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Статті в журналах з теми "Ferric ascorbate"

Автор: Grafiati

Опубліковано: 7 червня 2025

Оновлено: 2 серпня 2025

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1

Divya, Sri Keerthika B. Priyanka B. P. Harith Mahesh Gomasa Dr. Swathi Boddupally*. "Study On Efficacy and Compliance of Oral Supplements with Ferric Pyrophosphate and Ferrous Ascorbate in Iron Deficiency Anaemia During Pregnancy." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1080–86. https://doi.org/10.5281/zenodo.15354355.

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Background: Iron deficiency anaemia in pregnancy is a nutritional disorder characterized by insufficient iron levels, leading to reduced haemoglobin production. This condition poses significant risks to both maternal and fatal health including increased chances of preterm birth, low birth, weight and maternal morbidity. It often results from inadequate dietary intake, poor iron absorption, or increased iron requirements during pregnancy. Early diagnosis and appropriate management through iron supplementation and dietary adjustments are crucial to mitigate adverse outcomes and promote healthy p

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2

Tamilselvan, T., Nissy Nelson Shanet, Ann Thomas Senorita, KM Shabla, and Sathyan Sneha. "Assessment of Efficacy and Cost-Effectiveness of Oral and IV Iron Therapy in Chronic Kidney Disease." Journal of Drug Delivery and Therapeutics 13, no. 11 (2023): 107–10. http://dx.doi.org/10.22270/jddt.v13i11.6306.

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Introduction: Long-term iron therapy for anemia in chronic kidney disease patients is creating an economic burden and discontinuation of the treatment. Objective: The purpose of this study was to assess the cost-effectiveness and efficacy of oral and intravenous iron therapy and iron therapy. Methods: the patients were distributed into group 1 and group 2 and were administered with oral and intravenous iron therapy respectively. Baseline hemoglobin and packed cell volume were recorded and subsequently monitored in the next follow-up visit to assess the efficacy of the iron therapy. Results: Am

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3

Petrarulo, M., M. Marangella, O. Bianco, A. Marchesini, and F. Linari. "Preventing ascorbate interference in ion-chromatographic determinations of urinary oxalate: four methods compared." Clinical Chemistry 36, no. 9 (1990): 1642–45. http://dx.doi.org/10.1093/clinchem/36.9.1642.

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Abstract In an attempt to decrease ascorbate interference on the ion-chromatographic determination of urinary oxalate, we compared the effectiveness of four different methods for ascorbate elimination by analyzing a representative urine pool supplemented with successive ascorbate additions. Two of the methods--treatment with ferric ions or boric acid--have been described elsewhere; treatments with nitrites or ascorbate oxidase (EC 1.10.3.3) are investigated here as possible alternatives. Consideration of the main features, advantages, and drawbacks of the four procedures leads us to conclude t

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4

McKie, Andrew T. "The role of Dcytb in iron metabolism: an update." Biochemical Society Transactions 36, no. 6 (2008): 1239–41. http://dx.doi.org/10.1042/bst0361239.

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Dcytb (duodenal cytochrome b) is an iron-regulated ferric reductase highly expressed in duodenal enterocytes. Its location and strong regulation by iron has indicated it plays an important role in iron absorption. Expression of Dcytb in cells (Caco-2 and MDCK) was found to increase both ferric reductase activity and stimulate uptake of 59Fe. An additional increase in cupric reductase activity was found in MDCK (Madin–Darby canine kidney) cells expressing Dcytb. Expression and purification of Dcytb in insect cells reveals that Dcytb is a di-haem protein and that the haems are reducible by ascor

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5

Inamdar, Kalpana V., Keddy G. Raghavan, and Dinkar S. Pradhan. "Five treatment procedures evaluated for the elimination of ascorbate interference in the enzymatic determination of urinary oxalate." Clinical Chemistry 37, no. 6 (1991): 864–68. http://dx.doi.org/10.1093/clinchem/37.6.864.

