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Дисертації з теми "F092"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Juszczak, Agata. "Assessment and translation of novel biomarkers for diagnosis of maturity onset diabetes of the young due to HNF1A variants." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:e5dcd952-f092-4269-bb9b-35bfd577a031.

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HNF1A-MODY is the most common form of monogenic diabetes, but due to low awareness among clinicians and limited availability of genetic testing in many countries, the majority of cases are misdiagnosed as type 1 or type 2 diabetes. In clinical practice, it is apparent that some young adults with non-autoimmune diabetes share several features of MODY and type 2 diabetes. Hence, I aimed to understand the range of genetic variation in HNF1A in this group and whether we could use biomarkers to help identify those with HNF1A alleles likely to be influencing their diabetes status. I performed HNF1A

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2

Hitchen, Joseph. "Understanding the growth and convective instability of mushy layers, with application to young sea ice." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:d52480a9-f092-43c0-aa43-9b6a12c13d36.

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Sea ice is salt-water ice which forms at the poles when the oceans solidify, and it plays a vital role in polar climate and ecosystems. In particular, the salt fluxes from growing sea ice are a major contributor to the cold halocline in the Arctic, and to the Arctic and Southern Ocean circulations more generally. Sea ice is not a pure solid - it has a microstructure of solid ice crystals and concentrated brine, known as a mushy layer. Segregation occurring during solidification means that the colder interstitial fluid closer to the ice surface also has a larger salinity than the warmer, freshe

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3

Badinger, Harald. "European Integration and the Future Institutions of Europe." WU Vienna University of Economics and Business, 2018. http://epub.wu.ac.at/6249/1/wp264.pdf.

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This article summarizes a talk, given at the conference From Bretton Woods to Berlaymont: Globalisation, Integration and the Future of Europe, organized by KOF Swiss Economic Institute and ETH Zurich from 22-23 March 2018. It highlights the complexity and multidimensional nature of the question about the future development of the European Union. It argues that there is a need for rebalancing subsidiarity and supranationality, but that the assignment of tasks and the "optimal" degree of centralization has to be judged on a case-by-case basis, differentiated by policy area. Moreover, it emphasiz

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4

Véliz, Carissa. "On privacy." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:afb31b0e-f022-48a6-b239-4c704cfd4484.

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This thesis concerns the ethics and political philosophy surrounding privacy. It investigates what privacy is, what is at stake in its loss, and how it relates to other rights and values. The first part sets the groundwork for the rest of the thesis. Chapter One delves into the origins of privacy. I argue that privacy is not a recent cultural product, but rather a need buried deep in our evolutionary and human history. The second part of the thesis is dedicated to conceptual issues. Chapter Two clarifies the relation between privacy and the public and private divide. I argue against the popula

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5

Glogowska, Margaret. "The effectiveness and acceptability of community speech and language therapy provision in pre-school children." Thesis, University of Bristol, 2000. http://hdl.handle.net/1983/5677e3b5-f098-4999-a41d-8fdaa47b7b54.

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6

Dawed, Adem Yesuf. "Genetic and non-genetic determinants of drug response in type 2 diabetes." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/b4c75bd1-f09f-48f1-8ff2-6b813b6d29b4.

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<b>Background</b>: Approximately 415 million people live with diabetes worldwide. Type 2 diabetes (T2D) accounts for 85%–95% of the cases. Despite the availability of several drugs, considerable interindividual variation in response to medications results in unnecessary treatment failure. In addition to non-genetic factors, genetic factors are thought to contribute to such variability. <b>Aim</b>: This thesis attempts to investigate genetic and non-genetic factors underlying the variability in response to commonly used drugs in T2D. <b>Methods</b>: We assessed drug response as efficacy and/or

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7

Bhatt, Samir. "Statistical analysis of natural selection in RNA virus populations." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:64341c38-f09e-48ed-84e8-7ab9f171a753.

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A key goal of modern evolutionary biology is the identification of genes or genome regions that have been targeted by natural selection. Methods for detecting natural selection utilise the information sampled in contemporary gene sequences and test for deviation from the null hypothesis of neutrality. One such method is the McDonald Kreitman test (MK test), which detects the the molecular 'footprint' left by natural selection by considering the frequency of observed mutations within the sampled population. In this thesis I investigate the applicability of the MK test to viral populations and d

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8

Lee, Anthony. "On auxiliary variables and many-core architectures in computational statistics." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:244040a7-f094-4d57-a78f-e154ed3b353c.

