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Статті в журналах з теми "DBFA"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Gao, Shilun, Yuan Gao, Ying Yang, Liming Jia, and Xuehuang Weng. "Exogenous Sucrose Supply Regulates the Physiological Index Levels Before the Flower Blooming and Fruit Abscission Stages in the Biodiesel Tree Sapindus mukorossi Gaertn." HortScience 57, no. 11 (2022): 1397–408. http://dx.doi.org/10.21273/hortsci16626-22.

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Nutrient deficiency leads to a high fruit abscission rate and low yields of Sapindus mukorossi Gaertn. (Soapberry), which is one of the most widely cultivated biodiesel feedstock forests in China. Exogenous sucrose can provide a solution to nutrient deficiency and fruit abscission leading to low yields; therefore, it was applied to whole trees at two stages, 20 days before blooming (DBB stage) and before fruit abscission [days before fruit abscission (DBFA) stage]. Six sucrose concentrations, 0%, 1%, 1.5%, 3%, 5%, and 7%, were sprayed three times using a completely randomized block design with

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2

Habe, Hiroshi, Jin-Sung Chung, Hiroyuki Kato, et al. "Characterization of the Upper Pathway Genes for Fluorene Metabolism in Terrabacter sp. Strain DBF63." Journal of Bacteriology 186, no. 17 (2004): 5938–44. http://dx.doi.org/10.1128/jb.186.17.5938-5944.2004.

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ABSTRACT Genes involved in the degradation of fluorene to phthalate were characterized in the fluorene degrader Terrabacter sp. strain DBF63. The initial attack on both fluorene and 9-fluorenone was catalyzed by DbfA to yield 9-fluorenol and 1,1a-dihydroxy-1-hydro-9-fluorenone, respectively. The FlnB protein exhibited activities against both 9-fluorenol and 1,1a-dihydroxy-1-hydro-9-fluorenone to produce 9-fluorenone and 2′-carboxy-2,3-dihydroxybiphenyl, respectively. FlnD is a heteromeric protein encoded by flnD1 and ORF16, being a member of the class III two-subunit extradiol dioxygenase. Fln

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3

Heba, M. Elewe*. "ANGULAR BASED MODEL FOR RFID NETWORK PLANNING FOR WAREHOUSE MANAGEMENT SYSTEM." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 4, no. 10 (2017): 132–37. https://doi.org/10.5281/zenodo.1034499.

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Large scale warehouses often apply the RFID Network Planning (RNP) strategy to efficiently track assets, which can lead to significant revenue gain. For this reason, this research has developed a three dimension RFID network planning model that can improve warehouse management. The mathematical model of the RFID network planning is concerned with two major issues. The first one is the correlation between the reader height and the rack levels. The second issue is to specify the optimal tag coverage based on the elliptical interrogation reader range. The DBFA algorithm is used as a method to eva

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4

Picu, Mihaela. "A Study of Vertical Vibration Transmissibility by the Human Body." Applied Mechanics and Materials 325-326 (June 2013): 152–57. http://dx.doi.org/10.4028/www.scientific.net/amm.325-326.152.

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The transmission of longitudinal vibration (generated by the vibrating platform Brüel & Kjær 4827) in the whole body of ten subjects was investigated. Altogether 200 individual tests were made. Vibration was measured with 356A16 PCB Piezotronics triaxial accelerometers fixed to the toes, ankles, lumbar, cervical, fingers, elbow and shoulder. Vibrations were analyzed with a multiple acquisition vibrations system NetdB. Data were processed using dBFA Suite. Vibration time was 1min and frequency range was between 10-40Hz, because the low frequencies are the resonance frequencies for the huma

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5

Du, Gaoming, Chao Tian, Zhenmin Li, et al. "Delay Bound Optimization in NoC Using a Discrete Firefly Algorithm." Electronics 8, no. 12 (2019): 1507. http://dx.doi.org/10.3390/electronics8121507.

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The delay bound in system on chips (SoC) represents the worst-case traverse time of on-chip communication. In network on chip (NoC)-based SoC, optimizing the delay bound is challenging due to two aspects: (1) the delay bound is hard to obtain by traditional methods such as simulation; (2) the delay bound changes with the different application mappings. In this paper, we propose a delay bound optimization method using discrete firefly optimization algorithms (DBFA). First, we present a formal analytical delay bound model based on network calculus for both unipath and multipath routing in NoCs.

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6

Bridges, Andrew A., Chenyi Fei, and Bonnie L. Bassler. "Identification of signaling pathways, matrix-digestion enzymes, and motility components controllingVibrio choleraebiofilm dispersal." Proceedings of the National Academy of Sciences 117, no. 51 (2020): 32639–47. http://dx.doi.org/10.1073/pnas.2021166117.

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Bacteria alternate between being free-swimming and existing as members of sessile multicellular communities called biofilms. The biofilm lifecycle occurs in three stages: cell attachment, biofilm maturation, and biofilm dispersal.Vibrio choleraebiofilms are hyperinfectious, and biofilm formation and dispersal are considered central to disease transmission. While biofilm formation is well studied, almost nothing is known about biofilm dispersal. Here, we conducted an imaging screen forV. choleraemutants that fail to disperse, revealing three classes of dispersal components: signal transduction

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7

Farhat, I. A. "A MODIFIED DYNAMIC BACTERIAL FORAGING ALGORITHM FOR AN ENHANCED POWER SYSTEM STATE ESTIMATION." مجلة الجامعة الأسمرية: العلوم التطبيقية 6, no. 5 (2021): 466–78. http://dx.doi.org/10.59743/aujas.v6i5.1501.

