Готові списки джерел за темами / Estrogenic endocrine disruptors

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Добірка наукової літератури з теми "Estrogenic endocrine disruptors"

Автор: Grafiati

Опубліковано: 26 липня 2023

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Статті в журналах з теми "Estrogenic endocrine disruptors"

Munteanu, Constantin, and Mihai Hoteteu. "Estrogenic compounds – endocrine disruptors." Balneo Research Journal 2, no. 4 (December 20, 2011): 115–18. http://dx.doi.org/10.12680/balneo.2011.1021.

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Liu, Yan Qun, and Xiong Bing Lu. "Establishing a Assay for Detection of Nonylphenol Estrogenic Effects." Applied Mechanics and Materials 71-78 (July 2011): 3003–6. http://dx.doi.org/10.4028/www.scientific.net/amm.71-78.3003.

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Environmental estrogen could mimic natural estrogens thereby disrupting the endocrine systems of human and animals. The actions of such endocrine disruptors have been studied mainly on reproduction and development. To explore the estrogenic effects of NP by reporter genebased assays we developed. pERE-GFP plamid was generated by inserting estrogen response element fragment into pGADD153-GFP. the recombinant was confirmed by restriction enzyme map and transfected into SPC-A1 cells to ensure the expression of green fluorescent protein．The assay we established in usful, NP could induce the estrogenic activities at any of the tested concentrations.

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Santti, Risto, Sari Mäkelä, Leena Strauss, Johanna Korkman, and Marja-Lsa Kostian. "Phytoestrogens: Potential Endocrine Disruptors in Males." Toxicology and Industrial Health 14, no. 1-2 (January 1998): 223–37. http://dx.doi.org/10.1177/074823379801400114.

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Exposure to diethylstilbestrol (DES) induces persistent structural and functional alterations in the developing reproductive tract of males. It is possible that xenoestrogens other than DES alter sexual differentiation in males and account for the increasing incidence of developmental disorders of the reproductive tract in men and wild animals. Phytoestrogens (coumestans, isoflavonoids, flavonoids, and lignans) present in numerous edible plants are quantitatively the most important environmental estrogens when their hormonal potency is assessed in vitro. They exert their estrogenic activity by interacting with estrogen receptors (ERs) in vitro. They may also act as antiestrogens by competing for the binding sites of estrogen receptors or the active site of the estrogen biosynthesizing and metabolizing enzymes, such as aromatase and estrogen-specific 17β-hydroxysteroid oxidoreductase (type 1). In theory, phytoestrogens and structurally related compounds could harm the reproductive health of males also by acting as antiestrogens. There are very little data on effects of phytoestrogens in males. Estrogenic effects in wildlife have been described but the evidence for the role of phytoestrogens is indirect and seen under conditions of excessive exposure. In doses comparable to the daily intake from soy- based feed, isoflavonoids such as genistein were estrogen agonists in the prostate of adult laboratory rodents. When given neonatally, no persistent effects were observed. In contrast, the central nervous system (CNS)-gonadal axis and the male sexual behavior of the rat appear to be sensitive to phytoestrogens during development. The changes were similar but not identical to those seen after neonatal treatment with DES, but higher doses of phytoestrogens were needed.There are no data on effects of phytoestrogens given as pure compounds to humans, and all evidence currently available is indirect and based on experiments with phytoestrogen- rich diets. The hormonal effects have so far been marginal. It is known that the intake of phytoestrogens is higher in countries where the incidence rates of clinical conditions linked to estrogen exposure, such as hypospadia or testicular and prostatic cancers, are low. This makes it unlikely that phytoestrogens, or structurally related compounds in amounts present in Asian diets, would have DES-like actions. This does not exclude possibilities that they influence concentrations of endogenous sex hormones and interact with the ER, and that through these mechanisms they alter male sex differentiation, and consequently increase the risks of male genital tract tumors or developmental disorders, particularly in doses exceeding the daily intake of phytoestrogens in Asian diets.

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Gea, Marta, Chao Zhang, Roberta Tota, Gianfranco Gilardi, Giovanna Di Nardo, and Tiziana Schilirò. "Assessment of Five Pesticides as Endocrine-Disrupting Chemicals: Effects on Estrogen Receptors and Aromatase." International Journal of Environmental Research and Public Health 19, no. 4 (February 10, 2022): 1959. http://dx.doi.org/10.3390/ijerph19041959.

