Дисертації: "D-ECG"

1

Vaníček, Aleš. "Ambulantní monitor srdečního rytmu." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219463.

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This thesis describes the design and practical realization of a prototype mobile, battery-powered device that is able to periodically recording electrocardiogram and fotopletysmogram or blood pressure. Data from these periodic scanning is processed by microcontroller and stored on a memory card which is part of the proposed device. The device can be connected to a PC via USB like a virtual serial port.

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2

Chamadiya, Bhavin [Verfasser]. "Applications of textile based capacitive ECG recordings / Bhavin Chamadiya." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2012. http://d-nb.info/102926404X/34.

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3

Gruetzmann, Anna [Verfasser]. "Wireless ECG Sensor in Surface Acoustic Wave Transponder Technology / Anna Gruetzmann." München : Verlag Dr. Hut, 2010. http://d-nb.info/1009484524/34.

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4

Khawaja, Antoun [Verfasser]. "Automatic ECG analysis using principal component analysis and wavelet transformation / von Antoun Khawaja." Karlsruhe : Univ.-Verl. Karlsruhe, 2007. http://d-nb.info/985224770/34.

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5

Campitelli, Marcelo Adrián. "Compressão de sinais ECG utilizando DWT com quantização não-linear e por sub-bandas." reponame:Repositório Institucional da UnB, 2015. http://dx.doi.org/10.26512/2015.12.D.19564.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Tecnologia, Departamento de Engenharia Elétrica, 2015.
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Com o desenvolvimento cada vez mais intenso da tecnologia de dispositivos biomédicos, há cada vez mais acesso aos sinais bioelétricos, o que permite grande avanço na realização de diagnósticos, planejamento de tratamentos e monitoração de pacientes. Particularmente, o eletrocardiograma (ECG) tem sido usado para muitos propósitos. Além disso, novas formas simples e de baixo custo para adquirir o ECG tem sido descobertas. Entretanto, esses avanços exigem o melhoramento dos processos de codificação do sinal de ECG, de forma a permitir seu armazenamento e transmissão eficientemente em termos de requisitos de memória e consumo de energia. Neste contexto, o presente trabalho propõe duas contribuições. Em primeiro lugar, apresenta um algoritmo de compressão de sinais ECG, utilizando transformadas wavelets, e propondo um processo de quantização novo, não encontrado na literatura. Nesse processo, a transformação é realizada utilizando a transformada discreta de wavelets (DWT) e a quantização consiste em um re-ordenamento não-linear das magnitudes dos coeficientes transformados (correção gamma) em conjunto com uma quantização por sub-bandas. A segunda contribuição consiste num estudo sistemático do desempenho das diferentes famílias de wavelets nos resultados obtidos pelo algoritmo proposto, calculando também os parâmetros ótimos de quantização para cada família wavelet utilizada. Para a análise desses métodos, foram realizados testes avaliando o desempenho do algoritmo proposto e comparando os resultados com outros métodos apresentados na literatura. Nesses testes, foram usados como referências os sinais da base de dados do Instituto de Tecnologia de Massachusetts e do Hospital Beth Israel de Boston (MIT-BIH). Uma parcela do banco de dados foi utilizada para otimizar os parâmetros de cada família wavelet no algoritmo proposto, e o desempenho final foi avaliado com todos os sinais restantes. Especificamente, para o sinal 117 do MIT-BIH, que é o sinal mais utilizado para comparar resultados na literatura, o método proposto levou a um fator de compressão (CR) de 11,40 e uma raiz da diferença média percentual (PRD) de 1,38. Demonstrou-se que o algoritmo gera melhores resultados de compressão quando comparado com a maioria dos métodos do estado-da-arte. Também se destaca a simplicidade na implementação do algoritmo em relação a outros encontrados na literatura.
With the increasing development of biomedical devices technology, there is more access to bioelectrical signals. That allows great advances in reaching diagnostics, planning treatments and monitoring patients. Particularly, the electrocardiogram (ECG) has been used for many purposes. Besides that, simple and low-cost ways to acquire the ECG have been found. Nevertheless, those advances require the improvement of the ECG signal coding processes, in a way that allows its efficient storage and transmission in terms of memory requirements and energy consumption. In this context, this dissertation proposes two contributions. Firstly, it presents an ECG signal compression algorithm, using wavelet transforms, and proposing a novel quantization process, not found in the literature. In said process, the transformation is done using the discrete wavelet transform (DWT) and the quantization consists of a non-linear re-ordering of the transformed coefficients magnitudes (gamma correction) in tandem with a sub-band quantization. The second contribution consists in a systematic study of the performance of the different wavelet families through the results obtained by the proposed algorithm, also calculating the optimum quantization parameters for each wavelet family. For the analysis of these methods, tests were done evaluating the performance of the proposed algorithm, comparing its results with other methods presented in the literature. In said tests, signals from the Massachusetts Institute of Technology and Boston’s Beth Israel Hospital database (MIT-BIH) were used as reference. A part of the database was utilized to optimize the parameters of each wavelet family, and the final performance was evaluated with the remaining signals from the database. Specifically, for signal 117 of the MIT-BIH database, which is the most used signal to compare results in the literature, the proposed method led to a compression factor (CR) of 11,40 and a percentage root-mean-square difference (PRD) of 1,38. It was demonstrated that the algorithm generates better compression results when compared to the majority of state-of-the-art methods. The simplicity of the algorithm’s implementation also stands out in relation to other algorithms found in the literature.

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6

Herz, Franziska [Verfasser], Matthias [Akademischer Betreuer] Gutberlet, Lukas [Akademischer Betreuer] Lehmkuhl, Thomas [Gutachter] Kahn, and Ardawan [Gutachter] Rastan. "Diagnostic performance of prospectively ECG triggered versus retrospectively ECG gated 64-slice computed tomography coronary angiography in a heterogeneous patient population / Franziska Herz ; Gutachter: Thomas Kahn, Ardawan Rastan ; Matthias Gutberlet, Lukas Lehmkuhl." Leipzig : Universitätsbibliothek Leipzig, 2012. http://d-nb.info/1238020720/34.

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7

Baumgarten, Kai [Verfasser], Constantin [Akademischer Betreuer] Czekelius, and Klaus [Gutachter] Schaper. "Synthese und Evaluierung von ECG-Derivaten / Kai Baumgarten ; Gutachter: Klaus Schaper ; Betreuer: Constantin Czekelius." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1188882171/34.

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8

Hofer, Armin [Verfasser]. "Einfluss einer eCG-Applikation im Puerperium auf die Fruchtbarkeit von Fleckvieh-Milchkühen / Armin Hofer." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1209159783/34.

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9

Gazbour, Nouha. "Intégration systémique de l’éco-conception dès la phase de R&D des technologies photovoltaïques." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAT018/document.

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Face aux enjeux environnementaux actuels, s’investir dans les énergies renouvelables au nom de la « transition énergétique » est l’alternative la plus adoptée par de nombreux pays. Les énergies renouvelables, en particulier l’énergie photovoltaïque, sont ainsi devenues des secteurs concurrentiels innovants en pleine expansion. Dans ce contexte, il est donc nécessaire de s'assurer que les nouvelles technologies PV, qui sont complexes et issues de plusieurs étapes de fabrication, répondent aux critères d'un produit peu impactant pour l’environnement, dénommé ici éco-conçu. L’état de l’art sur l’éco-conception montre que la prise en compte des contraintes environnementales dans les projets de R&D à échelle TRL « Technology Readiness Level » bas est encore un phénomène émergent, pour les raisons suivantes : d’une part l’évaluation de l’impact environnemental est relativement complexe pour une technologie non mature en cours de développement (TRL bas) ; ses caractéristiques et procédés de fabrication n’étant pas encore tous connus ; d’autre part les outils identifiés présentent plusieurs écueils qui limitent leur intégration dans les organismes PV de R&D.Ce travail de recherche vise donc à développer une méthodologie pour permettre l’intégration pérenne de l’éco-conception dans les organismes de R&D, pour accompagner leurs partenaires industriels dans leur effort d’innovation et de compétitivité.La méthode développée est ainsi basée sur le principe d’estimation des taux d’évolutions techniques, économiques et environnementales d’une nouvelle technologie (TRL bas) par l’intermédiaire d’une base de données de référence. La construction de cette dernière s’appuie sur l’Analyse du Cycle de Vie (ACV) comme outil de pilotage pour fournir des résultats fiables, malgré le faible niveau TRL.Pour intégrer de façon pérenne cette approche au sein des organismes de R&D, la méthode développée a été implémentée dans un outil informatique « ECO PV » dédié aux systèmes PV en silicium cristallin, qui constituent plus de 90% du marché PV actuel. Basé sur le principe de démocratisation des connaissances environnementales et de la capitalisation des informations, cet outil est accessible non seulement aux experts en ACV mais aussi à l’ensemble des ingénieurs du domaine PV.Ce travail de recherche a enfin permis d’une part de générer des premiers résultats à la fois fiables, simples et quantifiés, et de développer une méthodologie d’éco-conception pour orienter les choix technologiques des projets dans les phases amont de R&D, afin de développer des systèmes PV plus respectueux de l’environnement
Faced with current environmental challenges, investing in renewable energies in the name of the "energy transition" is the alternative most adopted by many countries. Renewable energies, in particular photovoltaic solar (PV) energy, have thus become innovative and competitive sectors in full expansion. In this context, it is therefore necessary to ensure that new PV technologies, which are complex and the result of several manufacturing stages, meet the criteria of a product with low environmental impact, referred here as eco-designed.The state of the art on eco-design shows that the consideration of environmental constraints in R&D projects with low TRL "Technology Readiness Level" is still an emerging phenomenon, for two main reasons. On the one hand, environmental impact assessment is relatively complex for a non-mature technology under development (TRL low) because its characteristics and manufacturing processes are not yet fully defined. On the other hand, the identified tools in the literature have several limitations that impede their appropriation in R&D organizations.This research work therefore aims to develop a methodology to enable the sustainable integration of eco-design into R&D organizations, supporting their industrial partners in innovation and competitiveness. Thus, the developed method is based on the estimation of the evolution rate of technical, economic and environmental criteria of a new technology (low TRL) through a specific database of reference. The construction of the database relies on Life Cycle Assessment (LCA), used as a management tool to provide reliable results, despite the low TRL level.To integrate this approach into R&D organizations in a sustainable way, the method developed was implemented in a software "ECO PV" dedicated to crystalline silicon PV systems, which represent more than 94% of the current PV market today. Based on the principle of democratization of environmental knowledge and capitalization of information, this tool is accessible not only to LCA experts but also to all engineers in the PV field.Finally, this research work enabled to generate reliable, simple and quantified results and to develop an eco-design methodology to guide the technological choices of projects in the upstream phases of R&D, in order to develop PV systems more environmentally friendly

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10

Khodadadian, Sharifabad Mehrdad [Verfasser]. "Einsatz von equinem Choriongonadotropin (eCG) beim Rind post partum zur Förderung der Ovaraktivität / Mehrdad Khodadadian Sharifabad." Gießen : Universitätsbibliothek, 2017. http://d-nb.info/1123931291/34.

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11

Baas, Tobias [Verfasser], and O. [Akademischer Betreuer] Dössel. "ECG Based Analysis of the Ventricular Repolarisation in the Human Heart / Tobias Baas ; Betreuer: O. Dössel." Karlsruhe : KIT Scientific Publishing, 2012. http://d-nb.info/118449262X/34.

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12

Wang, Yishan Verfasser], Stefan [Akademischer Betreuer] [Heinen, and Steffen [Akademischer Betreuer] Leonhardt. "Low power wearable wireless ECG system for long-term homecare / Yishan Wang ; Stefan Heinen, Steffen Leonhardt." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1156923409/34.

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Wang, Yishan [Verfasser], Stefan [Akademischer Betreuer] Heinen, and Steffen [Akademischer Betreuer] Leonhardt. "Low power wearable wireless ECG system for long-term homecare / Yishan Wang ; Stefan Heinen, Steffen Leonhardt." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1156923409/34.

