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Готові списки джерел за темами / Enhancing bone ingrowth / Статті в журналах

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Статті в журналах з теми "Enhancing bone ingrowth"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Wu, Vivian, Marco N. Helder, Nathalie Bravenboer, et al. "Bone Tissue Regeneration in the Oral and Maxillofacial Region: A Review on the Application of Stem Cells and New Strategies to Improve Vascularization." Stem Cells International 2019 (December 30, 2019): 1–15. http://dx.doi.org/10.1155/2019/6279721.

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Bone tissue engineering techniques are a promising alternative for the use of autologous bone grafts to reconstruct bone defects in the oral and maxillofacial region. However, for successful bone regeneration, adequate vascularization is a prerequisite. This review presents and discusses the application of stem cells and new strategies to improve vascularization, which may lead to feasible clinical applications. Multiple sources of stem cells have been investigated for bone tissue engineering. The stromal vascular fraction (SVF) of human adipose tissue is considered a promising single source f

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2

Pius, Alexa K., Masakazu Toya, Qi Gao, Yasemin Sude Ergul, Simon Kwoon-Ho Chow, and Stuart Barry Goodman. "Effects of Aging on Osteosynthesis at Bone–Implant Interfaces." Biomolecules 14, no. 1 (2023): 52. http://dx.doi.org/10.3390/biom14010052.

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Joint replacement is a common surgery and is predominantly utilized for treatment of osteoarthritis in the aging population. The longevity of many of these implants depends on bony ingrowth. Here, we provide an overview of current techniques in osteogenesis (inducing bone growth onto an implant), which is affected by aging and inflammation. In this review we cover the biologic underpinnings of these processes as well as the clinical applications. Overall, aging has a significant effect at the cellular and macroscopic level that impacts osteosynthesis at bone-metal interfaces after joint arthro

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3

Roy, Robert G., Mark D. Markel, Alan J. Lipowitz, Florian Gottsauner-Wolf, Howard F. Taswell, and Edmund Y. S. Chao. "Effect of homologous fibrin adhesive on callus formation and extracortical bone bridging around a porous-coated segmental endoprosthesis in dogs." American Journal of Veterinary Research 54, no. 7 (1993): 1188–96. http://dx.doi.org/10.2460/ajvr.1993.54.07.1188.

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Summary Modular, porous-coated, titanium segmental endoprostheses were implanted bilaterally in the femoral diaphysis of 7 adult mixed-breed dogs. Autogenous bone graft in particle form was placed around the implant and bone. In 1 limb, homologous fibrin adhesive was mixed with the graft in situ before soft tissue closure. The contralateral limb was grafted in identical manner, but without fibrin adhesive, and served as a control. Radiography was performed immediately after surgery and 1, 2, 3, 4, 6, 8, 10, and 12 weeks later to assess callus area and bone remodeling. At 12 weeks, dogs were eu

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4

Ko, S. Y., J. Y. Hong, W. Lee, Y. Y. Chang, K. B. Park, and J. H. Yun. "Osteoconductivity of Porous Titanium Structure on Implants in Osteoporosis." Journal of Dental Research 100, no. 10 (2021): 1178–85. http://dx.doi.org/10.1177/00220345211023724.

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In compromised bone conditions such as osteoporosis, developments of the implant surface are necessary to secure the stability of implants. This study investigated the effect of the surface porous titanium structure (PS) on the osseointegration of implants in osteoporotic bone. Bilateral ovariectomy (OVX) was performed in 4 female beagle dogs to induce osteoporosis for 32 wk. Success of induction was based on the evaluation of bone mineral density by Hounsfield units (HU) in computed tomography images. Posterior teeth in both mandibles were extracted 1 wk after OVX, and a total of 30 implants

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5

Cao, Peng, X. N. Zhang, D. L. Zhang, and Brian Gabbitas. "Mechanical Compatability of Nanostructured Titanium with Human Bone." Materials Science Forum 618-619 (April 2009): 307–10. http://dx.doi.org/10.4028/www.scientific.net/msf.618-619.307.