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Pesticides are widely applied all over the world, and pesticide exposure can induce different biological effects posing a possible threat to human health. Due to their effects on the endocrine system, some pesticides are classified as endocrine disruptors. The aim of the study is to assess the interference of five pesticides on estrogen biosynthesis and estrogen signaling. Three neonicotinoid insecticides (Acetamiprid, Clothianidin, and Thiamethoxam), a carbamate insecticide (Methiocarb) and a herbicide (Oxadiazon) were tested. The effect of pesticides on estrogen biosynthesis was studied through an ELISA assay using a recombinant form of human aromatase, the enzyme that catalyzes the transformation of androgens to estrogens. Moreover, the effect of pesticides on estrogen signaling was assessed using a gene reporter assay on MELN cells, which measures estrogen receptor-mediated estrogenic activity. The results of the ELISA assay showed that the pesticides did not alter aromatase activity (no interference with estrogen biosynthesis), while the results of the gene reporter assay showed that only Methiocarb was able to alter estrogen signaling at high doses. The estrogenic activity of Methiocarb, expressed as 17β-estradiol equivalency factor (EEF), was equal to 8.0 × 10−8. In conclusion, this study suggested that Methiocarb should be considered a potential endocrine disruptor.

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Schooling, C. M., and J. Zhao. "Estrogenic endocrine disruptors and autoimmune disease." International Journal of Epidemiology 44, no. 1 (July 4, 2014): 363–64. http://dx.doi.org/10.1093/ije/dyu133.

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Kiyama, Ryoiti, and Yuko Wada-Kiyama. "Estrogenic endocrine disruptors: Molecular mechanisms of action." Environment International 83 (October 2015): 11–40. http://dx.doi.org/10.1016/j.envint.2015.05.012.

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Nekvapil, Tomáš, Ivana Borkovcová, Miriam Smutná, and Zdeňka Svobodová. "Estrogenic Profile of the Svratka and Svitava Rivers in the Brno Area." Acta Veterinaria Brno 78, no. 2 (2009): 313–17. http://dx.doi.org/10.2754/avb200978020313.

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Estrogens are chemical compounds considered to be endocrine disruptors. They are thought to affect the endocrine system even at low concentrations found in water (ng l-1). The aim of this work was to determine estrogenic compound levels in the rivers in the Brno area. The concentration of 17β-estradiol, ethynylestradiol, estrone and diethylstilbestrol was estimated in the water samples collected in the Svratka and Svitava rivers. Estrogens were isolated from the samples using solid-phase extraction with Oasis HLB cartridges and determined by means of reversed phase HPLC with UV detection. The detection limit of the method used was 6 ng l-1, repeatability expressed as RSD was 11%, and recovery was 87 - 103%. Estrogen values detected ranged in the interval of 6-209 ng l-1, depending on the sampling site. After treatment in the sewage water treatment plant, the water displayed markedly lower levels of estrogenic compounds. The results of the experiment demonstrate that HPLC-UV is a suitable method for determination of low concentrations of estrogens in water. The sewage water treatment plant reduces concentrations of estrogens but not sufficiently to prevent their estrogenic effect on fish.

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Sikka, Suresh C., and Run Wang. "Endocrine disruptors and estrogenic effects on male reproductive axis." Asian Journal of Andrology 10, no. 1 (January 2008): 134–45. http://dx.doi.org/10.1111/j.1745-7262.2008.00370.x.

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Wormsbaecher, Clarissa, Andrea R. Hindman, Alex Avendano, Marcos Cortes-Medina, Jonathan W. Song, and Craig J. Burd. "Abstract 2687: The estrogenic activities of endocrine disruptors alter the extracellular matrix and tissue stiffness in the mammary gland." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2687. http://dx.doi.org/10.1158/1538-7445.am2022-2687.

