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Статті в журналах з теми "DHCR24"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Lee, Bok-Soon, Ji-Hye Choi, Hyo Jeong Kim, et al. "Abstract 7585: Targeting of 7 or 24 dehydrocholesterol reductase decreases cancer progression in head and neck cancer." Cancer Research 84, no. 6_Supplement (2024): 7585. http://dx.doi.org/10.1158/1538-7445.am2024-7585.

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Abstract The elevated expression of cholesterol metabolism has been associated with many cancer including head and neck squamous cell carcinoma (HNSCC). However, the molecular mechanisms between cholesterol biosynthesis and head and neck cancer have not yet been studied. In this study, we identified upregulation of dehydrocholesterol reductase such as DHCR7 or DHCR24 in HNSCC compared with adjacent normal tissues from the same patients using RNA sequencing data. We observed protein expression level of DHCR7 or DHCR24 in head and neck cancer cell lines through Western blotting. We also checked

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2

Lu, Xiuli, Yang Li, Jianli Liu та ін. "The membrane topological analysis of 3β-hydroxysteroid-Δ24 reductase (DHCR24) on endoplasmic reticulum". Journal of Molecular Endocrinology 48, № 1 (2011): 1–9. http://dx.doi.org/10.1530/jme-11-0132.

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DHCR24encodes 3β-hydroxysteroid-Δ24 reductase, catalyzing the conversion of desmosterol to cholesterol. Our previous study demonstrated that DHCR24 exerts an anti-apoptotic function as a reactive oxygen species (ROS) scavenger, for which it needs its FAD-binding domain. The membrane topology of DHCR24 on endoplasmic reticulum (ER) and the functional significance of its FAD-binding domain are not completely understood. Based on the structure predicted by bioinformatics, we studied the membrane topology of DHCR24 in murine neuroblastoma cells (N2A), using the fluorescent protease protection (FPP

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3

Kuehnle, Katrin, Arames Crameri, Roland E. Kälin, et al. "Prosurvival Effect of DHCR24/Seladin-1 in Acute and Chronic Responses to Oxidative Stress." Molecular and Cellular Biology 28, no. 2 (2007): 539–50. http://dx.doi.org/10.1128/mcb.00584-07.

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ABSTRACT DHCR24/seladin-1, a crucial enzyme in sterol synthesis, is of lower abundance in brain areas affected by Alzheimer's disease. While high levels of DHCR24/seladin-1 exert antiapoptotic function by conferring resistance against oxidative stress, the molecular mechanism for this protective effect is not fully understood. Here we show that DHCR24/seladin-1 expression is up-regulated in an acute response and down-regulated in a chronic response to oxidative stress. High levels of DHCR24/seladin-1 were associated with elevated cholesterol concentrations and a general increase in cholesterol

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4

Li, Han, Zhen Yang, Wukaiyang Liang, Hao Nie, Jinhua Yan, and Cuntai Zhang. "DHCR24 INSUFFICIENCY PROMOTES VASCULAR ENDOTHELIAL CELL SENESCENCE AND ENDOTHELIAL DYSFUNCTION." Innovation in Aging 8, Supplement_1 (2024): 750. https://doi.org/10.1093/geroni/igae098.2440.

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Abstract Endothelial cells (ECs) senescence is critical for vascular dysfunction, which leads to age-related disease. DHCR24, a 3β-hydroxysterol δ 24 reductase with multiple functions other than enzymatic activity, has been involved in age-related disease. However, little is known about the relationship between DHCR24 and vascular ECs senescence. We revealed that DHCR24 expression is chronologically decreased in senescent human umbilical vein endothelial cells (HUVECs) and the aortas of aged mice. ECs senescence in endothelium-specific DHCR24 knockout mice was characterized by increased P16 an

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5

Lu, Xiuli, Fukushi Kambe, Xia Cao та ін. "3β-Hydroxysteroid-Δ24 Reductase Is a Hydrogen Peroxide Scavenger, Protecting Cells from Oxidative Stress-Induced Apoptosis". Endocrinology 149, № 7 (2008): 3267–73. http://dx.doi.org/10.1210/en.2008-0024.

