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1
Goluboff, Risa L. "What Makes Hartog Hartog: Introduction to a Symposium on the Work of Dirk Hartog." Law & Social Inquiry 44, no. 2 (May 2019): 491–97. http://dx.doi.org/10.1017/lsi.2019.15.
Повний текст джерелаАнотація:
The essays in this symposium on the work of Dirk Hartog encompass meditations on legal positivism and the histories of slavery, civil rights, and women’s rights as well as contemporary analyses of spousal abuse and the dependency of adult children. That wide range of subjects, approaches, and concerns might be puzzling were it not for the wide substantive, methodological, and theoretical range in Hartog’s own oeuvre. Hartog’s work has been so generative for other scholars because of his simultaneous engagement with history and law, with fact and theory, with the whole sweep of the nineteenth century and the most minute detail of a person’s life. In describing in this introduction what makes Hartog Hartog, I emphasize the unique blend of professional commitments and personal sensibilities he brings to his work: the sensitivity with which he approaches history; the humanity with which he treats his historical subjects; the dexterity with which he analyzes the law; and the sophistication with which his human and legal stories yield up jurisprudential insights. I also, respectfully, disagree with Hartog himself on the essence of his work. Where he laments that he exists in a “muddle in the middle”—writing histories of a problematic “inbetweenness”—I see him as making the messy lived reality of legal history cognizable to modern reader. His work reveals the simultaneity of multiple and overlapping legal regimes as they shaped and were shaped by the human needs of real people.
2
Cowen, Saul, Colleen Sims, Kym Ottewell, Fiona Knox, Tony Friend, Harriet Mills, Sean Garretson, Kelly Rayner, and Lesley Gibson. "Return to 1616: Multispecies Fauna Reconstruction Requires Thinking Outside the Box." Animals 13, no. 17 (August 30, 2023): 2762. http://dx.doi.org/10.3390/ani13172762.
Повний текст джерелаАнотація:
Conservation translocations have become increasingly popular for ‘rewilding’ areas that have lost their native fauna. These multispecies translocations are complex and need to consider the requirements of each individual species as well as the influence of likely interactions among them. The Dirk Hartog Island National Park Ecological Restoration Project, Return to 1616, aspires to restore ecological function to Western Australia’s largest island. Since 2012, pest animals have been eradicated, and conservation translocations of seven fauna species have been undertaken, with a further six planned. Here, we present a synthesis of the innovative approaches undertaken in restoring the former faunal assemblage of Dirk Hartog Island and the key learnings gathered as the project has progressed.
3
Algar, D., M. Johnston, C. Tiller, M. Onus, J. Fletcher, G. Desmond, N. Hamilton, and P. Speldewinde. "Feral cat eradication on Dirk Hartog Island, Western Australia." Biological Invasions 22, no. 3 (November 23, 2019): 1037–54. http://dx.doi.org/10.1007/s10530-019-02154-y.
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4
Maryan, Brad. "Herpetofauna of Dirk Hartog Island, Shark Bay area, Western Australia." Herpetofauna 26, no. 1 (June 1996): 8–11. https://doi.org/10.5962/p.418008.
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5
Bowdler, Sandra. "Before Dirk Hartog: Prehistoric Archaeoidgical Research in Shark Bay, Western Australia." Australian Archaeology 30, no. 1 (January 1990): 46–57. http://dx.doi.org/10.1080/03122417.1990.11681366.
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6
Wilson, Lucy, Richard van Dongen, Saul Cowen, and Todd P. Robinson. "Mapping Restoration Activities on Dirk Hartog Island Using Remotely Piloted Aircraft Imagery." Remote Sensing 14, no. 6 (March 14, 2022): 1402. http://dx.doi.org/10.3390/rs14061402.
Повний текст джерелаАнотація:
Conservation practitioners require cost-effective and repeatable remotely sensed data for assistive monitoring. This paper tests the ability of standard remotely piloted aircraft (DJI Phantom 4 Pro) imagery to discriminate between plant species in a rangeland environment. Flights were performed over two 0.3–0.4 ha exclusion plot sites, established as controls to protect vegetation from translocated animal disturbance on Dirk Hartog Island, Western Australia. Comparisons of discriminatory variables, classification potential, and optimal flight height were made between plot sites with different plant species diversity. We found reflectance bands and height variables to have high differentiation potential, whilst measures of texture were less useful for multisegmented plant canopies. Discrimination between species varied with omission errors ranging from 13 to 93%. Purposely resampling c. 5 mm imagery as captured at 20–25 m above terrain identified that a flight height of 120 m would improve capture efficiency in future surveys without hindering accuracy. Overall accuracy at a site with low species diversity (n = 4) was 70%, which is an encouraging result given the imagery is limited to visible spectral bands. With higher species diversity (n = 10), the accuracy reduced to 53%, although it is expected to improve with additional bands or grouping like species. Findings suggest that in rangeland environments with low species diversity, monitoring using a standard RPA is viable.
7
Tedeschi, J. N., N. J. Mitchell, O. Berry, S. Whiting, M. Meekan, and W. J. Kennington. "Reconstructed paternal genotypes reveal variable rates of multiple paternity at three rookeries of loggerhead sea turtles (Caretta caretta) in Western Australia." Australian Journal of Zoology 62, no. 6 (2014): 454. http://dx.doi.org/10.1071/zo14076.
Повний текст джерелаАнотація:
Female sea turtles are promiscuous, with clutches of eggs often sired by multiple males and rates of multiple paternity varying greatly within and across species. We investigated levels of multiple paternity in loggerhead sea turtles (Caretta caretta) from three rookeries in Western Australia by analysing polymorphic species-specific genetic markers. We predicted that the level of multiple paternity would be related to female population size and hence the large rookery at Dirk Hartog Island would have higher rates of multiple paternity than two smaller mainland rookeries at Gnaraloo Bay and Bungelup Beach. Contrary to our prediction, we found highly variable rates of multiple paternity among the rookeries that we sampled, which was unrelated to female population size (25% at Bungelup Beach, 86% at Gnaraloo Bay, and 36% at Dirk Hartog Island). Approximately 45 different males sired 25 clutches and the average number of sires per clutch ranged from 1.2 to 2.1, depending on the rookery sampled. The variance in rates of multiple paternity among rookeries suggests that operational sex ratios are variable in Western Australia. Periodic monitoring would show whether the observed patterns of multiple paternity for these three rookeries are stable over time, and our data provide a baseline for detecting shifts in operational sex ratios.
8
Driskell, Amy C., Stephen Pruett-Jones, Keith A. Tarvin, and Sarah Hagevik. "Evolutionary relationships among blue- and black-plumaged populations of the white-winged fairy-wren (Malurus leucopterus)." Australian Journal of Zoology 50, no. 6 (2002): 581. http://dx.doi.org/10.1071/zo02019.
Повний текст джерелаАнотація:
The white-winged fairy-wren (Malurus leucopterus) exhibits striking plumage colour variation between the Australian mainland and two islands (Dirk Hartog Island and Barrow Island) off the coast of Western Australia. Adult males on the mainland are bright blue with white wings and adult males on the two islands are black with white wings. To examine evolutionary relationships within this species, we sequenced 980 base pairs of two mitochondrial genes from 34 individuals from both islands and five mainland sites. Birds on Barrow Island were the most genetically distinct. Specimens from Dirk Hartog shared a unique character with, and were most similar to, birds from the Western Australian mainland. The black-and- white-plumaged subspecies from the two islands were not each other's closest relatives. Mapping of plumage evolution produced two equally parsimonious hypotheses: (1) black plumage arose from blue plumage convergently on the two islands, or (2) black plumage arose from blue plumage once and was followed by a re-evolution of blue plumage in mainland Western Australia birds. Levels of genetic differentiation in this species were low but genetic differentiation was discovered between morphologically identical eastern and western populations of the mainland subspecies, which is evidence for a current barrier to gene flow on mainland Australia.
9
Carter, Thomas. "Supplementary Notes on some Birds from Western Australia and from Dirk Hartog Island." Ibis 65, no. 2 (June 28, 2008): 218–28. http://dx.doi.org/10.1111/j.1474-919x.1923.tb08215.x.
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10
Reinhold, L., C. J. Limpus, D. J. Limpus, and A. U. Whiting. "Pivotal temperature of Loggerhead sea turtles, Caretta caretta, from Dirk Hartog Island, Western Australia." Memoirs of the Queensland Museum - Nature 60 (November 13, 2017): 161–71. http://dx.doi.org/10.17082/j.2204-1478.60.2017.2016-09.
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11
Algar, Dave, Keith Morris, John Asher, and Saul Cowen. "Dirk Hartog Island ‘Return to 1616’ Project – The first six years (2014 to 2019)." Ecological Management & Restoration 21, no. 3 (September 2020): 173–83. http://dx.doi.org/10.1111/emr.12424.
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12
Heriot, Shane, John Asher, Matthew R. Williams, and Dorian Moro. "The eradication of ungulates (sheep and goats) from Dirk Hartog Island, Shark Bay World Heritage Area, Australia." Biological Invasions 21, no. 5 (February 5, 2019): 1789–805. http://dx.doi.org/10.1007/s10530-019-01937-7.
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13
Dongen, Richard, Bart Huntley, Greg Keighery, and Mark Brundrett. "Monitoring vegetation recovery in the early stages of the Dirk Hartog Island Restoration Programme using high temporal frequency Landsat imagery." Ecological Management & Restoration 20, no. 3 (August 29, 2019): 250–61. http://dx.doi.org/10.1111/emr.12386.
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14
Short, J., and B. Turner. "The distribution and abundance of the burrowing bettong (Marsupialia : Macropoidea)." Wildlife Research 20, no. 4 (1993): 525. http://dx.doi.org/10.1071/wr9930525.
Повний текст джерелаАнотація:
The burrowing buttong (Bettongia lesueur) has been extinct on mainland Australia since the early 1960s, but was believed to persist on four islands off the coast of Western Australia-Bernier, Dorre, Barrow and Boodie. We surveyed these islands in 1988-89 to ascertain the status of bettongs and other endangered mammals. Bettongs were widespread and comparatively abundant on three islands but absent from the fourth. Bettongs occurred at estimated densities of c. 14-17km-2 on Bernier, Dorre and Barrow Islands, suggesting approximate minimum populations of 650, 1000 and 3400 respectively and a total minimum population for the species of c. 5000 individuals. It would appear that a poisoning campaign in 1985 to eliminate Rattus rattus from Boodie Island also eliminated the bettong. The burrowing bettong has apparently been absent from a fifth island and its type locality, Dirk Hartog Island in Shark Bay, since early this century. The vulnerability of this species is highlighted by its extinction on mainland Australia and by the loss of two of its five island populations. It now occupies less than 0.01% of its historical range. Its status as rare and endangered is justified.
15
Nieto-Blázquez, María Esther, Manuela Gómez-Suárez, Markus Pfenninger, and Katrin Koch. "Impact of feralization on evolutionary trajectories in the genomes of feral cat island populations." PLOS ONE 19, no. 8 (August 13, 2024): e0308724. http://dx.doi.org/10.1371/journal.pone.0308724.
Повний текст джерелаАнотація:
Feralization is the process of domesticated animals returning to the wild and it is considered the counterpart of domestication. Molecular genetic changes are well documented in domesticated organisms but understudied in feral populations. In this study, the genetic differentiation between domestic and feral cats was inferred by analysing whole-genome sequencing data of two geographically distant feral cat island populations, Dirk Hartog Island (Australia) and Kaho’olawe (Hawaii) as well as domestic cats and European wildcats. The study investigated population structure, genetic differentiation, genetic diversity, highly differentiated genes, and recombination rates. Genetic structure analyses linked both feral cat populations to North American domestic and European cat populations. Recombination rates in feral cats were lower than in domestic cats but higher than in wildcats. For Australian and Hawaiian feral cats, 105 and 94 highly differentiated genes compared to domestic cats respectively, were identified. Annotated genes had similar functions, with almost 30% of the divergent genes related to nervous system development in both feral groups. Twenty mutually highly differentiated genes were found in both feral populations. Evolution of highly differentiated genes was likely driven by specific demographic histories, the relaxation of the selective pressures associated with domestication, and adaptation to novel environments to a minor extent. Random drift was the prevailing force driving highly divergent regions, with relaxed selection in feral populations also playing a significant role in differentiation from domestic cats. The study demonstrates that feralization is an independent process that brings feral cats on a unique evolutionary trajectory.
