Готові списки джерел за темами / Extrinsic Aging And Photoaging

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Добірка наукової літератури з теми "Extrinsic Aging And Photoaging"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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Статті в журналах з теми "Extrinsic Aging And Photoaging"

Asyi, Muhammad Shanan, Dedy Syahrizal, Nirwana Lazuardi Sary, and Fauzul Husna. "The Impact of Photoaging on Skin: A Systematic Review Analysis." Journal of Social Research 3, no. 1 (2023): 209–15. http://dx.doi.org/10.55324/josr.v3i1.1708.

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Aging of the skin is a complex biological process. The process of skin aging can be divided into two categories namely intrinsic and extrinsic aging. Intrinsic skin aging or natural aging is caused by changes in skin elasticity that occur with age. This type of aging cannot be prevented. While extrinsic skin aging is caused by environmental factors such as exposure to solar radiation (photoaging). In this study, the type of research approach used is a type of qualitative research through a literature review. The type of data used is the type of secondary data. Secondary data is a type of data

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Takemori, Kumiko, Ei Yamamoto, Takaaki Chikugo, Eri Shiratsuchi, and Takashi Kometani. "DPP-IV Inhibition by Solubilized Elastin Peptides from Yellowtail Bulbus Arteriosus Suppresses Ultraviolet-B-Induced Photoaging in Hairless Mice." Nutraceuticals 4, no. 4 (2024): 683–94. https://doi.org/10.3390/nutraceuticals4040038.

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Skin aging is intrinsic and extrinsic. Intrinsic, or chronological, skin aging is an inevitable process of chronological and physiological alterations. The factors contributing to extrinsic skin aging involve sunlight, nutrients, and stress. Thus, extrinsic aging is thought to be superimposed over intrinsic aging and depends on the intensity and duration of environmental exposure and skin type (e.g., dry skin, oily skin, or eczema). The most significant extrinsic aging factor is UV radiation, which causes cellular senescence in a process known as photoaging. This study aimed to illuminate the

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Trivedi, Madhvi, Rajesh Dutt Mehta, Bhikam Chand Ghiya, and Prasoon Soni. "Cutis Rhomboidalis Nuchae and Solar Lentigo with Squamous and Basal Cell Carcinoma – A Quartet of Chronic Sun Exposure." Journal of the Indian Academy of Geriatrics 20, no. 3 (2024): 161–63. http://dx.doi.org/10.4103/jiag.jiag_32_23.

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Abstract Aging is of two types, namely extrinsic and intrinsic aging. Extrinsic aging or photoaging is caused mainly due to damage caused by solar radiation. We report the case of a elderly male who presented with large growth on the scalp and ulcer on the face. However, on clinical examination, almost all the changes of photoaging, namely solar lentigo, cutis rhomboidalis nuchae squamous, and basal cell carcinoma were present. This case highlights the importance of thorough clinical examination needed in the geriatric population for the early diagnosis and timely management of their ailments.

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Wang, Vania, Yash Chhabra, Laura Hueser, Sneha Pramod, Alexis Carey, and Ashani Weeraratna. "Abstract 1274: Extrinsic photoaging vs intrinsic aging in dermal fibroblasts: Its impact on the microenvironment and melanoma progression." Cancer Research 83, no. 7_Supplement (2023): 1274. http://dx.doi.org/10.1158/1538-7445.am2023-1274.

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Abstract Melanoma is the deadliest form of skin cancer, with its incidence rising disproportionally to other cancers. Chronological aging is a major risk factor in all types of cancer as it has been shown to drive changes in noncancerous cells (stromal and immune) of the tumor microenvironment (TME) to promote tumor initiation and progression. Ultraviolet radiation (UVR) exposure, which is a major risk factor for melanoma, also can cause a physical premature aging phenotype, known as photoaging. Photoaging of the skin often occurs in tandem with chronological aging, and contributes to the phys

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Sanchez, Martina M., Thamidul Islam Tonmoy, B. Hyle Park, and Joshua T. Morgan. "Development of a Vascularized Human Skin Equivalent with Hypodermis for Photoaging Studies." Biomolecules 12, no. 12 (2022): 1828. http://dx.doi.org/10.3390/biom12121828.

