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Дисертації з теми "Estrogen Therapeutic use"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 31 січня 2023

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1

Jetson, Rachael Rene. "Design and Development of Potential Therapeutic Agents for Use in Hormone Responsive Cancers." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384270219.

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2

Dennis, Maxine Elizabeth. "Oestrogen and atherosclerosis." University of Western Australia. School of Pathology and Laboratory Medicine, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0134.

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[Truncated abstract] Our understanding of the actions of oestrogen on the vasculature has recently been questioned following the results of large clinical trials revealing a negative effect of hormone replacement therapy (HRT) on cardiovascular disease (CVD) risk amongst postmenopausal women. It is important to determine how a hormone with numerous positive effects on intermediate pathways of atherosclerosis fails to offer cardioprotection. Further investigation into the actions of oestrogen in the vasculature may add to our current understanding of the pathogenesis of atherosclerosis and oest

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3

Benz, David James. "Estrogenic and androgenic regulation of human osteoblast-like cells is mediated by specific steroid receptors." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185442.

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The effectiveness of estrogen replacement therapy in the prevention of postmenopausal osteoporosis has led to its current widespread use throughout the United States and much of Western Europe, and recently, clinical correlations between circulating androgen levels and structural bone integrity have been presented. Nevertheless, the biochemical mechanism through which estrogens and androgens act to protect and maintain bone has remained unclear. One possibility is that these hormones directly modulate the activity of cells responsible for bone formation. Therefore, studies were conducted to ex

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4

Amaral, Sandra Margarida Caldas. "Estrogen receptor dependent genetic and epigenetic factors of tamoxifen resistance." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2009. http://hdl.handle.net/10362/5038.

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Resumo: A decisão da terapêutica hormonal no tratamento do cancro da mama baseiase na determinação do receptor de estrogénio alfa por imunohistoquímica (IHC). Contudo, a presença deste receptor não prediz a resposta em todas as situações, em parte devido a limitações do método IHC. Investigámos se a expressão dos genes ESR1 e ESR2, bem como a metilação dos respectivos promotores, pode estar relacionada com a evolução desfavorável de uma proporção de doentes tratados com tamoxifeno assim como com a perda dos receptores de estrogénio alfa (ERα) e beta (ERß). Amostras de 211 doentes com cancro

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5

Papich, Sandra G. (Sandra Gene). "Estrogen Replacement Therapy and its Association with Life Satisfaction of Women over Fifty." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc500948/.

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This study analyzed the effects of estrogen replacement therapy (ERT), ethnicity, marital status, education level, maternal status and financial security on the perceived life satisfaction of women over fifty. Information was collected from 125 subjects at an independent school district. The instrument was adapted from a life satisfaction scale originally developed by B. Neugarten. Eight demographic items included ERT use, age, menopause status, marital status, educational level, ethnicity and perception of financial security. Statistical analysis consisting of one way analysis of variance, St

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6

Hatchell, Esme Claire. "Insight into estrogen action in breast cancer via the study of a novel nuclear receptor corepressor : SLIRP." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0206.

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[Truncated abstract] Breast cancer is the cause of significant suffering and death in our community. It is now estimated that the risk of developing breast cancer for an Australian woman before the age of 85 is 1 in 8, with this risk rising for unknown reasons. While mortality rates from breast cancer are falling due to increased awareness and early detection, few new treatments have been developed from an advanced understanding of the molecular basis of the disease. From decades of scientific research it is clear that estrogen (E2) has a large role to play in breast cancer. However, the basic

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7

Visser, Jacobus Albertus Koch. "Phytoestrogenic extracts of Cyclopia modulate molecular targets involved in the prevention and treatment of breast cancer." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86718.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Phytoestrogen containing extracts of Cyclopia, an indigenous South African fynbos plant used to prepare honeybush tea, may serve as a source of new estrogen analogues. It would be of great benefit if these new analogues would not only prevent the development and progression of breast cancer which, globally, is responsible for the highest number of cancer associated deaths among females, but also have a reduced side-effect profile when compared to current treatments and, in addition, also alleviate menopause associated symptoms.

