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Статті в журналах з теми "Denticola"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Brissette, Catherine A., та Sheila A. Lukehart. "Mechanisms of Decreased Susceptibility to β-Defensins by Treponema denticola". Infection and Immunity 75, № 5 (2007): 2307–15. http://dx.doi.org/10.1128/iai.01718-06.

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ABSTRACT Treponema denticola, a periodontal pathogen, is relatively resistant to human beta-defensins, which are small cationic antimicrobial peptides produced by a number of cells, including the gingival epithelium. Using two independent methods, we previously demonstrated that T. denticola proteases are not responsible for decreased vulnerability to defensins. In this study, we confirmed that the major outer membrane protease, dentilisin, is not responsible for T. denticola insensitivity to defensins and examined several other possible mechanisms, including reduced binding to the bacterial s

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2

Kurniyati, Kurni, and Chunhao Li. "pyrFas a Counterselectable Marker for Unmarked Genetic Manipulations in Treponema denticola." Applied and Environmental Microbiology 82, no. 4 (2015): 1346–52. http://dx.doi.org/10.1128/aem.03704-15.

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ABSTRACTThe pathophysiology ofTreponema denticola, an oral pathogen associated with both periodontal and endodontic infections, is poorly understood due to its fastidious growth and recalcitrance to genetic manipulations. Counterselectable markers are instrumental in constructing clean and unmarked mutations in bacteria. Here, we demonstrate thatpyrF, a gene encoding orotidine-5′-monophosphate decarboxylase, can be used as a counterselectable marker inT. denticolato construct marker-free mutants.T. denticolais susceptible to 5-fluoroorotic acid (5-FOA). To establish apyrF-based counterselectab

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3

Yang, Po Fong, Meja Song, David A. Grove, and Richard P. Ellen. "Filamentous Actin Disruption and Diminished Inositol Phosphate Response in Gingival Fibroblasts Caused byTreponema denticola." Infection and Immunity 66, no. 2 (1998): 696–702. http://dx.doi.org/10.1128/iai.66.2.696-702.1998.

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ABSTRACT Previous reports have shown that Treponema denticolacauses rearrangement of filamentous actin (F-actin) in human gingival fibroblasts (HGF). The purpose of this investigation was to determine the effect of T. denticola on the generation of inositol phosphates (IPs) in relation to a time course for F-actin disruption in HGF. Cultured HGF were exposed to washed cells of T. denticola ATCC 35405 for 140 min. Changes in the fluorescence intensity of rhodamine-phalloidin-labeled F-actin in serial optical sections of single HGF were quantified by confocal microscopy image analysis. The perce

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4

Battikhi, Tulin, Wilson Lee, Christopher A. G. McCulloch, and Richard P. Ellen. "Treponema denticola Outer Membrane Enhances the Phagocytosis of Collagen-Coated Beads by Gingival Fibroblasts." Infection and Immunity 67, no. 3 (1999): 1220–26. http://dx.doi.org/10.1128/iai.67.3.1220-1226.1999.

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ABSTRACT Human gingival fibroblasts (HGFs) degrade collagen fibrils in physiological processes by phagocytosis. Since Treponema denticola outer membrane (OM) extract perturbs actin filaments, important structures in phagocytosis, we determined whether the OM affects collagen phagocytosis in vitro by HGFs. Phagocytosis was measured by flow cytometric assessment of internalized collagen-coated fluorescent latex beads. Confluent HGFs pretreated with T. denticola ATCC 35405 OM exhibited an increase in the percentage of collagen phagocytic cells (phagocytosis index [PI]) and in the number of beads

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5

Idrus, Erik, Willy Hartanto, Widya Lestari, and Dewi Fatma Suniarti. "The role of Treponema denticola in the periodontitis alveolar bone damage: Systematic review." Odonto : Dental Journal 10, no. 2 (2023): 314. http://dx.doi.org/10.30659/odj.10.2.314-325.

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Background: Periodontitis is a chronic inflammation condition of the periodontal tissue, which causes irreversible, progressive deterioration of the tooth-supporting tissue, leading to tooth loss. One of the main bacteria in the pathogenesis of periodontitis is Treponema denticola. Its involvement in periodontitis includes producing and releasing various virulence factors that further modulate inflammation and ignite alveolar bone destruction. Objective: To examine Treponema denticola's role in the mechanism of alveolar bone damage in periodontitis. Method: This systematic review was conducted

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6

Brissette, Catherine A., та Sheila A. Lukehart. "Treponema denticola Is Resistant to Human β-Defensins". Infection and Immunity 70, № 7 (2002): 3982–84. http://dx.doi.org/10.1128/iai.70.7.3982-3984.2002.

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ABSTRACT Spirochetes, including Treponema denticola, are implicated in the pathogenesis of periodontal disease. Because T. denticola lacks lipopolysaccharides that serve as targets for human β-defensin (hβD) binding, we postulated that T. denticola would resist killing by hβD. We showed that T. denticola is resistant to hβD-1 and -2. Protease inhibitors did not enhance killing of T. denticola by hβD-2, suggesting that degradation of hβD-2 by treponemal proteases is not a major factor in T. denticola resistance.

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7

Chi, Bo, Ronald J. Limberger, and Howard K. Kuramitsu. "Complementation of a Treponema denticola flgE Mutant with a Novel Coumermycin A1-Resistant T. denticola Shuttle Vector System." Infection and Immunity 70, no. 4 (2002): 2233–37. http://dx.doi.org/10.1128/iai.70.4.2233-2237.2002.

