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Статті в журналах з теми "Fast dispersing tablet"

Автор: Grafiati

Опубліковано: 7 червня 2025

Оновлено: 2 серпня 2025

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1

Kumar Bhasin, Rakesh, Nirika Bhasin, and Pradip Kumar Ghosh. "Advances in Formulation of Orally Disintegrating Dosage Forms: A Review Article." Indo Global Journal of Pharmaceutical Sciences 01, no. 04 (2011): 328–53. http://dx.doi.org/10.35652/igjps.2011.33.

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Анотація:

Oral disintegrating tablets are solid dosage form containing medicinal substances which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue The products are designed to disintegrate or dissolve rapidly on contact with saliva, thus eliminating the need for chewing the tablet, swallowing an intact tablet, or taking the tablet with water. ODT is general form of nomenclature for tablets that disintegrate rapidly or instantly in the oral cavity. Other alias are Quick Dissolve, Rapid Dissolve, Rapid Disintegrating, Fast Disintegrating, Fast Melt, Flash Melt and Mou

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2

Jayaramu, Rajamma Abburu, Sateesha Shivally Boregowda, Addanki Rahul Deva Varma, and Chandan Kalegowda. "Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics." Brazilian Journal of Pharmaceutical Sciences 50, no. 4 (2014): 956–63. http://dx.doi.org/10.1590/s1984-82502014000400031.

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Анотація:

Formulation of FDT (fast dispersing tablets) of nebivolol was optimized and evaluated using simplex lattice design (SLD). The influence of type and concentration of three disintegrants viz.,Ac-Di-Sol, Primojel and Polyplasdone XL on hardness, friability and disintegration time of tablet was studied. Response surface plot and the polynomial equations were used to evaluate influence of polymer on the tablet properties. Results were statistically analyzed using ANOVA, and a p < 0.05 was considered statistically significant. Results reveal that fibrous integrity and optimal degree of substituti

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3

Abdul Qadir, Bhavana Singh, Deepika Joshi, and Nidhi Semwal. "Fast dissolving tablet: An updated review." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 052–59. http://dx.doi.org/10.30574/wjbphs.2022.11.3.0135.

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Анотація:

Improved patient management and patient tracking are essential to the development of an oral drug delivery system that remains a popular drug delivery route despite various maladies. Fast-dispersing pills (FDTs) have found growing demand over the past decade, and the field has become a fast-growing area in the pharmaceutical industry. The popularity and usefulness of the construction has led to the development of many FDT technologies. These are ways to make the tablet dissolve faster and spill in the mouth for five seconds without chewing and the need for beneficial water especially for child

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4

Abdul, Qadir, Singh Bhavana, Joshi Deepika, and Semwal Nidhi. "Fast dissolving tablet: An updated review." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 052–59. https://doi.org/10.5281/zenodo.7181372.

Повний текст джерела

Анотація:

Improved patient management and patient tracking are essential to the development of an oral drug delivery system that remains a popular drug delivery route despite various maladies. Fast-dispersing pills (FDTs) have found growing demand over the past decade, and the field has become a fast-growing area in the pharmaceutical industry. The popularity and usefulness of the construction has led to the development of many FDT technologies. These are ways to make the tablet dissolve faster and spill in the mouth for five seconds without chewing and the need for beneficial water especially for child

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5

Jain, P., A. Mishra, and A. Pathak. "PREPARATION & EVALUATION OF ORODISPERSIBLE TABLET CONTAINING ASPIRIN BY SUBLIMATION METHOD." INDIAN DRUGS 52, no. 12 (2015): 60–62. http://dx.doi.org/10.53879/id.52.12.10465.

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Анотація:

Orodispersible tablets are uncoated tablets which when taken into the mouth, get easily dispersed within 3 min before swallowing. they are also known as orally disintegrating tablets, mouth-dissolving tablets, rapid dissolving tablets fast-disintegrating tablets, fast-dissolving tablets. In this work, sublimation process was used to prepare orodispersible tablets of aspirin by formulating various batches using different concentration of sodium starch glycolate, camphor and cross povidone. An effort was made by using two modes, first, to increase water uptake for the fast dispersion by creating

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6

Philip, Christine, Shahnaz Usman, Muhammad Akram, and Quamrul Islam. "Formulation development, optimization, and evaluation of fast-dispersing tablets of cefixime trihydrate for pediatric use." Pharmacia 72 (May 7, 2025): 1–16. https://doi.org/10.3897/pharmacia.72.e144228.

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Анотація:

The proposed study aimed to formulate and optimize the design of a fast-dispersing tablet (FDT) of cefixime trihydrate (dispersed in a teaspoon of water) tailored for pediatric patients (0–12 years). To assess the percentage concentration of the cefixime in the formulated tablets, the HPLC method was validated and established linearity, r² = 0.9998 in the range of 20–0.078 µg/mL. The preformulation study was carried out. Crospovidone (X1), croscarmellose sodium (X2), and sodium starch glycolate (X3) were selected as key independent variables, and their impact was executed on friability and dis

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7

Philip, Christine, Shahnaz Usman, Muhammad Akram, and Quamrul Islam. "Formulation development, optimization, and evaluation of fast-dispersing tablets of cefixime trihydrate for pediatric use." Pharmacia 72 (May 7, 2025): 1–16. https://doi.org/10.3897/pharmacia.72.e144228.