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Photoaging is an important extrinsic aging factor leading to altered skin morphology and reduced function. Prior work has revealed a connection between photoaging and loss of subcutaneous fat. Currently, primary models for studying this are in vivo (human samples or animal models) or in vitro models, including human skin equivalents (HSEs). In vivo models are limited by accessibility and cost, while HSEs typically do not include a subcutaneous adipose component. To address this, we developed an “adipose-vascular” HSE (AVHSE) culture method, which includes both hypodermal adipose and vascular c

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Wang, Vania, Yash Chhabra, Laura Hueser, and Ashani Weeraratna. "Abstract 273: Extrinsic photoaging vs intrinsic aging in dermal fibroblasts: Its impact on the microenvironment and melanoma progression." Cancer Research 84, no. 6_Supplement (2024): 273. http://dx.doi.org/10.1158/1538-7445.am2024-273.

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Abstract Melanoma is the deadliest form of skin cancer, with chronological aging as a major negative prognostic factor due to the influence of intrinsic aging on the tumor microenvironment (TME) to promote tumor initiation and progression. Ultraviolet radiation (UVR) exposure, which is a major risk factor for melanoma, also can cause a physical premature aging phenotype, known as extrinsic photoaging, from chronic UVA irradiation of the underlying dermis. Photoaging of the skin often occurs in tandem with chronological aging, and contributes to similar physical alterations in normal skin struc

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Geng, Ruixuan, Seong-Gook Kang, Kunlun Huang, and Tao Tong. "Dietary Isoeugenol Supplementation Attenuates Chronic UVB-Induced Skin Photoaging and Modulates Gut Microbiota in Mice." Nutrients 16, no. 4 (2024): 481. http://dx.doi.org/10.3390/nu16040481.

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Photoaging, the primary cause of skin aging damage, results from chronic ultraviolet (UV) exposure, leading to dryness and wrinkle formation. Nutritional intervention has emerged as a practical approach for preventing and addressing the effect of skin photoaging. The primary aromatic compound isolated from clove oil, isoeugenol (IE), has antibacterial, anti-inflammatory, and antioxidant qualities that work to effectively restrict skin cancer cell proliferation. This investigation delved into the advantages of IE in alleviating skin photoaging using UVB-irradiated skin fibroblasts and female SK

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Sutikno, Lena Margaretha, I. Wayan Sugiritama, and I. Wayan Juli Sumadi. "Goji Berry (Lycium barbarum) Extract as a Potential Anti-Photoaging Agent: A Literature Review." Journal of Advances in Medical and Pharmaceutical Sciences 26, no. 12 (2024): 137–50. https://doi.org/10.9734/jamps/2024/v26i12739.

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Tropical countries worldwide are frequently subjected to high levels of sunlight year-round. This leads to concerns about potential harmful effects, including skin damage resulting from oxidative stress caused by free radicals due to prolonged sun exposure. This results in extrinsic skin aging, or photoaging. Sunscreen, as a primary photoprotection, is commonly recommended to protect the skin from sunlight. However, even sunscreens with high SPF cannot provide 100% protection from damage caused by free radicals generated by UV rays. Therefore, secondary photoprotection such as natural antioxid

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Zamarrón, Alicia, Esther Morel, Silvia Lucena, et al. "Extract of Deschampsia antarctica (EDA) Prevents Dermal Cell Damage Induced by UV Radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin." International Journal of Molecular Sciences 20, no. 6 (2019): 1356. http://dx.doi.org/10.3390/ijms20061356.

