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Дисертації з теми "Drug-resistant infections"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Delespaux, Vincent F. P. "Improved diagnosis of trypanosome infections and drug resistant T.congolense in livestock." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211060.

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The aim of this thesis was to provide a picture of the trypanosomosis and drug resistance prevalence in Eastern Province of Zambia, to understand the underlying factors of drug resistance (drug use habits), to improve the diagnosis of trypanosomosis in livestock and finally, to improve the diagnosis of isometamidium resistance in T.congolense. After an introductory part where available trypanosomosis and trypanocide resistance diagnostic methods are described and discussed, the body of the thesis is divided in two main sections. In the first section are presented the results of a cross-section

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2

Phee, Lynette. "Unorthodox antimicrobial combination therapies for the treatment of multi-drug resistant Gram-negative infections." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/44695.

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The rise of antimicrobial resistance (AMR) has culminated in the most pressing problem in modern medicine. The situation is most acute with regards to the management of multi- drug resistant Gram-negative infections (MDRGNB) with common infections increasingly untreatable due to rapidly dwindling therapeutic options. A solution to the problem of AMR is unlikely to be easily found, but revisiting and re-purposing existing antimicrobials is a viable approach in the medium term. This study investigated the use of unorthodox antimicrobial combination therapies for the treatment of MDRGNB, with par

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3

Drennon, Michael T. "Drug resistant patterns of invasive Streptococcus pneumoniae infections in the State of Florida in 2003." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001455.

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4

Gounden, Ronald. "Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3282.

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Includes bibliographical references (leaves 42-47).<br>Background: Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and effectiveness with other antimicrobials, particularly the aminoglycosides. Metbods: A retrospective cohort study of patients treated with colistin or tobramycin for A. baumannii infections in intensive care units (ICUs) at Groote Schuur hospital was performed. Colistin was used for A baumannii isolates which were resistant to all other available antimicrobials. Tobramycin was

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5

Dandachi, Iman. "Multi drug resistant organisms in Lebanese livestock." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0286/document.

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De nos jours, l'épidémiologie des bactéries multi-résistantes a évolué et ne se limite plus aux milieux hospitaliers. En effet, les animaux sont désormais considérés comme d’importants réservoirs de bactéries multi-résistantes, notamment des Bacilles à Gram négatif sécréteurs de bêta-lactamases et/ou résistant à la colistine. L'émergence de ces bactéries chez les animaux est due principalement à l’utilisation excessive d’antibiotiques en tant que prophylaxie et facteurs de croissance. Le transfert d’organismes multi-résistants aux antibiotiques provenant d’animaux vers les humains est un probl

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6

Okleberry, Kevin M. "Metabolism of Selected Antiviral Agents in Cells Infected with Drug-Resistant and Wild-Type Strains of Murine Cytomegalovirus." DigitalCommons@USU, 1995. https://digitalcommons.usu.edu/etd/4657.

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Resistance of human viral pathogens to various antiviral drugs is a serious medical problem. Two modes of drug resistance in cytomegalovirus infections have been observed, the first being altered (decreased) drug metabolism by the infected cells, and the second reduced sensitivity of the viral deoxyribonucleic acid polymerase enzyme to the active form of the drug. Mice infected with the murine cytomegalovirus have been used extensively as an animal model for the human cytomegalovirus, and drug-resistant strains in this model have been identified. To better understand the mode of drug resistanc

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7

Zahar, Jean-Ralph. "Epidémiologie et conséquences des infections nosocomiales en réanimation : Impact et conséquences de la résistance bactérienne en réanimation." Thesis, Grenoble, 2012. http://www.theses.fr/2012GRENS004/document.

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Les infections nosocomiales à bactéries multi-résistantes sont en constante augmentation en réanimation. Elles ont des conséquences individuelles et collectives majeures. La mortalité en réanimation et les prolongations des durées de séjour sont les deux principales conséquences individuelles connues à ce jour. Plusieurs facteurs confondants rendent l'interprétation des études difficiles, dont l'état sous jacent du patient, la virulence de la bactérie et l'adéquation thérapeutique. Mesurer la part de chacun de ces facteurs et préciser leur responsabilité respective est indispensable pour mobil

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8

Khachatryan, Artashes Ruben. "Mechanisms responsible for the maintenance of high prevalence of antimicrobial drug resistant Escherichia coli in dairy calves." Online access for everyone, 2005. http://www.dissertations.wsu.edu/Dissertations/Fall2005/a%5Fkhachatryan%5F121205.pdf.

