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1

Petersen, Craig. "D-Lactic Acidosis." Nutrition in Clinical Practice 20, no. 6 (2005): 634–45. http://dx.doi.org/10.1177/0115426505020006634.

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2

Hayat, Muhammad S., Soon-IL Song, Zandra K. Ferrufino-Ponce, Nausheen Naz, and Frederick W. Ruymann. "D-Lactic Acidosis." American Journal of Gastroenterology 101 (September 2006): S377. http://dx.doi.org/10.14309/00000434-200609001-00947.

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3

Dunlop, Robert H., and Paul B. Hammond. "D-LACTIC ACIDOSIS OF RUMINANTS*†." Annals of the New York Academy of Sciences 119, no. 3 (2006): 1109–32. http://dx.doi.org/10.1111/j.1749-6632.1965.tb47466.x.

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4

Lorenz, Ingrid. "d-Lactic acidosis in calves." Veterinary Journal 179, no. 2 (2009): 197–203. http://dx.doi.org/10.1016/j.tvjl.2007.08.028.

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5

Lorenz, I., and A. Lorch. "D-lactic acidosis in lambs." Veterinary Record 164, no. 6 (2009): 174–75. http://dx.doi.org/10.1136/vr.164.6.174.

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6

Coronado, Boris E. "Antibiotic-Induced D-Lactic Acidosis." Annals of Internal Medicine 122, no. 11 (1995): 839. http://dx.doi.org/10.7326/0003-4819-122-11-199506010-00005.

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7

Bongaerts, G., J. Tolboom, T. Naber, J. Bakkeren, R. Severijnen, and H. Willems. "D-lactic acidemia and aciduria in pediatric and adult patients with short bowel syndrome." Clinical Chemistry 41, no. 1 (1995): 107–10. http://dx.doi.org/10.1093/clinchem/41.1.107.

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Abstract D-Lactate produced by abundant intestinal lactobacilli during acidotic episodes in short bowel (SB) patients is commonly regarded as a main factor in the pathogenesis of SB syndrome-associated (D-lactic) acidosis. Since we had observed that gram-positive bacteria, mainly lactobacilli, were abundant even in the absence of acidosis, we studied serum concentrations and urinary excretions of D- and L-lactate in young and adult SB patients, especially during nonacidotic periods. Serum L-lactate and urinary L-lactate excretion were similar in adults and children. Serum D-lactate and urinary
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8

Mack, David R. "D(—)–Lactic Acid Producing Probiotics, D(—)–Lactic Acidosis and Infants." Canadian Journal of Gastroenterology 18, no. 11 (2004): 671–75. http://dx.doi.org/10.1155/2004/342583.

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There is mounting evidence that ingestion of selected probiotics can modify disease morbidity for specific conditions affecting humans, and there is growing interest in the amelioration or prevention of disease with probiotics. Modulation in gene expression of the cellular elements of the intestinal mucosa and interbacterial interactions are leading theories as to the mechanism whereby probiotics can effect benefit for the host. Furthermore, gene-environmental interactions are considered to be important in the development of disease in those at genetic risk. With the intestinal tract harbourin
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9

Weemaes, Matthias, Martin Hiele, and Pieter Vermeersch. "High anion gap metabolic acidosis caused by D-lactate." Biochemia medica 30, no. 1 (2020): 153–57. http://dx.doi.org/10.11613/bm.2020.011001.

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Introduction: D-lactic acidosis is an uncommon cause of high anion gap acidosis. Materials and methods: A 35-year old woman was admitted to the emergency room with somnolence, drowsiness, dizziness, incoherent speech and drunk appearance. Her past medical history included a Roux-en-Y bypass. Point-of-care venous blood analysis revealed a high anion gap acidosis. Based on the clinical presentation, routine laboratory results and negative toxicology screening, D-lactate and 5-oxoprolinuria were considered as the most likely causes of the high anion gap acidosis. Urine organic acid analysis revea
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10

Planas-Vilaseca, Alejandra, Fernando Guerrero-Pérez, Agustina P. Marengo, Rafael Lopez-Urdiales, and Núria Virgili-Casas. "D-lactic acidosis: A rare cause of metabolic acidosis." Endocrinología y Nutrición (English Edition) 63, no. 8 (2016): 433–34. http://dx.doi.org/10.1016/j.endoen.2016.09.009.

