Добірка наукової літератури з теми "DHCR24"

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Статті в журналах з теми "DHCR24"

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Lee, Bok-Soon, Ji-Hye Choi, Hyo Jeong Kim, et al. "Abstract 7585: Targeting of 7 or 24 dehydrocholesterol reductase decreases cancer progression in head and neck cancer." Cancer Research 84, no. 6_Supplement (2024): 7585. http://dx.doi.org/10.1158/1538-7445.am2024-7585.

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Abstract The elevated expression of cholesterol metabolism has been associated with many cancer including head and neck squamous cell carcinoma (HNSCC). However, the molecular mechanisms between cholesterol biosynthesis and head and neck cancer have not yet been studied. In this study, we identified upregulation of dehydrocholesterol reductase such as DHCR7 or DHCR24 in HNSCC compared with adjacent normal tissues from the same patients using RNA sequencing data. We observed protein expression level of DHCR7 or DHCR24 in head and neck cancer cell lines through Western blotting. We also checked
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2

Lu, Xiuli, Yang Li, Jianli Liu та ін. "The membrane topological analysis of 3β-hydroxysteroid-Δ24 reductase (DHCR24) on endoplasmic reticulum". Journal of Molecular Endocrinology 48, № 1 (2011): 1–9. http://dx.doi.org/10.1530/jme-11-0132.

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DHCR24encodes 3β-hydroxysteroid-Δ24 reductase, catalyzing the conversion of desmosterol to cholesterol. Our previous study demonstrated that DHCR24 exerts an anti-apoptotic function as a reactive oxygen species (ROS) scavenger, for which it needs its FAD-binding domain. The membrane topology of DHCR24 on endoplasmic reticulum (ER) and the functional significance of its FAD-binding domain are not completely understood. Based on the structure predicted by bioinformatics, we studied the membrane topology of DHCR24 in murine neuroblastoma cells (N2A), using the fluorescent protease protection (FPP
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3

Kuehnle, Katrin, Arames Crameri, Roland E. Kälin, et al. "Prosurvival Effect of DHCR24/Seladin-1 in Acute and Chronic Responses to Oxidative Stress." Molecular and Cellular Biology 28, no. 2 (2007): 539–50. http://dx.doi.org/10.1128/mcb.00584-07.

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ABSTRACT DHCR24/seladin-1, a crucial enzyme in sterol synthesis, is of lower abundance in brain areas affected by Alzheimer's disease. While high levels of DHCR24/seladin-1 exert antiapoptotic function by conferring resistance against oxidative stress, the molecular mechanism for this protective effect is not fully understood. Here we show that DHCR24/seladin-1 expression is up-regulated in an acute response and down-regulated in a chronic response to oxidative stress. High levels of DHCR24/seladin-1 were associated with elevated cholesterol concentrations and a general increase in cholesterol
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Li, Han, Zhen Yang, Wukaiyang Liang, Hao Nie, Jinhua Yan, and Cuntai Zhang. "DHCR24 INSUFFICIENCY PROMOTES VASCULAR ENDOTHELIAL CELL SENESCENCE AND ENDOTHELIAL DYSFUNCTION." Innovation in Aging 8, Supplement_1 (2024): 750. https://doi.org/10.1093/geroni/igae098.2440.

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Abstract Endothelial cells (ECs) senescence is critical for vascular dysfunction, which leads to age-related disease. DHCR24, a 3β-hydroxysterol δ 24 reductase with multiple functions other than enzymatic activity, has been involved in age-related disease. However, little is known about the relationship between DHCR24 and vascular ECs senescence. We revealed that DHCR24 expression is chronologically decreased in senescent human umbilical vein endothelial cells (HUVECs) and the aortas of aged mice. ECs senescence in endothelium-specific DHCR24 knockout mice was characterized by increased P16 an
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Lu, Xiuli, Fukushi Kambe, Xia Cao та ін. "3β-Hydroxysteroid-Δ24 Reductase Is a Hydrogen Peroxide Scavenger, Protecting Cells from Oxidative Stress-Induced Apoptosis". Endocrinology 149, № 7 (2008): 3267–73. http://dx.doi.org/10.1210/en.2008-0024.