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9

Machado, Lisa Santos. "The inhibitory activity of synthetic compounds and ions against transporters of multi-drug resistant bacteria." Master's thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2011. http://hdl.handle.net/10362/7712.

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RESUMO: Sessenta e três derivados de hidantoína foram utilizados para avaliar possíveis efeitos de modulação na actividade das bombas de efluxo (BE) na Salmonella NCTC 13349 utilizando um método fluorimétrico semi-automático. Nenhum dos compostos apresentaram actividade anti-bacteriana até concentrações de 240 mg/L. Entre todos os compostos, SZ-7 demonstrou possuir propriedades de modulação de effluxo na presença de glucose. Para testar esta actividade, estirpes de Salmonella resistentes à ciprofloxacina, induzidas a elevados níveis de resistência com sobre-expressão de BE, foram expostas ao S

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10

Wilson, Geneva Marion. "Environmental and pharmaceutical risk factors for the transmission of Clostridium difficile and other multi-drug resistant hospital acquired infections." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6885.

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Clostridium difficile (C. difficile) is a gram positive, anaerobic, spore forming bacterium. C. difficile infections are triggered by dysbiosis of the intestinal microbiome linked to age, immune status, and medication; particularly use of antibiotics and proton pump inhibitors (PPI). The spore forming nature of the bacteria gives it the ability to persist in the environment for long periods of time and makes it impervious to many commonly-used hospital cleaning and disinfection products. C. difficile, along with Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Entero

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11

Leangapichart, Thongpan. "Phenotypic and genomic analysis of multi-drug resistant bacteria in travelers." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0183.

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La résistance aux antibiotiques chez les bactéries est un problème majeur mondial du fait de son augmentation. Récemment, la transmission des bactéries résistantes aux humains, aux animaux et à l’environnement sont de plus en plus décrits dans la littérature. Ces dernières années, les voyages internationaux ont augmenté massivement ce qui a permis aux bactéries résistantes de se propager d’un lieu à un autre. Les voyageurs internationaux sont les principaux acteurs de l’acquisition et de la propagation des gènes de résistance aux antibiotiques. Le plus grand rassemblement annuel de personnes c

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12

Kenny, Jacqueline M. "The characterisation of the antimicrobial activity of honey on clinical isolates of multi-drug resistant bacteria implicated in healthcare associated infections." Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/28188/.

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Bacterial resistance to antibiotics has presented increasing challenges in healthcare and the management of infection. This has resulted in alternative and traditional products that are used in other cultures being considered as an alternative to topical antibiotics. Honey, particularly Manuka honey is a product which has gained credibility as an antibacterial agent in a healthcare environment. The aim of this study was to investigate the antimicrobial capacity of syrups and honeys from different floral sources on antibiotic sensitive and resistant bacteria isolated from a clinical environment

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13

Neto, Adelson Lopes da Silva. "Compostos 5-nitro-2-furfurilidênicos com atividade frente à micro-organismos multirresistentes Planejamento, síntese e avaliação da atividade antimicrobiana." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-13042017-163548/.

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A surgimento de bactérias multirresistentes é uma ameaça global. Essas bactérias têm sido associadas com infecções hospitalares, no entanto, diversos casos de infecções multirresistentes adquiridas na comunidade vêm sendo relatadas, o que acendo um alerta quanto a propagação destes micro-organismos para além do ambiente hospitalar. Em todo o mundo o consumo indiscriminado de antibióticos tem aumentado significativamente, sendo este o principal fator para o surgimento e propagação de novas formas de resistência. Outro fator preocupante é a velocidade com que estas novas formas de resistência cr

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14

Affram, Yvonne [Verfasser], and Hans-Georg [Akademischer Betreuer] Kräusslich. "Intracellular DNA Levels of Drug Resistant and Drug Sensitive Human Immunodeficiency Virus Infections and its Correlation with Disease Progression Markers in a Population of Africans / Yvonne Affram ; Betreuer: Hans-Georg Kräusslich." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180610989/34.