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Abstract In utero exposure to estrogenic endocrine disrupting compounds (EDCs) increases a woman’s lifetime risk of breast cancer. Similarly, mice exposed in utero to the estrogenic EDC bisphenol A (BPA) have increased susceptibility to mammary gland tumors. It is unclear which BPA-induced alterations predispose the mammary gland to cancer transformation. There is a critical need to understand the mechanisms that drive increased cancer risk in order to assess the impact of BPA and BPA alternatives that retain estrogenic activity. We have utilized in utero BPA exposure as a model system for in utero estrogenic endocrine disruption to study the long-term consequences to the mouse mammary stroma. We found that BPA exposed fibroblasts showed significant transcriptional deregulation, with the extracellular matrix being the most altered cellular component and multiple collagen genes being more highly expressed. The fibroblasts from the BPA exposed mice decreased fluid permeability of the extracellular matrix, indicative of an increased density in the extracellular matrix. Also, in utero BPA exposure increased mammary gland stiffness. Changes to breast density, stiffness, and collagen deposition are all associated with breast cancer risk. Further, we test BPA alternative compounds with varying affinities for the estrogen receptor in our in utero model to assess the phenotypes in the mouse mammary stroma which are associated with breast cancer risk. Additionally, we use a mesenchymal estrogen receptor alpha (ERα) knockout mouse model to dissect the in utero cellular target of EDCs. Citation Format: Clarissa Wormsbaecher, Andrea R. Hindman, Alex Avendano, Marcos Cortes-Medina, Jonathan W. Song, Craig J. Burd. The estrogenic activities of endocrine disruptors alter the extracellular matrix and tissue stiffness in the mammary gland [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2687.

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Jung, Eui-Man, Beum-Soo An, Hyun Yang, Kyung-Chul Choi, and Eui-Bae Jeung. "Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors." International Journal of Environmental Research and Public Health 9, no. 3 (February 24, 2012): 698–711. http://dx.doi.org/10.3390/ijerph9030698.

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Більше джерел

Дисертації з теми "Estrogenic endocrine disruptors"

Swart, Johannes Cornelius. "The development and implementation of biomarker assays for estrogenic endocrine disruptors." Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6792_1258011445.

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'Endocrine disrupting chemicals (EDCs) are compounds found in the environment that have the potential to disrupt normal endocrine function. Estrogenic EDCs (e-EDCs) is a subclass of EDCs and is defined as substances contaminating the environment that may mimic or inhibit the effect of endogenous estrogen and therefore may influence developmental and reproductive health in humans and animals. The aim of this study was to develop, validate and implement a battery of in vitro and in vivo screening assays for e-EDCs. The study was concluded by implementing this battery of assays to assess the Eerste River, South Africa at three sampling sites, namely Jonkershoek, Stellenbosch sewage treatment works (STW) effluent and Spier for e-EDCs. The control site, Jonkershoek contained very low levels of estrone. Water from this site showed no estrogenic activity when the E-screen and the ER_ induction in MCF-7 cells. Some of the water samples collected at this site tested positive for estrogenicity when analysed with the juvenile tilapia VTG assay, whereas the rest were negative. The estrone levels in the sewage effluent extracts as well as Spier were significantly higher. The assay using ER_ protein induction by the MCF-7 cell line, the MCF-7 proliferation assay and the tilapia in vivo screen for estrogenicity showed that these samples are estrogenic. Results obtained for estrogenicity at the three different sampling sites for each of the assays in the battery were comparable. In this study we developed, validated and also implemented a battery of assays encompassing both in vitro and in vivo assays, based on different biological mechanisms, to detect estrogenic EDCs. To our knowledge, this is the first study that has used a battery of bioassays to specifically assess a South Africa river for estrogenicity...'

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Al-Jandal, Noura. "The effects of estrogenic endocrine disruptors on the osmoregulatory functions in euryhaline fish." Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3131.

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Osmoregulation is an essential process to maintain water and ionic balance and when euryhaline fish move between freshwater and seawater environments as part of their life cycle this presents additional osmoregulatory challenges. Migrating fish can be exposed in both environments to pollutants such as endocrine disrupting chemicals (EDCs) that include natural hormones (e.g. 17β-estradiol; E2), synthetic hormones (e.g. 17α-ethinylestradiol; EE2), and industrial chemicals (e.g. nonylphenol). The focus of this thesis was to study the effects of different categories of EDCs on the osmoregulatory functions of euryhaline fish such as three-spined sticklebacks (Gasterosteus aculeatus) and rainbow trout (Oncorhynchus mykiss). Osmoregulatory variables (such as osmolality, water and ionic content) were compared in plasma and tissues (white muscle and carcass) of rainbow trout. This validated the use of specific tissue parameters as a surrogate of plasma responses to various osmoregulatory challenges. Waterborne exposure to 17α-ethinylestradiol revealed differential sensitivity of vitellogenesis in the three-spined sticklebacks (no induction) and rainbow trout, but had a significant effect on calcium homeostasis in both species. Intraperitoneal implants of 17β-estradiol reduced CaCO3 production and apparent water absorption in the intestine and increased in tissue calcium stores of seawater-acclimated trout, but fish were able to compensate and showed no overall osmoregulatory disturbance. Waterborne exposure to nonylphenol in freshwater trout was also investigated, but no effects on osmoregulation were found up to 2 ng/l. Overall, estrogens can affect osmoregulation differentially in euryhaline fish species, and sometimes at EDC levels lower than the threshold for reproductive effects (i.e. vitellogenin induction).