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ABSTRACT By using the mutated gyrB gene from a spontaneous coumermycin A1-resistant Treponema denticola, an Escherichia coli-T. denticola shuttle vector that renders T. denticola resistant to coumermycin was constructed. The complete T. denticola flgE gene was cloned into the shuttle vector pKMCou, and the vector was transformed into the T. denticola ATCC 33520 flgE erythromycin-resistant knockout mutant HL210. The coumermycin-resistant transformants were motile and restored FlgE activity. This complementation system should prove useful in studying the virulence factors of T. denticola and unc

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8

Vesey, Peter M., and Howard K. Kuramitsu. "Genetic analysis of Treponema denticola ATCC 35405 biofilm formation." Microbiology 150, no. 7 (2004): 2401–7. http://dx.doi.org/10.1099/mic.0.26816-0.

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Treponema denticola is a major aetiological organism implicated in periodontal disease. The interaction of T. denticola with other oral bacteria, in particular Porphyromonas gingivalis, in biofilm formation is thought to be an important step in the onset of periodontal disease. The interaction between T. denticola and P. gingivalis has been examined using a panel of T. denticola mutants and their effects on mixed biofilm formation tested in a static biofilm model. T. denticola ATCC 35405 did not form detectable biofilms on various inert surfaces. However, the spirochaete was demonstrated to fo

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9

Wu, Linrui, Xinyi Su, Zhiqun Tang та ін. "Treponema denticola Induces Neuronal Apoptosis by Promoting Amyloid-β Accumulation in Mice". Pathogens 11, № 10 (2022): 1150. http://dx.doi.org/10.3390/pathogens11101150.

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Background: Neuronal apoptosis is a major contributor to Alzheimer’s disease (AD). Periodontitis is a significant risk factor for AD. The periodontal pathogens Porphyromonas gingivalis and Treponema denticola have been shown to initiate the hallmark pathologies and behavioral symptoms of AD. Studies have found that T. denticola infection induced Tau hyperphosphorylation and amyloid β accumulation in the hippocampi of mice. Aβ accumulation is closely associated with neuronal apoptosis. However, the roles of T. denticola in neuronal apoptosis remain unclear and its roles in AD pathology need fur

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10

Shin, Ji Eun, Young Sook Kim, Ju-Eun Oh, Byung-Moo Min та Youngnim Choi. "Treponema denticola Suppresses Expression of Human β-Defensin-3 in Gingival Epithelial Cells through Inhibition of the Toll-Like Receptor 2 Axis". Infection and Immunity 78, № 2 (2009): 672–79. http://dx.doi.org/10.1128/iai.00808-09.

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ABSTRACT We reported previously that Treponema denticola, one of the periodontal pathogens, suppresses the expression of human β-defensins (HBDs) in human gingival epithelial cells. To identify the mechanisms involved in this suppression, immortalized and normal human gingival epithelial cells were infected with live or heat-killed T. denticola for 24 h, and then the expression of HBDs was examined by real-time RT-PCR. Live T. denticola suppressed the expression of HBD-3 substantially and also suppressed the expression of HBD-1 and HBD-2. However, heat-killed bacteria did not produce a suppres

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11

Nussbaum, Gabriel, Shimon Ben-Adi, Tamar Genzler, Michael Sela, and Graciela Rosen. "Involvement of Toll-Like Receptors 2 and 4 in the Innate Immune Response to Treponema denticola and Its Outer Sheath Components." Infection and Immunity 77, no. 9 (2009): 3939–47. http://dx.doi.org/10.1128/iai.00488-09.

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ABSTRACT Treponema denticola is considered an important oral pathogen in the development and progression of periodontal diseases. In the present study, the mechanisms of recognition and activation of murine macrophages by T. denticola and its major outer sheath protein (MSP) and lipooligosaccharide (LOS or glycolipid) were investigated. T. denticola cells and the MSP induced innate immune responses through TLR2-MyD88, whereas LOS induced a macrophage response through TLR4-MyD88. The presence of gamma interferon (IFN-γ), or of high numbers of T. denticola, circumvented the requirement for TLR2

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12

Kaliamoorthy, Sriram. "EXPLORING THE PRESENCE OF TREPONEMA DENTICOLA IN ORAL SQUAMOUS CELL CARCINOMA." Journal of Medical pharmaceutical and allied sciences 10, no. 5 (2021): 3686–88. http://dx.doi.org/10.22270/jmpas.v10i5.1679.

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Treponema denticola is a spirochete associated with periodontitis, an infectious disease that destroys tooth attachments. It appears that these organisms reach oral epithelial cells, where they undergo their own unique molecular mechanism before displaying the acquired phenotypes associated with cancer, including inhibition of apoptosis, proliferation, and increased migration of epithelial cells. With this background the objective is to study the presence of Treponema denticola in oral squamous cell carcinoma. Total of 30 oral squamous cell carcinoma and oral mucosal non-cancerous tissue speci

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13

Choi, Bong-Kyu, Hyun Jung Lee, Jung Hwa Kang, Gook Jin Jeong, Cheon Ki Min, and Yun-Jung Yoo. "Induction of Osteoclastogenesis and Matrix Metalloproteinase Expression by the Lipooligosaccharide of Treponema denticola." Infection and Immunity 71, no. 1 (2003): 226–33. http://dx.doi.org/10.1128/iai.71.1.226-233.2003.

