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Дисертації з теми "Elucidate"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Hauser, Anett. "Chemical Approaches to Elucidate Lysine Phosphorylation." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22287.

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Reversible Phosphorylierung ist die bekannteste posttranslationale Modifikation (PTM) und die O-Phosphomonoester von Serin, Threonin und Tyrosin galten lange als die einzigen relevanten Vertreter. Vor kurzem wurden erste Erkenntnisse über die biologische Relevanz von labilen Phosphorylierungen veröffentlicht, z.B. die Phosphorylierung von Histidin, Arginin und Cystein sowie die Pyrophosphorylierung von Serin und Threonin. Auch die Aufklärung von Phospho-Lysin (pLys) wurde mit der Etablierung einer chemoselektiven Synthese zur Darstellung ortsselektiv phosphorylierter Lysinpeptide und der Entwi

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2

Traylen, Christopher. "To elucidate the Epstein-Barr virus replisome." Thesis, University of Sussex, 2016. http://sro.sussex.ac.uk/id/eprint/59420/.

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Epstein-Barr virus (EBV) is a member of the γ-herpesvirus subfamily of Herpesviridae. EBV is a double stranded DNA virus infecting humans causing a variety of disease from asymptomatic infection to association with certain tumours including Burkitts lymphoma, Hodgkin's disease and nasopharyngeal carcinoma. EBV encodes an immediate-early protein called Zta (BZLF1, EB1, ZEBRA), which is an important transcription factor and replication factor direct in disrupting latency. EBV encodes viral proteins that assemble as a replisome at the viral lytic origin recognition site (Ori-Lyt). Zta binds Ori-L

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3

Hauser, Anett [Verfasser]. "Chemical Approaches to Elucidate Lysine Phosphorylation / Anett Hauser." Berlin : Humboldt-Universität zu Berlin, 2021. http://d-nb.info/1227300778/34.

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4

Guirro, Castellnou Maria. "Multi-omics strategy to elucidate the gut microbiota activity." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/668269.

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La microbiota intestinal s’ha convertit en un factor clau en la patofisiologia de la síndrome metabòlic i les seves comorbiditats associades tals com la hipertensió. El tractament de la síndrome metabòlica és complicat en ser un conjunt de desordres, així doncs els polifenols, com l’hesperidina, poden tenir efectes beneficiosos, com per exemple, disminuint la pressió arterial. A més, alguns factors com la dieta o els antibiòtics poden pertorbar l’equilibri microbiota-hoste i desencadenar una sèrie d’esdeveniments perjudicials. Per a comprendre el paper de la microbiota en la síndrome metabòli

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5

De, Cecco Martin. "Biophysical studies to elucidate structure-activity relationships in β-defensins". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4931.

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β-defensins are a class of mammalian defence peptides with therapeutic potential because of their ability to kill bacteria and attract host immune cells. In order to realise this potential, it is necessary to understand how the functions of these peptides are related to their structures. This thesis presents biophysical analysis of β- defensins and related peptides in conjunction with biological assays. These studies provide new insights into the structure-activity relationships of β-defensins. Ion mobility-mass spectrometry (IM-MS) is used throughout this thesis to probe the tertiary structur

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6

Mernelius, Sara. "Infection control of Staphylococcus aureus : spa typing to elucidate transmission." Doctoral thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-116703.

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Staphylococcus aureus is a commensal of the human flora, primarily colonizing the anterior nares and throat, but it may also cause infections ranging from mild skin and soft tissue infections to severe diseases such as endocarditis and septicemia. S. aureus is also a major nosocomial problem increasing with the worldwide dissemination of methicillin-resistant S. aureus (MRSA). The main vector for bacterial cross-transmission in healthcare settings is the hands of healthcare workers (HCWs). No S. aureus was detected in the air in this thesis demonstrating that transmission through air is not im

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7

Al, Turki Saeed. "Integrated approaches to elucidate the genetic architecture of congenital heart defects." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/245178.