Повний текст джерела

Анотація:

The proposed study aimed to formulate and optimize the design of a fast-dispersing tablet (FDT) of cefixime trihydrate (dispersed in a teaspoon of water) tailored for pediatric patients (0–12 years). To assess the percentage concentration of the cefixime in the formulated tablets, the HPLC method was validated and established linearity, r² = 0.9998 in the range of 20–0.078 µg/mL. The preformulation study was carried out. Crospovidone (X1), croscarmellose sodium (X2), and sodium starch glycolate (X3) were selected as key independent variables, and their impact was executed on friability and dis

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8

Pabari, Ritesh M., Claire McDermott, James Barlow, and Zebunnissa Ramtoola. "Stability of an Alternative Extemporaneous Captopril Fast-Dispersing Tablet Formulation Versus an Extemporaneous Oral Liquid Formulation." Clinical Therapeutics 34, no. 11 (2012): 2221–29. http://dx.doi.org/10.1016/j.clinthera.2012.10.005.

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9

Bhide, Prashant, and Reeshwa Nachinolkar. "FORMULATION DEVELOPMENT AND CHARACTERISATION OF MECLIZINE HYDROCHLORIDE FAST DISSOLVING TABLETS USING SOLID DISPERSION TECHNIQUE." International Journal of Applied Pharmaceutics 10, no. 4 (2018): 141. http://dx.doi.org/10.22159/ijap.2018v10i4.26493.

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Анотація:

Objective: The aim of the present investigation was to design and evaluate fast dissolving tablet (FDT) for the oral delivery containing solid dispersion of meclizine (MCZ) hydrochloride, an antiemetic drug.Methods: The solubility of meclizine was increased by preparing solid dispersions using mannitol as a carrier by fusion method. The prepared solid dispersion, was subjected for in vitro drug release, percent practical yield, drug content, infrared spectroscopy (IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM). Optimized solid dispersion was incorporated to pr

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10

Dr., G. Nagaraju, Sirisha V., Ramakrishna Kavati, and Hareesh Dara Dr. "FORMULATION AND EVALUATION OF DEXIBUPROFEN FAST DISINTEGRATING TABLETS WITH NATURAL SUPER DISINTEGRANTS." Journal of Pharma Research 8, no. 12 (2019): 744–50. https://doi.org/10.5281/zenodo.14233228.

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Анотація:

<strong>Abstract</strong> <strong>I</strong>n this present research work, an attempt was made to develop solid dispersions for the enhancement of solubility, dissolution and bioavailability of Dexibuprofen and also to find the effect of natural super disintegrants in the development of quickly disintegrating tablets.Solid dispersions were prepared by solvent evaporation method using PEG 20,000as carrier in different ratios. The optimized solid dispersions were prepared in the form of quick disintegrating tablets using different natural super disintegrants in different concentrations. The prepa

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11

Manish, Kumar Gupta, Pallavi, and Sen Manish Gupta Priya. "SOLUBILITY ENHANCEMENT OF POORLY WATERSOLUBLE DRUGS USING SOLID DISPERSION METHOD A REVIEW." International Journal of Current Pharmaceutical Review and Research 13, no. 3 (2021): 20–27. https://doi.org/10.5281/zenodo.12667110.

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Анотація:

Solid dispersions have attracted considerable interest as an efficient means of improving thedissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Up to40% of new chemical entities discovered by the pharmaceutical industry today are poorlysoluble or lipophilic compounds. Solid dispersions of poorly water-soluble drugs with watersoluble carriers reduce the incidence of these problems and enhanced dissolution. Soliddispersion is one of the most promising approaches for solubility enhancement. The termsolid dispersion refers to a group of solid products consisti

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12

Das, Pratik Swarup, Sushma Verma, and Puja Saha. "FAST DISSOLVING TABLET USING SOLID DISPERSION TECHNIQUE: A REVIEW." International Journal of Current Pharmaceutical Research 9, no. 6 (2017): 1. http://dx.doi.org/10.22159/ijcpr.2017v9i6.23435.

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Анотація:

Fast dissolving tablets are also called as mouth-dissolving tablets, melt-in mouth tablets, orodispersible tablets, quick dissolving etc. Fast dissolving tablets are those when put on tongue disintegrate instantaneously releasing the drug, which dissolve or disperses in the saliva. The faster the drug dissolved into solution, quicker the absorption and onset of clinical effect. Oral routes of drug administration have wide acceptance up to 50-60% of total dosage forms. Fast dissolving tablet containing solid dispersion was developed to improve the dissolution of drug and stability of solid disp

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13

Dev, Asish, Shravan Kumar Yadav, S. K. Kar, Smitapadma Mohanty, and Om Shelke. "Formulation and Characterization of Aceclofenac Mouth Dissolving Tablet by QbD." Journal of Drug Delivery and Therapeutics 9, no. 5 (2019): 43–50. http://dx.doi.org/10.22270/jddt.v9i5.3538.