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ABSTRACT Alveolar bone destruction is a characteristic feature of periodontitis. Treponema denticola is known to be involved in periodontitis. To elucidate the role of T. denticola in alveolar bone destruction in periodontitis, the effects of lipooligosaccharide (LOS) from T. denticola on osteoclast formation and on expression of osteoclast differentiation factor (ODF) and osteoprotegerin (OPG) mRNAs were examined in a coculture system by using mouse calvaria and bone marrow cells. In addition, the effect of T. denticola LOS on expression of matrix metalloproteinases (MMPs), which are involved

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14

Susanto, Chandra, Steven Wijaya, Ramayani Efendi, and Ridha Mahrani. "Efektivitas Antibakteri Hidrogel Lidah Buaya pada Treponema denticola dan Tannerela forsythia Bakteri: In Vitro." Jurnal Ilmiah Kesehatan Sandi Husada 10, no. 1 (2021): 259–66. http://dx.doi.org/10.35816/jiskh.v10i1.601.

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Pendahuluan; bakteri Treponema denticola dan Tannerela forsythia sebagai penyebab utama penyakit periodontal. Tujuan mengetahui efektivitas hidrogel aloe vera konsentrasi antibakteri 2,5%, 5%, 10%, dan 20% terhadap bakteri Treponema denticola dan Tannerela forsythia: in vitro. Metode; merupakan penelitian eksperimental laboratoris dengan desain post-test-only control group in vitro. Sampel penelitian adalah Treponema denticola dan Tannerela Forsythia. Pengumpulan data dengan mengukur diameter zona hambat menggunakan kaliper geser. Data dianalisis menggunakan ANOVA satu arah dan LSD. Hasil; men

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15

Ruby, John, Kunal Rehani, and Michael Martin. "Treponema denticola Activates Mitogen-Activated Protein Kinase Signal Pathways through Toll-Like Receptor 2." Infection and Immunity 75, no. 12 (2007): 5763–68. http://dx.doi.org/10.1128/iai.01117-07.

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ABSTRACT Treponema denticola, a spirochete indigenous to the oral cavity, is associated with host inflammatory responses to anaerobic polymicrobial infections of the root canal, periodontium, and alveolar bone. However, the cellular mechanisms responsible for the recognition of T. denticola by the innate immune system and the underlying cell signaling pathways that regulate the inflammatory response to T. denticola are currently unresolved. In this study, we demonstrate that T. denticola induces innate immune responses via the utilization of Toll-like receptor 2 (TLR2) but not TLR4. Assessment

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16

Foschi, F., J. Izard, H. Sasaki, et al. "Treponema denticola in Disseminating Endodontic Infections." Journal of Dental Research 85, no. 8 (2006): 761–65. http://dx.doi.org/10.1177/154405910608500814.

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Treponema denticola is a consensus periodontal pathogen that has recently been associated with endodontic pathology. In this study, the effect of mono-infection of the dental pulp with T. denticola and with polymicrobial "red-complex" organisms (RC) ( Porphyromonas gingivalis, Tannerella forsythia, and T. denticola) in inducing disseminating infections in wild-type (WT) and severe-combined-immunodeficiency (SCID) mice was analyzed. After 21 days, a high incidence (5/10) of orofacial abscesses was observed in SCID mice mono-infected with T. denticola, whereas abscesses were rare in SCID mice in

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17

Lee, Song F., Elisoa Andrian, Elden Rowland, and Ignacio Christian Marquez. "Immune Response and Alveolar Bone Resorption in a Mouse Model of Treponema denticola Infection." Infection and Immunity 77, no. 2 (2008): 694–98. http://dx.doi.org/10.1128/iai.01004-08.

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ABSTRACT Treponema denticola is considered to be an agent strongly associated with periodontal disease. The lack of an animal infection model has hampered the understanding of T. denticola pathogenesis and the host's immune response to infection. In this study, we have established an oral infection model in mice, demonstrating that infection by oral inoculation is feasible. The presence of T. denticola in the oral cavities of the animals was confirmed by PCR. Mice given T. denticola developed a specific immune response to the bacterium. The antibodies generated from the infection were mainly o

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18

Mitchell, Helen L., Stuart G. Dashper, Deanne V. Catmull, et al. "Treponema denticola biofilm-induced expression of a bacteriophage, toxin–antitoxin systems and transposases." Microbiology 156, no. 3 (2010): 774–88. http://dx.doi.org/10.1099/mic.0.033654-0.

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Treponema denticola is an oral spirochaete that has been strongly associated with chronic periodontitis. The bacterium exists as part of a dense biofilm (subgingival dental plaque) accreted to the tooth. To determine T. denticola gene products important for persistence as a biofilm we developed a continuous-culture biofilm model and conducted a genome-wide transcriptomic analysis of biofilm and planktonic cells. A total of 126 genes were differentially expressed with a fold change of 1.5 or greater. This analysis identified the upregulation of putative prophage genes in the T. denticola 35405

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19

RÔÇAS, Isabela das Neves, José Freitas SIQUEIRA Jr., Amauri FAVIERI, and Kátia Regina dos SANTOS. "Detecção de Treponema denticola em casos de abscesso perirradicular agudo." Pesquisa Odontológica Brasileira 14, no. 3 (2000): 209–12. http://dx.doi.org/10.1590/s1517-74912000000300004.

