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Дисертації з теми "Diseases therapy"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Habich, Hans. "Immunoglobulin therapy in ophthalmic diseases /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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2

Sundaram, V. "Gene therapy for inherited retinal diseases." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1418145/.

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Анотація:

Inherited retinal diseases include a number of disorders which typically affect photoreceptor/retinal pigment epithelial function, and can lead to severe visual impairment. Advances in molecular genetics have allowed the identification of many of the genes responsible for particular conditions, and progress in viral gene transfer technology has enabled the replacement of specific genes into the retina. The first human clinical trial of gene therapy for inherited retinal disease was carried out at Moorfields Eye Hospital and UCL Institute of Ophthalmology, involving 12 patients with RPE65 defic

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3

Amoo, A., and Igor Antonovuch Plesh. "Anthroposophic art therapy in chronic diseases." Thesis, МАТЕРІАЛИ міжнародної науково-практичної інтернет-конференції CHERNIVTSI INTERNATIONAL MEDICAL CONFERENCE (СІМЕС). - м. Чернівці 02-03 червня 2017 р, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12882.

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4

BOTTANI, EMANUELA. "Mitochondrial diseases: from gene function to therapy." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/94380.

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Le malattie mitocondriali sono disturbi genetici caratterizzati da difetti di fosforilazione ossidativa causati da mutazioni nel DNA mitocondriale, o in geni nucleari i cui prodotti sono legati alla fosforilazione ossidativa o alla biologia mitocondriale. La prima parte del progetto è stata focalizzata sulla generazione e la caratterizzazione di un modello murino di malattia mitocondriale, Ttc19ko. I pazienti con mutazioni in TTC19 sviluppano danni neurologici e deficit di complesso III. Ttc19 è una proteina mitocondriale che sembra essere coinvolta nell’assemblaggio e/o stabilità del compless

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5

Martinico, Sandra Carmela Maria. "Assessment of gene therapy for FAP-related diseases." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437300.

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6

Mazlan-Kepli, Wardati. "Antiplatelet therapy and clinical outcomes in cardiovascular diseases." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7831/.

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Анотація:

Cardiovascular diseases (CVD) is a leading cause of death in the world. Despite effective treatment regimens for ischaemic heart disease (IHD) and ischaemic stroke, mortality and recurrence rates remain high. Antiplatelet therapy is on effective treatment and reduces the risk of recurrent heart attack and stroke. Nevertheless, there are patients who stopped or interrupted their antiplatelet therapy for certain reasons or some patients may be resistant or poor responders to antiplatelet therapy. Furthermore, there is evidence of rebound effect in platelet activity after antiplatelet cessation a

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7

Nikolaev, A. L., A. V. Gopin, V. E. Bozhevolnov, S. E. Mazina, E. M. Treschalina, and N. V. Dezhkunov. "Ultrasonic Nanomedicine in the Therapy of Oncological Diseases." Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35412.

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In this paper the authors develop the concept of using solid-phase nanoscale inclusions in biological structures, as the concentrators of acoustic energy for ultrasound therapy of oncological diseases. Particu-lar attention is paid to possibility of synthesis of these inclusions directly in the tumor tissue. The validity of the hypothesis of solid-phase sonosensitization has been confirmed in vitro on bacterial cultures. Super-additive effect of combined action of ultrasound and solid-phase sonosensitizer on bacterial cultures was shown. Experimental studies on animals showed that the ultrasou

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8

CIVILETTO, GABRIELE. "Opa1 overexpression as potential therapy in mitochondrial diseases." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/55460.

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Mitochondrial disorders are a group of highly invalidating human conditions due to defective oxidative phosphorylation, for which no effective treatment is nowadays available. In order to develop effective therapies for these disorders, I focused on an experimental approach based on the manipulation of mitochondrial morphology. Opa1 is a GTPase of the inner mitochondrial membrane involved in both mitochondrial fusion and cristae shaping. The role of OPA1 in mitodynamics has also a documented impact on controlling the assembly of the respiratory supercomplexes and respiratory proficiency. Base

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9

COX, ALYSIA SARAH-MARIE. "Nanoparticles for Therapy and Diagnosis of Neurodegenerative Diseases." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241331.