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With their very low density, excellent biocompatibility, and good mechanochemical properties, titanium alloys have been considered a high-end material for making biomedical devices and instruments. However, they still have some substantial challenges to be overcome. One major problem, which eventually leads to revision surgery, is the implant loosening- a result of tissue migration, formation of wear debris, insufficient interface bonding between bone and implant, and stress shielding. Nanosized features in the material have the potential to provide a solution to these problems. A nanostructur

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6

McCarthy, Colleen, and Gulden Camci-Unal. "Low Intensity Pulsed Ultrasound for Bone Tissue Engineering." Micromachines 12, no. 12 (2021): 1488. http://dx.doi.org/10.3390/mi12121488.

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As explained by Wolff’s law and the mechanostat hypothesis, mechanical stimulation can be used to promote bone formation. Low intensity pulsed ultrasound (LIPUS) is a source of mechanical stimulation that can activate the integrin/phosphatidylinositol 3-OH kinase/Akt pathway and upregulate osteogenic proteins through the production of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). This paper analyzes the results of in vitro and in vivo studies that have evaluated the effects of LIPUS on cell behavior within three-dimensional (3D) titanium, ceramic, and hydrogel scaffolds. We focus speci

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7

Mohan, Saktiswaren, Puvanan Karunanithi, Malliga Raman Murali, et al. "Potential Use of 3D CORAGRAF-Loaded PDGF-BB in PLGA Microsphere Seeded Mesenchymal Stromal Cells in Enhancing the Repair of Calvaria Critical-Size Bone Defect in Rat Model." Marine Drugs 20, no. 9 (2022): 561. http://dx.doi.org/10.3390/md20090561.

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Our previous study evidenced that the 3D CORAGRAF loaded with PLGA microsphere constitutes PDGF-BB can support cell attachment and proliferation and can induce an osteogenic commitment of mesenchymal stromal cells in the in vitro condition. However, how this construct can perform in pathophysiological conditions in terms of repairing critical bone defects is yet to be understood. A study was therefore conducted to investigate the regeneration potential of calvaria critical-size defects using CORAGRAF + PLGA with PDGF-BB + mesenchymal stromal cells (MSCs) in a rat model. A 5 mm critical bone de

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8

Frieler, Sven, Carsten Gebert, Yannik Hanusrichter, Periklis Godolias, and Martin Wessling. "The Modified Harrington Procedure for Metastatic Peri-Acetabular Bone Lesion Using a Novel Highly Porous Titanium Revision Shell with Long Lever Arm Screw." Medicina 60, no. 7 (2024): 1047. http://dx.doi.org/10.3390/medicina60071047.

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Background and Objectives: Peri-acetabular metastases often lead to significant pain and functional impairment. Surgical interventions, including the Harrington procedure, aim to address these challenges. This study evaluates a modified Harrington procedure using the MUTARS® PRS® (Pelvic Revision Shell) with an 8 mm fixation screw for severe acetabular defects resulting from metastatic lesions. Materials and Methods: Retrospective analysis of 12 patients treated between January 2020 and December 2023 was conducted. The procedure involved using the novel MUTARS® PRS® with an 8 mm in diameter do

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9

Baggio, Ana M. P., Yannick M. Sillmann, Pascal Eber, et al. "How Does Ceramic-Based Scaffold Microarchitecture Impact Maxillofacial Bone Regeneration? A Systematic Review of Large Animal Models." Applied Sciences 15, no. 12 (2025): 6899. https://doi.org/10.3390/app15126899.

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Critical-sized bone defects (CSBDs) are injuries that exceed the body’s natural capacity for repair and require external intervention. These defects are particularly challenging in the mandible, often resulting from trauma, tumor resection, or implant-related complications. Effective treatment involves scaffold designs that support vascularization, bone formation, and sufficient mechanical strength. This systematic review aims to assess whether ceramic-based scaffold properties, including porosity, pore size, and macroscopic characteristics, improve vascularization, bone formation, and the mec

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10

Huang, Mao-Suan, Shang-Yang Yu, Pao-Chang Chiang, et al. "Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film." Applied Sciences 10, no. 2 (2020): 645. http://dx.doi.org/10.3390/app10020645.