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8

Wu, Wing Man. "An investigation into the neuroprotective effects of estrogen and progesterone in a model of homocysteine-induced neurodegeration." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003284.

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Homocysteine (Hcy) is a sulfur containing amino acid and is a potent neurotoxin. It has been shown that elevated levels of Hcy, termed hyperhomocysteinemia, plays a role in the pathologies of Alzheimer’s disease (AD) and age-related cognitive decline. Hcy is a glutamate agonist, which causes in increase in Ca[superscript (2+)] influx via the activation of NMDA class of excitatory amino acid receptors, which results in neuronal cell death and apoptosis. Estrogen and progesterone are female hormones that are responsible for reproduction and maternal behaviour. However, in the last decade, it is

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9

Kampen, Diane L. "The relationship between estrogen and memory in healthy postmenopausal women and women in the early stages of Alzheimer's disease." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41108.

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The effects of exogenous estrogen administration on aspects of memory and cognition in women were examined in two studies. In Study 1, women receiving estrogen replacement therapy were compared to untreated women on four measures of verbal memory. Those receiving estrogen had significantly better scores on a measure of delayed memory for propositional material. In Study 2, women in the early stages of Alzheimer's Disease (AD) were administered either estrogen or placebo on a double-blind basis for six months. Women given estrogen showed improvement on a measure of verbal memory and spatial att

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10

Phillips, Susana M. (Susana Maria). "The relationship between sex steroid levels and memory functions in women." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28513.

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Memory function was examined in association with sex hormone levels in women. The results of the first study suggest that self-reports of memory problems were especially prevalent among women attending a menopause clinic compared to a nonpatient sample. In the following investigation, women given placebo after undergoing a bilateral oophorectomy showed decreases in memory performance, specifically on a paired-associate learning task, coincident with declines in estrogen levels. Significant improvements were found in estrogen-treated women pre- to postoperatively in the immediate recall of para

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11

Murtagh, Madeleine Josephine. "Intersections of feminist and medical constructions of menopause in primary medical care and mass media: risk, choice and agency." Title page, table of contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phm9851.pdf.

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Includes bibliographical references (leaves 254-288). Examines language used by general practitioners and in mass media to ask 'what are the implications of constructions of menopause for health care practice and public health for women at menopause?'. Presents the findings of qualitative analysis of semi-structured interviews with nine general practitioners working in rural South Australia and qualitative and quantitative analyses of 345 south Australian newspaper articles from 1986 to 1998.

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12

Penteado, Sônia Regina Lenharo. "Terapia hormonal e sexualidade em mulheres na pós-menopausa." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-15102014-093313/.

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OBJETIVOS. Verificar os efeitos da terapia hormonal com derivados estrogênicos e progestogênicos, isolados ou associados à metiltestosterona, na sexualidade e nos sintomas climatéricos em mulheres na pós-menopausa e comparar os dois tipos de terapia hormonal. CASUÍSTICA. Selecionaram-se sessenta mulheres sexualmente ativas, com queixas sexuais, com relacionamento estável com parceiro capacitado para o coito, com idade de 42 a sessenta anos (média etária 52,1 + 4 anos) e tempo de menopausa de um a 28 anos (média 5,6 anos). Excluíram-se mulheres com doenças sistêmicas, doenças psiquiátricas, end

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13

"The effect of hormone replacement therapy on lipoprotein (a) and other atherogenic lipids and lipoproteins in postmenopausal Chinese women." Chinese University of Hong Kong, 1996. http://library.cuhk.edu.hk/record=b5888772.