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11

Lorenz, Ingrid, and Arcangelo Gentile. "d-Lactic Acidosis in Neonatal Ruminants." Veterinary Clinics of North America: Food Animal Practice 30, no. 2 (2014): 317–31. http://dx.doi.org/10.1016/j.cvfa.2014.03.004.

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12

Marshall, George A. "d-Lactic acidosis in haematological malignancy." Clinica Chimica Acta 444 (April 2015): 318. http://dx.doi.org/10.1016/j.cca.2015.02.024.

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13

Bongaerts, Ger, Jan Bakkeren, René Severijnen, et al. "Lactobacilli and Acidosis in Children With Short Small Bowel." Journal of Pediatric Gastroenterology and Nutrition 30, no. 3 (2000): 288–93. http://dx.doi.org/10.1002/j.1536-4801.2000.tb02728.x.

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ABSTRACTBackground:In patients with a short small bowel, D‐lactic acidemia and D‐lactic aciduria are caused by intestinal lactobacilli. The purpose of this study was to obtain a detailed picture of the metabolic acidosis in young children with short small bowel.Methods:Feces, blood, and urine of children with short small bowel and acidosis were studied microbiologically and/or biochemically.Results:Previous findings were confirmed that more than 60% of the fecal flora of patients with small short bowel, who are not receiving antibiotics, consists of lactic acid‐producing lactobacilli. In blood
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14

Gossett, K. A., D. D. French, B. Cleghorn, and G. E. Church. "Effect of acute acidemia on blood biochemical variables in healthy ponies." American Journal of Veterinary Research 51, no. 9 (1990): 1375–79. http://dx.doi.org/10.2460/ajvr.1990.51.09.1375.

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SUMMARY l-Lactic acid and d, l-lactic acid infusion in ponies resulted in metabolic acidosis with high anion gap (ag). Increased ag was explained entirely by increased blood l- and d-lactate concentrations. Hydrochloric acid infusion caused metabolic acidosis with decreased ag. Saline (NaCl) infusion caused mild metabolic acidosis, with no significant change in ag. Plasma K+ concentration was decreased by all types of infusions, with a maximum of 0.50, 0.25, 0.40, 0.50 mmol/L below baseline at the end of infusion in the l-lactic acid-, d,l-lactic acid-, HC1-, and NaCl-infused ponies, respectiv
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15

Vella, A., and G. Farrugia. "D-lactic acidosis: pathologic consequence of saprophytism." Mayo Clinic Proceedings 73, no. 5 (1998): 451–56. http://dx.doi.org/10.4065/73.5.451.

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16

Vella, Adrian, and Gianrico Farrugia. "D-Lactic Acidosis: Pathologic Consequence of Saprophytism." Mayo Clinic Proceedings 73, no. 5 (1998): 451–56. http://dx.doi.org/10.1016/s0025-6196(11)63729-4.

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17

Kowlgi, N. Gurukripa, and Lovely Chhabra. "D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome." Gastroenterology Research and Practice 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/476215.

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Анотація:
D-lactic acidosis or D-lactate encephalopathy is a rare condition that occurs primarily in individuals who have a history of short bowel syndrome. The unabsorbed carbohydrates act as a substrate for colonic bacteria to form D-lactic acid among other organic acids. The acidic pH generated as a result of D-lactate production further propagates production of D-lactic acid, hence giving rise to a vicious cycle. D-lactic acid accumulation in the blood can cause neurologic symptoms such as delirium, ataxia, and slurred speech. Diagnosis is made by a combination of clinical and laboratory data includ
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18

Yamase, Yuko, Hai Huang, Yoshihiro Mitoh, Masahiko Egusa, Takuya Miyawaki, and Ryusuke Yoshida. "Taste Responses and Ingestive Behaviors to Ingredients of Fermented Milk in Mice." Foods 12, no. 6 (2023): 1150. http://dx.doi.org/10.3390/foods12061150.