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Nanoparticles (NPs) are studied as a promising tool to efficiently deliver drugs across biological barriers, which can hinder effective pharmacological treatment for a variety of diseases. One of the key issues to evaluate is the corona, a layer of proteins attached to the surface, formed upon contact of NPs with biological fluids. It is well known that the corona affects bioavailability, toxicity and clearance of NPs. Though the corona is relatively well defined under various conditions, its evolution when it crosses biological barriers was unknown. In my research I utilized gold NPs and a tr

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10

Ross, Colin J. D. "Immuno-isolation gene therapy for lysosomal storage disease /." *McMaster only, 2001.

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11

Peterson, Aida N. "Antibacterial antibodies in the sera of patients needing endodontic therapy." Google Book Search Library Project, 1988. http://books.google.com/books?id=THg9AAAAMAAJ.

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12

Minas, Konstantinos. "New approaches to autoimmune therapy through gene analysis." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted no access until May 19, 2011. Online version available for University member only until May 19, 2012, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25620.

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13

Baek, Rena C. "Therapeutic strategies for the ganglioside storage diseases." Thesis, Boston College, 2008. http://hdl.handle.net/2345/18.

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Анотація:

The Gangliosidoses, to include GM1 gangliosidosis and Sandhoff disease are a class of incurable lysosomal storage disorders characterized by an abnormal accumulation of gangliosides leading to progressive neurodegeneration and eventually death. GM1 gangliosidosis is caused by a genetic defect in the lysosomal-specific acid β-galactosidase, which results in the massive accumulation of ganglioside GM1 primarily in the central nervous system (CNS). Sandhoff disease (SD) results from a defect in the β-subunit of β- Hexosaminidase A and leads to the accumulation of ganglioside GM2 and its asialo de

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14

Niessen, Stijn Johannes Maria. "Towards muscle-targeted-gene-therapy for human and canine diabetes mellitus." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559063.

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15

Charo, Jehad. "Immune and gene therapies for cancer and infectious diseases /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3703-6/.

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16

Millson, Charles Edward. "Photodynamic therapy for the treatment of helicobacter pylori infection." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281686.

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17

Mak, Yiu-fai. "Microbial flora of root canals at the time of obturation and the outcome of treatment." Click to view the E-thesis via HKUTO, 2000. http://sunzi.lib.hku.hk/HKUTO/record/B38628053.

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18

Маркевич, Валентина Володимирівна, Валентина Владимировна Маркевич, Valentyna Volodymyrivna Markevych, and K. L. Illiashenko. "Usage of cytokines in therapy of oncological diseases in oncoginecology." Thesis, Видавництво СумДУ, 2009. http://essuir.sumdu.edu.ua/handle/123456789/4676.

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19

Rigal, Nathalie [Verfasser]. "Improving enzyme replacement therapy for lysosomal storage diseases / Nathalie Rigal." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/115576093X/34.

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20

Choudhury, Sourav Roy. "Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/809.

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Анотація:

Neurological disorders – disorders of the brain, spine and associated nerves – are a leading contributor to global disease burden with a sizable economic cost. Adeno-associated viral (AAV) vectors have emerged as an effective platform for CNS gene therapy and have shown early promise in clinical trials. These trials involve direct infusion into brain parenchyma, an approach that may be suboptimal for treatment of neurodegenerative disorders, which often involve more than a single structure in the CNS. However, overall neuronal transduction efficiency of vectors derived from naturally occurring

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21

Choudhury, Sourav Roy. "Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/809.