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3β-Hydroxysteroid-Δ24 reductase (DHCR24) is an endoplasmic reticulum-resident, multifunctional enzyme that possesses antiapoptotic and cholesterol-synthesizing activities. To clarify the molecular basis of the former activity, we investigated the effects of hydrogen peroxide (H2O2) on embryonic fibroblasts prepared from DHCR24-knockout mice (DHCR24−/− mouse embryonic fibroblasts). H2O2 exposure rapidly induced apoptosis, which was associated with sustained activation of apoptosis signal-regulating kinase-1 and stress-activated protein kinases, such as p38 MAPK and c-Jun N-terminal kinase. Comp

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6

Zheng, Huifei Sophia, Yuan Kang, Qiongxia Lyu, et al. "DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex." International Journal of Molecular Sciences 24, no. 2 (2023): 933. http://dx.doi.org/10.3390/ijms24020933.

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Steroid hormones are synthesized through enzymatic reactions using cholesterol as the substrate. In steroidogenic cells, the required cholesterol for steroidogenesis can be obtained from blood circulation or synthesized de novo from acetate. One of the key enzymes that control cholesterol synthesis is 24-dehydrocholesterol reductase (encoded by DHCR24). In humans and rats, DHCR24 is highly expressed in the adrenal gland, especially in the zona fasciculata. We recently reported that DHCR24 was expressed in the mouse adrenal gland’s inner cortex and also found that thyroid hormone treatment sign

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7

Tallorin, Lorillee, Valerie A. Villareal, Chih-Yun Hsia, et al. "Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase." Journal of Biological Chemistry 295, no. 35 (2020): 12426–36. http://dx.doi.org/10.1074/jbc.ra120.013455.

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Many RNA viruses create specialized membranes for genome replication by manipulating host lipid metabolism and trafficking, but in most cases, we do not know the molecular mechanisms responsible or how specific lipids may impact the associated membrane and viral process. For example, hepatitis C virus (HCV) causes a specific, large-fold increase in the steady-state abundance of intracellular desmosterol, an immediate precursor of cholesterol, resulting in increased fluidity of the membrane where HCV RNA replication occurs. Here, we establish the mechanism responsible for HCV's effect on intrac

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8

Li, Yang, Xude Wang, Baoyu Yang та ін. "3β-Hydroxysteroid-Δ24 Reductase (DHCR24) Protects Pancreatic β Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species". Journal of Diabetes Research 2020 (17 липня 2020): 1–11. http://dx.doi.org/10.1155/2020/3426902.

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There is accumulating evidence showing that apoptosis induced by endoplasmic reticulum (ER) stress plays a key role in pancreatic β cell dysfunction and insulin resistance. 3β-Hydroxysteroid-Δ24 Reductase (DHCR24) is a multifunctional enzyme located in the endoplasmic reticulum (ER), which has been previously shown to protect neuronal cells from ER stress-induced apoptosis. However, the role of DHCR24 in type 2 diabetes is only incompletely understood so far. In the present study, we induced ER stress by tunicamycin (TM) treatment and showed that infection of MIN6 cells with Ad-DHCR24-myc rend

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9

Mack, Yin Shan Isa, Masatoshi Dehari, Nobukatsu Morooka, and Shinji Nagata. "Identification and Characterization of 24-Dehydrocholesterol Reductase (DHCR24) in the Two-Spotted Cricket, Gryllus bimaculatus." Insects 12, no. 9 (2021): 782. http://dx.doi.org/10.3390/insects12090782.