16
Marsh, H., RIT Prince, WK Saafeld, and R. Shepherd. "The distribution and abundance of the dugong in Shark Bay, Western Australia." Wildlife Research 21, no. 2 (1994): 149. http://dx.doi.org/10.1071/wr9940149.
Повний текст джерелаАнотація:
In July 1989, dugongs were counted from the air at an overall sampling intensity of 7.9% over 14 239 km2 in Shark Bay, Western Australia. Counts were corrected for perception bias (the proportion of dugongs visible in the transect that are missed by observers), and standardised for availability bias (the proportion of animals invisible because of water turbidity) with survey-specific correction factors. The resultant minimum population estimate was 10146 � 1665 (s.e.) dugongs at an overall density of 0.71 � 0.12 (s.e.) dugongs km-2, the highest density ever recorded on a large-scale dugong survey. The proportion of calves (19%) was higher than for most other dugong surveys conducted in Shark Bay and elsewhere, suggesting an exceptionally high calving rate in 1988. Dugong density was highest (>5 km-2) in relatively deep water (12-16 m) in the eastern half of Shark Bay opposite the tip of Peron Peninsula and in the western Bay opposite the northern half of Dirk Hartog Island. Fewer than 4% of dugongs sighted in Shark Bay during the survey were in waters colder than 18�C. Results of aerial surveys over 906 km2 in the Faure Sill region of the eastern Bay in November 1990 and January 1991 suggest that between a third and a half of the dugongs in Shark Bay are located in this region during the summer. In contrast, only one dugong was sighted there during the winter survey. The survey confirms that Shark Bay is an internationally significant dugong habitat.
17
Hanifah, Aisyah Nur. "MENUMBUHKAN KEMBALI MINAT BELAJAR SEJARAH LOKAL PELABUHAN SENAPELAN PADA DIRI SISWA SMA MELALUI KARYA WISATA." Jurnal Pendidikan Sejarah Indonesia 4, no. 1 (June 16, 2021): 35. http://dx.doi.org/10.17977/um0330v4i1p35-48.
Повний текст джерелаАнотація:
The introduction of the Senapelan Harbor, as a part of history of the early birth of the city of Pekanbaru, to students is very important as part of a local history. To explore the historical story and the existence of Senapelan Harbor in the present, it is important for History teachers to introduce the port site through the field work learning method, accompanied by an android-based digital map media. The purposes of this study are (1) to determine how much knowledge high school students in Pekanbaru have about the historical sites of Senapelan Harbor. (2) to determine the effectiveness of the field trip method and digital maps in fostering the love of high school students for the local history of Senapelan Harbor. (3) to find out how much student achievement in learning local history has increased, by using the historical tourism work research method, based on digital maps.
18
Hardow, Dirk. "Neues Öl aus altem Kunststoff." CIRCULAR ECONOMY 43, no. 3 (2024): 22–23. http://dx.doi.org/10.51202/2943-3886-2024-3-022.
Повний текст джерелаАнотація:
Zirkularität in der Kunststoff- und Verpackungsindustrie lässt sich ebenso wenig wie die geforderten Rezyklateinsatzquoten ausschließlich mit mechanischem Recycling erreichen. Unternehmen der kunststofferzeugenden Industrie setzen daher verstärkt auf das chemische Recycling: Investitionen sollen von rund drei Milliarden Euro im Jahr 2025 auf über sieben Milliarden Euro bis 2030 steigen. Ein vielversprechendes Verfahren ist Carboliq. Seit Anfang 2024 gehört die Carboliq GmbH mehrheitlich dem Folienhersteller Südpack. Carboliq-Geschäftsführer Dirk Hardow erklärt das Verfahren.
19
Eguskiza, Naia, Iñaki Gaminde, and Aitor Iglesias. "Hizkuntza aldakortasunaz eta barietateen sailkapenez: aspektu ez-perfektuaren bariazioa Igorreko euskaran." Anuario del Seminario de Filología Vasca "Julio de Urquijo" 53, no. 1/2 (March 4, 2021): 163–81. http://dx.doi.org/10.1387/asju.22415.
Повний текст джерелаАнотація:
Hizkuntza aldakortasunaren ikerkuntzan barietateen zein informatzaileen sailkapenak egiterakoan metodo kuantitatibo objektiboen baliagarritasuna nabarmentzea da lan honen xedea. Horretarako, Igorreko hiztun gazteek aspektu ez-perfektua egiteko erabiltzen dituzten arau morfo-fonologikoak deskribatu eta aztertu dira. Sistema Konplexu Dinamiko Moldagarrien (SKDM) teoriari jarraiki, azaleko forma hutsen azterketatik harago, azterketa linguistikoaren beharra aldarrikatu ondoren, hiru teknika sailkatzaile erabili dira informatzaileak sailkatzekotan: multzokatze azterketa hierarkikoa, DAE metodoa eta K-batezbestekoen multzokatzea (KM) (logika lausoaren hatsarretan oinarritzen dena). Tekniken azalpenekin batera azterketa osoaren emaitzak ere aurkezten ditugu lanaren amaieran.
20
Bidegain, Eneko, and Gostin Andres. ""Eskualduna" astekariko kideak eta laguntzaileak." Euskera ikerketa aldizkaria 2, no. 65 (July 15, 2021): 363–400. http://dx.doi.org/10.59866/eia.v2i65.32.
Повний текст джерелаАнотація:
Dozenaka lagunek parte hartu zuten Eskualduna astekarian, gisa batez edo bestez. Orain arte agertutako izen zerrendatik harago, ez zen xehetasun handirik kide gehienei buruz. Kide horien sorterriak, sortegunak, lanak, lantokiak, karguak eta abar bildu dira lan honetan, laguntzaile bakoitzaren biografia txikia egiteko eta, bereziki, Eskualdunaren argazki xeheagoa egiteko. Astekariak Ipar Euskal Herri osoan zeuzkan laguntzaileak, eta asko ziren ardura politikoren bat zutenak.
21
Mildawati, Mildawati. "PEMAKNAAN LIVING QUR’AN DALAM TRADISI BAHUMA DI DESA SUNGAI HARANG, KABUPATEN HULU SUNGAI TENGAH." Muẚṣarah: Jurnal Kajian Islam Kontemporer 3, no. 1 (July 31, 2021): 43. http://dx.doi.org/10.18592/msr.v3i1.4962.
Повний текст джерелаАнотація:
The Qur'an is the primary guide for Muslims in dealing with various problems of life. The Qur'an is not only read and understood its meaning but also integrated into many social and cultural activities, even considered as something that must be done. The research method used is descriptive qualitative. The research subjects were the community and religious leaders of Sungai Harang Village. The results showed that the people of Sungai Harang always recite Al Fatihah, Al Ikhlas, An Falaq and An Nâs at every activity bahuma. The community interprets that the recitation is to get blessings, habl min al bi'ah and a means to get closer and ask for protection from Allah Al Qur’an adalah pedoman utama bagi umat Islam dalam menghadapi pelbagai problematika kehidupan. Al Qur’an tidak hanya sekedar dibaca dan dipahami maknanya, namun juga di integrasikan dalam banyak kegiatan sosial dan budaya, bahkan dianggap sebagai suatu hal yang harus dilakukan. Metode penelitian yang digunakan adalah deskriptif kualitatif. Subjek penelitian adalah masyarakat dan tokoh agama Desa Sungai Harang. Hasil penelitian menunjukkan bahwa masyarakat Sungai Harang selalu membaca surah Al Fatihah, Al Ikhlas, An Falaq serta An Nâs pada setiap kegiatan bahuma. Masyarakat memaknai bahwa pembacaan surah tersebut dalam rangka untuk mendapatkan berkah, habl min al bi’ah dan sarana mendekatkan diri dan memohon perlindungan kepada Allah
22
Mildawati, Mildawati. "PEMAKNAAN LIVING QUR’AN DALAM TRADISI BAHUMA DI DESA SUNGAI HARANG, KABUPATEN HULU SUNGAI TENGAH." Muẚṣarah: Jurnal Kajian Islam Kontemporer 3, no. 1 (July 31, 2021): 43. http://dx.doi.org/10.18592/msr.v3i1.4962.
Повний текст джерелаАнотація:
The Qur'an is the primary guide for Muslims in dealing with various problems of life. The Qur'an is not only read and understood its meaning but also integrated into many social and cultural activities, even considered as something that must be done. The research method used is descriptive qualitative. The research subjects were the community and religious leaders of Sungai Harang Village. The results showed that the people of Sungai Harang always recite Al Fatihah, Al Ikhlas, An Falaq and An Nâs at every activity bahuma. The community interprets that the recitation is to get blessings, habl min al bi'ah and a means to get closer and ask for protection from Allah Al Qur’an adalah pedoman utama bagi umat Islam dalam menghadapi pelbagai problematika kehidupan. Al Qur’an tidak hanya sekedar dibaca dan dipahami maknanya, namun juga di integrasikan dalam banyak kegiatan sosial dan budaya, bahkan dianggap sebagai suatu hal yang harus dilakukan. Metode penelitian yang digunakan adalah deskriptif kualitatif. Subjek penelitian adalah masyarakat dan tokoh agama Desa Sungai Harang. Hasil penelitian menunjukkan bahwa masyarakat Sungai Harang selalu membaca surah Al Fatihah, Al Ikhlas, An Falaq serta An Nâs pada setiap kegiatan bahuma. Masyarakat memaknai bahwa pembacaan surah tersebut dalam rangka untuk mendapatkan berkah, habl min al bi’ah dan sarana mendekatkan diri dan memohon perlindungan kepada Allah
23
KITLV, Redactie. "Book Reviews." New West Indian Guide / Nieuwe West-Indische Gids 69, no. 3-4 (January 1, 1995): 315–410. http://dx.doi.org/10.1163/13822373-90002642.