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Анотація:

Neurological disorders – disorders of the brain, spine and associated nerves – are a leading contributor to global disease burden with a sizable economic cost. Adeno-associated viral (AAV) vectors have emerged as an effective platform for CNS gene therapy and have shown early promise in clinical trials. These trials involve direct infusion into brain parenchyma, an approach that may be suboptimal for treatment of neurodegenerative disorders, which often involve more than a single structure in the CNS. However, overall neuronal transduction efficiency of vectors derived from naturally occurring

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22

Arn, Ingemar. "A bio-psychological analysis of functional gastrointestinal disorders and a clinical trial of its treatment using psychodrama /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3905-5/.

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23

SCHWINGEL, AGNES R. "Terapia fotodinâmica antimicrobiana no tratamento da candidose em pacientes portadores do virus HIV." reponame:Repositório Institucional do IPEN, 2007. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11645.

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Made available in DSpace on 2014-10-09T12:54:15Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:07:43Z (GMT). No. of bitstreams: 1 12711.pdf: 2036091 bytes, checksum: a4517356221ed0ff2c40f070f9f8233a (MD5)<br>Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia)<br>IPEN/D-MPLO<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo, Sao Paulo

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24

Arteaga, H. Jose. "Strategies of gene and immune therapy for tumors and viral diseases /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-528-x.

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25

Al-Johani, K. "Outcomes of therapy of immunologically-mediated diseases of the oral mucosa." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/751812/.

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Immune-mediated diseases (IMDs) can give rise to long standing painful oral mucosal disease which adversely affect oral function and perhaps lessens quality of life. The present series of studies, retrospectively determine the clinical presentation and long-term efficacy and safety of treatment of large groups of patients with oral lichen planus, mucous membrane pemphigoid, pemphigus vulgaris and orofacial granulomatosis. These diseases are some of the challenging disorders to be managed by oral medicine specialists. It was found that patients with oral lichen planus (OLP) rarely have extra-or

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26

BASSANINI, GIULIA. "EFFECT OF DIET THERAPY ON GUT MICROBIOME IN RARE GENETIC DISEASES." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/828416.

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In the last decades, several studies have explored the human microbiota in different body niches, notably in the gastrointestinal tract. The gut microbiota has been recognized as an additional organ that co-evolves with humans and interacts with host physiology. The gut microbiota plays a key role in the host metabolism and the extraction of energy from food. Diet is the strongest factor shaping the gut microbiota: differences in macronutrient intake may select the growth of specific microbial taxa. Indeed, the diet provides different substrates such as undigested carbohydrates for ferment

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27

Remera, Jeanne Manywa. "Perceptions among caregivers and physiotherapists on the importance of chest physiotherapy in asthmatic children attending hospitals in Kigali, Rwanda." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&amp.

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Childhood asthma is one of the commonest chronic respiratory conditions in developed communities. Chest physiotherapy has traditionally been one of the interventions used mainly after an attack and for a relatively short-period on an outpatient basis. The purpose of the study was to determine the perceptions of physiotherapists and caregivers about the importance of chest physiotheraphy in asthmatic children in Kigali. To achieve this aim the author attempted to identify the perceived benefits of chest physiotherapy for asthmatic children among caregivers<br>to determine the perception of phys

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28

Flood, Lars. "Glucocorticosteroid therapy and steroid resistance in inflammatory bowel disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-020-6/.

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29

Hidaka, Takuya. "Development of Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263495.

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30

Sorarù, Antonio. "Molecular and nanodimensional metal based systems for the therapy against neurodegenerative diseases." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424628.

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Reactive oxygen species (ROS) are harmful species produced during metabolic processes, such as photosynthesis and respiration, of living organism. In both case, the substrate (oxygen/water) undergoes several multi electronic reaction, during which some electrons can “escape” from the catalytic cycle and produce ROS, such as superoxide radical anion, hydrogen peroxide, hydroxyl radical and other derivatives. These species are really dangerous, since they are able to oxidize almost all cellular components. Indeed they can damage lipids, proteins, DNA, affecting cellular functions till cell deat

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31

Baril, Jacinthe. "Interaction between circulatory and respiratory exercise adaptation in chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF)." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97901.