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Congenital heart defects (CHD) are structural anomalies affecting the heart, are found in 1% of the population and arise during early stages of embryo development. Without surgical and medical interventions, most of the severe CHD cases would not survive after the first year of life. The improved health care for CHD patients has increased CHD prevalence significantly, and it has been estimated that the population of adults with CHD is growing ~5% per year. Understanding the causes of CHD would greatly help improve our knowledge of the pathophysiology, family counseling and planning and possibl

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8

Soria, Daniele. "Novel methods to elucidate core classes in multi-dimensional biomedical data." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11179/.

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Breast cancer, which is the most common cancer in women, is a complex disease characterised by multiple molecular alterations. Current routine clinical management relies on availability of robust clinical and pathologic prognostic and predictive factors, like the Nottingham Prognostic Index, to support decision making. Recent advances in highthroughput molecular technologies supported the evidence of a biologic heterogeneity of breast cancer. This thesis is a multi-disciplinary work involving both computer scientists and molecular pathologists. It focuses on the development of advanced computa

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9

Mchem, Rasika Fernando. "The application of fluorescence techniques to elucidate the cell mineral interface." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531202.

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10

Allen, Brian D. (Brian Douglas). "Targeted read-out, analysis, and control to elucidate dynamic-emotional processing." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61940.

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Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 60-62).<br>Many psychological disorders, such as panic disorder, are episodic in nature, with unpredictable onsets and similarly unpredictable durations. That the severe symptoms of these disorders come in waves rather than remain at a level of stasis poses a daunting challenge for pharmacological approaches that lack temporal precision. Here, a set of technologies and approaches

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11

Guauque-Olarte, Sandra. "Genomics to elucidate the molecular basis of calcific aortic valve disease." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/27213.

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Le rétrécissement valvulaire aortique (RVA) est causé par une calcification et une fibrose progressive de la valve aortique. Le risque de développer la maladie augmente avec l’âge. À cause de l'augmentation de l'espérance de vie, le RVA est devenu un problème de santé publique. Le RVA est fatal en absence de traitement médical. Actuellement, la chirurgie est le seul traitement pour le stade sévère de la maladie, mais près de 50% des individus avec RVA n’y sont pas éligibles, principalement due à la présence de comorbidités. Plusieurs processus biologiques ont été associés à la maladie, mais le

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12

Trubl, Gareth. "Pioneering Soil Viromics to Elucidate Viral Impacts on Soil Ecosystem Services." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543425468999981.

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13

Srinivasan, A. "Chickpea –helicoverpa armigera: a system to elucidate plant- insect pest interactions." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2480.

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14

Gliddon, C. M., and n/a. "An attempt to elucidate the role of GABAA receptors in vestibular compensation." University of Otago. Department of Pharmacology & Toxicology, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070427.150754.

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Loss of sensory input from one vestibular labyrinth by unilateral vestibular deafferentation (UVD) results in a severe ocular motor (i.e., spontaneous nystagmus (SN)) and postural syndrome (i.e., yaw head tilt, (YHT) and roll head tilt (RHT)) which compensates over time in a behavioural recovery process known as vestibular compensation. It is generally accepted that the UVD-induced neuronal imbalance in the resting activity between the two vestibular nuclear complexes (VNCs) generates the ocular motor and postural syndrome and that the restoration of the resting activity in the ipsilateral VNC

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15

Tenback, Diederik Egbert. "An epidemiological approach to elucidate dopaminergic mechanisms in tardive dyskinesia in schizophrenia /." Maastricht : Universitaire Pers Maastricht, 2006. http://arno.unimaas.nl/show.cgi?fid=5438.

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16

Windram, Oliver P. "Using a systems biology approach to elucidate transcriptional networks regulating plant defence." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/35680/.

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The phytopathogen Botrytis cinerea is responsible for the devastating grey mould disease that affects hundreds of economically important crop species. B. cinerea represents a necrotrophic pathogen that must kill host tissue before if can consume the nutrients, this distinguishes it from other biotrophic pathogens that exist parasitically. Importantly, B. cinerea is capable of infecting the model plant organism Arabidopsis thaliana. Together with the availability of the sequenced B. cinerea genome and the available molecular tools that now allow fungal genome manipulation makes the pathosystem

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17

De, Motte Rehan Anthony. "A combined experimental and modelling approach to elucidate FeCO3 scale formation kinetics." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16062/.