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Power systems are getting more complex with the ongoing growing of the ever changing energy demand. This dynamic situation of the electric power networks makes the control and monitoring of the system a crucial issue. In order to have an accurate real time monitoring and representative models, state estimation practices are essential. This requirement becomes more significant for nonlinear systems such as the electric power networks. The objective of the state estimation problem is to apply a variety of statistical and optimization methods in order to determine the best estimate of the power s

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8

Toyn, J. H., A. L. Johnson, and L. H. Johnston. "Segregation of unreplicated chromosomes in Saccharomyces cerevisiae reveals a novel G1/M-phase checkpoint." Molecular and Cellular Biology 15, no. 10 (1995): 5312–21. http://dx.doi.org/10.1128/mcb.15.10.5312.

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Saccharomyces cerevisiae dbf4 and cdc7 cell cycle mutants block initiation of DNA synthesis (i.e., are iDS mutants) at 37 degrees C and arrest the cell cycle with a 1C DNA content. Surprisingly, certain dbf4 and cdc7 strains divide their chromatin at 37 degrees C. We found that the activation of the Cdc28 mitotic protein kinase and the Dbf2 kinase occurred with the correct relative timing with respect to each other and the observed division of the unreplicated chromatin. Furthermore, the division of unreplicated chromatin depended on a functional spindle. Therefore, the observed nuclear divisi

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9

Aminov, Mirobbos Askar ugli. "MODELS OF PUBLIC-PRIVATE PARTNERSHIP, MECHANISMS OF IMPLEMENTATION." EURASIAN JOURNAL OF ACADEMIC RESEARCH 1, no. 4 (2021): 41–50. https://doi.org/10.5281/zenodo.5083313.

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Existing legal regulations based on different legal traditions and cultures, different levels of economic development and market relations, partnerships between public entities and the private sector in countries with different legal systems are different.  At the same time, based on the generalization of the experience of legal regulation of public-private partnership in different countries, models of public-private partnership are distinguished.

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10

Varrin, Angela E., Ajai A. Prasad, Rolf-Peter Scholz, Matthew D. Ramer, and Bernard P. Duncker. "A Mutation in Dbf4 Motif M Impairs Interactions with DNA Replication Factors and Confers Increased Resistance to Genotoxic Agents." Molecular and Cellular Biology 25, no. 17 (2005): 7494–504. http://dx.doi.org/10.1128/mcb.25.17.7494-7504.2005.

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ABSTRACT Dbf4/Cdc7 is required for DNA replication in Saccharomyces cerevisiae and appears to be a target in the S-phase checkpoint. Previously, a 186-amino-acid Dbf4 region that mediates interactions with both the origin recognition complex and Rad53 was identified. We now show this domain also mediates the association between Dbf4 and Mcm2, a key Dbf4/Cdc7 phosphorylation target. Two conserved sequences, the N and M motifs, have been identified within this Dbf4 region. Removing motif M (Dbf4ΔM) impairs the ability of Dbf4 to support normal cell cycle progression and abrogates the Dbf4-Mcm2 a

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11

Kitada, K., L. H. Johnston, T. Sugino, and A. Sugino. "Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition." Genetics 131, no. 1 (1992): 21–29. http://dx.doi.org/10.1093/genetics/131.1.21.

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Abstract When present on a multicopy plasmid, a gene from a Saccharomyces cerevisiae genomic library suppresses the temperature-sensitive cdc7-1 mutation. The gene was identified as DBF4, which was previously isolated by complementation in dbf4-1 mutant cells and is required for the G1----S phase progression of the cell cycle. DBF4 has an open reading frame encoding 695 amino acid residues and the predicted molecular mass of the gene product is 80 kD. The suppression is allele-specific because a CDC7 deletion is not suppressed by DBF4. Suppression is mitosis-specific and the sporulation defect

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12

Shariatnasery, Maria, Valentina Stein, Ines Teichert, and Ulrich Kück. "STRIPAK Dependent and Independent Phosphorylation of the SIN Kinase DBF2 Controls Fruiting Body Development and Cytokinesis during Septation and Ascospore Formation in Sordaria macrospora." Journal of Fungi 10, no. 3 (2024): 177. http://dx.doi.org/10.3390/jof10030177.

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The supramolecular striatin-interacting phosphatases and kinases (STRIPAK) complex is highly conserved in eukaryotes and controls diverse developmental processes in fungi. STRIPAK is genetically and physically linked to the Hippo-related septation initiation network (SIN), which signals through a chain of three kinases, including the terminal nuclear Dbf2-related (NDR) family kinase DBF2. Here, we provide evidence for the function of DBF2 during sexual development and vegetative growth of the homothallic ascomycetous model fungus Sordaria macrospora. Using mutants with a deleted dbf2 gene and

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13

Komarnitsky, Svetlana I., Yueh-Chin Chiang, Francis C. Luca, et al. "DBF2 Protein Kinase Binds to and Acts through the Cell Cycle-Regulated MOB1 Protein." Molecular and Cellular Biology 18, no. 4 (1998): 2100–2107. http://dx.doi.org/10.1128/mcb.18.4.2100.