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15

Harris, Michelle J. "Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/605.

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Mycobacterium tuberculosis isolates from multiple drug resistant or extensively drug resistant patients show a particular set of mutations in drug targets conferring resistance. However, the selection of drug-resistant strains in vitro yields an alternative set of mutations, thought to result from the cost-benefit associated with drug resistance. Mutations allowing for survival under antibiotic may not be beneficial when presented with the host environment or with a drug-free environment. These fitness effects drive the natural evolution of this bacterium. Using recombineering a large cohor

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16

Locke, Tiffany. "Methicillin-resistant Staphylococcus Aureus in Canadian Hospitals from 1995 to 2007: A Comparison of Adult and Pediatric Inpatients." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26110.

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The literature directly comparing the epidemiology of MRSA among adult and pediatric hospitalized patients is strikingly minimal. The objective of this thesis was to identify any differences between these two patient groups. The Canadian Nosocomial Infections Surveillance Program MRSA data (1995 to 2007: n=1,262 pediatric and 35,907 adult cases) were used to compare MRSA clinical and molecular characteristics and rates. Hospital characteristics were modeled using repeated measures Poisson regressions. The molecular and epidemiological characteristics of MRSA differed significantly between adu

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17

Krüüner, Annika. "Drug-resistant Mycobacterium tuberculosis in Estonia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-455-0/.

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18

Reinato, Lilian Andreia Fleck. "Fatores de risco associados à colonização nasal por Staphylococcus aureus em pessoas vivendo com HIV/aids: um estudo caso-controle." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-17082017-160841/.

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A colonização nasal por Staphylococcus aureus e a infecção pelo HIV representam problemas de saúde pública de preocupação mundial. O objetivo geral foi identificar os fatores de risco para a colonização nasal por Staphylococcus aureus em pessoas vivendo com HIV/aids. Para tanto, foi realizado um estudo tipo caso-controle, com pessoas vivendo com HIV/aids internadas nas unidades especializadas na assistência às doenças infecciosas de um hospital de ensino no interior paulista. A coleta de dados ocorreu de janeiro/2013 a fevereiro/2015, por meio de entrevista individual contemplando dados

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19

Chu, Pui-shan, and 朱佩珊. "Antimicrobial resistant escherichia coli and sequence type 131 in urinary tract infections." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206499.

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Background A pandemic clone, Escherichia coli sequence type 131 (ST131), has been disseminated worldwide and represents an important cause of antimicrobial resistant infections. The spread of this resistant clone has become a great public health concern. Objectives The aims of this study were to investigate the prevalence of ST131 in Escherichia coli isolates from human urinary cultures in Hong Kong and study the antimicrobial phenotypes of ST131. Methodology This study included 340 E. coli clinical urinary isolates obtained from patients in four district hospitals between May 2013

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20

Azores, Molovon Jr Pasagui. "Possible Risk Factors for Multidrug-Resistant Tuberculosis Infection in the Philippines." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3551.

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Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) is a leading cause of morbidity and mortality in the Philippines. The purpose of this study was to gain knowledge about the relationship between potential risk factors and MDR-TB. Risk factors (the independent variables) for MDR-TB (the dependent variable) include previous TB treatment, infection with HIV, exposure to patients with drug-susceptible TB/MDR-TB, delays in diagnosis and treatment, employment status, smoking, imprisonment, alcohol abuse, and poor compliance with TB treatment regimens. The study was based on the epidemiological

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21

Nqini, Babalwa J. "Major spoligotype families of Mycobacterium tuberculosis strains isolated from tuberculosis patients in Port Elizabeth, Eastern Cape, South Africa." Thesis, University of Fort Hare, 2012. http://hdl.handle.net/10353/d1006877.

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South Africa is burdened with tuberculosis (TB) which is aggravated by the concurrent epidemic of HIV as well as the emergence of drug resistance. In most developed countries molecular techniques have been used to look at the dynamics of the TB epidemic however, despite the prevalence that is high in sub-Saharan Africa, there is little data on strain types that are available in Port Elizabeth. This study aims to find the major clades of M. tuberculosis that are circulating in Port Elizabeth. Two hundred MDR-TB DNA samples were obtained from the National Health Laboratory Services TB laboratory

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22

Chou, So-ha, and 周素霞. "Molecular epidemiology of carbapenem-resistant acinetobacter baumanniiin patients and their surrounding environment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48333669.