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Exposure to natural and artificial light and environmental pollutants are the main factors that challenge skin homeostasis, promoting aging or even different forms of skin cancer through a variety of mechanisms that include accumulation of reactive oxygen species (ROS), engagement of DNA damage responses, and extracellular matrix (ECM) remodeling upon release of metalloproteases (MMPs). Ultraviolet A radiation is the predominant component of sunlight causative of photoaging, while ultraviolet B light is considered a potentiator of photoaging. In addition, different chemicals contribute to skin

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Tong, Tao, Ruixuan Geng, Seong-Gook Kang, Xiaomin Li, and Kunlun Huang. "Revitalizing Photoaging Skin through Eugenol in UVB-Exposed Hairless Mice: Mechanistic Insights from Integrated Multi-Omics." Antioxidants 13, no. 2 (2024): 168. http://dx.doi.org/10.3390/antiox13020168.

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Chronic ultraviolet (UV) exposure causes photoaging, which is primarily responsible for skin damage. Nutritional intervention is a viable strategy for preventing and treating skin photoaging. Eugenol (EU) presents anti-inflammatory and antioxidant properties, promotes wound healing, and provides contact dermatitis relief. This study explored the ability of EU to mitigate skin photoaging caused by UVB exposure in vitro and in vivo. EU alleviated UVB-induced skin photodamage in skin cells, including oxidative stress damage and extracellular matrix (ECM) decline. Dietary EU alleviated skin photoa

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Більше джерел

Дисертації з теми "Extrinsic Aging And Photoaging"

Wilcox, Stephany Vanessa. "Molecular diagnostic approach to determine the degree of photoaging of the skin." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96779.

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Thesis (MScMedSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Context: Excessive exposure to ultraviolet radiation (UV) results in the risk of acquiring long-term harmful effects such as photoaging, which is characterised by deep wrinkles, roughness, dyspigmentation and an increased loss in elasticity. As a result, the detection of photoaging at an early stage is crucial to improving morbidity, whilst preventing the advancement of skin cancer. Aim: The aim of the study was to develop and to validate a diagnostic real-time PCR method in order to establish the gene expression profi

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Ack, Baraly Kylee Tamera. "Extrinsic and Intrinsic Factors Influencing the Positive Memory Bias in Aging." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40117.

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Emotional experiences are more likely to be remembered than more neutral, mundane ones. In young adults, negative information may be particularly memorable. Yet, an interesting change seems to happen in aging: As adults grow older, they may start remembering positive information more often than negative information. This positive memory bias in aging is commonly observed and is often explained in terms of changing time perspectives and motivation across the lifespan (i.e., Socioemotional Selectivity Theory; Carstensen, Isaacowitz, & Charles, 1999). However, few studies have considered the basi

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Nogusa, Shoko Murasko Donna. "Effects of extrinsic and intrinsic factors on age-associated decline in natural killer cell activity during primary influenza infection /." Philadelphia, Pa. : Drexel University, 2010. http://hdl.handle.net/1860/3321.

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Schneider, Sabine [Verfasser], Jean [Akademischer Betreuer] Krutmann, and William [Gutachter] Martin. "Characterization of molecular mechanisms involved in intrinsic and extrinsic skin aging of in situ aged normal human dermal fibroblasts / Sabine Schneider ; Gutachter: William Martin ; Betreuer: Jean Krutmann." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1241824169/34.

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Ruivo, Adriana Pessoa. "Envelhecimento cutâneo: fatores influentes, ingredientes ativos e estratégias de veiculação." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4413.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>O envelhecimento é um processo de degradação progressiva e diferencial que ocorre em todos os órgãos e desta forma a pele não lhe fica indiferente. O envelhecimento cutâneo pode ser intrínseco ou cronológico, aquele que surge com a idade influenciado por fatores genéticos, ou extrínseco ou actínico aquele que surge influenciado por fatores externos tal como o tabaco, poluição, hábitos de vida e predominantemente, a radiação

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Zague, Vivian. "Influência da suplementação com colágeno hidrolisado no metabolismo da matriz extracelular e proliferação de fibroblastos dérmicos humanos derivados de áreas fotoprotegida e fotoexposta, cultivados em monocamada e equivalente dérmico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-08122015-202409/.