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Nosso objetivo foi detectar Treponema denticola em casos de abscesso perirradicular agudo. O DNA extraído das amostras de pus foi examinado pelo método da "Polymerase Chain Reaction" direcionada para o gene do RNAr (fração 16S). A amplificação usando o "primer" da espécie Treponema denticola permitiu detectá-la em 5 dos 6 casos de abscessos examinados. Apenas uma banda de tamanho esperado foi observada para as amostras positivas para esta bactéria, o que foi confirmado pela comparação com o DNA de referência do Treponema denticola (controle positivo). Até o momento, este é o primeiro relato da

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20

Santos, Pâmela Beatriz do Rosário Estevam dos, Patrícia Michelle Nagai de Lima, Ana Luiza do Rosário Palma, et al. "Review- The periodontal pathogen Treponema denticola: an atherosclerosis risk factor." Research, Society and Development 10, no. 1 (2021): e25810111637. http://dx.doi.org/10.33448/rsd-v10i1.11637.

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Objective: Treponema denticola “T. denticola” is a pathogen associated with periodontal diseases that exhibits capacity for adherence, invasion, and colonization of host tissues, which allows alternating its location and damage in different sites of human body. This review aimed to discuss different studies that detected T. denticola in atherosclerotic plaques, demonstrating the importance of periodontal disease on the systemic health and the necessity of exploring the outcome of this colonization apart from the oral cavity. Methodology: Fifty-five studies were identified and gathered in this

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21

Fenno, J. Christopher, Si Young Lee, Christopher H. Bayer, and Yu Ning. "The opdB Locus Encodes the Trypsin-Like Peptidase Activity of Treponema denticola." Infection and Immunity 69, no. 10 (2001): 6193–200. http://dx.doi.org/10.1128/iai.69.10.6193-6200.2001.

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ABSTRACT High levels of Treponema denticola in subgingival dental plaque are associated with severe periodontal disease.T. denticola, along with Porphyromonas gingivalis and Bacteroides forsythus, are the only cultivatable oral microorganisms that produce significant amounts of “trypsin-like” peptidase activity. The ability of subgingival plaque to hydrolyzeN-α-benzoyl-dl-arginine-2-naphthylamide (BANA) is associated with high levels of one or more of these organisms. The purpose of this study was to identify the gene encoding trypsin-like activity in T. denticola and thus facilitate molecular

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22

Godovikova, Valentina, M. Paula Goetting-Minesky, Jae M. Shin, Yvonne L. Kapila, Alexander H. Rickard, and J. Christopher Fenno. "A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405." Applied and Environmental Microbiology 81, no. 18 (2015): 6496–504. http://dx.doi.org/10.1128/aem.01541-15.

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ABSTRACTOral pathogens, includingTreponema denticola, initiate the dysregulation of tissue homeostasis that characterizes periodontitis. However, progress of research on the roles ofT. denticolain microbe-host interactions and signaling, microbial communities, microbial physiology, and molecular evolution has been hampered by limitations in genetic methodologies. This is typified by an extremely low transformation efficiency and inability to transform the most widely studiedT. denticolastrain with shuttle plasmids. Previous studies have suggested that robust restriction-modification (R-M) syst

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23

Ikegami, Akihiko, Kiyonobu Honma, Ashu Sharma, and Howard K. Kuramitsu. "Multiple Functions of the Leucine-Rich Repeat Protein LrrA of Treponema denticola." Infection and Immunity 72, no. 8 (2004): 4619–27. http://dx.doi.org/10.1128/iai.72.8.4619-4627.2004.

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ABSTRACT The gene lrrA, encoding a leucine-rich repeat protein, LrrA, that contains eight consensus tandem repeats of 23 amino acid residues, has been identified in Treponema denticola ATCC 35405. A leucine-rich repeat is a generally useful protein-binding motif, and proteins containing this repeat are typically involved in protein-protein interactions. Southern blot analysis demonstrated that T. denticola ATCC 35405 expresses the lrrA gene, but the gene was not identified in T. denticola ATCC 33520. In order to analyze the functions of LrrA in T. denticola, an lrrA-inactivated mutant of strai

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24

Sela, Michael N. "Role of Treponema Denticola in Periodontal Diseases." Critical Reviews in Oral Biology & Medicine 12, no. 5 (2001): 399–413. http://dx.doi.org/10.1177/10454411010120050301.

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Among periodontal anaerobic pathogens, the oral spirochetes, and especially Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis. Basic research as well as clinical evidence suggest that the prevalence of T. denticola, together with other proteolytic Gram-negative bacteria in high numbers in periodontal pockets, may play an important role in the progression of periodontal disease. The accumulation of these bacteria and their products in the pocket may render the surface lining periodont

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25

Ganther, Sean, Allan Radaic, Erin Malone, et al. "Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells." PLOS Pathogens 17, no. 7 (2021): e1009311. http://dx.doi.org/10.1371/journal.ppat.1009311.