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Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) patients show a marked reduction in exercise capacity compared to that of healthy age-matched individuals. While inadequate gas exchange and resulting hypoxemia appears as the primary factor in COPD, an impaired cardiac output is the predominant explanation for the reduced oxygen delivery in CHF. However, the extent of the contributions of other systemic factors remains unclear. In light of the potential interactions between cardiac output (Qc) and pulmonary hyperinflation, there is surprisingly little data thus far o

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32

巫志偉 and Chi-wai Mo. "Prevention and therapy of infectious bursal disease by molecular approaches." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B30253329.

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33

Brouqueyre, Laurent. "Hydro-acoustic therapy : design, construction and testing." Thesis, Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/18215.

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34

Campos, Ana Margarida Ferreira. "Lipidomic analysis of mesenchymal cells candidates for cell therapy." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15275.

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Mestrado em Bioquímica - Métodos Biomoleculares<br>Mesenchymal stromal cells are adult stem cells found mostly in the bone marrow. They have immunosuppressive properties and they have been successfully applied as biological therapy in several clinical trials regarding autoimmune diseases. Despite the great number of clinical trials, MSCs’ action is not fully understand and there are no identified markers that correlate themselves with the immunomodulatory power. A lipidomic approach can solve some of these problems once lipids are one of the major cells’ components. Therefore, in this study

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35

Yager, Nicole Leanne. "Natural and therapy-induced immune control of HIV-1." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e07f3022-4e14-4844-90ac-8d6f52a40a5a.

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The human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) response is important in the control of HIV-1 infection. Due to the virus having a high rate of mutation, immune pressure can select for variants that are no longer recognised by CTLs to dominate the viral quasispecies. This is similar to how antiretroviral resistance emerges. HIV-1 is therefore adapting to both human leukocyte antigen (HLA)-restricted immune responses and antiretroviral therapy. This thesis initially focused on the natural CTL response to an HLA-B*51-restricted epitope in integrase. This HLA class I

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36

DiPeri, Timothy P. "Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/honors/208.

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Cardiovascular disease (CVD) is the leading cause of death in the United States. Nearly half of the people diagnosed with heart failure (HF) die within 5 years of diagnosis. Brain abnormalities secondary to CVD have been observed in many discrete regions, including the hippocampus. Nearly 25% of patients with CVD also have major depressive disorder (MDD), and hippocampal dysfunction is a characteristic of both diseases. In this study, the hippocampus and an area of the hippocampal formation, the dentate gyrus (DG), were studied in a canine model of HF. Using this canine HF model previously, we

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37

Eleftheriadou, Ioanna. "Development of novel targeted lentiviral vectors for gene therapy of motor neuron diseases." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/27243.

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Анотація:

Motor Neuron Diseases (MND) including Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA) are neurodegenerative diseases that can cause progressive paralysis and premature death, while there are no treatments available up to date. Gene therapy using lentiviruses has been successful at alleviating symptoms and extending survival in murine models of both. Restricting transduction to specific cells, is critical for safe and efficient gene therapy. The aim of this study was to generate novel lentiviral vectors with tropism to motor neurons (MNs) using surface engineering, that in

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38

Ditadi, Andrea. "Cell therapy approach for hematopoietic diseases using fetal cells issued from amniotic fluid." Paris 5, 2008. http://www.theses.fr/2008PA05T036.

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Dans la présente étude, nous avons étudié la possibilité de différencier les cellules souches du liquide amniotique humain (hAFSC) et murin (mAFSC) vers la voie hématopoïétique à la fois in vitro et in vivo. Nous avons de manière reproductible réalisé une différenciation érythroïde par culture des hAFSCs en corps embryoïdes (EB). Plus de 70% des cellules constituant les EB coexprimaient des marqueurs erythroïdes. De plus, 3 mois après l'injection de hAFSC à des souris NOD/SCID irradiées, nous avons pu détecter dans la rate et la moelle osseuse des receveurs des érythrocytes humains. Nous avons

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39

Tavari, Mohsen. "Hybrid molecules as inhibitors of the monoamine oxidases and caspase 3 for neurodegenerative disorders." University of the Western Cape, 2016. http://hdl.handle.net/11394/5069.