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ABSTRACT The DBF2 gene of the budding yeast Saccharomyces cerevisiae encodes a cell cycle-regulated protein kinase that plays an important role in the telophase/G1 transition. As a component of the multisubunit CCR4 transcriptional complex, DBF2 is also involved in the regulation of gene expression. We have found that MOB1, an essential protein required for a late mitotic event in the cell cycle, genetically and physically interacts with DBF2. DBF2 binds MOB1 in vivo and can bind it in vitro in the absence of other yeast proteins. We found that the expression of MOB1 is also cell cycle regulat

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14

Toyn, J. H., and L. H. Johnston. "Spo12 is a limiting factor that interacts with the cell cycle protein kinases Dbf2 and Dbf20, which are involved in mitotic chromatid disjunction." Genetics 135, no. 4 (1993): 963–71. http://dx.doi.org/10.1093/genetics/135.4.963.

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Abstract The DBF2 and DBF20 genes of the budding yeast Saccharomyces cerevisiae encode a pair of structurally similar protein kinases. Although yeast with either gene deleted is viable, deletion of both genes is lethal. Thus, the Dbf2 and Dbf20 proteins are functional alternatives for an essential activity. In contrast to deletions, four different mutant alleles of DBF2 are lethal. Thus, the presence of a nonfunctional Dbf2 protein, rather than the lack of function per se, is inhibitory. Here we present genetic evidence that nonfunctional mutant Dbf2 protein blocks the function of Dbf20 protei

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15

Kitada, K., A. L. Johnson, L. H. Johnston, and A. Sugino. "A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5." Molecular and Cellular Biology 13, no. 7 (1993): 4445–57. http://dx.doi.org/10.1128/mcb.13.7.4445-4457.1993.

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We have isolated a multicopy suppressor of the temperature-sensitive growth phenotype of organisms carrying mutations of DBF4, a gene that is required for the initiation of chromosomal DNA replication in Saccharomyces cerevisiae and that interacts with the CDC7 protein kinase. Nucleotide sequence analysis of the suppressor gene, provisionally named MSD2, revealed an open reading frame encoding a protein with a calculated M(r) of 81,024, with amino acid sequence similarity to the catalytic domains of protein kinases. Both genetic linkage and complementation analyses indicated that MSD2 is ident

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16

Kitada, K., A. L. Johnson, L. H. Johnston, and A. Sugino. "A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5." Molecular and Cellular Biology 13, no. 7 (1993): 4445–57. http://dx.doi.org/10.1128/mcb.13.7.4445.

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Анотація:

We have isolated a multicopy suppressor of the temperature-sensitive growth phenotype of organisms carrying mutations of DBF4, a gene that is required for the initiation of chromosomal DNA replication in Saccharomyces cerevisiae and that interacts with the CDC7 protein kinase. Nucleotide sequence analysis of the suppressor gene, provisionally named MSD2, revealed an open reading frame encoding a protein with a calculated M(r) of 81,024, with amino acid sequence similarity to the catalytic domains of protein kinases. Both genetic linkage and complementation analyses indicated that MSD2 is ident

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17

Hafid, Zulham, Amiruddin Akbar Fisu, Windra Priatna Humang, and Rakhmawati Natsir. "Application of The PPP Scheme on The Tourism-Transportation, Case Study : The Concept Of Palopo City Tourism." PENA TEKNIK: Jurnal Ilmiah Ilmu-Ilmu Teknik 7, no. 1 (2022): 32. http://dx.doi.org/10.51557/pt_jiit.v7i1.1119.

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The stipulation of the Palopo City Regional Tourism Development Master Plan 2021 – 2025 makes the Palopo City tourism sector quite optimistic after the beginning of the pandemic. Until 2030, Palopo City targets 250,000 domestic tourists and 1800 foreign tourists. The tourism potential of Palopo City, especially in urban areas is quite promising with the construction of a culinary center and souvenirs, public space activities, and the development of culinary businesses. These potentials must be supported by adequate facilities and infrastructure, including accessibility. Meanwhile, public trans

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18

Visintin, Rosella, and Angelika Amon. "Regulation of the Mitotic Exit Protein Kinases Cdc15 and Dbf2." Molecular Biology of the Cell 12, no. 10 (2001): 2961–74. http://dx.doi.org/10.1091/mbc.12.10.2961.

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In budding yeast, the release of the protein phosphatase Cdc14 from its inhibitor Cfi1/Net1 in the nucleolus during anaphase triggers the inactivation of Clb CDKs that leads to exit from mitosis. The mitotic exit pathway controls the association between Cdc14 and Cfi1/Net1. It is comprised of the RAS-like GTP binding protein Tem1, the exchange factor Lte1, the GTPase activating protein complex Bub2-Bfa1/Byr4, and several protein kinases including Cdc15 and Dbf2. Here we investigate the regulation of the protein kinases Dbf2 and Cdc15. We find that Cdc15 is recruited to both spindle pole bodies

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19

Cassatt, David R., Nita K. Patel, Nancy D. Ulbrandt, and Mark S. Hanson. "DbpA, but Not OspA, Is Expressed by Borrelia burgdorferi during Spirochetemia and Is a Target for Protective Antibodies." Infection and Immunity 66, no. 11 (1998): 5379–87. http://dx.doi.org/10.1128/iai.66.11.5379-5387.1998.

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ABSTRACT DbpA is a target for antibodies that protect mice against infection by cultured Borrelia burgdorferi. Infected mice exhibit early and sustained humoral responses to DbpA and DbpB, suggesting that these proteins are expressed in vivo. Many antigens expressed in mammals by B. burgdorferi are repressed in vitro at lower growth temperatures, and we have now extended these observations to include DbpA and DbpB. To confirm that the protective antigen DbpA is expressed in vivo and to address the question of its accessibility to antibodies during infection, we examined B. burgdorferi in blood

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20

Roberts, William C., Brian A. Mullikin, Raju Lathigra, and Mark S. Hanson. "Molecular Analysis of Sequence Heterogeneity among Genes Encoding Decorin Binding Proteins A and B of Borrelia burgdorferi Sensu Lato." Infection and Immunity 66, no. 11 (1998): 5275–85. http://dx.doi.org/10.1128/iai.66.11.5275-5285.1998.