Повний текст джерелаАнотація:
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Paris: Autrement, 1994. 241 pp.-Michèle Baj Strobel, Solange Contour, Fort de France au début du siècle. Paris: L'Harmattan, 1994. 224 pp.-Betty Wood, Robert J. Stewart, Religion and society in post-emancipation Jamaica. Knoxville: University of Tennessee Press, 1992. xx + 254 pp.-O. Nigel Bolland, Michael Havinden ,Colonialism and development: Britain and its tropical colonies, 1850-1960. New York: Routledge, 1993. xv + 420 pp., David Meredith (eds)-Luis Martínez-Fernández, Luis Navarro García, La independencia de Cuba. Madrid: MAPFRE, 1992. 413 pp.-Pedro A. Pequeño, Guillermo J. Grenier ,Miami now! : Immigration, ethnicity, and social change. Gainesville: University Press of Florida, 1992. 219 pp., Alex Stepick III (eds)-George Irving, Alistair Hennessy ,The fractured blockade: West European-Cuban relations during the revolution. London: Macmillan Caribbean, 1993. xv + 358 pp., George Lambie (eds)-George Irving, Donna Rich Kaplowitz, Cuba's ties to a changing world. Boulder CO: Lynne Rienner, 1993, xii + 263 pp.-G.B. Hagelberg, Scott B. MacDonald ,The politics of the Caribbean basin sugar trade. New York: Praeger, 1991. vii + 164 pp., Georges A. Fauriol (eds)-Bonham C. Richardson, Trevor W. Purcell, Banana Fallout: Class, color, and culture among West Indians in Costa Rica. Los Angeles: UCLA Center for Afro-American studies, 1993. xxi + 198 pp.-Gertrude Fraser, George Gmelch, Double Passage: The lives of Caribbean migrants abroad and back home. Ann Arbor: University of Michigan Press, 1992. viii + 335 pp.-Gertrude Fraser, John Western, A passage to England: Barbadian Londoners speak of home. Minneapolis: University of Minnesota Press, 1992. xxii + 309 pp.-Trevor W. Purcell, Harry G. Lefever, Turtle Bogue: Afro-Caribbean life and culture in a Costa Rican Village. Cranbury NJ: Susquehanna University Press, 1992. 249 pp.-Elizabeth Fortenberry, Virginia Heyer Young, Becoming West Indian: Culture, self, and nation in St. Vincent. Washington DC: Smithsonian Institution Press, 1993. x + 229 pp.-Horace Campbell, Dudley J. Thompson ,From Kingston to Kenya: The making of a Pan-Africanist lawyer. Dover MA: The Majority Press, 1993. xii + 144 pp., Margaret Cezair Thompson (eds)-Kumar Mahabir, Samaroo Siewah, The lotus and the dagger: The Capildeo speeches (1957-1994). Port of Spain: Chakra Publishing House, 1994. 811 pp.-Donald R. Hill, Forty years of steel: An annotated discography of steel band and Pan recordings, 1951-1991. Jeffrey Thomas (comp.). Westport CT: Greenwood, 1992. xxxii + 307 pp.-Jill A. Leonard, André Lucrèce, Société et modernité: Essai d'interprétation de la société martiniquaise. Case Pilote, Martinique: Editions de l'Autre Mer, 1994. 188 pp.-Dirk H. van der Elst, Ben Scholtens ,Gaama Duumi, Buta Gaama: Overlijden en opvolging van Aboikoni, grootopperhoofd van de Saramaka bosnegers. Stanley Dieko. Paramaribo: Afdeling Cultuurstudies/Minov; Amsterdam: Koninklijk Instituut voor de Tropen, 1992. 204 pp., Gloria Wekker, Lady van Putten (eds)-Rosemarijn Hoefte, Chandra van Binnendijk ,Sranan: Cultuur in Suriname. Amsterdam: Koninklijk Instituut voor de Tropen/Rotterdam: Museum voor Volkenkunde, 1992. 159 pp., Paul Faber (eds)-Harold Munneke, A.J.A. Quintus Bosz, Grepen uit de Surinaamse rechtshistorie. Paramaribo: Vaco, 1993. 176 pp.-Harold Munneke, Irvin Kanhai ,Strijd om grond in Suriname: Verkenning van het probleem van de grondenrechten van Indianen en Bosnegers. Paramaribo, 1993, 200 pp., Joyce Nelson (eds)-Ronald Donk, J. Hartog, De geschiedenis van twee landen: De Nederlandse Antillen en Aruba. Zaltbommel: Europese Bibliotheek, 1993. 183 pp.-Aart G. Broek, J.J. Oversteegen, In het schuim van grauwe wolken: Het leven van Cola Debrot tot 1948. Amsterdam: Muelenhoff, 1994. 556 pp.''Gemunt op wederkeer: Het leven van Cola Debrot vanaf 1948. Amsterdam: Muelenhoff, 1994. 397 pp.
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Maciąg, Łukasz, Dominik Zawadzki, Gabriela A. Kozub-Budzyń, Adam Piestrzyński, Ryszard A. Kotliński, and Rafał J. Wróbel. "Mineralogy of Cobalt-Rich Ferromanganese Crusts from the Perth Abyssal Plain (E Indian Ocean)." Minerals 9, no. 2 (January 29, 2019): 84. http://dx.doi.org/10.3390/min9020084.
Повний текст джерелаАнотація:
Mineralogy of phosphatized and zeolitized hydrogenous cobalt-rich ferromanganese crusts from Dirck Hartog Ridge (DHR), the Perth Abyssal Plain (PAP), formed on an altered basaltic substrate, is described. Detail studies of crusts were conducted using optical transmitted light microscopy, X-ray Powder Diffraction (XRD) and Energy Dispersive X-ray Fluorescence (EDXRF), Differential Thermal Analysis (DTA) and Electron Probe Microanalysis (EPMA). The major Fe-Mn mineral phases that form DHR crusts are low-crystalline vernadite, asbolane and a feroxyhyte-ferrihydrite mixture. Accessory minerals are Ca-hydroxyapatite, zeolites (Na-phillipsite, chabazite, heulandite-clinoptilolite), glauconite and several clay minerals (Fe-smectite, nontronite, celadonite) are identified in the basalt-crust border zone. The highest Ni, Cu and Co contents are observed in asbolane and Mn-(Fe) vernadite. There is significant enrichment of Ti in feroxyhyte−ferrihydrite and vernadite. The highest rare earth element (REE) content is measured in the phosphate minerals, less in phyllosilicates and Na-phillipsite. The geochemical composition of minerals in the DHR crusts supports the formation of crusts by initial alteration, phosphatization and zeolitization of the substrate basalts followed by oscillatory Fe-Mn oxyhydroxides precipitation of hydrogenous vernadite (oxic conditions) and diagenous asbolane (suboxic conditions).
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Altuna Gabilondo, Larraitz. "Aire zabaleko Haur Hezkuntza balioztatzen." Tantak 35, no. 1 (February 4, 2024): 65–80. http://dx.doi.org/10.1387/tantak.23999.
Повний текст джерелаАнотація:
Azken urteetan Haur Hezkuntzako aire zabaleko ereduek sinesgarritasuna irabazi dute eta, zalantzarik gabe, naturaren onurak aldarrikatzetik joan dira bidea urratuz. Covid-19aren izurriteak osasuna erdigunera ekarri duelarik, aire zabaleko hezkuntzaren dohainak inoiz baino agerikoago egin zaizkigu. Mugimendu horren ondotik galdera berriak planteatu asmo ditu xede-esploratzailea duen idazki honek. Naturara itzultzea eta naturarekiko lotura beharra argudio sendoak dira eskolek ateak ireki ditzaten, eta hain beharrezko duten arnasa berria jaso dezaten. Baina, nahikoa al da naturak haurren hazkuntzan eragiten dituen onurez jardutea metodologia horiek balioztatzeko? Zer ebaluatu eta zertarako? Naturaren onurez harago joan nahi izan dugu, eta Haur Hezkuntzako haurren irteera-profilean eta hezkuntza-eskaintzan oinarritzen diren ebaluazio-ereduak eztabaidara ekarri. Balioztaze-ikuspegitik, “Onuragarria al da haurrak aire zabalean heztea?” galderatik hasi eta “Baso-eskola Haur Hezkuntzako haurren garapenerako berme osoko eredua al da?” formulaziora jo dugu, eta bien arteko jauzi kontzeptuala nabarmendu. Bigarrenak, haurrari eta ingurumenari ez ezik, eskola-esparruan gertatzen diren prozesuei eta eskaintzaren egiturazko alderdiei erreparatuko die.
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Padilla-Moyano, Manuel. "Ohar bat Zuberoako bokal asimilazioen kronologiaz." Anuario del Seminario de Filología Vasca "Julio de Urquijo" 57, no. 1-2 (January 29, 2025): 773–83. https://doi.org/10.1387/asju.25925.
Повний текст джерелаАнотація:
Zuberoa osoan obratu ziren bokalen arteko elkarreraginez harago (hots, konbentzio ordinarioan [e + a > ia], [o + a > ua] & [ü + a > ia] arauetan adierazten direnak), une batetik aitzina bokal asimilazio deitu ohi diren aldaketa berriagoak abiatu ziren, arras modu sinplifikatuan [í + a > í] & [ú + a > ú] bezala formula daitezkeenak. Egun, aldaketa bigarrendar horiek zubereraren barneko desberdintasun markagarrienetarik dira, beharbada ezaugarri intradialektal nagusi. Lan honek Zuberoako bokal asimilazioen kronologia du jomuga. Gaiaz dakiguna bildurik (§ 1), Zuberoako testu zaharren lekukotza ekarriko dugu (§ 2), eta egungo hizkuntzatik hurbil diren datuak aztertuko ditugu (§ 3). Ondoren, asimilazio bokalikoen kronologiaz eta hedaduraz arituko gara (§ 4), ondorio batera etortzeko (§ 5).
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Ariztimuño Lopez, Borja. "SENI eta LOHI (sudurkari galduaren bila) / SENI & LOHI (in search of lost nasal)." Anuario del Seminario de Filología Vasca "Julio de Urquijo" 52, no. 1/2 (January 8, 2019): 19. http://dx.doi.org/10.1387/asju.20191.
Повний текст джерелаАнотація:
Artikulu honek Koldo Mitxelenaren lanez geroztiko berreraiketan (bai eta Mitxelenaren beraren etimologia batzuetan ere) azaltzeke utzi diren zenbait eretzi heltzen die, Akitaniako SENI eta LOHI lekukotasunen bitartez. Alde batetik, sudurkaritasun arrastorik utzi ez duten bokalarteko *n-ak ditugu eta, bestetik, segmentu beraren bilakaeraren xehetasunak, arauaren ezarpenari eta kronologia erlatiboari dagokienez, antzinako konposozio-arauekiko harremana ere kontuan harturik (cf. Igartua 2002). Eztabaidagai horiek erro monosilabikoaren teoriaren barruan (Lakarra 1995 hh) garaturiko etimologia batzuk kolokan jar litzakete, eta areago teoria hankamotz utzi, bisilabo zahar zenbaiten eratorri izaera sistema-eskakizunez harago justifikatu ezean. Hemen, oztopo horiek gainditzeko (eta gainditu beharraren erakusgarri), bi hitz-familia berri proposatzen dira: zahi/zain eta behe/mehe bikoteek osaturikoak.
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Widodo, Yoga Wicaksono Putra, and Tri Kurniawati Ambarini. "A Case Study: Empty Chair Therapy for A Survivor of Suicide with Depression with Psychotic." Psikoborneo: Jurnal Ilmiah Psikologi 12, no. 2 (June 10, 2024): 205. http://dx.doi.org/10.30872/psikoborneo.v12i2.14685.
Повний текст джерелаАнотація:
Suicide survivors are families or close relatives who experienced the loss of a loved one due to suicide. Survivors need time to process grief longer than the others due to the lingering guilt related to the 'failure' to save the suicide victim. One of the psychiatric disorders that appears comorbid with this grief is major depression, especially major depression with psychosis. This research is a case study of how empty chair therapy can be applied to suicide survivors who experience depression with psychosis. The results showed that empty chair therapy was able to help participants identify the source of unfinished business which caused participants to feel guilty and harbor it, risking one to suicidal ideation and auditory hallucinations. Empty chair therapy was also able to facilitate participants to channel feelings of guilt and help gain a new perspective on the situation through changing roles in therapy.Penyintas bunuh diri merupakan anggota keluarga atau teman dekat yang mengalami kehilangan sosok yang dicintai akibat bunuh diri. Penyintas membutuhkan waktu untuk memproses kedukaan lebih lama daripada sosok lainnya akibat rasa bersalah yang berkaitan dengan ‘kegagalan’ menyelamatkan sosok terkait. Salah satu gangguan psikiatri yang muncul komorbid dengan kedukaan ini adalah depresi mayor, terkhusus depresi mayor dengan psikotik. Penelitian ini merupakan studi kasus penerapan terapi kursi kosong pada penyintas bunuh diri yang mengalami depresi dengan psikotik melalui single case method dengan desain penelitian A-B yang mengukur perbedaan perilaku sebelum dan sesudah intervensi.. Hasil menunjukkan bahwa terapi kursi kosong mampu membantu partisipan untuk mengidentifikasi sumber unfinished business yang menyebabkan partisipan merasa bersalah dan memendamnya sehingga memunculkan ide bunuh diri dan halusinasi auditori. Terapi kursi kosong juga mampu memfasilitasi partisipan untuk menyalurkan perasaan bersalah dan membantu mendapatkan perspektif baru dari situasi tersebut melalui perubahan peran dalam terapi.