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14

Rockstroh, Christian [Verfasser], Bernhard [Akademischer Betreuer] Hensel, and Björn [Akademischer Betreuer] Eskofier. "Novel algorithms and rating methods for high-performance ECG classification / Christian Rockstroh. Gutachter: Bernhard Hensel ; Björn Eskofier." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2013. http://d-nb.info/1054165254/34.

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15

Brack, Eva. "Einfluss von Surfactantprotein A und D auf die ECP-Degranulation von humanen eosinophilen Granulozyten." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-160799.

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Die Rolle, die die hydrophoben Surfactantproteine SP-A und SP-D welche in den oberflächlichen Atemwegsflüssigkeiten zu finden sind spielen lässt sich wie folgt zusammenfassen. Zum einen, eine wichtige immunologische Funktion, indem sie zur Abwehr von Erregern beitragen. Zum anderen, bei der Regulation allergischer Reaktionen, bei welcher der eosinophile Granulozyt mit den von ihm freigesetzten Entzündungsmediatoren als wichtigste Effektorzelle zu nennen ist. Ziel dieser Arbeit war es den Einfluss der Surfactantproteine A und D auf eosinophile Granulozyten in Bezug auf ihre ECP-Degranulation zu untersuchen. In verschiedenen Versuchsreihen wurde die Freisetzung von Eosinophilem kationischem Protein (ECP) ohne (native Zellen) und nach Stimulation der Zellen mittels Fluoreszenzassay gemessen. Als Stimulanzien kamen Ca-Ionophore A23187 als eine potenter, wenn auch unphysiologischer Zellstimulus und die Immunglobuline A und G, sowie das Serum eines Allergikers als physiologische Stimuli zum Einsatz. Die Ergebnisse zeigten, dass durch die Surfactantproteine selbst keine Aktivierung der ECP-Freisetzung aus nativen eosinophilen Zellen ausgelöst werden kann. Die Degranulation stimulierter Zellen hingegen kann durch natürliches SP-A, SP-D und rekombinantes SP-D reduziert werden. Die wirksamen SP-D Konzentrationen lagen zwischen 0,05 und 5000ng/ml, wenn die Zellen mit Ca-Ionophore stimuliert wurden. Wurden IgA und IgG als Stimuli verwendet, konnte die ECP-Degranulation durch SP-A, SP-D und rekombinantes SP-D ebenfalls gehemmt werden, zeigte sich jedoch in keiner Konzentration signifikant. Bei der Stimulation mit Allergikerserum zeigten sowohl SP-A, SP-D als auch rekombinantes SP-D eine hemmende Wirkung. Zusammenfassend zeigen unsere In-vitro-Ergebnisse eine inhibitorische Wirkung von SP-A und D auf die ECP-Degranulation aus stimulierten eosinophilen Granulozyten. Dies ist mit der Hypothese einer protektiven Wirkung dieser Surfactantproteine bei Erkrankung aus dem allergischen Formenkreis vereinbar.

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16

Oliva, Justine. "Eco-épidémiologie du virus influenza D : évaluation du spectre d'hôtes et du risque d'émergence." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30171.

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Des études récentes ont mis en évidence un nouveau genre de virus appartenant à la famille des Orthomyxoviridae, le virus influenza D (IDV). Depuis sa découverte, des études ont montré que ce virus circule sur différents continents et infecte différentes espèces animales. À ce jour, le bovin est considéré comme l'hôte principal du virus. Dans cette thèse, nous nous sommes intéressés à la circulation géographique et au spectre d'hôtes d'IDV, ainsi qu'à sa pathogénicité. L'évaluation du spectre d'hôtes et de la circulation géographique du virus a été menée grâce à des études sérologiques et/ou virologiques sur des cohortes de différentes espèces domestiques en France, au Luxembourg et en Afrique, ainsi que sur des cohortes d'espèces de la faune sauvage et captive de différents pays. Les résultats suggèrent qu'IDV circule de manière plus importante chez les bovins que chez les autres espèces. Par ailleurs, les souches françaises sont génétiquement proches des autres souches européennes, suggérant la circulation d'un même lignage sur le continent. De plus, les camélidés, les marsupiaux ainsi que les cervidés pourraient être de nouveaux hôtes pour le virus. Enfin, un modèle murin a été développé afin d'étudier la pathogénicité du virus. Le pouvoir pathogène d'IDV chez la souris semble faible, bien que des similitudes aient été observées avec un modèle d'infection expérimentale chez le veau. En conclusion, IDV circule mondialement et semble posséder un large spectre d'hôte. Le développement d'un modèle murin d'infection avec IDV nous a permis d'apporter des éléments de réponse sur la pathogénicité du virus, et notamment sur sa réplication de celui-ci et la réponse immunitaire associée
Recently, a novel genus was identified within the Orthomyxoviridae family and named thereafter Influenza D virus (IDV). So far, IDV has been detected on differents continents and differents species are susceptible to the virus. Bovine are considered as a main host for IDV. The PhD was divided in two parts: (i) assessment of the host ranges and the geographical circulation of IDV, and (ii) development of a murine model in order to study the pathogenesis of IDV. First, the host range and geographical circulation of IDV were analyzed using serological and/or virological tools, on domestic species from France, Luxembourg and Africa; but also in wild fauna species from differents countries. We observed that IDV circulates mainly in bovine, but other species, such as swine or small ruminants, seem susceptible to the virus too. Virological and phylogenic analyses demonstrated that IDV strains circulating in France are genetically close to European viral strains. Moreover, it appears that camelids, cervids and marsupials could be new hosts for the virus. Finally, we developed a murine model in order to better understand the pathogenesis of the virus. The results suggest that IDV presents a low pathogenesis in mice compared to what was observed in the calf model, although similarities have been observed. In conclusion, IDV circulates throughout the world and seems to have a wide host range, which includes species from the wild fauna. Moreover, the murine model allowed us to better understand of IDV's pathogenesis, especially its replication (fitness, tropism) and associated immune response

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17

Cluzel, François. "Eco-design implementation for complex industrial system : From scenario-based LCA to the definition of an eco-innovative R&D projects portfolio." Phd thesis, Ecole Centrale Paris, 2012. http://tel.archives-ouvertes.fr/tel-00760580.

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Face to the growing awareness of environmental concerns issued from human activities, eco-design aims at offering a satisfying answer in the products and services development field. However when the considered products become complex industrial systems, there is a lack of adapted methodologies and tools. These systems are among others characterised by a large number of components and subsystems, an extremely long and uncertain life cycle, or complex interactions with their geographical and industrial environment. This change of scale actually brings different constraints, as well in the evaluation of environmental impacts generated all along the system life cycle (data management and quality, detail level according to available resources...) as in the identification of adapted answers (management of multidisciplinary aspects and available resources, players training, inclusion in an upstream R&D context...). So this dissertation aims at developing a methodology to implement ecodesign of complex industrial systems. A general methodology is first proposed, based on a DMAIC process (Define, Measure, Analyse, Improve, Control). This methodology allows defining in a structured way the framework (objectives, resources, perimeter, phasing...) and rigorously supporting the ecodesign approach applied on the system. A first step of environmental evaluation based on Life-Cycle Assessment (LCA) is thus performed at a high systemic level. Given the complexity of the system life cycle as well as the exploitation variability that may exist from one site to another, a scenario-based approach is proposed to quickly consider the space of possible environmental impacts. Scenarios of exploitation are defined thanks to the SRI (Stanford Research Institute) matrix and they include numerous elements that are rarely considered in LCA, like preventive and corrective maintenance, subsystems upgrading or lifetime modulation according to the economic context. At the conclusion of this LCA the main impacting elements of the system life cycle are known and they permit to initiate the second step of the eco-design approach centred on environmental improvement. A multidisciplinary working group perform a creativity session centred on the eco-design strategy wheel (or Brezet wheel), a resource-efficient eco-innovation tool that requires only a basic environmental knowledge. Ideas generated during creativity are then analysed through three successive filters allowing: (1) to pre-select and to refine the best projects; (2) to build a R&D projects portfolio thanks to a multi-criteria approach assessing not only their environmental performance, but also their technical, economic and customers' value creation performance; (3) to control the portfolio balance according to the company strategy and the projects diversity (short/middle/long term aspect, systemic level...). All this work was applied and validated at Alstom Grid on electrical conversion substations used in the primary aluminium industry. The methodology deployment has allowed initiating a robust eco-design approach recognized by the company and finally generating a portfolio composed of 9 eco-innovative R&D projects that will be started in the coming months.

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18

Silveira, Luciana Carvalho. "O polimorfismo I/D do gene ECA e nefropatia diabética: evidências baseadas em meta-análises." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8667.

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Diabetic Nephropathy (DN) is a microvascular renal complication of Diabetes Mellitus (DM), characterized by increased albuminuria and progressive loss of renal function. A cumulative incidence of ND in the last 10 years was observed in 40%, mainly in patients with type 2 diabetes mellitus (T2DM), being an important cause of morbidity and mortality among these individuals. The Insertion / Deletion (I/D) polymorphism in the ACE gene could influence the predisposition to DN by vascular modulation in the kidney, through a direct effect on the cellular hypertrophy, influencing the proliferation and the rupture of the extracellular matrix. Many studies about this subject are discordant, a fact that increases the need for joint analysis so that safe conclusions can be generated. The aim of this study was to investigate the association between ACE gene I/D polymorphism and the development of DN in patients with T2DM. Through a standardized research protocol, the bibliographic search was performed in the PubMed and Cochrane Library electronic databases of 1995-2017, selecting case-control observational studies using the terms "polymorphism" AND " ACE gene" AND “diabetic nephropathy ". We included 33 studies in qualitative synthesis and 30 studies for meta- analysis, with 9.077 participants with T2DM genotyped, 4.774 (52, 6%) individuals with DN and 4.303 (47. 4%) individuals without DN. Evaluated separately, the genotypes for the case group, we have I/I (23, 5%), I/D (46, 4%) and D/D (30, 6%). The genotypes for the control group, I/I (28, 6%), I/D (46.19%) and D/D (25%). The highest prevalence observed was of the I/D genotype in both groups. In the allele frequencies calculated by the Hardy-Weinberg Test, the mutant D allele presents with 54% in the case group and 48% in the control group. The wild-type I allele was present in 46% in the case group and 52% in the control group. The present meta-analysis concludes the I/D polymorphism of the ACE gene studied through the I/D and D/D genotypes is not associated with the risk of developing DN in individuals with T2DM, but the presence of the D allele has significant significance in the risk of developing the disease, as well as the protective role of the I allele.
A Nefropatia Diabética (ND) é uma complicação microvascular renal do Diabetes Mellitus (DM), caracterizada pelo aumento da albuminúria e perda progressiva da função renal. Nos últimos 10 anos, observa-se uma incidência cumulativa de 40%, principalmente em pacientes com diabetes mellitus tipo 2 (DM2) sendo uma causa importante de morbimortalidade. O polimorfismo Inserção / Deleção (I/D) no gene ECA poderia influenciar a predisposição para ND por modulação vascular no rim, através de um efeito direto sobre a hipertrofia celular, influenciando a proliferação e a ruptura da matriz extracelular. Estudos mostram discordância, fato que aumenta a necessidade de análises conjuntas para que se possam gerar conclusões seguras. O objetivo do estudo foi investigar a associação entre o polimorfismo I/D do gene ECA e o desenvolvimento de ND em pacientes com DM2. Através de um protocolo de pesquisa padronizado, realizou-se a busca bibliográfica nos bancos de dados eletrônicos PubMed e Cochrane Library de 1995-2017, selecionando estudos observacionais do tipo caso-controle, usando os termos "polymorphism" AND "ACE gene" AND "diabetic nephropathy". Incluiu-se 33 estudos na síntese qualitativa e 30 estudos na meta-análise, sendo 9.077 participantes com DM2 genotipados, 4.774 (52, 6%) indivíduos com ND e 4.303 (47,4%) indivíduos sem ND.Avaliados separadamente, os genótipos para o grupo caso, temos I/I (23, 5%), I/D (45, 8%) e D/D (30, 6%). Os genótipos para o grupo controle, I/I (28, 6%), I/D (46,4%) e D/D (25%). A maior prevalência observada é do genótipo I/D em ambos os grupos. Nas frequências alélicas calculadas através do Teste de Hardy-Weinberg, o alelo D mutante apresenta-se com 53% no grupo caso e 48% no grupo controle. O alelo I selvagem presente em 47% no grupo caso e 52% no grupo controle. A presente meta-análise conclui que o polimorfismo I/D do gene ECA estudado através dos genótipos I/D e D/D não estão associados ao risco de desenvolvimento da ND em indivíduos com DM2, porém, a presença do alelo D tem importante significância no risco de desenvolvimento da doença, assim como o papel protetivo do alelo I.