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3β-Hydroxysteroid-Δ24 reductase (DHCR24) is an endoplasmic reticulum-resident, multifunctional enzyme that possesses antiapoptotic and cholesterol-synthesizing activities. To clarify the molecular basis of the former activity, we investigated the effects of hydrogen peroxide (H2O2) on embryonic fibroblasts prepared from DHCR24-knockout mice (DHCR24−/− mouse embryonic fibroblasts). H2O2 exposure rapidly induced apoptosis, which was associated with sustained activation of apoptosis signal-regulating kinase-1 and stress-activated protein kinases, such as p38 MAPK and c-Jun N-terminal kinase. Comp
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Zheng, Huifei Sophia, Yuan Kang, Qiongxia Lyu, et al. "DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex." International Journal of Molecular Sciences 24, no. 2 (2023): 933. http://dx.doi.org/10.3390/ijms24020933.

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Steroid hormones are synthesized through enzymatic reactions using cholesterol as the substrate. In steroidogenic cells, the required cholesterol for steroidogenesis can be obtained from blood circulation or synthesized de novo from acetate. One of the key enzymes that control cholesterol synthesis is 24-dehydrocholesterol reductase (encoded by DHCR24). In humans and rats, DHCR24 is highly expressed in the adrenal gland, especially in the zona fasciculata. We recently reported that DHCR24 was expressed in the mouse adrenal gland’s inner cortex and also found that thyroid hormone treatment sign
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Tallorin, Lorillee, Valerie A. Villareal, Chih-Yun Hsia, et al. "Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase." Journal of Biological Chemistry 295, no. 35 (2020): 12426–36. http://dx.doi.org/10.1074/jbc.ra120.013455.

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Many RNA viruses create specialized membranes for genome replication by manipulating host lipid metabolism and trafficking, but in most cases, we do not know the molecular mechanisms responsible or how specific lipids may impact the associated membrane and viral process. For example, hepatitis C virus (HCV) causes a specific, large-fold increase in the steady-state abundance of intracellular desmosterol, an immediate precursor of cholesterol, resulting in increased fluidity of the membrane where HCV RNA replication occurs. Here, we establish the mechanism responsible for HCV's effect on intrac
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Li, Yang, Xude Wang, Baoyu Yang та ін. "3β-Hydroxysteroid-Δ24 Reductase (DHCR24) Protects Pancreatic β Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species". Journal of Diabetes Research 2020 (17 липня 2020): 1–11. http://dx.doi.org/10.1155/2020/3426902.

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There is accumulating evidence showing that apoptosis induced by endoplasmic reticulum (ER) stress plays a key role in pancreatic β cell dysfunction and insulin resistance. 3β-Hydroxysteroid-Δ24 Reductase (DHCR24) is a multifunctional enzyme located in the endoplasmic reticulum (ER), which has been previously shown to protect neuronal cells from ER stress-induced apoptosis. However, the role of DHCR24 in type 2 diabetes is only incompletely understood so far. In the present study, we induced ER stress by tunicamycin (TM) treatment and showed that infection of MIN6 cells with Ad-DHCR24-myc rend
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Mack, Yin Shan Isa, Masatoshi Dehari, Nobukatsu Morooka, and Shinji Nagata. "Identification and Characterization of 24-Dehydrocholesterol Reductase (DHCR24) in the Two-Spotted Cricket, Gryllus bimaculatus." Insects 12, no. 9 (2021): 782. http://dx.doi.org/10.3390/insects12090782.