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Diah, Diah Ramadhani, Dedy Sumardi, and Edi Yuhermansyah. "PENYELESAIAN SENGKETA HARATO PUSAKO TINGGI OLEH LEMBAGA KERAPATAN ADAT NAGARI DALAM PERSPEKTIF SIYASAH DUSTURIYAH." As-Siyadah 3, no. 1 (April 28, 2024): 44–61. https://doi.org/10.22373/as-siyadah.v3i1.3819.
Повний текст джерелаАнотація:
Tanah Pusako Tinggi di dalam Adat Minangkabau merupakan bagian dari harta pusako tinggi yang diwarisi secara turun temurun dari Niniak kepada Mamak dan dari Mamak kepada Kamanakan. Pembagian tanah pusako tinggi dikenal dengan istilah Ganggam Bauntuak yang berarti diturunkan berdasarkan pertalian darah seketurunan ibu dan dikuasai dengan hak kolektif bersama dalam suatu kaum. Penguasaan dan pengelolaan tanah pusako tinggi beresiko menimbulkan sengketa yang terjadi di dalam ataupun diluar kaum. Berkaitan dengan ini, Kerapatan Adat Nagari berperan sebagai lembaga peradilan adat untuk menyelesaikan berbagai persengketaan yang diajukan oleh masyarakat nagari melalui jalan musyawarah untuk mencapai mufakat perdamaian. Penelitian ini mengkaji bagaimana mekanisme penyelesaian sengketa harato pusako tinggi oleh lembaga Kerapatan Adat Nagari Limau Purut dan bagaimana tinjauan Fiqh Siyasah Dusturiyah terhadap putusan dari Kerapatan Adat Nagari Limau Purut dalam menyelesaikan sengketa harato pusako tinggi. Metode penelitian yang digunakan adalah Yuridis Sosiologis dengan jenis Kualitatif. Berdasarkan hasil penelitian diambil kesimpulan bahwa penyebab terjadinya sengketa tanah pusako tinggi antara pihak A Cs sebagai penggugat dengan pihak BH Cs sebagai tergugat adalah karena adanya pengajuan permohonan untuk pengeluaran surat kepemilikan tanah atas nama BH Cs kepada KAN Limau Purut diatas tanah yang sudah dihibahkan oleh leluhur dari pihak penggugat A Cs. Pihak A Cs merasa hibah tersebut tidak sah karena tidak adanya pembuktian yang kuat menurut kesaksian kaumnya, sementara itu pihat tergugat A Cs melampirkan bukti surat tebus gadai dan hibah sebagai pembelaan diri. Mekanisme penyelesaian sengketa ini dilaksanakan sesuai dengan ketentuan adat bajanjang naiak batanggo turun dengan upaya putusan perdamaian berdasarkan adaik basandi syara’, syara’ basandi kitabullah yang mengacu pada konsep Islam fiqh siyasah dusturiyah dalam pengambilan putusan berpedoman dengan kaidah-kaidah Siyasah Dusturiyah yakni merundingkan, mengaktualisasikan, dan memberlakukan putusan.
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Pébarthe, Christophe. "Jean-Pierre Vernant et le mythe hésiodique des races. Essai d’analyse sociologique." Revue des Études Anciennes 118, no. 2 (2016): 529–51. http://dx.doi.org/10.3406/rea.2016.6787.
Повний текст джерелаАнотація:
Dans sa dernière livraison (n° 218, 2016), la revue L’Homme consacre notamment deux articles aux analyses fameuses que Jean-Pierre Vernant a naguère consacrées au mythe hésiodique des races. Le premier, «Jean-Pierre Vernant et l’analyse structurale. Le mythe hésiodique des races » , rédigé par Aurélien Gros, qui a récemment soutenu une thèse le 7 mars 2015 sous la direction de François Hartog et intitulée L’anthropologie historique de Jean‑Pierre Vernant. Enquête épistémologique, tente d’expliquer comment l’helléniste articulait de manière originale la psychologie historique d’Ignace Meyerson et l’anthropologie structurale de Claude Lévi-Strauss. Cette articulation serait à l’origine de l’anthropologie historique. Le second, «Le mythe hésiodique des races, oeuvre de langage. Jean‑Pierre Vernant et après » , écrit par Pierre Judet de La Combe, souligne l’intérêt qu’il y a à intégrer une dimension pragmatique à cette analyse structurale du mythe, c’est-à-dire à considérer l’intervention singulière d’Hésiode sur le matériau mythique. Or, lorsque sont rappelés le contexte intellectuel et académique des années 1950 et 1960 et les principes de l’analyse structurale lévi-straussienne des mythes, le rapport de Jean-Pierre Vernant au structuralisme apparaît comme critique. Derrière son «Essai d’analyse structurale » , l’helléniste proposait en réalité une démarche différente de celle de Claude Lévi-Strauss. À l’aune de ce qui apparaît surtout comme une analyse sociologique, le mythe des races, tout autant rapporté que composé par Hésiode, témoigne d’un temps présent conçu comme indéterminé duquel le poète tente de faire surgir un ordre, celui de la justice (dikê), dans un récit mythique rendant compte de la genèse et de la structure de son monde social.
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Jasko, Katarzyna, David Webber, Erica Molinario, Arie W. Kruglanski, and Katharine Touchton-Leonard. "Ideological Extremism Among Syrian Refugees Is Negatively Related to Intentions to Migrate to the West." Psychological Science 32, no. 9 (August 26, 2021): 1362–74. http://dx.doi.org/10.1177/0956797621996668.
Повний текст джерелаАнотація:
The conflict in Syria created a dire humanitarian situation, as nations around the world struggled with how best to deal with the more than 6.6 million Syrian refugees who fled their homes to escape aggression. Resistance to granting refugee status to individuals often originates in the belief that the influx of refugees endangers national security because of the presumably extremist religious and political beliefs that refugees hold. The present research surveyed Syrian refugees residing in Jordan, Lebanon, Turkey, and Iraq ( N = 1,000). The results revealed that the majority of surveyed refugees did not intend to migrate to the West and would rather return to their home country. More importantly, refugees most interested in moving to Western countries were the least likely to subscribe to Islamist extremism or to harbor negative sentiment toward the West. Theoretical and practical implications for addressing the current refugee crisis are discussed.
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Alguzo, Nouh. "Dreams Turned into Nightmares: Reimagining the American Dream in John Steinbeck’s Of Mice and Men." Steinbeck Review 21, no. 2 (December 2024): 176–91. https://doi.org/10.5325/steinbeckreview.21.2.0176.
Повний текст джерелаАнотація:
Abstract In John Steinbeck’s Of Mice and Men, the American Dream of material success and economic stability is interpreted as a nightmare devoid of reality. The existential concerns of the ranch workers in this novel and their dire poverty shatter their faith in its seemingly unattainable ideals. Throughout this narrative, Steinbeck suggests that this Dream has transformed into a horror for diligent workers who harbor little optimism about achieving their aspirations in a violent and morally corrupt society. Marxist critics, among others, view the American Dream skeptically, arguing that it suppresses the awareness of the lower classes by attributing their failures to laziness, thus perpetuating their exploitation by capitalists. The characters’ harsh existence in Steinbeck’s narrative dismantles the widely held belief that hard work inevitably leads to success, prompting skeptics to question the validity of this national promise of prosperity, home ownership, and job security.
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Ma, Rosanna K., Pei-Yin Tsai, Alaa R. Farghli, Alexandria Shumway, Matt Kanke, John D. Gordan, Taranjit S. Gujral, et al. "DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma." PLOS Genetics 20, no. 3 (March 21, 2024): e1011216. http://dx.doi.org/10.1371/journal.pgen.1011216.
Повний текст джерелаАнотація:
Fibrolamellar carcinoma (FLC) is a rare liver cancer that disproportionately affects adolescents and young adults. Currently, no standard of care is available and there remains a dire need for new therapeutics. Most patients harbor the fusion oncogene DNAJB1-PRKACA (DP fusion), but clinical inhibitors are not yet developed and it is critical to identify downstream mediators of FLC pathogenesis. Here, we identify long noncoding RNA LINC00473 among the most highly upregulated genes in FLC tumors and determine that it is strongly suppressed by RNAi-mediated inhibition of the DP fusion in FLC tumor epithelial cells. We show by loss- and gain-of-function studies that LINC00473 suppresses apoptosis, increases the expression of FLC marker genes, and promotes FLC growth in cell-based and in vivo disease models. Mechanistically, LINC00473 plays an important role in promoting glycolysis and altering mitochondrial activity. Specifically, LINC00473 knockdown leads to increased spare respiratory capacity, which indicates mitochondrial fitness. Overall, we propose that LINC00473 could be a viable target for this devastating disease. Schematic was created with BioRender.com.
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CAPDEFERRO VILLAGRASA, OSCAR. "GESTION DE RIESGOS EN EL PLAN DE RECUPERACION, TRANSFORMACION Y RESILIENCIA: LA PREVENCION DE LOS CONFLICTOS DE INTERESES." Pertsonak eta Antolakunde Publikoak kudeatzeko Euskal Aldizkaria / Revista Vasca de Gestión de Personas y Organizaciones Públicas, no. 26-II (November 1, 2024): 68–81. http://dx.doi.org/10.47623/ivap-rvgp.26.2024.ab.04.
Повний текст джерелаАнотація:
Desde 2021, en España se han establecido medidas para la gestión íntegra de los fondos europeos, y, especialmente, se ha potenciado la actuación de control preventiva, mediante planificación basada en análisis de riesgos, declaraciones personales de ausencia de conflicto de intereses antes de intervenir y análisis automatizados para detectar posibles casos de corrupción. Se trata de medidas que suponen un avance en la lucha contra la corrupción en España, aunque algunas cuestiones negativas son destacables, y pueden tenerse en cuenta en el futuro, para mejorar estos mecanismos y eventualmente aplicar su uso más allá de la gestión de fondos europeos, una vez finalizado el Plan de Recuperación, Transformación y Resiliencia (PRTR). 2021az geroztik, Espainian neurriak ezarri dira Europako funtsak osorik kudeatzeko eta, bereziki, prebentzio-kontroleko jarduera bultzatu da, arrisku-analisian oinarritutako plangintzaren bidez, esku hartu aurretik interes-gatazkarik ez dagoela adierazteko azalpen pertsonalen bidez, eta balizko ustelkeria-kasuak detektatzeko analisi automatizatuen bidez. Espainian ustelkeriaren aurkako borrokan aurrera egitea dakarten neurriak dira, nahiz eta gai negatibo batzuk nabarmen samarrak diren, baina baliagarri izan daitezke, etorkizunerako kontuan hartu, mekanismo horiek hobetzeko eta, agian, horien erabilera Europako funtsen kudeaketatik harago aplikatzeko, Suspertze, Eraldatze eta Erresilientzia Plana (SEEP) amaitu ondoren. Since 2021, measures have been established in Spain for the correct management of European funds, and, especially, preventive control actions have been enhanced, through planning based on risk analysis, personal declarations of absence of conflict of interest before intervening and automated analysis to detect possible cases of corruption. These measures represent a step forward in the fight against corruption in Spain, although some negative issues are noteworthy and can be taken into account in the future, in order to improve these mechanisms and eventually apply their use beyond the management of European funds, once the Recovery, Transformation and Resilience Plan (PRTR) is ended.