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Teske, Sondra Sue Gery. "Aspects of Measuring Mass Balances of Endocrine Disrupting Compounds through Wastewater Treatment." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194944.

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Ecological impacts of natural estrogens and xenoestrogens in treated wastewater include altered sexual development and sex ratios among continuously exposed organisms. The primary sources of estrogenic activity in wastewater are natural estrogens such as estrone, 17β-estradiol and estriol and synthetic compounds like 17α- ethinylestradiol, alkylphenols and alklphenol ethoxylates. Precursors in raw wastewater can yield estrogenic intermediates during wastewater treatment. All these compounds can be destroyed by biochemical processes conventional wastewater treatment processes, suggesting that conventional processes can be optimized for removal of estrogenic activity from wastewater. Sorption to sludges derived from wastewater treatment affects the fates of hydrophobic xenoestrogens such as nonylphenol, in part because the biodegradability of sorbed contaminants is limited. It may also be possible to tailor sludge stabilization processes to remove trace contaminants, including estrogens. For example, there are significant differences in the efficiencies of aerobic and anaerobic digestion for destruction of alkylphenols and probably other estrogenic compounds with aromatic moieties. Because advanced wastewater treatment is not economically feasible for most communities, there is ample incentive to develop accurate relationships between operational parameters and removal of estrogenic compounds during secondary wastewater treatment. Large quantities of polybrominated diphenyl ethers (PBDEs) have been used as flame retardants in clothing and plastic products since the 1970s. A small fraction of the PBDEs in manufactured products subsequently enters municipal wastewater. The resistance of these compounds to chemical and biochemical transformations provides opportunities for accumulation in sediments. Balances developed for PBDE congeners indicate that conventional wastewater treatment processes and soil infiltration of treated wastewater in recharge operations do not discriminate significantly among the major congeners in commercially available PBDE products. Accumulation of PBDEs at near part-per-million levels was measured in the sediments at the Sweetwater Recharge Facility in Tucson, Arizona, during 10-15 years of operation. Half times for loss of major PBDE congeners from sediments were decades or longer. Local agricultural soils amended with biosolids over a 20-year period showed similar accumulation of PBDEs. The widespread use of PBDEs in commercial products, compound persistence and toxicity indicate that additional effort is warranted to better understand fate-determining processes for PBDEs in the environment.

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Blavier, Julie. "Degradation of estrogenic endocrine disruptors by laccases: from estrogenicity monitoring methods to reactor design." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/222520.