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Background There has been an increasing awareness of the role of the hospital environment as a reservoir of Acinetobacter baumannii. A. baumannii is an important nosocomial pathogen and is difficult to control due to the increasing cases of resistance to carbapenem. Objectives The objectives of this study areto examine carbapenem-resistant Acinetobacter baumannii (CRAB) positive patients according to their environmental sample to determine how frequently the environment surrounding the patient becomes contaminated and which environmental surfaces are most commonly contaminated. Methodolog

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23

MATTIONI, MARCHETTI VITTORIA. "Multidrug-resistant (MDR) and Extensively Drug-resistant (XDR) Gram-negative bacteria of clinical interest: laboratory diagnosis, clinical management and infection control." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1301308.

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Antimicrobial resistance (AMR) represents one of the major 21st century public health tasks: its increasing has reduced the effective prevention and treatment strategies against infection events. The problem of AMR is especially urgent for Gram-negative bacteria, on which an over-/inappropriate use (incorrect choices, inadequate dosing, and poor adherence to treatment guidelines) of antibiotics have acted as a selective pressure, favouring the survival and multiplication of strains with acquired antibiotic-resistant traits. The aim of my PhD research were: i) to perform an evaluation and chara

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24

Sagwa, Evans Luvaha. "Prevalence and risk factors of adverse events during treatment of drug resistant tuberculosis in a setting of high human immunodeficiency virus co-infection in Namibia : 2009-10." University of the Western Cape, 2012. http://hdl.handle.net/11394/4625.

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Magister Public Health - MPH<br>Namibia is currently coping with a dual burden of human immunodeficiency (HIV) and HIV-associated tuberculosis (TB). In 2010, HIV prevalence was 18.8%, the TB case notification rate was 634 per 100,000 population, while TB/HIV co-infection was 58% in 2009. There were 372 reported cases of drug-resistant TB (DR-TB) in 2009. This study assessed the prevalence, profile and outcome of adverse events (AEs) associated with the treatment of DR-TB, and risk factors for the adverse events. The researcher used a cross-sectional design. Data was collected from the treatmen

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25

Yip, King-sun. "Epidemiology and virulence characteristics of multidrug-resistant escherichia coli from women with acute uncomplicated cystitis." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557443.

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26

Katvars, Laura K. "Novel cationic peptides and polymers in the treatment of methicillin-resistant Staphylococcus aureus and multi-drug resistant Acinetobacter spp. skin infection isolates." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228984.

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27

Strappe, Padraig Michael. "Quantification of proviral load and the distribution of drug resistant mutations in human immunodeficiency virus infection." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271496.

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28

葉景新 and King-sun Yip. "Epidemiology and virulence characteristics of multidrug-resistant escherichia coli from women with acute uncomplicated cystitis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557443.

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29

Van, Ginkel Marney. "Molecular characterisation of the multi-antibiotic resistant bacteria, Klebsiella Pneumoniae isolated from nosocomial infections." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2735.

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Thesis (MSc (Biomedical Technology))--Cape Peninsula University of Technology, 2017.<br>Background: It is well established that Klebsiella pneumoniae (K. pneumoniae) is an opportunistic pathogenic organism that has been frequently identified as the cause of nosocomial and community acquired infections. Furthermore, studies have shown that over the last few decades strains of the genus Klebsiella have systematically developed resistance to numerous antibiotics. Aims and Methods: The primary aim of this study was to investigate the prevalence of K. pneumoniae in nosocomial and community isolates

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30

NABESHIMA, TOSHITAKA, AKIHIRO MOURI, TAKENAO KOSEKI, HIDEKI NISHIYAMA, TAKAYOSHI MAMIYA та YOSHIAKI IKEDA. "RISK FACTORS FOR EXTENDED-SPECTRUM β-LACTAMASEPRODUCING ESCHERICHIA COLI INFECTION IN HOSPITALIZED PATIENTS". Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16027.