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Altuna, Jon, Alba Madinabeitia, Inazio Marko, Ana Aierbe, and Esther Cruz. "EHUko Pedagogia Gradua lanbide anitzetarako prestatzen: ikasleen asebete eta iritzietan eta irakasleen pertzepzioan oinarritutako analisia." Tantak 32, no. 2 (February 6, 2021): 51–74. http://dx.doi.org/10.1387/tantak.21899.
Повний текст джерелаАнотація:
Unibertsitatea da herritarren formakuntzan eta profesionalizazioan hezkuntza-instituzio aitzindaria, eta horregatik Pedagogia Graduari eginkizun garrantzitsu horretan prestakuntzaren kalitateari buruz hausnartzea egokitzen zaio. Pedagogoaren lanbideak badu berezitasun bat: hezkuntzako aditu gisa, tradizioz eskola-testuingurura mugatu izan du bere jarduna baina hezkuntza formaletik harago espazio potentzial ugari ditu. Horrekin batera, ordea, bere lekua mu- gatzeko zailtasuna agerikoa da. Hortaz, xxi. mendeko pedagogiari dagokio bere lan-esparrua birdefinitzea eta formakun- tza orientatzeko erronka. Artikulu honen helburu orokorra izan da Euskal Herriko Unibertsitateko (UPV/EHU) Pedagogia Graduko ikasleek eta irakasleek, profesionalizazioaren mapan zehatutako lan-arloak kontuan hartuz zenbateraino haute- maten duten koherentea dela graduan eskaintzen den prestakuntza aztertzea. Lagina 131koa izanik, Pedagogia Graduko 4. mailako 83 ikaslek eta gradu bereko 48 irakaslek parte hartu eta Likert eskaladun galdetegia bete dute. Ikasleen beharrak abiapuntu hartuta azterlan deskribatzaile eta esploratzailea burutu da. Emaitzek erakusten dutenez, ikasleen balorazioa ira- kasleena baino baxuagoa da pedagogiako irakasgaiak pedagogoaren lanbide-irteeretan duten posizioari begiratzen bazaio, eta bien ustez, jasotako prestakuntzan zein lan munduan errepresentazio handiena duen eremua «Ikerketa eta Hezkuntza» da. Aldiz, «Gizartea eta Kultura» eta «Prestakuntza eta Enpresa» gutxien ordezkatutakoak dira. Emaitza hauek orientabi- deak ematen dituzte etorkizunean Pedagogia Graduaren hobekuntzan eta pedagogoaren lanbide-profilaren zehaztasunean aurrera egiteko.
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Mlinac-Jerkovic, Kristina, Svjetlana Kalanj-Bognar, Marija Heffer, and Senka Blažetić. "Methodological Pitfalls of Investigating Lipid Rafts in the Brain: What Are We Still Missing?" Biomolecules 14, no. 2 (January 28, 2024): 156. http://dx.doi.org/10.3390/biom14020156.
Повний текст джерелаАнотація:
The purpose of this review is to succinctly examine the methodologies used in lipid raft research in the brain and to highlight the drawbacks of some investigative approaches. Lipid rafts are biochemically and biophysically different from the bulk membrane. A specific lipid environment within membrane domains provides a harbor for distinct raftophilic proteins, all of which in concert create a specialized platform orchestrating various cellular processes. Studying lipid rafts has proved to be arduous due to their elusive nature, mobility, and constant dynamic reorganization to meet the cellular needs. Studying neuronal lipid rafts is particularly cumbersome due to the immensely complex regional molecular architecture of the central nervous system. Biochemical fractionation, performed with or without detergents, is still the most widely used method to isolate lipid rafts. However, the differences in solubilization when various detergents are used has exposed a dire need to find more reliable methods to study particular rafts. Biochemical methods need to be complemented with other approaches such as live-cell microscopy, imaging mass spectrometry, and the development of specific non-invasive fluorescent probes to obtain a more complete image of raft dynamics and to study the spatio-temporal expression of rafts in live cells.
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An, Shanshan, Xiaoxiao Zhang, Yunfan Shi, Jiaming Zhang, Yulin Wan, Yuchuan Wang, Ying Zhang, and Qiuyun Liu. "High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy." Journal of International Medical Research 48, no. 6 (June 2020): 030006052092985. http://dx.doi.org/10.1177/0300060520929853.
Повний текст джерелаАнотація:
Numerous risk factors for heart disease or dementia harbor over 10% valine plus glycine content. Interestingly, TDP-43 contains 6.0% valine and 13.3% glycine, and the buildup of this protein in the brains of patients with limbic-predominant age-related TDP-43 encephalopathy has dire consequences. The two γ-methyl groups in valine enable hyperconjugation, which enhances the van der Waals interaction between its side group and the carbonyl carbon. This extends the C=O bond length, and this weakened C=O bond augments the secondary chemical bonding of the carbonyl oxygen atom to cations. This, in turn, promotes the formation and buildup of insoluble and rigid salts such as calcium oxalate, which is postulated to be a major cause of heart disease. Similarly, the long C=O bond length in glycine results in a weakened C=O bond with an enhanced affinity toward cations and the formation of insoluble salts. Further, several prion proteins possess a high glycine content of approximately 20%. The insoluble calcium salts produced may promote aggregate formation via secondary chemical bonding between calcium and glycine, as well as between calcium and valine. Chemical and biochemical insights will help us to better understand the etiology of disorders linked to protein aggregates.
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Thacker, Mital, and Balasubramanian Karthick. "Response of Diatoms to the Changing Water Quality in the Myristica Swamps of the Western Ghats, India." Diversity 14, no. 3 (March 9, 2022): 202. http://dx.doi.org/10.3390/d14030202.
Повний текст джерелаАнотація:
Myristica swamps are one of the rarest wetland ecosystems within the sub-tropical evergreen forests of the Western Ghats, India. As their name indicates, they harbor trees belonging to the ancient family Myristicaceae. Due to the waterlogged conditions and high humic decomposition, these swamps are acidic, harbor rare and endemic biotas, and provide ecosystem services to humans. Monitoring this rare ecosystem is crucial because the swamps that once formed a large hydrological network across the Western Ghats are now confined to isolated patches due to human disturbance such as agricultural interventions, roads, and dam construction. Due to the change in land use, there is also a drastic change in water chemistry and associated biodiversity. Biomonitoring is more precise than physical and chemical monitoring. So, the current study aimed to undertake a comprehensive analysis of the physical, chemical, and biological assessment of these swamps. The diatom assemblages are strongly affected by water chemistry and serve as a powerful indicator of environmental changes in the freshwater aquatic systems. However, there is no information on diatom assemblages in these swamps, and the present study aimed to determine the diatom assemblage structure in the Myristica swamps and their response to changing water quality. Diatom samples were taken at 17 different swamps across the central Western Ghats, and a set of environmental parameters was evaluated. Analysis revealed a total of 91 species of diatoms belonging to 27 genera across the 17 sites, from which 44 diatom species showed restricted distribution to this unique environment. Overall, the dominant diatom genera inside the swamps included, Navicula (19.8%), Gomphonema (16%), Eunotia (13.3%), Ulnaria (9.4%), Achnanthidium (8%), Frustulia (6.2%), Planothidium (5.2%), and Brachysira (2.8%). High diatom species richness was observed in the swamps having less anthropogenic disturbance, and diatom assemblage composition was primarily determined by dissolved oxygen, pH, and conductivity. The significant number of geographically restricted taxa in this study points towards our limited understanding of this tropical biome and calls for a dire need for more studies from here, not only to improve our knowledge concerning the diversity, ecology, and biogeography of these diatoms but to further encourage their use in applied (paleo) environmental sciences. Our results indicate that diatoms can prove useful environmental indicators even in harsh environments like swamps and can be a potential tool for assessing ecological and climatic change.
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Li, Yang, Daniel J. McGrail, Sharad Awasthi, S. Stephen Yi, Mark T. Bedford, and Nidhi Sahni. "Abstract LB182: Targeting arginine methylation for improved therapy in triple negative breast cancer." Cancer Research 83, no. 8_Supplement (April 14, 2023): LB182. http://dx.doi.org/10.1158/1538-7445.am2023-lb182.
Повний текст джерелаАнотація:
Abstract Since the discovery of DNA repair deficiency as risk factors for breast cancer, our knowledge of their function in maintaining human genomic integrity and a normal biological function has greatly advanced, ultimately culminating in development of PARP inhibitors that can specifically target patients who harbor these mutations. However, to date PARP inhibitors have demonstrated only modest clinical success as monotherapy in triple-negative breast cancer. In addition, conventional therapies are often coupled with severe toxicity. Therefore, there is a dire need to develop more effective combination therapies. Although there are many existing tools to predict possible actionable targets, it remains challenging to effectively and systematically identify drug combinations for better breast cancer therapeutics. This is because most tumors carry multiple genetic alterations that cannot be suppressed with mono-therapies; and diverse confounding factors such as intra-tumor and inter-tumor heterogeneity exist across patient populations. Our preliminary proteomics study has revealed a new protein mark called arginine methylation as a novel target for breast cancer. We found that inhibition of arginine methylation can sensitize cancer cells for PARP inhibition treatment. We further assessed and validated this actionable and synergistic drug combination in patient-derived xenograft models. Together, our novel target combinations discovered here may serve as important biomarkers to help develop more effective combination therapy. Furthermore, our results help uncover patient-specific signaling mechanisms, a critical step towards precision medicine in breast cancer therapy, which is a benefit and potential long-term outcome. Citation Format: Yang Li, Daniel J. McGrail, Sharad Awasthi, S. Stephen Yi, Mark T. Bedford, Nidhi Sahni. Targeting arginine methylation for improved therapy in triple negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB182.
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Dr. Shahid Abbas, Dr. Ijaz Asghar, and Qamar Hussain. "Analyzing George Bernard Shaw’s Portrayal of Women in the Light of Postfeminist Theory." sjesr 4, no. 2 (July 3, 2021): 438–43. http://dx.doi.org/10.36902/sjesr-vol4-iss2-2021(438-443).
Повний текст джерелаАнотація:
The paper aims at investigating the critical opinions about Bernard Shaw’s ambivalent relation to feminism. In this regard, the researchers highlight the emerging role of postfeminism and its overlapping elements with the Islamic portrayal of womanhood. Shaw differs from his predecessors drastically – he portrays independent female characters as compared to the invisible and submissive females of the past. Thus, one of the striking features of Shaw’s drama is the depiction of liberated women. The Shavian women do not consider men folk as their rivals. There is a shift from powerless to empowered women in academia. The researchers find out that there is an ideological conflict between feminism and Islam but as far as postfeminism is concerned, there is none. Rather, postfeminism propagates and supports the Islamic concept of womanhood thoroughly. It is also worth noting that feminist ideas and ideology have greatly dented the social and political fabric of mankind and human civilization in general. Whereas, postfeminism propagates in favor of maintaining a balanced position for womanhood in life which is a balance between social and individual life, and a balance between professional and family life. The purpose of this article is to promote a better understanding of the status of women in Islam and its overlapping and common areas with postfeminism, that is, God has equated female folk at par with their male folk. The research is significant as it challenges the western notion of women in Islam and dispels the erroneous notions of suppression of women in Islam. The prime finding of this research is that postfeminism proclaims equal footing for men and women in life, as enshrined in the Holy Quran. Further, the researchers lament that just because of myopic-minded people, the world is not making any progress intellectually. The researchers recommend that there is a dire need to promote liberal intellectuals like Shaw who harbor no bias against Islam and Muslims to maintain peace and order in the world.
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Treger, Taryn D., Jenny Wegert, Anna Wenger, Tim H. H. Coorens, Reem Al-Saadi, Paul Kemps, Jonathan Kennedy, et al. "Abstract PR002: Somatic genetic development of Wilms tumor via normal kidneys in predisposed children." Cancer Research 84, no. 17_Supplement (September 5, 2024): PR002. http://dx.doi.org/10.1158/1538-7445.pediatric24-pr002.