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Periodontal disease is driven by dysbiosis in the oral microbiome, resulting in over-representation of species that induce the release of pro-inflammatory cytokines, chemokines, and tissue-remodeling matrix metalloproteinases (MMPs) in the periodontium. These chronic tissue-destructive inflammatory responses result in gradual loss of tooth-supporting alveolar bone. The oral spirochete Treponema denticola, is consistently found at significantly elevated levels in periodontal lesions. Host-expressed Toll-Like Receptor 2 (TLR2) senses a variety of bacterial ligands, including acylated lipopolysac

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26

Wyss, C., A. Moter, B. K. Choi, et al. "Treponema putidum sp. nov., a medium-sized proteolytic spirochaete isolated from lesions of human periodontitis and acute necrotizing ulcerative gingivitis." International Journal of Systematic and Evolutionary Microbiology 54, no. 4 (2004): 1117–22. http://dx.doi.org/10.1099/ijs.0.02806-0.

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So far, little phenotypic heterogeneity has been detected in cultured oral treponemes with trypsin-like proteolytic activity, and all have been assigned to the species Treponema denticola. However, comparisons of protein patterns and antigen expression in our collection of proteolytic oral treponemes occasionally identified isolates with a unique phenotype; e.g. strain OMZ 830 (=ATCC 700768), which qualified as a ‘pathogen-related oral spirochaete’ due to the presence of a ∼37 kDa protein reactive with the Treponema pallidum FlaA-specific mAb H9-2. In addition to such single isolates, a homoge

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27

Bamford, Caroline V., J. Christopher Fenno, Howard F. Jenkinson, and David Dymock. "The Chymotrypsin-Like Protease Complex of Treponema denticola ATCC 35405 Mediates Fibrinogen Adherence and Degradation." Infection and Immunity 75, no. 9 (2007): 4364–72. http://dx.doi.org/10.1128/iai.00258-07.

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ABSTRACT Treponema denticola is an anaerobic spirochete strongly associated with human periodontal disease. T. denticola bacteria interact with a range of host tissue proteins, including fibronectin, laminin, and fibrinogen. The latter localizes in the extracellular matrix where tissue damage has occurred, and interactions with fibrinogen may play a key role in T. denticola colonization of the damaged sites. T. denticola ATCC 35405 showed saturable binding of fluid-phase fibrinogen to the cell surface and saturable adherence to immobilized fibrinogen. Levels of fibrinogen binding were enhanced

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Caimano, Melissa J., Kenneth W. Bourell, Teresa D. Bannister, David L. Cox, and Justin D. Radolf. "The Treponema denticola Major Sheath Protein Is Predominantly Periplasmic and Has Only Limited Surface Exposure." Infection and Immunity 67, no. 8 (1999): 4072–83. http://dx.doi.org/10.1128/iai.67.8.4072-4083.1999.

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ABSTRACT The recent discovery that the Treponema pallidum genome encodes 12 orthologs of the Treponema denticola major sheath protein (Msp) prompted us to reexamine the cellular location and topology of the T. denticola polypeptide. Experiments initially were conducted to ascertain whether Msp forms an array on or within the T. denticola outer membrane. Transmission electron microscopy (EM) of negatively stained and ultrathin-sectioned organisms failed to identify a typical surface layer, whereas freeze-fracture EM revealed that the T. denticola outer membrane contains heterogeneous transmembr

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Valeri, Clarissa, and Ciptadhi Tri Oka Binartha. "Efek antibakteri dan antibiofilm minyak atsiri cendana india (santalum album l.) Terdahap fusobacterium nucleatum dan treponema denticola (in vitro)." Jurnal Kedokteran Gigi Terpadu 6, no. 1 (2024): 93–96. http://dx.doi.org/10.25105/jkgt.v6i1.20915.

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Background: Periodontitis caused by pathogenic bacteria such as Fusobacterium nucleatum and Treponema denticola. Periodontitis prevented by chemical plaque control using chlorhexidine, but excessive chlorhexidine causes discoloration of the teeth. Indian sandalwood essential oil extract is a natural ingredient can be used as an alternative and have function inhibiting bacterial growth. Purpose: To determine the effect of Indian sandalwood essential oil in inhibiting the growth and biofilm of Fusobacterium nucleatum and Treponema denticola. Method: Fusobacterium nucleatum and Treponema denticol

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30

Umemoto, T., J. J. Zambon, R. J. Genco, and I. Namikawa. "Major Antigens of Human Oral Spirochetes Associated with Periodontal Disease." Advances in Dental Research 2, no. 2 (1988): 292–96. http://dx.doi.org/10.1177/08959374880020021401.

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Human oral spirochetes are prominent inhabitants of subgingival plaque in patients with periodontal disease. Measurements of serum antibody titers to these micro-organisms have been used to illuminate the role of human oral spirochetes in periodontal disease. In the present study, rabbit antisera to four oral spirochetes (including Treponema denticola ATCC33520 and three clinical isolates) were examined for reactivity to cell lysates. Western blotting demonstrated that the major treponemal antigens reactive with the rabbit antisera to T. denticola ATCC33520 and to strains 42, 48, and 57 posses

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31

Samudra, Kresna A. G., Abdul G. Soulissa, and Amelia S. Widyarman. "Antibiofilm Efficacy of Black Tiger Shrimp (Penaeus monodon) Chitosan against Aggregatibacter actinomycetemcomitans and Treponema denticola." e-GiGi 10, no. 2 (2022): 162. http://dx.doi.org/10.35790/eg.v10i2.39052.

