryan M. Peters, J. Timothy Inglis, and Leah R. Bent. "Cutaneous afferent innervation of the human foot sole: what can we learn from single-unit recordings?" Journal of Neurophysiology 120, no. 3 (2018): 1233–46. http://dx.doi.org/10.1152/jn.00848.2017.

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Анотація:
Cutaneous afferents convey exteroceptive information about the interaction of the body with the environment and proprioceptive information about body position and orientation. Four classes of low-threshold mechanoreceptor afferents innervate the foot sole and transmit feedback that facilitates the conscious and reflexive control of standing balance. Experimental manipulation of cutaneous feedback has been shown to alter the control of gait and standing balance. This has led to a growing interest in the design of intervention strategies that enhance cutaneous feedback and improve postural contr
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2

Abad, Alexander Co, David Reid, and Anuradha Ranasinghe. "A Novel Untethered Hand Wearable with Fine-Grained Cutaneous Haptic Feedback." Sensors 22, no. 5 (2022): 1924. http://dx.doi.org/10.3390/s22051924.

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During open surgery, a surgeon relies not only on the detailed view of the organ being operated upon and on being able to feel the fine details of this organ but also heavily relies on the combination of these two senses. In laparoscopic surgery, haptic feedback provides surgeons information on interaction forces between instrument and tissue. There have been many studies to mimic the haptic feedback in laparoscopic-related telerobotics studies to date. However, cutaneous feedback is mostly restricted or limited in haptic feedback-based minimally invasive studies. We argue that fine-grained in
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3

Toth, Aidan L., Keith K. Fenrich, Kelvin E. Jones, and John E. Misiaszek. "Coupling of single cutaneous afferents in the hand with ankle muscles, and their response to rapid light touch displacements." Journal of Neurophysiology 127, no. 4 (2022): 1040–53. http://dx.doi.org/10.1152/jn.00280.2021.

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Light touch provides cutaneous feedback argued to contribute to balance control and shown to reduce postural sway. We demonstrate that activity of cutaneous afferents in the median nerve modulates motor pool excitability of ankle muscles at short latencies and that these afferents respond when a light touch contact is displaced. These findings suggest that cutaneous receptors of the hand can contribute to rapid regulation of muscle activity important to standing balance.
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4

Zehr, E. Paul, Marc Klimstra, Katie Dragert, et al. "Enhancement of Arm and Leg Locomotor Coupling With Augmented Cutaneous Feedback From the Hand." Journal of Neurophysiology 98, no. 3 (2007): 1810–14. http://dx.doi.org/10.1152/jn.00562.2007.

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Cutaneous feedback from the hand could assist with coordination between the arms and legs during locomotion. Previously we used a reduced walking model of combined arm and leg (arm&leg) cycling to examine the separate effects of rhythmic arm (arm) and leg (leg) movement. Here we use this same paradigm to test the modulation H-reflexes with and without interlimb cutaneous conditioning evoked by stimulating a nerve innervating the hand (superficial radial, SR). It was hypothesized that both arm and leg would contribute significantly to suppression of H-reflex amplitude during arm&leg. We
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5

Bolton, D. A. E., and J. E. Misiaszek. "Contribution of Hindpaw Cutaneous Inputs to the Control of Lateral Stability During Walking in the Cat." Journal of Neurophysiology 102, no. 3 (2009): 1711–24. http://dx.doi.org/10.1152/jn.00445.2009.

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To delineate the role of cutaneous feedback from the paws in the regulation of balance during walking, we compared the corrective responses of cats to lateral support surface translation before and after cutaneous denervation of the hindpaws. In addition, we compared characteristics of undisturbed walking before and after denervation. Electromyographic and kinematic data were collected from three cats trained to walk across a walkway, the central portion of which could be unexpectedly translated laterally in either direction. Following denervation, all of the cats changed their step width, low
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6

Pearcey, Gregory E. P., and E. Paul Zehr. "We Are Upright-Walking Cats: Human Limbs as Sensory Antennae During Locomotion." Physiology 34, no. 5 (2019): 354–64. http://dx.doi.org/10.1152/physiol.00008.2019.