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Dias, Fernando Suparregui. "Polimorfismo I/D do gene ECA em pacientes com síndrome da Angústia respiratória aguda (SARA)." Pontifícia Universidade Católica do Rio Grande do Sul, 2007. http://hdl.handle.net/10923/1299.

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The aim of this study was to determine if the polymorphism I/D of the angiotensin converting enzyme (ACE) gene is associated with susceptibility for and mortality related to acute respiratory distress syndrome (ARDS) in a population of critically ill patients in South Brazil. A cross-sectional study was conducted of consecutive, critically ill patients, admitted to the General ICU in Porto Alegre, Brazil, between January, 2004 and June, 2006. Four hundred consecutive, critically ill patients were enrolled. A patient was considered having ARDS if he/she had criteria according the American-European Consensus Conference, anytime during the ICU stay. Interventions: A blood sample (5 ml) was drawn for genotyping I/D ACE gene polymorphism. The incidence of ARDS was 11. 8%. Patients with ARDS were younger than non- ARDS patients (p<0. 0001). The APACHE II score was similar in both groups, and the level of organ dysfunction determined by the SOFA score was higher in non-ARDS patients on the first day (p=0. 007), and thereafter, higher in the ARDS group (day 2 to day 7, p=0. 009; p=0. 003; p=0. 003; p=0. 001; p=0. 004; p=0. 04, respectively). We were unable to find any association between the I/D polymorphism of ACE gene and susceptibility or mortality in ARDS and non-ARDS patients. ICU and hospital mortality in ARDS patients was 42. 5% and 48. 9%, respectively.
O presente estudo tem como objetivo estudar a associação entre o polimorfismo I/D do gene ECA com a susceptibilidade e mortalidade relacionada à SARA, em uma população de pacientes críticos no sul do Brasil. Todos os pacientes críticos admitidos na UTI Geral do Hospital São Lucas da PUCRS entre janeiro de 2004 e junho de 2006 foram candidatos à pesquisa, dos quais foram arrolados 400 indivíduos. O paciente foi considerado como tendo síndrome da angústia respiratória aguda (SARA) ao preencher os critérios do Consenso Americano- Europeu em qualquer momento da internação na UTI. De cada paciente foram retirados 5mL de sangue para obtenção de DNA e genotipagem do polimorfismo I/D do gene ECA. A incidência de SARA foi de 11,8%. Os pacientes com SARA foram mais jovens do que os sem SARA (p=0,0001). O escore APACHE II da admissão foi semelhante nos grupos de pacientes com (19,3±6,85) e sem SARA (19,4±8,14), e o grau de disfunção orgânica determinado pelo escore SOFA foi maior entre os pacientes sem SARA no primeiro dia (p=0,007) e depois, durante a primeira semana, entre os pacientes com SARA (dia 2 até dia 7, p=0,009; p=0,003; p=0,003; p=0,001; p=0,004; p=0,04, respectivamente). Este estudo não encontrou nenhuma associação entre o polimorfismo I/D do gene ECA e a susceptibilidade à SARA ou à mortalidade. A mortalidade na UTI e na internação hospitalar foi de 42,5% e de 48,9%, respectivamente.

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Loewe, Axel [Verfasser], and O. [Akademischer Betreuer] Dössel. "Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves / Axel Loewe. Betreuer: O. Dössel." Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/1103574027/34.

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Gerguri, Shqipe [Verfasser]. "Clinical impact of ”pure’’ empirical catheter ablation of slow pathway in patients with non-ECG documented clinical on-off tachycardia / Shqipe Gerguri." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1183370296/34.

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Marruffo, Fernández Nataly Andrea. "Estimación de las frecuencias INDEL (I/D) del gen ECA en 4 muestras de la población peruana." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2016. https://hdl.handle.net/20.500.12672/4834.

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La Enzima Convertidora de Angiotensina (ECA) protagoniza un rol importante en la regulación de la presión arterial en dos sistemas fisiológicos: renina-angiotensina y cinina-calicreína. El gen ECA se localiza en el brazo largo del cromosoma 17 (17q23), consta de 26 exones y 25 intrones. Un polimorfismo de inserción/deleción ubicado en el intrón 16, el cual corresponde a una secuencia Alu repetitiva de ~287 pb, da origen a tres genotipos: inserción (II), inserción/deleción (I/D) y deleción (DD). Existen estudios que vinculan al alelo D con el aumento de la expresión de la ECA, y como consecuencia de ello se tendría una predisposición genética a sufrir enfermedades; sin embargo, estos estudios también han revelado que la determinación del polimorfismo I/D depende de la población muestreada, ya sea por el grupo étnico o por el lugar geográfico a donde esta población pertenece. El objetivo de este estudio es determinar la frecuencia del polimorfismo I/D del gen ECA en muestras poblacionales peruanas. Se amplificó un fragmento de ADN perteneciente al intrón 16 de este gen mediante la técnica de reacción en cadena de la polimerasa (PCR). Se trabajó con poblaciones de Monsefú, Moche, Huacho y Lima, resultando que el genotipo predominante para las tres primeras poblaciones es homicogoto II (84.2%, 66.7% y 56.8% respectivamente), en cambio para la población de Lima el genotipo predominante es el heterocigoto I/D (42.9%). El alelo I es el más frecuente en las 4 poblaciones: Monsefú (92.1%), Moche (80.3%), Huacho (73.0%) y Lima (62.5%). Las cuatro poblaciones se encuentran en equilibrio de Hardy–Weinberg. Los valores de las frecuencias génicas y genotípicas obtenidas son muy semejantes a los reportados en poblaciones latinoamericanas, donde la prevalencia del genotipo DD es muy baja y la frecuencia del alelo I es alta. Palabras clave: presión arterial, sistema fisiológico, polimorfismo (genético), inserción Alu, genotipo, predisposición genética.
--- Angiotensin converting enzyme (ACE) plays an essential role in regulating blood pressure in two physiological systems: renin-angiotensin and kinin-kallikrein. The ACE gene is located on the long arm of the chromosome 17 (17q23), consisting of 26 exons and 25 introns. An insertion/deletion polymorphism located in intron 16, which corresponds to an Alu repetitive sequence of ~ 287 bp, gives rise to three genotypes: Insertion (II), insertion / deletion (I/D) and deletion (DD). There are studies that link the D allele with increased ACE expression, and consequently there might be a genetic predisposition to disease; however, these studies have also revealed that the determination of polymorphism I/D depends on the population sampled, either by ethnicity or the geographical location of this population. The aim of this study is to determine the frequency of the polymorphism I/D of ACE gene in Peruvian population samples. A DNA fragment belonging to intron 16 of this gene was amplified by the technique of polymerase chain reaction (PCR). We worked with populations of Monsefú, Moche, Huacho and Lima, being the predominant genotype for the first three populations is homozygous II (84.2%, 66.7% and 56.8% respectively), while for the population of Lima the predominant genotype is the heterozygous I/D (42.9%). The I allele is the most common in the 4 populations: Monsefú (92.1%), Moche (80.3%), Huacho (73.0%) and Lima (62.5%). The 4 populations are in Hardy-Weinberg equilibrium. The values of gene and genotype frequencies obtained are very similar to those reported in Latin American populations, where the prevalence of DD genotype is very low and I allele frequency is high. Keywords: blood pressure, physiological system, polymorphism (genetic), Alu insertion, genotype, genetic predisposition.
Tesis

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Dias, Fernando Suparregui. "Polimorfismo I/D do gene ECA em pacientes com s?ndrome da Ang?stia respirat?ria aguda (SARA)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2008. http://tede2.pucrs.br/tede2/handle/tede/5306.

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O presente estudo tem como objetivo estudar a associa??o entre o polimorfismo I/D do gene ECA com a susceptibilidade e mortalidade relacionada ? SARA, em uma popula??o de pacientes cr?ticos no sul do Brasil. Todos os pacientes cr?ticos admitidos na UTI Geral do Hospital S?o Lucas da PUCRS entre janeiro de 2004 e junho de 2006 foram candidatos ? pesquisa, dos quais foram arrolados 400 indiv?duos. O paciente foi considerado como tendo s?ndrome da ang?stia respirat?ria aguda (SARA) ao preencher os crit?rios do Consenso Americano- Europeu em qualquer momento da interna??o na UTI. De cada paciente foram retirados 5mL de sangue para obten??o de DNA e genotipagem do polimorfismo I/D do gene ECA. A incid?ncia de SARA foi de 11,8%. Os pacientes com SARA foram mais jovens do que os sem SARA (p=0,0001). O escore APACHE II da admiss?o foi semelhante nos grupos de pacientes com (19,3?6,85) e sem SARA (19,4?8,14), e o grau de disfun??o org?nica determinado pelo escore SOFA foi maior entre os pacientes sem SARA no primeiro dia (p=0,007) e depois, durante a primeira semana, entre os pacientes com SARA (dia 2 at? dia 7, p=0,009; p=0,003; p=0,003; p=0,001; p=0,004; p=0,04, respectivamente). Este estudo n?o encontrou nenhuma associa??o entre o polimorfismo I/D do gene ECA e a susceptibilidade ? SARA ou ? mortalidade. A mortalidade na UTI e na interna??o hospitalar foi de 42,5% e de 48,9%, respectivamente.

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Brack, Eva [Verfasser], and Matthias [Akademischer Betreuer] Griese. "Einfluss von Surfactantprotein A und D auf die ECP-Degranulation von humanen eosinophilen Granulozyten / Eva Brack. Betreuer: Matthias Griese." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/104214737X/34.

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Umburanas, Rubia Caldas. "O GENE DA ENZIMA CONVERSORA DE ANGIOTENSINA E SUAS VARIANTES GENOTIPICAS EM HIPERTENSOS E NORMOTENSOS." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2013. http://tede2.uepg.br/jspui/handle/prefix/931.

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High blood pressure (HBP) is a multifactorial clinical condition characterized by high and sustained levels of blood pressure (BP). The renin-angiotensin system is involved in the control of the BP, and has as a component the angiotensin converting enzyme (ACE). Recent studies that relate gene variants of Angiotensin Converting Enzyme (ACE) gene, increase the risk of hypertension, compared with the presence of the allele D. Thus, it becomes necessary studies aimed at investigating the relationship of the polymorphism in intron 16 of the ACE gene with hypertension. The aim of the study was to verify the relationship between I / D polymorphism of the ACE gene and genotypic variants with the installation of HBP in four distinct groups. Participants were 112 individuals arranged in the following groups: normotensive (control), hypertensive and non-obese, hypertensive and obese and hypertensive and with type II diabetes mellitus. We evaluated the possible relationship between I/D polymorphism of the ACE gene in different groups of hypertensive patients, but there was no significant difference between the genotypes in different groups in the sample. Regarding the epidemiology higher the body mass index (BMI), waist circumference, triglycerides and cholesterol levels and physical inactivity, was greater incidence of hypertension in the population. The data obtained in this study reinforce environmental interference that are prevalent in the evolution of the framework of HBP and not related to the frequency of the D allele in the population studied.
A hipertensão arterial sistêmica (HAS) é uma condição clínica multifatorial caracterizada por níveis elevados e sustentados de pressão arterial (PA). O sistema renina-angiotensina está envolvido no controle da PA, e tem como um dos componentes a enzima conversora de angiotensina (ECA). Estudos recentes relacionam que variantes do gene da Enzima Conversora de Angiotensina (ECA) aumentam o risco de HAS, com relação à presença do alelo D. Com isso, se fazem necessários estudos voltados à investigação da relação do polimorfismo no íntron 16 do gene da ECA com a HAS. O objetivo do estudo foi verificar a existência de relação do polimorfismo I/D do gene da ECA e suas variantes genotípicas com a instalação da HAS, em quatro grupos distintos. Participaram da pesquisa 112 indivíduos arranjados nos seguintes grupos: normotenso (controle), hipertenso e não obeso, hipertenso e obeso, e hipertenso e com diabetes mellitus tipo II. Foi avaliada a possível relação do polimorfismo I/D do gene da ECA, em diferentes grupos de hipertensos, porém não foi encontrada diferença significativa quanto aos genótipos nos diferentes grupos na amostra analisada. Em relação à epidemiologia, quanto maior o índice de massa corporal (IMC), cintura abdominal, valores de colesterol e triglicerídeos e sedentarismo, maior foi a incidência de HAS na população. Os dados obtidos no presente estudo reforçam que interferências ambientais são prevalentes na evolução do quadro de HAS, e não relacionado à frequência do alelo D na população analisada.