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Emerging many-core computer architectures provide an incentive for computational methods to exhibit specific types of parallelism. Our ability to perform inference in Bayesian statistics is often dependent upon our ability to approximate expectations of functions of random variables, for which Monte Carlo methodology provides a general purpose solution using a computer. This thesis is primarily concerned with exploring the gains that can be obtained by using many-core architectures to accelerate existing population-based Monte Carlo algorithms, as well as providing a novel general framework th

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9

Tan, Tiong Kit. "Development of viral vectors for passive immunisation against influenza." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:54fd7396-f09a-46e5-952e-95a1f5449326.

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Seasonal influenza is a major global health threat causing more than 500,000 deaths annually. Pandemic influenza can arise through antigenic shift, or when novel influenza strains escape from animal reservoirs, and can affect a large geographical area leading to a large number of deaths. Neither prior infection, nor current vaccines, provide lasting protection due to the rapid antigenic evolution of influenza virus. The discovery of broadly neutralising antibodies (bnAbs) against influenza has opened the possibility of passive immunisation, which could provide protection against multiple influ

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10

Noonan, Michael James. "The socio-ecological functions of fossoriality in a group-living carnivore, the European badger (meles meles)." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:69ea12af-f012-41ec-9359-6983cee8590a.

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This thesis examines the role played by den use in socio-ecology, especially in leveraging group formation (i.e., the Fossorial Benefits Hypothesis; FBH), using badgers as a model species. In particular, I benefit from recent technological developments, facilitating detailed measurements of activity, energetic expenditure, ranging behaviour, and underground localisation, enabling the examination of hitherto intractable facets of badger socio-ecology, allowing a comprehensive investigation. Group-living is theorised to evolve when the benefits of living with conspecifics outweigh the costs. Whi

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11

Blaavand, Jakob Lindblad. "The Dirac-Higgs bundle." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:6e081810-f042-4b3e-9f7c-9eee3c930c35.

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The Dirac-Higgs bundle is a vector bundle with a natural connection on the moduli space of stable Higgs bundles on a compact Riemann surface. It is a vector bundle of null-spaces of a Dirac-operator coupled to stable Higgs bundles. In this thesis, we study various aspects of this bundle and its natural connection. The Dirac-Higgs bundle is hyperholomorphic on the smooth hyperkähler moduli space of stable Higgs bundles. This property is a generalisation of the four-dimensional anti- self-duality equations to hyperkähler manifolds. One use of the Dirac-Higgs bundle is the construction of a Nah

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12

Birch, Ivan. "The kinematics of the subtalar joint during the contact phase of walking : a novel measurement strategy." Thesis, University of Brighton, 2006. https://research.brighton.ac.uk/en/studentTheses/b738ce7e-f042-4279-85e3-d722fe8947f0.

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Movement at the subtalar joint is believed to be a fundamental contributor to foot function during walking. The complex structure and movement, and inaccessibility of the joint have resulted in limited published data with which to substantiate or refute theories regarding its movement during walking. This study investigated the use of the CODA M PX30 three d imensional motion analysis system and a purpose designed marker placement model as a strategy for measuring the movement of the subtalar joint during the contact phase of walking. The in vitro reliability of the measurement strategy was te

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13

Sanditov, Bulat. "ICT revolution, globalization and informational lock-in." Inst. für Volkswirtschaftstheorie und -politik, WU Vienna University of Economics and Business, 2004. http://epub.wu.ac.at/1594/1/document.pdf.

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We examine a model of social learning in networks following the lines of Bala and Goyal (1998, 2001). As a model of agents' behaviour we have chosen the model of informational cascades of Bikhchandani et al (1992). Similarly to Bala and Goyal we find that the higher the 'degree of integration' within the society is, the more likely it is that conformity of actions will arise. However, unlike their results our model suggests that in the presence of informational externalities globalisation of informational flows, expressed in the increasing density of communication channels in a network, may dr

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14

Heise, Arne. "Theorie optimaler Lohnräume. Zur Lohnpolitik in der Europäischen Währungsunion." Inst. für Volkswirtschaftstheorie und -politik, WU Vienna University of Economics and Business, 2000. http://epub.wu.ac.at/1610/1/document.pdf.