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Este trabalho investigou, pela primeira vez, a influência do CH na modulação do metabolismo e proliferação de fibroblastos dérmicos humanos (FDHs) derivados de áreas fotoprotegida e fotoexposta, cultivados em modelo de monocamada. Além disto, foram investigados os efeitos da suplementação com CH na secreção de colágeno tipo I, em modelo de cultura 3D de equivalente dérmico, derivado de matriz produzida exclusivamente por FDHs. O tratamento com CH não influenciou a proliferação celular dos fibroblastos derivados de ambas as áreas, porém modulou expressivamente o metabolismo dos FDHs cultivados

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Boireau-Adamezyk, Elise. "Spectroscopies vibrationnelles (MCR et ATR-FTIR) et Chromatographie Liquide couplée à la Spectrométrie de Masse Haute Résolution (LC-HR-MS) : Outils d’investigation in vivo de l’impact du vieillissement cutané sur le Stratum Corneum aux niveaux tissulaire, supra-moléculaire et moléculaire." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112070/document.

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La peau est l’organe le plus étendu du corps humain. Doté d’une membrane biologique fine appelée la couche cornée, celle-ci le protège du desséchement et des agressions extérieures chimiques ou mécaniques auxquelles le corps humain doit faire face. Ce travail de thèse a consisté, dans un premier temps, à décrire via la littérature existante les effets de l’âge,dûs au vieillissement intrinsèque et extrinsèque,sur la physiologie cutanée du Stratum Corneum (SC).La partie expérimentale basée sur la microscopie vibrationnelle traitera des variations de la fonction barrière et de l’hydratation du SC

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Tomás, Iolanda dos Ramos Hilário. "Relatórios de Estágio e Monografia intitulada “Novas moléculas antienvelhecimento de aplicação tópica”." Master's thesis, 2018. http://hdl.handle.net/10316/84505.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Este documento inclui o relatório de estágio em farmácia comunitária, realizado na Farmácia António Lucas sob a orientação da Dr.ª Teresa Mónica Ferreira, o relatório de estágio em indústria farmacêutica, realizado nos Laboratórios BASI sob a orientação do Dr. Filipe Silva, e a monografia intitulada "Novas moléulas antienvelhecimento de aplicação tópica", realizado sob a orientação da Professora Doutora Maria Manuel Silva no âmbito do Mestrado Integrado em Ciências Farmacêuticas. O envel

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Wu, Yun Ru, and 吳韻茹. "Raspberry extract prevents chronological aging and photoaging : From cell to animal approach." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/26090449443236349911.

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Janjuha, Sharan Kaur. "Intrinsic and extrinsic factors underlying β-cell quiescence during development and aging". Doctoral thesis, 2018. https://tud.qucosa.de/id/qucosa%3A31958.

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Aging is a universal process that is accompanied by the loss of proliferative potential of cells. However, factors governing this age-dependent decline in proliferation remain largely undefined. The pancreatic β-cells of the islets of Langerhans serve as a unique model to explore the effect of cellular age on proliferation and function within the same organ. During early juvenile stage, the zebrafish islet is rapidly expanding and newly differentiated β-cells are added to the pool of older β-cells that were formed during embryogenesis. In this thesis, using accurate reporters for cell-cycle st

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Книги з теми "Extrinsic Aging And Photoaging"

S, Rigel Darrell, ed. Photoaging. Marcel Dekker, 2004.

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Dover, Jeffrey S., Darrell S. Rigel, Robert A. Weiss, and Henry W. Lim. Photoaging. Taylor & Francis Group, 2004.

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Dover, Jeffrey S., Darrell S. Rigel, Robert A. Weiss, and Henry W. Lim. Photoaging. Taylor & Francis Group, 2004.

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(Editor), Darrell S. Rigel, Robert A. Weiss (Editor), Henry W. Lim (Editor), and Jeffrey S. Dover (Editor), eds. Photoaging (Basic and Clinical Dermatology, 29). Informa Healthcare, 2004.

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Graham, Emanuel. Skin Aging and Photoaging: Physiology, Clinical Aspects and Emerging Therapies. Nova Science Publishers, Incorporated, 2015.

