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Статті в журналах з теми "Cytokines"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Trinchieri, Giorgio. "Cytokines and cytokine receptors." Immunological Reviews 202, no. 1 (2004): 5–7. http://dx.doi.org/10.1111/j.0105-2896.2004.00217.x.

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2

Dayer, J. M. "Cytokines and cytokine antagonists." Fresenius' Journal of Analytical Chemistry 343, no. 1 (1992): 33–34. http://dx.doi.org/10.1007/bf00331973.

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3

Berti, E., and R. Caputo. "Cytokines, cytokine receptors and cytokine antibodies." Melanoma Research 6, SUPPLEMENT 1 (1996): S25. http://dx.doi.org/10.1097/00008390-199609001-00064.

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4

van Deventer, S. J. H. "Cytokines and cytokine-based therapies." Current Opinion in Gastroenterology 14, no. 4 (1998): 317–21. http://dx.doi.org/10.1097/00001574-199807000-00008.

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5

Li, Aileen W., and Wendell A. Lim. "Engineering cytokines and cytokine circuits." Science 370, no. 6520 (2020): 1034–35. http://dx.doi.org/10.1126/science.abb5607.

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6

Burger, D., and J. M. Dayer. "Inhibitory cytokines and cytokine inhibitors." Neurology 45, Issue 6, Supplement 6 (1995): S39—S43. http://dx.doi.org/10.1212/wnl.45.6_suppl_6.s39.

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7

Ansel, John, Patricia Perry, Jeffrey Brown, et al. "Cytokine Modulation of Keratinocyte Cytokines." Journal of Investigative Dermatology 94, no. 6 (1990): s101—s107. http://dx.doi.org/10.1111/1523-1747.ep12876053.

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8

Thipphawong, John. "Inhaled cytokines and cytokine antagonists." Advanced Drug Delivery Reviews 58, no. 9-10 (2006): 1089–105. http://dx.doi.org/10.1016/j.addr.2006.07.014.

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9

Ramani, Thulasi, Carol S. Auletta, Daniel Weinstock, et al. "Cytokines." International Journal of Toxicology 34, no. 4 (2015): 355–65. http://dx.doi.org/10.1177/1091581815584918.

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Анотація:

Over the past 30 years, the world of pharmaceutical toxicology has seen an explosion in the area of cytokines. An overview of the many aspects of cytokine safety evaluation currently in progress and evolving strategies for evaluating these important entities was presented at this symposium. Cytokines play a broad role to help the immune system respond to diseases, and drugs which modulate their effect have led to some amazing therapies. Cytokines may be “good” when stimulating the immune system to fight a foreign pathogen or attack tumors. Other “good” cytokine effects include reduction of an

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10

Standiford, Theodore. "Anti-inflammatory Cytokines and Cytokine Antagonists." Current Pharmaceutical Design 6, no. 6 (2000): 633–49. http://dx.doi.org/10.2174/1381612003400533.

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11

BARRY, M., and G. McFADDEN. "Virus encoded cytokines and cytokine receptors." Parasitology 115, no. 7 (1997): 89–100. http://dx.doi.org/10.1017/s0031182097001820.

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In order to replicate efficiently within the host, viruses have evolved multiple strategies to evade the host's immune system. In many cases viruses have actually hijacked various components of the host's immune system to ensure their own survival. One such strategy is the expression of virus encoded cytokines and cytokine receptors. Members of the poxvirus and herpesvirus families have been particularly successful with this strategy. The study of virus survival strategies provides important information regarding both virus biology as well as information about the immune system itself.

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12

Olbei, M., D. Modos, D. Cozzetto, N. Powell, and T. Korcsmaros. "P070 Global cytokine—cytokine interaction framework to uncover communication channels between elements of the immune system." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i236. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0200.