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Wage policy and the structure of collective bargaining systems have been neglected in the political and economic discussions that centered around the European Monetary Union (EMU) to an amazing extent. Collective bargaining is one of the very few issues that have been explicitly excluded from the Maastricht treaty as subject of European regulation and only recently, wage policy under the conditions of a European Monetary Union has been considered at closer range. Yet, this has been done without putting the topic into a more general perspective. In this paper, I want to expose a 'theory of opti

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15

Crespo, Cuaresma Jesus, and Octavio Fernandez-Amador. "Business cycle convergence in EMU: A first look at the second moment." Elsevier, 2013. http://epub.wu.ac.at/4128/1/JIMF_TP.pdf.

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We analyse the dynamics of the standard deviation of demand and supply shocks as well as of the demand component of GDP across countries in the European Monetary Union (EMU). This analysis allows us to evaluate the patterns of cyclical comovement in EMU and compare them the cyclical performance of the new members of the EU and other OECD countries. We make use of sigma-convergence methods to identify synchronization patterns in business cycles. The Eurozone has converged to a stable lower level of dispersion across business cycles during the end of the 80s and the beginning of the 90s.

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16

Gobin, Damien. "Étude de problèmes de diffusion inverse à énergie fixée pour des variétés asymptotiquement hyperboliques." Nantes, 2016. http://archive.bu.univ-nantes.fr/pollux/show.action?id=19e4187d-f072-4f00-a81c-f636386c7d24.

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On étudie des problèmes de diffusion inverse à énergie fixée pour différents types de géométries ayant plus ou moins de symétries. On commence par obtenir un résultat de diffusion inverse local à énergie fixée pour l’équation de Dirac sans masse et sans charge sur des variétés asymptotiquement hyperboliques et à symétrie sphérique. Dans un second chapitre on s’intéresse aux trous noirs de type Reissner-Nordström-de Sitter qui sont des solutions à symétrie sphérique et électriquement chargées de l’équation d’Einstein. On obtient alors un résultat de diffusion inverse à énergie fixée pour l’équa

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17

Fink, Gerhard, and Nigel Holden. "Collective culture shock. Contrastive reactions to radical systemic change." Forschungsinstitut für Europafragen, WU Vienna University of Economics and Business, 2002. http://epub.wu.ac.at/802/1/document.pdf.

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Many countries are going through severe transitions as they move from one system of economic management to another, experiencing a traumatic state which we term collective culture shock. Taking a cue from psychology, we suggest that collective culture shock can be seen as comprising four components: integration, assimilation, separation, and marginalisation. The movement towards free market economic systems calls for complex institutional adjustments, but these seem very difficult for societies to introduce in a systematic way. In order to exemplify collective culture shock, we examine four co

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18

Isard, Olivia. "Étude des effets modulateurs de Propionibacterium acnes sur l'expression kératinocytaire d'hormones cutanéesÉvaluation in vitro de l'efficacité d'une molécule thérapeutique à visée anti-acnéique." Nantes, 2010. https://archive.bu.univ-nantes.fr/pollux/show/show?id=e7545efa-f099-4c7b-93ff-77cc192ca470.

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L'acné est une pathologie inflammatoire du follicule pilo-sébacé multifactorielle dont le développement se déroule suivant trois étapes : une stimulation des glandes sébacées aboutissant à une hyper séborrhée, une hyper prolifération associée à une différenciation et une adhésion kératinocytaire anormale conduisant à la formation de la lésion élémentaire de l'acné : le microcomédon, et enfin une phase inflammatoire dans laquelle la bactérie Propionibacterium acnes (P. Acnes) semble jouer un rôle primordial. L'axe CRH/CRH-R1 (corticotropin releasing hormone / corticotropin releasing hormone rec

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19

Tilley, Alice. "Academically successful Care Leavers : what has gone right?" Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/academically-successful-care-leavers-what-has-gone-right(6e4a8182-f098-4dff-b6bd-a107e2a1c7c2).html.

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This research used Q methodology to explore the viewpoints of undergraduate Care Leavers (n = 10) and corporate parents (n = 20) regarding what it is that enables children who have been Looked After to achieve a university education. In addition, this study sought out the chance to explore the views of Care Leavers and corporate parents in such a way that themes emerging from each could be compared and considered in the light of future practice implications. The published literature exploring attainment in children and young people who are Looked After provides ample evidence of under-attainme

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20

Hasnain, Sumaira. "The mucus barrier : immune defence against gastrointestinal nematodes." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/the-mucus-barrier-immune-defence-against-gastrointestinal-nematodes(783094c4-f032-4ba8-b4f7-cb30394688f4).html.