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In the past decades, much concern has been expressed regarding organic micropollutants generating endocrine disruption. In particular, estrogenic endocrine disruptors, compounds that interfere with the estrogenic hormonal mechanisms, are in the center of environmental scien- tists attention. Numerous endocrine disrupting effects have been observed at concentrations corresponding to those found in aquatic environments, such as feminization of fauna, infertility, reproductive disturbance, cancer, or developmental disruption. Wastewater treatment plants ef- fluents have been identified as the main source of estrogenic endocrine disruptors in the aquatic environment, due to inappropriate treatment. Promising alternative treatment systems based on the use of ligninolytic enzymes (e.g. laccases) have recently emerged. This work falls within the framework of these new techniques. Althoughno environmentally safe threshold can clearly be set, focusing on the removal of global estrogenicity in water instead of concentrations of targeted estrogenic compounds seems a relevant research. To our knowledge, the use of these recently emerged enzymatic processes at an industrial scale (such as for the treatment of urban wastewater), oriented towards water overall estrogenicity, has not been implemented yet.The general objective of this work was to develop ans study a process of removal of estro- genicity by laccases from white-rot fungi, in laboratory, with the purpose of design and scale-up for industrial implementation. This work consisted of the conception, characterization, testing, study and modeling of this process.First, in order to enable the study and the scaling-up of a process of estrogenicity removal, op- timizing the technologies of quantification of estrogenicity in water was a real necessity. Therefore, a study of the methods of estrogenicity monitoring, within a treatment process framework, was conducted. Based on a wide literature review, existing methods were gathered and assessed with the aim of their use as monitoring and design tools. Fromthat review, four methods were selected and tested according to numerous criteria and their compatibility with our process: three bioassays (Yeast Estrogen Screen assay; Lyticase-assisted Yeast Estrogen Screen assay; MCF-7 cell based reporter gene assay) and one analytical method (High Performance Liquid Chromatography with UV detection, HPLC-UV). Concentration-response curves towards the reference 17β-estradiol, in several solvents, were acquired. A fitting model was developed for further expression of all measurements in Estradiol Equivalents. The methods were used to evaluate the estrogenicity of bisphenol A, triclosan and nonylphenol, along with estrogenicity of mixtures of bisphenol A and 17β-estradiol. The testing of these four methods enabled the assessment of their sensitivity, re- producibility, and implementation. Based on that experimental assessment, the Lyticase-assisted Yeast Estrogen Screen (LYES) assay was selected and systematized to be further applied, in combination with an adapted protocol of HPLC-UV analysis, to the monitoring of estrogenicity removal in two lab-scaled reactors. The LYES assay demonstrated a real methodological potential for thescale-up of an estrogenicity removal process and could be used as a design tool. For both reactors, results have indicated that HPLC-UV and LYES assay methods are completely inter- changeable in the case of bisphenol A monitoring (in the conditions used in this work). This work also highlighted the peculiar behavior of mixtures of bisphenol A and 17β-estradiol in terms of estrogenicity, and the parallel observation of an enhancement of bisphenol A estrogenicity removalin presence of 17β-estradiol.In the second part of this work, a batch reactor with laccases in solubilized form was developed and estrogenicity removal was assessed. Kinetics data for the degradation of estrogenic endocrinedisruptors were acquired with the LYES assay (estrogenicity) and the HPLC-UV method (concen- trations). Degradations were performed from several solutions of bisphenol A, 17β-estradiol, and mixtures. In the case of 17β-estradiol and mixtures, conversions reached minimum 90% within 1 hour of degradation at our conditions, with no dependency on pollutant initial concentrations. In the case of bisphenol A, conversions varied from 0 to 100% after 6 hours of degradation and were shown tobe strongly dependent on BPA initial concentrations, indicating the laccases deac- tivation by substrate. Bisphenol A byproducts of degradation were also analyzed, which indicated their absence of estrogenicity and their potential linear evolution with BPA degradation. Acquired kinetics data were exploited for the modeling of the batch degradations kinetics. At this stage of the work, no clear kinetics conclusions could be made in this part.From an industrial point of view, the use of immobilized enzymes is more cost-effective, due to the improvement of enzymes recovery and stability. Therefore, in the third part of this work, a continuous column-shaped packed-bed reactor composed of laccases immobilized on a silica support was developed. The packed-bed reactor was built and tested in laboratory. Residence time distributions, pressure drop calculations, and tracer degradations were performed on the re- actor for its characterization.Immobilization and activity measurements protocols were applied. Similar monitoring than in the batch reactor (LYES assay and HPLC-UV) were performed during continuous degradations of bisphenol A, 17β-estradiol, and mixtures in the packed-bed reactor. Acquired kinetics data were exploited to study and model the kinetics occurring in the packed-bed reactor. Mass transfer phenomena and laccases deactivation by substrate in the reactors were investigated and modeled, revealing, depending on the pollutant, the presence of slight external mass transfer limitation and the strong dependence of the kinetics on laccases deactivation. A design tool, in the form of a mathematical model for the design of a packed-bed reactor with immobilized laccases for the degradation of bisphenol A and related estrogenicity, was developed. The model was validated (simple validation) on experimental data. The model was then used, as a comparison, for the design of a reactor with similar conditions than a documented technique of bisphenol A degradation by ozone. The design resulted in a reactor twice smaller than for degradation by ozone, for the same conversion.In the current context of environmental crisis, this work proposed a first version of a promising practical solution for the treatment of environmentally problematic e-EDCs, oriented towards water overall estrogenicity monitoring and removal, and using natural biocatalysts.
Doctorat en Sciences de l'ingénieur
info:eu-repo/semantics/nonPublished

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Le, Fol Vincent. "Approche in vivo/in vitro du métabolisme de perturbateurs endocriniens chez le poisson zèbre (Danio rerio)." Phd thesis, Toulouse, INPT, 2015. http://oatao.univ-toulouse.fr/15125/1/lefol_1.pdf.