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Abstract Background Cytokines are small peptides that signal between a variety of cell types and are one of the fundamental communication elements of the immune system. A variety of cytokine—cytokine interactions have previously been investigated in the literature, describing cytokines activating or inhibiting other cytokines in target cell types, and thus progressing the immune response to infection and illness. Disruption of cytokine communication is often an important goal in drug development as these compounds allow quelling and managing an overactive immune response in chronic diseases, s

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13

Łabędź, Wojciech, Anna Przybyla, Agnieszka Zimna, Mikołaj Dąbrowski, and Łukasz Kubaszewski. "The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review." International Journal of Molecular Sciences 24, no. 4 (2023): 3785. http://dx.doi.org/10.3390/ijms24043785.

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Although many studies have investigated the role of cytokines in bone metastases, our knowledge of their function in spine metastasis is limited. Therefore, we performed a systematic review to map the available evidence on the involvement of cytokines in spine metastasis in solid tumors. A PubMed search identified 211 articles demonstrating a functional link between cytokines/cytokine receptors and bone metastases, including six articles confirming the role of cytokines/cytokine receptors in spine metastases. A total of 68 cytokines/cytokine receptors were identified to mediate bone metastases

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14

Lin, Jian-Xin, and Warren J. Leonard. "Fine-Tuning Cytokine Signals." Annual Review of Immunology 37, no. 1 (2019): 295–324. http://dx.doi.org/10.1146/annurev-immunol-042718-041447.

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Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or paracrine actions, with most cytokines acting in the immune and/or hematopoietic system. They are typically pleiotropic, controlling development, cell growth, survival, and/or differentiation. Correspondingly, cytokines are clinically important, and augmenting or attenuating cytokine signals can have deleterious or therapeutic effects. Besides physiological fine-tuning of cytokine signals, altering the nature or potency of the signal can be important in pathophysiological responses and can also provide

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15

Buxton, Miatta A., Noemi Meraz-Cruz, Brisa N. Sánchez, et al. "Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding “Normal” Inflammation to Inform Future Screening." American Journal of Perinatology 37, no. 06 (2019): 613–20. http://dx.doi.org/10.1055/s-0039-1685491.

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Abstract Objective This study aimed to describe characteristics of cervicovaginal cytokines obtained during pregnancy from women who subsequently delivered at term. Study Design We used repeated measures of 20 cervicovaginal cytokines, collected on average on a monthly basis, from the second to the ninth month of gestation among 181 term pregnancies in the Mexico City Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses cohort (2009–2014). Cytokines were quantified using multiplex assay. Results Cytokine distributions differed more between than within cyto

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16

Yuwen, Li, Yang Ciqiu, Shi Yi, et al. "A Pilot Study of Protein Microarray for Simultaneous Analysis of 274 Cytokines Between Abdominal Aortic Aneurysm and Normal Aorta." Angiology 70, no. 9 (2019): 830–37. http://dx.doi.org/10.1177/0003319719844678.

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Cytokines play an important role in the pathogenesis of abdominal aortic aneurysm (AAA). We evaluated the cytokine expression profile of large AAA walls using a 274-cytokine protein array. We hypothesized that AAAs are characterized by an inflammatory, chemotactic cytokine profile. We investigated the cytokine expression profile of 12 patients with AAA and 6 nonaneurysmal controls using an antibody-based protein array. The array generated antibodies against homogenized human aortic tissues to validate the cytokines differentially expressed in AAAs and normal aortas. Data were quantified using

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17

Hong, Chang-Sook, Brenda Diergaarde, and Theresa L. Whiteside. "Abstract PO-096: Cytokines in the lumen of exosomes are undetectable by immunoassays distorting cytokine profiles in HNC patients and healthy donors." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—096—PO—096. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-096.

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Abstract Background: Exosomes, now called small extracellular vesicles (sEV), play a key role in cell-to-cell signaling. They are produced by all cells, circulate freely and are present in all body fluids. Evidence indicates that biologically active cytokines are present on the surface and/or in the lumen of sEV. The contributions of intra-vesicular cytokines to cytokine levels in plasma of cancer patients are unknown. Methods: sEV were isolated by ultrafiltration/size exclusion chromatography from pre-cleared plasma obtained from 30 patients with head and neck squamous cell carcinoma (HNSCC)

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18

Li, Yuan, Dan Yang, Bo Sun, et al. "Discovery of crucial cytokines associated with abdominal aortic aneurysm formation by protein array analysis." Experimental Biology and Medicine 244, no. 18 (2019): 1648–57. http://dx.doi.org/10.1177/1535370219885101.