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Christopher John Haines.<br>Thesis (M.D.)--Chinese University of Hong Kong, 1996.<br>Includes bibliographical references (leaves 239-279).<br>LIST OF TABLES --- p.xviii<br>LIST OF FIGURES --- p.xxi<br>LIST OF ABBREVIATIONS --- p.xxii<br>Chapter CHAPTER1 --- INTRODUCTION --- p.1<br>Problems related to the menopause<br>Research plan<br>Chapter CHAPTER2 --- OVERVIEW --- p.15<br>Introduction<br>Atherosclerosis and the lipid profile<br>Coronary artery disease and lipid abnormalities in women<br>"Exogenous oestrogens, progestogens and coronary artery disease "<br>Lipoprotein (a)<br>Chapter CHAP

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14

"Modification of anticancer drug sensitivity of human prostate cancer cells by estrogen related compounds." 1998. http://library.cuhk.edu.hk/record=b5889640.

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by Cheung Tak Chi.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1998.<br>Includes bibliographical references (leaves 117-123).<br>Abstract also in Chinese.<br>Acknowledgeements --- p.i<br>Abbreviations --- p.ii<br>Abstract --- p.v<br>List of Figures --- p.viii<br>List of Tables --- p.xiv<br>Contents --- p.xv<br>Contents<br>Chapter 1. --- Introduction --- p.1<br>Chapter 1.1 --- Epidemiological Risk Factors --- p.1<br>Chapter 1.1.1 --- Age --- p.1<br>Chapter 1.1.2 --- Race --- p.2<br>Chapter 1.1.3 --- Environmental or Migratory Factor --- p.2<br>Chapter 1.1.4 --- Diet --- p.

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15

"Effect of phytochemicals on estrogen biosynthesis in human breast cancer and placental cells." Thesis, 2005. http://library.cuhk.edu.hk/record=b6074044.

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A breast cancer cell line stably transfected with the CYP19 gene had been employed for aromatase inhibition. Among the phytochemicals tested, the major dietary flavonoids, such as genistein and daidzein, produced very weak inhibition. On the other hand, the red clover isoflavone biochanin A, the hydroxychalcone butein and the red grape phytoalexin resveratrol were found to be effective aromatase inhibitors. Cell proliferation assay had shown that they could inhibit ER-positive cell proliferation induced by testosterone, and the inhibitory effect was specifically attributed to the reduction of

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16

"Selective estrogen receptor modulators, nitric oxide and vascular reactivity." 2004. http://library.cuhk.edu.hk/record=b6073649.

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Wong Chi Ming.<br>"August 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 182-215).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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17

Harris, Janet Elizabeth. "The effect of estrogen replacement therapy on vitamin B-6 status of postmenopausal women." Thesis, 1990. http://hdl.handle.net/1957/27135.

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This investigation was conducted to determine the effect of estrogen replacement therapy (ERT) on vitamin B-6 status of postmenopausal women. Nineteen postmenopausal women served as subjects. Nine (54.7 + 4.7 years) were taking ERT (experimental group); ten (56.8 + 2.3 years) were not (control group). For three consecutive days, subjects recorded their dietary intake and collected their 24-hour urine specimens. On the fourth day, a fasting blood sample was drawn from the subjects. The dietary intake of vitamin B-6, as well as the concentration of total vitamin B-6 in plasma (PB6; and urine (UB

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18

"The anti-tumor effects of arsenic trioxide on human breast adenocarcinoma cell line, MCF-7." 2002. http://library.cuhk.edu.hk/record=b5891310.

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by Chow Ka Yee.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2002.<br>Includes bibliographical references (leaves 203-221).<br>Abstracts in English and Chinese.<br>Acknowledgements --- p.i<br>Abstract --- p.ii<br>Abstract in Chinese --- p.iv<br>List of Abbreviations --- p.vi<br>Table of Contents --- p.xi<br>List of Figures --- p.xviii<br>List of Tables --- p.xxii<br>Chapter CHAPTER 1 --- INTRODUCTION --- p.1<br>Chapter 1.1 --- The Characteristics of Arsenic Trioxide (AS2O3) --- p.2<br>Chapter 1.2 --- The Therapeutic Applications of Arsenic Trioxide (As203) --- p.5<br>Chapter

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19

"Modulation of vascular reactivity by selective estrogen receptor modulators and dihydropyridines in porcine coronary arteries." 2005. http://library.cuhk.edu.hk/record=b5892728.