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Анотація:
Arthropods, including insects, convert sterols into cholesterol due to the inability to synthesise cholesterol de novo. 24-dehydrocholesterol reductase (DHCR24) plays an important role in the conversion. Not only involving the cholesterol biosynthesis in vertebrates, DHCR24 is required for the conversion of desmosterol into cholesterol in phytophagous insects. The current study extensively examined DHCR24 in omnivorous insects, which feed on both plants and animals, using Gryllus bimaculatus as the experimental model. We identified cDNAs encoding two homologues of DHCR24 from G. bimaculatus, w
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Zhang, Rui, Siyuan Peng, Xuejuan Zhang, Zhengwei Huang, and Xin Pan. "High mRNA Expression of 24 Dehydrocholesterol Reductase (DHCR24) in the Treatment of Doxorubicin-Induced Heart Failure in Rats." International Journal of Molecular Sciences 26, no. 1 (2025): 312. https://doi.org/10.3390/ijms26010312.

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Objective: The objective of this study was to explore the possibility of treating heart failure in rats by delivering mRNA of 24-dehydrocholesterol reductase (DHCR24) into the body through lipid nanoparticles (LNPs). Methods: We established a heart failure rat model using doxorubicin. The experiment was divided into blank, model, mRNA stock solution cardiac injection, mRNA stock solution intravenous injection, LNP-mRNA stock solution cardiac injection, and LNP-mRNA stock solution intravenous injection groups. We directly injected DHCR24-mRNA or LNP-DHCR24-mRNA into the myocardium in three regi
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Дисертації з теми "DHCR24"

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Zadworny, David, Devanand Sarkar, Tsuneo Imai, Rusella Mirza, Fukushi Kambe та Hisao Seo. "The Involvement of 3β-hydroxysterol-Δ^24-reductase, A Post-squalene Enzyme in Cholesterol Biosynthesis, in Desmosterolosis". Research Institute of Environmental Medicine, Nagoya University, 2003. http://hdl.handle.net/2237/7557.

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Yashar, Sadian [Verfasser], Roger S. [Akademischer Betreuer] Goody, and Roland [Akademischer Betreuer] Winter. "Regulation of septin filament formation and cholesterol production by DHCR7 / Sadian Yashar. Betreuer: Roger S. Goody. Gutachter: Roland Winter." Dortmund : Universitätsbibliothek Dortmund, 2013. http://d-nb.info/1099913608/34.

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Bancin, Lamtiur Junita, and Lamtiur Junita Bancin. "Beaches as Sentinels for Ocean Plastic Pollution: Microplastic and Mesoplastic Pollution on Xia-Liao Beach, New Taipei City, Taiwan." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/dhcg2h.

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KAO, TZU-HSIANG, and 高子翔. "The Design and Implementation of Fuzz testing for OPC-UA, NetBIOS and DHCPv4." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/525q68.

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碩士<br>銘傳大學<br>資訊工程學系碩士班<br>106<br>This thesis uses fuzz testing techniques to identify potential threats for the three protocols: OPC-UA, NetBIOS, and DHCPv4 in order to improve the security of these network protocols. The process of fuzzy testing is divided into four steps: (1) To study the packet format and transmission method of the network protocol. (2) To input the test formant and data into the developed program on the user side. (3) To install the server and fuzz the server with the developed program. (4) To use Wireshark to check if there are any abnormal packets. Client uses Linux as
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Книги з теми "DHCR24"

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Daniel, Conviser, Grannis Alexander B. 1942-, Murtaugh Brian 1937-, and New York (State). Legislature. Assembly. Committee on Oversight, Analysis & Investigation, eds. Bleak House: DHCR at the crossroads : findings and recommendations of the joint Assembly committees' investigation of rent administration in New York State. NYS Assembly, Committee on Housing and Committee on Oversight, Analysis and Investigation, 1987.

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Shapiro's DHCR Decision Finder. Vendome Group, LLC, 2007.

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Lee, Ryan W. Smith-Lemli-Opitz Syndrome. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0078.