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Fermented milk is consumed worldwide because of its nutritious and healthful qualities. Although it is somewhat sour, causing some to dislike it, few studies have examined taste aspects of its ingredients. Wild-type mice and T1R3-GFP-KO mice lacking sweet/umami receptors were tested with various taste components (sucrose, galactose, lactose, galacto-oligosaccharides, fructo-oligosaccharides, l- and d-lactic acid) using 48 h two-bottle tests and short-term lick tests. d-lactic acid levels were measured after the ingestion of d- or; l-lactic acid or water to evaluate d-lactic acidosis. In wild-t
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19

Takahashi, Kazuhiro, Hideo Terashima, Keisuke Kohno, and Nobuhiro Ohkohchi. "A Stand-Alone Synbiotic Treatment for the Prevention of D-Lactic Acidosis in Short Bowel Syndrome." International Surgery 98, no. 2 (2013): 110–13. http://dx.doi.org/10.9738/cc169.

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Abstract Synbiotics are combinations of probiotics and prebiotics that have recently been used in the context of various gastrointestinal diseases, including infectious enteritis, inflammatory bowel disease, and bowel obstruction. We encountered a patient with recurrent D-lactic acidosis who was treated successfully for long periods using synbiotics. The patient was diagnosed as having short bowel syndrome and had recurrent episodes of neurologic dysfunction due to D-lactic acidosis. In addition to fasting, the patient had been treated with antibiotics to eliminate D-lactate–producing bacteria
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20

Jain, Avni, Kiran Jhinger, and Jonathon Bellas. "Recurrent Encephalopathy and Severe Anion Gap Metabolic Acidosis in a Patient with Short Bowel: It Is D-Lactic Acidosis." Case Reports in Gastroenterology 15, no. 1 (2021): 92–96. http://dx.doi.org/10.1159/000509952.

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Анотація:
D-lactic acidosis is a rare and potentially underrecognized condition in patients with short bowel syndrome. We present the case of a 61-year-old female with a history of an ileojejunal bypass at age 18 who presented to hospital with acute-onset encephalopathy, ataxia, and severe anion gap metabolic acidosis (AGMA). On initial investigations there were no identifiable etiologies for the AGMA. Further history revealed that she had been experiencing these symptoms on a recurrent basis for the past 40 years. An oral carbohydrate load was given to the patient in hospital which reproduced her sympt
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21

Kang, Kyung Pyo, Sik Lee, and Sung Kyew Kang. "D-Lactic Acidosis in Humans: Review of Update." Electrolyte & Blood Pressure 4, no. 1 (2006): 53. http://dx.doi.org/10.5049/ebp.2006.4.1.53.

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22

Ali, Hasan, Sung Choi, Yi Jiang, Ahmed M. Ahmed, Konstantinos Damiris, and Sushil Ahlawat. "S2782 D-Lactic Acidosis in Short Bowel Syndrome." American Journal of Gastroenterology 115, no. 1 (2020): S1454—S1455. http://dx.doi.org/10.14309/01.ajg.0000713176.27800.44.

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23

Bianchetti, Davide G. A. M., Giacomo S. Amelio, Sebastiano A. G. Lava, et al. "D-lactic acidosis in humans: systematic literature review." Pediatric Nephrology 33, no. 4 (2017): 673–81. http://dx.doi.org/10.1007/s00467-017-3844-8.

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24

Zhang, D. L. "D-lactic acidosis secondary to short bowel syndrome." Postgraduate Medical Journal 79, no. 928 (2003): 110–12. http://dx.doi.org/10.1136/pmj.79.928.110.