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In CO2 corrosion, when the local concentrations of Fe2+ and CO32- ions exceed the solubility limit, precipitation of iron carbonate (FeCO3) can occur internally within pipework, forming a protective corrosion barrier at the steel-electrolyte interface. Accurately quantifying the rate of precipitation of this film is important within the oil and gas industry as it can be implemented into corrosion prediction tools to provide a more reliable estimate of anticipated corrosion rates. Existing precipitation rate models are based on measurements conducted in a glass cell in static conditions where t

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18

Jahanbekam, Amirhossein [Verfasser]. "Machine Learning to Elucidate Mechanisms of Human Cognition and Epilepsy / Amirhossein Jahanbekam." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1224270525/34.

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19

Orme, Wesley John. "Cross sections used to elucidate differences in wavelet transforms of ground force reactions." [Boise, Idaho] : Boise State University, 2009. http://scholarworks.boisestate.edu/td/70/.

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20

Dunworth, William P. Caron Kathleen M. "Genetic mouse models elucidate the roles of adrenomedullin in cardiovascular development and physiology." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2832.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Genetics and Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.

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21

Ivwurie, Wisdom. "Source appointment and use of hydropyroysis to elucidate sources of heavily biodegraded hydrocarbons." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422740.

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22

Palmer, Daniel. "Direct selection on lifespan in Drosophila melanogaster to elucidate the mechanisms of longevity." Thesis, Lancaster University, 2018. http://eprints.lancs.ac.uk/129805/.

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Artificial selection can be used to create model organisms tailored for a specific research question. Selection experiments using Drosophila have been a prominent aspect of ageing research over the last 40 years, being used to elucidate the evolutionary roots of ageing, as well as the mechanisms and corollaries by which lifespan extension is achieved in semi-natural populations. With the advent of modern sequencing, and other -omics, technologies, selection experiments offer an exciting opportunity to investigate the molecular and genetic mechanisms of longevity. We selected directly on lifesp

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23

Andrews, Jennifer G. "A qualitative study to elucidate consumer rejection of the practice of coupon use." Thesis, The University of Arizona, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10113252.

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<p> Coupons are a marketing tool used to entice consumers to try a new brand or product in the hopes that they will then become loyal users after trial (Boundless, n.d.). Issuing coupons is a common practice for many businesses because it is relatively inexpensive to begin, and can be used for general advertising purposes in addition to attracting new customers. Digital coupons have been introduced in the last few years and their acceptance is growing, with redemptions in 2010 increasing by 10 times the 2009 rates and projected to increase exponentially with each year (Savings.com, n.d.).

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24

Andrews, Jennifer Gloria. "A Qualitative Study to Elucidate Consumer Rejection of the Practice of Coupon Use." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/612843.

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Coupons are a marketing tool used to entice consumers to try a new brand or product in the hopes that they will then become loyal users after trial (Boundless, n.d.). Issuing coupons is a common practice for many businesses because it is relatively inexpensive to begin, and can be used for general advertising purposes in addition to attracting new customers. Digital coupons have been introduced in the last few years and their acceptance is growing, with redemptions in 2010 increasing by 10 times the 2009 rates and projected to increase exponentially with each year (Savings.com, n.d.). Despi

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25

Bibby, Jaclyn. "Computational studies to elucidate the role of proteins in the prevention of malaria." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/computational-studies-to-elucidate-the-role-of-proteins-in-the-prevention-of-malaria(4370b052-3ec6-488b-802d-efd05e3ff691).html.

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Malaria is a disease that affects half the world's population and is caused by a parasite spread by mosquito. The control of malaria relies on the use of insecticide treated nets to prevent transmission by mosquito bite. Nets alone act as poor barriers to insect bites and the insecticides used to treat the net have a role in killing the insect on contact. As the nets are in frequent contact with people, pyrethroids are the only class of insecticide recommended for use due to its low toxicity to mammals. Insecticide resistance to pyrethroids can occur in insects reducing the effectiveness of th

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26

Sulovari, Arvis. "Integrating Human Population Genetics And Genomics To Elucidate The Etiology Of Brain Disorders." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/781.