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Les perturbateurs endocriniens (PE) posent des risques pour la santé Humaine et pour la faune. L’utilisation de tests biologiques basés sur des mécanismes d’action spécifiques permet de caractériser le potentiel PE des substances chimiques dans le cadre de l'évaluation toxicologique, mais les capacités de biotransformation de ces modèles sont rarement prises en compte. Or, le métabolisme conditionne le devenir des xénobiotiques (détoxication vs. bioactivation) et donc in fine l'activité biologique mesurée. Dans ce travail, le devenir de deux contaminants œstrogéniques émergents (benzophénone-2, bisphénol S) a été comparé dans de nouveaux modèles in vitro et in vivo de poisson zèbre (cellules ZELH-zfERs, larve transgénique cyp19a1b-GFP) et des lignées humaines. Nos résultats démontrent que les modèles de poissons zèbres sont métaboliquement compétents et soulignent leur pertinence dans une approche intégrée in vivo/in vitro pour le criblage de l'activité PE des substances chimiques.

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Cox, Brian Joseph. "Development of an assay for estrogenic endocrine disrupters involving the rat liver estrogen receptor alpha." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ31820.pdf.

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Wu, Fei. "Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2433.

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Zhao, Zunyang. "Removal of Estrogens at Full and Pilot Scale Livestock Manure Treatment Systems." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/26067.

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Three experiments were conducted to 1) develop appropriate methods for livestock manure estrogen analysis; 2) determine estrogen removal in different manure treatment systems; and 3) determine estrogen removal from dairy manure in pilot scale reactors. In Experiment I, the recoveries of 17Ã -estradiol (E2) and estriol (E3) were evaluated in double distilled water and dairy manure after a base extraction and analysis of estrogens by enzyme-linked immunoassay (ELISA) and yeast estrogen screen (YES) assay. The recoveries of E2 were 104% (ELISA) and 97% (YES) in double distilled water. 112% of E2 and 79% of E3 in flushed dairy manure and 118% of E2 in anaerobic digester effluent were recovered with ELISA. 67% and 140% of E2 in flushed manure and anaerobic digester effluent, respectively, were recovered with YES assay. In Experiment II, samples were collected from a full-scale manure handling system incorporating separation and aeration (Separation/Aeration), an anaerobic digester receiving dairy manure (Anaerobic Digester), and four conventional dairy and swine manure storages. 70% of E2 (230 vs. 769 Î¼g/cow/day) and 86% of E3 (78 vs. 552 Î¼g/cow/day) mass were removed from the Separation/Aeration system when the effluent was compared to the influent; the ratio of E2 to total estrogenicity (E2-eq) averaged 76%. In the Anaerobic Digester, 38% of E2 (592 vs. 954 Î¼g/cow/day) and 30% of E3 (338 vs. 483 Î¼g/cow/day) mass were removed; E2 contributed more to E2-eq in the influent than in the effluent (43 vs. 26%). There was no significant difference for E2-eq (431 vs. 284 ng/g of total solids) and E2 (248 vs. 73 ng/g of total solids) concentrations between barn and pti in conventional dairy manure storages; E2 contributed more to E2-eq in barn manure than in pit manure (54 vs. 30%). In swine manure storages, both E2-eq (2852 vs. 1551 vs. 148 ng/g of total solids) and E2 (1933 vs. 808 vs. 89 ng/g of total solids) concentrations decreased (barn vs. primary lagoon vs. secondary lagoon; no significance analysis); the change of E2 ratio to E2-eq was not consistent between barn and lagoon manures between farms. In Experiment III, samples were collected from six pilot scale reactors: two aerated reactors (60% and 100% aeration; AER60 and AER 100), a nitrifying/denitrifying reactor (NDN), an enhanced biological phosphorus removal reactor (EBPR), an anaerobic digester (AD), and a nitrifying reactor (NI) following AD. The influent had higher mass of E2 and E2-eq than the effluent with all reactors. Estrogen removal efficiencies were expressed in two ways: % and %/aerobic hour (or hour) of the influent mass. Higher ammonia nitrogen removing reactors had higher E2 and E2-eq removal in %, higher E2 removal in %/aerobic hour, and the same E2-eq removal in %/aerobic hour compared to those with lower ammonia nitrogen removal. Estrogen removal efficiencies (both in % and %/aerobic hour) were similar in nitrifying and denitrifying reactors. Reactors with aeration supported greater estrogen removal than those without. Reactors with influent anaerobic digestion pretreatment had the same E2 and E2-eq removal in % but higher E2 and E2-eq removal in %/aerobic hour compared to those without. In conclusion, the aerobic treatment system removed more estrogens than the anaerobic one, which means aerobic conditions support more estrogen degradation than anaerobic conditions. The change of the ratios of E2 to E2-eq varied in different livestock manure treatment systems, which reflected different removal rates of E2 and other estrogenic compounds. The pilot scale reactors significantly removed E2 and E2-eq in dairy manure. Ammonia nitrogen removal rates and aeration are the two main factors influencing E2 and E2-eq removal.
Ph. D.

