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Дисертації з теми "Epitope"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Lomas, Adrian John. "Poliovirus T cell epitope chimaeras." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318621.

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2

Perikala, Satish Kumar. "Evolution of Epitope regions in HIV genome: Delineating Selective Forces acting on Conformational and Linear Epitopes." [Kent, Ohio] : Kent State University, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1270735952.

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Thesis (M.S.)--Kent State University, 2010.<br>Title from PDF t.p. (viewed Apr. 28, 2010). Advisor: Helen Piontkivska. Keywords: Conformational Epitopes; Linear Epitopes; HIV; Selective Forces; synonymous changes; nonsynonymous changes; Radical changes; Conservative changes. Includes bibliographical references (p. 81-96).

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3

Ruppert, Jörg. "Epitope-Tagging des humanen TSH-Rezeptors." [S.l.] : [s.n.], 2000. http://www.sub.uni-hamburg.de/disse/223/Disse.pdf.

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4

Elmgren, Lindsay Dorn. "Epitope mapping of lyssavirus structural proteins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0014/NQ38783.pdf.

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5

Short, Andrew Keith. "Epitope mapping studies in systemic vaculitis." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338103.

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6

Zhu, Yunyi. "Epitope Mapping using Local Alignment Features." Thesis, KTH, Numerisk analys, NA, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-170658.

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Our immune system uses antibodies to neutralize pathogens such as bacteria and viruses. Antibodies bind to parts of foreign proteins with high efficiency and specificity. We call such parts epitopes. The identification of epitopes, namely epitope mapping, may contribute to various immunological applications such as vaccine design, antibody production and immunological diagnosis. Therefore, a fast and reliable method that can predict epitopes from the whole proteome is highly desirable. In this work we have developed a computational method that predicts epitopes based on sequence information.

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7

Marsh, Steven George Edward. "Epitope mapping in major histocompatibility systems." Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361587.

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8

Sheth-Ughade, Parita. "Immunological responses to fungal epitope peptides." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/immunological-responses-to-fungal-epitope-peptides(1f8234cb-77e4-4577-a6ba-e57d502048a4).html.

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Introduction: Fungi are common aeroallergens responsible for at least 3% – 10% of allergic diseases worldwide, with the proportion hugely variable in different populations. Treatment is complicated by viable nature and disease causing ability of the allergen and is often only palliative. Thus, this study aimed to serve as a pilot investigation to design novel anti-allergy therapeutics to cure allergy at the molecular level. It investigates the effect of wild type fungal peptides and corresponding variant peptides on allergy associated immunological responses – cellular and cytokine based – to

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9

EL-Manzalawy, Yasser. "Machine learning approaches for epitope prediction." [Ames, Iowa : Iowa State University], 2008.

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10

Forner, Mar 1980. "Multi-epitope peptide platforms for vaccine applications." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671028.

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Vaccination constitutes one of the most efficient and cost-effective methods of promoting global health. Nevertheless, few vaccines are fully effective, for manifold reasons ranging from intrinsic limitations to more contingent shortcomings related, e.g., to cold chain transport, handling and storage. In this context, peptide-based vaccines that consist of a fully synthetic approach mimicking B-and T-cell epitopes have emerged as an attractive alternative to overcome many such issues. Unfortunately, short peptides have generally been related to low immunogenicity and weak protection. In this t

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11

Ludolfs, Diana. "Charakterisierung typenspezifischer B-Zell-Epitope der Flaviviren." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966135768.

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12

Polyak, Maria J. "Structural analysis and epitope mapping of CD20." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ49652.pdf.

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13

Wightman, Lionel. "Linear epitope tagging of the prion protein." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282977.

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14

Robakiewicz, Stefania. "Minimal structural glyco-epitope for antibody recognition." Thesis, Lille 1, 2020. http://www.theses.fr/2020LIL1S101.

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L'importance biologique de la glycosylation pour la santé et la maladie est largement reconnue. Les structures tronquées à terminaison mannose consistant en 1 à 3 résidus de mannose, deux N-acétylglucosamines et un nombre variable de fragments fucose sont appelées paucimannose. Les N-glycanes paucimannosidiques sont abondamment exprimés dans les plantes et les invertébrés. Cependant, chez les vertébrés, leur présence est limitée à certaines conditions pathophysiologiques, telles que le cancer, les troubles immunitaires, les infections et l'inflammation, et chez les individus en bonne santé, il

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15

Zandian, Arash. "Array-based Autoantibody Profiling and Epitope Mapping." Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-213689.