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ABSTRACT Immunization of mice with Borrelia burgdorferi decorin binding protein A (DbpA), one of two gene products of thedbpBA locus, has been shown recently to confer protection against challenge. Hyperimmune DbpA antiserum killed a large number of B. burgdorferi sensu lato isolates of diverse phylogeny and origin, suggesting conservation of the protective epitope(s). In order to evaluate the heterogeneity of DbpA and DbpB and to facilitate defining the conserved epitope(s) of these antigens, the sequences of the dbpA genes from 29 B. burgdorferi sensu lato isolates and of the dbpBgenes from

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21

Hanson, Mark S., David R. Cassatt, Betty P. Guo, et al. "Active and Passive Immunity against Borrelia burgdorferi Decorin Binding Protein A (DbpA) Protects against Infection." Infection and Immunity 66, no. 5 (1998): 2143–53. http://dx.doi.org/10.1128/iai.66.5.2143-2153.1998.

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ABSTRACT Borrelia burgdorferi, the spirochete that causes Lyme disease, binds decorin, a collagen-associated extracellular matrix proteoglycan found in the skin (the site of entry for the spirochete) and in many other tissues. Two borrelial adhesins that recognize this proteoglycan, decorin binding proteins A and B (DbpA and DbpB, respectively), have recently been identified. Infection of mice by low-dose B. burgdorferi challenge elicited antibodies against DbpA and DbpB that were sustained at high levels, suggesting that these antigens are expressed in vivo. Scanning immunoelectron microscopy

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22

Fortune, Danielle E., Yi-Pin Lin, Ranjit K. Deka, et al. "Identification of Lysine Residues in the Borrelia burgdorferi DbpA Adhesin Required for Murine Infection." Infection and Immunity 82, no. 8 (2014): 3186–98. http://dx.doi.org/10.1128/iai.02036-14.

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ABSTRACTDecorin-binding protein A (DbpA) ofBorrelia burgdorferimediates bacterial adhesion to heparin and dermatan sulfate associated with decorin. Lysines K82, K163, and K170 of DbpA are known to be important forin vitrointeraction with decorin, and the DbpA structure, initially solved by nuclear magnetic resonance (NMR) spectroscopy, suggests these lysine residues colocalize in a pocket near the C terminus of the protein. In the current study, we solved the structure of DbpA fromB. burgdorferistrain 297 using X-ray crystallography and confirmed the existing NMR structural data.In vitrobindin

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23

Frenz, L. M., S. E. Lee, D. Fesquet, and L. H. Johnston. "The budding yeast Dbf2 protein kinase localises to the centrosome and moves to the bud neck in late mitosis." Journal of Cell Science 113, no. 19 (2000): 3399–408. http://dx.doi.org/10.1242/jcs.113.19.3399.

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Dbf2 is a multifunctional protein kinase in Saccharomyces cerevisiae that functions in transcription, the stress response and as part of a network of genes in exit from mitosis. By analogy with fission yeast it seemed likely that these mitotic exit genes would be involved in cytokinesis. As a preliminary investigation of this we have used Dbf2 tagged with GFP to examine intracellular localisation of the protein in living cells. Dbf2 is found on the centrosomes/spindle pole bodies (SPBs) and also at the bud neck where it forms a double ring. The localisation of Dbf2 is cell cycle regulated. It

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24

Hagman, Kayla E., Xiaofeng Yang, Stephen K. Wikel, et al. "Decorin-Binding Protein A (DbpA) of Borrelia burgdorferi Is Not Protective When Immunized Mice Are Challenged via Tick Infestation and Correlates with the Lack of DbpA Expression by B. burgdorferi in Ticks." Infection and Immunity 68, no. 8 (2000): 4759–64. http://dx.doi.org/10.1128/iai.68.8.4759-4764.2000.

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ABSTRACT Previous studies showed that decorin-binding protein A (DbpA) ofBorrelia burgdorferi was a protective immunogen in the murine model of Lyme borreliosis when mice were challenged (needle inoculated) intradermally with in vitro-cultivated spirochetes. In the present study, DbpA-immunized C3H/HeJ mice were not protected from infection when infested with Ixodes scapularis nymphs harboring virulent B. burgdorferi 297. This lack of protection correlated with the failure to detect DbpA on B. burgdorferi in ticks, suggesting that DbpA is not available as a target for bactericidal antibodies i

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25

Zhang, Yi-zhi, Qiu-hui Chen, Zhan-chuan Liu, Ying Zhang, Yan-qiu Han, and Shan-ji Nan. "Dissecting basilar artery aneurysm manifesting as sudden sensorineural hearing loss: a case report and literature review." Journal of International Medical Research 47, no. 11 (2019): 5844–48. http://dx.doi.org/10.1177/0300060519875374.

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Highlights • Dissecting basilar artery aneurysm (DBAA) is relatively rare. • We report the first case of a DBAA manifesting as sudden sensorineural hearing loss. • This case report adds to the symptom spectrum of DBAA.

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26

Morgan, Ashli M., and Xu Wang. "Structural mechanisms underlying sequence-dependent variations in GAG affinities of decorin binding protein A, a Borrelia burgdorferi adhesin." Biochemical Journal 467, no. 3 (2015): 439–51. http://dx.doi.org/10.1042/bj20141201.