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Kwekel, Joshua Caleb. "Cross-species comparison of estrogenic endocrine disruptor-induced, uterotrophic gene expression in the rodent." Diss., Connect to online resource - MSU authorized users, 2008.

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Shimada, Kiyoshi, Yonju Ha, Akira Tsukada, Noboru Saito, Shinobu Maekawa, Makoto Nishizuka, and Masayoshi Imagawa. "In vivo and in vitro screening of endocrine disrupting chemicals with estrogenic activity in Japanese quail." Science Reviews 2000 Ltd, 2005. http://hdl.handle.net/2237/9265.

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Книги з теми "Estrogenic endocrine disruptors"

K, Naz Rajesh, ed. Endocrine disruptors: Effects on male and female reproductive systems. Boca Raton: CRC Press, 1999.

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K, Naz Rajesh, ed. Endocrine disruptors: Effects on male and female reproductive systems. 2nd ed. Boca Raton: CRC Press, 2005.

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Naz, Rajesh K. Endocrine Disruptors. Taylor & Francis Group, 2019.

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Atta-ur-Rahman and Khurshid Zaman, eds. Topics in Anti-Cancer Research: Volume 8. BENTHAM SCIENCE PUBLISHERS, 2019. http://dx.doi.org/10.2174/97898114043821190801.

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Topics in Anti-Cancer Research covers new developments in the field of cancer. Novel drugs as anticancer agents include natural and synthetic phenazines and other anti-cancer compounds. It also encompasses the role of estrogen as endocrine disruptors and strategies targeting cancer stem cells for the treatment of different types of cancers, including myeloma and renal cell cancer. The diversity of researches and topics published in this eBook Series will be valuable to cancer researchers, clinicians, and cancer professionals aiming to develop novel anti-cancer targets for the treatment of various cancers. The topics covered in the eighth volume of this series are as follows: Novel Drugs for Multiple Myeloma Synthetic Estrogens are Endocrine Disruptors via Inhibition of AF1 Domain of ERs Recent Progress of Phenazines as Anticancer Agents Cancer Stem Cell Targeting for Anticancer Therapy: Strategies and Challenges

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Naz, Rajesh K. Endocrine Disruptors: Effects on Male and Female Reproductive Systems. Taylor & Francis Group, 2010.

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Naz, Rajesh K. Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition. Taylor & Francis Group, 2004.

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Naz, Rajesh K. Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition. Taylor & Francis Group, 2004.

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Naz, Rajesh K. Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition. Taylor & Francis Group, 2004.

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Naz, Rajesh K. Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition. Taylor & Francis Group, 2004.

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Частини книг з теми "Estrogenic endocrine disruptors"

Inui, Hideyuki, Hideaki Sasaki, Susumu Kodama, Nam-Hai Chua, and Hideo Ohkawa. "Monitoring of Endocrine Disrupters in Transgenic Plants Carrying Aryl Hydrocarbon Receptor and Estrogen Receptor Genes." In ACS Symposium Series, 40–47. Washington, DC: American Chemical Society, 2004. http://dx.doi.org/10.1021/bk-2005-0892.ch004.

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Kucheryavenko, Olena, Silvia Vogl, and Philip Marx-Stoelting. "Chapter 1. Endocrine Disruptor Effects on Estrogen, Androgen and Thyroid Pathways: Recent Advances on Screening and Assessment." In Issues in Toxicology, 1–24. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839160738-00001.

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Richter, Catherine A., Barry G. Timms, and Frederick S. vom Saal. "Prostate Development: Mechanisms for Opposite Effects of Low and High Doses of Estrogenic Chemicals." In Endocrine Disruptors, 379–410. CRC Press, 2004. http://dx.doi.org/10.1201/9781420038866-12.

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Safe, S., I. Jutooru, and G. Chadalapaka. "Estrogenic Endocrine Disruptors: Molecular Characteristics and Human Impacts." In Comprehensive Toxicology, 609–21. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-08-046884-6.00234-7.

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Safe, S., I. Jutooru, U. H. Jin, and G. Chadalapaka. "Estrogenic Endocrine Disruptors: Molecular Characteristics and Human Impacts." In Comprehensive Toxicology, 450–62. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-801238-3.95616-2.

