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Дисертації з теми "Dopamine type I receptor"

Автор: Grafiati

Опубліковано: 19 жовтня 2024

Оновлено: 31 липня 2025

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1

Hatcher-Solis, Candice N. "PHARMACOLOGICAL IMPLICATIONS OF ADENOSINE 2A RECEPTOR- DOPAMINE TYPE 2 RECEPTOR HETEROMERIZATION." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4458.

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G protein-coupled receptors (GPCRs) are heptahelical, transmembrane proteins that mediate a plethora of physiological functions by binding ligands and releasing G proteins that interact with downstream effectors. GPCRs signal as monomers, complexes of the same receptor subtype (homomers), or complexes of different receptor subtypes (heteromers). Recently, heteromeric GPCR complexes have become attractive targets for drug development since they exhibit distinct signaling and cell-specific localization from their homomeric counterparts. Yet, the effect of heteromerization on the pharmacology of

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2

ZANINOVICH, OREL ANTHONY. "THE CLONING OF AN INDR-TYPE DOPAMINE RECEPTOR IN MANDUCA SEXTA." Thesis, The University of Arizona, 2008. http://hdl.handle.net/10150/192256.

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3

Mann, Miranda Jane. "A neuropsychological investigation of dopamine receptor 4 differences among attention deficit hyperactivity disorder-combined type and control children /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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4

Gorji, Hassan. "Role of adenylyl cyclase type 5 in the regulation of the dopamine D3 receptor phosphorylation." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27364.

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Adenylyl cyclase type 5 (AC5) is expressed in the brain where the highest density of the dopamine D3 receptor (D3R) has been found. The D3R-mediated Gi/o protein activation leads to a specific inhibition of AC5. Therefore, as AC5 is the main signalosome partner of D3R, I hypothesize that D3R phosphorylation is differentially regulated in cells expressing AC5. In HEK293 cells expressing D3R alone, D3R undergo dopamine-induced phosphorylation. Interestingly, in cells co-expressing AC5 and D3R, D3R undergoes a Galphai-dependent dephosphorylation upon dopamine exposure while retaining its ability

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5

Maier, Annette Louise. "Comparative regional ontogeny of dopamine D₁ receptor binding and mRNA expression in pre- and postnatal rat brain /." Zürich, 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10902.

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6

Etchepare, Laetitia. "Role of glutamate N-Methyl-D-Aspartate receptor surface trafficking in the firing pattern of midbrain dopaminergic neurons." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0849/document.

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Les neurones dopaminergiques (DA) mésencéphaliques jouent un rôle prépondérant dans de nombreuses fonctions cérébrales telles que la motivation, mais ils sont également impliques dans l’émergence de pathologies telles que la maladie de Parkinson et l’addiction aux drogues. Ces processus ayant en commun de modifier l’activité de décharge des neurones DA mésencéphaliques, il est d’une importance primordiale de comprendre les mécanismes sous-tendant cette activité. Parmi les différents canaux ioniques et récepteurs impliques dans la génération de l’activité de décharge des neurones DA, les récept

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7

Roberts-Crowley, Mandy L. "Modulation of Ca_v1.3 L-Type Calcium Channels by Arachidonic Acid and Muscarinic M₁ Receptors: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/348.

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Membrane excitability, gene expression, and neurotransmitter release are all controlled by voltage-gated L-type Ca2+ (L- )channels. In turn, Ca2+ channels are highly regulated by signal transduction cascades initiated by G protein-coupled receptor (GPCR) activation. In medium spiny neurons of the striatum, both the muscarinic M1 receptors (M1R) and dopaminergic D2 receptors (D2R) specifically inhibit the Cav1.3 L-channel. In Chapters III and IV, the pathways downstream of M1Rs and D2Rs are examined to determine whether an overlap or intersection in inhibition of Cav1.3 occurs by these two rece

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8

Lucas, Guillaume. "Etude in vivo des modalités d'intervention de la sérotonine et des récepteurs sérotoninergiques de type 5-HT/2A/2C, 5-HT3 et 5-HT4 dans le contrôle de la transmission dopaminergique nigro-striée et mésoaccumbale chez le rat." Bordeaux 2, 1999. http://www.theses.fr/1999BOR28692.