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Decorin-binding protein A (DBPA) is an important surface adhesin of the bacterium Borrelia burgdorferi, the causative agent of Lyme disease. DBPA facilitates the bacteria's colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide. Interestingly, DBPA sequence variation among different strains of Borrelia spirochetes is high, resulting in significant differences in their GAG affinities. However, the structural mechanisms contributing to these differences are unknown. We determined the solution structures of DBPAs from strain N40 of B. burgdorferi and strain

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27

Wurm, Jan Philip, Katarzyna-Anna Glowacz, and Remco Sprangers. "Structural basis for the activation of the DEAD-box RNA helicase DbpA by the nascent ribosome." Proceedings of the National Academy of Sciences 118, no. 35 (2021): e2105961118. http://dx.doi.org/10.1073/pnas.2105961118.

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The adenosine triphosphate (ATP)-dependent DEAD-box RNA helicase DbpA from Escherichia coli functions in ribosome biogenesis. DbpA is targeted to the nascent 50S subunit by an ancillary, carboxyl-terminal RNA recognition motif (RRM) that specifically binds to hairpin 92 (HP92) of the 23S ribosomal RNA (rRNA). The interaction between HP92 and the RRM is required for the helicase activity of the RecA-like core domains of DbpA. Here, we elucidate the structural basis by which DbpA activity is endorsed when the enzyme interacts with the maturing ribosome. We used nuclear magnetic resonance (NMR) s

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28

Kishimoto, Akihiro, Rong Zhou, and Tatsuya Imai. "Diverse Depth-First Search in Satisificing Planning." Proceedings of the International Symposium on Combinatorial Search 3, no. 1 (2021): 164–65. http://dx.doi.org/10.1609/socs.v3i1.18262.

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Diverse best-first search (DBFS) is a successful algorithm for satisficing planning that is built on top of greedy best-first search and uses stochastic search techniques to select the next ``best'' state that is not always in agreement with the heuristic function. DBFS thus considers a diversity of search directions and avoids search plateaus caused by inaccurate heuristic estimation. However, the scalability of DBFS is still limited by the available memory resource, as in any planning system that uses best-first search at its core. This paper presents the diverse depth-first search (DDFS) al

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29

Almawi, Ahmad, Lindsay Matthews, and Alba Guarné. "A novel method to stabilize weak protein complexes for crystallographic studies." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C320. http://dx.doi.org/10.1107/s205327331409679x.

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Most protein interactions mediating critical steps in cellular pathways are transient and, hence, are difficult to capture using structural approaches. An example from Saccharomyces cerevisiae is the interaction between checkpoint effector Rad53 kinase and replication initiation Dbf4-Cdc7 kinase. Dbf4 is the regulatory and Cdc7 the catalytic subunit of this kinase, which functions in activating replication origins. When a replication fork is damaged, the checkpoint response activates Rad53, which binds transiently, yet specifically, to Dbf4 and this, in turn, inhibits the activity of Dbf4-Cdc7

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Oldenburg, Darby G., Dean A. Jobe, Steven D. Lovrich, et al. "Detection of antibodies to decorin-binding protein A (DbpA) and DbpB after infection of dogs with Borrelia burgdorferi by tick challenge." Journal of Veterinary Diagnostic Investigation 32, no. 3 (2020): 481–85. http://dx.doi.org/10.1177/1040638720912394.

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We characterized the antibody response to decorin-binding protein A (DbpA) or DbpB from immune serum samples collected from 27 dogs infected with Borrelia burgdorferi by Ixodes scapularis ticks. Immunoglobulin M (IgM) antibodies to DbpA or DbpB were rarely detected, but high levels of IgG antibodies to DbpA were detected in 16 of 27 of the immune sera collected 1 mo after infection, 20 of 25 of the sera collected after 2 mo, and each of the 23, 17, or 11 serum samples evaluated after 3, 4, or 5 mo, respectively. In addition, IgG antibodies to DbpB were detected in 22 of 27 ( p = 0.005) tested

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31

Coelho, Igor M., Vitor N. Coelho, Rodolfo P. Araujo, Wang Yong Qiang, and Brett D. Rhodes. "Challenges of PBFT-Inspired Consensus for Blockchain and Enhancements over Neo dBFT." Future Internet 12, no. 8 (2020): 129. http://dx.doi.org/10.3390/fi12080129.

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Consensus mechanisms are a core feature for handling negotiation and agreements. Blockchain technology has seen the introduction of different sorts of consensus mechanism, ranging from tasks of heavy computation to the subtle mathematical proofs of Byzantine agreements. This paper presents the pioneer Delegated Byzantine Fault Tolerance (dBFT) protocol of Neo Blockchain, which was inspired by the Practical Byzantine Fault Tolerance (PBFT). Besides introducing its history, this study describes proofs and didactic examples, as well as novel design and extensions for Neo dBFT with multiple block

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Ortiz, Javier, Concepción Parejo, Federico Payá, Fernando Fernández-Lázaro, Larry Lüer, and Ángela Sastre-Santos. "Synthesis and optical properties of phthalocyanine-dihydrobenzocyclobutacenaphthylene systems." Journal of Porphyrins and Phthalocyanines 17, no. 10 (2013): 1008–15. http://dx.doi.org/10.1142/s1088424613500879.