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In the present study, the piezoelectric aluminum nitride (AlN)/tantalum (Ta) (PAT) thin film was investigated as a biocompatible film and osseointegrated with biomedical devices such as implants. The stress variation on the interaction of cells with the PAT surface was investigated using osteoblast-like cells (MG-63) and fibroblast cells (NIH3T3). A singular behavior was observed on the PAT film with a (002) texture, in which the MG-63 cells were more dispersed and displayed longer and more filopodia than the NIH3T3 cells. Moreover, the MG-63 cells showed ingrowth, adherence, and proliferation

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11

Shevtsov, Maxim A., Natalia Yudintceva, Miralda Blinova, et al. "Application of the skin and bone integrated pylon with titanium oxide nanotubes and seeded with dermal fibroblasts." Prosthetics and Orthotics International 39, no. 6 (2014): 477–86. http://dx.doi.org/10.1177/0309364614550261.

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Background: Direct skeletal attachment of limb prostheses is associated with high rate of transcutaneous infection and loosening of the fixture in the medullary canal prompting for careful assessment of various means for enhancing the skin-device and bone-device interface. The skin and bone integrated pylon system constitutes a technological platform for different modifications being evaluated previously. Objectives: The current study assessed the combination of nano-treatment skin and bone integrated pylon with its pre-seeding with dermal fibroblasts. We hypothesized that this combination wil

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12

Hamdi, Dunia Abdulsahib, and Fatima Mowafaq Khider. "Design and Analysis of Composite Biomaterial Bone Graft Plate." Al-Nahrain Journal for Engineering Sciences 26, no. 4 (2024): 278–85. http://dx.doi.org/10.29194/njes.26040278.

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The mixing technique was applied in this study to enhance the strength performance of the cement. The addition of 3% by weight of hydroxyapatite (HA) nanoparticles were mixed with 97% polymethyl methacrylate (PMMA) acrylic polymer, which has a nano size to serve as the matrix material. The surface roughness and continuous porosity of the bone cement were found to be slightly increased by the incorporation of nanoparticles, which enhanced bone-implant osseointegration and ingrowth. Atomic force microscopy (AFM) analysis revealed that the addition of hydroxyapatite (HAp) nanoparticles resulted i

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13

Laubach, Markus, Frank Hildebrand, Sinduja Suresh, et al. "The Concept of Scaffold-Guided Bone Regeneration for the Treatment of Long Bone Defects: Current Clinical Application and Future Perspective." Journal of Functional Biomaterials 14, no. 7 (2023): 341. http://dx.doi.org/10.3390/jfb14070341.

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Анотація:

The treatment of bone defects remains a challenging clinical problem with high reintervention rates, morbidity, and resulting significant healthcare costs. Surgical techniques are constantly evolving, but outcomes can be influenced by several parameters, including the patient’s age, comorbidities, systemic disorders, the anatomical location of the defect, and the surgeon’s preference and experience. The most used therapeutic modalities for the regeneration of long bone defects include distraction osteogenesis (bone transport), free vascularized fibular grafts, the Masquelet technique, allograf

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14

Rajzer, Izabella, Anna Kurowska, Anna Nikodem, et al. "3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair." Materials 18, no. 8 (2025): 1826. https://doi.org/10.3390/ma18081826.

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Анотація:

A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer will provide a porous structure for tissue ingrowth. Graphene was integrated into the scaffold for its antibacterial properties, and the drug Osteogenon® (OST) was added to promote bone tissue regeneration. The composite scaffolds were subjected to comprehensive physical, thermal, and mechanical evaluations. Additionally, their biological

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15

Huynh, Vivian, Ngan K. Ngo, and Teresa D. Golden. "Surface Activation and Pretreatments for Biocompatible Metals and Alloys Used in Biomedical Applications." International Journal of Biomaterials 2019 (June 2, 2019): 1–21. http://dx.doi.org/10.1155/2019/3806504.

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Анотація:

To improve the biocompatibility of medical implants, a chemical composition of bone-like material (e.g., hydroxyapatite) can be deposited on the surface of various substrates. When hydroxyapatite is deposited on surfaces of orthopedic implants, several parameters must be addressed including the need of rapid bone ingrowth, high mechanical stability, corrosion resistance, biocompatibility, and osseointegration induction. However, the deposition process can fail due to poor adhesion of the hydroxyapatite coating to the metallic substrate. Increasing adhesion by enhancing chemical bonding and min

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16

Chen, Yu-San, Po-Kuei Wu, Wei-Che Tsai, and Chun-Li Lin. "Enhancing bone ingrowth and mechanical bond strength at the titanium alloy 3D-printed implant-bone interface through advanced lattice designs and growth factor integration." International Journal of Bioprinting, February 6, 2025, 8115. https://doi.org/10.36922/ijb.8115.