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25

Jackson, D. C., E. A. Arendt, K. C. Inman, R. G. Lawler, G. Panol, and J. S. Wasser. "31P-NMR study of normoxic and anoxic perfused turtle heart during graded CO2 and lactic acidosis." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 260, no. 6 (1991): R1130—R1136. http://dx.doi.org/10.1152/ajpregu.1991.260.6.r1130.

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We studied the effects of graded acidosis (both CO2 and lactic acid) and anoxia on intracellular pH (pHi) regulation, high-energy phosphates, and mechanical function of isolated perfused hearts of the turtle (Chrysemys picta bellii) at 20 degrees C using 31P-nuclear magnetic resonance (NMR) spectroscopy. During CO2 acidosis, anoxia had no effect on apparent nonbicarbonate buffer value (d[HCO3-]/dpHi = 71 and 89 mM/pH in normoxia and anoxia, respectively) or on pHi regulation (dpHi/dpHe = 0.52 and 0.43 in normoxia and anoxia, respectively, where pHe is extracellular pH). During normoxic lactic
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26

Rosenthal, Philip, and Michael Pesce. "Long." Journal of Pediatric Gastroenterology and Nutrition 4, no. 4 (1985): 674–76. http://dx.doi.org/10.1002/j.1536-4801.1985.tb08929.x.

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SummaryA case of Dlactic acidosis in a 2 1/2 year old child followed for 11 months is reported. The infant had previously undergone extensive small intestinal resection for midgut volvulus. Diagnosis was confirmed by measurement of plasma D lactate. Metabolic acidosis, increased anion gap, ataxia, and lethargy in patients with small intestinal resection warrant investigation for D lactic acidosis. The presumed etiology is absorption of Dlactic acid produced by bacterial fermentation of carbohydrate in the colon. Antibiotic treatment resulted in prompt resolution of symptoms in this case. Prosp
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27

Remund, Barblin, Bahtiyar Yilmaz, and Christiane Sokollik. "D-Lactate: Implications for Gastrointestinal Diseases." Children 10, no. 6 (2023): 945. http://dx.doi.org/10.3390/children10060945.

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Анотація:
D-lactate is produced in very low amounts in human tissues. However, certain bacteria in the human intestine produce D-lactate. In some gastrointestinal diseases, increased bacterial D-lactate production and uptake from the gut into the bloodstream take place. In its extreme, excessive accumulation of D-lactate in humans can lead to potentially life-threatening D-lactic acidosis. This metabolic phenomenon is well described in pediatric patients with short bowel syndrome. Less is known about a subclinical rise in D-lactate. We discuss in this review the pathophysiology of D-lactate in the human
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28

Gentile, A., S. Sconza, I. Lorenz, et al. "d-Lactic Acidosis in Calves as a Consequence of Experimentally Induced Ruminal Acidosis." Journal of Veterinary Medicine Series A 51, no. 2 (2004): 64–70. http://dx.doi.org/10.1111/j.1439-0442.2004.00600.x.

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29

Abeysekara, Saman, Jonathan M. Naylor, Andrew W. A. Wassef, Ulyana Isak, and Gordon A. Zello. "d-Lactic acid-induced neurotoxicity in a calf model." American Journal of Physiology-Endocrinology and Metabolism 293, no. 2 (2007): E558—E565. http://dx.doi.org/10.1152/ajpendo.00063.2007.

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-Lactic acidosis (DAC) occurs as a complication of short-bowel syndrome in humans and in a variety of other gastrointestinal disorders in monogastrics and ruminants. DAC is associated with signs of impaired central nervous system (CNS) function including ataxia and coma. The objective of this experiment was to determine whether either acidification of nervous tissue or d-lactic acid is responsible for decreased neurological function. Eight Holstein calves (32 ± 11 days, 70 ± 10 kg) were surgically catheterized with indwelling intravenous jugular and atlanto-occipital space cerebrospinal fluid
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30

Rosenthal, P. "D-lactic acidosis in patients with short bowel syndrome." Clinical Chemistry 41, no. 5 (1995): 767–68. http://dx.doi.org/10.1093/clinchem/41.5.767.