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Mörsdorf, Hans-Joachim [Verfasser], and Elmar [Akademischer Betreuer] Nöth. "Detection of Sleep related Breathing Disorders and Sleep Stages from the Evaluation of ECG Signals = Erkennung von schlafbezogenen Atmungsstörungen und Schlafstadien anhand der Auswertung von EKG-Signalen / Hans-Joachim Mörsdorf. Betreuer: Elmar Nöth." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2011. http://d-nb.info/1017639329/34.

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Arejano, Gabrielle Gaspar. "Associações dos polimorfismos genéticos ECA I/D, ACTN3 R577X e PON1 C(-107)T de mulheres diabéticas e/ou hipertensas e controles." Universidade Federal de Pelotas, 2017. http://guaiaca.ufpel.edu.br:8080/handle/prefix/3946.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
OBJETIVO: Estudar as associações entre os polimorfismos genéticos ECA I/D, ACTN3 R577X e PON1 C(-107)T com diabetes e hipertensão em pacientes atendidos pelo Sistema Único de Saúde. MÉTODOS: Foram coletados dados bioquímicos dos prontuários dos pacientes crônicos de três Unidades Básicas de Saúde da Família localizadas na cidade de Rio Grande. Foram aplicados questionários de consumo alimentar, nível de atividade física e socioeconômico. Foi realizada a avaliação nutricional dos pacientes e, em seguida, a coleta de saliva para a extração do DNA genômico para análise dos polimorfismos genéticos. Os polimorfismos foram analisados por PCR simples, multiplex e por polimorfismo de tamanho de fragmento de restrição. RESULTADOS: O grupo caso obteve maiores valores de peso, IMC, circunferência da cintura, percentual de gordura, pressão arterial, colesterol total, triglicerídeos e glicemia em comparação ao grupo controle. Foram encontradas associações do genótipo XX do polimorfismo R577X da ACTN3 com valores mais elevados de glicemia e triglicerídeos. O genótipo TT do polimorfismo C(-107)T da PON1 também obteve níveis maiores de triglicerídeos comparado aos outros 2 genótipos. CONCLUSÃO: O genótipo XX da ACTN3 foi fortemente relacionado com níveis baixos de HDL e altos valores de triglicerídeos, colesterol total e glicemia. Ainda encontramos altos valores de triglicerídeos e LDL no genótipo TT e menores níveis de colesterol total ligados ao genótipo CC da PON1.
OBJECTIVE: To study associations between polymorphisms in the angiotensin converting enzyme (ACE I/D), actinin 3 (ACTN3 R577X) and paraoxonase 1 (PON1 C-(107)T with chronic diseases (diabetes and hypertension) in patients attended by Sistema Único de Saúde (SUS). METHODS: Biochemical data were collected from the charts in the Basic Health Units of the Family located in the same region of the city of Rio Grande. Charts about food consumption, physical activity level and socioeconomic were applied. Nutritional data were evaluated, genomic DNA was extracted from collected saliva samples and used for analysis of genetic polymorphism. RESULTS: The case group had higher values of weight, BMI, waist circumference, body fat percentage, blood pressure, cholesterol, triglycerides and blood glucose in comparison with control group. Associations were found of XX genotype of the polymorphism R577X ACTN3 with higher values of blood glucose, and triglycerides levels. The TT genotype of the C(-107)T PON1 also had higher levels of triglycerides compared to other 2 genotypes. CONCLUSION: The genotype XX of ACTN3 was strong related with low HDL levels and high triglycerides, total cholesterol and glucose levels. Still, we realized high triglycerides and LDL leves in TT genotype of PON1 and lower leves of total cholesterol linked to CC genotype of PON1.

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Albuquerque, Neto Severino Leão de. "Associação dos polimorfismos I/D do gene da ECA e R557X do gene da ACTN3 aos indicadores de desempenho em jovens atletas da natação brasileira." Universidade Católica de Brasília, 2018. https://bdtd.ucb.br:8443/jspui/handle/tede/2442.

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The search for better sports performance has encouraged studies on the interaction between environmental and genetic factors. In this perspective, while environmental factors stimulate morphofunctional adaptations, genetic polymorphisms modulate the genes responsible for these adaptations. Therefore, the identification of the candidate genes and their respective polymorphisms with potential to influence the phenotypes related to this performance have been the target of the researchers of the area. Among the promising polymorphisms are the I/D of the angiotensin converting enzyme (ACE) gene and the α-actinin-3 (ACTN3) gene R577X. In the field of sports genetics, swimming has been studied, but research on the younger athletes is rare. The objective of this study was to analyze the association between ACE and ACTN3 polymorphisms in sports performance indicators in 120 brazilian swimmers (75 Boys and 45 Girls), aged 15 to 17 years (16.76 ± 0.6 years ), affiliated to the Brazilian Confederation of Aquatic Sports. 102 non-athletes of the same age group (16.51 ± 0.95 years) residing in the Federal District were part of the control group (56 Boys and 46 Girls). These were subdivided by official swimming tests (short: ≤200m vs long: ≥400m), related to the phenotypes of sports performance (strength vs. power) and by the competitive level (elite vs. sub-elite). The elite status (international experiences) and the technical index (TI) were adopted as indicators of performance. It was also evaluated the total genothype score (TGS) associated to the strength / power phenotypes. The technique of scraping buccal mucosa epithelial cells with the aid of a specific swab was used to collect the samples. In the athletes was collected during the XXIV Brazilian Junior Swimming Championship and among the students, in the intervals of the Physical Education classes. The genotyping of the polymorphisms was performed through the polymerase chain reaction technique obeying standardized and scientifically validated protocols. All the volunteers signed the agreement with prior consent of those responsible. Chi-square and Mann-Whitney tests were used when the variables were not normally distributed. Pearson's correlation and t-test for independent samples were used for the parametric data. The groups (athletes and non-athletes) demonstrated Hardy-Weinberg equilibrium for the genotypic and allelic distribution of polymorphisms. Sub-elite athletes (≤200m and ≥ 400m) presented allelic and genotype frequencies in both polymorphisms very close to those observed for the control group. The elite group of athletes was formed by specialists in short competitions (≤200m). Significant primacy of the DD genotype of ACE was observed for elite athletes. The D allele and DD genotype were also predominant among athletes of the same phenotypic (strength/power) group identified in the upper quartile (Q3) of TI, with significant differences especially in favor of elite athletes. Analysis of the ACTN3 polymorphism revealed that the R allele was predominant in all groups, except for the elite group, which had a frequency of the heterozygote RX genotype significantly higher. The best TI’s were verified among the athletes (≤200m) genotyped for RX and RR, with supremacy for the homozygote among elite athletes. In the joint evaluation of the two polymorphisms, the elite group presented significant genotypic supremacy of DD + RX addition compared to the other groups that presented higher occurrence of DD + RR homozygotes. The TGS analysis showed that athletes with better genotype profiles (score ≥75) also had the best TI’s. The results of the study suggest that the elite status and the best TI’s verified among juvenile athletes were influenced positively by the genotype associations typically expected.
A busca pelo melhor desempenho esportivo tem incentivado estudos sobre a interação entre os fatores ambientais e genéticos. Nesta perspectiva, enquanto os fatores ambientais estimulam as adaptações morfofuncionais os polimorfismos genéticos modulam os genes responsáveis por estas adaptações. Por isso, a identificação dos genes candidatos e seus respectivos polimorfismos com potencial de influenciar os fenótipos relacionados a este desempenho têm sido alvo dos pesquisadores da área. Dentre os polimorfismos promissores destacam-se o I/D do gene da enzima conversora da angiotensina (ECA) e o R577X do gene da α-actinina-3 (ACTN3). Na área da genética do esporte a natação tem sido estudada, mas são raras as pesquisas dedicadas aos atletas mais jovens, notadamente na população brasileira. O objetivo do estudo foi analisar a associação entre os polimorfismos da ECA e da ACTN3 aos indicadores de desempenho esportivo em 120 atletas da natação brasileira (75 Rapazes e 45 Moças), na faixa etária dos 15 aos 17 anos (16,76 ± 0,6 anos), filiados à Confederação Brasileira de Desportos Aquáticos (6,46 ± 2,13 anos). 102 jovens escolares (56 Rapazes e 46 Moças) não-atletas da mesma faixa etária (16,51 ± 0,95 anos) residentes no Distrito Federal fizeram parte do grupo controle. Estes foram subdivididos pelas provas oficiais da natação (curtas: ≤200m vs longas: ≥400m), relacionadas tipicamente aos fenótipos opostos do desempenho atlético (respectivamente: força/potência vs resistência) e pelo nível competitivo (elite vs sub-elite). O status de elite (experiências internacionais) e o índice técnico (IT) foram adotados como indicadores de desempenho. Foi avaliado também o score total dos genótipos (TGS) associados aos fenótipos da força/potência. O material genético dos atletas foi coletado durante o XXIV Campeonato Brasileiro Juvenil de Natação e entre os escolares, nos intervalos das aulas de Educação Física. A técnica de raspagem das células epiteliais da mucosa bucal com o auxílio de swab específico foi utilizada para a coleta das amostras. A genotipagem dos polimorfismos foi realizada através da técnica de reação em cadeia da polimerase obedecendo protocolos padronizados e cientificamente validados. Todos os voluntários assinaram o termo de assentimento com prévia anuência dos responsáveis. Os testes do Qui-Quadrado e Mann-Whitney foram utilizados quando as variáveis não apresentavam distribuição normal. A correlação de Pearson e o teste t para amostras independentes foram utilizados para os dados paramétricos. Os grupos (atletas e não-atletas) demonstraram equilíbrio Hardy-Weinberg para a distribuição genotípica e alélica dos polimorfismos. Os atletas sub-elite (≤200m e ≥400m) apresentaram frequências alélicas e genotípicas em ambos os polimorfismos muito próximas às verificadas para o grupo controle. O grupo de atletas de elite foi formado por especialistas em provas curtas (≤200m). Observou-se supremacia significativa do genótipo DD da ECA para os atletas de elite. O alelo D e o genótipo DD foram predominantes também entre os atletas do mesmo grupo fenotípico (força/potência) identificados no quartil superior (Q3) do IT, com diferenças significativas especialmente em prol dos atletas de elite. A análise do polimorfismo da ACTN3 revelou que o alelo R foi predominante em todos os grupos, exceto para o grupo de elite, os quais apresentaram frequência do genótipo heterozigoto RX significativamente superior. Os melhores IT foram verificados entre os atletas (≤200m) genotipados para RX e RR, com supremacia para o homozigoto entre os atletas de elite. Na avaliação conjunta dos dois polimorfismos o grupo de elite apresentou significativa supremacia genotípica da adição DD+RX frente aos demais grupos que apresentaram maior ocorrência dos homozigotos DD+RR. A análise do TGS demonstrou que os atletas com melhores perfis genofenotípicos (score ≥75) apresentaram também os melhores IT. Os resultados do estudo sugerem que o status de elite e os melhores IT verificados entre atletas juvenis sofreram influência positiva das associações genofenotípicas tipicamente esperada.