Повний текст джерелаАнотація:
Abstract Ten percent of children with cancer harbor a predisposition mutation, and in children with the kidney cancer, Wilms tumor, the prevalence may be as high as 30%. Whilst clinical management of children with a known predisposition differs from that of children with sporadic Wilms tumors, it is not dependent on the type of predisposition. Some Wilms predispositions are associated with defined histological and clinical features, which suggests differences in the genetic development of such tumors. To investigate this, we assembled a cohort of 137 children with Wilms tumor, of whom 71 were found to have an underlying pathogenic germline or mosaic predisposition variant. Predisposition changes encompassed methylation changes, substitutions, indels, simple rearrangements and more complex ones. Our multi-omic approach detected four novel putative Wilms tumor predisposition genes, and identified causative predisposition variants in children where standard of care assays had failed to do so. We reconstructed the development of 237 neoplasms from zygote via normal kidney tissue, utilizing whole genome sequencing, RNA sequencing and genome wide methylation data, and pursued our findings in an independent validation cohort. We found that tumor development differed between predisposed and sporadic cases, and varied amongst predisposed children according to specific mutations and their developmental timing. These differences pervaded the clonal architecture of normal kidneys, and the repertoire of driver events, such as the possibility of acquiring high risk disease variants. A striking absence of additional driver variants were, in particular, noted for WT1 and TRIM28 predisposed tumors. In 20 children we examined the relationship between multiple neoplasms, including bilateral tumors, recurrences, metastases, and leukemias. The tumors from non-predisposed children shared a common tumor trunk, whereas we in many predisposed children saw an extraordinary propensity for independent tumor generation. In conclusion, we examined the somatic evolution of Wilms tumor via normal kidney tissue in predisposed children, and showed that predisposition variants may constrain the somatic genetic development of Wilms tumor. Our findings suggest that a variant specific approach to the clinical management of these children may merit consideration. Citation Format: Taryn D. Treger, Jenny Wegert, Anna Wenger, Tim H.H. Coorens, Reem Al-Saadi, Paul Kemps, Jonathan Kennedy, Conor Parks, Nathaniel D. Anderson, Angus Hodder, Aleksandra Letunovska, Hyunchul Jung, Toochi Ogbonnah, Mi Trinh, Henry Lee-Six, Guillaume Morcrette, Marry M. van den Heuvel-Eibrink, Jarno Drost, Ruben van Boxtel, Eline Bertrums, Bianca Goemans, Marjolein Jongmans, Roland Kuiper, Evangelia Antoniou, Dirk Reinhardt, Jack Bartram, Ciaran Hutchinson, Gordan Vujanic, Christian Vokuhl, Tanzina Chowdhury, Rhoikos Furtwängler, Norbert Graf, Kathy Pritchard-Jones, Manfred Gessler, Sam Behjati. Somatic genetic development of Wilms tumor via normal kidneys in predisposed children [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pediatric Cancer Research; 2024 Sep 5-8; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl):Abstract nr PR002.
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Jamaludin, Ahmad. "ANALISIS STRUKTUR TEKS, KOGNISI SOSIAL, DAN DIMENSI SOSIAL DALAM NOVEL PULANG KARYA TERE LIYE (ANALYSIS OF TEXT STRUCTURE, SOCIAL COGNITION, AND SOCIAL DIMENSIONS IN NOVEL PULANG CREATION TERE LIYE)." JURNAL BAHASA, SASTRA DAN PEMBELAJARANNYA 12, no. 1 (March 30, 2022): 49. http://dx.doi.org/10.20527/jbsp.v12i1.13045.
Повний текст джерелаАнотація:
AbstractAnalysis of Text Structure, Social Cognition, and Social Dimensions in Novel PulangCreation Tere Liye. The purpose of this study is to describe the structure of the text, socialcognition, and dimensions used in the novel Pulang by Tere Liye when viewed from theanalysis of Teun A. Van Dijk's critical discourse analysis. This study uses the CriticalDiscourse Analysis approach developed by Teun A. Van Dijk and uses the descriptivequalitative method. The results obtained in the novel Pulang Tere Liye's text structure isdivided into several elements, namely, macrostructure, superstructure, and microstructure.The author's macro structure has the theme of betrayal. There are several stages in thesuperstructure, namely the stages of settlement, conflict arising, increasing conflict, climax,and resolution. Microstructure uses semantics, syntax, stylistic, and rhetoric. Semanticelements are divided into several parts, namely, background, detail and purpose. The settingof this novel are Sumatra, the Jungle Forest of Sumatra, Hong Kong, Tokyo Airport, theCapital Harbor. The details used by the author are more beneficial to him but some aredetrimental to him. The author's intent is stated explicitly and clearly so that the readerunderstands and easily understands the story. In syntax, it is divided into several parts,namely coherence, pronouns, and sentence forms. Coherence used is meaningful coherenceof cause and effect, emphasis, location or time, addition, inference, and conflict. Thepronouns used in this novel are the first singular pronouns aku (I), the first plural pronounkami and kita (we), the second singular pronoun, anda, kau and mu, (you), the second pluralpronoun kalian (all of you), the third singular pronoun ia and dia, and the third pluralpronoun mereka (they, them).The froms of sentences used by the writer are active andpassive sentences. The style of language used is the style of language anaphora, epanalepsis,asonance, simile, pleonasm, correction, aptronym, antithesis, sarcasm, alonym, erotesis, andasidenton. Rhetorical cases are divided into several parts, namely graphics; the author usesemphasis with words or sentences in italics. The metaphors used by the writer are dailyexpressions, proverbs, and proverbs. The expressions used referred to sad and happyexpressions. The social cognition is divided into several elements, namely knowledge,opinions and attitudes, and ideology. Furthermore, the social dimension is divided intoseveral elements, namely power and access.Key words: critical discourse, text structure, social cognition, social dimensions, novelAbstrakAnalisis Struktur Teks, Kognisi Sosial, dan Dimensi Sosial dalam Novel Pulang KaryaTere Liye. Tujuan penelitian mendeskripsikan struktur teks, kognisi sosial, dan dimensiyang digunakan dalam novel Pulang karya Tere Liye bila ditinjau dari analisis wacana kritisTeun A. Van Dijk. Penelitian ini menggunakan pendekatan Analisis Wacana Kritis yangdikembangkan oleh Teun A. Van Dijk dan menggunakan metode deskriptif kualitatif. Hasilpenelitian yang diperoleh dalam novel Pulang karya Tere Liye yaitu struktur teks terbagimenjadi beberapa elemen yaitu struktur makro, superstruktur, dan struktur mikro. Strukturmakro pengarang mengangkat tema penghianatan. Superstruktur terdapat beberapa tahapanyakni tahap penyituasian, tahap pemunculan konflik, tahap peningkatan konflik, tahapklimaks, dan tahap penyelesaian. Struktur mikro menggunakan semantik, sintaksis, stilistik,dan retoris. Elemen semantik terbagi beberapa bagian yaitu latar, detil dan maksud. Lataryang digunakan dalam novel ini yaitu di Sumatera, Hutan Rimba Sumatera, Hongkong,Bandara Tokyo, Pelabuhan Ibu Kota. Detil yang digunakan pengarang lebih menguntungkandirinya namun ada pula yang merugikan dirinya. Maksud disampaikan penulis secaraeksplisit dan jelas sehingga pembaca mengerti dan mudah memahami cerita. Pada sintaksis,terbagi menjadi beberapa bagian yaitu koherensi, kata ganti, dan bentuk kalimat. Koherensiyang digunakan yaitu koherensi bermakna sebab akibat, penekanan, lokasi atau waktu,penambahan, penyimpulan, dan pertentangan. Kata ganti yang digunakan yaitu kata gantipertama tunggal aku, kata ganti pertama jamak kami dan kita, kata ganti kedua tunggal anda,kau, dan mu, kata ganti kedua jamak kalian, kata ganti ketiga tunggal ia dan dia, kata gantiketiga jamak mereka. Bentuk kalimat yang digunakan penulis yaitu kalimat aktif dan pasif.Gaya bahasa yang digunakan yaitu gaya bahasa anafora, epanalepsis, asonansi, simile,pleonasme, koreksio, aptronim, antitesis, sarkasme, alonim, erotesis, dan asidenton. Retoristerbagi menjadi beberapa bagian yaitu grafis, penulis menggunakan penekanan dengan kataatau kalimat yang dicetak miring. Metafora yang digunakan penulis yaitu ungkapan seharihari, peribahasa, dan pepatah. Ekspresi yang digunakan yaitu ekspresi sedih dan bahagia.Pada kognisi sosial terbagi menjadi beberapa elemen yaitu pengetahuan, opini dan sikap,serta ideologi. Selanjutnya, dimensi sosial terbagi menjadi beberapa elemen yaitu kekuasaandan akses.Kata-kata kunci: wacana kritis, struktur teks, kognisi sosial, dimensi sosial, novel
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Estrada, Alejandro, Paul A. Garber, and Abhishek Chaudhary. "Current and future trends in socio-economic, demographic and governance factors affecting global primate conservation." PeerJ 8 (August 21, 2020): e9816. http://dx.doi.org/10.7717/peerj.9816.
Повний текст джерелаАнотація:
Currently, ~65% of extant primate species (ca 512 species) distributed in 91 countries in the Neotropics, mainland Africa, Madagascar, South Asia and Southeast Asia are threatened with extinction and 75% have declining populations as a result of deforestation and habitat loss resulting from increasing global market demands, and land conversion for industrial agriculture, cattle production and natural resource extraction. Other pressures that negatively impact primates are unsustainable bushmeat hunting, the illegal trade of primates as pets and as body parts, expanding road networks in previously isolated areas, zoonotic disease transmission and climate change. Here we examine current and future trends in several socio-economic factors directly or indirectly affecting primates to further our understanding of the interdependent relationship between human well-being, sustainable development, and primate population persistence. We found that between 2001 and 2018 ca 191 Mha of tropical forest (30% canopy cover) were lost as a result of human activities in the five primate range regions. Forty-six percent of this loss was in the Neotropics (Mexico, Central and South America), 30% in Southeast Asia, 21% in mainland Africa, 2% in Madagascar and 1% in South Asia. Countries with the greatest losses (ca 57% of total tree cover loss) were Brazil, Indonesia, DRC, China, and Malaysia. Together these countries harbor almost 50% of all extant primate species. In 2018, the world human population was estimated at ca 8bn people, ca 60% of which were found in primate range countries. Projections to 2050 and to 2100 indicate continued rapid growth of the human populations in these five primate range regions, with Africa surpassing all the other regions and totaling ca 4bn people by the year 2100. Socioeconomic indicators show that, compared to developed nations, most primate range countries are characterized by high levels of poverty and income inequality, low human development, low food security, high levels of corruption and weak governance. Models of Shared Socioeconomic Pathway scenarios (SSPs) projected to 2050 and 2100 showed that whereas practices of increasing inequality (SSP4) or unconstrained growth in economic output and energy use (SSP5) are projected to have dire consequences for human well-being and primate survivorship, practices of sustainability-focused growth and equality (SSP1) are expected to have a positive effect on maintaining biodiversity, protecting environments, and improving the human condition. These results stress that improving the well-being, health, and security of the current and future human populations in primate range countries are of paramount importance if we are to move forward with effective policies to protect the world’s primate species and promote biodiversity conservation.
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Benej, Martin, Katarina Benejova, Rebecca Hoyd, Caroline Wheeler, Daniel Spakowicz, and Nicholas C. Denko. "Abstract 7057: Validation of OXPHOS gene amplification as a driver of treatment resistance in non-small cell lung cancer." Cancer Research 84, no. 6_Supplement (March 22, 2024): 7057. http://dx.doi.org/10.1158/1538-7445.am2024-7057.