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Arthropods, including insects, convert sterols into cholesterol due to the inability to synthesise cholesterol de novo. 24-dehydrocholesterol reductase (DHCR24) plays an important role in the conversion. Not only involving the cholesterol biosynthesis in vertebrates, DHCR24 is required for the conversion of desmosterol into cholesterol in phytophagous insects. The current study extensively examined DHCR24 in omnivorous insects, which feed on both plants and animals, using Gryllus bimaculatus as the experimental model. We identified cDNAs encoding two homologues of DHCR24 from G. bimaculatus, w

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10

Zhang, Rui, Siyuan Peng, Xuejuan Zhang, Zhengwei Huang, and Xin Pan. "High mRNA Expression of 24 Dehydrocholesterol Reductase (DHCR24) in the Treatment of Doxorubicin-Induced Heart Failure in Rats." International Journal of Molecular Sciences 26, no. 1 (2025): 312. https://doi.org/10.3390/ijms26010312.

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Objective: The objective of this study was to explore the possibility of treating heart failure in rats by delivering mRNA of 24-dehydrocholesterol reductase (DHCR24) into the body through lipid nanoparticles (LNPs). Methods: We established a heart failure rat model using doxorubicin. The experiment was divided into blank, model, mRNA stock solution cardiac injection, mRNA stock solution intravenous injection, LNP-mRNA stock solution cardiac injection, and LNP-mRNA stock solution intravenous injection groups. We directly injected DHCR24-mRNA or LNP-DHCR24-mRNA into the myocardium in three regi

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11

Martiskainen, Henna, Kaisa M. A. Paldanius, Teemu Natunen, et al. "DHCR24 exerts neuroprotection upon inflammation-induced neuronal death." Journal of Neuroinflammation 14, no. 1 (2017): 215. https://doi.org/10.1186/s12974-017-0991-6.

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<strong>Background: </strong>DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease.<strong>Methods: </strong>Here, we investigated whether the overexpression of DHCR24 protects neurons against inflammation-induced neuronal death using co-cultures of mouse embryonic primary cortical neurons and BV2 microglial cells upon acute neuroinflammation. Moreover, the effects of DHCR24 overexpression on dendritic spine densit

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12

Zhang, Xiaodong, Qiangqiang Tao, Jinnan Shang та ін. "MiR-26a promotes apoptosis of porcine granulosa cells by targeting the 3β-hydroxysteroid-Δ24-reductase gene". Asian-Australasian Journal of Animal Sciences 33, № 4 (2020): 547–55. http://dx.doi.org/10.5713/ajas.19.0173.

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Objective: Apoptosis of ovarian granulosa cells (GCs) affects mammalian follicular development and fecundity. This study aimed to explore the regulatory relationship between microRNA-26a (miR-26a) and the 3β-hydroxysteroid-Δ24-reductase gene (<i>DHCR24</i>) gene in porcine follicular granular cells (pGCs), and to provide empirical data for the development of methods to improve the reproductive capacity of pigs.Methods: The pGCs were transfected with miR-26a mimic, miR-26a inhibitor and <i>DHCR24</i>-siRNA <i>in vitro</i>. The cell apoptosis rate of pGCs was

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13

Shen, Yajie, Jingqi Zhou, Kui Nie, et al. "Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2+ diffuse large B-cell lymphomas." Blood 139, no. 1 (2022): 73–86. http://dx.doi.org/10.1182/blood.2021012327.

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Abstract Although oncogenicity of the stem cell regulator SOX9 has been implicated in many solid tumors, its role in lymphomagenesis remains largely unknown. In this study, SOX9 was overexpressed preferentially in a subset of diffuse large B-cell lymphomas (DLBCLs) that harbor IGH-BCL2 translocations. SOX9 positivity in DLBCL correlated with an advanced stage of disease. Silencing of SOX9 decreased cell proliferation, induced G1/S arrest, and increased apoptosis of DLBCL cells, both in vitro and in vivo. Whole-transcriptome analysis and chromatin immunoprecipitation–sequencing assays identifie

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14

Huang, Chen-Che Jeff, Yuan Kang, and Huifei Zheng. "OR19-1 Ncor1 Regulates the Expression of Dhcr24, which Controls de novo Cholesterol Synthesis in the Adrenal Gland Inner Cortex." Journal of the Endocrine Society 6, Supplement_1 (2022): A800. http://dx.doi.org/10.1210/jendso/bvac150.1656.