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Частини книг з теми "Extrinsic Aging And Photoaging"

Lee, Won-Soo. "Hair Photoaging." In Aging Hair. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02636-2_13.

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Rittié, Laure, Gary J. Fisher, and John J. Voorhees. "Aging and Photoaging of the Skin." In Therapy of Skin Diseases. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-78814-0_60.

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Marionnet, Claire, Christine Duval, and Françoise Bernerd. "New Insights in Photoaging Process Revealed by In Vitro Reconstructed Skin Models." In Textbook of Aging Skin. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47398-6_163.

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Marionnet, Claire, Christine Duval, and Françoise Bernerd. "New Insights in Photoaging Process Revealed by In Vitro Reconstructed Skin Models." In Textbook of Aging Skin. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27814-3_163-1.

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Helmbold, Peter. "Basophilic (Actinic) Degeneration of the Dermis: An Easy Histological Scoring Approach in Dermal Photoaging." In Textbook of Aging Skin. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-89656-2_3.

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Pons, Alexandre, Maria Nikolantonaki, Valérie Lavigne, Kentaro Shinoda, Denis Dubourdieu, and Philippe Darriet. "New Insights into Intrinsic and Extrinsic Factors Triggering Premature Aging in White Wines." In ACS Symposium Series. American Chemical Society, 2015. http://dx.doi.org/10.1021/bk-2015-1203.ch015.

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Aparecida Sales de Oliveira Pinto, Claudineia, Tércio Elyan Azevedo Martins, Renata Miliani Martinez, Thamires Batello Freire, Maria Valéria Robles Velasco, and André Rolim Baby. "Vitamin E in Human Skin: Functionality and Topical Products." In Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98336.

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Vitamins are part of the antioxidant system of human skin, and are detectable in different layers, so the topical application can be an alternative to maintain the functionality of the system. The capacity of the antioxidant gradient of keratinocytes is associated with attenuation of the action of related free radicals in both esthetics and health. These problems arise from extrinsic aging and are related to the risk of cancer. Vitamin E has been proven to have antioxidant and moisturizing properties in the skin and can protect against the damage of UVB radiation, with emphasis on the reductio

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Yin, Rui. "Skin aging and photoaging." In Skin Photoaging. Morgan & Claypool Publishers, 2014. http://dx.doi.org/10.1088/978-1-6270-5455-3ch1.

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Тези доповідей конференцій з теми "Extrinsic Aging And Photoaging"

Tian, Wei Dong, Robert Gillies, and Nikiforos Kollias. "An Endogenous Dermal Fluorescence Band that may Serve as a Quantitative Marker of Aging and Photoaging." In Biomedical Optical Spectroscopy and Diagnostics. OSA, 1998. http://dx.doi.org/10.1364/bosd.1998.btua6.

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Segovia-Fernandez, Jeronimo, Ernest Ting-Ta Yen, Javier Rojas, Thu Tran, Mahmud Chowdhury, and Peter Smeys. "An Analytical Model to Predict Extrinsic Aging in BAW Resonators." In 2020 Joint Conference of the IEEE International Frequency Control Symposium and International Symposium on Applications of Ferroelectrics (IFCS-ISAF). IEEE, 2020. http://dx.doi.org/10.1109/ifcs-isaf41089.2020.9234907.

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Troshin, Pavel. "Revealing intrinsic and extrinsic photochemical aging pathways in organic absorber molecules." In nanoGe Spring Meeting 2022. Fundació Scito, 2022. http://dx.doi.org/10.29363/nanoge.nsm.2022.261.

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Dams, Susanne D., Moniek de Liefde, Tom Nuijs, Cees W. Oomens, and Frank P. Baaijens. "Repeated Heat Shocks Enhance Procollagen III Expression in Dermal Fibroblasts." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-205435.