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Анотація:
Humans and cats share many characteristics pertaining to the neural control of locomotion, which has enabled the comprehensive study of cutaneous feedback during locomotion. Feedback from discrete skin regions on both surfaces of the human foot has revealed that neuromechanical responses are highly topographically organized and contribute to “sensory guidance” of our limbs during locomotion.
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7

Prattichizzo, D., C. Pacchierotti, and G. Rosati. "Cutaneous Force Feedback as a Sensory Subtraction Technique in Haptics." IEEE Transactions on Haptics 5, no. 4 (2012): 289–300. http://dx.doi.org/10.1109/toh.2012.15.

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8

Pacchierotti, Claudio, Asad Tirmizi, Gianni Bianchini, and Domenico Prattichizzo. "Enhancing the Performance of Passive Teleoperation Systems via Cutaneous Feedback." IEEE Transactions on Haptics 8, no. 4 (2015): 397–409. http://dx.doi.org/10.1109/toh.2015.2457927.

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9

Mildren, Robyn L., Catherine M. Hare, and Leah R. Bent. "Cutaneous afferent feedback from the posterior ankle contributes to proprioception." Neuroscience Letters 636 (January 2017): 145–50. http://dx.doi.org/10.1016/j.neulet.2016.10.058.

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10

Gandevia, S. C., and David Burke. "Does the nervous system depend on kinesthetic information to control natural limb movements?" Behavioral and Brain Sciences 15, no. 4 (1992): 614–32. http://dx.doi.org/10.1017/s0140525x0007254x.

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Abstract This target article draws together two groups of experimental studies on the control of human movement through peripheral feedback and centrally generated signals of motor commands. First, during natural movement, feedback from muscle, joint, and cutaneous afferents changes; in human subjects these changes have reflex and kinesthetic consequences. Recent psychophysical and microneurographic evidence suggests that joint and even cutaneous afferents may have a proprioceptive role. Second, the role of centrally generated motor commands in the control of normal movements and movements fol
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11

Pacchierotti, C., L. Meli, F. Chinello, M. Malvezzi, and D. Prattichizzo. "Cutaneous haptic feedback to ensure the stability of robotic teleoperation systems." International Journal of Robotics Research 34, no. 14 (2015): 1773–87. http://dx.doi.org/10.1177/0278364915603135.

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12

Pacchierotti, Claudio, Asad Tirmizi, and Domenico Prattichizzo. "Improving Transparency in Teleoperation by Means of Cutaneous Tactile Force Feedback." ACM Transactions on Applied Perception 11, no. 1 (2014): 1–16. http://dx.doi.org/10.1145/2604969.

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13

Hurteau, Marie-France, Yann Thibaudier, Charline Dambreville, Corinne Desaulniers, and Alain Frigon. "Effect of stimulating the lumbar skin caudal to a complete spinal cord injury on hindlimb locomotion." Journal of Neurophysiology 113, no. 2 (2015): 669–76. http://dx.doi.org/10.1152/jn.00739.2014.

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Sensory feedback is a potent modulator of the locomotor pattern generated by spinal networks. The purpose of this study was to assess the effect of cutaneous inputs from the back on the spinal-generated locomotor pattern. The spinal cord of six adult cats was transected at low thoracic levels. Cats were then trained to recover hindlimb locomotion. During experiments, the skin overlying lumbar vertebrae L2 to L7 was mechanically stimulated by a small calibrated clip or by manual pinching. Trials without and with cutaneous stimulation were performed at a treadmill speed of 0.4 m/s. Although manu
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14

Lee, Soung-Hoon, Mi-Yeon Kim, Hyun-Yi Kim, et al. "The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing." Journal of Experimental Medicine 212, no. 7 (2015): 1061–80. http://dx.doi.org/10.1084/jem.20141601.

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Анотація:
Wnt/β-catenin signaling plays important roles in cutaneous wound healing and dermal fibrosis. However, its regulatory mechanism has not been fully elucidated, and a commercially available wound-healing agent targeting this pathway is desirable but currently unavailable. We found that CXXC-type zinc finger protein 5 (CXXC5) serves as a negative feedback regulator of the Wnt/β-catenin pathway by interacting with the Dishevelled (Dvl) protein. In humans, CXXC5 protein levels were reduced in epidermal keratinocytes and dermal fibroblasts of acute wounds. A differential regulation of β-catenin, α-s
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15

Aris, Mariana, María Marcela Barrio, and José Mordoh. "Lessons from Cancer Immunoediting in Cutaneous Melanoma." Clinical and Developmental Immunology 2012 (2012): 1–14. http://dx.doi.org/10.1155/2012/192719.