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Abstract We evaluated the efficacies of five treatment procedures for eliminating ascorbate interference in the enzymatic determination of urinary oxalate. Aliquots of urine samples, containing different amounts of added ascorbate and oxalate, were individually subjected to ferric chloride, sodium nitrite, sodium periodate, charcoal, or ascorbate oxidase treatment to eliminate ascorbate interference. Oxalate contents of the urine samples were then determined by a banana oxalate oxidase-horseradish peroxidase-linked assay with 3-methyl-2-benzothiazolinone hydrazone and 3-(dimethylamino)benzoic

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6

Kulkarni, Prashant, and Sasikumar Menon. "A randomized open-label study to compare iron content in the blood of healthy subjects treated with Tasiron tablets containing ferric di-phosphate as compared to tablets containing ferrous ascorbate." International Journal of Advances in Medicine 10, no. 12 (2023): 836–39. http://dx.doi.org/10.18203/2349-3933.ijam20233567.

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Iron deficiency anemia (IDA) frequently affects reproductive-age women, pregnant women, and children of growing age, particularly in developing countries like India. Traditional oral iron supplementation has various side effects, and therefore, liposomal technology has been introduced. This study compared serum iron levels in healthy adult female subjects treated with Tasiron tablets containing 30 mg (elemental iron) of micronized liposomal ferric di-phosphate, with those administered with tablets containing 100 mg (elemental iron) of ferrous ascorbate, over 15 days. The test group (n=7) recei

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7

Atanasova, Bisera D., Andy CY Li, Ingvar Bjarnason, Kamen N. Tzatchev, and Robert J. Simpson. "Duodenal ascorbate and ferric reductase in human iron deficiency." American Journal of Clinical Nutrition 81, no. 1 (2005): 130–33. http://dx.doi.org/10.1093/ajcn/81.1.130.

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8

Lane, Darius J. R., Stephen R. Robinson, Hania Czerwinska, Glenda M. Bishop, and Alfons Lawen. "Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron." Biochemical Journal 432, no. 1 (2010): 123–32. http://dx.doi.org/10.1042/bj20101317.

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Astrocytes are central to iron and ascorbate homoeostasis within the brain. Although NTBI (non-transferrin-bound iron) may be a major form of iron imported by astrocytes in vivo, the mechanisms responsible remain unclear. The present study examines NTBI uptake by cultured astrocytes and the involvement of ascorbate and DMT1 (divalent metal transporter 1). We demonstrate that iron accumulation by ascorbate-deficient astrocytes is insensitive to both membrane-impermeant Fe(II) chelators and to the addition of the ferroxidase caeruloplasmin. However, when astrocytes are ascorbate-replete, as occu

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9

Piotrowsky, Alban, Markus Burkard, Katharina Hammerschmidt, et al. "Analysis of High-Dose Ascorbate-Induced Cytotoxicity in Human Glioblastoma Cells and the Role of Dehydroascorbic Acid and Iron." Antioxidants 13, no. 9 (2024): 1095. http://dx.doi.org/10.3390/antiox13091095.

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Several studies have demonstrated, both in vitro and in animal models, the anti-tumor efficacy of high-dose ascorbate treatment against a variety of tumor entities, including glioblastoma, the most common and aggressive primary malignant brain tumor. The aim of this study was to investigate the effects of high-dose ascorbate as well as dehydroascorbic acid on human glioblastoma cell lines and to evaluate different treatment conditions for the combined administration of ascorbate with magnesium (Mg2+) and iron (Fe3+). Intracellular levels of reactive oxygen species and the induction of cell dea

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10

Amin, Shabana, Shazia Nisar, and S. Arif Kazmi. "Stopped-Flow Kinetic Study of Reduction of Ferric Maltol Complex by Ascorbate." JOURNAL OF ADVANCES IN CHEMISTRY 12, no. 4 (2016): 4338–41. http://dx.doi.org/10.24297/jac.v12i4.2174.