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Abstract In many types of cells and tissues, the nuclear receptor corepressor 1 (Ncor1) is known as a main corepressor that interacts with thyroid hormone receptors (i.e., TRα, TRβ1, and TRβ2). In the absence of thyroid hormone (T3), NCOR1 is recruited by TRs to inhibit gene transcription. In the liver, the deletion of Ncor1 increases hepatic triglyceride levels. However, the detailed mechanism of how NCOR1 is involved in thyroid hormone signaling in different types of tissues is not fully understood. Our previous study showed that TRβ1 is expressed in the adrenal gland inner cortex and T3 tre

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15

Falero-Diaz, Gustavo, Catarina de A. Barboza, Katherine Kaiser, et al. "The Systemic Effect of Ischemia Training and Its Impact on Bone Marrow-Derived Monocytes." Cells 13, no. 19 (2024): 1602. http://dx.doi.org/10.3390/cells13191602.

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Objective: Monocytes are innate immune cells that play a central role in inflammation, an essential component during neovascularization. Our recent publication demonstrated that ischemia training by 24 h unilateral occlusion of the femoral artery (FA) can modify bone marrow-derived monocytes (BM-Mono), allowing them to improve collateral remodeling in a mouse model of hindlimb ischemia. Here, we expand on our previous findings, investigating a potential systemic effect of ischemia training and how this training can impact BM-Mono. Methods and Results: BM-Mono from mice exposed to ischemia trai

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16

Wang, Haozhen, Ziyin Lu, Yang Li, et al. "Virtual Screening of Novel 24-Dehydroxysterol Reductase (DHCR24) Inhibitors and the Biological Evaluation of Irbesartan in Cholesterol-Lowering Effect." Molecules 28, no. 6 (2023): 2643. http://dx.doi.org/10.3390/molecules28062643.

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Hyperlipidemia is a risk factor for the development of fatty liver and cardiovascular diseases such as atherosclerosis and coronary heart disease, and hence, cholesterol-lowering drugs are considered important and effective in preventing cardiovascular diseases. Thus, researchers in the field of new drug development are endeavoring to identify new types of cholesterol-lowering drugs. 3β-hydroxysterol-Δ(24)-reductase (DHCR24) catalyzes the conversion of desmosterol to cholesterol, which is the last step in the cholesterol biosynthesis pathway. We speculated that blocking the catalytic activity

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17

Jin, Kai, Yiling Wang, Changhua Sun, et al. "DHCR24 (24-Dehydrocholesterol Reductase) Associated in Modulating Steroid Biosynthesis Pathway Regulates the Differentiation of Chicken Embryonic Stem Cells into Male Germ Cells." Journal of Biomaterials and Tissue Engineering 12, no. 8 (2022): 1550–57. http://dx.doi.org/10.1166/jbt.2022.3083.

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Spermatogonia stem cells (SSCs) have become one of the hotspots in modern life science research in the 21st century because of the broad application prospects in medicine, biology and animal breeding. Studies have shown that steroid biosynthesis signaling pathway is involved in the multiple cell differentiation process, but the formation of SSCs is not clear. DHCR24 proved in our outcome that it play an important part in steroid biosynthesis. Without the absent of DHCR24, CYP7A1 and PTCH2 are not keeping the expression of downstream genes. It’s the downregulation of the steroid biosynthesis pa

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18

Schroor, Maite M., Fatma B. A. Mokhtar, Jogchum Plat, and Ronald P. Mensink. "Associations between SNPs in Intestinal Cholesterol Absorption and Endogenous Cholesterol Synthesis Genes with Cholesterol Metabolism." Biomedicines 9, no. 10 (2021): 1475. http://dx.doi.org/10.3390/biomedicines9101475.