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Four new zinc phthalocyanines (ZnPcs 1–4) peripherally substituted with fully conjugated 6b,10b-dihydrobenzo[j]cyclobut[a]acenaphthylene (DBCA) have been synthesized and chemically characterized. In ( DBCA )4 ZnPc 1 and t Bu 3( DBCA ) ZnPc 2 the DBCA units are directly connected to the phthalocyanine core, meanwhile in ( VDBCA )4 ZnPc 3 and t Bu 3( VDBCA ) ZnPc 4 DCBA units are connected through a vinyl spacer. We describe the effect of the substituents on optical spectra, fluorescence lifetimes and quantum yields.

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33

Imai, Denise M., D. Scott Samuels, Sunlian Feng, Emir Hodzic, Kim Olsen, and Stephen W. Barthold. "The Early Dissemination Defect Attributed to Disruption of Decorin-Binding Proteins Is Abolished in Chronic Murine Lyme Borreliosis." Infection and Immunity 81, no. 5 (2013): 1663–73. http://dx.doi.org/10.1128/iai.01359-12.

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ABSTRACTThe laboratory mouse model of Lyme disease has revealed thatBorrelia burgdorferidifferentially expresses numerous outer surface proteins that influence different stages of infection (tick-borne transmission, tissue colonization, dissemination, persistence, and tick acquisition). Deletion of two such outer surface proteins, decorin-binding proteins A and B (DbpA/B), has been documented to decrease infectivity, impede early dissemination, and, possibly, prevent persistence. In this study, DbpA/B-deficient spirochetes were confirmed to exhibit an early dissemination defect in immunocompet

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Jegadeeswari, S., P. Dinadayalan, and D. Gnanambigai. "Efficient Dynamic Bloom Filter Hashing Fragmentation for Cloud Data Storage." Cybernetics and Information Technologies 19, no. 1 (2019): 53–72. http://dx.doi.org/10.2478/cait-2019-0003.

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Abstract Security is important in cloud data storage while using the cloud services provided by the service provider in the cloud. Most of the research works have been designed for a secure cloud data storage. However, cloud users still have security issues with their outsourced data. In order to overcome such limitations, a Dynamic Bloom Filter Hashing based Cloud Data Storage (DBFH-CDS) Technique is proposed. The main goal of DBFH-CDS Technique is to improve confidentiality and security of data storage in a cloud environment. The proposed Technique is implemented using data fragmentation mod

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Taiwo, Rasheed Ayinde, Yeongil Son, Joonghan Shin, and Yusuff Adeyemi Salawu. "Enhanced Activation in Phosphorous-Doped Silicon via Dual-Beam Laser Annealing." Materials 17, no. 17 (2024): 4316. http://dx.doi.org/10.3390/ma17174316.

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In this study, we conduct a comparative analysis of single-beam laser annealing (SBLA) and dual-beam laser annealing (DBLA) techniques for semiconductor manufacturing. In the DBLA approach, two laser beams were precisely aligned to simultaneously heat a phosphorus-doped silicon (Si) wafer. The main objective was to investigate the impact of the two annealing techniques on the electrical properties, crystalline structure, and diffusion profile of the treated phosphorus-doped Si at equivalent laser powers. Both SBLA and DBLA improved the electrical properties of the phosphorus-doped Si, evidence

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Feng, Sunlian, Emir Hodzic, Brian Stevenson, and Stephen W. Barthold. "Humoral Immunity to Borrelia burgdorferiN40 Decorin Binding Proteins during Infection of Laboratory Mice." Infection and Immunity 66, no. 6 (1998): 2827–35. http://dx.doi.org/10.1128/iai.66.6.2827-2835.1998.

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ABSTRACT A Borrelia burgdorferi N40 genomic expression library was screened with serum from actively infected mice to identify gene products that elicit protective immunity. A clone that contained a putative bicistronic operon containing two genes that encoded 20- and 22-kDa lipoproteins was identified and sequenced. These genes showed homology with the genes encoding decorin binding proteins DbpB and DbpA, respectively, of B. burgdorferi 297 and B31.N40-dbpA DNA hybridized with B. burgdorferi N40 DNA on a single 48-kb linear plasmid. Homologous genes could be amplified under various degrees o

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Jiang, Mingli, Xingqiang Zou, Yumin Huang, and Xiaobo Liu. "The effect of bismaleimide on thermal, mechanical, and dielectric properties of allyl-functional bisphthalonitrile/bismaleimide system." High Performance Polymers 29, no. 9 (2016): 1016–26. http://dx.doi.org/10.1177/0954008316667788.

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Allyl-functional phthalonitrile (DBPA-Ph) and bismaleimide (BMI) have been considered as advanced composite-matrix resins applied in various fields. In this work, self-promoted polymerization behavior and processability of DBPA-Ph/BMI system were investigated in detail. To further reveal the effect of BMI on the properties of DBPA-Ph/BMI system, the blends and the prepolymers of DBPA-Ph/BMI were prepared in different proportions. Their curing and rheological behaviors were investigated by differential scanning calorimetry and dynamic rheological analysis. The results further confirmed the poss

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38

Shi, Yanlin, Qilong Xu, Kristy McShan, and Fang Ting Liang. "Both Decorin-Binding Proteins A and B Are Critical for the Overall Virulence of Borrelia burgdorferi." Infection and Immunity 76, no. 3 (2008): 1239–46. http://dx.doi.org/10.1128/iai.00897-07.

