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Добірка наукової літератури з теми "Epitope"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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Статті в журналах з теми "Epitope"

1

Mylin, Lawrence M. "Context-Dependent Immunogenicity of an S206G-Substituted H-2Db-Restricted Simian Virus 40 Large T Antigen Epitope I Variant." Journal of Immunology 162, no. 4 (1999): 2171–79. http://dx.doi.org/10.4049/jimmunol.162.4.2171.

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Abstract SV40 large tumor Ag (Tag) contains four H-2b-restricted (I, II/III, IV, and V) CTL epitopes. A hierarchy exists among these CTL epitopes. CTL directed against epitopes I, II/III, and IV are readily detected following immunization of H-2b mice with SV40, Tag-transformed syngeneic cells, or a vaccinia recombinant that expresses full-length Tag, while epitope V-specific CTL are not. The mechanisms that define this hierarchy remain unknown. Initial studies have shown that the locations of epitopes I and V within SV40 Tag do not determine the immunological potencies of these epitopes. Like

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2

Potocnakova, Lenka, Mangesh Bhide, and Lucia Borszekova Pulzova. "An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction." Journal of Immunology Research 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/6760830.

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Identification of B-cell epitopes is a fundamental step for development of epitope-based vaccines, therapeutic antibodies, and diagnostic tools. Epitope-based antibodies are currently the most promising class of biopharmaceuticals. In the last decade, in-depth in silico analysis and categorization of the experimentally identified epitopes stimulated development of algorithms for epitope prediction. Recently, various in silico tools are employed in attempts to predict B-cell epitopes based on sequence and/or structural data. The main objective of epitope identification is to replace an antigen

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3

Moriki, Takanori, Ichiro N. Maruyama, Yusuke Yamaguchi, Atsuko Igari, Yasuo Ikeda, and Mitsuru Murata. "Identification of ADAMTS13 Epitopes Required for Binding to von Willebrand Factor Using Lambda Phage Surface Display." Blood 110, no. 11 (2007): 2707. http://dx.doi.org/10.1182/blood.v110.11.2707.2707.

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Abstract The metalloprotease ADAMTS13 cleaves multimeric von Willebrand factor (VWF) to regulate VWF-mediated thrombus formation. We planned to search core epitopes of ADAMTS13 that is required for its binding to VWF. We constructed a random cDNA fragment library expressing various peptides of ADAMTS13 on the surface of lambda phage and screened the library using immobilized VWF as a probe. After the first screening, the C-terminus of the spacer domain from Arg670 to Glu684 (termed as epitope-1) and the middle of the cysteine-rich domain from Arg484 to Arg507 (epitope-2) were determined as epi

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4

Tornyi, Ilona, Jozsef Lazar, Aladar Pettko-Szandtner, Eva Hunyadi-Gulyas, and Laszlo Takacs. "Epitomics: Analysis of Plasma C9 Epitope Heterogeneity in the Plasma of Lung Cancer Patients and Control Subjects." International Journal of Molecular Sciences 24, no. 18 (2023): 14359. http://dx.doi.org/10.3390/ijms241814359.

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The human proteome is more complex than the genetic code predicts it to be. Epitomics, or protein epitome profiling, is a tool for understanding sub-protein level variation. With the ultimate goal to explore C9 proteoforms and their relevance to lung cancer, here we report plasma C9 epitope-associated molecular heterogeneity in plasma samples of lung cancer patients and control subjects. We show three C9 epitopes (BSI0449, BSI0581, BSI0639) with markedly different association with lung cancer (“unaltered”, “upregulated” and “downregulated”). In order to exclude confounding effects, we show fir

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5

De-Simone, Salvatore G., Paloma Napoleão-Pêgo, Guilherme C. Lechuga, et al. "Mapping IgA Epitope and Cross-Reactivity between Severe Acute Respiratory Syndrome-Associated Coronavirus 2 and DENV." Vaccines 11, no. 12 (2023): 1749. http://dx.doi.org/10.3390/vaccines11121749.