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Antibodies are a class of proteins that are made by the immune system to recognize harmful organisms and molecules. Their exceptional capability of specifically recognizing molecules has been investigated for over a century and information thereof has been utilized for a variety of applications including vaccine and generation of therapeutic antibodies. Occasionally, instead of protecting the host against pathogens, antibodies can recognize constituents of the host and thereby cause an autoimmune reaction that eventually can lead to a disease. Therefore, it is of great interest to understand w

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16

Lima, Neto Daniel Ferreira 1979. "Efeito da alta pressão hidrostática no mapeamento de epítopos da proteína do capsídeo do vírus do mosaico do tabaco." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316615.

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Orientador: Clarice Weis Arns<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-22T02:52:00Z (GMT). No. of bitstreams: 1 LimaNeto_DanielFerreira_D.pdf: 8189026 bytes, checksum: 64631e8e2ed546b6da6a944505049080 (MD5) Previous issue date: 2012<br>Resumo: O resumo poderá ser visualizado no texto completo da tese digital<br>Abstract: The abstract is available with the full electronic document<br>Doutorado<br>Microbiologia<br>Doutor em Genetica e Biologia Molecular

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17

Hjelm, Barbara. "Epitope mapping of antibodies towards human protein targets." Doctoral thesis, KTH, Proteomik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-59529.

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This thesis, based on five research papers, presents results from development and evaluation ofmethods for identifying the interaction site of antibodies on their antigens and the functional investigation of these in different assays. As antibodies have proven to be invaluable tools in diagnostics, therapy and basic research, the demand of characterizing these binding molecules has increased. Techniques for epitope mapping in a streamlined manner are therefore needed, particularly in high throughput projects as the Human Protein Atlas that aims to systematically generate two antibodies with se

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18

Oak, James N. "Characterization of epitope-tagged dopamine D¦4 receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0001/MQ45554.pdf.

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19

Wong, Mee Ling. "Attempts to construct functional epitope-tagged ACTH receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0006/MQ46149.pdf.

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20

Zuliani, Alvarez Lorena. "Mapping the pro-inflammatory epitope of tenascin-C." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:c13d2dad-4782-4d50-a8b6-95606ddcf785.

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Endogenous molecules, including extracellular matrix (ECM) proteins, have been shown to induce inflammation via toll-like receptor (TLR) activation in order to drive an immune response to tissue damage. Tenascin-C, an ECM glycoprotein transiently induced in injury and persistently expressed during chronic inflammatory diseases, stimulates cytokine synthesis via activation of TLR4 by its C-terminus fibrinogen-like globe (FBG-C) domain. However, the specific epitope of FBG-C that activates TLR4 is not known. Unlike tenascin-C, other tenascin family members (tenascin-R, -W and -X) are constitutiv

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21

Bothamley, Graham Henry. "Analysis of epitope-specific antibody levels in tuberculosis." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/47780.

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22

Serafin, Ina Loretta. "Epitope mapping of the dengue 3 envelope protein." Thesis, Queensland University of Technology, 1999.

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23

Anchim, Aleksandra. "Vaccination Potential Of Adenoviral Vectors Displaying Heterologous Epitopes In Their Capsid Proteins." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS070/document.

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Mes travaux de thèse ont pour but d’évaluer l’approche « épitope display » pour sa capacité d'induire les réponses cellulaires. Ad à capside modifiée par insertion de différents épitopes T issus de la ovalbumine ont étés produit. Après administration à des souris C57BL/6, j'ai mis en évidence l'induction de la réponse cellulaire dirigée contre les épitope insérés (grâce aux techniques ELISPOT, tétramères, ou bien en quantifiant la production d’IFNg par les splénocytes restimulés in vitro). J’ai démontré que ces réponses sont limités chez des souris préalablement immunisées avec Ad. Des manipul

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24

Paul, Sinu. "Host-pathogen interactions and evolution of epitopes in HIV-1: understanding selection and escape." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1334509644.

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25

Scott, Alison. "Epitope tagging of the human hâ†1 histamine receptor." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341971.

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26

Newcombe, Jane E. "Expression and epitope of the rubella virus E1 glycoprotein." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359665.

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27

Wilde, Andrew Rhys. "Epitope mapping and structural studies on TGN 38/41." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386177.