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Patient-specific titanium alloy 3D-printed implants often face challenges such as stress shielding and insufficient osseointegration. This study investigated the effects of lattice designs and growth factor-enriched sticky bone on bone ingrowth and mechanical bond strength at the implant-bone interface of the large-scale bone defect at distal femur condyle of New Zealand rabbit model. Hollow cylindrical implants (12 mm length, 6 mm outer, 2 mm inner diameters) with diamond (DU) and randomly deformed spherical (YMR) lattices were designed and implanted into rabbit femoral condyles. Platelet-ric

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17

Ghamor-Amegavi, Edem Prince, Fei Xu, and Yu Chong. "Fabrication of Monophasic Strontium Doped Calcium Silicate Granules With Enhanced Osteogenic Performance In The Reconstruction Of Rabbit Bone Defect." Acta of Bioengineering and Biomechanics 25, no. 3 (2023). http://dx.doi.org/10.37190/abb-02325-2023-02.

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Purpose Advances in the design and manufacturing of novel synthetic bioactive scaffolds as bone substitute in bone reconstruction are at the forefront of orthopedic study due to their excellent biological performances. However, fabricating bioactive scaffolds with similar osteogenic and mechanical properties of a natural bone still remains a challenge. Our aim was to produce functional bioactive scaffolds with biologically interactive ions, microstructure for cell proliferation and a suitable biodegradation rate in critical-size bone defect. Methods The Sr-CaSi group had complete bone healing

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18

Lee, Hyeongjin, Carlos Kengla, Han Su Kim, et al. "Enhancing Craniofacial Bone Reconstruction with Clinically Applicable 3D Bioprinted Constructs." Advanced Healthcare Materials, October 31, 2023. http://dx.doi.org/10.1002/adhm.202302508.

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AbstractMedical imaging and 3D bioprinting can be used to create patient‐specific bone scaffolds with complex shapes and controlled inner architectures. This study investigated the effectiveness of a biomimetic approach to scaffold design by employing geometric control. The biomimetic scaffold with a dense external layer showed improved bone regeneration compared to the control scaffold. New bone filled the defected region in the biomimetic scaffolds, while the control scaffolds only presented new bone at the boundary. Histological examination also showed effective bone regeneration in the bio

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19

Luo, Zhen, Qingqian Zhao, Yiming Zhang, et al. "Coral‐Inspired Bioactive Porous Adhesive for Fractured Bone Repair." Advanced Functional Materials, June 2025. https://doi.org/10.1002/adfm.202507592.

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AbstractBone adhesives capable of replacing traditional invasive materials represent a revolutionary advancement in orthopedic surgery. However, the efficiency of commercial bone adhesives is often limited due to their inability to promote the ingrowth of bone‐related cells, a crucial process for the effective integration of fractured bone and the implant. The strategy of in situ pore formation, coupled with intrinsic microenvironment remodeling, has shown promise in enhancing bone fracture healing. Herein, inspired by the natural process of coral skeleton formation, a novel bone adhesive is d

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20

Kadiyala, S., M. Richards, B. Dahiyat, J. D. Michelson, and K. W. Leong. "Poly(Phosphoesters) as Bioabsorbable Osteosynthetic Materials." MRS Proceedings 252 (1991). http://dx.doi.org/10.1557/proc-252-311.

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ABSTRACTPolymeric prosthetic devices enjoy the advantage of tailor-made properties. In particular bioabsorbable polymers possess distinct advantages. In orthopedic applications, most osteosynthesis has been achieved using metallic devices to stabilize fixation of bony fragments. The different elastic moduli of the metallic implants versus that of bone often causes cortical bone to atrophy. The theoretical advantage of gradual load transfer from the fixation device to the bone and the elimination of surgical removal after the healing of a fracture make an absorbable osteosynthetic material extr

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21

Cho, Eunshinae, Yi Qiao, Changan Chen, et al. "Injectable FHE+BP composites hydrogel with enhanced regenerative capacity of tendon-bone interface for anterior cruciate ligament reconstruction." Frontiers in Bioengineering and Biotechnology 11 (February 23, 2023). http://dx.doi.org/10.3389/fbioe.2023.1117090.