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Background: The newly introduced COVID-19 vaccines have reduced disease severity and hospitalizations. However, they do not significantly prevent infection or transmission. In the same context, measuring IgM and IgG antibody levels is important, but it does not provide information about the status of the mucosal immune response. This article describes a comprehensive mapping of IgA epitopes of the S protein, its cross-reactivity, and the development of an ELISA-peptide assay. Methods: IgA epitope mapping was conducted using SPOT synthesis and sera from RT-qPCR COVID-19-positive patients. Speci

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6

Soto, Luis Fernando, David Requena, and Juan Ignacio Fuxman Bass. "Epitope-Evaluator: An interactive web application to study predicted T-cell epitopes." PLOS ONE 17, no. 8 (2022): e0273577. http://dx.doi.org/10.1371/journal.pone.0273577.

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Multiple immunoinformatic tools have been developed to predict T-cell epitopes from protein amino acid sequences for different major histocompatibility complex (MHC) alleles. These prediction tools output hundreds of potential peptide candidates which require further processing; however, these tools are either not graphical or not friendly for non-programming users. We present Epitope-Evaluator, a web tool developed in the Shiny/R framework to interactively analyze predicted T-cell epitopes. Epitope-Evaluator contains six tools providing the distribution of epitopes across a selected set of MH

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7

Mylin, Lawrence M., Todd D. Schell, Debra Roberts, et al. "Quantitation of CD8+ T-Lymphocyte Responses to Multiple Epitopes from Simian Virus 40 (SV40) Large T Antigen in C57BL/6 Mice Immunized with SV40, SV40 T-Antigen-Transformed Cells, or Vaccinia Virus Recombinants Expressing Full-Length T Antigen or Epitope Minigenes." Journal of Virology 74, no. 15 (2000): 6922–34. http://dx.doi.org/10.1128/jvi.74.15.6922-6934.2000.

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ABSTRACT The cytotoxic T-lymphocyte response to wild-type simian virus 40 large tumor antigen (Tag) in C57BL/6 (H2b ) mice is directed against three H2-Db -restricted epitopes, I, II/III, and V, and oneH2-Kb -restricted epitope, IV. Epitopes I, II/III, and IV are immunodominant, while epitope V is immunorecessive. We investigated whether this hierarchical response was established in vivo or was due to differential expansion in vitro by using direct enumeration of CD8+ T lymphocytes with Tag epitope/major histocompatibility complex class I tetramers and intracellular gamma interferon staining.

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8

Ando, Takao, Rauf Latif, Samira Daniel, Katsumi Eguchi, and Terry F. Davies. "Dissecting Linear and Conformational Epitopes on the Native Thyrotropin Receptor." Endocrinology 145, no. 11 (2004): 5185–93. http://dx.doi.org/10.1210/en.2004-0789.

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Abstract The TSH receptor (TSHR) is the primary antigen in Graves’ disease. In this condition, autoantibodies to the TSHR that have intrinsic thyroid-stimulating activity develop. We studied the epitopes on the native TSHR using polyclonal antisera and monoclonal antibodies (mAbs) derived from an Armenian hamster model of Graves’ disease. Of 14 hamster mAbs analyzed, five were shown to bind to conformational epitopes including one mAb with potent thyroid-stimulating activity. Overlapping conformational epitopes were determined by cell-binding competition assays using fluorescently labeled mAbs

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9

Singh, Niraj K., Anuj Tyagi, Sumit Singhal, Anjay, Yogendra Singh Jadoun, and Anuradha Kumari. "Bio-Computational Prediction of Novel Epitopes on VP2 Protein of Infectious Bursal Disease Virus." Journal of Advances in Microbiology 24, no. 5 (2024): 26–39. http://dx.doi.org/10.9734/jamb/2024/v24i5824.

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Aim: Recently, many viral Immunogenic peptides or epitopes have been used as potential vaccine and also immuno-diagnostic candidates. In this study, we predicted different epitopic peptides on VP2 protein of infectious bursal disease virus (IBDV) using bioinformatics tools, which can be potential vaccine as well as diagnostic candidate for IBD, in future. Study Design: In the present study, B-cell epitopes (linear or continuous, and conformational) and T-cell epitopes were predicted on VP2 protein. Place and Duration of Study: Bihar Animal Sciences University, Patna, and Guru Angad Dev Veterin

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10

Lim, Li Cen, Yee Ying Lim, and Yee Siew Choong. "Data curation to improve the pattern recognition performance of B-cell epitope prediction by support vector machine." Pure and Applied Chemistry 93, no. 5 (2021): 571–77. http://dx.doi.org/10.1515/pac-2020-1107.