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Анотація:

The purpose of this study was to develop fast dissolving tablets of Aceclofenac using different concentration of super disintegrants. Fast dissolving tablets of Aceclofenac were prepared by dry granulation technique using croscarmellose sodium together with avicel ph as superdisintegrants. The porous granules were then compressed in to tablets by direct compression technique. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and dispersion time. All the formulations showed low weight variation with dispersion time less than 90 seconds and rapid

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14

Coutinho, Ana Luisa, Asmita Adhikari, and James Polli. "10122 Development of an In Vitro in Vivo Correlation of Itraconazole Spray-Dried Dispersion Tablets." Journal of Clinical and Translational Science 5, s1 (2021): 96–97. http://dx.doi.org/10.1017/cts.2021.649.

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Анотація:

ABSTRACT IMPACT: As the number of poorly water-soluble drugs in development increases, our research will expand on the science behind improving drug solubility and absorption and ensuring that promising poorly-water solubility drugs do not fail drug development. OBJECTIVES/GOALS: Spray-dried dispersion (SDD) tablet formulation is an approach to increase oral drug solubility and absorption. Methods to predict SDD performance in humans are poorly developed. We aim to develop an in vivo in vitro correlation (IVIVC) between in vitro dissolution and in vivo absorption of itraconazole SDD tablets. M

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15

Mohammadi, Hafsa, Hemanath Kumar V, Roshan S, and Bhikshapathi D. V. R. N. "Development and Evaluation of Fast Disintegrating Tablets of Lornoxicam Solid Dispersions." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 4 (2019): 4585–92. http://dx.doi.org/10.37285/ijpsn.2019.12.4.4.

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Анотація:

 Lornoxicam is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class. It belongs to BCS class II substance with low solubility and high permeability. The aim of current research is to formulate solid dispersion incorporated Fast disintegrating tablets of Lornoxicam to enhance the dissolution rate and aqueous solubility and to enable faster onset of action. Solid dispersions are prepared with polymers like Kolliwax GMS, Soluplus and HPMC in three different ratios 1:1:1, 1:2:1 and 1:3:1. Formulations were characterized for drug content studies, drug release studies, and drug-po

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16

Khan, MD Abdul Aali, M. S. Sudheesh, and Rajesh Singh Pawar. "Formulation Development and Evaluation of Oro-Dispersible Tablets Based On Solid Dispersion of Cimetidine." Journal of Drug Delivery and Therapeutics 12, no. 6-S (2022): 42–46. http://dx.doi.org/10.22270/jddt.v12i6-s.5696.

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Анотація:

The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained. The objective of present study was to f

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17

Atneriya, Umesh K., Dharmendra Solanki, Komal Tikariya, and Arpit Gawshinde. "Development of fast release tablet of talinolol using fourth generation carrier of solid dispersion technique." Journal of Pharmaceutical and Biological Sciences 11, no. 1 (2023): 35–42. http://dx.doi.org/10.18231/j.jpbs.2023.007.

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Talinolol is a beta1-selective adreno receptor antagonist well known for its Cardio protective and antihypertensive activity. Talinolol is a beta blocker. In biopharmaceutical classification system the drugs which come under class II are characterized by more membrane permeability, less dissolution rate. Talinolol is a poor aqueous solubility drug leads to poor bioavailability. So, the aimed of this study was to develop immediate release tablet of talinolol by solid dispersions technique using poloxamer 407 as a carrier. Poloxamer 407 is a hydrophilic synthetic block copolymer widely used as a

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18

C., Haranath* T. Srikanth M. Suresh Krishna G. Chaithanya Barghav C. Mahesh Reddy. "FORMULATION AND INVITRO EVALUATION OF FAST DISINTEGRATING TABLETS OF AN ANTI-INFLAMMATORY DRUG." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 10790–99. https://doi.org/10.5281/zenodo.3229226.

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Анотація:

<em>Oral disintegrating tablets are defined as the tablets that disperse or disintegrates in less than one minute in the mouth prior to being swallowed, which results in the rapid dissolution and absorption of the active pharmaceutical ingredient contained in the tablet, providing rapid onset of action. Aceclofenac is a poorly water-soluble drug. The solubility of the drug was enhanced by solid dispersion technique using mannitol as the carrier. In the present study, 9 formulations were developed by using different super disintegrants like cross povidone, sodium starchglycolate and cross carme

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19

Adinarayanareddy, Pagadala, Dr J. N. Suresh Kumar, Routhu Nikhileshwar, Varri VenkataSatya Abhinaya, Doppalapudi Ramya, and Vemugadda Pavan Kumar. "Formulation and Evaluation of Fast Disintegrating Tablet of Solid Dispersion of Rifaximin- A Research." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 698–710. https://doi.org/10.35629/4494-1002698710.

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Анотація:

The aim of the present study was to formulate and evaluate fast disintegrating tablets of solid dispersions of Rifaximin. The solid dispersions of Rifaximin were prepared using PEG 6000 and PVP K30 in ratios of 1:1, 1:2, and 1:3 by the solvent evaporation method. These solid dispersions were then analyzed using Fourier Transform Infrared Spectroscopy(FTIR) there no drug an polymer interaction. The results showed that the solid dispersions had a better dissolution profile compared to the pure drug, with Formulation FD3 demonstrating the highest drug release of 96.6% in 40 minutes. Therefore, FD

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20

Saini, Seema, and Rajeev Garg. "Design expert assisted mathematical optimization of solubility and study of fast disintegrating tablets of Lercanidipine Hydrochloride." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 172–80. http://dx.doi.org/10.22270/jddt.v9i1-s.2406.