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Single nucleotide polymorphisms (SNPs) have been associated with cholesterol metabolism and may partly explain large inter-individual variability in intestinal cholesterol absorption and endogenous cholesterol synthesis rates. This cross-sectional study therefore examined whether SNPs in genes encoding for proteins involved in intestinal cholesterol absorption (ABCG5, ABCG8, and NPC1L1) and endogenous cholesterol synthesis (CYP51A1, DHCR7, DHCR24, HMGCR, HSD17B7, LBR, and MSMO1) were associated with intestinal cholesterol absorption markers (total cholesterol (TC) standardized campesterol and

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19

Luu, Winnie, Gene Hart-Smith, Laura J. Sharpe, and Andrew J. Brown. "The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally." Journal of Lipid Research 56, no. 4 (2015): 888–97. http://dx.doi.org/10.1194/jlr.m056986.

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20

Gauronskas, Phillip Joseph, Tayab Waseem, Jeffrey McDonald, Carlos Fernandez-Hernando, and Elena Galkina. "Desmosterol, an intermediate of cholesterol biosynthesis, modulates B cell activation and functions." Journal of Immunology 204, no. 1_Supplement (2020): 151.5. http://dx.doi.org/10.4049/jimmunol.204.supp.151.5.

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Abstract Introduction Atherosclerosis is a disease of large/medium size vessels attributed to a hyperlipidemic environment and a low-grade chronic inflammation. Normally, macrophages uptake modified low-density lipoprotein (mLDL), resulting in excess intracellular desmosterol, an immediate precursor to cholesterol, which promotes anti-inflammatory signaling. In contrast, mLDL uptake by macrophages in atherosclerosis produces foam cells that play an atherogenic role. While it has been previously shown that B cells can uptake mLDL, it remains unclear how mLDL uptake modulates B cell phenotype. M

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21

Ma, Shelby, Alina Moriarty, W. Coles Keeter, Natalie Ann Stahr, Cassandra Lee Kirk, and Tayab Waseem. "Desmosterol plays an atheroprotective role in B cells through B cell subset differentiation and B cell activation." Journal of Immunology 210, no. 1_Supplement (2023): 148.21. http://dx.doi.org/10.4049/jimmunol.210.supp.148.21.

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Abstract Atherosclerosis is a complex, inflammatory disease associated with lipid accumulation, vascular dysfunction, and inflammatory immune response in the large and medium sized arteries. B cell roles in atherosclerosis are subset specific. Increasing evidence suggests a role for glucose metabolism in shaping the immune response, but less is known about cholesterol metabolism and adaptive immunity. Desmosterol, a precursor of cholesterol in the Bloch cholesterol biosynthesis pathway, serves as a negative regulator of macrophages. To date, the effect of intermediates of cholesterol metabolis

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22

Schrader, Silja, Alexander Perfilyev, Mats Martinell, Sonia García-Calzón, and Charlotte Ling. "Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes." Epigenomics 13, no. 12 (2021): 919–25. http://dx.doi.org/10.2217/epi-2020-0442.

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Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previo

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23

Rebbani, Khadija, and Kyoko Tsukiyama-Kohara. "HCV-Induced Oxidative Stress: Battlefield-Winning Strategy." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/7425628.

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About 150 million people worldwide are chronically infected with hepatitis C virus (HCV). The persistence of the infection is controlled by several mechanisms including the induction of oxidative stress. HCV relies on this strategy to redirect lipid metabolism machinery and escape immune response. The 3β-hydroxysterol Δ24-reductase (DHCR24) is one of the newly discovered host markers of oxidative stress. This protein, as HCV-induced oxidative stress responsive protein, may play a critical role in the pathogenesis of HCV chronic infection and associated liver diseases, when aberrantly expressed

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24

Yoshinari, Kouichi, Hitoshi Ohno, Satoshi Benoki, and Yasushi Yamazoe. "Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase." Toxicology Letters 208, no. 2 (2012): 185–91. http://dx.doi.org/10.1016/j.toxlet.2011.11.003.