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Abstract B-cell epitope will be recognized and attached to the surface of receptors in B-lymphocytes to trigger immune response, thus are the vital elements in the field of epitope-based vaccine design, antibody production and therapeutic development. However, the experimental approaches in mapping epitopes are time consuming and costly. Computational prediction could offer an unbiased preliminary selection to reduce the number of epitopes for experimental validation. The deposited B-cell epitopes in the databases are those with experimentally determined positive/negative peptides and some are

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Дисертації з теми "Epitope"

1

Lomas, Adrian John. "Poliovirus T cell epitope chimaeras." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318621.

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2

Perikala, Satish Kumar. "Evolution of Epitope regions in HIV genome: Delineating Selective Forces acting on Conformational and Linear Epitopes." [Kent, Ohio] : Kent State University, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1270735952.

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Thesis (M.S.)--Kent State University, 2010.<br>Title from PDF t.p. (viewed Apr. 28, 2010). Advisor: Helen Piontkivska. Keywords: Conformational Epitopes; Linear Epitopes; HIV; Selective Forces; synonymous changes; nonsynonymous changes; Radical changes; Conservative changes. Includes bibliographical references (p. 81-96).

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3

Ruppert, Jörg. "Epitope-Tagging des humanen TSH-Rezeptors." [S.l.] : [s.n.], 2000. http://www.sub.uni-hamburg.de/disse/223/Disse.pdf.

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4

Elmgren, Lindsay Dorn. "Epitope mapping of lyssavirus structural proteins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0014/NQ38783.pdf.

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5

Short, Andrew Keith. "Epitope mapping studies in systemic vaculitis." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338103.

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6

Zhu, Yunyi. "Epitope Mapping using Local Alignment Features." Thesis, KTH, Numerisk analys, NA, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-170658.

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Анотація:

Our immune system uses antibodies to neutralize pathogens such as bacteria and viruses. Antibodies bind to parts of foreign proteins with high efficiency and specificity. We call such parts epitopes. The identification of epitopes, namely epitope mapping, may contribute to various immunological applications such as vaccine design, antibody production and immunological diagnosis. Therefore, a fast and reliable method that can predict epitopes from the whole proteome is highly desirable. In this work we have developed a computational method that predicts epitopes based on sequence information.

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7

Marsh, Steven George Edward. "Epitope mapping in major histocompatibility systems." Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361587.

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8

Sheth-Ughade, Parita. "Immunological responses to fungal epitope peptides." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/immunological-responses-to-fungal-epitope-peptides(1f8234cb-77e4-4577-a6ba-e57d502048a4).html.

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Introduction: Fungi are common aeroallergens responsible for at least 3% – 10% of allergic diseases worldwide, with the proportion hugely variable in different populations. Treatment is complicated by viable nature and disease causing ability of the allergen and is often only palliative. Thus, this study aimed to serve as a pilot investigation to design novel anti-allergy therapeutics to cure allergy at the molecular level. It investigates the effect of wild type fungal peptides and corresponding variant peptides on allergy associated immunological responses – cellular and cytokine based – to

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9

EL-Manzalawy, Yasser. "Machine learning approaches for epitope prediction." [Ames, Iowa : Iowa State University], 2008.

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10

Forner, Mar 1980. "Multi-epitope peptide platforms for vaccine applications." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671028.

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Vaccination constitutes one of the most efficient and cost-effective methods of promoting global health. Nevertheless, few vaccines are fully effective, for manifold reasons ranging from intrinsic limitations to more contingent shortcomings related, e.g., to cold chain transport, handling and storage. In this context, peptide-based vaccines that consist of a fully synthetic approach mimicking B-and T-cell epitopes have emerged as an attractive alternative to overcome many such issues. Unfortunately, short peptides have generally been related to low immunogenicity and weak protection. In this t

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Книги з теми "Epitope"

1

Ulrich, Reineke, and Schutkowski Mike, eds. Epitope mapping protocols. 2nd ed. Humana Press, 2009.