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Magister Pharmaceuticae - MPharm<br>Neurodegenerative diseases are multifactorial in nature, and taking the complex nature of these disorders into consideration, multi-target directed ligands may present as better options to treat these disorders than the classic ‘one molecule, one target’ approach. Neurotransmitter amines are catabolized by monoamine oxidase A and B (MAO-A and MAO-B), therefore they have been targeted for the treatment of neuropsychiatric and neurodegenerative diseases. Besides offering a potential antidepressant action in PD, MAO-A inhibitors may also provide a symptomatic

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40

Kammerlind, Ann-Sofi. "Vestibular rehabilitation therapy in dizziness and disequilibrium /." Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med914s.pdf.

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41

Aryamvally, Anjali. "Mitochondrial Replacement Therapy: Genetic Counselors’ Experiences, Knowledge and Opinions." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1583998248123854.

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42

Gliddon, Briony Lee. "Enzyme replacement therapy in a murine model of mucopolysaccharidosis type IIIA /." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phg5595.pdf.

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43

Crawley, Allison Catherine. "Enzyme replacement therapy in a feline model of mucopolysaccharidosis type VI /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phc9107.pdf.

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44

Mulroue, Amy. "Exploring how narrative therapy may facilitate psychosocial adjustment following stroke." Thesis, Canterbury Christ Church University, 2013. http://create.canterbury.ac.uk/12269/.

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Анотація:

Section A is a review of the literature on psychological adjustment following stroke. Empirical research is critically reviewed with reference to two research questions: (1) What do we understand about adjustment following survival of stroke? (2) What psychosocial interventions have been used to support adjustment post-stroke and what are the outcomes? Theoretical models for adjustment to stroke are drawn upon to illuminate the findings. Gaps within the literature are discussed and future directions for research are suggested. Section B describes a study using mixed methods. The purpose of the

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45

Furlan, Roberto. "Development of herpesvirus-based vectors for the treatment of central nervous system autoimmune diseases." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342890.

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46

Jung, Cindy. "Quantitative analysis of lentivirus incorporation of heterologous viral and non-viral proteins for lung gene therapy." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/26648.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Joseph M. Le Doux; Committee Member: AndrÃ©s J. Garcia; Committee Member: Cheng Zhu; Committee Member: Nael McCarty; Committee Member: Richard Compans. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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47

Heller, Raoul. "Engineering of human artificial mini-chromosomes." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360317.

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Yogalingam, Gouri. "Molecular characterisation of feline MPS VI and evaluation of gene therapy /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phy54.pdf.

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Mapiye, Darlington Shingirirai. "Computational genomics approaches for kidney diseases in Africa." University of the Western Cape, 2015. http://hdl.handle.net/11394/4958.

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Philosophiae Doctor - PhD<br>End stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility. Black Africans have been shown to bear an unequal burden of this disease compared to white Europeans, Americans and Caucasians. Despite this, most of the genetic and epidemiological advances made in understanding the aetiology of kidney diseases have been done in other populations outside of sub-Saharan Africa (SSA). Very little research has been un

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Schoultz, Mariyana. "The use of mindfulness-based cognitive therapy for patients with inflammatory bowel disease." Thesis, University of Stirling, 2016. http://hdl.handle.net/1893/23931.

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Background: Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal diseases with a relapsing nature. The two main types are Crohn’s disease (CD) and ulcerative colitis (UC). Both CD and UC patients experience very similar and distressing symptoms: acute abdominal pain, vomiting, malnutrition, fever, fatigue, diarrhoea and rectal bleeding. These symptoms are disabling and have a severe impact on physical and psychosocial wellbeing. Around 30% of patients suffer from moderate to severe psychological distress and have difficulties coping with the illness even in remission. Howeve

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