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9

Hegron, Alan. "Implication des récepteurs de la mélatonine dans les troubles neurologiques et le diabète de type 2 et identification de régions clés du récepteur MT1 responsables de sa sélectivité fonctionnelle." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS555/document.

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La mélatonine est une neurohormone produite principalement par la glande pinéale de manière circadienne et agissant par l’activation de deux récepteurs couplés aux protéines G (RCPGs) appelés MT1 et MT2. La mélatonine régule de nombreuses fonctions physiologiques importantes. La régulation des niveaux de dopamine (DA) et de glucose en font partie mais nous ne savons pas clairement comment la mélatonine les régule.Les niveaux de DA extracellulaire sont principalement régulés par son transporteur (DAT) responsable de sa recapture dans les neurones présynaptiques afin de prévenir d’une hyperactiv

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10

Thirtamara, Rajamani Keerthi Krishnan. "Animal Models of Drug Addiction and Autism Spectrum Disorders." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1386011455.

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11

Domingo, Rodriguez Laura 1992. "Neurobiological mechanisms involved in the loss of control over food intake." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668410.

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The easy access to palatable foods is a major contributing factor for compulsive eating and development of food addiction, a disorder closely linked to obesity and binge eating disorder. The concept of food addiction is still controversial but a validated tool for diagnosis, the Yale food addiction scale (YFAS 2.0), is widely accepted. However, the complex multifactorial nature of this disorder and the unknown neurobiological mechanistic correlation explain the current lack of effective treatments. In this thesis, we used a food addiction mouse model to elucidate the crucial role of the glutam

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12

Benac, Nathan. "Molecular mechanisms underlying the surface organization of the NMDA receptors during development." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0185.

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Comprendre comment les neurones se développent pour former le schéma organisé des connexions synaptiques reste une question centrale en neurosciences. La grande majorité des synapses excitatrices se forment tôt au cours du développement pendant une fenêtre de synaptogenèse. Les récepteurs N-méthyl-D-aspartate (NMDAR) sont depuis longtemps considérés comme un candidat important pour stimuler la synaptogenèse, car les données in vivo et in vitro montrent un rôle clé des NMDARs pendant cette phase. De plus, le fait que les NMDARs se trouvent dans les synapses « silencieuses », immatures sur le pl

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13

Sugamori, Kim S. "The dopamine D1C receptor, expansion and origin of the dopamine D1 receptor family." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0001/NQ41320.pdf.

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14

Torvinen, Maria. "Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-298-1/.

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15

Middleton, Lisa Sue. "Nicotine receptor modulation of dopamine transporters." Lexington, Ky. : [University of Kentucky Libraries], 2005. http://lib.uky.edu/ETD/ukyphsc2006d00383/Middleton.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2005.<br>Title from document title page (viewed on March 2, 2006). Document formatted into pages; contains vii, 264 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 196-260).

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16

Middleton, Lisa Sue. "NICOTINIC RECEPTOR MODULATION OF DOPAMINE TRANSPORTERS." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/412.

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The current project examined the ability of nicotine to modulate dopamine transporter (DAT) function. Initial experiments determined the dose-response for nicotine to modulate dopamine (DA) clearance in rat striatum and medial prefrontal cortex (MPFC) using in vivo voltammetry and determined if this effect was mediated by nicotinic receptors (nAChRs). In both striatum and MPFC, nicotine increased DA clearance in a mecamylamine-sensitive manner, indicating nAChR-mediation. The effect of acute nornicotine on DAT function was also determined. In contrast to nicotine, nornicotine in a dose-related

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17

Genn, Rachel F. "Dopamine receptor subtypes and ingestive behaviour." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4303/.