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Smith-Lemli-Opitz syndrome (OMIM 270400) (SLOS) is a multiple congenital anomaly disorder caused by an inborn error of cholesterol synthesis. Studies demonstrated that mutations in the gene for 3b-hydroxysterol-D7 reductase (DHCR7) result in low plasma cholesterol and corresponding increases in 7DHC. Distinctive facial features of include ptosis, small nose with anteverted nares, and micrognathia. Acral dysgenesis is common, foremost of which involve syndactyly and polydactyly. Children with SLOS often have a behavioral phenotype within the autism spectrum.
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Частини книг з теми "DHCR24"

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Brown, Laura S. "Exploring intersectional identities in DHCR trauma healing." In Decolonizing trauma healing: Toward a humble, culturally responsive practice. American Psychological Association, 2025. http://dx.doi.org/10.1037/0000421-007.

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Shan, Duo, An-jun Xu, Yong-ming Lu, and Hong-bing Wang. "Research on Modeling and Optimization Algorithm for Hot Rolling Batch Planning of DHCR Production." In International Asia Conference on Industrial Engineering and Management Innovation (IEMI2012) Proceedings. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-38445-5_54.

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Brown, Laura S. "Aren’t there already some DHCR trauma healing methodologies? And what can we learn from them?" In Decolonizing trauma healing: Toward a humble, culturally responsive practice. American Psychological Association, 2025. http://dx.doi.org/10.1037/0000421-014.

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Schwarzkopf, Maayan, Harry M. T. Choi, and Niles A. Pierce. "Multiplexed Quantitative In Situ Hybridization for Mammalian Cells on a Slide: qHCR and dHCR Imaging (v3.0)." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0623-0_9.

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Choi, Harry M. T., Maayan Schwarzkopf, and Niles A. Pierce. "Multiplexed Quantitative In Situ Hybridization with Subcellular or Single-Molecule Resolution Within Whole-Mount Vertebrate Embryos: qHCR and dHCR Imaging (v3.0)." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0623-0_10.

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Тези доповідей конференцій з теми "DHCR24"

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Wu, Dewang, Mei Tian, Haoyu Tian, et al. "Upregulation of DHCR24 in cervical cancer promotes cervical cancer development and correlates with immune infiltration and tumor stemness." In ICBET 2024: 2024 14th International Conference on Biomedical Engineering and Technology. ACM, 2024. http://dx.doi.org/10.1145/3678935.3678939.

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Honorato, Pedro Fechine, Renata Braga Vale, Larissa Luana Lopes Lima, et al. "Principais características clínicas da síndrome de Smith-Lemli-Opitz." In V SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvmulti2024-176.

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A síndrome de Smith-Lemli-Opitz (SLOS) resulta de mutações no gene DHCR7 (11q13), causando deficiência de colesterol e acúmulo de 7-dehidrocolesterol nos tecidos. Isso causa uma variedade de sintomas, como deficiência intelectual e malformações craniofaciais.
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Rao, R., H. J. J. Kim, S. Jiang та ін. "DHCR7 Deficiency Promotes 7β-hydroxycholesterol Accumulation and Endothelial Apoptosis in Pulmonary Hypertension". У American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7133.

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Shek, Gordon K., and Harry Seahra. "Effect of Hydrogen Isotope and Concentration on Delayed Hydride Crack Growth Rates in Zr-2.5Nb Pressure Tubes." In 18th International Conference on Nuclear Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/icone18-29786.

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CANDU Zr-2.5 Nb pressure tubes are susceptible to a cracking mechanism known as Delayed Hydride Cracking (DHC), which is a repetitive process that involves hydrogen diffusion, hydride precipitation and fracture at a crack tip. As defense-in-depth, when DHC is postulated to have initiated from a flaw, it is required to demonstrate that the crack can be detected by the leak monitoring system and the reactor safely shut down before the crack reaches the critical length for pressure tube rupture. DHC growth rates (DHCR) in the axial direction of the tube are required for such leak-before-break ass
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Shah, Kunal Ravindra, and Dipak Dattatray Badgujar. "Devnagari handwritten character recognition (DHCR) for ancient documents: A review." In 2013 IEEE Conference on Information & Communication Technologies (ICT). IEEE, 2013. http://dx.doi.org/10.1109/cict.2013.6558176.