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31

Bistline, Kathryn Lou. "Does the inclusion of the cost and burden of adverse drug reactions associated with drug-resistant TB treatment affect the incremental cost-effectiveness of new treatment regimens? A case study from the introduction of bedaquiline in South Africa National TB Programme." Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/28441.

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South Africa has one of the world’s highest burdens of TB, HIV/TB co-infection, and drug-resistant TB. Second-line TB treatment is less effective, more expensive, and more toxic than treatment for drug-sensitive TB. Nearly 1 in every 5 persons who starts treatment for drug-resistant TB in South Africa will die; 1 in every 3 persons who survives treatments experiences permanent, profound hearing loss. For decades there was little progress in TB research, however, and so treatment with old regimens continued despite safety concerns. In 2012 the US and European regulatory authorities approved a n

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32

Nekkab, Narimane. "Spread of hospital-acquired infections and emerging multidrug resistant enterobacteriaceae in healthcare networks : assessment of the role of interfacility patient transfers on infection risks and control measures." Thesis, Paris, CNAM, 2018. http://www.theses.fr/2018CNAM1180/document.

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The spread of healthcare-associated infections (HAIs) and multi-drug resistance in healthcare networks is a major public health issue. Evaluating the role of inter-facility patient transfers that form the structure of these networks may provide insights on novel infection control measures. Identifying novel infection control strategies is especially important for multi-drug resistant pathogens such as Carbapenemase-producing Enterobacteriaceae (CPE) due to limited treatment options. The increasing use of inter-individual contact and inter-facility transfer network data in mathematical modellin

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33

Mason, Rosemarie. "Immunogenicity of drug resistant HIV /." 2005.

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34

Soberano, Lisa Albert. "Models of virus-immune dynamics and drug resistant virus infections." 2006. http://www.lib.ncsu.edu/theses/available/etd-05012006-010714/unrestricted/etd.pdf.

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35

Pogorzelska, Monika. "Institutional and Patient Level Predictors of Multi-Drug Resistant Healthcare-Associated Infections." Thesis, 2011. https://doi.org/10.7916/D84T6RBD.

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Healthcare-associated infections (HAI) caused by multi-drug resistant organisms (MDRO) are an important patient safety concern resulting in a substantial financial and clinical burden. This dissertation aims to contribute to the evidence base on institutional and patient level factors that predict multi-drug resistant infections in the hospital setting. In the first chapter, I review the evidence base on patient-level risk factors for methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI), system-level factors associated with implementation of infection control policie

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36

"Evaluation of novel therapies and innate immune mechanisms against drug resistant wound infections." Tulane University, 2020.

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archives@tulane.edu<br>The rise in prevalence of antimicrobial resistance is one the greatest public health concerns the world is facing today. As the incidence of antimicrobial resistance climbs, persistent wound and surgical site infections are becoming more common, with multidrug resistant Staphylococcus aureus and Pseudomonas aeruginosa being two of the most frequently identified causative agents. To combat these drug resistant infections, there is an urgent need to develop novel therapeutics. In this work, we developed and validated a splinted full thickness murine wound model used in tan

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37

Chan, Ming-Chin, and 詹明錦. "Drug Resistance Mechanism of Extensively Drug-resistant Acinetobacter baumannii (XDRAB) and Risk Factors of Healthcare-associated XDRAB Infections." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/19671294885149958749.

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碩士<br>國立臺灣大學<br>公共衛生碩士學位學程<br>99<br>The emergence of drug-resistant Acinetobacter baumannii (A. baumannii) is now a serious problem in healthcare-associated infections (HAIs) control. Data from Taiwan TINS showed that, while the percentage of carbapenem-resistant A. baumannii (CRAB) in ICU of medical centers/regional hospitals was less than 20% in 2003, it rose to 70% in Q3 2010. The objective of this study is to investage the distribution of integron drug-resistant gene and OXA typing of carbapenemase in extensively drug-resisitant A. baumannii (XDRAB) isolates from XDRAB-HAIs cases (2008~201

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38

Hatyoka, Luiza Miyanda. "Application of cloning in the detection of HIV-1 and drug resistant minority populations." Diss., 2015. http://hdl.handle.net/11602/198.

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Gomes, Antonio. "Computational approaches to deciphering regulatory circuits in mycobacterium tuberculosis from chip-seq data, and developing theoretical strategies to combat drug-resistant infections." Thesis, 2013. https://hdl.handle.net/2144/14240.