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Abstract: Shrimp shell (carapace) contains chitosan which is reported to have antibacterial property against periodontal bacteria. This study aimed to determine the antibiofilm efficacy of chitosan obtained from black tiger shrimp (Penaeus monodon) against Aggregatibacter action-mycetemcomitans and Treponema denticola in vitro. The antibiofilm activity was tested using crystal violet biofilm assay with variations of chitosan concentrations, as follows: 0.2%, 0.4%, 0.6%, 0.8%, and 1%. Chlorhexidine 0.2% was used as the positive control and acetate 1% as the negative control with 3-hour-treatmen

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32

Lai, Yanlai, and Lianrui Chu. "Novel Mechanism for Conditional Aerobic Growth of the Anaerobic Bacterium Treponema denticola." Applied and Environmental Microbiology 74, no. 1 (2007): 73–79. http://dx.doi.org/10.1128/aem.01972-07.

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ABSTRACT Treponema denticola, a periodontal pathogen, has recently been shown to exhibit properties of a facultative anaerobic spirochete, in contrast to its previous recognition as an obligate anaerobic bacterium. In this study, the capacity and possible mechanism of T. denticola survival and growth under aerobic conditions were investigated. Factors detrimental to the growth of T. denticola ATCC 33405, such as oxygen concentration and hydrogen sulfide (H2S) levels as well as the enzyme activities of gamma-glutamyltransferase, cysteinylglycinase, and cystalysin associated with the cells were

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33

McDowell, John V., Bernice Huang, J. Christopher Fenno, and Richard T. Marconi. "Analysis of a Unique Interaction between the Complement Regulatory Protein Factor H and the Periodontal Pathogen Treponema denticola." Infection and Immunity 77, no. 4 (2009): 1417–25. http://dx.doi.org/10.1128/iai.01544-08.

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ABSTRACT Treponema denticola, a spirochete associated with periodontitis, is abundant at the leading edge of subgingival plaque, where it interacts with gingival epithelia. T. denticola produces a number of virulence factors, including dentilisin, a protease which is cytopathic to host cells, and FhbB, a unique T. denticola lipoprotein that binds complement regulatory proteins. Earlier analyses suggested that FhbB specifically bound to factor H (FH)-like protein 1 (FHL-1). However, by using dentilisin-deficient mutants of T. denticola, we found that T. denticola preferentially binds FH and not

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34

Cimasoni, G., and B. C. McBride. "Adherence of Treponema denticola to Modified Hydroxyapatite." Journal of Dental Research 66, no. 12 (1987): 1727–29. http://dx.doi.org/10.1177/00220345870660120601.

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Small samples of hydroxyapatite (HA) beads were coated with 10 μL of either saliva, serum, human crevicular fluid, or a preparation of lysosomal enzymes from human polymorphonuclear leucocytes (PMN), before being added to suspensions of Treponema denticola. The beads were then observed with the scanning electron microscope. Abundant T. denticola were found to adhere to HA or HA coated with saliva, serum, or crevicular fluid. Coating the beads with lysosomal enzymes consistently prevented the adhesion of T. denticola. Adhesion of treponemes to hard surfaces, modulated by enzymes from PMNs, coul

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35

Asai, Yasuyuki, Takayoshi Jinno, and Tomohiko Ogawa. "Oral Treponemes and Their Outer Membrane Extracts Activate Human Gingival Epithelial Cells through Toll-Like Receptor 2." Infection and Immunity 71, no. 2 (2003): 717–25. http://dx.doi.org/10.1128/iai.71.2.717-725.2003.

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ABSTRACT Oral treponemes are considered to be important in the development and progression of periodontal diseases. We investigated the mechanisms of recognition and activation of human gingival epithelial cells (HGEC) with the oral treponemes Treponema denticola, Treponema vincentii, and Treponema medium and their outer membrane extracts (OMEs). T. vincentii and T. medium but not T. denticola produced interleukin 8 (IL-8) in an HGEC culture. Further, all three treponemes induced IL-8 mRNA expression and NF-κB activation in HGEC. Among them, T. denticola especially exhibited trypsin- and chymo

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36

Bian, Jiang, J. Christopher Fenno, and Chunhao Li. "Development of a Modified Gentamicin Resistance Cassette for Genetic Manipulation of the Oral Spirochete Treponema denticola." Applied and Environmental Microbiology 78, no. 6 (2012): 2059–62. http://dx.doi.org/10.1128/aem.07461-11.

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ABSTRACTHerein, we report that a modified gentamicin cassette and a PCR-based method can be used for targeted mutagenesis of the oral spirocheteTreponema denticola. This approach minimizes polar effects and spontaneous antibiotic resistance. Therefore, it can serve as a reliable tool for genetic manipulation ofT. denticola.

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Miyamoto, Meguru, Kazuyuki Ishihara та Katsuji Okuda. "The Treponema denticola Surface Protease Dentilisin Degrades Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor Alpha". Infection and Immunity 74, № 4 (2006): 2462–67. http://dx.doi.org/10.1128/iai.74.4.2462-2467.2006.

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ABSTRACT Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.

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38

Slivienski-Gebhardt, Linda L., Jacques Izard, William A. Samsonoff, and Ronald J. Limberger. "Development of a Novel Chloramphenicol Resistance Expression Plasmid Used for Genetic Complementation of a fliG Deletion Mutant in Treponema denticola." Infection and Immunity 72, no. 9 (2004): 5493–97. http://dx.doi.org/10.1128/iai.72.9.5493-5497.2004.