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Анотація:
We will revisit the dual role of the immune system in controlling and enabling tumor progression, known ascancer immunoediting. We will go through the different phases of this phenomenon, exposing the most relevant evidences obtained from experimental models and human clinical data, with special focus on Cutaneous Melanoma, an immunogenic tumorper excellence. We will describe the different immunotherapeutic strategies employed and consider current models accounting for tumor heterogeneity. And finally, we will propose a rational discussion of the progress made and the future challenges in the
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16

Pacchierotti, Claudio, Domenico Prattichizzo, and Katherine J. Kuchenbecker. "Cutaneous Feedback of Fingertip Deformation and Vibration for Palpation in Robotic Surgery." IEEE Transactions on Biomedical Engineering 63, no. 2 (2016): 278–87. http://dx.doi.org/10.1109/tbme.2015.2455932.

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17

See, Aaron Raymond, Thad Jacob Tiong, Lanz Benedict De Guzman, Kenneth Contee, Garfield Greg Lim, and Carl Sebastian Yebes. "Development of Localized Cutaneous Force Feedback System for Robotics Assisted Surgery Systems." Procedia Computer Science 246 (2024): 1160–69. http://dx.doi.org/10.1016/j.procs.2024.09.540.

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18

Park, Jaeyoung, Yonghwan Oh, and Hong Z. Tan. "Effect of Cutaneous Feedback on the Perceived Hardness of a Virtual Object." IEEE Transactions on Haptics 11, no. 4 (2018): 518–30. http://dx.doi.org/10.1109/toh.2018.2854721.

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19

Cruz-Montecinos, Carlos, Huub Maas, Carla Pellegrin-Friedmann, and Claudio Tapia. "The importance of cutaneous feedback on neural activation during maximal voluntary contraction." European Journal of Applied Physiology 117, no. 12 (2017): 2469–77. http://dx.doi.org/10.1007/s00421-017-3734-6.

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20

Kim, Yushin, Jae Kun Shim, Young-Ki Hong, Sang-Heon Lee, and Bum Chul Yoon. "Cutaneous sensory feedback plays a critical role in agonist–antagonist co-activation." Experimental Brain Research 229, no. 2 (2013): 149–56. http://dx.doi.org/10.1007/s00221-013-3601-6.

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21

Robinson, Deborah J., Ankit Patel, Karin J. Purdie, et al. "Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma." Journal of Investigative Dermatology 139, no. 8 (2019): 1658–71. http://dx.doi.org/10.1016/j.jid.2019.01.020.

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22

Frisoli, A., M. Solazzi, F. Salsedo, and M. Bergamasco. "A Fingertip Haptic Display for Improving Curvature Discrimination." Presence: Teleoperators and Virtual Environments 17, no. 6 (2008): 550–61. http://dx.doi.org/10.1162/pres.17.6.550.

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Анотація:
This paper presents a novel haptic device providing both kinesthetic and cutaneous cues informative of shape geometry at the contact point. The system is composed of a supporting kinesthetic haptic interface and an innovative fingertip haptic display that can instantaneously orient a small plate along the tangent plane at the contact point with a virtual shape and bring it in contact with the fingertip. We show how this local augmentation of displayed haptic information can improve human performance in shape exploration, by assessing perception thresholds in curvature discrimination. When kine
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23

Perrier, Jean-François, Boris Lamotte D'Incamps, Nezha Kouchtir-Devanne, Léna Jami, and Daniel Zytnicki. "Cooperation of Muscle and Cutaneous Afferents in the Feedback of Contraction to Peroneal Motoneurons." Journal of Neurophysiology 83, no. 6 (2000): 3201–8. http://dx.doi.org/10.1152/jn.2000.83.6.3201.

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Peroneal motoneurons were recorded intracellularly in anesthetized cats during sustained submaximal contractions of peroneus brevis muscle (PB) elicited by repetitive electrical stimulation of motor axons in the distal portion of cut ventral root filaments. Mechanical stimulation of the territory innervated by the superficial peroneal nerve (SP) was applied during contraction to assess the influence of afferents from this territory on the contraction-induced excitation of motoneurons. In 21 peroneal motoneurons in which PB contraction evoked excitatory potentials, a stimulation engaging mechan
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24

Lee, Seoyoung, Yeonjoo Yoo, Heeyoung Moon, In-Seon Lee, and Younbyoung Chae. "Enhanced Empathic Pain by Facial Feedback." Brain Sciences 14, no. 1 (2023): 5. http://dx.doi.org/10.3390/brainsci14010005.