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Karadağ, Makbule Gezmen, and Teslime Özge Şahin. "Beslenme ile Alınan Endokrin Bozucuların Nörolojik Hastalıklar Üzerindeki Olası Rolü." In Endokrin Bozucular ve Sağlık, 217–42. Türkiye Bilimler Akademisi Yayınları, 2022. http://dx.doi.org/10.53478/tuba.978-625-8352-04-7.ch13.

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Endocrine disruptors are compounds that are usually taken into the body through nutrition, breathing and contact, or by placentally. Once these compounds are taken into the body, they can have an effect that increases or reduces the effects of hormones that regulate metabolism by various mechanisms. There is a chronic exposure to these compounds, especially through nutrients and equipment used in food storage and preparation. Studies on the health effects of these compounds, which have become an integral part of daily life, are increasing day by day. Although the first studies on this subject focus on the reproductive system due to its estrogenic and androgenic mechanisms of action, there are many studies today that reveal its effects on diabetes, cancer, cardiovascular and neurological diseases. In this section, the acute neurotoxic effects of endocrine disruptors taken with food, as well as their potential roles in neurodevelopmental disorders, Alzheimer's and Parkinson's diseases are examined.

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"Receptor-Mediated Toxicity: QSARs for Estrogen Receptor Binding and Priority Setting of Potential Estrogenic Endocrine Disruptors." In Predicting Chemical Toxicity and Fate, 306–35. CRC Press, 2004. http://dx.doi.org/10.1201/9780203642627-26.

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Erkekoğlu, Pınar. "Plastikleştiriciler; Ftalatlar ve Bisfenoller." In Endokrin Bozucular ve Sağlık, 35–64. Türkiye Bilimler Akademisi Yayınları, 2022. http://dx.doi.org/10.53478/tuba.978-625-8352-04-7.ch03.

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The functioning of the endocrine system can be affected by many factors. Endocrine-disrupting chemicals are environmentally abundant exogenous agents with different chemical structures, and they can affect the synthesis, secretion, transport, metabolism, binding, or elimination of hormones. It is known that humans are exposed to many endocrine disruptors at the same time in daily life. Phthalates and bisphenols are substances that are used as plasticizers in plastics and are produced and used in large quantities around the world. Phthalates are generally used to soften plastic, while bisphenols are used to shape polycarbonate plastics. It is stated that phthalates are substances with anti-androgenic effects and may have unwanted effects on many organs and systems, especially on the developing male reproductive system. In recent years, their neuroendocrine effects have been frequently emphasized. On the other hand, Bisphenols are generally known as estrogenic chemicals and are associated with obesity, diabetes, and different types of cancer, apart from their effects on the endocrine system. Humans have intense contact with both groups of plasticizers at the same time. While serious questions remain about the full effects of individual exposure to these substances, extensive and mechanistic studies are needed to evaluate the effects of combined exposure. In particular, prenatal and early postnatal exposure should be reduced. Therefore, precautions should be taken, especially during pregnancy. It is of great importance for the health of future generations to raise awareness of the public, especially about reducing plasticizer exposure

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Soto, A. M., and C. Sonnenschein. "Estrogens, Xenoestrogens, and the Development of Neoplasms." In Endocrine Disruptors, 175–215. CRC Press, 2004. http://dx.doi.org/10.1201/9781420038866-6.

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Soto, A., and C. Sonnenschein. "Estrogens, Xenoestrogens, and the Development of Neoplasms." In Endocrine Disruptors, 175–215. CRC Press, 2004. http://dx.doi.org/10.1201/9781420038866.ch6.

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Тези доповідей конференцій з теми "Estrogenic endocrine disruptors"

Islam, Nazmul. "Real-Time Detection of Estrogen by Microcantilever Sensor in Microfluidic Channel." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68903.

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As the world becomes increasingly concerned with endocrine disruptor from estrogenic activity, and since the threat of estrogen can be substantially mitigated if detected early, the demand for real-time/on-site detection of estrogen is expanding quickly. However, current technology is expensive, technically complicated and not available for estrogen level determination at the contamination sites. The primary objective of this research is to develop and validate a robust, rapid lab-on-chip for detecting estrogen in environmental water samples. Anti-estrogen antibodies can be layered to the microcantilever (MC) surface through passive adsorption using a dilute solution of antibody. The estrogen in the water will bind/react with antibody, which will result in a strain in the cantilever. The strain of the cantilever can ultimately be measured as a resistance change in the microsystem. MC will be integrated with AC electokinetic to produce a lab-on-a-chip that can concentrate measure and differentiate viable estrogen.

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