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ABSTRACT A new expression plasmid containing the fla operon promoter and a staphylococcal chloramphenicol resistance gene, was constructed to help assess the role of fliG in Treponema denticola motility. Deletion of fliG resulted in a nonmotile mutant with a markedly decreased number of flagellar filaments. Wild-type fliG genes from T. denticola and from Treponema pallidum were cloned into this expression plasmid. In both cases, the gene restored the ability of the mutant to gyrate its cell ends and enabled colony spreading in agarose. This shuttle plasmid enables high-level expression of gene

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39

Rosen, Graciela, Michael N. Sela, and Gilad Bachrach. "The Antibacterial Activity of LL-37 against Treponema denticola Is Dentilisin Protease Independent and Facilitated by the Major Outer Sheath Protein Virulence Factor." Infection and Immunity 80, no. 3 (2011): 1107–14. http://dx.doi.org/10.1128/iai.05903-11.

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Host defense peptides are innate immune effectors that possess both bactericidal activities and immunomodulatory functions. Deficiency in the human host defense peptide LL-37 has previously been correlated with severe periodontal disease.Treponema denticolais an oral anaerobic spirochete closely associated with the pathogenesis of periodontal disease. TheT. denticolamajor surface protein (MSP), involved in adhesion and cytotoxicity, and the dentilisin serine protease are key virulence factors of this organism. In this study, we examined the interactions between LL-37 andT. denticola. The three

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40

Ozbek, Selcuk M., Ahmet Ozbek, and Aziz S. Erdogan. "Detection of Treponema Denticola in Symptomatic Apical Periodontitis and in Symptomatic Apical Abscesses by Real-Time PCR." European Journal of Dentistry 03, no. 02 (2009): 107–13. http://dx.doi.org/10.1055/s-0039-1697416.

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ABSTRACTObjectives: The aim of this study was to investigate the presence of Treponema denticola in symptomatic apical periodontitis and in symptomatic apical abscesses by real-time polymerase chain reaction (PCR) method.Methods: Microbial samples were collected from 60 single-rooted teeth having carious lesions and necrotic pulps. For each tooth, clinical data including patient symptoms were recorded. Teeth were categorized by diagnosis as having symptomatic apical periodontitis or symptomatic apical abscess. Aseptic microbial samples were collected using paper points from 30 infected root ca

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41

Chi, Bo, Sarita Chauhan, and Howard Kuramitsu. "Development of a System for Expressing Heterologous Genes in the Oral Spirochete Treponema denticola and Its Use in Expression of the Treponema pallidum flaA Gene." Infection and Immunity 67, no. 7 (1999): 3653–56. http://dx.doi.org/10.1128/iai.67.7.3653-3656.1999.

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ABSTRACT The present communication describes the construction of a newEscherichia coli-Treponema denticola shuttle vector based on the naturally occurring spirochete plasmid pTS1 and the expression of the heterologous T. pallidum flaA gene from the plasmid in T. denticola. This new shuttle vector system should prove useful in characterizing virulence factors from unculturable pathogenic spirochetes.

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42

Salsabila, Garina, Abdul G. Soulissa, and Armelia S. Widyarman. "Antibiofilm Effect of Rambutan Leaf Extract (Nephelium lappaceum L.) against Aggregatibacter actinomycetemcomitans and Treponema denticola (in vitro)." e-GiGi 10, no. 1 (2022): 103. http://dx.doi.org/10.35790/eg.v10i1.39050.

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Abstract: Commonly, periodontal disease is caused by bacteria in subgingival plaque, such as Aggregatibacter actinomycetemcomitans and Treponema denticola. Rambutan leaf (Nephelium lappaceum L.) contains phenolic compounds that can act as antibacterial; therefore, it can be an alternative for chemical treatment of this disease. This study aimed to determine the effect of rambutan leaf extract against A. actinomycetemcomitans and T. denticola biofilm adhesion. This was an experimental and laboratory study using the post-test only control group design. The biofilm adhesion resistance test was do

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43

Xu, Xiaoping, Stanley C. Holt, and David Kolodrubetz. "Cloning and Expression of Two Novel Hemin Binding Protein Genes from Treponema denticola." Infection and Immunity 69, no. 7 (2001): 4465–72. http://dx.doi.org/10.1128/iai.69.7.4465-4472.2001.

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ABSTRACT Treponema denticola does not appear to produce siderophores, so it must acquire iron by other pathways. Indeed,T. denticola has been shown to have an iron-regulated 44-kDa outer membrane protein (HbpA) with hemin binding ability. To characterize the HbpA protein, its gene was cloned from genomic DNA libraries of T. denticola. Sequence analysis of thehbpA open reading frame indicated that it encoded a 42.8-kDa protein with a 23-amino-acid signal peptide. HbpA has no significant homology to any proteins in the databases. Southern blot analysis demonstrated that hbpA is present in severa

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44

McDowell, John V., Justin Lankford, Lola Stamm, Tania Sadlon, David L. Gordon, and Richard T. Marconi. "Demonstration of Factor H-Like Protein 1 Binding to Treponema denticola, a Pathogen Associated with Periodontal Disease in Humans." Infection and Immunity 73, no. 11 (2005): 7126–32. http://dx.doi.org/10.1128/iai.73.11.7126-7132.2005.