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Features of black phosphorous (BP) nano sheets such as enhancing mineralization and reducing cytotoxicity in bone regeneration field have been reported. Thermo-responsive FHE hydrogel (mainly composed of oxidized hyaluronic acid (OHA), poly-ε-L-lysine (ε-EPL) and F127) also showed a desired outcome in skin regeneration due to its stability and antibacterial benefits. This study investigated the application of BP-FHE hydrogel in anterior cruciate ligament reconstruction (ACLR) both in in vitro and in vivo, and addressed its effects on tendon and bone healing. This BP-FHE hydrogel is expected to

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22

Ferguson, Ben M., Jonathan R. Clark, and Qing Li. "Scaffold geometries designed to promote bone ingrowth by enhancing mechanobiological stimulation and biotransportation - a multiobjective optimisation approach." Journal of the Mechanical Behavior of Biomedical Materials, December 2024, 106883. https://doi.org/10.1016/j.jmbbm.2024.106883.

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23

Wang, Tao, Jiaxiang Bai, Min Lu, et al. "Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking." Nature Communications 13, no. 1 (2022). http://dx.doi.org/10.1038/s41467-021-27816-1.

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AbstractImmune response and new tissue formation are important aspects of tissue repair. However, only a single aspect is generally considered in previous biomedical interventions, and the synergistic effect is unclear. Here, a dual-effect coating with immobilized immunomodulatory metal ions (e.g., Zn2+) and osteoinductive growth factors (e.g., BMP-2 peptide) is designed via mussel adhesion-mediated ion coordination and molecular clicking strategy. Compared to the bare TiO2 group, Zn2+ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL

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24

Peng, Haitao, Jianxiao Li, Yanan Xu, and Guoyu Lv. "Icaritin Enhancing Bone Formation Initiated by Sub-Microstructured Calcium Phosphate Ceramic for Critical Size Defect Repair." Frontiers in Materials 7 (December 11, 2020). http://dx.doi.org/10.3389/fmats.2020.598057.

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Adequate bone tissue regeneration has been challenging to achieve at critical-sized bone defects caused by disease. Bone tissue engineering using a combination of scaffolds and bioactive factors provides new hope for the treatment of this extreme condition. Icaritin, a herb-derived chemical, has shown its ability to enhance bone formation both in vitro and in vivo, and it has been found that sub-micron surface structure instructs bone formation in calcium phosphate ceramics (CaPs). Here, we evaluated the possibility of using a submicron surface structured CaP ceramic as the carrier of icaritin

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25

Dou, Xinyu, Xiao Liu, Yu Liu, et al. "Biomimetic Porous Ti6Al4V Implants: A Novel Interbody Fusion Cage via Gel‐Casting Technique to Promote Spine Fusion." Advanced Healthcare Materials, July 19, 2024. http://dx.doi.org/10.1002/adhm.202400550.

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AbstractAn interbody fusion cage (Cage) is crucial in spinal decompression and fusion procedures for restoring normal vertebral curvature and rebuilding spinal stability. Currently, these Cages suffer from issues related to mismatched elastic modulus and insufficient bone integration capability. Therefore, a gel‐casting technique is utilized to fabricate a biomimetic porous titanium alloy material from Ti6Al4V powder. The biomimetic porous Ti6Al4V is compared with polyetheretherketone (PEEK) and 3D‐printed Ti6Al4V materials and their respective Cages. Systematic validation is performed through

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26

Zhao, Heng, Shi Shen, Lu Zhao, Yulin Xu, Yang Li, and Naiqiang Zhuo. "3D printing of dual-cell delivery titanium alloy scaffolds for improving osseointegration through enhancing angiogenesis and osteogenesis." BMC Musculoskeletal Disorders 22, no. 1 (2021). http://dx.doi.org/10.1186/s12891-021-04617-7.

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Abstract Background The repair of large bone defects is a great challenge for orthopedics. Although the development of three-dimensional (3D) printed titanium alloy (Ti6Al4V) implants with optimized the pore structure have effectively promoted the osseointegration. However, due to the biological inertia of Ti6Al4Vsurface and the neglect of angiogenesis, some patients still suffer from postoperative complications such as dislocation or loosening of the prosthesis. Methods The purpose of this study was to construct 3D printed porous Ti6Al4V scaffolds filled with bone marrow mesenchymal stem cell

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27

Namvar, Arman, Bill Lozanovski, David Downing, et al. "Finite element analysis of patient-specific additive-manufactured implants." Frontiers in Bioengineering and Biotechnology 12 (May 9, 2024). http://dx.doi.org/10.3389/fbioe.2024.1386816.