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Brain disorders present a significant burden on affected individuals, their families and society at large. Existing diagnostic tests suffer from a lack of genetic biomarkers, particularly for substance use disorders, such as alcohol dependence (AD). Numerous studies have demonstrated that AD has a genetic heritability of 40-60%. The existing genetics literature of AD has primarily focused on linkage analyses in small family cohorts and more recently on genome-wide association analyses (GWAS) in large case-control cohorts, fueled by rapid advances in next generation sequencing (NGS). Numerous A

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27

Park, June-Woo. "Development and validation of novel molecular techniques to elucidate mechanisms of endocrine disruption." Diss., Connect to online resource - MSU authorized users, 2008.

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Thesis (Ph. D.)--Michigan State University. Dept. of Zoology-Environmental Toxicology, 2008.<br>Title from PDF t.p. (viewed on Mar. 30, 2009) Includes bibliographical references. Also issued in print.

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28

Sequera, Mutiozabal Miren Iranzu. "Polyamine signaling pathway during environmental stress: Metabolomic approaches to elucidate spermine down-stream targets." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/315648.

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Environmental stress is increasingly wearing down crop productivity. Nowadays, one of the main aims of plant research is to elucidate tolerance mechanisms to diverse stresses, in order to provide solutions by generating stress-tolerant plants. In regard with this matter, polyamine signaling pathway is of crucial importance. The major polyamines in plants (putrescine, spermidine and spermine) tend to accumulate in response to stress and are associated with a protective role. The trend of their accumulation is related to the stress the plant is sensing; in fact, polyamine biosynthetic pathway is

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29

Boag, Joanne. "The molecular characterisation of childhood acute lymphoblastic leukaemia : gene expression profiles to elucidate leukaemogenesis." University of Western Australia. School of Paediatrics and Child Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0160.

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[Truncated abstract] Acute lymphoblastic leukaemia (ALL) is the most common form of cancer that affects children and the leading cause of child cancer-related death. There have been dramatic improvements in the 5-year event free survival (EFS) for childhood ALL in recent years, with EFS reaching 75-90% for some forms of the disease. Despite this success, treatment for the disease is aggressive with numerous long and short-term side effects. Many cases of ALL are characterised by chromosomal defects including translocations, variations in chromosome number and the deletion of the tumour suppres

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30

Cheok, Meyling. "Pharmacogenomics : gene expression to elucidate determinants of drug response in human acute lymphoblastic leukemia /." Aachen : Shaker, 2003. http://www.gbv.de/dms/bs/toc/372975429.pdf.

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31

Kiddle, Steven J. "Using systems biology approaches to elucidate gene regulatory networks controlling the plant defence response." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/50005/.

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Transcriptional regulation controlling pathogen-responsive gene expression in Arabidopsis is believed to underlie the plant defence response, which confers partial immunity of Arabidopsis to infection by Botrytis cinerea. In this thesis networks of transcriptional regulation mediating the defence response are studied in various ways. First transcriptional regulation was predicted for all genes differentially expressed during B. cinerea infection by development of a novel clustering approach, Temporal Clustering by Affinity Propagation (TCAP). This approach finds groups of genes whose expressio

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32

Curry, Edward William James. "Mining large collections of gene expression data to elucidate transcriptional regulation of biological processes." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/9437.

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A vast amount of gene expression data is available to biological researchers. As of October 2010, the GEO database has 45,777 chips of publicly available gene expression pro ling data from the Affymetrix (HGU133v2) GeneChip platform, representing 2.5 billion numerical measurements. Given this wealth of data, `meta-analysis' methods allowing inferences to be made from combinations of samples from different experiments are critically important. This thesis explores the application of localized pattern-mining approaches, as exemplified by biclustering, for large-scale gene expression analysis. Bi

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33

Yang, Jingchen. "Using the Transient IR Spectroscopy to Elucidate Reaction Mechanisms in Visible Light Photoredox Catalysis:." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:108934.