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Ulrich, Reineke, and Schutkowski Mike, eds. Epitope mapping protocols. 2nd ed. Humana Press, 2009.

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3

E, Morris Glenn, ed. Epitope mapping protocols. Humana Press, 1996.

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4

Morris, Glenn E. Epitope Mapping Protocols. Humana Press, 1996. http://dx.doi.org/10.1385/0896033759.

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Schutkowski, Mike, and Ulrich Reineke, eds. Epitope Mapping Protocols. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-450-6.

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6

Rockberg, Johan, and Johan Nilvebrant, eds. Epitope Mapping Protocols. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7841-0.

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7

Rockberg, Johan, Johan Nilvebrant, Magdalena Malm, and Niklas Berndt Thalén, eds. Epitope Mapping Protocols. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4591-8.

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8

M, Eibl Martha, and Mayr W. R. 1944-, eds. Epitope recognition since Landsteiner's discovery: 100 years since the discovery of human blood groups. Springer, 2002.

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9

Al-Dughaym, Abdullah Mohammed. Epitope-mapping immunodominant antigens. University of Manchester, 1995.

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10

Eibl, Martha, W. R. Mayr, and G. J. Thorbecke, eds. Epitope Recognition Since Landsteiner’s Discovery. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-56340-9.

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Частини книг з теми "Epitope"

1

Dragun, Anthony E., Paul J. Schilling, Tod W. Speer, et al. "Epitope." In Encyclopedia of Radiation Oncology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_674.

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2

Lefranc, Marie-Paule. "Epitope." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_663.

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3

Gooch, Jan W. "Epitope." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13690.

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4

Bedinger, Daniel, Judicael Parisot, and Noah T. Ditto. "Competitive Epitope Binning Using HT-SPR." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4591-8_19.

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Abstract Competitive epitope binning using high-throughput surface plasmon resonance (HT-SPR) is a method for understanding competitive epitope profiles of up to hundreds of monoclonal antibodies. Detailed here is an approach along with considerations for the design and analysis of a classical competitive epitope binning assay using the Carterra LSA. Monoclonal antibodies are arrayed on a biosensor chip and interrogated serially for their ability to form a trimolecular complex with antigen and solution phase monoclonal antibodies. Software tools allow the clustering of monoclonal antibodies sh

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5

Morris, Glenn E. "Epitope Mapping." In Springer Protocols Handbooks. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-375-6_38.

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Morris, Glenn E. "Epitope Mapping." In Springer Protocols Handbooks. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-59259-642-3_47.

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7

Morris, Glenn E. "Epitope Mapping." In Immunochemical Protocols. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-59259-257-9_16.

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8

Ranganathan, Shoba. "PMHC Epitope." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_915.

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9

Srinivasan, Ramachandran. "Linear Epitope." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_952.

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10

Srinivasan, Ramachandran. "Discontinuous Epitope." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_962.

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Тези доповідей конференцій з теми "Epitope"

1

Jung, Kathryn. "Artificial Intelligence Approach for Predicting Class I Major Histocompatibility Complex Epitope Presentation and Neo-Epitope Immunogenicity." In 2024 IEEE Integrated STEM Education Conference (ISEC). IEEE, 2024. http://dx.doi.org/10.1109/isec61299.2024.10664816.

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2

Karthiga, M., V. B. Shiv Navin, R. M. Cibin Kumar, B. Sathiya, A. Satheesh Kumar, and M. A. Priyanga. "EnsemBEP: A Robust Ensemble Model for Enhanced B-cell Epitope Prediction." In 2024 8th International Conference on Electronics, Communication and Aerospace Technology (ICECA). IEEE, 2024. https://doi.org/10.1109/iceca63461.2024.10800754.

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Li, Jiarui, Samuel J. Landry, and Ramgopal R. Mettu. "GPU Acceleration of Conformational Stability Computation for CD4+ T-cell Epitope Prediction." In 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2024. https://doi.org/10.1109/bibm62325.2024.10821831.