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As a common disease, abdominal aortic aneurysm (AAA) features permanently progressively dilated abdominal aorta. Various cytokines are implicated in AAA pathogenesis. Clarification of involved cytokines combined with functional analysis may provide new insights into AAA pathogenesis. Using a mouse model, this study analyzed the cytokine profiles in AAA. Cytokines were measured in AAA tissues of saline control or angiotensin II-treated ApoE−/− mice using an antibody array of 200 cytokines, cytokine receptors, and related proteins. Statistical analysis revealed that 21 of 200 proteins were diffe

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19

Kim, Yong-Ku, and Michael Maes. "The role of the cytokine network in psychological stress." Acta Neuropsychiatrica 15, no. 3 (2003): 148–55. http://dx.doi.org/10.1034/j.1601-5215.2003.00026.x.

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Although a considerable amount of evidence has shown that psychological stress alters peripheral and brain cytokines, the physiological significance of cytokine alteration in psychological stress remains to be elucidated. The aims of this review are to analyze the influence of acute and chronic psychological stresses on the cytokine network in animals and in humans, and to explore the pathophysiological implication of the cytokine changes in psychological stress. Acute psychological stress may increase proinflammatory cytokines both in animals and in humans, and increase T-helper-1 cell cytoki

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20

Cui, Ang, Teddy Huang, Shuqiang Li, et al. "Systematic dissection of cytokine responses in vivo at single-cell resolution." Journal of Immunology 206, no. 1_Supplement (2021): 106.13. http://dx.doi.org/10.4049/jimmunol.206.supp.106.13.

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Abstract Cytokines mediate a highly complex intercellular signaling network in health and disease. While many individual cytokines have been studied in-depth, we do not have a systems-level view of cell-type-specific responses to each cytokine and do not yet understand how cytokines orchestrate cell-cell communication networks in a complex immune response. To address these two gaps in cytokine biology, we performed single-cell RNA sequencing to measure gene expression profiles of over 20 mouse lymph node cell populations in response to over 80 cytokines in vivo. We first investigated how disti

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21

Cai, Rui. "Progress in the application of cytokines in lung cancer treatment." Highlights in Science, Engineering and Technology 74 (December 29, 2023): 378–85. http://dx.doi.org/10.54097/zq3ga069.

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Lung cancer is the most common cancer today and has become the leading cause of cancer death worldwide. Previous common therapy of this disease mainly include surgery, radiation therapy, chemotherapy etc., and the recently most focused solution of immunotherapy, therapy making use of immunity agents such as vaccines, monoclonal antibodies and cytokines. Cytokines, such as gefitinib, the epidermal growth factor receptor inhibitor, and bevacizumab, the VEGF inhibitor, have been widely used in the clinic as targets for the treatment of lung cancer. Another application of cytokines in the treatmen

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22

Debets, R., and H. F. J. Savelkoul. "Cytokines as cellular communicators." Mediators of Inflammation 5, no. 6 (1996): 417–23. http://dx.doi.org/10.1155/s0962935196000579.

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Cytokines and their receptors are involved in the pathophysiology of many diseases. Here we present a detailed review on cytokines, receptors and signalling routes, and show that one important lesson from cytokine biology is the complex and diverse regulation of cytokine activity. The activity of cytokines is controlled at the level of transcription, translation, storage, processing, posttranslational modification, trapping, binding by soluble proteins, and receptor number and/or function. Translation of this diverse regulation in strategies aimed at the control of cytokine activity will resul

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23

Lin, Sheng-Chieh, Li-Shian Shi, and Yi-Ling Ye. "Advanced Molecular Knowledge of Therapeutic Drugs and Natural Products Focusing on Inflammatory Cytokines in Asthma." Cells 8, no. 7 (2019): 685. http://dx.doi.org/10.3390/cells8070685.