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Thesis advisor: Matthias M. Waegele<br>Studying the visible light-driven photoredox catalysis coupled with transition-metal complexes is of overriding importance in the development of synthetic strategy. Comparing to conventional thermal catalysis, reactions catalyzed and/ or initiated by photon energy are not only attractive for establishing a more sustainable system, but also for their unique reactivity that has previously been inaccessible. However, one issue draws our attention is that such photoredox catalytic schemes often suffer from a limited substrate scope. To develop more efficient

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34

Boag, Joanne. "The molecular characterisation of childhood acute lymphoblastic leukaemia : gene expression profiles to elucidate leukaemogenesis /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0160.

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35

Lefcheck, Jonathan S. "The use of functional traits to elucidate the causes and consequences of biological diversity." W&M ScholarWorks, 2015. https://scholarworks.wm.edu/etd/1539616736.

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The rapid and global rise in species extinctions has prompted much research into the causes and consequences of biodiversity loss. In the past two decades, efforts have expanded beyond characterizing diversity through numbers of species -- or species richness -- and integrated additional information on how species interact with one another and their environment via functional traits. Functional traits permit a more nuanced exploration of patterns in community structure and composition, and provide a mechanistic basis to link community diversity to ecosystem processes. In this dissertation, I

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36

BLOIS, SYLVAIN SERGE DANIEL. "A Genetic Barcode Approach to Elucidate the Mechanisms of Polyomavirus Persistent Infection in vivo." Doctoral thesis, Università degli Studi di Cagliari, 2019. http://hdl.handle.net/11584/270446.

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Human polyomaviruses are highly prevalent in the general population and establish a long-term asymptomatic infection in healthy individuals. However, a change in the immune status or hormone levels can lead to life-threatening diseases, including tumors. These diseases typically require reactivation from a persistent infection. Currently, a long-standing question in the field of virology is understanding how polyomaviruses undergo a life-long persistent infection in their natural host. Indeed, despite the high seroprevalence of polyomaviruses, little is understood about the mechanisms allowing

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37

Bown, Debbie. "Binge Eating and Impulsivity: The Use of a Delay Discounting Procedure to Elucidate the Relationship." Thesis, University of Southampton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494375.

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38

Stavrianos, E. I. "Studies to elucidate some effects of cytokinins on the reproductive potential of Vicia faba L." Thesis, University of Edinburgh, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.662378.

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Abscission of flowers and loss of pods appears to be part of normal reproductive development in <I>Vicia faba</I> L. The biological processes leading to this loss of reproductive potential are yet to be elucidated, but appear to involve the lack of an adequate cytokinin supply to the reproductive organs. External application of cytokinins was used in this study to help further understand the regulation of reproductive loss in this species. The effect of six cytokinins on the reproductive potential of broad beans, grown under controlled conditions, was studied by local application of the chemic

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39

Bridge, G. E. M. "Using Kaposi's sarcoma-associated herpesvirus to elucidate the role of cellular microRNAs in endothelial biology." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1410931/.

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Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus that is the etiologic agent of Kaposi sarcoma (KS). KS is an angioproliferative neoplasm composed of cells of endothelial origin. For the work described in this thesis, KSHV infection of endothelial cells was used as a tractable model to study the role of microRNAs (miRNAs) in endothelial cell biology. Previous work in the laboratory had identified miRNAs which are either upregulated or downregulated upon KSHV infection of lymphatic endothelial cells (LEC). Target prediction analysis of these miRNAs and cross-comparis

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40

Harris, Nicole. "Using microarrays to elucidate the genetic basis of wood density in sitka spruce and poplar." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/66349/.

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As the global population continues to increase, so will the demand for timber (and other raw materials) for building, construction, and also for the pulping industry. The high demand for wood and the increasing human population mean that natural forests are being lost and degraded. A potential solution to this problem is to improve the productivity of our plantation forests to relieve the pressure on natural forests in terms of sustainable wood production. This project is the first to use newly available microarray technology to study differential gene expression in cambial tissue of high vers

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41

Walliwalagedara, Kiribandage Chamari Hasintha. "PROTEOMIC APPROACHES TO ELUCIDATE MOLECULAR MECHANISMS OF METAL ACCUMULATION IN PLANTS WITH FOCUS ON ARSENIC." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1354365311.