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25

Giannini, S., S. Benvenuti, P. Luciani, et al. "Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system: the involvement of the neuroprotective factor DHCR24 (Seladin-1)." Journal of Endocrinology 198, no. 3 (2008): 523–32. http://dx.doi.org/10.1677/joe-07-0613.

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The exposure of neurons to high glucose concentrations is considered a determinant of diabetic neuropathy, whereas members of the IGF system are neurotropic factors. Here, we investigated the effects of constant and intermittent high glucose concentrations on IGF1 and IGF-binding proteins (IGFBPs) in human neuroblast long-term cell cultures fetal neuroepithelial cells (FNC). These cells express the IGF1 receptor, and express and release in the culture medium IGFBP2, IGFBP4, and IGF1. The release of IGF1 was significantly increased by 17β-estradiol (10 nM). IGF1 (100 nM) treatment determined a

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26

Körner, Andreas, Enchen Zhou, Christoph Müller та ін. "Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution". Proceedings of the National Academy of Sciences 116, № 41 (2019): 20623–34. http://dx.doi.org/10.1073/pnas.1911992116.

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Targeting metabolism through bioactive key metabolites is an upcoming future therapeutic strategy. We questioned how modifying intracellular lipid metabolism could be a possible means for alleviating inflammation. Using a recently developed chemical probe (SH42), we inhibited distal cholesterol biosynthesis through selective inhibition of Δ24-dehydrocholesterol reductase (DHCR24). Inhibition of DHCR24 led to an antiinflammatory/proresolving phenotype in a murine peritonitis model. Subsequently, we investigated several omics layers in order to link our phenotypic observations with key metabolic

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27

Heerdegen, Desirée, Doreen Reuter, Moritz M. Kornmayer, et al. "Synthesis of Seco ‐Analogues of the DHCR24 Inhibitor SH‐42." European Journal of Organic Chemistry 2020, no. 39 (2020): 6270–88. http://dx.doi.org/10.1002/ejoc.202001080.

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28

Liu, Xiao-Ping, Xiao-Hong Yin, Xiang-Yu Meng, et al. "DHCR24 predicts poor clinicopathological features of patients with bladder cancer." Medicine 97, no. 39 (2018): e11830. http://dx.doi.org/10.1097/md.0000000000011830.

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29

Dei Cas, Michele, Chiara Maura Ciniselli, Elisabetta Vergani, et al. "Alterations in Plasma Lipid Profiles Associated with Melanoma and Therapy Resistance." International Journal of Molecular Sciences 25, no. 3 (2024): 1558. http://dx.doi.org/10.3390/ijms25031558.

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Dysfunctions of lipid metabolism are associated with tumor progression and treatment resistance of cutaneous melanoma. BRAF/MEK inhibitor resistance is linked to alterations of melanoma lipid pathways. We evaluated whether a specific lipid pattern characterizes plasma from melanoma patients and their response to therapy. Plasma samples from patients and controls were analyzed for FASN and DHCR24 levels and lipidomic profiles. FASN and DHCR24 expression resulted in association with disease condition and related to plasma cholesterol and triglycerides in patients at different disease stages (n =

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30

Luu, Winnie, Eser J. Zerenturk, Ika Kristiana, Martin P. Bucknall, Laura J. Sharpe, and Andrew J. Brown. "Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis." Journal of Lipid Research 55, no. 3 (2013): 410–20. http://dx.doi.org/10.1194/jlr.m043257.

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31

Han, Fei, Qishan Chen, Jia Su, et al. "MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24." Journal of Molecular and Cellular Cardiology 132 (July 2019): 178–88. http://dx.doi.org/10.1016/j.yjmcc.2019.05.007.

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32

Battista, Marie-Claude, Marie-Odile Guimond, Claude Roberge, et al. "Inhibition of DHCR24/Seladin-1 impairs cellular homeostasis in prostate cancer." Prostate 70, no. 9 (2010): 921–33. http://dx.doi.org/10.1002/pros.21126.