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Asthma is a common respiratory disease worldwide. Cytokines play a crucial role in the immune system and the inflammatory response to asthma. Abnormal cytokine expression may lead to the development of asthma, which may contribute to pathologies of this disease. As cytokines exhibit pleiotropy and redundancy characteristics, we summarized them according to their biologic activity in asthma development. We classified cytokines in three stages as follows: Group 1 cytokines for the epithelial environment stage, Group 2 cytokines for the Th2 polarization stage, and Group 3 cytokines for the tissue

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24

Chesnokova, Vera, and Shlomo Melmed. "Minireview: Neuro-Immuno-Endocrine Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis by gp130 Signaling Molecules." Endocrinology 143, no. 5 (2002): 1571–74. http://dx.doi.org/10.1210/endo.143.5.8861.

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Abstract The neuroendocrine and immune systems communicate bidirectionally. The neuro-immune-endocrine interface is mediated by cytokines acting as auto/paracrine or endocrine factors regulating pituitary development, cell proliferation, hormone secretion, and feedback control of the hypothalamic-pituitary-adrenal (HPA) axis. At birth or during neonatal ontogenesis, cytokines produce permanent alterations of HPA axis function and the stress response. Overexpressing IL-6 or leukemia inhibitory factor leads to significant changes in pituitary development and functions. Pituitary corticotroph POM

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25

Feliciani, C., A. K. Gupta, and D. N. Saucier. "Keratinocytes and Cytokine/Growth Factors." Critical Reviews in Oral Biology & Medicine 7, no. 4 (1996): 300–318. http://dx.doi.org/10.1177/10454411960070040101.

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Cytokines are polypeptide growth factors produced by most nucleated cells in the body, including epithelial cells, keratinocytes, and Langerhans cells in the skin. Cytokines can be classified into interleukins, tumor necrosis factors, chemokines, colony-stimulating factor, interferons, and growth factors. Like classic hormones, cytokines bind to specific receptors to transmit their messages to target cells. Cytokine receptors can be divided into three cytokine receptor superfamilies: the immunoglobulin superfamily, the hematopoietin family, and the tumor necrosis factor family. Following cytok

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26

Borge, Bengt Åge Sørby, Karl-Henning Kalland, Sue Olsen, Athanasia Bletsa, Ellen Berggreen, and Helge Wiig. "Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 3 (2009): H735—H744. http://dx.doi.org/10.1152/ajpheart.01309.2008.

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Cytokines act as chemical mediators during the inflammatory process. Measurements of cytokine levels in tissue have previously been performed in homogenized tissue, but the true concentrations in native interstitial fluid (ISF), i.e., the compartment where cytokines exert their biologically active role, have remained unknown. The role of skeletal muscle myocytes as a source for cytokines during endotoxemia was explored by collecting muscle ISF using a wick method, and the levels of 14 cytokines in ISF and plasma were related to the corresponding changes in mRNA levels to reveal any potential d

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27

Drutskaya, M. S., E. O. Gubernatorova, E. A. Gorshkova, et al. "Cytokines, reverse genetics and anti-cytokine therapy." Bulletin of Siberian Medicine 18, no. 1 (2019): 38–48. http://dx.doi.org/10.20538/1682-0363-2019-1-38-48.

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Cytokines comprise the molecular language of communication between the cells, which is needed to maintain the homeostatic functions of the body (including the immune system) and mediate various diseases. Many aspects of inflammation, autoimmune diseases and neoplasia are associated with cytokine signaling through specific receptors. The establishment of new physiological functions of “old” cytokines and understanding the molecular and cellular mechanisms of their involvement in disease pathogenesis, as well as the search for new therapeutic targets and development of innovative approaches to a

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28

Kovanen, Panu E., and Warren J. Leonard. "Cytokine signaling: Inhibitors keep cytokines in check." Current Biology 9, no. 23 (1999): R899—R902. http://dx.doi.org/10.1016/s0960-9822(00)80079-2.

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29

Lucey, D. R., M. Clerici, and G. M. Shearer. "Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases." Clinical Microbiology Reviews 9, no. 4 (1996): 532–62. http://dx.doi.org/10.1128/cmr.9.4.532.