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ABSTRACT Treponema denticola is an important contributor to periodontal disease. In this study we investigated the ability of T. denticola to bind the complement regulatory proteins factor H and factor H-like protein 1 (FHL-1). The binding of these proteins has been demonstrated to facilitate evasion of the alternative complement cascade and/or to play a role in adherence and invasion. Here we demonstrate that T. denticola specifically binds FHL-1 via a 14-kDa, surface-exposed protein that we designated FhbB. Consistent with its FHL-1 binding specificity, FhbB binds only to factor H recombinan

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45

Nishiyama, Sheila Alexandra Belini, Viviane Nakano, Gustavo Velásquez-Melendez, and Mario Julio Avila-Campos. "Occurrence of herpes simplex virus 1 and three periodontal bacteria in patients with chronic periodontitis and necrotic pulp." Canadian Journal of Microbiology 54, no. 4 (2008): 326–30. http://dx.doi.org/10.1139/w08-006.

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Viral and bacterial associations appear to be implicated in the development of periodontal infections. Little information is available describing the periodontopathic agents in root canals with necrotic pulp. In this study, the occurrence and the combinations among herpes simplex virus type 1 (HSV-1) and Dialister pneumosintes , Tannerella forsythia , and Treponema denticola in patients with chronic periodontitis and necrotic pulp were evaluated. Clinical samples from healthy subjects and patients with periodontal or pulp infections were analyzed using a nested polymerase chain reaction PCR to

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46

Fenno, J. Christopher, Muneaki Tamura, Pauline M. Hannam, Grace W. K. Wong, Roger A. Chan, and Barry C. McBride. "Identification of a Treponema denticola OppA Homologue That Binds Host Proteins Present in the Subgingival Environment." Infection and Immunity 68, no. 4 (2000): 1884–92. http://dx.doi.org/10.1128/iai.68.4.1884-1892.2000.

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ABSTRACT Proteins secreted or exported by Treponema denticolahave been implicated as mediators of specific interactions between the spirochete and subgingival tissues in periodontal diseases. However, limited information is available on the ability of this peptidolytic organism to bind or transport soluble peptides present in the subgingival environment. A prominent 70-kDa protein was isolated from surface extracts of T. denticola ATCC 35405. A clone expressing a portion of the protein was identified in anEscherichia coli expression library of T. denticola DNA. DNA sequence analysis showed tha

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47

Bian, Xue-lin, Hong-tao Wang, Yu Ning, Si Young Lee, and J. Christopher Fenno. "Mutagenesis of a Novel Gene in the prcA-prtP Protease Locus Affects Expression of Treponema denticola Membrane Complexes." Infection and Immunity 73, no. 2 (2005): 1252–55. http://dx.doi.org/10.1128/iai.73.2.1252-1255.2005.

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ABSTRACT A novel gene was identified in the Treponema denticola prcA-prtP protease operon. Strains with mutations in either the prcA-prtP or the msp region showed altered expression of a product(s) of the other locus. Together, these results provide information on the assembly of outer membrane complexes involved in T. denticola interaction with host cells and tissue.

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48

McDowell, John V., Jesse Frederick, Lola Stamm, and Richard T. Marconi. "Identification of the Gene Encoding the FhbB Protein of Treponema denticola, a Highly Unique Factor H-Like Protein 1 Binding Protein." Infection and Immunity 75, no. 2 (2006): 1050–54. http://dx.doi.org/10.1128/iai.01458-06.

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ABSTRACT The gene encoding the Treponema denticola factor H-like protein 1 (FHL-1) binding protein, FhbB, was recovered and characterized. Sequence conservation, expression, and properties of FhbB were analyzed. The identification of FhbB represents an important step in understanding the contribution of FHL-1 binding in T. denticola pathogenesis and in development of periodontal disease.

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49

Yang, Yu, Philip E. Stewart, Xiaoguang Shi, and Chunhao Li. "Development of a Transposon Mutagenesis System in the Oral Spirochete Treponema denticola." Applied and Environmental Microbiology 74, no. 20 (2008): 6461–64. http://dx.doi.org/10.1128/aem.01424-08.

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ABSTRACT Here, we report successful transposon mutagenesis in the oral spirochete Treponema denticola. A modified Himar1 transposon, including a new antibiotic selection cassette for T. denticola, generated mutations affecting cell division, transport, and chemotaxis, among other processes. This random mutagenesis system should facilitate research on the biology and pathogenesis of this spirochete, which is associated with human periodontal diseases.

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Ishihara, Kazuyuki, Howard K. Kuramitsu, Tadashi Miura, and Katsuji Okuda. "Dentilisin Activity Affects the Organization of the Outer Sheath of Treponema denticola." Journal of Bacteriology 180, no. 15 (1998): 3837–44. http://dx.doi.org/10.1128/jb.180.15.3837-3844.1998.

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ABSTRACT Prolyl-phenylalanine-specific serine protease (dentilisin) is a major extracellular protease produced by Treponema denticola. The gene, prtP, coding for the protease was recently cloned and sequenced (K. Ishihara, T. Miura, H. K. Kuramitsu, and K. Okuda, Infect. Immun. 64:5178–5186, 1996). In order to determine the role of this protease in the physiology and virulence of T. denticola, a dentilisin-deficient mutant, K1, was constructed following electroporation with aprtP-inactivated DNA fragment. No chymotrypsin-like protease activity was detected in the dentilisin-deficient mutant. I

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