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Анотація:

90% of drugs being researched today, posses poor solubility setback which inturn renders the drug with slower rate of absorption from the buccal route; hence dissolution is the rate limiting step for such lipophilic drugs. So, there is a need to keep a check on the dissolution profile of these drugs to ensure maximum therapeutic utilization. The dissolution rate therefore becomes a primary factor which governs the rate and extent of its absorption. Enormous work is being performed in the field of enhancement of solubility and dissolution behaviour of such drugs. Advancements and innovations ha

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21

Rajan, Hardikar S., Shaikh N. M. Mustaqeem, Ansari D. M. Akbar, and Peerzade M. Yasir. "Development of Vaginal Tablet of Clotrimazole Prepared by Applying the Concept of Percolatio Threshold." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1459–64. http://dx.doi.org/10.25258/ijddt.13.4.52.

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Анотація:

Clotrimazole is the drug of choice in the treatment of vulvovaginal candidiasis and belongs to biopharmaceutical classification system (BCS) class IIb. Therefore, it should be presented in appropriate form adopting a suitable formulation approach to ensure its fast and complete release in the vagina. Solid dispersion of clotrimazole was prepared using microcrystalline cellulose as a carrier material after confirming their miscibility into each other by the ‘melting point depression’ method. Vaginal tablets of the solid dispersion of clotrimazole were prepared by direct compression using co-pro

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22

Singh, Gurpreet, Jayesh Dwivedi, Jeyabalan Govindasamy, Naresh Kalra, and Rajesh Sharma. "Formulation of Mouth Dissolving Tablets Using Solid Dispersion Technique: A Review." Indian Journal of Pharmaceutical and Biological Research 6, no. 03 (2018): 66–72. http://dx.doi.org/10.30750/ijpbr.6.3.11.

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Анотація:

Mouth-dissolving tablets are also called as fast disintegrating tablets, melt-in mouth tablets, orodispersible tablets, quick dissolving etc. Mouth dissolving tablets are those when put on tongue disintegrate rapidly thereby releasing the drug, which dissolve or disperses in the saliva. The faster the drug dissolved into solution, quick will be the absorption and onset of clinical effect. Mouth dissolving tablet containing solid dispersion was developed to improve the solubility of drug and stability of solid dispersion. Such tablets are disintegrate and/or dissolve rapidly in the saliva witho

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23

Reddy, P. Srikanth, V. Alagarsamy, P. Subhash Chandra Bose, V. Sruthi, and D. Saritha. "DESIGN AND CHARACTERIZATION OF NATEGLINIDE ORAL DISPERSIBLE TABLETS BY SOLID DISPERSION TECHNIQUE." International Journal of Research in Ayurveda and Pharmacy 13, no. 04 (2022): 72–77. http://dx.doi.org/10.7897/2277-4343.130491.

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An ideal dosage regimen in the drug therapy of any disease is the one which immediately attains the desired therapeutic concentration of drug in plasma and maintains it constant for the entire duration of treatment. The main objective of the present work is to investigate the possibility of obtaining an immediate release tablet of Nateglinide with improved dissolution using the Solid dispersion technique. Solid dispersions preparations containing different weight ratios of Nateglinide in PEG6000 (1:1, 1:3, 1:5) were prepared by the melting method and characterized for drug content, phase solub

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24

Alami-Milani, Mitra, Sara Salatin, Elaheh Nasiri, and Mitra Jelvehgari. "Preparation and optimization of fast disintegrating tablets of isosorbide dinitrate using lyophilization method for oral drug delivery." Therapeutic Delivery 12, no. 7 (2021): 523–38. http://dx.doi.org/10.4155/tde-2020-0127.

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Анотація:

Background: Orally disintegrating tablets rapidly disintegrate in saliva and then swallowed without the need for water. Materials & methods: The orally disintegrating tablets were prepared by freeze-drying of an aqueous dispersion of isosorbide dinitrate containing a matrix former (gelatin), a cryoprotectant (mannitol), a plasticizer (glycerin) and a dissolution enhancer (Tween/polyethylene glycol). Results: Results demonstrated that the selected formulation, Ft9, disintegrated within 1 min and showed faster dissolution rate compared with the commercial tablet. Conclusion: Having a fast di

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25

Preethi, G. B., Sayan Banerjee, H. N. Shivakumar, and M. Ravi Kumar. "FORMULATION OF FAST-DISSOLVING TABLETS OF DOXAZOSIN MESYLATE DRUG BY DIRECT COMPRESSION METHOD." International Journal of Applied Pharmaceutics 9, no. 5 (2017): 22. http://dx.doi.org/10.22159/ijap.2017v9i5.18168.