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In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+ helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation of human Th1 and Th2 clones by Romagnani and coworkers in the early 1990s has led to a large number of reports on the effects of Th1 and Th2 on the human immune system. More recently, cells other than CD4+ T cells, including CD8+ T cells, monocytes, NK cells, B cells, eosinophils, mast cells, basophils, and other cells, have been shown to be capable of producing "Th1" and "Th2" cytokines. In this review, we examine the

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30

Alvarez-Rodríguez, L., M. Lopez-Hoyos, C. Mata, et al. "Circulating cytokines in active polymyalgia rheumatica." Annals of the Rheumatic Diseases 69, no. 01 (2009): 263–69. http://dx.doi.org/10.1136/ard.2008.103663.

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Objective:To characterise the circulating cytokine profile and the cellular source of circulating cytokines in polymyalgia rheumatica (PMR).Methods:The study included 34 patients with active untreated PMR and 17 age-matched healthy controls (HC). Circulating cytokines were measured by cytometric bead array and ELISA. Intracellular cytokines were assessed in CD3+ and CD14+ cells by flow cytometry. Cytokines in cell culture supernatants were also determined after polyclonal stimulation of patients’ peripheral blood mononuclear cells.Results:Circulating levels of interleukin-6 (IL6) were signific

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31

Maecker, Holden T., Weiqi Wang, Yael Rosenberg-Hasson, Richard C. Semelka, Joseph Hickey, and Lorrin M. Koran. "An initial investigation of serum cytokine levels in patients with gadolinium retention." Radiologia Brasileira 53, no. 5 (2020): 306–13. http://dx.doi.org/10.1590/0100-3984.2019.0075.

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Abstract Objective: To determine whether individuals with proposed gadolinium deposition disease (GDD) have elevated serum levels of pro-inflammatory and pro-fibrotic cytokines, and whether specific cytokines are correlated with certain symptoms. Materials and Methods: Twenty-four participants recruited between May 2016 and June 2017 met GDD diagnostic criteria. The 64 control subjects provided serum samples before prophylactic flu vaccination. Serum cytokine levels were obtained with Luminex serum cytokine assay using eBiosciences/Affymetrix human 62-plex kits. Wilcoxon rank-sum tests were pe

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32

Plata-Salamán, Carlos R. "Cytokines and Feeding." Physiology 13, no. 6 (1998): 298–304. http://dx.doi.org/10.1152/physiologyonline.1998.13.6.298.

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Cytokines inhibit feeding through peripheral and brain mechanisms. Behavioral, cellular, and molecular studies show that interactions among cytokines, neurotransmitters, and peptides and modulation of hypothalamic neurons are involved in cytokine-induced feeding inhibition. This action of cytokines is relevant to the control of feeding in health and disease.

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33

Plata-Salaman, Carlos R. "Brain cytokines and disease." Acta Neuropsychiatrica 14, no. 6 (2002): 262–78. http://dx.doi.org/10.1034/j.1601-5215.2002.140602.x.

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Cytokines (e.g. various interleukins and subfamily members, tumor necrosis factors, interferons, chemokines and growth factors) act in the brain as immunoregulators and neuromodulators. Over a decade ago, the integrative article ‘Immunoregulators in the Nervous System’ (Neurosci Biobehav Rev1991; 15: 185–215) provided a comprehensive framework of pivotal issues on cytokines and the nervous system that recently have been extensively studied. Cytokine profiles in the brain, including cytokine generation and action, have been studied in multiple models associated with neuropathophysiological cond

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34

Simbirtsev, A. S. "Immunopharmacological aspects of the cytokine system." Bulletin of Siberian Medicine 18, no. 1 (2019): 84–95. http://dx.doi.org/10.20538/1682-0363-2019-1-84-95.

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Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of

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35

Olbei, M., J. Thomas, I. Hautefort, et al. "P090 Unraveling the rewiring of cytokine signalling in Inflammatory Bowel Disease using a novel network biology approach." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i189. http://dx.doi.org/10.1093/ecco-jcc/jjab232.219.