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This thesis consists of two related studies directed at aspects of M. tuberculosis biology. The first focuses on deciphering gene-regulatory circuits from ChIP-seq data, and the second focuses on alternative strategies for combatting drug-resistant infections. The first study describes Binding Resolution Amplifier and Cooperative Interaction Locator (BRACIL), a post-peak-caller computational method that predicts transcription-factor (TF) binding sites with high-resolution as well as cooperative TF interactions derived from ChIP-seq data. BRACIL integrates ChIP-seq coverage with motif disco

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Rosa, Daniela Filipa Firmino. "Bringing the biorefinery concept to the health-care facilities: use of industrial by-products against multi-drug resistant bacteria." Master's thesis, 2016. http://hdl.handle.net/10362/82972.

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Multi-drug resistant bacteria (MDRB) are a public health issue worldwide, being alternatives to the conventional failing antibiotherapy required. This fact has turned attention to bioactive compounds with antimicrobial activity features. These bioactives can be extracted from several biomasses sources, namely industrial by-products, within a biorefinery concept. The main objective of this Thesis was the design of a novel antiseptic formulation (AF), based on natural plant extracts, obtained from forest/agriculture industries by-products. The antimicrobial activities of three extracts from di

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"Modulatory effects of antimicrobials on Panton-Valentine Leukocidin gene expression in community-associated methicillin-resistant staphylococcus aureus in vitro and disease severity in vivo in a murine model." 2011. http://library.cuhk.edu.hk/record=b5894719.

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Wong, Kai Yi.<br>Thesis (M.D.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 101-110).<br>Abstracts in English and Chinese.<br>Abstract --- p.4<br>摘要 --- p.7<br>Acknowledgements --- p.9<br>List of Tables --- p.10<br>List of Figures --- p.11<br>List of Abbreviations and Symbols --- p.12<br>Chapter Chapter 1 --- Introduction --- p.14<br>Chapter 1.1 --- Staphylococcus aureus --- p.14<br>Chapter 1.2 --- Methicillin-resistant Staphylococcus aureus (MRSA) --- p.14<br>Chapter 1.2.1 --- Methicillin resistance of MRSA --- p.15<br>Chapter 1.2.2 --- Sta

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Messina, Angeliki Phroso. "A retrospective review of colistin utilization and patient outcomes across four private sector hospitals in South Africa to identify opportunities to optimise colistin stewardship in hospitalised patients with multi-drug resistant Gram-negative infections." Thesis, 2018. https://hdl.handle.net/10539/25414.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfilment of the requirements for the degree of Master of Pharmacy Johannesburg, 2018.<br>The increased prevalence of multi-drug resistant (MDR) Gram-negative infections in critically ill patients has resulted in the re-introduction of colistin as rescue therapy. Various guidelines for colistin administration have led to confusion in establishing the appropriate dose which has potential for adverse consequences including treatment failure or toxicity. Colistin, also known as Polymixin E, is a conc

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Estebesova, Aida. "Systematic Review of Infection Prevention and Control Policies and Nosocomial Transmission of Drug-Resistant Tuberculosis." 2013. http://scholarworks.gsu.edu/iph_theses/312.

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Emerging multidrug-resistant tuberculosis (MDR/XDR-TB) has become a major public health problem, placing millions at risk. Further, nosocomial transmission of MDR/XDR-TB places both patients and healthcare workers at an even higher risk. Effective tuberculosis (TB) infection prevention and control (IPC) policies in high-risk settings must use evidence-based science and should be customized to the setting. However, the growing incidence of MDR/XDR-TB in some global settings raises questions about whether adequate healthcare-related TB IPC policies are in place and whether they are implemented e

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Ramtahal, Melissa Afton. "Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal." Thesis, 2011. http://hdl.handle.net/10413/6294.

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Mycobacterium tuberculosis (MTB) is an airborne pathogen that is easily transmitted from person to person. An intact immune system prevents the organism from causing disease in most individuals. In South Africa, the prevalence of human immunodeficiency virus (HIV) has reached astronomical levels and is now fuelling the tuberculosis (TB) epidemic. Drug resistant MTB strains combined with a weakened host immune system is a lethal combination. Multi-drug resistant (MDR) including extensively drug resistant (XDR) tuberculosis is on the increase, with Tugela Ferry in KwaZulu-Natal South Africa, rep

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黃文彦. "Interferons Reduce the Infection of Drug-Resistant Mutants of Herpes Simplex Virus Type 1." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/56390052142942914604.