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42

Roach, Tracy Marie. "Use of biochemical approaches to elucidate substrate recognition by archaeal and eukaryotic Thg1 family enzymes." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu158772476842686.

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43

Charton, Lennart [Verfasser]. "Elucidate the important role of peroxisomal transport proteins for plant growth and development / Lennart Charton." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1237104912/34.

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44

Preisler, Julie. "Application of postmortem alzheimer's disease brain to elucidate the involvement of death receptor adaptor signaling." Thesis, Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40738851.

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45

THAIVALAPPIL, PRIYA PADMANABHAN. "IN VITRO STUDIES TO ELUCIDATE THE BIOCHEMICAL FUNCTIONS OF EPSTEIN-BARR VIRUS TEGUMENT PROTEIN BKRF4." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/theses/711.

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Epstein Barr Virus (EBV) is an opportunistic pathogen that causes infectious mononucleosis and associated with Burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative diseases. Throughout the life cycle, EBV genomes attain different levels of chromatinization, transitioning from a fully chromatinized form, which mimics cellular chromatin during latency, through an intermediately chromatinized form during the lytic phase, to a completely non-chromatinized DNA when packaged into the virions. Chromatinization dynamics in vivo requires the coordinated action of multiple proteins inclu

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46

Braun, Katrin. "Comparative study on the nervous system of Tunicata to elucidate tunicate phylogeny and character transformations." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19930.

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Tunicata umfasst 3000 marine Arten, mit sehr unterschiedlichen Lebensstrategien. Als eines der drei großen Taxa innerhalb der Chordata, stellt die Evolution der Tunikaten eine Schlüsselkomponente bei der Aufklärung der Evolution der Chordaten und Cranioten dar. Dafür ist ein Verständnis der Merkmalstransformationen innerhalb der Tunikaten notwendig. Leider sind die internen Verwandtschaftsverhältnisse der fünf großen Tunikatentaxa in verschiedenen molekularphylogenetischen Studien widersprüchlich. Bisher gibt es nur wenige morphologische phylogenetische Analysen. Ein Schwerpunkt dieser Arbeit

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Narkhede, Vijay Sopan. "Kinetic and spectroscopic investigations to elucidate the mechanisms of CO oxidation over Ru and Au catalysts." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980247799.

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Polyakova, Anna. "Applying complementary structural techniques to elucidate structure-function relationships of the bacterial Na+-hydantoin transporter Mhp1." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/11607/.

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Secondary-active trans-membrane transporters couple the ‘downhill’ movement of ions with the ‘uphill’ movement of essential substrates, such as neurotransmitters or metabolites, across the cell membrane. Disruption of these vital processes is linked to some severe diseases in humans, for example Parkinson’s disease. The aim of this project is to investigate the structural basis of the transport mechanism of secondary-active transporters, using the bacterial sodium-hydantoin transporter Mhp1 as a model system, with a combination of X-ray crystallography and small-angle X-ray scattering (SAXS).

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Hawley, Brett. "The Purification and Identification of Interactors to Elucidate Novel Connections in the HEK 293 Cell Line." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23536.

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The field of proteomics studies the structure and function of proteins in a large scale and high throughput manner. My work in the field of proteomics focuses on identifying interactions between proteins and discovering novel interactions. The identification of these interactions provides new information on metabolic and disease pathways and the working proteome of a cell. Cells are lysed and purified using antibody based affinity purification followed by digestion and identification using an HPLC coupled to a mass spectrometer. In my studies, I looked at the interaction networks of several AD

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50

Cheok, Meyling [Verfasser]. "Pharmacogenomics: Gene Expression to Elucidate Determinants of Drug Response in Human Acute Lymphoblastic Leukemia / Meyling Cheok." Aachen : Shaker, 2003. http://d-nb.info/1170541127/34.

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