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4

Nafa, Fatema, and Ryan Kanoff. "Machine Learning based to Predict B-Cell Epitope Region Utilizing Protein Features." In 8th International Conference on Artificial Intelligence and Applications (AI 2022). Academy and Industry Research Collaboration Center (AIRCC), 2022. http://dx.doi.org/10.5121/csit.2022.121811.

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Анотація:

Considering the current state of Covid-19 pandemic, vaccine research and production is more important than ever. Antibodies recognize epitopes, which are immunogenic regions of antigen, in a very specific manner, to trigger an immune response. It is extremely difficult to predict such locations, yet they have substantial implications for complex humoral immunogenicity pathways. This paper presents a machine learning epitope prediction model. The research creates several models to test the accuracy of B-cell epitope prediction based solely on protein features. The goal is to establish a quantit

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5

Wright, D., D. Cliffel, and A. Gerdon. "Nanocluster epitope presentation." In 2006 Bio Micro and Nanosystems Conference. IEEE, 2006. http://dx.doi.org/10.1109/bmn.2006.330893.

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6

Wang, Zhiwei, Yongkang Wang, and Wen Zhang. "Improving Paratope and Epitope Prediction by Multi-Modal Contrastive Learning and Interaction Informativeness Estimation." In Thirty-Third International Joint Conference on Artificial Intelligence {IJCAI-24}. International Joint Conferences on Artificial Intelligence Organization, 2024. http://dx.doi.org/10.24963/ijcai.2024/669.

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Accurately predicting antibody-antigen binding residues, i.e., paratopes and epitopes, is crucial in antibody design. However, existing methods solely focus on uni-modal data (either sequence or structure), disregarding the complementary information present in multi-modal data, and most methods predict paratopes and epitopes separately, overlooking their specific spatial interactions. In this paper, we propose a novel Multi-modal contrastive learning and Interaction informativeness estimation-based method for Paratope and Epitope prediction, named MIPE, by using both sequence and structure dat

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7

Solihah, Binti, Edi Winarko, Afiahayati, Sri Hartati, and Moh Edi Wibowo. "A systematic review: B-cell conformational epitope prediction from epitope characteristics view." In 2017 3rd International Conference on Science and Technology - Computer(ICST). IEEE, 2017. http://dx.doi.org/10.1109/icstc.2017.8011859.

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8

Cierniewski, C. S., та A. Z. Budzynski. "CONFORMATIONAL EQUILIBRIA IN THE γ CHAIN COOH-TERMINUS OF HUMAN FIBRINOGEN". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642935.

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Synthetic peptides and fragments cleaved from native fibrinogen are used in studies to localize binding sites for various ligands. We addressed the question how the native conformation of a selected γ chain segment is affected by scission of the original chain. The conformation of the γ chain COOH-terminus of intact fibrinogen and its various fragments containing this region has been compared by an immunochemical analysis. An antibody population specific for the native epitope within the γ391-405 segment was isolated by affinity chromatography on the corresponding synthetic peptide. Between 19

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Chumak, N. S., and Y. I. Melnikova. "OBTAINING AND IMMUNOCHEMICAL TESTING OF APOFERRITIN." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-1-289-293.

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The process of direct binding of monoclonal antibodies to apoferritin immobilized on polystyrene, as well as the method of competitive interaction of monoclonal antibodies with apoferritin in solution, have been experimentally studied. It was found that the immobilization of apoferritin on a polystyrene surface leads to a change in the epitope structure of this protein and to the elimination of reactive epitopes of binding of monoclonal antibodies. The soluble form of apoferritin effectively binds to monoclonal antibodies in a competitive assay, which confirms the conformational nature of the

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Lo, Ying Tsang, Tun Wen Pai, Hui Huang Hsu, and Huai Kuang Tsai. "Epitope and Paratope Region Analysis." In 2014 Eighth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS). IEEE, 2014. http://dx.doi.org/10.1109/cisis.2014.73.