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Aging of the skin is a universal process. Well-known characteristics are the development of fine lines and wrinkles, but also changes in skin tone, skin texture, thickness and moisture content are aspects of aging [1,2]. The aging process can be divided into intrinsic aging, such as changes in e.g. dermal components like collagen, elastic fibers, glucosaminogycans and fibroblasts, and extrinsic aging, which is caused by external factors e.g. damage by UV-radiation [3]. Rejuvenation of the skin aims at reversing the intrinsic and extrinsic signs of skin aging and can be established in the epide

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Lizcano, Maricela, Muhammad Shafiq, Sukesh B. Myneni, Gian Carlo Montanari, and Tiffany S. Williams. "Electrical Endurance to Extrinsic Aging of Polyphenylsulfone-Boron Nitride Composite Insulation for Aeronautical Power Systems." In AIAA AVIATION FORUM AND ASCEND 2024. American Institute of Aeronautics and Astronautics, 2024. http://dx.doi.org/10.2514/6.2024-4040.

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García, Ana Ruiz de Molina, and Lydia Giménez-Llort. "Intrinsic (Genotype) and Extrinsic (Environment) Factors in the Temporal Patterns of Nest-Building Process: Effect of Forced Isolation in Old Female Mice with Normal and AD-Pathological Aging." In IECBS 2021. MDPI, 2021. http://dx.doi.org/10.3390/iecbs2021-10677.

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Giménez-Llort, Lydia, and Miguel Llauradó-Sánchez. "Intrinsic and Extrinsic Factors in the Bizarre Patterns Elicited in the Open-Field Test in Male and Female Mice with Normal and AD-Pathological Aging under Social or Isolated Housing Conditions." In International Electronic Conference on Brain Sciences. MDPI, 2022. http://dx.doi.org/10.3390/iecbs2022-13506.

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Yeger-McKeever, Meira, Alice H. Huang, Ashley F. Stein, and Robert L. Mauck. "Engineered MSC-Laden Cartilage Constructs are Sensitive to Inflammatory Cytokine-Mediated Degradation." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176186.

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Degeneration of cartilage resulting from trauma or disease processes is an increasingly prevalent problem in the aging population. Intrinsic repair of cartilage is limited and few methodologies exist, short of prosthetic replacement, for restoring damaged articular surfaces. These realities engender a need for new strategies for extrinsic repair. One strategy, tissue engineering, generates replacement cartilage composed of scaffolds and differentiated chondrocytes [1]. In addition to chondrocytes, recent work has demonstrated that mesenchymal stem cells (MSCs) isolated from bone marrow may be

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Звіти організацій з теми "Extrinsic Aging And Photoaging"

Salerno, Ivanna Laura, and Claudio Dachevsky. Evaluation of 80 mg/ml calcium hydroxyapatite in the treatment of nasolabial folds. Analysis of durability, safety, and efficacy at 12 months. Edited by María Fernanda Cristoforetti. Lugones Editorial, 2025. https://doi.org/10.47196/0596.

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Introduction: skin aging involves collagen fragmentation, which affects the extracellular matrix and accelerates deterioration. Photoaging, caused by ultraviolet radiation, motivates patients to seek corrective treatments. Calcium hydroxyapatite (CaHA) is a biocompatible filler that stimulates collagen production and provides safe and long-lasting results with a low complication rate. Correction of the nasolabial fold (NLF) is key to facial aesthetics, and CaHA has been shown to be effective in improving appearance and rejuvenating the face. Objectives: demonstrate the efficacy and safety of C

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Dachevsky, Claudio, and Marcelo Robles. Safety and efficacy study of cross-linked hyaluronic acid 30 mg/ml for facial filler. Edited by María Fernanda Cristoforetti. Lugones Editorial, 2025. https://doi.org/10.47196/0591.

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Introduction: aging is a multifactorial process that affects both the functionality and aesthetics of the body, including the skin, influenced by intrinsic (genetic) and extrinsic (environmental) factors. Fillers, especially those based on hyaluronic acid (HA), are the most preferred in aesthetic procedures due to their efficacy, safety, and ease of use. In the midface, the most visible signs of aging, such as wrinkles and furrows, are often treated with cross-linked HA (CHA), recognized worldwide for its ability to correct folds and restore volume. Its resorption depends on time and individua

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