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Анотація:

Objective: The rationale of the current research work was to formulate and evaluate fast-dissolving tablets of doxazosin mesylate with minimum disintegration time and improved dissolution efficiency using solid dispersion method.Methods: Solid dispersions of doxazosin mesylate and polyethylene glycol 8000 in different ratios were prepared using the kneading method. The prepared solid dispersions were subjected to drug interaction and dissolution studies to select the effective solid dispersion for the formulation of fast-dissolving tablets. Fast dissolving tablets containing drug-polyethylene

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26

Agarwal, Shivendra, Raghvendra Misra, and Girendra Kumar Gautam. "FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF TASTE MASKING MOUTH DISSOLVING TABLET OF LEVOCETIRIZINE DIHYDROCHLORIDE." International Journal of Pharma Professional’s Research (IJPPR) 14, no. 1 (2023): 47–58. http://dx.doi.org/10.48165/ijppronline.2023.14118.

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Анотація:

Levocetirizine dihydrochloride is a selective, long acting peripheral H1receptor antagonist. Allergic rhinitis is a symptomatic disorder of the nose induced by inflammation mediated by immunoglobulin E (IgE) in the membrane lining the nose after allergen exposure. Thus formulating Levocetirizine into an mouth dissolving tablet dosage form would provide fast relief. The Levocetirizine is bitter in taste so the Kyron T-114 (ion exchange resin) was used to mask the taste and to formulate an mouth dissolving tablet dosage form using drug resin complex. The tablets were evaluated for the drug conte

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27

Acharya, A., G. B. K. Kumar, P. Goudanavar, and K. Dhakal. "Various approaches to enhance the dissolution of Lornoxicam fast dissolving tablets prepared by using different categories of superdisintegrants: A comparative study." Journal of Manmohan Memorial Institute of Health Sciences 4, no. 1 (2018): 86–102. http://dx.doi.org/10.3126/jmmihs.v4i1.21147.

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Анотація:

Background: Recent developments in fast dissolving tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets.The main objective of the present study is to formulate fast dissolving tablet of Lornoxicam by direct compression method.Methods: Guar gum and crospovidone were used as natural and synthetic superdisintegrants respectively. Fast dissolving tablet of Lornoxicam were prepared by direct compression technique using three different approaches; superdisintegrant addition, sublimation, and solid dispersion.Results: IR and DSC studies s

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28

Vijaya Laxmi, M., Srinu Naik, Shashikumar Yadav, and G. Vijaya Charan. "Effect of Surfactants on Lansoprazole Solid Dispersions: A Pathway to Improved Dissolution and Development of Fast Disintegrating Tablets." Journal of Neonatal Surgery 14, no. 6S (2025): 810–19. https://doi.org/10.52783/jns.v14.2334.

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Анотація:

Aim: The study aimed to enhance the solubility and dissolution rate of Lansoprazole, a poorly water-soluble drug, using binary and ternary solid dispersions (SDs) with polyethylene glycol (PEG) 6000 and surfactants such as Tween 80 and sodium dodecyl sulfate (SDS). Additionally, fast-disintegrating tablets (FDTs) were developed using optimized solid dispersions to improve drug release. Methods: Binary and ternary solid dispersions of Lansoprazole were prepared using the solvent-melt method. Physical mixtures were also formulated for comparison. These formulations were characterized through aqu

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29

Islam, Nayyer, Muhammad Irfan, Nasir Abbas, et al. "Enhancement of solubility and dissolution rate of ebastine fast-disintegrating tablets by solid dispersion method." Tropical Journal of Pharmaceutical Research 19, no. 9 (2020): 1797–805. http://dx.doi.org/10.4314/tjpr.v19i9.1.

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Анотація:

Purpose: To investigate the efficiency of different solubilizing agents in improving solubility as well as dissolution rate of ebastine (a BCS class II drug) by incorporating prepared solid dispersion into fast disintegrating tablets.Method: The solubility of ebastine was determined in distilled water, lipids and solubilizing agents. Subsequently, the binary solid dispersions were prepared by kneading method using varying weight ratios of ebastine and solubilizing agents. The solid dispersions were then incorporated into fast disintegrating tablets (SD-FDT). Central composite rotatable design

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Shahidulla, S. M., Mohib Khan, and K. N. Jayaveera. "Formulation of fast disintegrating domperidone tablets using Plantago ovata mucilage by 3² full factorial design." International Current Pharmaceutical Journal 4, no. 8 (2015): 415–19. http://dx.doi.org/10.3329/icpj.v4i8.24023.

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Анотація:

The present work was carried out to study the disintegrant property of plantago ovata mucilage. The objective of the work was to formulate Fast disintegrating tablets of Domperidon with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata mucilage (2-10% w/w) was used as natural superdisintegrant and microcrystalline cellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in

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Gupta, Ashish, Juhi Bhadoria, and G. N. Darwhekar. "Formulation and Evaluation of Orodispersible Tablet of Atorvastatin Calcium by Using Hibiscus rosa sinesis Mucilage as Natural Superdisintegrant." Journal of Drug Delivery and Therapeutics 9, no. 6 (2019): 90–94. http://dx.doi.org/10.22270/jddt.v9i6.3677.