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Introduction: Bone tumors, characterized by diverse locations and shapes, often necessitate surgical excision followed by custom implant placement to facilitate targeted bone reconstruction. Leveraging additive manufacturing, patient-specific implants can be precisely tailored with complex geometries and desired stiffness, enhancing their suitability for bone ingrowth.Methods: In this work, a finite element model is employed to assess patient-specific lattice implants in femur bones. Our model is validated using experimental data obtained from an animal study (n = 9).Results: The results demon

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Chang, Chun-Ming, Pei-Chun Wong, Sin-Liang Ou, Chih-En Ko, and Yu-Tzu Wang. "Optimizing implant lattice design for large distal femur defects: Stimulating interface bone growth to enhance osseointegration." International Journal of Bioprinting, March 21, 2024, 2590. http://dx.doi.org/10.36922/ijb.2590.

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Large bone defects in the distal femur present a significant challenge due to the lack of inherent self-healing capabilities. Traditional approaches, such as utilizing polymethyl methacrylate (PMMA) in conjunction with a plate for distal femur reconstruction, have shown unsatisfactory osseointegration outcome, which leads to complications. To address this challenge, this study focuses on developing a lattice-structured implant for reconstructing distal femoral bone defects. The lattice geometry is based on the cuboctahedron lattice, with its design optimized through the adjustment of pillar di

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Li, Nayun, Jinyu Wang, Guangxia Feng, et al. "Advances in Biomaterials for Oral-Maxillofacial Bone Regeneration: Spotlight on Periodontal and Alveolar Bone Strategies." Regenerative Biomaterials, July 4, 2024. http://dx.doi.org/10.1093/rb/rbae078.

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Abstract The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing the repair and regeneration of oral-maxillofacial bone defects. Numerous characteristics should be noticed in oral-maxillofacial bone repair, such as irregular morphology of bone defects, homeostasis between hosts and microorganisms in the oral cavity, and complex periodontal structures that facilitate epithelial ingrowth. Therefore, oral-maxillofacial bone repair necessitates restoration materials that adhere to stringent

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Li, Nayun, Guangxia Feng, Yuqing Liu, et al. "Porous Microspheres Loading Small Molecule Targeting REV‐ERBs Modulate Inflammatory Cytokines Fluctuations to Promote Periodontal Bone Regeneration." Advanced Healthcare Materials, June 25, 2025. https://doi.org/10.1002/adhm.202500867.

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AbstractAlveolar bone loss, mainly due to periodontitis and local inflammation, poses a great challenge for current bone graft materials. To address this issue, we introduce PLGA‐S@Gel‐SeHA, a microsphere composed of Poly(lactic‐co‐glycolic acid) (PLGA), gelatin mineralized selenium‐doped hydroxyapatite (Gel‐SeHA) and STL1267 (S), which target circadian rhythm gene REV‐ERBs (nuclear recerptor subfamily 1, group D, NR1D), to maintain inflammatory cytokine homeostasis for alveolar bone repair. Synthesized via iso‐density emulsion and microfluidics, the PLGA‐S@Gel‐SeHA microspheres are of uniform

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Wang, Tao, Ziqing Yu, Shaozhang Lin, et al. "3D-printed Mg-incorporated PCL-based scaffolds improves rotator cuff tendon-bone healing through regulating macrophage polarization." Frontiers in Bioengineering and Biotechnology 12 (July 8, 2024). http://dx.doi.org/10.3389/fbioe.2024.1407512.

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Introduction: Rotator cuff tear (RCT) is a common shoulder injury impacting mobility and quality of life, while traditional surgeries often result in poor healing. Tissue engineering offers a promising solution, with poly (ε-caprolactone) (PCL) being favored due to its slow degradation, biocompatibility, and non-toxicity. However, PCL lacks sufficient compression resistance. Incorporating Mg, which promotes bone growth and has antibacterial effects, could enhance RCT repair.Methods: The Mg-incorporated PCL-based scaffolds were fabricated using a 3D printing technique. The scaffolds were incorp

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Haitao, Xu, Li Siyuan, Guo Sutong, et al. "Preparation of Cu²⁺/TA/HAP composite coating with anti-bacterial and osteogenic potential on 3D-printed porous Ti alloy scaffolds for orthopedic applications." Open Life Sciences 19, no. 1 (2024). http://dx.doi.org/10.1515/biol-2022-0826.