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33

Frutos, Mario Fernández-de, Virginia Pardo-Marqués, Marta Torrecilla-Parra, et al. "“MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression”." Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1866, no. 2 (2023): 194938. http://dx.doi.org/10.1016/j.bbagrm.2023.194938.

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34

Mirza, R., S. Hayasaka, F. Kambe, et al. "Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice." British Journal of Dermatology 158, no. 4 (2008): 679–84. http://dx.doi.org/10.1111/j.1365-2133.2007.08424.x.

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Fuller, Peter J., Maria Alexiadis, Tom Jobling, and Jane McNeilage. "Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours." Clinical Endocrinology 63, no. 1 (2005): 111–15. http://dx.doi.org/10.1111/j.1365-2265.2005.02308.x.

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Fehér, Ágnes, Anna Juhász, Magdolna Pákáski, János Kálmán, and Zoltán Janka. "Gender dependent effect of DHCR24 polymorphism on the risk for Alzheimer's disease." Neuroscience Letters 526, no. 1 (2012): 20–23. http://dx.doi.org/10.1016/j.neulet.2012.08.010.

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Zhou, E., H. Nakashima, Z. Li та ін. "Δ24-Dehydrocholesterol reductase (DHCR24): A novel target for the treatment of nash". Atherosclerosis 315 (грудень 2020): e11. http://dx.doi.org/10.1016/j.atherosclerosis.2020.10.047.

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Kamigaki, Risa, Hiraku Kameda, Yui Shibayama, et al. "ODP037 Effects of DHCR24 Inhibitor on Excessive Adrenal Steroidogenesis in db/db mouse." Journal of the Endocrine Society 6, Supplement_1 (2022): A57. http://dx.doi.org/10.1210/jendso/bvac150.118.

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Abstract Background and purpose Patients with type 2 diabetes have an elevated basal level of cortisol, which has been suggested to be involved in the exacerbation of hyperglycemia and the progression of organ complications. Furthermore, it has been reported that adrenal steroidogenesis increases in db/db mice, an animal model of type 2 diabetes. However, the mechanism of the increased adrenal steroidogenesis in type 2 diabetes is unclear. In this study, we aimed to elucidate the mechanism of increased adrenal steroidogenesis in db/db mice and examine whether it is a therapeutic target. Experi

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James, Jasper E., Jacinta Santhanam, Richard D. Cannon, and Erwin Lamping. "Voriconazole Treatment Induces a Conserved Sterol/Pleiotropic Drug Resistance Regulatory Network, including an Alternative Ergosterol Biosynthesis Pathway, in the Clinically Important FSSC Species, Fusarium keratoplasticum." Journal of Fungi 8, no. 10 (2022): 1070. http://dx.doi.org/10.3390/jof8101070.

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Fusarium keratoplasticum is the Fusarium species most commonly associated with human infections (fusariosis). Antifungal treatment of fusariosis is often hampered by limited treatment options due to resistance towards azole antifungals. The mechanisms of antifungal resistance and sterol biosynthesis in fusaria are poorly understood. Therefore, in this study we assessed the transcriptional response of F. keratoplasticum when exposed to voriconazole. Our results revealed a group of dramatically upregulated ergosterol biosynthesis gene duplicates, most notably erg6A (912-fold), cyp51A (52-fold) a

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Hosseinzadeh, Soheila, Maryam Zahmatkesh, Mansour Heidari, et al. "Hippocampal DHCR24 down regulation in a rat model of streptozotocin-induced cognitive decline." Neuroscience Letters 587 (February 2015): 107–12. http://dx.doi.org/10.1016/j.neulet.2014.12.039.

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Zerenturk, Eser J., Laura J. Sharpe, Elina Ikonen, and Andrew J. Brown. "Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis." Progress in Lipid Research 52, no. 4 (2013): 666–80. http://dx.doi.org/10.1016/j.plipres.2013.09.002.