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29

Pedroso, José Alberto Rodrigues. "Evolução temporal da função renal entre pacientes criticamente doentes: papel dos polimorfismos I/D e -262A>T do gene da enzima conversora de angiotensina (ECA)." Pontifícia Universidade Católica do Rio Grande do Sul, 2006. http://hdl.handle.net/10923/1274.

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A disfunção de múltplos órgãos e a Insuficiência renal aguda compartilham muitos dos fatores fisiopatológicos envolvidos na sua instalação. Estudos recentes correlacionam a herança genética com a suscetibilidade à disfunção de orgãos entre pacientes criticamente doentes. Muitos consideram que o gene da ECA poderia ser um potencial candidato a fator de risco genetico em pacientes de UTI. Em nosso estudo, examinamos os efeitos dos polimorfismos I/D e -262A>T do gene da ECA na função renal em pacientes criticamente doentes de uma UTI do sul do Brasil. Um escore de disfunção multiorgânico mundialmente reconhecido, o SOFA (avaliação seqüencial da disfunção do órgão), foi empregado para determinar o estado basal da saúde no primeiro dia de admissão à UTI. Considerando o escore SOFA da admissão e a tendência da função renal (através do escore diário do SOFA renal, determinado pela medida diária da creatinina sérica e da diurese), nós consideramos a hipótese de que os polimorfismos I/D e -262A>T do gene ECA poderiam influenciar na tendência da função renal em pacientes de ICU. Um total de 153 pacientes adultos, criticamente doentes (79 homens e 77 mulheres), foi incluído neste estudo.Nós monitoramos os pacientes diariamente durante sua permanência na UTI e hospitalar (período máximo de observação de 224 dias). Foi observada a progressão à disfunção renal (valores 3 e 4 de escores SOFA) nos primeiros sete dias da internação em UTI e a necessidade de diálise durante este período. As freqüências genotípicas totais em nossa amostra foram II=0. 17; ID=0. 46; DD=0. 37 e AA=0. 30; AT=0. 55; TT=0. 15, e as freqüências alélica foram I=0. 40; D=0. 60 e A=0. 56; T=0. 44. Este é o primeiro estudo delineado para verificar a influência de polimorfismos I/D e -262A>T do gene ECA na disfunção renal aguda entre pacientes de UTI. Nenhuma associação significativa foi encontrada entre a evolução da função renal durante a primeira semana de internação na UTI e os genótipos ou freqüências alélicas dos polimomrfismos em questão. Os polimorfismos I/D e -262A>T não apresentaram nenhum impacto significativo na tendência da função renal durante a primeira semana de internação na UTI, igualmente, não houve influência da herança genética sobre a mortalidade nos pacientes criticamente doentes estudados.

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30

Tomás, Rivera Walter Rayf. "Aplicación del aditivo Eco Road 2000 en la estabilización de suelos cohsivos en la pavimentación d elas vías de anexo de Palian en la provincia de Huancayo." Bachelor's thesis, Universidad Continental, 2017. http://repositorio.continental.edu.pe/handle/continental/3372.

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Objetivos: la presente tesis tiene como objetivo demostrar, mediante diversos estudios, si lo mencionado en la especificación técnica del producto elegido cumple con la dosificación de 1 litro por 15 m3; conocer en qué porcentaje aumenta la resistencia del suelo (CBR), ya sea en condiciones óptimas o críticas; y, por último, realizar una evaluación presupuestal. Método: para realizar los diversos estudios acudimos a las Normas Técnicas Peruanas del Ministerio de Transportes y Comunicaciones (MTC) y de la American Society for Testing Materials (ASTM), dispusimos de un laboratorio que contaba con los equipos necesarios para realizar los ensayos de suelos y utilizamos un determinado software para elaboración del presupuesto (S10 2005). Resultados: se obtuvieron siete calicatas con más del 40% de CBR, cumpliendo estas los estándares para erigirse como material de subbase; así también, tres calicatas con CBR de 38.55%, 36.10% y 21.70%, siendo las dos primeras de una subrasante extraordinaria (CBR >30%) y la tercera de una muy buena (CBR entre 20% y 30%). Conclusiones: se concluye que la aplicación del aditivo conlleva menores costos que su omisión, reduciendo el gasto en S/ 14.42 respecto al pavimento flexible y en S/ 92.02 respecto al rígido. Es, por lo tanto, rentable el uso del aditivo Eco Road 2000.
Tesis

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31

Pedroso, Jos? Alberto Rodrigues. "Evolu??o temporal da fun??o renal entre pacientes criticamente doentes : papel dos polimorfismos I/D e -262A>T do gene da enzima conversora de angiotensina (ECA)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2006. http://tede2.pucrs.br/tede2/handle/tede/5522.

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A disfun??o de m?ltplos ?rg?os e a Insufici?ncia renal aguda compartilham muitos dos fatores fisiopatol?gicos envolvidos na sua instala??o. Estudos recentes correlacionam a heran?a gen?tica com a suscetibilidade ? disfun??o de org?os entre pacientes criticamente doentes. Muitos consideram que o gene da ECA poderia ser um potencial candidato a fator de risco genetico em pacientes de UTI. Em nosso estudo, examinamos os efeitos dos polimorfismos I/D e -262A>T do gene da ECA na fun??o renal em pacientes criticamente doentes de uma UTI do sul do Brasil. Um escore de disfun??o multiorg?nico mundialmente reconhecido, o SOFA (avalia??o seq?encial da disfun??o do ?rg?o), foi empregado para determinar o estado basal da sa?de no primeiro dia de admiss?o ? UTI. Considerando o escore SOFA da admiss?o e a tend?ncia da fun??o renal (atrav?s do escore di?rio do SOFA renal, determinado pela medida di?ria da creatinina s?rica e da diurese), n?s consideramos a hip?tese de que os polimorfismos I/D e -262A>T do gene ECA poderiam influenciar na tend?ncia da fun??o renal em pacientes de ICU. Um total de 153 pacientes adultos, criticamente doentes (79 homens e 77 mulheres), foi inclu?do neste estudo. N?s monitoramos os pacientes diariamente durante sua perman?ncia na UTI e hospitalar (per?odo m?ximo de observa??o de 224 dias). Foi observada a progress?o ? disfun??o renal (valores 3 e 4 de escores SOFA) nos primeiros sete dias da interna??o em UTI e a necessidade de di?lise durante este per?odo. As freq??ncias genot?picas totais em nossa amostra foram II=0.17; ID=0.46; DD=0.37 e AA=0.30; AT=0.55; TT=0.15, e as freq??ncias al?lica foram I=0.40; D=0.60 e A=0.56; T=0.44. Este ? o primeiro estudo delineado para verificar a influ?ncia de polimorfismos I/D e -262A>T do gene ECA na disfun??o renal aguda entre pacientes de UTI. Nenhuma associa??o significativa foi encontrada entre a evolu??o da fun??o renal durante a primeira semana de interna??o na UTI e os gen?tipos ou freq??ncias al?licas dos polimomrfismos em quest?o. Os polimorfismos I/D e -262A>T n?o apresentaram nenhum impacto significativo na tend?ncia da fun??o renal durante a primeira semana de interna??o na UTI, igualmente, n?o houve influ?ncia da heran?a gen?tica sobre a mortalidade nos pacientes criticamente doentes estudados

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32

Walter, Jason. "Economics of innovation: competition, clubs and the environment." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/19009.

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Doctor of Philosophy
Department of Economics
Yang-Ming Chang
Innovation is development of new ideas that leads to better solutions to current problems. From an economic standpoint, innovation is the engine of economic growth. The appearance of innovation is not uniform in the market, and neither are its affects. The development of new products and technology is significant in any industry. As a result, understanding the path of progress within an industry is necessary to maximize the benefit from innovation. The focus of this research is to further understand the relationship between producers, consumers, and the environment, in the context of innovation. Three scenarios are evaluated. First, innovation evaluated in the context technology intensive industries with product differentiation. Using an optimal control approach with product differentiation and firm outlook we examine conditions that maximize social welfare. When firm(s) have the same discount rate regardless of market structure, a monopoly will develop more innovative products. However, it is shown that competition may increase innovation if firms alter their outlook in a duopoly market structure. Next, influence of consumers on producer adoption of clean technology is evaluated. A spatial model is developed to analyze welfare implications of environmental policies in a competitive market with production and consumption heterogeneity. Consumers with heterogeneous preferences choose between non-green and certified green products, while firms with heterogeneous production costs decide whether to engage in green production. In order for green products to be recognized by consumers, firms must join a green club. The number of green firms, environmental standard, and overall welfare under the market solution are all found to be socially sub-optimal. Finally, producer innovation in markets characterized by public policy due to emission concerns is evaluated. Using a dynamic approach, we derive a firm’s optimal R&D investment strategy to develop clean technology. Explicitly allowing for the cumulative nature of R&D shows that emissions per unit of output are lowest when the firms cooperate in R&D, and show that a profit-maximizing merged entity will never choose the most efficient investment strategy in clean technology, which has implications for emission tax policy and environmental innovation to improve overall welfare.

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33

Netto, Zair Candido de Oliveira. "Estudo molecular dos genes alfa actinina 3 e ECA I/D em atletas de esportes de combate, artes marciais e lutas de alto rendimento: ênfase em luta de percussão." Universidade Tecnológica Federal do Paraná, 2014. http://repositorio.utfpr.edu.br/jspui/handle/1/1020.

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Os fatores genéticos e o meio ambiente são pontos relevantes no que tange a capacidade física do ser humano. O objetivo deste estudo foi avaliar o genótipo dos genes, ACTN3 e da ACE I/D, em lutadores de alto rendimento na modalidade de percussão. Neste estudo fizeram parte do conjunto amostral 15 atletas de alto rendimento da esportes de combate e arte marcial, sendo sendo 6 lutadores de Karatê, 4 lutadores de Taekwondo, 4 lutadores de Muay Thai e 1 lutador de Boxe, todos do sexo masculino com idade média de 25,06 anos, com experiência nacional e internacional em suas respectivas modalidades e categorias de peso. A genotipagem dos polimorfismos do ACTN3 e ACE I/D foi realizada por reação em cadeia da polimerase (PCR) a partir do DNA genômico. As frequências genotípicas e alélicas foram comparadas com populações controle e de atletas pelos testes do Qui-Quadrado, e exato de Fisher, para todas as análises foi adotado p˂0,05. Os resultados obtidos para as frequências genotípicas e alélicas do ACTN3 (RR=35,71%,RX=57,14% e XX=7,14%; R=64,28% e X=33,71%) e do ACE I/D (DD=30,76%, ID=50,84% e II=15,36%; D=65,2% e I=34,8%) não diferiram significativamente da população controle e com estudos relacionados a força. Em conclusão os dados da presente pesquisa seguem os padrões esperados para população no que tange a frequência genotípicas e em sua distribuição alélica nos genes da ACTN3 e da ACE I/D com lutadores de percussão.
Genetic factors and the environment are relevant points regarding the physical capacity of the human being. The objective of this study was to evaluate the genotype of genes, ACTN3 and ACE I / D with fighters in high yield in the form of percussion. In this study were part of the sample set of 15 high-level athletes in combat sports and martial arts, 6 fighters from Karate, 4 fighters Taekwondo, 4 fighters Muay Thai and 1 boxing. All fighters being present, all males with average age of 25.06 years with national and international experience in their respective weight classes and methods. Genotyping of polymorphisms of ACTN3 and ACE I / D was performed by polymerase chain reaction (PCR) chain from the genomic DNA. The genotypic and allelic frequencies were compared with control populations and athletes by Qui-Quadrado and Fisher exact tests for all analyzes was adopted P=0.05. The results obtained for genotypic and allelic frequencies of ACTN3 (RR = 35.71%, 57.14% and RX = XX = 7.14%; R = X = 64.28% and 33.71%) and ACE I / D (DD = 30.76%, 50.84% and ID = II = 15.36%; D = I = 65.2% and 34.8%) did not differ significantly from the control population e power sports In conclusion the data of this study follow the expected population in relation to genotypic and allelic frequency distribution in the ACTN3 gene and ACE I / D fighters of percussion.