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ABSTRACT Both decorin-binding proteins (DbpA and DbpB) of the Lyme disease spirochete Borrelia burgdorferi bind decorin and glycosaminoglycans, two important building blocks of proteoglycans that are abundantly found in the extracellular matrix (ECM) and connective tissues as well as on cell surfaces of mammals. As an extracellular pathogen, B. burgdorferi resides primarily in the ECM and connective tissues and between host cells during mammalian infection. The interactions of B. burgdorferi with these host ligands mediated by DbpA and DbpB potentially influence various aspects of infection. H

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Bachant, Jeff, Elizabeth A. Hoffman, Chris Caridi, Constance I. Nugent, and Wenyi Feng. "The yeast Dbf4 Zn2+ finger domain suppresses single-stranded DNA at replication forks initiated from a subset of origins." Current Genetics 68, no. 2 (2022): 253–65. http://dx.doi.org/10.1007/s00294-022-01230-6.

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AbstractDbf4 is the cyclin-like subunit for the Dbf4-dependent protein kinase (DDK), required for activating the replicative helicase at DNA replication origin that fire during S phase. Dbf4 also functions as an adaptor, targeting the DDK to different groups of origins and substrates. Here we report a genome-wide analysis of origin firing in a budding yeast mutant, dbf4-zn, lacking the Zn2+ finger domain within the C-terminus of Dbf4. At one group of origins, which we call dromedaries, we observe an unanticipated DNA replication phenotype: accumulation of single-stranded DNA spanning ± 5kbp fr

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40

Hoppstock, Gregor, Jonathan A. Lindquist, Antonia Willems, et al. "DNA-Binding Protein A Is Actively Secreted in a Calcium-and Inflammasome-Dependent Manner and Negatively Influences Tubular Cell Survival." Cells 13, no. 20 (2024): 1742. http://dx.doi.org/10.3390/cells13201742.

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DNA-binding protein A (DbpA) belongs to the Y-box family of cold shock domain (CSD) proteins that bind RNA/DNA and exert intracellular functions in cell stress, proliferation, and differentiation. Given the pattern of DbpA staining in inflammatory glomerular diseases, without adherence to cell boundaries, we hypothesized extracellular protein occurrence and specific functions. Lipopolysaccharide and ionomycin induce DbpA expression and secretion from melanoma and mesangial cells. Unlike its homologue Y-box-binding protein 1 (YB-1), DbpA secretion requires inflammasome activation, as secretion

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41

Jackson, A. L., P. M. Pahl, K. Harrison, J. Rosamond, and R. A. Sclafani. "Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein." Molecular and Cellular Biology 13, no. 5 (1993): 2899–908. http://dx.doi.org/10.1128/mcb.13.5.2899-2908.1993.

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Yeast Cdc7 protein kinase and Dbf4 protein are both required for the initiation of DNA replication at the G1/S phase boundary of the mitotic cell cycle. Cdc7 kinase function is stage-specific in the cell cycle, but total Cdc7 protein levels remained unchanged. Therefore, regulation of Cdc7 function appears to be the result of posttranslational modification. In this study, we have attempted to elucidate the mechanism responsible for achieving this specific execution point of Cdc7. Cdc7 kinase activity was shown to be maximal at the G1/S boundary by using either cultures synchronized with alpha

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42

Jackson, A. L., P. M. Pahl, K. Harrison, J. Rosamond, and R. A. Sclafani. "Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein." Molecular and Cellular Biology 13, no. 5 (1993): 2899–908. http://dx.doi.org/10.1128/mcb.13.5.2899.

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Анотація:

Yeast Cdc7 protein kinase and Dbf4 protein are both required for the initiation of DNA replication at the G1/S phase boundary of the mitotic cell cycle. Cdc7 kinase function is stage-specific in the cell cycle, but total Cdc7 protein levels remained unchanged. Therefore, regulation of Cdc7 function appears to be the result of posttranslational modification. In this study, we have attempted to elucidate the mechanism responsible for achieving this specific execution point of Cdc7. Cdc7 kinase activity was shown to be maximal at the G1/S boundary by using either cultures synchronized with alpha

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43

Benoit, Vivian M., Joshua R. Fischer, Yi-Pin Lin, Nikhat Parveen, and John M. Leong. "Allelic Variation of the Lyme Disease Spirochete Adhesin DbpA Influences Spirochetal Binding to Decorin, Dermatan Sulfate, and Mammalian Cells." Infection and Immunity 79, no. 9 (2011): 3501–9. http://dx.doi.org/10.1128/iai.00163-11.

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ABSTRACTAfter transmission by an infected tick, the Lyme disease spirochete,Borrelia burgdorferisensu lato, colonizes the mammalian skin and may disseminate systemically. The three major species of Lyme disease spirochete—B. burgdorferisensu stricto,B. garinii, andB. afzelii—are associated with different chronic disease manifestations. Colonization is likely promoted by the ability to bind to target tissues, and Lyme disease spirochetes utilize multiple adhesive molecules to interact with diverse mammalian components. The allelic variable surface lipoprotein decorin binding protein A (DbpA) pr

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44

Lindquist, Jonathan A., Anja Bernhardt, Charlotte Reichardt, et al. "Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease." Cells 12, no. 10 (2023): 1426. http://dx.doi.org/10.3390/cells12101426.

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DNA-binding protein A (DbpA) belongs to the Y-box family of cold shock domain proteins that exert transcriptional and translational activities in the cell via their ability to bind and regulate mRNA. To investigate the role of DbpA in kidney disease, we utilized the murine unilateral ureter obstruction (UUO) model, which recapitulates many features of obstructive nephropathy seen in humans. We observed that DbpA protein expression is induced within the renal interstitium following disease induction. Compared with wild-type animals, obstructed kidneys from Ybx3-deficient mice are protected from

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45

Xu, Qilong, Sunita V. Seemanaplli, Kristy McShan, and Fang Ting Liang. "Increasing the Interaction of Borrelia burgdorferi with Decorin Significantly Reduces the 50 Percent Infectious Dose and Severely Impairs Dissemination." Infection and Immunity 75, no. 9 (2007): 4272–81. http://dx.doi.org/10.1128/iai.00560-07.