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Abstract Background Intercellular communication mediated by cytokines is critical to the development of immune responses, particularly in the context of chronic immune-mediated disorders such as inflammatory bowel disease (IBD). By releasing these small molecular weight peptides, the source cells can influence numerous intracellular processes in the target cells, including the secretion of other cytokines downstream. However, there are no readily available resources and studies modelling cytokine-cytokine interactions that would be important for better understanding the dysregulation of cytoki

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36

Cannon, J. G., J. L. Nerad, D. D. Poutsiaka, and C. A. Dinarello. "Measuring circulating cytokines." Journal of Applied Physiology 75, no. 4 (1993): 1897–902. http://dx.doi.org/10.1152/jappl.1993.75.4.1897.

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Cytokines, i.e., regulatory proteins derived primarily (but not exclusively) from cells of the immune system, are receiving increasing attention for their influences on physiological processes. This paper outlines several of the unique characteristics of cytokines and discusses the pitfalls encountered when measuring them in biological fluids. At present, each available assay has a combination of advantages and drawbacks; therefore, investigators must be aware of the trade-offs and choose the assay that best addresses their needs. The factors that affect cytokine measurement also influence cyt

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37

Olson, Matthew Richard, and Mark H. Kaplan. "Autocrine and paracrine cytokine feedback augment the production of Th2-associated cytokines." Journal of Immunology 196, no. 1_Supplement (2016): 191.22. http://dx.doi.org/10.4049/jimmunol.196.supp.191.22.

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Abstract The Type 2 cytokines (including cytokines from Th2 and Th9 cells) play a critical role in priming of the humoral response, immunity to parasites, and the induction of allergic disease. It has been proposed that unlike Type 1 cytokines (i.e. IFN-γ), the induction of Type 2 cytokines is cell autonomous and requires no additional signals for optimal cytokine production. Contrary to this notion, we found that the addition of golgi transport inhibitors that block cytokine secretion (i.e. monensin (Mon) and brefeldin A (BFA)) during stimulation significantly impaired the induction of Type 2

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38

Dieleman, L. A., C. O. Elson, G. S. Tennyson, and K. W. Beagley. "Kinetics of cytokine expression during healing of acute colitis in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 1 (1996): G130—G136. http://dx.doi.org/10.1152/ajpgi.1996.271.1.g130.

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The mechanisms of wound healing in the gut are poorly understood but are mediated by cytokines in other tissues. In this study we wanted to determine which cytokines were expressed after nonspecific colonic injury, the kinetics of that expression, and how cytokine expression correlated with tissue histology. At 0, 4, 8, 12, 24, 48, and 72 h after intrarectal administration of 3% acetic acid to C3H/HeJ mice, their colons were removed for histology, organ culture, and RNA extraction. Cytokine mRNA expression for various cytokines was assessed by reverse transcriptase-polymerase chain reaction wi

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Zheng, Song, and Wu Wang. "Proinflammatory cytokine and cancer." American Journal of BioMedicine 4, no. 3 (2016): 240–55. http://dx.doi.org/10.18081/2333-5106/016-240-255.

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Many investigators have suggested that different cytokines may be important players in the development and progression of cancer and tumor biology. Cytokines are integral to many different aspects of cancer, including development/advancement, treatment, and prognosis. However, so far most cytokine -based therapy trials have fallen short of expectations. One of main obstacles is the difficulty to achieve therapeutically relevant dosage in patients without generating excessive normal tissue toxicity. Furthermore, cytokine profile levels have been used to predict cancer prognosis as differential

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Townsend, M. J., and A. N. McKenzie. "Unravelling the net? cytokines and diseases." Journal of Cell Science 113, no. 20 (2000): 3549–50. http://dx.doi.org/10.1242/jcs.113.20.3549a.