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Abstract Because of stress shielding effects, traditional titanium (Ti) alloy scaffolds have a high elastic modulus, which might promote looseness and bone disintegration surrounding the implant, increasing the likelihood of a second surgery. In contrast, 3D-printed porous Ti alloy scaffolds can reduce the scaffold weight while enhancing biocompatibility. Further, these scaffolds’ porous nature allows bone tissue ingrowth as well as strong pore connectivity, which can improve nutrient absorption. Nevertheless, bare Ti alloy implants may fail because of inadequate bone integration; hence, addin

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Villegas, Martin, Yuxi Zhang, Maryam Badv, et al. "Enhancing osseointegration and mitigating bacterial biofilms on medical-grade titanium with chitosan-conjugated liquid-infused coatings." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-09378-4.

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AbstractTitanium alloys, in particular, medical-grade Ti-6Al-4 V, are heavily used in orthopaedic applications due to their high moduli, strength, and biocompatibility. Implant infection can result in biofilm formation and failure of prosthesis. The formation of a biofilm on implants protects bacteria from antibiotics and the immune response, resulting in the propagation of the infection and ultimately resulting in device failure. Recently, slippery liquid-infused surfaces (LIS) have been investigated for their stable liquid interface, which provides excellent repellent properties to suppress

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Hede, Kris T. C., Bjørn B. Christensen, Morten L. Olesen, et al. "Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model." CARTILAGE, July 26, 2021, 194760352110297. http://dx.doi.org/10.1177/19476035211029707.

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Objective This study evaluated the effects of mesenchymal stem cell-extracellular vesicles (MSC-EVs) on chondrocyte proliferation in vitro and on cartilage repair in vivo following bone marrow stimulation (BMS) of focal chondral defects of the knee. Methods Six adult Göttingen minipigs received 2 chondral defects in each knee. The pigs were randomized to treatment with either BMS combined with MSC-EVs or BMS combined with phosphate-buffered saline (PBS). Intraarticular injections MSC-EVs or PBS were performed immediately after closure of the surgical incisions, and at 2 and 4 weeks postoperati

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Bohart, Zachary, Charles Cassidy, David Merrill, et al. "Temporary Botulinum Immobilization of Residuum Muscles for Facilitation of the Initial Ingrowth of Skin to the Porous Skin and Bone Integrated Pylon in the Technology of Direct Skeletal Attachment: Large Animal Model." Frontiers in Rehabilitation Sciences 3 (March 3, 2022). http://dx.doi.org/10.3389/fresc.2022.758238.

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Enhancing the technology of bone-anchored limb prosthetics, we present a modified porcine model for developing an infection-free integration between the skin and a percutaneous bone implant. The deeply porous Skin and Bone Integrated Pylon (SBIP) presented an infection-free skin-implant interface both after implantation into the dorsum and after implantation into the residuum after below-knee amputation. However, deep ingrowth of skin into the porous cladding of the SBIP was achieved better in the dorsal procedure, while implantation to the residuum sometimes developed a stoma, probably due to

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Putzer, David, Christoph Ammann, Débora Coraça-Huber, Ricarda Lechner, Werner Schmölz, and Michael Nogler. "The Influence of Liquids on the Mechanical Properties of Allografts in Bone Impaction Grafting." BIOPRESERVATION AND BIOBANKING, January 1, 2017. https://doi.org/10.1089/bio.2017.0003.

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Allografts are used to compensate for bone defects resulting from revision surgery, tumor surgery, and reconstructive bone surgery. Although it is well known that the reduction of fat content of allografts increases mechanical properties, the content of liquids with a known grain size distribution has not been assessed so far. The aim of the study was to compare the mechanical properties of dried allografts (DA) with allografts mixed with a saline solution (ASS) and with allografts mixed with blood (AB) having a similar grain size distribution. Fresh-frozen morselized bone chips were cleaned c

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