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Звіти організацій з теми "Epitope"

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Gershoni, Jonathan M., David E. Swayne, Tal Pupko, et al. Discovery and reconstitution of cross-reactive vaccine targets for H5 and H9 avian influenza. United States Department of Agriculture, 2015. http://dx.doi.org/10.32747/2015.7699854.bard.

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Research objectives: Identification of highly conserved B-cell epitopes common to either H5 or H9 subtypes of AI Reconstruction of conserved epitopes from (1) as recombinantimmunogens, and testing their suitability to be used as universal vaccine components by measuring their binding to Influenza vaccinated sera of birds Vaccination of chickens with reconstituted epitopes and evaluation of successful vaccination, clinical protection and viral replication Development of a platform to investigate the dynamics of immune response towards infection or an epitope based vaccine Estimate our ability t

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Hunt, Donald F. Neurotoxin and Epitope Structural Studies. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada233710.

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นิลอุบล, เดชฤทธิ์, อังคณา ตันติธุวานนท์, ธิติมา ไตรพิพัฒน์ та อรรถพล มาดาป้อง. การทดสอบประสิทธิภาพของดีเอ็นเอวัคซีนในภาคสนามเพื่อควบคุมโรคพีอาร์อาร์เอส : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.67.

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การดำเนินงานวิจัยนี้มีวัตถุประสงค์เพื่อผลิตต้นแบบดีเอ็นเอวัคซีนเพื่อป้องกันโรคติดเชื้อไวรัสพีอาร์อาร์เอส โดยดีเอ็นเอต้นแบบที่ผลิตขึ้นมีส่วนประกอบของยีน ORF5 ของไวรัสพีอาร์อาร์เอสที่มีการแทรกยีน PADRE ระหว่าง decoy epitope และ neutralizing epitope และศึกษาประสิทธิภาพของดีเอ็นเอวัคซีนต้นแบบนั้นในการกระตุ้นสร้าง neutralizing antibody แบ่งการวิจัยออกเป็น 3 ส่วนประกอบด้วย การผลิตดีเอ็นเอวัคซีน การทดสอบขนาดที่ใช้และการทดสอบประสิทธิภาพการกระตุ้นภูมิคุ้มทั้งโดยวัดจาก serum neutralization และ lymphocyte proliferative assays ในภาคสนาม ผลการทดลองพบว่าดีเอ็นเอวัคซีนที่พัฒนาขึ้นสามารถกระตุ้นสร้างแอนติบอดีแ

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Ioannides, Constantin G. Epitope Specific T Cell Immunity to Breast Cancer. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada414361.

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Ioannides, Constantin. Epitope Specific T Cell Immunity to Breast Cancer. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada392776.

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6

Ioannides, Constantin G. Epitope Specific T-Cell Immunity to Breast Cancer. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada381286.

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Moores, Lee C., P. U. Ashvin, I. Fernando, and Garret W. George. Synthesis of 2-Methoxypropyl Benzene for Epitope Imprinting. U.S. Army Engineer Research and Development Center, 2022. http://dx.doi.org/10.21079/11681/44883.

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Harmful algal blooms (HABs) are occurring with increasing frequency and severity across the globe in part due to climate change and anthropogenic pollution (Bullerjahn et al. 2016). HABs produce several classes of toxins; however, microcystins (MCs) are the most commonly studied (Lone et al. 2015) and can be potent toxins with LD50s in the range of 50 μg/kg (Puddick et al. 2014). Sample analysis in laboratories, typically by high-pressure liquid chromatography tandem mass spectrometry (HPLC-MS/MS) or by Enzyme Linked Immunosorbent Assays (ELISAs) (USEPA 2015). These analytical techniques are h

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Lopez Bautista, Cesar. Large scale MD to predict Epitope regions in HIV Env. Office of Scientific and Technical Information (OSTI), 2022. http://dx.doi.org/10.2172/1841887.

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Kiertscher, Sylvia M. The Advantages of Multi-Epitope Tumor Antigens as an Approach to Treating Breast Cancer. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada398108.

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Sette, Alesandro, Bjoern Peters, and Martin Blythe. Predicting the Interplay of Epitope Recognition and Evolution in RNA Viruses Under Immune Pressure. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada500852.

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