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Mirza, Rusella, Shanlou Qiao, Yoshiharu Murata, and Hisao Seo. "Requirement of DHCR24 for Postnatal Development of Epidermis and Hair Follicles in Mice." American Journal of Dermatopathology 31, no. 5 (2009): 446–52. http://dx.doi.org/10.1097/dad.0b013e318196f10c.

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Feher, A., A. Juhasz, A. Rimanoczy, J. Kalman, and Z. Janka. "P.1.a.018 Alzheimer's disease risk and polymorphisms of the DHCR24 gene." European Neuropsychopharmacology 20 (August 2010): S222—S223. http://dx.doi.org/10.1016/s0924-977x(10)70266-2.

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Ezzikouri, Sayeh, Kiminori Kimura, Hajime Sunagozaka, et al. "Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C." EBioMedicine 2, no. 6 (2015): 604–12. http://dx.doi.org/10.1016/j.ebiom.2015.04.007.

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Wang, Min, Guang‑Hua Luo, Hong Liu, et al. "Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways." Molecular Medicine Reports 19, no. 2 (2018): 1272–83. https://doi.org/10.3892/mmr.2018.9747.

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Capell-Hattam, Isabelle M., Laura J. Sharpe, Lydia Qian, Gene Hart-Smith, Anika V. Prabhu, and Andrew J. Brown. "Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally." Journal of Biological Chemistry 295, no. 9 (2020): 2850–65. http://dx.doi.org/10.1074/jbc.ra119.011323.

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Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well-understood. However, of the ∼20 enzymes in cholesterol biosynthesis, post-translational regulation has only been examined for a small number. Three of the four sterol reductases in cholesterol production, 7-dehydrocholesterol reductase (DHCR7), 14-dehydrocholesterol reductase (DHCR14), and lamin-B receptor (LBR), share evolutionary ties with a high level of sequence homology and predicted structural homology. DHCR14 and LBR u

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Ershov, Pavel, Leonid Kaluzhskiy, Yuri Mezentsev, Evgeniy Yablokov, Oksana Gnedenko, and Alexis Ivanov. "Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context." Biomedicines 9, no. 8 (2021): 895. http://dx.doi.org/10.3390/biomedicines9080895.

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A global protein interactome ensures the maintenance of regulatory, signaling and structural processes in cells, but at the same time, aberrations in the repertoire of protein–protein interactions usually cause a disease onset. Many metabolic enzymes catalyze multistage transformation of cholesterol precursors in the cholesterol biosynthesis pathway. Cancer-associated deregulation of these enzymes through various molecular mechanisms results in pathological cholesterol accumulation (its precursors) which can be disease risk factors. This work is aimed at systematization and bioinformatic analy

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Peng, Yuhao, Hongjuan Shi, Yuqi Liu, et al. "RNA Sequencing Analysis Reveals Divergent Adaptive Response to Hypo- and Hyper-Salinity in Greater Amberjack (Seriola dumerili) Juveniles." Animals 12, no. 3 (2022): 327. http://dx.doi.org/10.3390/ani12030327.

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Salinity significantly affects physiological and metabolic activities, breeding, development, survival, and growth of marine fish. The greater amberjack (Seriola dumerili) is a fast-growing species that has immensely contributed to global aquaculture diversification. However, the tolerance, adaptation, and molecular responses of greater amberjack to salinity are unclear. This study reared greater amberjack juveniles under different salinity stresses (40, 30, 20, and 10 ppt) for 30 days to assess their tolerance, adaptation, and molecular responses to salinity. RNA sequencing analysis of gill t

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Yang, Baoyu, Jing Mao, Shan Jiang, et al. "Cholesterol depletion induced by RNA interference targeting DHCR24 protects cells from liposome-induced cytotoxicity." Preparative Biochemistry & Biotechnology 49, no. 5 (2019): 453–58. http://dx.doi.org/10.1080/10826068.2019.1591979.

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Bonaccorsi, Lorella, Paola Luciani, Gabriella Nesi, et al. "Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer." Laboratory Investigation 88, no. 10 (2008): 1049–56. http://dx.doi.org/10.1038/labinvest.2008.80.

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