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34

Almeida, Jeeser Alves de. "Consumo m??ximo de oxig??nio, validade de equa????es de predi????o e poss??vel influ??ncia do polimorfismo I/D do gene da ECA sobre sua determina????o." Universidade Cat??lica de Bras??lia, 2011. https://bdtd.ucb.br:8443/jspui/handle/tede/2194.

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Predictive equations have been widely used to determine indirect maximal oxygen uptake (VO2max) as it can evaluate a large number of people with low cost and, in most cases, nearing the specificity of some sports. However, the VO2max can be influenced by various environmental and genetic factors, the validity of these equations on estimating VO2max of young brazilians should be further studied. This investigation includes two studies with young physically active brazilians. The first one evaluated the validity of a predictive equation proposed by Cureton et al., (1995) in estimating VO2max from the 1600m running performance, and also to suggest a new and specific predictive equation for physically active brazilians. . The second study examined the possible influence of I/D polymorphism of ACE genotype on determining the real and predicted VO2max in these participants. For the study I thirty young and physically active underwent both to a 1600m running test and an incremental cardiopulmonary exercise test (IT) on a treadmill with analysis of expired gases. The participants were divided into two groups (G1 and G2) being that in G1 the new equation was generated (Simples linear regretion between mean velocity at 1600m and VO2max) while its validity was examined in G2. When applied on the results of G2, a One Way ANOVA showed no statistical difference and a high correlation between VO2max obtained by the predictive equation generated in G1 [VO2max = (0.177 * 1600Vm) + 8.101] with the values of IT (50.1 ??7.2 mL.kg-1.min-1 vs 50.1 ??7.1 mL.kg-1.min-1) (P>0.05) (R = 0.81). However the VO2max results determined from equation of Cureton et al., (1995) [VO2peak = -8.41 (MRW) +0.34 (MRW) 2 + 0.21 (Age x Gender) ??? 0.84 (BMI) + 108.94] (44.2?? 6.5mL.kg-1.min-1) differed from both IT and the values obtained from the new proposed equation (P<0.05). The concordance between methods was confirmed by Bland and Altman technique. For the study 2, 57 participants underwent the same procedures as study 1, but had their DNA extracted and were genotyped for the insertion/deletion (I/D) polymorphism of the ACE gene. The participants were separated into three groups accordingly to the I/D polymorphism of ACE gene (being allocated either in DD, ID, or II group). The results revealed significantly lower 1600m velocity as well as VO2max for DD carriers compared to II and ID individuals (45.6 ??1.81 mL.kg-1.min-1 vs 51.9 ?? 0.79 mL.kg-1.min-1 vs 54.4 ?? 0.96 mL.kg-1.min-1) (P <0.01). On the other hand, a within-group analysis revealed that VO2max obtained in IT did not differ from that calculated by the equation generated in Study I. Moreover, the equation generated in Study I was considered valid for estimating the VO2max in physically active young adults through a 1600m running test despite of being II, ID or DD carrier. Although the influence of I/D polymorphism of ACE gene on VO2max and middle distance performance , the accuracy of the proposed equation on predicting VO2max did not suffer interference from the I/D polymorphism of the ACE gene.
Equa????es de predi????o t??m sido amplamente utilizadas na determina????o indireta do consumo m??ximo de oxig??nio (VO2max), pois podem avaliar um grande n??mero de pessoas com baixo custo e, na maioria das vezes, chegando pr??ximo ?? especificidade de algumas modalidades esportivas. Contudo, sabendo-se que o VO2max pode ser influenciado por diversos fatores ambientais e gen??ticos, a validade destas equa????es em estimar o VO2max de brasileiros jovens deve ser melhor estudada. A presente disserta????o integra dois estudos realizados com jovens estudantes fisicamente ativos. O objetivo do primeiro estudo foi analisar a validade da equa????o proposta por Cureton et al. (1995) em estimar o VO2max dos participantes a partir do teste de corrida de 1600m, al??m de sugerir e verificar a validade de uma nova equa????o de predi????o espec??fica para brasileiros fisicamente ativos, a partir do desempenho no mesmo teste. O segundo estudo examinou a poss??vel influ??ncia do polimorfismo I/D do gene da enzima conversora de angiotensina (ECA) sobre a determina????o direta e indireta do VO2max nestes participantes. Foram recrutados, para o estudo I, trinta homens jovens e fisicamente ativos que realizaram um teste de corrida de 1600m e um teste incremental (TI) ergoespirom??trico em esteira com an??lise de gases expirados para determina????o direta do VO2max. Os participantes foram divididos em dois grupos (G1 e G2), sendo que no G1 a nova equa????o foi gerada (Regress??o linear simples entre VO2max e velocidade m??dia em 1600m 1600Vm) enquanto que a validade foi analisada no G2. Quando aplicada nos resultados do G2, ANOVA One Way revelou n??o haver diferen??a estat??stica entre o VO2max obtido pela equa????o de predi????o gerada no G1 [VO2max=(0,177*1600Vm) +8,101] com os valores do TI (50,1+7,2 mL.kg-1.min-1 vs 50,1+7,1 mL.kg-1.min-1), apresentando alta correla????o entre si (r=0,81). Entretanto, a equa????o de Cureton et al (1995) [VO2peak = -8,41(MRW) + 0,34 (MRW) 2 + 0,21 (Age x Gender) -0,84 (BMI) + 108,94] (44,2+6,5 mL.kg-1.min-1) mostrou-se diferente do TI bem como dos valores obtidos com a nova equa????o proposta (P<0,05). A an??lise de concord??ncia entre os m??todos foi analisada pela t??cnica de Bland & Altman. A partir desta nova equa????o, 57 participantes integraram o Estudo II e realizaram os mesmos procedimentos metodol??gicos, contudo tiveram seu DNA extra??do e foram genotipados para o polimorfismo I/D do gene da ECA. Assim, os participantes foram separados em tr??s grupos diferentes, de acordo com os gen??tipos do gene da ECA (DD ID II). Os resultados revelaram valores significativamente mais baixos de VO2max para indiv??duos DD quando comparados com os indiv??duos ID e II (45,6 +1,81 mL.kg-1.min-1) (51,9 +0,79 mL.kg-1.min-1) e54,4+0,96 mL.kg-1.min-1) respectivamente (P<0,01). Quando comparados o VO2max obtido no TI e o estimado pela equa????o gerada no Estudo I, para cada grupo espec??fico, n??o foram observadas diferen??as estat??sticas intra-grupos. Portanto, a equa????o que foi gerada no Estudo I foi considerada v??lida para estimar o VO2max de indiv??duos jovens fisicamente ativos atrav??s do teste de corrida em 1600m. Apesar do polimorfismo I/D do gene da ECA poder influenciar os valores de VO2max bem como o desempenho em provas de m??dia dist??ncia (1600m), a precis??o da equa????o proposta para predi????o do VO2max n??o sofreu interfer??ncia do polimorfismo I/D do gene da ECA.

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Kasbari, Abed-Elhak. "Conception et caractérisation de circuits synchrones en logiques ECL pour les communications à 40 Gbits/s." Cergy-Pontoise, 2003. http://www.theses.fr/2003CERG0179.

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Cette thèse est une contribution aux méthodes de conception et de caractérisation des circuits à très haut débit destinés aux télécommunications sur fibres optiques. Une méthode de conception des blocs élémentaires de la logique ECL est développée, et de nouveaux outils de conception sont mis au point pour réduire les temps de commutation. L'environnement de mesure a été amélioré pour permettre la caractérisation de circuits à 40 Gbit/s. Des circuits ont été conçus et fabriqués pour valider cette méthode. Deux technologies de transistors bipolaires à hétérojonction, SiGe et InP, ont été utilisées pour ces réalisations. Cette étude a conduit à d'excellents résultats. Les principaux résultats sont ceux de circuits de bascules D fonctionnant à plus de 40 Gbit/s et de démultiplexeurs à 40 Gbit/s. La caractérisation de ces circuits à plus haut débit a été limitée par le banc de mesures
This work is our contribution to the design and characterisation methods for very high speed integrated circuits. These circuits are essential to the long haul optical fiber communication systems. We present some specific design problems of high speed circuits. A design method for the emitter coupled logic (ECL) elementary blocks is developed. Furthermore, new CAD tools are introduced to minimise the switching times. The measurement setup has been improved to allow circuits characterisation at 40 Gbit/s. Integrated circuits have been designed and fabricated to validate this methods. Two different heterojunction bipolar transistor technologies have been used: a production-level SiGe technology and a high frequency performances InP technology. This work led to excellent experimental results. DFF circuits show full-rate clock operation beyond 40 Gbit/s and demultiplexers achieve 40 Gbit/s. Characterisation at a higher bit rate has been limited by the measurement setup

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Bertolo, Ana Letícia Ferreira. "Alteração da composição dos polissacarídeos da parede celular de Nicotiana tabacum, pela modulação da expressão do gene uxs que codifica a enzima UDP-D-glucuronato descarboxilase (EC 4.1.1.35)." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-04042007-142713/.

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A parede celular vegetal, estrutura essencial para as plantas, é extremamente importante para a economia humana, já que apresenta diversas utilidades, como por exemplo, fabricação de papel, fibras de vestuário, construção civil, entre outras. A maior parte da parede celular vegetal primária (aproximadamente 90%), é formada por polissacarídeos como celulose, hemiceluloses e pectinas. Os monossacarídeos, unidades formadoras dos polissacarídeos, são sintetizados, nas plantas, a partir de diferentes açúcares nucleotídeos, sendo que, o suprimento desses, pode afetar a biossíntese dos polissacarídeos da parede celular. Visando analisar o impacto da alteração do fluxo metabólico do carbono na composição da parede celular, o presente projeto de pesquisa teve como objetivo alterar a composição dos polissacarídeos da parede celular de Nicotiana tabcum, através da modulação da expressão do gene uxs, responsável pela codificação da enzima UDP-D-glucuronato descarboxilase (UDPGlcADC, EC 4.1.1.35) que converte UDP-D-glucuronato em UDP-D-xilose, importante açúcar nucleotídeo, precursor do monossacarídeo xilose. Para isso, após a clonagem do gene uxs de ervilha, foram obtidas plantas transgênicas de tabaco superexpressando esse gene. Diversas análises foram realizadas para determinação da composição química da parede celular primária e secundária dessas plantas. Pela análise de FTIR da parede celular primária, verificou-se que três linhagens transgênicas apresentaram espectrotipos consistentes, indicando uma redução na quantidade de pectinas e ligações ésteres carboxílica nessas linhagens transgênicas. Apesar de não terem sido detectadas alterações na proporção dos monossacarídeos ramnose, xilose, arabinose, manose e galactose, e na quantidade de celulose, na parede celular primária das plantas transgênicas, foram observadas diferenças na proporção de galactose não esterificada, nas linhagens que apresentaram espectrotipo. Com relação à parede celular secundária, observou-se que algumas linhagens transgênicas apresentaram maior concentração de lignina solúvel relacionada a uma redução no conteúdo de lignina insolúvel.
The plant cell wall is not only an essential structure for plants, but also an extremely important raw material in human economy. The plant cell wall has diverse utilities, for example, papermaking, textile fiber, civil construction. Polysaccharides, such as cellulose, hemicelluloses and pectins, are the major components of the primary plant cell wall (approximately 90%). These polysaccharides are formed by monosaccharides, which are synthesized in the plant from different nucleotide sugars. The suppliment of the nucleotide sugars can affect plant cell wall polysaccharides biosynthesis. Aiming at analyzing the impact of the alteration in the metabolic carbon flux on cell wall composition, the objective of this research project was to alterate the plant cell wall polysaccharides composition by the modulation of the uxs gene. This gene encodes the UDP-D-glucuronic acid decarboxylase enzyme (UDPGlcADC, EC 4.1.1.35) that promotes the conversion of UDP-D-glucuronic acid to UDP-D-xylose, an important sugar nucleotide precursor of xylose monosaccharide. To achieve this goal, the pea uxs gene was cloned and transgenic tobacco plants overexpressing this gene were obtained. Several analyses were performed to determinate the primary and secondary cell wall composition of those transgenic plants. The primary cell wall analysis by FTIR identified three transgenic lines that show different spectrotypes compared to wild type and those transgenic spectrotypes had the same features. The results indicate a reduction of pectin and ester carbonyl binding in the transgenic plants. No alterations were detected in the monosaccharide (rhamnose, xylose, arabinose, manose and galactose) proportions and the amount of cellulose in the primary cell wall of the transgenic plants. Nevertheless, differences in the proportion of unesterified galactose were observed in the same transgenic lines that showed spectrotypes. With regard to secondary cell wall, some transgenic lines showed an increase in soluble lignin which is related to a reduction in insoluble lignin.