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Анотація:

Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. Oral bioavailability of Atorvastatin Calcium is low (14%) and shows extensive intestinal clearance and first-pass metabolism, which is the main cause for the low systemic availability. In the present work, orodispersible tablets of Atorvastatin calcium were prepared by direct compression method using Hibiscus rosa sinesis mucilage as natural superdisintegrant with a view to enhance patient compliance a

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Satpute, Mangesh Machhindranath, and Nagesh Shivaji Tour. "Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate." Brazilian Journal of Pharmaceutical Sciences 49, no. 4 (2013): 783–92. http://dx.doi.org/10.1590/s1984-82502013000400018.

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Анотація:

The demand for fast dissolving tablets has been growing during the last decade, especially for elderly and children who have swallowing difficulties. In the present work, fast dissolving tablets of metoprolol tartrate, were prepared using sodium starch glycolate, sodium croscarmellose and crospovidone as superdisintegrants, by the direct compression method. The tablets prepared were evaluated for various parameters including weight variation, hardness, friability, in vitro dispersion time, drug-polymer interaction, drug content water absorption ratio, wetting time, in vitro drug release, FTIR

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Jaiswal, Sourabh, and Abhishek Kanugo. "Design and Development of Fast-dissolving Tablets of Apixaban using Single Coprocessed Excipient." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 2 (2024): 7217–26. http://dx.doi.org/10.37285/ijpsn.2024.17.2.2.

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Анотація:

Background: Apixaban is administered orally as an anticoagulant action and minimizes the chances of strokes and systemic embolism. The conventional film-coated tablet showed less bioavailability due to its minimal solubility in the gastrointestinal tract. Rationale: The goal of designing the current analysis is to prepare a prompt release tablet using a single Coprocessed excipient which minimizes multistep processing, time, and cost effectiveness. Methods: The prompt release tablets of Apixaban were developed by direct compression technique using multifunctional material like Prosolve ODT G2

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NAGPAL, MANJU, LOVELEEN KAUR, JANITA CHANDER, and PRATIMA SHARMA. "Dissolution Enhancement of Domperidone Fast Disintegrating Tablet Using Modified Locust Bean Gum by Solid Dispersion Technique." Journal of Pharmaceutical Technology, Research and Management 4, no. 1 (2016): 1–11. http://dx.doi.org/10.15415/jptrm.2016.41001.

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Bigogno, Eduarda Rocha, Luciano Soares, Matheus Henrique Ruela Mews, et al. "It is Possible to Achieve Tablets With Good Tabletability From Solid Dispersions – The Case of the High Dose Drug Gemfibrozil." Current Drug Delivery 17 (October 23, 2020): e18100. https://doi.org/10.2174/1567201817666201023121948.

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Анотація:

Abstract: Background: Solid Dispersions (SDs) have been extensively used to increase the dissolution of poorly water-soluble drugs. However, there are few studies exploring SDs properties that must be considered during tablet development, like tabletability. Poorly water-soluble drugs with poor compression properties and high therapeutic doses, like gemfibrozil, are an additional challenge in the production of SDs-based tablets. Objective: This study evaluates the applicability of SDs to improve both tabletability and dissolution rate of gemfibrozil. A SD-based tablet formulation was also prop

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Shahidulla, SM, and Tayyaba Jeelani. "Formulation and In-Vitro Evaluation of Taste Masked Fast Disintegrating Tablets of Labetalol Hydrochloride by Wet Granulation Technique." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 442–49. http://dx.doi.org/10.22270/jddt.v9i4-a.3506.

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Анотація:

Labetalol Hydrochloride is a β-blocker generally indicated for the treatment of hypertension, and it is extensively metabolized due to the hepatic metabolism. In the present work, an attempt was made to mask the taste by Solid Dispersion technique, with a formulation into Fast Disintegrating dosage form, using superdisintegrants such as Cross carmellose sodium (CCS), crospovidone (CP) and sodium starch glycolate (SSG). The complexes of Labetalol hydrochloride with HP-β-CD (1:3 ratio) were prepared by Co-precipitation method. Using the drug HP-β-CD complex, Fast Disintegrating tablets were prep

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Thakur, Diksha, and Rambabu Sharma. "Solid dispersion a novel approach for enhancement of solubility and dissolution rate: a review." Indian Journal of Pharmaceutical and Biological Research 7, no. 03 (2019): 05–11. http://dx.doi.org/10.30750/ijpbr.7.3.2.

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Анотація:

The oral route is the most preferred route for the administration of various drugs because it is the most convenient and safest route for drug delivery. The researcher develops a recently fast dissolving tablet (FDT). This improved patient compliance and convenience. FDTs are defining as the solid dosage form, which disintegrates in saliva without the need for water. Solid dispersions attract considerable interest by increasing the dissolution rate and also enhance the bioavailability of poor water-soluble drugs. Pre-gastric absorption avoids first-pass hepatic metabolism, which increases the

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Kanathe, Pooja, Ruchi Jain, Nilesh Jain, and Surendra Kumar Jain. "Formulation and Evaluation of Orodispersible Tablet of Fluvastatin Sodium." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 42–47. http://dx.doi.org/10.22270/jddt.v11i1.4498.