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Both centrally and systemically administered dopamine agonists and antagonists decrease ingestive behaviour. The aim of this thesis was to examine whether drugs acting at different receptor subtypes decreased intake in different ways. A microstructural analysis was used to examine dopaminergic drug effects on licking behaviour. A dopamine D3 receptor agonist, 7-OH-DPAT, a dopamine D2 receptor antagonist raclopride and a mixed dopamine D2/D3 agonist quinpirole were compared in this paradigm. These drugs reduced the number of licks by differentially decreasing parameters which are thought to ref

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18

Rimondini-Giorgini, Roberto. "Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3617-X/.

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19

Kim, Douglas S. "Dopamine and adenosine receptor function in adult and developing dopamine-deficient mice /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/5063.

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20

Knapp, Mark. "Development of dopamine receptor-expressing adenoviral vectors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ28801.pdf.

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21

D'Souza, Ursula M. "Structure of the Dâ†2 dopamine receptor." Thesis, University of Kent, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259680.

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22

Salmi, Peter. "Clozapine as a dopamine D1 receptor agonist /." Stockolm : Universitet Stockholms, 1998. http://catalogue.bnf.fr/ark:/12148/cb401175060.

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23

Satchell, Rupert. "Signalling and regulation of the D1 dopamine receptor." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/38068.

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Signalling, desensitization and allosteric modulation have been investigated in cell-lines endogenously or recombinantly expressing human D1 dopamine receptors. Each of the D1 dopamine receptor agonists studied (dopamine, SKF 38393, SKF 81297, SKF 82958, SKF 83822, SKF 83959, dihydrexidine and rotigotine) concentration-dependently increased cAMP accumulation in SK-N-MC human neuroblastoma cells endogenously expressing the D1 dopamine receptor. However, D1 receptor stimulation failed to evoke a Ca2+ response. Agonist pre-treatment of SK-N-MC cells induced acute desensitization, characterized by

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24

Oldenhof, John. "SH3 binding domains in the dopamine D4 receptor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0017/NQ45764.pdf.

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25

謝志恒 and Chi-hang Tse. "Molecular cloning of the goldfish dopamine D2 receptor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B42128511.

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26

Tse, Chi-hang. "Molecular cloning of the goldfish dopamine D2 receptor." Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B42128511.

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27

Karper, Patrick Eugene. "Role of the Dopamine D₁-like receptor in amphetamine-induced behavioral sensitization: A study using Dopamine D₁A-receptor deficient mice." CSUSB ScholarWorks, 2000. https://scholarworks.lib.csusb.edu/etd-project/1682.

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The ability of the indirect dopamine agonist, amphetamine, to produce behavioral sensitization was assessed in adult D₁A-deficient and wild-type mice. It was originally predicted that : 1) dopamine (DA) D₁-like receptors are necessary for the occurrence of short- and long-term amphetamine-induced behavioral sensitization, 2) DA D₁-like receptors are necessary for environmental conditioning factors associated with amphetamine-induced behavioral sensitiazation, and 3) DA D₅ receptors are required for amphetamine-induced behavioral sensitization. Locomotor activity and sterotyped sniffing were as

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28

Sheppard, Ashley Brianna. "Sex Differences in Nicotine-Conditioned Hyperactivity in a Model of Dopamine D2 Receptor Priming: Roles of Dopamine D2 and D3 Receptor Subtypes." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1978.

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The aim of this investigation was to determine the effect of a nicotine-conditioned context on locomotor hyperactivity in an animal model of D2-priming, and whether conditioned hyperactivity could be blocked by the D2 antagonist eticlopride or the D3 antagonist nafadotride. D2-primed male rats showed enhanced nicotine sensitization as evidenced by statistically significant differences in horizontal activity. D2-primed female rats administered nicotine demonstrated an increased hypoactive response after initial sensitization and increased stereotypy. Eticlopride and nafadotride blocked sensitiz

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29

Kotowski, Sarah. "Regulation of dopamine signaling by D1 receptor membrane trafficking." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390053.