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The facial feedback hypothesis states that feedback from cutaneous and muscular afferents affects our emotion. Based on the facial feedback hypothesis, the purpose of this study was to determine whether enhancing negative emotion by activating a facial muscle (corrugator supercilii) increases the intensity of cognitive and emotional components of empathic pain. We also assessed whether the muscle contraction changed the pupil size, which would indicate a higher level of arousal. Forty-eight individuals completed 40 muscular contraction and relaxation trials while looking at images of five male
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25

Muir, G. D., and J. D. Steeves. "Phasic cutaneous input facilitates locomotor recovery after incomplete spinal injury in the chick." Journal of Neurophysiology 74, no. 1 (1995): 358–68. http://dx.doi.org/10.1152/jn.1995.74.1.358.

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1. Walking and swimming of hatchling chicks was videotaped before hemisection of the left thoracic cord and thereafter at regular intervals, for up to 2 wk. With the use of kinematic techniques, movements of the left knee and ankle were quantified to assess recovery of the ipsilateral leg during walking and swimming trials. To study the effects of exteroceptive (cutaneous) feedback in the absence of limb loading, one group of animals was also provided with cutaneous stimulation during swimming in the form of neutrally buoyant tubes that only contacted the foot during the retraction (extension)
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26

Tripathy, Satyaswarup, Devi Prasad Mohapatra, Friji Meethale Thiruvoth, Ramesh Kumar Sharma, Likhitha Reddy, and Neljo Thomas. "An Innovative Skin Simulation Model to Augment Competency-based Training in Facial Plastic Surgery." Indian Journal of Plastic Surgery 55, no. 01 (2022): 102–6. http://dx.doi.org/10.1055/s-0041-1740083.

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Abstract Introduction Competency-based medical education (CBME) approach in the medical curriculum has been introduced globally with the goal of providing flexibility, accountability, and learner-centeredness among medical learners. Traditional surgical skill training in most places has relied on “see one, do one, teach one model,” while simulation model-based training has been shown to improve competencies in surgical trainees. We wanted to assess the usefulness of a hydrophilic barrier adhesive foam wound dressing as a novel skin simulation model for learning biomechanics and practice of cut
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27

TAKAMUKU, Shinya, Shunsuke SEKIMOTO, Naoya YAMANO, and Koh HOSODA. "2A1-G10 Behavior Discovery by a Musculoskeletal Arm with Cutaneous and Muscular Feedback." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2009 (2009): _2A1—G10_1—_2A1—G10_2. http://dx.doi.org/10.1299/jsmermd.2009._2a1-g10_1.

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28

CHIBA, Hironori, Takeshi KANO, Takuya UMEDACHI, and Akio ISHIGURO. "2A2-S03 Decentralized Control of 1D Crawling Locomotion That Exploits Cutaneous Sensory Feedback." Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2015 (2015): _2A2—S03_1—_2A2—S03_4. http://dx.doi.org/10.1299/jsmermd.2015._2a2-s03_1.

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29

Moon, Jeongin, Prabhat Pathak, Sudeok Kim, et al. "Supra-threshold vibration applied to the foot soles enhances jump height under maximum effort." PLOS ONE 17, no. 4 (2022): e0266597. http://dx.doi.org/10.1371/journal.pone.0266597.

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Previous studies have shown that absence or reduction of cutaneous sensory feedback can diminish human motor performance under maximum effort. However, it has not been explored whether any appropriate intervention in the cutaneous sensory input can augment the output motor performance, particularly in motor tasks such as jumping that involve the kinematic chain of the entire body. Using shoes with active vibrating insoles, we applied mechanical vibration to the soles of 20 young and healthy adults and evaluated the change in the jump height and muscle activation using within-participants repea
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30

Xu, Chang, Yuxiang Wang, and Gregory J. Gerling. "An elasticity-curvature illusion decouples cutaneous and proprioceptive cues in active exploration of soft objects." PLOS Computational Biology 17, no. 3 (2021): e1008848. http://dx.doi.org/10.1371/journal.pcbi.1008848.