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Анотація:

The purpose of this research work is to formulate and evaluate the Orodispersible tablet of Fluvastatin Sodium to enhance the bioavailability and effectiveness of the drug. The objectives of the drug work were to formulate and evaluate Orodispersible tablets of Fluvastatin Sodium, having adequate mechanical strength, rapid disintegration, and fast action. Precompression parameters like angle of repose, bulk density, tapped density, compressibility index & post-compression parameters like wetting time, water absorption ratio, in-vitro disintegration, and in-vitro dispersion time were studie

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Irfan Sohail, Noman Ahmad, Muhammad Majid, Waqas Ahmad Nasir, Shan Malik, and Tuseef Tahir. "Formulation and in vitro evaluation of mouth dissolving tablets of levosulpiride." Journal of Contemporary Pharmacy 2, no. 2 (2019): 49–53. http://dx.doi.org/10.56770/jcp201809.

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Анотація:

Objective: The objective of this study was to formulate and optimize a mouth dissolving formulation of levosulpiride. Method: Levosulpiride mouth dissolving tablet having D2-dopamine receptor antagonistic activity were made by direct compression using microcrystalline cellulose, mannitol, povidone and a disintegrant sodium starch glycolate. Thus, formulating levosulpiride into amouth dissolving dosage form would provide fast relief. Results: The tablets were evaluated for weight variation, drug content, content uniformity, hardness, friability, in-vitro disintegration time and in-vitro drug re

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Dhakal, Bhawana, Jaybir Kumar Thakur, Reema Kumari Mahato, et al. "Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters." Scientific World Journal 2022 (May 19, 2022): 1–13. http://dx.doi.org/10.1155/2022/9618344.

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Анотація:

Ebastine is a long-acting, nonsedating, second-generation antihistaminic drug that prevents histamine action, mainly in immediate hypersensitivity. This project was aimed to formulate and characterize orodispersible tablets of ebastine, utilizing different proportions of three disintegrants, namely crospovidone, sodium starch glycolate, and coprocessed superdisintegrant. Initially, fifteen trial batches of ebastine orodispersible tablets were outlined using the central composite design of Minitab software. The tablets were formulated by the direct compression method. The compressed tablets wer

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Triboandas, Hetvi, Kendal Pitt, Mariana Bezerra, Delphine Ach-Hubert, and Walkiria Schlindwein. "Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools." Pharmaceutics 14, no. 11 (2022): 2398. http://dx.doi.org/10.3390/pharmaceutics14112398.

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Анотація:

BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon® VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ’s poor solubility. A novel strategy for tablet formulations using five inorganic salts was investigated (KCl, NaCl, KBr, KHCO3 and KH2PO4). These kosmotopric salts are thought to compete for water hydration near the polymer chain, hence, preventing polymer gelation and, therefore, facilitating disintegration and dissolution. Out of all the

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Nandhini M, Voleti Vijaya Kumar, Suganya T, et al. "Formulation, development and evaluation of fast disintegrating tablet of dapsone by using natural super disintegrates." International Journal of Pharmaceutical Chemistry and Analysis 11, no. 3 (2024): 239–44. http://dx.doi.org/10.18231/j.ijpca.2024.034.

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Анотація:

The needof the fast-disintegrating tablets ever increasing day by day during the last decade. In this current research study, the effect of the natural super disintegrating agents in the Dapsone fast disintegrating tablets was compared. The natural super disintegrating agents were characterized for different physico chemical methods like Loss on drying, moisture content and Ash values.Dapsone was selected as a model drug, where the dapsone has low bioavailability due to this reason, dapsone solid dispersions were developed and the same was used to formulate the tablets. The formation of the so

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Kamalapurkar, Krishnamurthy A., Mahesh P. Chitali, and Revansidh R. Pujari. "Formulation development and characterization of fast dissolving tablets of oxcarbazepine." Indian Journal of Pharmaceutical and Biological Research 3, no. 01 (2015): 11–17. http://dx.doi.org/10.30750/ijpbr.3.1.3.

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Анотація:

The objective of this study was formulation development and evaluation of Oxcarbazepine Fast Dissolving Tablets (FDTs) prepared by sublimation technique where different sublimating agents like camphor and menthol were used with L-HPC and crospovidone as a superdisintegrants. Oxcarbazepine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. Each sublimating agent was used in concentration of 10-20 mg per tablet. Tablets were first prepared and then kept in hot air oven for sublimation. The prepared FDTs were evaluated for weight variation, thickness, drug content,

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Gandhi, Lavika, and Md Semimul Akhtar. "Formulation and Characterization of Mouth Dissolving Tablet of Antiepileptic Drug using Natural Superdisintegrants." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 673–78. http://dx.doi.org/10.22270/jddt.v9i3-s.2950.

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MDTs is regarding as a good candidates for the patients with persistent nausea, who are traveling, or who have little or no access to water. The objective of present research work was to prepare and evaluate the mouth dissolving tablet of Lacosamide using Super disintegrants like Guar Gum, and other excipients like Microcrystalline Cellulose and Mannitol in different concentrations by Direct Compression method. Lacosamide has been shown to be an effective antiepileptic agent appropriate for the epilepsy patients. Effect of different formulation variables i.e. amount of polymer and type of poly

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C, Soujanya, Ravi Prakash P., Lakshmi Satya B., and Ashwini M. "Formulation and Evaluation of Oral Disintegrating Tablets of Aripiprazole Solid Dispersions by Sublimation Technique." International Journal of Drug Design and Discovery 6, no. 4 (2025): 1500–1505. https://doi.org/10.37285/ijddd.6.4.5.