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Trichuriasis, caused by the intestinal nematode Trichuris, is a disease that affects up to a billion people worldwide. To date, most of our knowledge of this disease comes from the mouse model, Trichuris muris, which has been successfully used to dissect the immune-mediated effector mechanisms that elicit the expulsion of the nematode. Numerous studies have shown a temporal association between intestinal nematode expulsion and goblet cell hyperplasia; however their precise role in response to nematode infection remains elusive. Goblet cells found at mucosal surfaces secrete many constituent co

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21

Ayme, Jean-François. "A molecular pentafoil knot and related circular helicates." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/a-molecular-pentafoil-knot-and-related-circular-helicates(86d54c23-f082-46f5-abf9-e3ee66d78c43).html.

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Knots are being discovered with increasing frequency in both biological and synthetic macromolecules and have been fundamental topological targets for chemical synthesis for the past two decades. However, only few synthetic molecular knots have been prepared to date and their properties remain largely unexplored. This thesis reports the synthesis of the most complex non-DNA molecular knot prepared to date: the self-assembly of five bis-aldehyde and five bis-amine building blocks around five metal cations and one chloride anion forms a 160-atom-loop molecular pentafoil knot (five crossing point

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22

Colwell, Dhamma. "An investigation into problem-solving by adults in their everyday lives." Thesis, King's College London (University of London), 2006. https://kclpure.kcl.ac.uk/portal/en/theses/an-investigation-into-problemsolving-by-adults-in-their-everyday-lives(22e61d33-f0f2-4448-8cee-197900ca2cd5).html.

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23

Clarke, Alison Thora. "The other twin : a study of the plays of Wilkie Collins." Thesis, King's College London (University of London), 2005. https://kclpure.kcl.ac.uk/portal/en/theses/the-other-twin--a-study-of-the-plays-of-wilkie-collins(4bc3739a-f09d-48bd-8057-01a79a1d082c).html.

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24

Rahman, Tanzima. "True blues, blacks and in-betweens : urban regeneration in Moss Side, Manchester." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/true-blues-blacks-and-inbetweens-urban-regeneration-in-moss-side-manchester(e57218cf-f042-41b5-b622-b12b93f033c9).html.

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In this thesis I describe state directed transformation through urban regeneration policy in the context of Moss Side, Manchester in the North West of England. The thesis explores connections between the state project of urban regeneration and the lives of residents’ who were targeted by strategies. The thesis therefore moves from economic and political contexts that informed the policies of urban regeneration to how they were implemented and by whom, and then into the personal lives of residents in order to demonstrate connections between these. The latter half of the thesis focuses particula

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25

Moriarty, Catherine. "Exploring trust and the relational experiences of male clients within counselling for childhood sexual abuse." Thesis, University of Roehampton, 2017. https://pure.roehampton.ac.uk/portal/en/studentthesis/exploring-trust-and-the-relational-experiences-of-male-clients-within-counselling-for-childhood-sexual-abuse(311232f1-f097-460b-81f0-eed67d63e930).html.

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Among the many researched outcomes of childhood sexual abuse (‘CSA’), relational difficulties have been well documented. However, male CSA survivors may experience several outcomes that are unique to their gendered experience and yet remain largely under-represented in the literature. A gap was identified in the research around the experience of the male survivor in therapy for childhood sexual abuse, particularly where it relates to relationship building. Therefore the research aimed to explore this from the perspective of the survivors, with a focus on trust within the therapeutic relationsh

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26

Chapochnikov, Nikolai. "Modeling the biophysical mechanisms of sound encoding at inner hair cell ribbon synapses." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-000D-F092-3.

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27

Engebretson, Jess. "Sovereign Fictions: Self-Determination and the Literature of the Nigeria-Biafra War." Thesis, 2021. https://doi.org/10.7916/d8-yy53-f022.

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This dissertation explores questions of African literature and international law through the lens of the Nigeria-Biafra war (1967-1970). A defining trauma of modern Nigerian history, the war produced a rich and sustained vein of writing that stretches from the late 1960s through the present day, encompassing canonical Nigerian novels as well as a number of British and diasporic texts. Drawing on both literary and legal theory, I argue that this body of work mobilizes particular literary features—including narrative, analogy, allegory, and genre—to articulate both familiar and innovative logics

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28

McLaren, Andrew G. "Ibn A‘tham's History: Transmission and Translation in Islamicate Written Culture, 290-873/902-1468." Thesis, 2021. https://doi.org/10.7916/d8-j0mq-f097.