Повний текст джерелаАнотація:
Abstract Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. Up to 90% of all lung cancers are non-small cell lung cancer (NSCLC). NSCLC is a complex and highly aggressive disease typical for poor prognosis and high rates of treatment resistance. Clinical management of NSCLC varies according to the stage. High-dose stereotactic body radiation therapy (SBRT) is the standard of care for localized non-resectable NSCLC. However, tumor hypoxia is a significant barrier to effective radiation therapy. In the last decade, first line NSCLC treatment has been substantially reinforced with the introduction of immunotherapy targeting immune checkpoints such as programmed cell death 1 (PD-1), yet long-term disease control occurs in less than 25% of NSCLC patients. Therefore, understanding the mechanisms of treatment resistance is essential to address the dire need of introducing novel synergistic therapies to enhance anti-cancer treatment response in refractory NSCLC tumors. The basis of tumor hypoxia has traditionally been attributed to the oxygen supply deficit as malformed tumor vasculature fails to meet the high demand of the rapidly proliferating tumor mass. However, our preliminary analysis of NSCLC patient datasets in the Cancer Genome Atlas (TCGA) PanCancer dataset revealed a significant correlation between high-level expression of nuclear genes encoding mitochondrial subunits essential for oxidative phosphorylation (OXPHOS), and high-level expression of hypoxia-regulated genes (Buffa hypoxia score). Furthermore, we have observed a direct correlation between copy number amplification (CNA) of several OXPHOS genes and hypoxia levels in patient samples. Because mitochondrial function consumes up to 90% of available cellular oxygen, its activity may be indirectly regulating oxygen availability in the tumor microenvironment by rapidly consuming oxygen upon its delivery to the tumor. Moreover, we have identified that almost 40% of NSCLC patients harbor CNA of these essential OXPHOS genes. To provide mechanistic insight into these clinical observations, we have generated mouse syngeneic NSCLC cell lines with modified mRNA expression levels of OXPHOS genes (representing deletion, diploid and amplified number of copies) identified in our screen and observed a direct effect on the rates of mitochondrial oxygen consumption in these cells. Our study investigates the previously unknown role of OXPHOS gene copy number in driving mitochondrial oxygen demand and thus contributing to tumor hypoxia and treatment resistance in NSCLC. Citation Format: Martin Benej, Katarina Benejova, Rebecca Hoyd, Caroline Wheeler, Daniel Spakowicz, Nicholas C. Denko. Validation of OXPHOS gene amplification as a driver of treatment resistance in non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7057.
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Bardia, Aditya, Patrick Neven, Guillermo Streich, Alberto J. Montero, Frédéric Forget, Marie-Ange Mouret-Reynier, Joo Hyuk Sohn, et al. "Abstract GS2-02: Elacestrant, an oral selective estrogen receptor degrader (SERD), vs investigator’s choice of endocrine monotherapy for ER+/HER2- advanced/metastatic breast cancer (mBC) following progression on prior endocrine and CDK4/6 inhibitor therapy: Results of EMERALD phase 3 trial." Cancer Research 82, no. 4_Supplement (February 15, 2022): GS2–02—GS2–02. http://dx.doi.org/10.1158/1538-7445.sabcs21-gs2-02.
Повний текст джерелаАнотація:
Abstract Background: Endocrine therapy(ET) plus CDK4/6 inhibitor (i) is the mainstay for the management of estrogenreceptor-positive (ER+)/HER2- mBC. However, most patients (pts) with ER+ mBCeventually experience disease progression, including development of ESR1mutations (mESR1). Elacestrant, an oral SERD, demonstrated preclinical activity,and clinical activity in a phase 1 trial in ER+ mBC, including responses in ptswith prior fulvestrant, CDK4/6i, and mESR1tumors (Bardia JCO 2021).. Methods: EMERALD(NCT03778931), a multicenter, international, randomized, open-label, controlledphase 3 trial, enrolled postmenopausal pts with ER+/HER2- mBC who had received 1-2prior lines of ET and ≤1 line of chemotherapy in the mBC setting and had prior progressionon a ET plus CDK4/6i. Pts were randomized 1:1 to elacestrant (400 mg orallydaily) or standard of care (SOC; investigator’s choice of fulvestrant or anaromatase inhibitor). Stratification factors included mESR1 status (by central lab), priorfulvestrant exposure, and presence of visceral disease. The study had 2 primary endpoints of progression-free survival (PFS), by blindedindependent review committee, in pts withtumors harboring mESR1 and in all pts (mESR1 or mESR1 notdetected). Secondary endpoints included: overall survival (OS), safety, tolerability,and quality of life. An alpha-value of 0.0475 was used to determine statisticalsignificance (2-sided using the truncated Hochberg procedure).. Results: EMERALD enrolled 477 pts(228 with mESR1) between Feb 2019 - Oct 2020, with 239 pts randomized toreceive elacestrant vs 238 pts to SOC. Demographics and disease characteristicswere well-balanced across treatment arms [median age: 63 yrs vs 63.5 yrs; 2prior lines: 46% vs 40.8%; prior CDK4/6i: 100% in both arms]. The study met bothprimary endpoints. There was a 30% reduction in the risk of progression ordeath in the elacestrant arm in all pts (HR=0.697 [95% CI: 0.552, 0.88]; P=0.0018),and a 45% (HR=0.546 [95% CI: 0.387, 0.768]; P=0.0005) reduction in therisk of progression or death in pts with mESR1.For both endpoints, results in key prespecified subgroups, including visceral metastases,number of prior lines of therapy, pretreatment with fulvestrant, and geographicalregion, were consistent with the overall outcome. The PFS rate at 12 months was 22.32% (95% CI: 15.24%, 29.40%)with elacestrant vs 9.42% (95% CI: 4.02%, 14.81%) with SOC in all pts, and26.76% (95% CI: 16.17%, 37.36%) vs 8.19% (95% CI: 1.26%, 15.12%) in the mESR1 subgroup. The prespecified interim OS analysis plannedat the time of the final PFS analysis (allocated2-sided alpha level of 0.0001) demonstrated a trend in favor of elacestrant inall pts (HR=0.751 [95% CI: 0.542, 1.038]; P=0.0821) and in pts with mESR1(HR=0.592 [95% CI: 0.361, 0.958]; P=0.0325). The final OS analysisis expected next year. Common (>10%) treatment-related adverse events (AEs) withelacestrant vs SOC included: nausea (25.3% vs 8.7%), vomiting (11% vs 2.6%), and fatigue (11% vs 7.9%), mostlygrade 1/2. Treatment-emergent AEs leading to discontinuation of elacestrant orSOC were infrequent in both arms (6.3% and 4.4%). Grade ≥3 treatment-relatedAEs in the elacestrant arm vs SOC were 7.2% vs 3.1%, mainly driven by nausea(2.1% vs 0.9%). There were no treatment-related deaths in either group.. Conclusions:Elacestrant is the first oral SERD to demonstrate a statistically significantand clinically meaningful improvement of PFS vs SOC in a randomized phase 3study in pts with ER+/HER2- mBC in the 2nd/3rd-linesetting, including those whose tumors harbor mESR1. Elacestrant was well tolerated and hasthe potential to become the new standard of care for pts with ER+/HER2- mBC. Citation Format: Aditya Bardia, Patrick Neven, Guillermo Streich, Alberto J. Montero, Frédéric Forget, Marie-Ange Mouret-Reynier, Joo Hyuk Sohn, Peter Vuylsteke, Kathleen K. Harnden, Hung Khong, Judit Kocsis, Florence Dalenc, Virginia Kaklamani, Patrick Dillon, Sunil Babu, Simon Waters, Ines Deleu, José García-Sáenz, Emilio Bria, Marina Cazzaniga, Janice Lu, Philippe Aftimos, Javier Cortes, Shubin Liu, Dirk Laurent, Maureen G. Conlan, Francois-Clement Bidard. Elacestrant, an oral selective estrogen receptor degrader (SERD), vs investigator’s choice of endocrine monotherapy for ER+/HER2- advanced/metastatic breast cancer (mBC) following progression on prior endocrine and CDK4/6 inhibitor therapy: Results of EMERALD phase 3 trial [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr GS2-02.
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Armstrong, Richard N., Mariana Benicio, Houtan Moshiri, Hongbing Li, Bozana Zlateska, Olga I. Gan, Eric R. Lechman, John E. Dick, and Yigal Dror. "Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage." Blood 136, Supplement 1 (November 5, 2020): 37. http://dx.doi.org/10.1182/blood-2020-143103.
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Diamond-Blackfan anemia (DBA) is a hereditary bone marrow failure disorder that is characterized by erythropoiesis failure and chronic anemia and is frequently associated with physical malformations. Considered a ribosomopathy, most patients harbor pathogenic mutations in one of at least 22 large or small ribosomal protein genes in an autosomal dominant manner, however rarer cases involving mutations in GATA1, TSR2 and EPO have also been described. A recent study of the architecture of the human hematopoietic hierarchy throughout development (Notta et al, Science 2016) showed that, after birth, unipotent progenitors can derive directly from multipotent progenitors without intermediate differentiation into oligopotent progenitors. Critically, this work identified novel progenitors for which the abundance, clonal capacity and progenitor function is currently unknown in many benign and malignant hematological disorders. Specifically, multipotent, common myeloid and megakaryocyte-erythroid progenitors (MPP, CMP and MEP) were found to be functionally heterogeneous and could be subdivided (F1, F2 and F3 subtypes) based on the combination of CD71 and BAH1 expression. We hypothesized that in-depth analysis of these novel and previously reported progenitors will better elucidate hematopoiesis in DBA, providing insights in to DBA pathogenesis and erythropoietic failure. Using flow cytometry, we quantified the frequencies of 11 hematopoietic stem and progenitor cell (HSPC) populations: HSC, MPP F1-F3, CMP F1-F3, MEP F1-F3 and granulocyte-monocyte progenitors (GMP), from the BM specimens of 8 DBA patients harboring ribosomal protein mutations and 6 healthy age-matched control donors. To characterize the function of HSPCs in DBA we then utilized a highly sensitive and quantitative single-cell in-vitro stromal feeder-based differentiation assay that supports the expansion and lineage commitment of single HSCPs towards mature cell types (myeloid, erythroid and megakaryocytes) with progeny immunophenotyping and quantification by flow cytometry. Our refined quantification of HSPCs by flow cytometry showed that the defect of erythropoiesis in DBA patients starts at the CMP/MEP compartment. Namely, CMP-F2 and CMP-F3 as well as MEP-F2 and MEP-F3 sub-populations that are predicted to form erythroid cells were significantly reduced in DBA patients compared to healthy aged-matched individuals (Figure 1A-B). In contrast, CMP/MEP-F1 sub-populations that are predicted to form only myeloid cells (BAH1-/CD71-) showed no significant difference compared to healthy controls. Importantly, the multipotent compartment (HSC and MPP) did not significantly differ from that of healthy controls. Functional analysis of F2/F3 CMP/MEP HSCP sub-populations in single-cell colony assays showed that they have a high propensity to produce erythroid progeny in healthy control samples (Figure 1C). In contrast, in DBA patients these HSCPs had limited erythroid forming potential, but maintain a high propensity to develop myeloid colonies (Figure 1D). To our knowledge this is the first study that the HSCP sub-populations F1/F2/F3 HSCP fractions have been analyzed in DBA. Collectively, these data indicate that the hematopoietic defect in DBA occurs in erythroid-producing CMP/MEP populations. Our data show that these sub-populations are both reduced and dysfunctional in DBA patients and we suggest these abnormalities lead to the pure red cell aplasia seen in these patients. Figure 1: DBA patients have reduced CMP and MEP sub-populations that behave dysfunctional in-vitro. A-B) DBA patients have reduced CMP-F2/3 (A) and MEP-F2/3 (B) sub-populations in their bone marrow. C) CMP F2-F3 and MEP F2-F3 have a high propensity to produce erythroid cell types in healthy controls. D) Single-cells isolated from the CMP-F2/3 and MEP-F2 population of DBA patients produced proportionally fewer erythroid and greater myeloid colonies in in-vitro colony assays (plot shows the mean respective proportions from all healthy controls and DBA patients tested, each N=5). Disclosures Dick: Bristol-Myers Squibb/Celgene: Research Funding.