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The Cytokine Network edited by Fran Balkwill Frontiers in Molecular Biology Series (seried editors B. D. Hames and D. M. Glover) Oxford University Press (2000) pp. 199. ISBN 019–963-702-4. 29.95 Cytokines are small- to medium-sized proteins and glycoproteins that mediate highly potent biological effects on many cell types. They have critical roles in haematopoiesis, inflammatory responses and the development and maintenance of immune responses. Importantly, cytokines act in networks or cascades. Typical properties of cytokines in these networks are pleiotropy, redundancy, synergistic activity

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Nikovics, Krisztina, Anne-Laure Favier, Mathilde Rocher, et al. "In Situ Identification of Both IL-4 and IL-10 Cytokine–Receptor Interactions during Tissue Regeneration." Cells 12, no. 11 (2023): 1522. http://dx.doi.org/10.3390/cells12111522.

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Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process. Determining the orchestration of cytokine interactions with their receptors on their cellular targets is essential to fully understanding the process of inflammation and tissue regeneration. To this end, we have investigated the interactions of Interleukin-4 cytokine (IL-4)/Interleukin-4 cytokine receptor (IL-4R) and Interleukin-10 cytokine (IL-10)/Interleukin-10 cytokine receptor (IL-10R) using in si

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Dueck, Amylou C., Charles S. Cleeland, Robert Dantzer, et al. "Cytokine Profile Changes In 309 Myelofibrosis Patients: Comparison Of JAK1/JAK2 Inhibitor Therapy Vs. Placebo – Correlative Analysis From The Comfort-I Trial." Blood 122, no. 21 (2013): 4074. http://dx.doi.org/10.1182/blood.v122.21.4074.4074.

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Abstract Background Inflammatory deregulation may be a major factor in cancer related symptoms (Dantzer Nature Rev Clin Oncol 2012). Improved symptoms in myelofibrosis (MF) patients treated with single arm ruxolitinib (JAK1/JAK2 inhibitor) studies has been correlated with normalization of selected cytokines increased pre-therapy (c-reactive protein, IL-1ra, MIP-1b, TNF-a, and IL-6; Verstovsek NEJM 2010). We sought to assess the impact of JAK1/JAK2 inhibitor therapy on cytokine levels and the relationship between cytokine levels and symptoms prior to and during JAK1/JAK2 inhibitor therapy in th

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Zhou, Rui, Wangjun Bu, Yudan Fan, et al. "Dynamic Changes in Serum Cytokine Profile in Rats with Severe Acute Pancreatitis." Medicina 59, no. 2 (2023): 321. http://dx.doi.org/10.3390/medicina59020321.

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Background and Objectives: Most published research has only investigated a single timepoint after the onset of severe acute pancreatitis (SAP), meaning that they have been unable to observe the relationship between the dynamic changes in cytokines and SAP progression. In this study, we attempted to reveal the relationship between dynamic changes in cytokine expression levels and SAP disease progression and the relationship between cytokines, using continuous large-scale cytokine detection. Materials and Methods: Seventy rats were randomly assigned to control (Con), sham operation (SO) and SAP

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Corwin, Elizabeth J. "Understanding Cytokines Part I: Physiology and Mechanism of Action." Biological Research For Nursing 2, no. 1 (2000): 30–40. http://dx.doi.org/10.1177/109980040000200104.

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This is the first of a 2-part article on understanding cytokines. Cytokines are intercellular signaling proteins released from virtually all nucleated cells that influence growth and cellular proliferation in a wide range of tissues. Cytokines have immune modulating effects and are understood to control most of the physical and psychological symptoms associated with infection and inflammation. Cytokines also influence reproduction and bone remodeling. Dysregulation of the cytokine cellular system has significant implications in the development of a variety of illnesses, including most autoimmu

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Inchingolo, Francesco, Angelo Michele Inchingolo, Giuseppina Malcangi, et al. "The Interaction of Cytokines in Orthodontics: A Systematic Review." Applied Sciences 14, no. 12 (2024): 5133. http://dx.doi.org/10.3390/app14125133.