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30

Ray, Avi Andrew. "SH3 binding domains in the dopamine D¦3 receptor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0018/MQ45843.pdf.

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31

Zawarynski, Paul. "Dopamine D2 receptor monomers, dimers and higher order oligomers." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0025/MQ40852.pdf.

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32

Terasmaa, Anton. "Dopamine D2 receptor G protein coupling and its regulation /." Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-788-6/.

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33

Pesek, Erin Fae Newland M. Christopher. "The role of dopamine receptor subtypes in reinforced variability." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SUMMER/Psychology/Thesis/Pesek_Erin_41.pdf.

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34

Shaikh, Sanober. "Molecular genetic studies of dopamine receptor genes in schizophrenia." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243332.

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35

Kostrzewa, Richard M., John P. Kostrzewa, Russell W. Brown, Przemyslaw Nowak, and University of Silesia Ryszard Brus Medical. "Dopamine Receptor Supersensitivity: Development, Mechanisms, Presentation, and Clinical Applicability." Digital Commons @ East Tennessee State University, 2008. https://doi.org/10.1007/BF03033804.

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Анотація:

The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been learned regarding DARSS. For example, overt D1 DARSS occurs after perinatal destruction of nigrostriatal DA fibers. However, following perinatal destruction of DA innervation, the most-prominent behavioral effects of a D1 agonist are observed after a series of D1 agonist treatmen

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36

Marcott, Pamela F. "Mechanisms of dopamine D2-receptor activation across the striatum." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1502719812531202.

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37

Gallagher, Edward Jude. "Targeted disruption of the neurotensin receptor gene." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241741.

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38

Xiang, Lianbin, Katalin Szebeni, Attila Szebeni, et al. "Dopamine Receptor Gene Expression in Human Amygdaloid Nuclei: Elevated D4 Receptor mRNA in Major Depression." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/8608.

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Previous findings from this laboratory demonstrating changes in dopamine (DA) transporter and D2 receptors in the amygdaloid complex of subjects with major depression indicate that disruption of dopamine neurotransmission to the amygdala may contribute to behavioral symptoms associated with depression. Quantitative real-time RT-PCR was used to investigate the regional distribution of gene expression of DA receptors in the human amygdala. In addition, relative levels of mRNA of DA receptors in the basal amygdaloid nucleus were measured postmortem in subjects with major depression and normal con

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39

Tumova, Katerina. "Uncovering the molecular interplays of dopamine D1-like receptor activation." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26347.

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D1-like dopaminergic receptor family consists of two heptahelical G protein-coupled receptors (GPCRs), termed D1A (or D1) and D1B (or D5). In this study, we have used a functional complementation of chimeric D1-like receptors to address the molecular interplay between the third extracellular loop (EL3) and the cytoplasmic tail (CT) in coordinating the functional properties of D1-like receptors expressed in transfected human embryonic kidney 293 (HEK 293) cells. Our results indicate that ED and CT participate in interfering intramolecular interactions that regulate the total functional receptor

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40

Kruse, Maria Sol. "Plasticity of the dopamine 1 receptor and its signaling pathway /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-652-9/.

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41

Johnson, Christopher Norbert. "The design and synthesis of subtype-selective dopamine receptor antagonists." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266875.

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42

Costanza, Rino Michelangelo. "Dopamine receptor subtype involvement in the behavioural effects of cocaine." Thesis, University of Birmingham, 2000. http://etheses.bham.ac.uk//id/eprint/5890/.