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31

Kadakia, Shailesh C. "D-Lactic Acidosis in a Patient with Jejunoileal Bypass." Journal of Clinical Gastroenterology 20, no. 2 (1995): 154–56. http://dx.doi.org/10.1097/00004836-199503000-00019.

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32

Vitetta, Luis, Samantha Coulson, Michael Thomsen, Tony Nguyen, and Sean Hall. "Probiotics, D–Lactic acidosis, oxidative stress and strain specificity." Gut Microbes 8, no. 4 (2017): 311–22. http://dx.doi.org/10.1080/19490976.2017.1279379.

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33

Gurevitch, J., B. Sela, A. Jonas, H. Golan, Y. Yahav, and JH Passwell. "D-Lactic acidosis: a treatable encephalopathy in pediatric patients." Acta Paediatrica 82, no. 1 (1993): 119–21. http://dx.doi.org/10.1111/j.1651-2227.1993.tb12538.x.

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34

Chiatto, Fabrizia, Lynette Forsythe, Riccardo Coletta, Valeria Solari, Bashar Alseiri, and Antonino Morabito. "D-lactic Acidosis in Children with Short Bowel Syndrome." Transplantation 101 (June 2017): S133. http://dx.doi.org/10.1097/01.tp.0000521485.05347.d3.

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35

Spillane, K., K. Nagendran, P. F. Prior, S. Tabaqchali, and M. Wilks. "Serial electroencephalograms in a patient with d-lactic acidosis." Electroencephalography and Clinical Neurophysiology 91, no. 5 (1994): 403–5. http://dx.doi.org/10.1016/0013-4694(94)90126-0.

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36

Narula, Rajesh K., Amr El Shafei, Dinesh Ramaiah, and Paul G. Schmitz. "d -lactic acidosis 23 years after jejuno-ileal bypass." American Journal of Kidney Diseases 36, no. 2 (2000): e9.1-e9.4. http://dx.doi.org/10.1053/ajkd.2000.9005.

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37

Berman, Casey M., and Russell J. Merritt. "Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis." Nutrition in Clinical Practice 33, no. 6 (2018): 897–901. http://dx.doi.org/10.1002/ncp.10063.

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38

Yilmaz, Bahtiyar, Susanne Schibli, Andrew J. Macpherson, and Christiane Sokollik. "D-lactic Acidosis: Successful Suppression of D-lactate–Producing Lactobacillus by Probiotics." Pediatrics 142, no. 3 (2018): e20180337. http://dx.doi.org/10.1542/peds.2018-0337.

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39

Alber, Jana, and Michael Föller. "Lactic acid induces fibroblast growth factor 23 (FGF23) production in UMR106 osteoblast-like cells." Molecular and Cellular Biochemistry 477, no. 2 (2021): 363–70. http://dx.doi.org/10.1007/s11010-021-04287-y.

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AbstractEndocrine and paracrine fibroblast growth factor 23 (FGF23) is a protein predominantly produced by bone cells with strong impact on phosphate and vitamin D metabolism by targeting the kidney. Plasma FGF23 concentration early rises in kidney and cardiovascular diseases correlating with progression and outcome. Lactic acid is generated in anaerobic glycolysis. Lactic acidosis is the consequence of various physiological and pathological conditions and may be fatal. Since FGF23 production is stimulated by inflammation and lactic acid induces pro-inflammatory signaling, we investigated whet
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40

Podušel, Vladimír, Simona Morgošová, Pavol Majdák, and Jurina Sadloňová. "D-lactic acidosis - a rare complication of short bowel syndrome." Vnitřní lékařství 67, no. 5 (2021): e28-e33. http://dx.doi.org/10.36290/vnl.2021.085.

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41

Fabian, Elisabeth, Ludwig Kramer, Franz Siebert, et al. "D-lactic acidosis – case report and review of the literature." Zeitschrift für Gastroenterologie 55, no. 01 (2016): 75–82. http://dx.doi.org/10.1055/s-0042-117647.