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37

Manrique-Castaño, Daniel [Verfasser], Dirk Matthias [Gutachter] Hermann, Patrik [Gutachter] Krieger, and Tracy D. [Gutachter] Farr. "Influence of the extracellular matrix protein Tenascin-C in the immune response, glial scar formation and ECM reorganization following cerebral ischemia in mice / Daniel Manrique-Castaño ; Gutachter: Dirk Matthias Hermann, Patrik Krieger, Tracy D. Farr ; International Graduate School of Neuroscience." Bochum : Ruhr-Universität Bochum, 2020. http://d-nb.info/1223176096/34.

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38

Bonaldi, Elisa. "Strategy and Method for the Elaboration, Development and Optimization of an Innovative Recycling Process." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0167/document.

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Les réglementations sur le recyclage des produits, mais aussi le développement de l‘écoconception, obligent les industriels à rechercher des solutions de recyclage pour leurs produits en fin de vie. Les préoccupations environnementales croissantes dans l’industrie créent de nouvelles opportunités d’affaires et nécessitent des changements d’organisation pour accompagner la transition vers des activités industrielles plus durables. Une activité industrielle de recyclage de matières issues de la fin de vie d’un produit, se déroule idéalement avec la participation de différents partenaires industriels dans le cadre d’un projet collaboratif. Cela permet de développer une nouvelle supply chain de recyclage et de concevoir un nouveau produit, fabriqué grâce à cette supply chain. Les projets collaboratifs de R&D permettent de rassembler des compétences complémentaires dans le but de proposer des solutions pour accroitre le taux de recyclage d’une matière dans le domaine considéré. Aujourd’hui, les expériences de projets collaboratifs existent créant de nouvelles opportunités de marché dans l’industrie du recyclage. Cependant, nous observons qu’il n’existe pas de méthode opérationnelle permettant de guider les industriels dans la définition d’un projet collaboratif de recyclage. De plus, la sélection des partenaires pour de tels projets est une réelle difficulté pour les industriels. En effet, les valeurs apportées par les partenaires créent l’intérêt du projet et favorise le succès de la collaboration. Cependant, nous constatons qu’il n’existe pas de méthode dans le cadre du recyclage industriel pour faire un choix efficace de partenaires de R&D sur un projet collaboratif. Une revue de la littérature est présentée, pour connaitre l’état de l’art industriel et scientifique, avec un éclairage sur les meilleures pratiques existantes de façon à les prendre en compte et les intégrer, afin de proposer une contribution originale. A partir de cette revue de l’état de l’art, nous mettons en évidence un manque de méthode associant les organisations de projets collaboratifs R&D et le développement de supply chain de recyclage ; cela contribue à donner une posture originale à notre recherche. Notre contribution est de proposer une combinaison de méthodes pour accompagner les industriels dans la définition d’un projet collaboratif pour la mise en place d’une activité de recyclage. • La première méthode facilite la compréhension des mécanismes d’une industrie émergeante du recyclage, agissant simultanément sur l’impact environnemental, en recyclant les produits en fin de vie, et sur la compétitivité d’une entreprise, par sa différenciation vers de nouvelles activités industrielles. • La deuxième méthode développée est une aide pour le chef de projet R&D lors de la définition d’un « projet collaboratif de recyclage », avec la spécification du marché, du produit recyclé et de la structure projetée de la filière de recyclage. • Nous développons également la question de la sélection des partenaires d’un projet collaboratif de R&D dans le domaine du recyclage, en proposant une méthode d’évaluation ainsi que la définition de critères adaptés à ce nouveau contexte. Sur ce point, nous utilisons les techniques d’aide à la décision multicritères que nous combinons, afin d’aider les industriels dans ce processus de sélection. Une étude de cas est développée concernant l’industrie française du recyclage textile, ainsi qu’un projet de R&D collaboratif impliquant l’utilisation de matières premières recyclables provenant des véhicules hors d’usage et de vêtements fin de vie, pour l’éco-conception d’un produit nouveau. L’application de la combinaison des méthodes proposées, conduites dans le cadre d’un projet de recyclage spécifique, permet de discuter les premiers résultats et d’ouvrir ce sujet sur des perspectives de recherche à venir
Regulations on product recycling rates, but also growing consciousness on the importance of eco-design, enforce industrials to seek for solutions to recycle their products at their end of life. Growing environmental concerns in the industry allow new business opportunities and require organizational changes to support transition toward more sustainable industrial activities. Building a recycling industrial activity for materials coming from end of life products is a great challenge that requires an analysis of the opportunities and threats and the added value of industrial partners, in the scope of a collaborative project (or a collaborative network). This kind of projects aims at designing a new recycling supply chain and to design a new product that will be manufactured by this supply chain. R&D collaborative projects enable to gather complementary competencies in order to propose solutions to increase the recycling rate on the territory. Nowadays, experiences such as collaborative projects are witnessed, giving various new business possibilities in the recycling industry. However, a literature review we have performed points out that there is no existing method permitting to analyze the opportunity of a recycling value chain and to guide industrials in the definition of a “recycling collaborative project”. Moreover, for such projects, the selection of the partners is of great issue for the industrials. Indeed, the values brought by the partners make the interest of the project and favor the success of the collaboration. However, there is no existing method to choose R&D collaborative project partners efficiently in the scope of the recycling industry. A literature review presents the industrial and scientific state of the art and highlights the existing best practices in order to take them into account for the proposal of an original contribution. From the state of the art we can highlight a lack of methods that would associate R&D collaborative project organizations with the development of recycling supply chains; this positioning contributes to the originality of the work realized. Our contribution is to propose three methods to help industrials to define a collaborative project for the design and building of a new recycling supply chain: • The first method we propose facilitates the understanding of a recycling emerging industry mechanisms, act simultaneously on the environmental impact by recycling end of life products and on the business competitiveness by differentiation in new industrial activities. • The second method we developed must helps recycling R&D project managers to define a “recycling collaborative project”, the target market, the recycled product that will be manufactured and the potential structure of the future supply chain. • The third method is related to the question of partner selection with the proposal of a ranking method and the definitions of adapted criteria for such selections. In this respect we used Multi-Criteria Decision Making (MCDM) techniques to help industrials in this selection process. A case study is developed on the French textile recycling industry and a R&D collaborative project that introduces recyclable raw material from end of life vehicles and garments, for the development of a new product. An application of our research is conducted on a specific recycling collaborative project in order to discuss the initial results, and perspectives are highlighted for further research investigations

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39

Dormer, Mia Emilie. "A hidden life : how EAS (Era Appropriate Science) and professional investigators are marginalised in detective and historical detective fiction." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/33257.

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This by-practice project is the first to provide an extensive investigation of the marginalisation of era appropriate science (EAS) and professional investigators by detective and historical detective fiction authors. The purpose of the thesis is to analyse specific detective fiction authors from the earliest formats of the nineteenth century through to the 1990s and contemporary, selected historical detective fiction authors. Its aim is to examine the creation, development and perpetuation of the marginalisation tradition. This generic trend can be read as the authors privileging their detective’s innate skillset, metonymic connectivity and deductive abilities, while underplaying and belittling EAS and professional investigators. Chapter One establishes the project’s critique of the generic trend by considering parental authors, E. T. A Hoffmann, Edgar Allan Poe, Émile Gaboriau and Wilkie Collins. Reading how these authors instigated and purposed the downplaying demonstrates its founding within detective fiction at the earliest point. By comparing how the authors sidelined and omitted specific EAS and professional investigators, alongside science available at the time, this thesis provides a framework for examining how it continued in detective fiction. In following chapters, the framework established in Chapter One and the theoretical views of Charles Rzepka, Lee Horsley, Stephen Knight and Martin Priestman, are used to discuss how minimising EAS and professional investigators developed into a tradition; and became a generic trend in the recognised detective fiction formula that was used by Sir Arthur Conan Doyle, Freeman Wills Crofts, H. C. Bailey, R. Austin Freeman, Agatha Christie, Ruth Rendell and P. D. James. I then examine how the device transferred to historical detective fiction, using the framework to consider Ellis Peters, Umberto Eco and other selected contemporary authors of historical detective fiction. Throughout, the critical aspect considers how the trivialisation developed and perpetuated through a generic trend. The research concludes that there is a trend embedded within detective and historical detective fiction. One that was created, developed and perpetuated by authors to augment their fictional detective’s innate skillset and to help produce narratives using it is a creative process. It further concludes that the trend can be reimagined to plausibly use EAS and professional investigators in detective and historical detective fiction. The aim of the creative aspect of the project is to employ the research and demonstrate how the tradition can be successfully reinterpreted. To do so, the historical detective fiction novel A Hidden Life uses traditional features of the detective fiction formula to support and strengthen plausible EAS and professional investigators within the narrative. The end result is a historical detective fiction novel. One that proves the thesis conclusion and is fundamentally crafted by the critical research.

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40

Hsiao, Chia-Hung, and 蕭嘉宏. "Constructing a 3-D mesh model for electrical cardiac activity and ECG simulation." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/20660890156788947885.

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博士
國立陽明大學
醫學工程研究所
88
The 3-D ventricle model in this study was reconstructed from a series of MRI torso cross section data. We used a 3-D voxel array to represent the ventricle. As in cardiac simulations proposed by previous studies, the activation sequence and body surface ECG were simulated in this model. In order to reduce the amount of parameters in the model, we proposed another approach to simulate the electrical cardiac activity. A mesh model was constructed on the closed surface formed by epicardiacal and endocardiacal surfaces of the ventricle. The activation sequences on the epicardiac and endocardiac surfaces of the mesh model were simulated. As with the uniform double layer theorem, body surface ECG can be inducted in terms of epicardiacal and endocardiacal surface current sources. Consequently, we can also generate ECG waveforms corresponding to this mesh simulation. Both the depolarization sequence and ECG simulated by the mesh model resemble those generated by the 3-D voxel model. However, the mesh model greatly simplified the process of ECG simulation. In the mesh model, both the simulation of depolarization and ECG estimation were expressed in terms of clear and simple mathematical representations. We can analytically investigate the effects of parameters on the cardiac activation sequence and ECG from mesh model. It could be a useful tool to numerically study the relation of ECG waveforms and electrical activity of the heart.

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Lee, Che-Wei, and 李哲瑋. "Real-Time Patient-Specific ECG classification by 1-D Convolutional Neural Networks and Delineation." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/5qm8r8.