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The relationship between the behavioural effects of cocaine and the increase in dopamine caused by its blockade of dopamine re-uptake has been a major focus of research interest. However, little is known regarding the involvement of recently cloned dopamine D2-like receptor subtypes (D2, D3 and D4) in different cocaine induced behaviours. The purpose of the work described in this thesis was to use a series of behavioural tests to assess dopamine receptor subtype involvement in cocaine's effects. In the first series of experiments, we tested the effects of antagonists selective for receptors wi

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43

Kant, Andrew Charles Mailman Richard B. "Functional selectivity at the D1 dopamine receptor studies using SKF83959 /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2006.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Master of Science in the Curriculum in Toxicology." Discipline: Toxicology; Department/School: Medicine.

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44

Stott, Lisa Alice. "Determination of agonist intrinsic efficacies at the dopamine D2 receptor." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39305/.

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G protein coupled receptor agonists can be described by two parameters; affinity (ability to bind a receptor) and efficacy (ability to activate a receptor once bound). While affinity is now an accessible parameter through binding studies, agonist efficacies have historically been difficult to determine. This is due to the significant system dependence of agonist responses and is particularly true of traditional maximal response and potency measurements. The Black and Leff operational model determines agonist affinity and efficacy estimations directly from functional data. Its measure of effica

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45

Etter, Guillaume. "Role of retinoid X receptor gamma and dopamine receptor D2 in hippocampal and memory functions." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ055.

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Dans ce travail de thèse, j'ai cherché à comprendre les mécanismes de contrôle des fonctions mnésiques par Rxrγ ainsi que l’implication potentielle de la signalisation dopaminergique dans ces mécanismes. Dans ce cadre, j'ai focalisé mon étude sur les fonctions hippocampiques à différent niveaux. J'ai cherché (1) à identifier les populations cellulaires de l'hippocampe exprimant Rxrγ en utilisant des techniques histologiques(immunohistochimie, hybridation in situ) afin de pouvoir (2) étudier les fonctions électrophysiologiques de ces cellules en utilisant la technique du patch-clamp. Pour compr

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46

Voicu, Cristian, and n/a. "Electrophysiological effects in the rat basal ganglia following systemic adenosine A2A receptor stimulation and dopamine D2 receptor blockade." University of Otago. Department of Physiology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080811.155439.

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The difficulty with movement initiation, or akinesia, is a cardinal symptom of Parkinson�s disease (PD) and the loss of dopaminergic cells, affecting the function of the basal ganglia, the thalamus and the motor cortex, has long been documented. From a broader perspective, it has been proposed that akinesia is caused by impaired function in different brain areas, inside and outside the basal ganglia, operating as a �behavioural arrest control system� (Klemm, 2001). Several neurotransmitters seem to modulate the activity of this system and, contrasting the well-known effects of dopamine, the in

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47

Al-Ali, Asmaa M. H. "Understanding the role of dopamine D4 receptor regulation of mesolimbic dopamine function in a rat model of schizophrenia." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/43047.

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The project concentrated on characterising the effect of D4 receptor activation in the context of an animal model relevant to schizophrenia (phencyclidine pretreatment) and elucidating the mechanisms involved. Behavioural studies measured selective attention to motivational stimuli, through measurement of latent inhibition of conditioned learning (LI), and episodic memory measured by novel object recognition (NOR), behaviours which are dysfunctional in schizophrenia. Subchronic PCP pre-treatment for five days disrupted LI and induced behavioural deficits in NOR, replicating previous findings u

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48

Jaworski, Jason Noel. "Effect of dopamine D2/D3 receptor antagonist sulpiride on changes in mesolimbic dopamine produced by amphetamine and ethanol /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008360.

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49

Worrall, S. "The purification of D2Ì² dopamine receptors from bovine striatum." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377448.

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Fowler, Justin Corey Mailman Richard B. "Mechanisms of ligand-receptor interactions of the dopamine D2L receptor and their relation to functional selectivity." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,698.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). " ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Division of Medicinal Chemistry & Natural Products." Discipline: Medicinal Chemistry and Natural Products; Department/School: Pharmacy. On title page "2L" appears as subscript.

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