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Leung Hok Sum.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 128-147).<br>Abstracts in English and Chinese.<br>Declaration --- p.i<br>Acknowledgements --- p.ii<br>Abbreviation --- p.iii<br>Abstract in English --- p.iv<br>Abstract in Chinese --- p.vi<br>Contents --- p.viii<br>Chapter Chapter I - --- Introduction<br>Chapter 1.1. --- Steroid Hormone --- p.1<br>Chapter 1.2. --- Estrogen Receptors --- p.2<br>Chapter 1.3. --- Selective Estrogen Receptor Modulators --- p.5<br>Chapter 1.3.1. --- Tamoxifen --- p.5<br>Chapter 1.3.1.1

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20

"Effect of phytoestrogens on low-density- lipoprotein receptor and apolipoprotein A-I expression in HepG2 cells." 2005. http://library.cuhk.edu.hk/record=b5896408.

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Yuen Yee Man.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 108-125).<br>Abstracts in English and Chinese.<br>TITLE PAGE --- p.1<br>ACKNOWLEGDEMENTS --- p.2<br>ABSTRACT --- p.3<br>摘要 --- p.5<br>table of contents --- p.7<br>list of figures and tables --- p.13<br>CHAPTER 1 GENERAL INTRODUCTION --- p.16<br>Chapter 1.1 --- role of PHYTOESTROGENS in soy and red WINE the PREVENTION OF CARDIOVASCULAR DISEASES (CVD) --- p.17<br>Chapter 1.1.1 --- INTRoduction and Classification of Phytoestrogens --- p.17<br>Chapter 1.1.2 --- estrogen

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21

"Flavonoids display differential actions on er transactivation and apoptosis in MCF-7 cells." 2002. http://library.cuhk.edu.hk/record=b5896009.

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Po Lai See.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2002.<br>Includes bibliographical references (leaves 142-152).<br>Abstracts in English and Chinese.<br>TITLE PAGE --- p.p.1<br>ACKNOWLEGDEMENTS --- p.p.2<br>ABSTRACT --- p.p.3<br>摘要 --- p.p.6<br>TABLE OF CONTENTS --- p.p.9<br>LIST OF FIGURES AND TABLES --- p.p.16<br>Chapter CHAPTER 1 --- GENERAL INTRODUCTION<br>Chapter 1.1 --- Estrogen and Estrogen Receptors and its Action --- p.p.18<br>Chapter 1.1.1 --- Estrogen --- p.p.19<br>Chapter 1.1.2 --- Estrogen Receptors --- p.p.19<br>Chapter 1.1.3 --- Structural Diff

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22

Robarge, Jason Dennis. "Aromatase inhibitors produce hypersensitivity in experimental models of pain : studies in vivo and in isolated sensory neurons." Thesis, 2014. http://hdl.handle.net/1805/6056.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Aromatase inhibitors (AIs) are the current standard of care for the treatment of hormone receptor positive breast cancer in postmenopausal women. Nearly one-half of patients receiving AI therapy develop musculoskeletal toxicity that is characterized by joint and/or muscle pain and approximately one-fourth of patients discontinue their therapy as a result of musculoskeletal pain. Since there are no effective strategies for prevention or treatment, insight into the mechanisms of AI-induced pain is critical to improve treatment. However

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23

Κουσίδου, Όλγα. "Βιοχημική και κυτταρική μελέτη της διαμεσολαβούμενης σηματοδότησης από οιστρογονοϋποδοχείς στον καρκίνο του μαστού". Thesis, 2007. http://nemertes.lis.upatras.gr/jspui/handle/10889/3769.

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