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碩士<br>國立成功大學<br>微生物暨免疫學研究所<br>92<br>Herpes simplex virus type 1 infects and establishes latent infection in most humans for life. Acyclovir is the best drug for therapy to inhibit viral replication now, but drug-resistant [thymidine kinase negative (TK-)] mutants are reported frequently in the clinic. Interferons (IFNs), including IFN-alpha, IFN-beta and IFN-gamma, are potent antiviral cytokines. Based on the previous study, combination of IFN-beta and IFN-gamma has the best efficacy to inhibit the replication of wild type virus. In this study, we tested this combination on TK- mutants in

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Huang, Wen-Yen, and 黃文彥. "Interferons Reduce the Infection of Drug-Resistant Mutants of Herpes Simplex Virus Type 1." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/38224254722730065643.

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碩士<br>國立成功大學<br>微生物及免疫學研究所<br>92<br>Herpes simplex virus type 1 infects and establishes latent infection in most humans for life. Acyclovir is the best drug for therapy to inhibit viral replication now, but drug-resistant [thymidine kinase negative (TK-)]mutants are reported frequently in the clinic. Interferons (IFNs), including IFN- , IFN- and IFN- , are potent antiviral cytokines.Based on the previous study, combination of IFN- and IFN- has the best efficacy to inhibit the replication of wild type virus.In this study, we tested this combination on TK- mutants in vitro using Vero cells

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"A study on the molecular and epidemiological characteristics of antibiotic-resistant salmonellae isolated in Hong Kong." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074459.

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A total of 842 single patient isolates of Salmonella spp. from the New Territories East Cluster hospitals, Hong Kong, were collected during 2002 and 2004. The most common Salmonella enterica serotype isolated was S. Enteritidis (29.7%, 250 of 842) followed by S. Typhimurium (13.7%, 115 of 842). The remaining 29.6% (249 of 842) belonged to 44 serotypes and 27.1% (228 of 842) were non-typeable. The majority of isolates were from patients aged two years or younger and were isolated during June to October of each of the three years. The susceptibilities to 19 antimicrobial agents of the 834 isol

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Chen, Ching-Ying, and 陳靖縈. "Mutagenesis of the bacteriolytic lysins produced by bacteriophages infecting multi-drug resistant Acinetobacter baumannii." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/55844890657518165535.

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碩士<br>國立中興大學<br>生命科學系所<br>100<br>Acinetobacter baumannii is a Gram-negative coccobacillus which commonly exists in the environment or in the hospital. It is an opportunistic pathogen and often infects hospitalized patients who are severely ill or debilitated in intensive care units. It causes nosocomial infections, including pneumonia, meningitis, endocarditis, peritonitis, urinary tract infections, and bacteremia. The treatment for A. baumannii infections in the hospital is still based on antibiotics or in combination with a variety of antibiotics. However, in recent years drug-resistant A. b

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Chen, Hong Yi, and 陳虹伊. "The impact of the infection of host cells with drug-resistant Staphylococcus aureus upon antibiotic treatment." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/jedu6b.

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Narayana, Jayaram Lakshmaiah, and 傑朗. "Antimicrobial Peptides: Efficacy and Molecular Mechanism of Action against Multi-Drug Resistant Gastric Pathogen Helicobacter pylori Infection." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/p48gp6.

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博士<br>國立中山大學<br>海洋生物科技博士學位學程<br>103<br>The ongoing development of antibiotic-resistant infections is a major obstacle in ensuring future health and wellbeing. The frequent misuse of antibiotics is one of the reasons behind the development of resistance in pathogenic strains of bacteria. Emergence of multidrug-resistant (MDR) strains of the Gram-negative gastric pathogen Helicobacter pylori (H. pylori) is a global health concern. H. pylori infection is highly prevalent, and has a strong association with various gastric diseases, including gastritis, digestive ulcers, and gastric cancer. Current

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