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42

Mayne, A. J., D. J. Handy, M. A. Preece, R. H. George, and I. W. Booth. "Dietary management of D-lactic acidosis in short bowel syndrome." Archives of Disease in Childhood 65, no. 2 (1990): 229–31. http://dx.doi.org/10.1136/adc.65.2.229.

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43

Darnell, Hannah, Aaron Brenner, and Deborah Flomenhoft. "S4713 Short Bowel Syndrome Resulting in Chronic D-Lactic Acidosis." American Journal of Gastroenterology 119, no. 10S (2024): S2982—S2983. http://dx.doi.org/10.14309/01.ajg.0001048220.11535.50.

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44

Jover, Rodrigo, Julián León, JoséM Palazón, and JoséR Domínguez. "D-lactic acidosis associated with use of medium-chain triglycerides." Lancet 346, no. 8970 (1995): 314. http://dx.doi.org/10.1016/s0140-6736(95)92202-4.

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45

Zanza, Christian, Valentina Facelli, Tastiana Romenskaya, et al. "Lactic Acidosis Related to Pharmacotherapy and Human Diseases." Pharmaceuticals 15, no. 12 (2022): 1496. http://dx.doi.org/10.3390/ph15121496.

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Анотація:
Lactic acidosis represents one of the most common conditions that can compromise the health of intensive care unit (ICU) patients, increasing the mortality of patients with high levels of Lactate who do not receive a proper treatment within the first 6 h of hospitalization. There are two enantiomers of lactic acid: L-lactic acid (when the concentration increases, it can lead to a state of severe acidemia risking cardiovascular collapse, causing an increase in mortality in ICU patients) and D lactic acid (produced in the human organism by microbiota and its production increases during some path
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46

Hutton, P. G., Z. Durmic, and P. E. Vercoe. "Investigating Eremophila glabra as a bioactive agent for preventing lactic acidosis in sheep." Animal Production Science 50, no. 6 (2010): 449. http://dx.doi.org/10.1071/an09191.

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The Australian native plant Eremophila glabra was tested as a potential agent for preventing lactic acidosis in sheep after it was observed to be effective against acidosis in vitro. Ruminally fistulated wethers were infused via rumen cannula with single doses of kibbled wheat (14 g/kg bodyweight) and either virginiamycin (Eskalin500; AB, 80 mg/kg of wheat plus 100 g milled oaten hay/kg of wheat, n = 6), E. glabra (EG, 100 g freeze-dried and milled leaf material per kg of wheat, n = 10) or milled oaten hay (Control, 100 g milled oaten hay/kg of wheat, n = 16). Rumen samples were collected imme
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HINOKI, Tomoya, Takehito OSHIO, Masao HIND, Masaaki OSHITA, and Yukari HARING. "D-lactic Acidosis after Massive Small Bowel Resection in a Child." Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 63, no. 7 (2002): 1700–1703. http://dx.doi.org/10.3919/jjsa.63.1700.

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Wang, Wallace, Christopher Ashley та Seth Richter. "D-Lactic Acidosis Presenting in Crohnʼs Disease with Short Bowel Syndrome". American Journal of Gastroenterology 104 (жовтень 2009): S285. http://dx.doi.org/10.14309/00000434-200910003-00772.

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Bongaerts, Ger, Jules Tolboom, Ton Naber, Jan Bakkeren, René Severijnen, and Hans Willems. "In Reply: D-Lactic Acidosis in Patients with Short Bowel Syndrome." Clinical Chemistry 41, no. 5 (1995): 768–69. http://dx.doi.org/10.1093/clinchem/41.5.768.

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Quigley, Eamonn M. M., Bruno Pot, and Mary Ellen Sanders. "‘Brain Fogginess’ and D-Lactic Acidosis: Probiotics Are Not the Cause." Clinical and Translational Gastroenterology 9, no. 9 (2018): e187. http://dx.doi.org/10.1038/s41424-018-0057-9.

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