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Our sense of touch helps us encounter the richness of our natural world. Across a myriad of contexts and repetitions, we have learned to deploy certain exploratory movements in order to elicit perceptual cues that are salient and efficient. The task of identifying optimal exploration strategies and somatosensory cues that underlie our softness perception remains relevant and incomplete. Leveraging psychophysical evaluations combined with computational finite element modeling of skin contact mechanics, we investigate an illusion phenomenon in exploring softness; where small-compliant and large-
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31

Ruff, Casey R., Andreas B. Miller, Mona L. Delva, Kim Lajoie, and Daniel S. Marigold. "Modification of cutaneous reflexes during visually guided walking." Journal of Neurophysiology 111, no. 2 (2014): 379–93. http://dx.doi.org/10.1152/jn.01076.2012.

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Although it has become apparent that cutaneous reflexes can be adjusted based on the phase and context of the locomotor task, it is not clear to what extent these reflexes are regulated when locomotion is modified under visual guidance. To address this, we compared the amplitude of cutaneous reflexes while subjects performed walking tasks that required precise foot placement. In one experiment, subjects walked overground and across a horizontal ladder with narrow raised rungs. In another experiment, subjects walked and stepped onto a series of flat targets, which required different levels of p
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32

Augurelle, Anne-Sophie, Allan M. Smith, Thierry Lejeune, and Jean-Louis Thonnard. "Importance of Cutaneous Feedback in Maintaining a Secure Grip During Manipulation of Hand-Held Objects." Journal of Neurophysiology 89, no. 2 (2003): 665–71. http://dx.doi.org/10.1152/jn.00249.2002.

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Previous research has shown that grip and load forces are modulated simultaneously during manipulation of a hand-held object. This close temporal coupling suggested that both forces are controlled by an internal model within the CNS that predicts the changes in tangential force on the fingers. The objective of the present study was to examine how the internal model would compensate for the loss of cutaneous sensation through local anesthesia of the index and thumb. Ten healthy adult subjects (5 men and 5 women aged 20–57 yr) were asked to grasp, lift, and hold stationary, a 250 g object for 20
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33

Sekine, Tomohito, Yi-Fei Wang, Jinseo Hong, et al. "Artificial Cutaneous Sensing of Object Slippage using Soft Robotics with Closed‐Loop Feedback Process." Small Science 1, no. 3 (2021): 2100002. http://dx.doi.org/10.1002/smsc.202100002.

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34

Sekine, Tomohito, Yi-Fei Wang, Jinseo Hong, et al. "Artificial Cutaneous Sensing of Object Slippage using Soft Robotics with Closed‐Loop Feedback Process." Small Science 1, no. 3 (2021): 2170007. http://dx.doi.org/10.1002/smsc.202170007.

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35

Atkins, Reginald M., Timothy J. Fawcett, Richard Gilbert, et al. "Real-time impedance feedback to enhance cutaneous gene electrotransfer in a murine skin model." Bioelectrochemistry 142 (December 2021): 107885. http://dx.doi.org/10.1016/j.bioelechem.2021.107885.

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36

Prattichizzo, Domenico, Francesco Chinello, Claudio Pacchierotti, and Monica Malvezzi. "Towards Wearability in Fingertip Haptics: A 3-DoF Wearable Device for Cutaneous Force Feedback." IEEE Transactions on Haptics 6, no. 4 (2013): 506–16. http://dx.doi.org/10.1109/toh.2013.53.

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37

Löscher, W. N., E. Gallasch, A. G. Cresswell, A. Thorstensson, and G. Ladurner. "M92 Task-dependent significance of cutaneous afferent feedback for the accuracy of force matching." Electroencephalography and Clinical Neurophysiology 99, no. 4 (1996): 391. http://dx.doi.org/10.1016/0013-4694(96)88676-7.

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38

Mori, Kazuo, and Hideko Mori. "Another Test of the Passive Facial Feedback Hypothesis: When Your Face Smiles, You Feel Happy." Perceptual and Motor Skills 109, no. 1 (2009): 76–78. http://dx.doi.org/10.2466/pms.109.1.76-78.

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Анотація:
88 undergraduates (44 men, 44 women) participated in an experiment to examine whether the cutaneous sensation of having the cheeks lifted would cause a feeling of happiness. Two types of paired adhesive bandages connected with rubber bands were prepared and used either to raise or lower the cheeks. While the bandages were applied, the participants rated their feelings. The results showed that 50 participants felt happiness when their cheeks were lifted, statistically significant compared to the 27 who felt sadness. They confirmed the hypothesis that people may feel happy when their cheeks are
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39

Macefield, Vaughan G., Lucy Norcliffe-Kaufmann, Niamh Goulding, Jose-Alberto Palma, Cristina Fuente Mora, and Horacio Kaufmann. "Increasing cutaneous afferent feedback improves proprioceptive accuracy at the knee in patients with sensory ataxia." Journal of Neurophysiology 115, no. 2 (2016): 711–16. http://dx.doi.org/10.1152/jn.00148.2015.