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Aim: Cytokines are crucial low-molecular-weight proteins involved in immune responses. This systematic review highlights the need for in-depth studies on cytokines’ biological mechanisms, providing insights into disease onset and potential therapeutic strategies. Materials and methods: A comprehensive literature search identified 18 relevant articles, emphasizing the multifaceted role of cytokines in orthodontic treatment (OT). The quality assessment using the ROBINS-I tool ensures a rigorous evaluation of the included studies, contributing to the overall reliability of the findings. Results a

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Bonner, J. C., and A. R. Brody. "Cytokine-binding proteins in the lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 268, no. 6 (1995): L869—L878. http://dx.doi.org/10.1152/ajplung.1995.268.6.l869.

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Numerous cytokines and growth factors signal the normal processes of tissue maintenance and remodeling in the lung, yet the aberrant expression of these peptide mediators is involved in a variety of pulmonary diseases. Furthermore, several different binding proteins function in controlling the extracellular levels of many of these cytokines in the lung. For example, a variety of cytokines and growth factors bind to and are regulated by the ubiquitous proteinase inhibitor, alpha 2-macroglobulin. The insulin-like growth factors are controlled by a specific class of six different insulin-like gro

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Geoffrey, Abura. "The Dual Role of Cytokines in Immunity: Balancing Pro-Inflammatory and Anti-Inflammatory Responses." INOSR APPLIED SCIENCES 13, no. 1 (2025): 28–34. https://doi.org/10.59298/inosras/2025/13.1.2834000.

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Cytokines are essential mediators in immune regulation, balancing pro-inflammatory and anti-inflammatory responses to maintain homeostasis and combat infections. Pro-inflammatory cytokines, including TNF-α, IL-6, and IFN-γ, initiate and sustain immune activation by enhancing cellular recruitment and promoting antimicrobial activity. Conversely, anti-inflammatory cytokines such as IL-10 and TGF-β mitigate excessive inflammation, preventing tissue damage and fostering immune tolerance. This duality underscores the complex interplay between these cytokine categories, which is crucial for immune s

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Minami, Keita, Yoshiki Yanagawa, Kazuya Iwabuchi, et al. "Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions." Blood 106, no. 5 (2005): 1685–93. http://dx.doi.org/10.1182/blood-2004-12-4738.

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Abstract The ability of extracellular stimuli to modulate dendritic cell (DC) activation of natural killer T (NKT) cells was not well understood. We investigated the effects of the T helper type 1 (Th1)/Th2-cytokine environment on DC induction of NKT cell-mediated cytokine production in mice. Pretreatment of myeloid DCs with Th1 or Th2 cytokines, interleukin (IL)-4 or interferon (IFN)-γ, led to the enhanced production of reciprocal cytokines by NKT cells (eg, IL-4 pretreatment led to the enhanced production of Th1 cytokines) in vitro and in vivo. Thus, the recognition of Th1 or Th2 cytokines b

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Nedospasov, S. A. "Cytokines – regulators of immunity." Vestnik Moskovskogo universiteta. Seria 16. Biologia, no. 2S, 2024 (October 8, 2024): 9–15. http://dx.doi.org/10.55959/msu0137-0952-16-79-2s-3.

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This short review focuses on cytokines, molecular mediators of immunity and many other physiological functions of the body. Research on cytokines revealed new principles of cell-tocell communications and new paradigms in intracellular signal transduction. A few recombinant cytokines and, paradoxically, some cytokine inhibitors found practical use in medicine.

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Tetè, S., D. Tripodi, M. Rosati, et al. "IL-37 (IL-1F7) the Newest Anti-Inflammatory Cytokine Which Suppresses Immune Responses and Inflammation." International Journal of Immunopathology and Pharmacology 25, no. 1 (2012): 31–38. http://dx.doi.org/10.1177/039463201202500105.

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Cytokines such as interleukins, chemokines and interferons are immunomodulating and inflammatory agents, characterized by considerable redundancy, in that many cytokines appear to share similar functions. Virtually all nucleated cells, but especially epithelial cells and macrophages, are potent producers of cytokines. The objective of this study is to review the detailed mechanism of action and the biological profiles of IL-37, the newest anti-inflammatory cytokine. This review focuses on IL-37, a key cytokine in regulating inflammatory responses, mainly by inhibiting the expression, productio

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