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28

Behr, Jonathan Robert. "Novel tools for sequence and epitope analysis of glycosaminoglycans." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42383.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.<br>Includes bibliographical references.<br>Our understanding of glycosaminoglycan (GAG) biology has been limited by a lack of sensitive and efficient analytical tools designed to deal with these complex molecules. GAGs are heterogeneous and often sulfated linear polys accharides found throughout the extracellular environment, and available to researchers only in limited mixtures. A series of sensitive label-free analytical tools were developed to provide sequence information and to quantify whole epi

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29

Heslop, Ian. "Synthetic approaches to discontinuous epitope mapping of HIV-I." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/14061.

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The synthesis of IH1, a peptide designed to mimic a discontinuous epitope on HIV-I gp120, is reported. The aspartimide rearrangement inherent in this sequence, and in the peptide GC1, has been studied and reduced to low levels. The syntheses of variants of peptide GC1, containing differing number of residues found to be important for CD4 binding, have also been achieved. Thus peptides containing one, two, three and four residues necessary for high affinity binding have been synthesised. In addition a peptide has been synthesised which incorporates a synthetic β turn moiety other than the Cys-V

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30

Longepe, Jacques. "Structure et synthese d'un epitope isole de mycobacterium gastri." Orléans, 1996. http://www.theses.fr/1996ORLE2040.

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Nous avons determine la stereostructure relative d'un nouveau 3,6-didesoxy-4-c-(1,3-dimethoxy-4,5,6,7-tetrahydroxyheptyl)-alpha xylo-hexopyranoside, epitope d'un lipooligosaccharide antigenique isole de mycobacterium gastri. Pour ce faire, la synthese de differents diastereoisomeres de ce sucre branche en c-4 a ete realisee a partir du d-glucose et du lyxose dans les series d et l afin de comparer les donnees de spectroscopie rmn des produits de synthese et du produit naturel peracetyles. Nous avons mis au point une methode generale de preparation des sucres branches possedant la fonctionnalit

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31

Tahir, Shifa. "A docking-based method for in silico epitope determination." Thesis, Tours, 2018. http://www.theses.fr/2018TOUR4008.

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Le développement des anticorps thérapeutiques s'est rapidement accéléré dans les 10 dernières années et concerne un nombre croissant de pathologies. La connaissance de l'épitope, à savoir la région de la cible à laquelle l'anticorps se fixe, est essentielle pour la compréhension des effets fonctionnels de ce dernier. Nous avons développé une méthode in silico, MAbTope, qui permet une prédiction précise de cet épitope, quand bien même aucune structure 3D de l'anticorps d’intérêt n'est résolue. Cette méthode se base sur une méthode d'amarrage protéine-protéine développée auparavant dans l’équipe

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32

SHREYA. "PREDICTION OF EPITOPE BASED VACCINE CANDIDATES FOR PERIODONTAL DISEASE." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18421.

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Periodontal disease is a multifactorial dental complication that has an impact on the supporting tooth structures like the gingiva, cementum and alveolar bone. Various studies conclude PD is associated with several systemic diseases like cardiovascular, neuronal, autoimmune, and respiratory. It is seen that periodontal disease is also allied with PCOS, infertility, age, obesity, adverse pregnancy outcomes, erectile dysfunction, and diabetes. The individuals suffering from PD are more likely to have dental caries. The initiation is due to dysbiosis of commensal microbes present in the ora

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33

Wang, Zilong. "Expression of epitope-tagged protein kinase CK2 in mammalian cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ32281.pdf.

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34

Garrett, Joan Teresa. "Peptide-based B-cell epitope vaccines targeting HER-2/neu." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189103626.

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35

Stephens, D. Michael. "Epitope mapping of antibodies to the envelope proteins of HIV." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239815.

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36

Palmowski, Michael J. "Strategies for the induction of epitope-specific polyvalent CTL responses." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249165.

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37

Nguyen, Brenda. "Expression of an epitope tagged tarp effector in chlamydia trachomatis." Honors in the Major Thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/890.

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Previous studies performed on Chlamydia trachomatis have demonstrated how these obligate intracellular microbes invade host cells through the utilization of secreted effector proteins. One secreted effector called Tarp (translocated actin recruiting protein) is implicated in cytoskeleton rearrangements that promote bacterial entry into the host cell. The focus of our study is to create a plasmid that carries the tarP gene that when transcribed and translated from within Chlamydia trachomatis will generate a c-Myc epitope tagged Tarp. The tag will be used in future studies to track the progress

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38

Smith, Richard Gary. "The regulation of peptide mimotope/epitope recognition by monoclonal antibodies." Thesis, University of Nottingham, 2002. http://eprints.nottingham.ac.uk/10053/.