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碩士
國立臺灣大學
電子工程學研究所
106
Goal: This thesis presents a fast and accurate patient specific electrocardiogram (ECG) classification and monitoring system with relatively small training data size. Methods: An adaptive implementation of 1-D convolutional neural networks (CNNs) is inherently used to fuse the two major blocks of ECG classification without signal de-noising: feature extraction and classification. Therefore, for each patient, and individual and simple CNN will be trained by using a small common set and a patient specific data, this patient specific feature extraction method can further improve the classification performance. Since this also negates the necessity to extract any hand-crafted manual features, once a dedicated CNN is trained for a specific patient, it can solely be used to classify long ECG data streams in a fast and accurate manner. Using this method the structure of the CNN can be small, allowing this solution to be implemented for real-time ECG monitoring and early alert systems on wearable devices. Results: The results are evaluated over the MIT-BIH arrhythmia data benchmark database, the proposed solution achieves a superior classification performance than most of the state-of-the-art methods, or have much lower computation complexity than other NN solutions for the detection of ventricular ectopic beats and supraventricular ectopic beats. Conclusion: Once a dedicated CNN is trained, it can be used to classify long data streams for an individual patient with extremely low computation complexity with high accuracy. In addition, due to its simple and parameter invariant nature, the proposed system is extremely generic, thus applicable to any ECG dataset.

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42

He, Jinyuan. "Automated Heart Arrhythmia Detection from Electrocardiographic Data." Thesis, 2020. https://vuir.vu.edu.au/41284/.

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Heart arrhythmia is a severe heart problem, which threatens people’s lives by pre- venting their hearts from pumping enough blood into vital organs. Arrhythmia has been a major worldwide health problem for years, accounting for nearly 12% of global deaths every year. The research of automated heartbeat classification is highly demanded, which provides a cost-effective screening for heart arrhythmia and allows at-risk patients to receive timely treatments. To construct an effective automated heartbeat classification model from ECG recordings for arrhythmia de- tection, several key challenges must be addressed, including data quality, heartbeat segmentation range, data imbalance problem, intra and inter-patients variations, identification of supraventricular ectopic heartbeats from normal heartbeats, and model interpretability. This thesis comprehensively discusses these challenges and proposes four practical models to gradually tackle the heartbeat classification task. Specifically, in Chapter 3, a model named D-ECG is proposed to solve the problems suffered by previous methods of applying a standalone classifier and us- ing a static feature set to classify all heartbeat types. D-ECG introduces the dynamic ensemble selection techniques in heartbeat classification for the first time and incorporates a result regulator to improve the disease heartbeats detection performance. Although the dynamic ensemble selection technique has introduced visible improvements in the heartbeat classification task, they also brought some disadvantages. The dynamic selection nature, which determines the best classifiers according to the sample to be predicted, can result in a delay of the model predic- tion, making the model less practical in online detection scenarios. In Chapter 4, the author proposes a novel pyramid-like model to tackle this problem. The model adopts a dual-channel classification strategy and customizes a binary classification algorithm that takes neighbor-related information into account to assist disease heartbeats detection. Compared to the D-ECG framework, the pyramid-like model can provide more timely response to an unknown heartbeat while maintaining a good classification performance as the D-ECG framework. It has the potential to be applied in online detection scenarios. In Chapter 5, the author examines the recent advances brought by deep neural networks and proposes a DNN-based solution named Multi-channels Convolution Neural Network (MCHCNN) to solve the problems of current deep-learning based heartbeat classification models. As an improvement, the proposed network accepts raw ECG heartbeat and heart rhythm (RR-intervals) as inputs and uses different sizes of convolution filters in parallel to capture temporal and frequency patterns from ECG signals. The experimental results have shown visible improvements brought by MCHCNN. However, there is still a long way before MCHCNN can make practical impacts because its performance of S-type heartbeats detection is still relatively low. To tackle this problem, the author investigates the potential causes to the problem and proposes an advanced two-step DNN-based classification framework in Chapter 6. Due to the observed difficulty of detecting S-type heart- beats from N -type heartbeats, the proposed framework trains a deep dual-channel convolutional neural network (DDCNN) which accepts segmented heartbeats as input in the first step to classify V-type, F-type and Q-type heartbeats. At this stage, S-type and N-type heartbeats are not the targets, so they are put into one bundle to be studied in the next step. In the second step, a central-towards LSTM supportive model (CLSM) is specially designed to distinguish S-type heart- beats from N-type ones. The RR-intervals of a heartbeat and its neighbors are arranged in sequence form, serving as the input to CLSM. In particular, CLSM learns and extracts hidden temporal dependency between heartbeats by processing the input RR-interval sequence in central-towards directions. Instead of using raw individual RR-intervals, the abstractive, mutual-connected temporal information provides stronger and more stable support for identifying the problematic S-type heartbeats. Besides, as an improvement as well as a necessary driver for activating the CLSM, a rule-based data augmentation method is also proposed to supply high-quality synthetic samples for the under-represented S-type RR-interval se- quences. Extensive experiments are conducted to provide a comprehensive evaluation for each proposed model. The results prove that the research of heartbeat classification presented in this thesis brings practical ideas and solutions to the arrhythmia detection problem.

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Ye, Kun. "Inter-patient electrocardiogram heartbeat classification with 2-D convolutional neural network." Thesis, 2021. http://hdl.handle.net/1828/12586.

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Advanced computer technologies can transform the traditional electrocardiogram (ECG) monitoring system for better efficiency and accuracy. ECG records a heart's electrical activity using electrodes placed on the skin, and it has become an essential tool for arrhythmia detection. The complexity comes from the variety of patients' heartbeats and massive amounts of information for humans to process correctly. The first part of the thesis presents an image based two-dimensional convolution neural network (CNN) to classify the arrhythmia heartbeats with inter-patient paradigm. It includes a new data pre-processing method. The inter-patient paradigm simulates the practical use case of an ECG heartbeat classifier. Compared to the reported work in the literature, the proposed solution achieves superior experiment results. The rest of the thesis introduces the remote ECG monitoring system. The RESTful API design concepts of the system are described. The proposed API supports an efficient and secure way of interaction between each module in this remote monitoring system.
Graduate

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Yu, Chung-Ke, and 游忠科. "Applying QFD and TRIZ Eco-Innovative Design to the R&D of Notebook Computer." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/ch4pgk.

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碩士
國立臺北科技大學
工業工程與管理系EMBA班
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In recent years, the demand of notebook computer (NB) has trended to be over that of desktop personal computers. Since the variety of customers’ needs and environmental concerns are dramatically increasing, incremental improvements for NB may not meet the rapid change. Therefore, innovative design and green design have become critical and inevitable issues for NB designers and manufacturers in Taiwan at present time.This study applies four phases Quality Function Deployment (QFD I –QFD IV) to turn NB customers’ needs into required design attributes, components or modules, process operations and production. That is, concurrent engineering are readily implementd to proactively address potential problems in NB concept development. In this manner, many enviromental contradictions or problems arising in product design, product architecture, manufacturing process, and shop floor control for NB can be explored and prevented in this stage. Secondly, TRIZ theory, 40 TRIZ innovation principles, contradiction matrix, and eco-efficiency elements are utilized to inspire the green-design solutions for major contradictions or problems occuring in QFD I –QFD IV. Based on the suggestions and guidaness by eco-efficiency elements and TRIZ innovative principles, the results show that innovative feasible solutions focusing on the major contradictions or problems occuring in each NB QFD phase can be quickly developed and implemented. Less engineering changes in testing and refinement phase, more enviromental safety, robuster product performance, and less R&D project budget are achieved by the combination of four phase QFDs, TRIZ, and green-design proposed by this study. In addition, same practice can be utilized for other electrical consumer products to reduce R&D effort and to enhance the quick response of designer and manufacturers.

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Mendes, António Manuel da Silva. "Impacte do conceito ECO na cadeia de abastecimento e no marketing do vinho Foral D. Henrique." Master's thesis, 2017. http://hdl.handle.net/10400.14/30750.

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As recentes alterações climáticas ditam um novo paradigma na gestão, um equilíbrio dinâmico entre sustentabilidade e lucro. O empreendedorismo no setor do vinho poderá passar pelo green management, visando criar valor acrescentado ao produto e consequente vantagem competitiva. Elaborou-se um processo de produção “ECO” para a marca Foral D. Henrique, utilizando garrafas mais leves, com dimensões que permitem o transporte de quantidades maiores. A produção efetiva do Foral D. Henrique “ECO” permitiu analisar a influência na decisão de compra do aspeto da garrafa e da menção “ECO” e ainda o valor acrescentado à marca em lucro e notoriedade, utilizando como ponto de comparação o Foral D. Henrique 2015 e o Foral D. Henrique “Ecova Sedução”. O presente estudo um misto de Estudo Causal e Estudo Descritivo, que analisa de forma sistemática, lógica e robusta os comportamentos de compra dos inquiridos relativamente ao novo produto, criado exclusivamente para ser objeto deste trabalho. Foi também efetuada a análise comparativa da estrutura de custos dos produtos e da respetiva cadeia de abastecimento, fazendo uma projeção do impacte económico nos custos e proveitos da Adega Cooperativa de Mangualde, CRL. Estas alterações resultaram, do ponto de vista económico, numa redução de 4,61% no custo de produção e transporte, do ponto de vista ambiental, numa diminuição de 7,06% nos resíduos introduzidos na cadeia de abastecimento. Os resultados do inquérito indicam que os consumidores, quando menos informados, dão mais importância ao aspeto; quando mais informados, valorizam o preço. O conceito Eco é válido, desde que a mensagem seja transmitida corretamente ao consumidor, estando 67,2% dos inquiridos dispostos a pagar mais, o que pode ter um impacte de 4.48% na faturação no posto de venda. A chave do sucesso do negócio verde é a comunicação.
Climate change imposes a new paradigm in Management, a dynamic balance between sustainability and profit. Entrepreneurship in wine business may go through Green Management, aiming to generate increased value to product and consequent competitive advantage. An "ECO" production process was developed for the Foral D. Henrique brand, using lighter bottles with dimensions that allow the transport of larger quantities. The actual production of Foral D. Henrique "ECO" made it possible to analyze the influence on the purchase decision of the bottle and the "ECO" brand, and the value added to the brand in profit and notoriety, using Foral D Henrique 2015 and the Foral D. Henrique "Ecova Sedução" as balance. This study is a mixture of Causal Study and Descriptive Study that systematically, logically and robustly analyzes the buying behaviors of the respondents regarding the new product created exclusively to be object of this study. A comparative analysis of the cost structure of the products and their supply chain was also made, with a projection of the economic impact on the costs and revenues of the Adega Cooperativa de Mangualde, CRL. These changes have resulted in a reduction in the cost of production and transport of 4.61% and from the environmental point of view, in a decrease of 7,06% in waste introduced into the supply chain. The results of the survey indicate that consumers when less informed give more importance to the aspect and when more informed value the price. The Eco concept is valid as long as the message is correctly communicated to the consumer, with 67.2% of the respondents willing to pay more, which can have a 4.48% impact on the billing at the point of sale. The key to green business success is communication.

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Marx, Ute [Verfasser]. "Experimentelle Untersuchungen zur Effizienzsteigerung der In-vitro-Produktion von Rinderembryonen durch Fertilisation aktivierter Oozyten sowie durch Vorbehandlung züchterisch wertvoller Schlachtkühe mit eCG / vorgelegt von Ute Marx." 2002. http://d-nb.info/965594599/34.

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Peuckmann, Katja [Verfasser]. "Untersuchungen zur Feststellung von Beziehungen zwischen Sameneigenschaften, Besamungsergebnissen und der IVF-Tauglichkeit von Prüfbullen : sowie Untersuchungen zur Steigerung der Blastozystenausbeute nach IVF von Oozyten aus Eierstöcken geschlachteter Zuchttiere durch Vorbehandlung mit eCG und Mineralstoffen / vorgelegt von Katja Peuckmann." 2000. http://d-nb.info/95994561X/34.

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"Alteração da composição dos polissacarídeos da parede celular de Nicotiana tabacum, pela modulação da expressão do gene uxs que codifica a enzima UDP-D-glucuronato descarboxilase (EC 4.1.1.35)." Tese, Biblioteca Digital de Teses e Dissertações da USP, 2007. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-04042007-142713/.

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Franque, Frank Bivar. "Mobile Payment Continuance Intention." Doctoral thesis, 2022. http://hdl.handle.net/10362/136212.

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