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Bensmann, Boris, Lena Viviane Buehre, and Richard Hanke-Rauschenbach. "Reference Electrodes in PEM Water Electrolysis – a Review and Experimental Investigation of Oxygen and Hydrogen Evolution Reaction Kinetics." ECS Meeting Abstracts MA2022-01, no. 34 (July 7, 2022): 1372. http://dx.doi.org/10.1149/ma2022-01341372mtgabs.
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Membrane electrode assemblies (MEA) and specifically the anode catalyst are of particular interest in PEM water electrolysis (WE) research as they are considered key components for the capital expenditure and operating expenditure of a PEMWE system (1). An effective method to understand the operation of the MEA is to apply diagnostic tools during the operation of the electrolysis cell. Previous studies in this regard have been mainly limited to the total cell voltage. However, the individual electrode behavior cannot be investigated in the standard setup. To improve the MEA design, the individual electrode behavior is crucial. This can be captured by using a reference electrode (RE). In this work, a salt bridge is used for the first time as RE concept for polarization curves and electrochemical impedance spectroscopy (EIS). The implementation is shown in figure 1.a. Via a porous transport layer impregnated with Nafion, the reference electrode can access the ionic potential of the catalyst layer under investigation. This isolates the kinetic overvoltage from other cell voltage contributions such as ohmic membrane losses, see figure 1.b. The experiments in this study include polarization curves with conventional materials and operating conditions. In addition, EIS is performed to test the applicability of the measurement method in RE operation. Exemplary results are shown in Figure 1.c. In addition, a previous analysis of RE from fuel and electrolytic cells is presented and a classification by electrode type and positioning is made. The key results are subsequently summarized. First, a distinction is made according to the principle behavior of the electrode or its possible configurations. The principal electrode behavior includes the dynamic hydrogen electrode (DHE), the quasireference electrodes, external REs and other configurations. Concrete concepts follow from this. For example, the DHE can be implemented with two platinum wires. By applying a current in the microampere range, the hydrogen evolution reaction takes place in the presence of water. The platinum wire in hydrogen atmosphere becomes the RE (2). Quasireference electrodes are very commonly used with ionic liquids. They are often metal wires (3). A platinum wire is used in a recent work for recording individual electrochemical impedance spectra of anode and cathode (4). Any type of RE can be used as an external RE, such as the silver-silver chloride electrode. Another possibility is to create a free-standing catalyst strip by laser ablation of the MEA. This strip can be used as a reversible electrode to measure the voltage difference with the active catalyst layer participating in the reaction (5). In addition to the behavior of the electrode, a subdivision is made into the position of the RE. In order to separate the potential of one of the two electrodes from the total potential, the measurement can be made as close as possible to the electrode under investigation. This can be implemented by a direct measurement in the catalyst layer (6) or a special geometry of the active area (7). Alternatively, the potential can be measured at the membrane and a correction of the ohmic membrane losses can be used to infer the electrode potential to be investigated. Here, too, two implementations are possible. On the one hand, the RE can be positioned between two membrane halves (4). On the other hand, the membrane can be contacted outside the active area (8). One requirement chosen for the presented concept is the applicability of the RE independent of the geometry of the MEA. Furthermore, the RE should be insensitive to misalignment of the catalyst layers. The exact alignment of the anodic and cathodic catalyst layers is challenging and even small deviations lead to a shift of the potential in the membrane (8). For the two reasons mentioned above, the concept of salt bridge with external RE is used in the direct approach at the electrode. References The national hydrogen strategy (Juni 2020). M. V. Lauritzen, P. He, A. P. Young, S. Knights, V. Colbow and P. Beattie, Journal of New Materials for Electrochemical Systems, 10(3), 143–145 (2007). G. Inzelt, A. Lewenstam, F. Scholz and F. G. K. Baucke, Editors, Handbook of reference electrodes, Springer, Berlin (2013). A. Hartig-Weiß, M. Bernt, A. Siebel and H. A. Gasteiger, J. Electrochem. Soc., 168(11), 114511 (2021). D. Gerteisen, J Appl Electrochem, 37(12), 1447–1454 (2007). E. Brightman, J. Dodwell, N. van Dijk and G. Hinds, Electrochemistry Communications, 52, 1–4 (2015). A. A. Kulikovsky and P. Berg, J. Electrochem. Soc., 162(8), F843-F848 (2015). G. Li and P. G. Pickup, Electrochimica Acta, 49(24), 4119–4126 (2004). Figure 1
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Jaiser, Gerhard. "Angewandte Linguistik [Sammelrezension] Adamczak-Krysztofowicz, Sylwia; Szczepaniak-Kozak, Anna; Rybszleger, Paweł (Hrsg.): Angewandte Linguistik. Neue Herausforderungen und Konzepte: Festschrift für Izabela Prokop zum 70. Geburtstag. Göttingen: V & R Unipress, 2020. – ISBN 978-3-8471-1186-3. 451 Seiten, € 60,00 [Open Access unter https://www.vandenhoeck-ruprecht-verlage.com]. Conrad, Susan; Hartig, Alissa J.; Santelmann, Lynn (Hrsg.): The Cambridge Introduction to Applied Linguistics. New York: Cambridge University Press, 2020. – ISBN 978-1-108-45581-7. 414 Seiten, € 41,20. Bürgel, Christoph; Gévaudan, Paul; Siepmann, Dirk (Hrsg.): Sprachwissenschaft und Fremdsprachendidaktik. Konstruktionen und Konstruktionslernen. Tübingen: Stauffenburg, 2021 (Stauffenburg Linguistik, 119). – ISBN 978-3-95809-161-0. 287 Seiten, € 44,80." Informationen Deutsch als Fremdsprache 50, no. 2-3 (March 15, 2023): 116–20. http://dx.doi.org/10.1515/infodaf-2023-0011.
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GUICHOT REINA, Emilio. "Transparencia y acceso a la información en las entidades locales vascas." Revista Vasca de Administración Pública / Herri-Arduralaritzarako Euskal Aldizkaria, no. 107-II (April 28, 2017): 555–83. http://dx.doi.org/10.47623/ivap-rvap.107.2017.2.14.
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LABURPENA: Lanak informaziora iristeko sarbidearen eta gardentasunaren erregulazioa aztertu du EAEko tokiko entitateetan. Hainbat araudi multzori erreparatu beharra nabarmendu du: estatu mailakoa, Gardentasunari, informazio publikoa eskuratzeko bideari eta gobernu onari buruzko abenduaren 9ko 19/2013 Legeak eta Toki-araubidearen oinarriak arautzen dituen apirilaren 2ko 7/1985 Legeak eratutakoa. EAE mailakoa, Euskadiko Toki Erakundeei buruzko apirilaren 7ko 2/2016 Legeak eratutakoa; horri, aurreikuspenen arabera, EAEko Sektore Publikoaren Gardentasunaren, Herritarren Partaidetzaren eta Gobernu Onaren Legea ere gehituko zaio etorkizunean. Eta toki-mailakoa, EAEko toki-erakunde ugarik onartutako eta onartuko dituzten ordenantzek eratutakoa; estatu mailako eta erkidego mailako multzoak errespetatuz, kasuan kasuko entitaterako antolakuntza-alderdiak zehaztu ahal dituzte, eta oinarrizko estatu mailako araudian eta garapen autonomikokoan aurreikusitako betebehar zabaletatik harago joan daitezke. Azterlanean jokoan dauden zenbait alderdi aztertu dira: gardentasunaren zentzua, Konstituzioan aitortzea eta gardentasuneko estatu-legearen aurretik izan duen lege garapena tokiko eta estatuko legedi orokorrean, estatuko eta erkidego mailako legeak onartzea eta kasuan kasuko aplikazio eremua, baita toki-erakundeen erabakitze esparrua ere, Euskadiko Toki Erakundeei buruzko Legea eta Gardentasuneko EAEko legearen proiektuarekin egokitzea, derrigortasunak, mugak, publizitate aktiboa, publizitate pasiboa edo informazio publikora sarbidea izateko eskubidea, bermeak, eta, azkenik, gardentasun-Legeen eta zinegotziek udal-informaziora iristeko daukaten sarbidearen arteko harremana. RESUMEN: El trabajo analiza la regulación de la transparencia y el acceso a la información en las entidades locales vascas. Pone de relieve la necesidad de atender a varios bloques normativos: el estatal, constituido por la Ley 19/2013, de 9 de diciembre, de transparencia, acceso a la información pública y buen gobierno, por una parte, y a la Ley 7/1985, de 2 de abril, reguladora de las Bases del Régimen Local, por otra. El autonómico vasco, integrado por la Ley 2/2016, de 7 de abril, de Instituciones Locales de Euskadi (LILE) y a la que previsiblemente se unirá la futura Ley de Transparencia, participación ciudadana y buen gobierno del sector público vasco. Y el local, constituido por las Ordenanzas que han ido e irán aprobando no pocas entidades locales vascas, que, respetando los bloques normativos estatal y autonómicos pueden concretar para su respectiva entidad aspectos organizativos e ir más allá de las amplias obligaciones ya previstas en la normativa básica estatal y de desarrollo autonómico. En el estudio se analizan los diversos aspectos en juego: el sentido de la transparencia, su reconocimiento en la Constitución y su desarrollo legal anterior a la Ley estatal de transparencia en la legislación estatal general y local, la aprobación de las leyes estatal y autonómicas y su u respectivo ámbito de aplicación, así como el ámbito de decisión de las entidades locales, la nueva regulación en la LILE y las dudas de encaje con el Proyecto de Ley vasca de transparencia, los obligados, los límites, la pu blicidad activa, el derecho de acceso a la información pública o publicidad pasiva,las garantías y, finalmente, la relación de las Leyes de transparencia con elacceso por los concejales a la información municipal. ABSTRACT: This work analyzes the regulation of transparency and the access to information within the Basque local governments. It highlights the need to pay attention to several legal systems: that of the State, with Act 19/2013 of December 9th, on transparency, access to public information and good governance on one hand and that of the Act 7/1985 of April 2nd, governing the bases of the local regime on the other. The Basque autonomous system with Act 2/2016 of April 7th on Local Entities of Euskadi (LILE) and which predictably will also be integrated with the future Act on transparency, citizen participation and good governance within the Basque public sector. And the local, with the ordinances approved and yet to be enacted by not few Basque local entities which if they do not interfere in State and Autonomous systems can specify for its own entity organizational issues and go beyond the broad obligations established by the State basic regulation and that of autonomous development. In this study the different aspects at stake are studied: the meaning of transparency, the acknowledgement by the Constitution and its legal development previous to the State Act on Transparency by the State general and local legislation, the approval of the State and Autonomous acts and their respective scope of application, together with the decision-making scope of local entities, the new regulation by the LILE and the doubts of fitting with the Basque bill on transparency, the persons concerned, the limits, the active advertisement, the right of access to public information or passive advertising, the guarantees and finally the relationship between the Acts of transparency with the access of councilmen and councilwomen to the municipal information.
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Harvey, Adela, Markes E. Johnson, and Robert Harvey. "Heterozoan carbonate-enriched beach sand and coastal dunes—with particular reference to rhodoliths, Dirk Hartog Island, Shark Bay, Western Australia." Facies 64, no. 3 (June 21, 2018). http://dx.doi.org/10.1007/s10347-018-0533-4.
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