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Protein-based therapeutics play an increasingly important role in medicine, and the exquisite bio-recognition properties exhibited by antibodies has also led the their use in a number of other fields apart from medicine. The increasing use of these molecules requires more efficient methods of purification. A review of the current purification strategies was conducted. Of all the purification methods studied, peptide epitope/mimotope affinity chromatography proved to be the method of choice - resulting in antibodies exhibiting high specific immunoreactivity. The need to tailor unique affinity l

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39

McCormick, David. "Characterisation of and cellular responses to the P91A tum'- epitope." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286334.

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40

Borley, Daryl W. "Epitope dominance studies with serotype O foot-and-mouth disease." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:4adc3373-1d89-41d9-b1ce-7d8cbb0e817a.

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Foot-and-mouth disease virus (FMDV) is an economically devastating and highly contagious livestock pathogen. It exists as seven serotypes, comprising numerous antigenically distinct subtypes. The large amount of antigenic heterogeneity has confounded attempts at developing broadly reactive vaccines. In order to overcome this issue the fundamentals of the interactions between the virus and the host humoral immune response must first be understood. Previous work in this area using monoclonal antibody (mAb) escape mutants has identified five antigenic sites for the O serotype and efforts have bee

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41

Garrett, Joan T. "Peptide-based B-cell epitope vaccines targeting HER-2/neu." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1189103626.

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42

Da, Silva Pissarra Joana. "Development of a multi-epitope peptide vaccine against human leishmaniases." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT013/document.

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La leishmaniose est une maladie tropicale négligée à transmission vectorielle qui est endémique dans 98 pays dont les plus pauvres. Vingt espèces de Leishmania sont capables d’établir une infection intracellulaire au sein des macrophages humains, provoquant différentes manifestations cliniques. Le développement d'un vaccin contre les leishmanioses est étayé par des preuves d'immunité naturelle contre l'infection, induite par une réponse à médiation cellulaire de type Th1 dominante associée à la production d'IFN-γ, d'IL-2 et de TNF-α par des cellules T polyfonctionnelles TCD4+ et TCD8+, conduis

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43

Davenport, Claire. "Autoantibodies as pathogenetic markers in insulin-dependent diabetes and related disorders." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295768.

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44

Sturniolo, Tiziana Concetta. "Systematic characterisation of HLA Class II ligand binding specificity by quantitative matrices." Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264399.

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45

Schöne, Dominik [Verfasser], and Ulf [Akademischer Betreuer] Dittmer. "Identifikation von CD8+ T-Zell Epitopen in adenoviralen Kapsid-Proteinen und Analyse von Immundominanz-Hierarchien adenoviraler Epitope gegenüber Transgen-Epitopen bei Immunisierung mit adenoviralen Vektoren / Dominik Schöne ; Betreuer: Ulf Dittmer." Duisburg, 2019. http://d-nb.info/1191692299/34.

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46

Parthasarathy, Upasana. "Identifying epitopes of anti-FcaRI monoclonal antibodies on FcaRI ectodomain that trigger the anti-inflammatory ITAMi signaling pathway." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1418910350.

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47

Wang, Min-Guang Cheung H. Tak. "Identification of an extracellular matrix epitope involved in T cell adhesion." Normal, Ill. Illinois State University, 1992. http://wwwlib.umi.com/cr/ilstu/fullcit?p9311292.

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Thesis (Ph. D.)--Illinois State University, 1992.<br>Title from title page screen, viewed February 7, 2006. Dissertation Committee: H. Tak Cheung (chair), Mathew J. Nadakavukaren, Alan J. Katz, Brian J. Wilkinson, Lynne A. Lucher. Includes bibliographical references (leaves 103-114) and abstract. Also available in print.

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48

Getahun, Andrew. "Antibody Feedback Regulation : From Epitope Masking to T Helper Cell Activation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4580.

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49

Angove, Helen Louise. "The identification of bluetongue virus T-cell epitope(s) in sheep." Thesis, University of Hertfordshire, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260772.

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BENAZET, JEAN-FRANCOIS. "Polyarthrite rhumatoide et epitope partage : a propos de 53 cas marseillais." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20852.

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