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ABSTRACT Tight regulation of surface antigenic expression is crucial for the pathogenic strategy of the Lyme disease spirochete, Borrelia burgdorferi. Here, we report the influence of increasing expression of decorin-binding protein A (DbpA), one of the most investigated spirochetal surface adhesins, on the 50% infectious dose (ID50), dissemination, tissue colonization, pathogenicity, and persistence of B. burgdorferi in the murine host. Our in vitro assays showed that increasing DbpA expression dramatically increased the interaction of B. burgdorferi with decorin and sensitivity to growth inh

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46

Ruggiero, G. A., Y. Ourmières, E. Cosme, J. Blum, D. Auroux, and J. Verron. "Data assimilation experiments using diffusive back-and-forth nudging for the NEMO ocean model." Nonlinear Processes in Geophysics 22, no. 2 (2015): 233–48. http://dx.doi.org/10.5194/npg-22-233-2015.

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Abstract. The diffusive back-and-forth nudging (DBFN) is an easy-to-implement iterative data assimilation method based on the well-known nudging method. It consists of a sequence of forward and backward model integrations, within a given time window, both of them using a feedback term to the observations. Therefore, in the DBFN, the nudging asymptotic behaviour is translated into an infinite number of iterations within a bounded time domain. In this method, the backward integration is carried out thanks to what is called backward model, which is basically the forward model with reversed time s

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47

Tantely, Andriamampianina Tianarilalaina, Randrianavony Patricia, Rasoanaivo Herilala Lea та Pr Randimbivololona Fanantenanirainy. "Inhibition Of TNF-α Release by D : B- Friedo - Olean -5- En- 3α -Ol in Human Monocytes". European Scientific Journal, ESJ 12, № 30 (2016): 166. http://dx.doi.org/10.19044/esj.2016.v12n30p166.

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This study was focused on the release of TNF- α by cultured monocytes of human blood in the absence and presence of D : B Friedo - olean - 5 -en- 3α -ol (DBFO). The human monocytes were isolated from the peripheral blood mononuclear cells (PBMC). The release of TNF-α by monocytes was induced by the addition of lipopolysaccharide (LPS) to the culture medium. ELISA Sandwich's method was used to the dosing of TNF- α concentration. The release of TNF-α is inhibited by DBFO. In the absence of DBFO, TNF- α concentration is 3.86 ng/ml versus 3.77 ; 3.2 ; 2.79 and 0.89 ng/ml in the presence of DBFO at

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48

Balasundaram, Arthi. "Comparison of DBFS with MoCA and MMSE tools for MCI screening." Bioinformation 19, no. 5 (2023): 522–24. http://dx.doi.org/10.6026/97320630019522.

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Mild cognitive impairment (MCI) has been associated with many diseases. The MCI could be a marker for the early diagnosis of certain diseases. Early detection of MCI could be beneficial for restoration of cognitive reserves. One hundred and five subjects were included in the study, underwent the Digital Brain Function Screen (DBFS) test as well as the Montreal Cognitive Assessment (MoCA) test and 73 subjects took the Mini-Mental State Examination (MMSE) test. DBFS test and retest was taken by 16 subjects. The test scores of DBFS tool showed significant positive correlation with MoCA and MMSE t

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49

Li, Xiran, Muxing Liu, Olivia L. Hajek, and Guodong Yin. "Different Temporal Stability and Responses to Droughts between Needleleaf Forests and Broadleaf Forests in North China during 2001–2018." Forests 12, no. 10 (2021): 1331. http://dx.doi.org/10.3390/f12101331.

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Droughts can affect the physiological activity of trees, damage tissues, and even trigger mortality, yet the response of different forest types to drought at the decadal time scale remains uncertain. In this study, we used two remote sensing-based vegetation products, the MODIS enhanced vegetation index (EVI) and MODIS gross primary productivity (GPP), to explore the temporal stability of deciduous needleleaf forests (DNFs) and deciduous broadleaf forests (DBFs) in droughts and their legacy effects in North China from 2001 to 2018. The results of both products showed that the temporal stabilit

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50

Sato, Yukari, Marta Monincová, Radka Chaloupková, et al. "Two Rhizobial Strains, Mesorhizobium loti MAFF303099 and Bradyrhizobium japonicum USDA110, Encode Haloalkane Dehalogenases with Novel Structures and Substrate Specificities." Applied and Environmental Microbiology 71, no. 8 (2005): 4372–79. http://dx.doi.org/10.1128/aem.71.8.4372-4379.2005.

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ABSTRACT Haloalkane dehalogenases are key enzymes for the degradation of halogenated aliphatic pollutants. Two rhizobial strains, Mesorhizobium loti MAFF303099 and Bradyrhizobium japonicum USDA110, have open reading frames (ORFs), mlr5434 and blr1087, respectively, that encode putative haloalkane dehalogenase homologues. The crude extracts of Escherichia coli strains expressing mlr5434 and blr1087 showed the ability to dehalogenate 18 halogenated compounds, indicating that these ORFs indeed encode haloalkane dehalogenases. Therefore, these ORFs were referred to as dmlA (dehalogenase from Mesor

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