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Анотація:

The present research work was to formulate and evaluate fast disintegrating tablets by sublimation technique using camphor and sodium bicarbonate as sublimating agents in combination with various superdisintegrants. This method is used to sublimate the tablet which in turn increases its porosity, there by fast rate of disintegration and thus bioavailability is achieved. In the present work the drug selected was Aripiprazole used in the treatment of schizophrenia. It is preferable to administer in the form of oral disintegrating tablets used for depressive episodes, acute manic episodes associa

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Rajesh, Asija, Gupta Avinash, and Kumar Fardoliya Jitendra. "Development of Dispersible Aceclofenac Tablet Using Adsorbent." Pharmaceutical and Chemical Journal 2, no. 1 (2015): 31–40. https://doi.org/10.5281/zenodo.13692292.

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Анотація:

It has been reported that about 40% of the compounds being developed by the pharmaceutical industries are poorly water soluble. The limiting factor to the <em>in vivo </em>performance of poorly water soluble drugs after oral administration their inadequate ability to be wetted by and dissolved into the fluid in the gastrointestinal (GI) tract. Therefore, increasing the dissolution rate of poorly water soluble drugs is an important and significant challenge to pharmaceutical scientists in order to maximize absorption. Aceclofenac is a nonsteroidal anti-inflamatory drug (NSAID), used for rheumat

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A.B., Gangurde Mohammed Awais* V. A. Bairagi Abdurrahman Sanaurrehman Karishma Rajashri. "FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF FAST DISSOLVING TABLETS OF RAMIPRIL SOLID DISPERSION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 08 (2018): 8409–16. https://doi.org/10.5281/zenodo.1411687.

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Анотація:

<em>Ramipril is a prodrug belonging to the angiotensin</em>-<em>converting enzyme </em>(<em>ACE</em>) <em>inhibitor which is metabolized to Ramiprilat in the liver and, to a lesser extent, kidneys</em>.<em>The poor solubility and wett</em> <em>ability of Ramipril leads to poor dissolution and variations in bioavailability</em>.<em>Solid dispersion of Ramipril was prepared using Hydroxy propyl β</em>- <em>cyclodextrin to improve water solubility</em>. <em>Prepared solid dispersion was shown improved solubility in water of 97</em>.<em>5 µg</em>/<em>ml</em>. <em>Fast dissolving tablets

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Shirsand, SB, RT Gumate, V. Jonathan, and Shailashri. "Novel Co-processed Spray Dried Super Disintegrants Designing of Fast Dissolving Tablets Using." Dhaka University Journal of Pharmaceutical Sciences 15, no. 2 (2017): 167–72. http://dx.doi.org/10.3329/dujps.v15i2.30933.

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Анотація:

In the present study, novel co-processed superdisintegrants were developed by spray drying method using microcrystalline cellulose and mannitol in different ratios (1:1, 1:2 and 1:3) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carrs index and Hausners ratio in comparison with physical mixture of superdisintegrants. The angle of repose of the developed excipients was found to be < 30o, Carrs index in the range of 9-15 % and Hausners ratio in the range of 1.12-1.16. Fast dissolving tablets of glibenclamide were prepared

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Rahul, Kumar Roop Singh Panthi Rohit Kumar Dhakad Rohit Kumar Manoj Kumari More. "Formulation And Evolution of Fast Dissolving Tablet Containing Nanoparticle Poorly Water-Soluble Drug." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3020–23. https://doi.org/10.5281/zenodo.15458341.

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Анотація:

In recent decades, a range of pharmaceutical research has been done to develop new dosage forms. Among the dosage forms designed to aid ease of treatment, the rapid disintegrating tablet (RDT) is one of the most commonly deployed commercial goods. Formulating these compounds as pure drug nanoparticles is one of the newer drug-delivery strategies applied to this class of molecules. Nanoparticle dispersions are stable and have a mean diameter of less than 1 micron. The formulations consist of water, drug, and one or more generally regarded as safe excipients. These formulations offer a chance to

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Ravi, V. Patel, Y. Ansari Gazala, and O. Bhangale Jitendra. "Development and Characterization of Solid Dispersion of Rasagilline Mesylate for Improvement of Dissolution Rate Using Hydrophilic Carriers." International Journal of Current Science Research and Review 06, no. 06 (2023): 3223–39. https://doi.org/10.5281/zenodo.8019827.

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Анотація:

<strong>ABSTRACT: </strong>The aim of present study was to improve the solubility of Rasagilline mesylate, an Atypical Antipsychotic agent which is BCS Class III drug and thus has very low solubility and hence very poor bioavailability owing to less absorption. Moreover Rasagilline mesylate has a bitter taste. Thus in the present study an attempt was made to taste mask the bitter taste of drug and improve oral bioavailability of drug by formulating the drug into solid dispersion and then formulate the solid dispersions into Fast Dissolving Tablets. Solid Dispersions of Rasagilline mesylate wer

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