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Анотація:
Hereditary sensory and autonomic neuropathy type III (HSAN III) features disturbed proprioception and a marked ataxic gait. We recently showed that joint angle matching error at the knee is positively correlated with the degree of ataxia. Using intraneural microelectrodes, we also documented that these patients lack functional muscle spindle afferents but have preserved large-diameter cutaneous afferents, suggesting that patients with better proprioception may be relying more on proprioceptive cues provided by tactile afferents. We tested the hypothesis that enhancing cutaneous sensory feedbac
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40

Johnson, Blair Z., Andrew W. Stevenson, Cecilia M. Prêle, Mark W. Fear, and Fiona M. Wood. "The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing." Biomedicines 8, no. 5 (2020): 101. http://dx.doi.org/10.3390/biomedicines8050101.

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The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β
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41

Traverse, Elodie, Clémentine Brun, Émilie Harnois, and Catherine Mercier. "Impact of Experimental Tonic Pain on Corrective Motor Responses to Mechanical Perturbations." Neural Plasticity 2020 (July 31, 2020): 1–13. http://dx.doi.org/10.1155/2020/8864407.

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Анотація:
Movement is altered by pain, but the underlying mechanisms remain unclear. Assessing corrective muscle responses following mechanical perturbations can help clarify these underlying mechanisms, as these responses involve spinal (short-latency response, 20-50 ms), transcortical (long-latency response, 50-100 ms), and cortical (early voluntary response, 100-150 ms) mechanisms. Pairing mechanical (proprioceptive) perturbations with different conditions of visual feedback can also offer insight into how pain impacts on sensorimotor integration. The general aim of this study was to examine the impa
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42

Barss, Trevor S., Gregory E. P. Pearcey, Bridget Munro, Jennifer L. Bishop, and E. Paul Zehr. "Effects of a compression garment on sensory feedback transmission in the human upper limb." Journal of Neurophysiology 120, no. 1 (2018): 186–95. http://dx.doi.org/10.1152/jn.00581.2017.

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Анотація:
Compression apparel is popular in both medical and sport performance settings. Perceived benefits are suggested to include changes in sensory feedback transmission caused by activation of mechanoreceptors. However, little is known about effects of compression apparel on sensorimotor control. Our purpose was to mechanistically examine whether compression apparel modulates sensory feedback transmission and reaching accuracy in the upper limb. Two experiments were completed under CONTROL and COMPRESSION (sleeve applied across the elbow joint) conditions. M-waves and H-reflexes were elicited by st
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43

Aguilar, Juan, Casto Rivadulla, Cristina Soto, and Antonio Canedo. "New Corticocuneate Cellular Mechanisms Underlying the Modulation of Cutaneous Ascending Transmission in Anesthetized Cats." Journal of Neurophysiology 89, no. 6 (2003): 3328–39. http://dx.doi.org/10.1152/jn.01085.2002.

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Анотація:
The ascending cutaneous transmission through the middle cuneate nucleus is subject to cortico-feedback modulation. This work studied the intracuneate cellular mechanisms underlying the corticocuneate influence. Single unit extracellular records combined with iontophoresis showed that the corticocuneate input activates cuneo-lemniscal (CL) and noncuneo-lemniscal (nCL) cells via N-methyl-d-aspartate (NMDA) and non-NMDA receptors as shown by the decrease of the cortical-induced activation on ejection of CNQX and APV, either alone or in combination. These results were confirmed by in vivo intracel
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44

Haftel, Valerie K., Jonathan F. Prather, C. J. Heckman, and Timothy C. Cope. "Recruitment of Cat Motoneurons in the Absence of Homonymous Afferent Feedback." Journal of Neurophysiology 86, no. 2 (2001): 616–28. http://dx.doi.org/10.1152/jn.2001.86.2.616.