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Li, Sujian, Helan Liang, Yanjun Huang, and Bo Hu. "Slab Cluster Based Planning and Scheduling Method of CC-DHCR." In 2009 International Conference on Advanced Computer Control. IEEE, 2009. http://dx.doi.org/10.1109/icacc.2009.79.

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Ai, Wei, Kenli Li, Cen Chen, Jiwu Peng, and Keqin Li. "DHCRF: A Distributed Conditional Random Field Algorithm on a Heterogeneous CPU-GPU Cluster for Big Data." In 2017 IEEE 37th International Conference on Distributed Computing Systems (ICDCS). IEEE, 2017. http://dx.doi.org/10.1109/icdcs.2017.66.

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Lv, Zhimin, Gang Xu, Xuejun Zhang, and Jian Xu. "Application of an Intelligent Integrated Planning and Scheduling System for DHCR." In 2009 International Workshop on Intelligent Systems and Applications. IEEE, 2009. http://dx.doi.org/10.1109/iwisa.2009.5072741.

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Wang, B., F. Wang, and X. Zhu. "Influence of Different Cooling Microstructure on Surface Cracks of HSLA Steel Plate by DHCR." In MS&T17. MS&T17, 2017. http://dx.doi.org/10.7449/2017/mst_2017_916_923.

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Wang, B., F. Wang, and X. Zhu. "Influence of Different Cooling Microstructure on Surface Cracks of HSLA Steel Plate by DHCR." In MS&T17. MS&T17, 2017. http://dx.doi.org/10.7449/2017mst/2017/mst_2017_916_923.

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Звіти організацій з теми "DHCR24"

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Kinnear, K., M. Stapp, R. Desetti, et al. DHCPv4 Bulk Leasequery. RFC Editor, 2013. http://dx.doi.org/10.17487/rfc6926.

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Kinnear, K., M. Stapp, B. Volz, and N. Russell. Active DHCPv4 Lease Query. RFC Editor, 2015. http://dx.doi.org/10.17487/rfc7724.

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Johnson, R. TFTP Server Address Option for DHCPv4. RFC Editor, 2010. http://dx.doi.org/10.17487/rfc5859.

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Sun, Q., Y. Cui, M. Siodelski, S. Krishnan, and I. Farrer. DHCPv4-over-DHCPv6 (DHCP 4o6) Transport. RFC Editor, 2014. http://dx.doi.org/10.17487/rfc7341.

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Farrer, I., Q. Sun, Y. Cui, and L. Sun. Softwire Provisioning Using DHCPv4 over DHCPv6. RFC Editor, 2019. http://dx.doi.org/10.17487/rfc8539.

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Colitti, L., J. Linkova, M. Richardson, and T. Mrugalski. IPv6-Only Preferred Option for DHCPv4. RFC Editor, 2020. http://dx.doi.org/10.17487/rfc8925.

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Joshi, B., R. Desetti, and M. Stapp. The DHCPv4 Relay Agent Identifier Sub-Option. RFC Editor, 2013. http://dx.doi.org/10.17487/rfc6925.

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Kurapati, P., R. Desetti, and B. Joshi. DHCPv4 Lease Query by Relay Agent Remote ID. RFC Editor, 2011. http://dx.doi.org/10.17487/rfc6148.

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Kinnear, K., R. Johnson, and M. Stapp. Virtual Subnet Selection Options for DHCPv4 and DHCPv6. RFC Editor, 2012. http://dx.doi.org/10.17487/rfc6607.

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Volz, B. Reclassifying Dynamic Host Configuration Protocol version 4 (DHCPv4) Options. RFC Editor, 2004. http://dx.doi.org/10.17487/rfc3942.

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