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This dissertation is a study of the composition and reception of two chronicles written in Arabic in the first decades of the fourth century of the Islamic hijrī era (the tenth century of the current era). They were written by a little-known scholar usually called Abū Muḥammad Aḥmad ibn A‘tham al-Kūfī. Although no complete copy of the Arabic histories survives, the history was widely circulated in Persian. In other words, unlike most authors, Ibn A‘tham became somewhat more famous as his text circulated further. This work sets out to explain how this came to happen in two parts. The first pa

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29

Grabow, Carsten. "Impact of Complex Network Topology on Synchronization Dynamics." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F096-C.

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30

Wiesemann, Björn. "Diagnostik und Therapie des Polyzystischen Ovarsyndroms im Rahmen der klinischen Routineversorgung." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F002-5.

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31

Dießelberg, Catharina. "Activin A und Follistatin bei bakteriellen Infektionen - Der Einfluss von Activin A auf Mikrogliazellen in vitro und der Einfluss von Follistatin auf den Verlauf einer E. coli-K1-Sepsis im Mausmodell." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F012-1.

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32

Mundt, Birgit. "Vergleich der laryngoskopischen Intubation versus Intubation über die Intubationslarynxmaske an Patienten." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F029-F.

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33

Morick, Joachim. "Kinetik von Atom-Transfer Radikalischen Polymerisationen bis zu hohen Drücken." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F052-2.

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34

Aksoy, Eren Erdal. "Semantic analysis of image sequences using computer vision methods." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F072-B.

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35

Krieger, Nina. "Development of the readout for the IBL Upgrade Project of the ATLAS Pixel Detector." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F095-E.

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36

Knorr, Inga. "Mechanische Eigenschaften kristallin-amorpher Schichtpakete." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F099-6.

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37

Lenk, Benjamin. "Photo-magnonics in two-dimensional antidot lattices." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F098-8.

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38

Roos, Burkhard. "In-situ Zugversuche an einkristallinen Gold-Nanodrähten im TEM." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F094-0.

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39

Roe, Adam. "Measurement of the Top Quark Pair Production Cross Section and Simultaneous Extraction of the W Heavy Flavor Fraction at √s = 7 TeV with the ATLAS Detector at the LHC." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F082-7.

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40

Stetter, Frank Olav. "Bursting dynamics and topological structure of in vitro neuronal networks." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F091-5.

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41

Cadamuro, Daniela. "A Characterization Theorem for Local Operators in Factorizing Scattering Models." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F097-A.

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42

Yuan, Li. "Die abstrakte Gestaltung von Sicherheiten als elementarer Ausdruck der Privatautonomie." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F09A-4.

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43

Thomä, Jörg. "Kleine und mittlere Unternehmen mit Besonderheiten? – Beiträge zur Mittelstandsforschung an den Beispielen von Innovation und Konjunktur." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F09C-F.

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44

Wiesenfarth, Manuel. "Estimation and Inference in Special Nonparametric Models with Applications to Topics in Development Economics." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F09E-B.

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45

Klann, Nils-Hendrik. "Risk, Conflict and Challenges in the Context of Emerging Economies." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F09F-9.

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46

Ohinata, Ren. "Three Essays on Application of Semiparametric Regression: Partially Linear Mixed Effects Model and Index Model." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0A2-0.

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47

Platzmann, Florian Peter. "Methods to improve the sample quality of macromolecular complexes for structure determination by 3D Electron Cryo-Microscopy." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0B2-C.

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48

Dobrev, Plamen. "Protonation patterns in reduced and oxidized form of electron transfer proteins." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0C2-8.

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49

Hoischen, Nadine. "Einfluss von körperlichem Training auf verschiedene Aspekte der Lebensqualität bei Patienten mit diastolischer Herzinsuffizienz-Ergebnisse der prospektiven, randomisierten und kontrollierten Study Ex-DHF-P." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-000D-F0E2-F.

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50

Evangelakou, Despoina. "Z →ττ Cross Section Measurement and ττ Mass Reconstruction with the ATLAS Detector at the LHC". Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F090-7.

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