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This study provides the first test in vivo of the hypothesis that group Ia muscle-stretch afferents aid in preventing reversals in the orderly recruitment of motoneurons. This hypothesis was tested by studying recruitment of motoneurons deprived of homonymous afferent input. Recruitment order was measured in decerebrate, paralyzed cats from dual intra-axonal records obtained simultaneously from pairs of medial gastrocnemius (MG) motoneurons. Pairs of MG motor axons were recruited in eight separate trials of the reflex discharge evoked by stimulation of the caudal cutaneous sural (CCS) nerve. S
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45

Yoon, Minguen, Eunhwan Kim, Seol Hwa Seo, Geon-Uk Kim та Kang-Yell Choi. "KY19382 Accelerates Cutaneous Wound Healing via Activation of the Wnt/β-Catenin Signaling Pathway". International Journal of Molecular Sciences 24, № 14 (2023): 11742. http://dx.doi.org/10.3390/ijms241411742.

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Анотація:
The Wnt/β-catenin signaling pathway plays important roles in the multi-phases of wound healing: homeostasis, inflammation, proliferative, and remodeling phases. However, there are no clinically available therapeutic agents targeting the Wnt/β-catenin pathway. In this study, we tested the effect of 5, 6-dichloroindirubin-3′-methoxime (KY19382), a small molecule that activates the Wnt/β-catenin pathway via interference with the function of the negative feedback regulator CXXC5, on cutaneous wound healing. KY19382 significantly enhanced cell migration of human keratinocytes and dermal fibroblasts
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46

Bloomfield, Aaron, and Norman I. Badler. "Virtual Training via Vibrotactile Arrays." Presence: Teleoperators and Virtual Environments 17, no. 2 (2008): 103–20. http://dx.doi.org/10.1162/pres.17.2.103.

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Анотація:
What is often missing from many virtual worlds and training simulations is a physical sense of the confinement and constraint of the virtual environment. We present a method for providing localized cutaneous vibratory feedback to the user's right arm. We created a sleeve of tactors linked to a real-time human model; the tactors activate to apply sensation to the corresponding body area. The hypothesis is that vibrotactile feedback to body areas provides the wearer sufficient guidance to assume correct body configurations and ascertain the existence and physical realism of access paths. We pres
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47

Pearcey, Gregory E. P., Yao Sun, and E. Paul Zehr. "Plantarflexion force is amplified with sensory stimulation during ramping submaximal isometric contractions." Journal of Neurophysiology 123, no. 4 (2020): 1427–38. http://dx.doi.org/10.1152/jn.00650.2019.

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Анотація:
Stimulating cutaneous nerves, causing tactile sensations, reduces the perceived heaviness of an object, suggesting that either descending commands are facilitated or the perception of effort is reduced when tactile sensation is enhanced. Sensory stimulation can also mitigate decrements in motor output and spinal cord excitability that occur with fatigue. The effects of sensory stimulation applied with coincident timing of voluntary force output, however, are yet to be examined. Therefore, the purpose of this study was to examine effects of sensory enhancement to nerves innervating opposed skin
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48

Strzalkowski, Nicholas D. J., Catherine R. Lowrey, Stephen D. Perry, David R. Williams, Scott J. Wood, and Leah R. Bent. "Selective weighting of cutaneous receptor feedback and associated balance impairments following short duration space flight." Neuroscience Letters 592 (April 2015): 94–98. http://dx.doi.org/10.1016/j.neulet.2015.02.046.

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49

Sun, Yao, Gregory E. P. Pearcey, and E. Paul Zehr. "Enhanced somatosensory feedback modulates cutaneous reflexes in arm muscles during self-triggered or prolonged stimulation." Experimental Brain Research 238, no. 2 (2020): 295–304. http://dx.doi.org/10.1007/s00221-019-05678-w.

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50

Rabin, Ely, Simone B. Bortolami, Paul DiZio, and James R. Lackner. "Haptic Stabilization of Posture: Changes in Arm Proprioception and Cutaneous Feedback for Different Arm Orientations." Journal of Neurophysiology 82, no. 6 (1999): 3541–49. http://dx.doi.org/10.1152/jn.1999.82.6.3541.

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Анотація:
Postural sway during quiet stance is attenuated by actively maintained contact of the index finger with a stationary surface, even if the level of applied force (<1 N) cannot provide mechanical stabilization. In this situation, changes in force level at the fingertip lead changes in center of foot pressure by ∼250 ms. These and related findings indicate that stimulation of the fingertip combined with proprioceptive information about the hand and arm can serve as an active sensor of body position relative to the point of contact. A geometric analysis of the relationship between hand and tors
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