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Stopped-flow kinetic investigation of reduction of Fe(III)-maltol complex is reported. The rates are dependent on pH in a complex way. On one hand at low pH there is a predominance of Fe(III)(maltol)2 which is easier to reduce compared to Fe(III) (maltol)3 which is more resistant to reduction. On the other hand ascorbate is a stronger reducing agent at higher pH. The rates are also found to be inversely dependent on the concentration of free ligand. These observations are explained by the following rate law:Rate = ((k0 +k1[H+])k2 [Asc-]/ (k-1[HMal] + k2[Asc-])) + k3 [Asc-] ) [FeIII(Mal)3] Here

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11

Abosharaf, Hamed A., Yuki Sakamoto, Aliaa M. Radwan, et al. "Functional Assembly of Caenorhabditis elegans Cytochrome b-2 (Cecytb-2) into Phospholipid Bilayer Nanodisc with Enhanced Iron Reductase Activity." Biomolecules 11, no. 1 (2021): 96. http://dx.doi.org/10.3390/biom11010096.

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Among seven homologs of cytochrome b561 in a model organism C. elegans, Cecytb-2 was confirmed to be expressed in digestive organs and was considered as a homolog of human Dcytb functioning as a ferric reductase. Cecytb-2 protein was expressed in Pichia pastoris cells, purified, and reconstituted into a phospholipid bilayer nanodisc. The reconstituted Cecytb-2 in nanodisc environments was extremely stable and more reducible with ascorbate than in a detergent-micelle state. We confirmed the ferric reductase activity of Cecytb-2 by analyzing the oxidation of ferrous heme upon addition of ferric

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12

Moumita, Hazra. "A Molecular Pharmacokinetic Study on the Comparative Pharmacological Response and Patient Adherence to Ferrous Ascorbate, Ferrous Sulphate, Ferrous Fumarate and Ferric Ammonium Citrate: An Analytical Evidence-Based Clinical Research." International Journal of Toxicological and Pharmacological Research 12, no. 3 (2022): 44–52. https://doi.org/10.5281/zenodo.12508727.

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<strong>Background: </strong>Anaemia is a global health concern, during adolescence, pregnancy and lactation, controlled by oral haematinics, like ferrous ascorbate, ferrous fumarate, ferrous sulphate and ferric ammonium citrate. <strong>Objectives: </strong>This analytical evidence-based clinical research was conducted for the molecular pharmacokinetic study on the comparative pharmacological response and patient adherence to ferrous ascorbate, ferrous sulphate, ferrous fumarate and ferric ammonium citrate, in tertiary patient healthcare hospitals. <strong>Materials and Me

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13

Gutteridge, John M. C. "Plasma ascorbate levels and inhibition of the antioxidant activity of caeruloplasmin." Clinical Science 81, no. 3 (1991): 413–17. http://dx.doi.org/10.1042/cs0810413.

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1. The copper-containing protein caeruloplasmin has several oxidase activities. 2. Its ability to catalyse the oxidation of ferrous ions to the ferric state (ferroxidase activity) makes it an important antioxidant in vivo. 3. Recent reports have suggested that oral supplementation with vitamin C can inhibit the oxidase activities of caeruloplasmin. 4. As expected, damage to DNA and membrane lipids was stimulated by mixtures of iron salt and ascorbate, and this damage could be inhibited by caeruloplasmin provided the molar ratio of ascorbate to caeruloplasmin was kept sufficiently low. 5. When

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14

Laulhère, J. P., A. M. Labouré, and J. F. Briat. "Photoreduction and incorporation of iron into ferritins." Biochemical Journal 269, no. 1 (1990): 79–84. http://dx.doi.org/10.1042/bj2690079.

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Pea seed ferritin is able to incorporate ferrous iron into the mineral core. Fe2+ may be formed by reduction of exogenous Fe3+ with ascorbate or by photoreduction by ferritin and by ferric citrate. In our experimental conditions the bulk of the photoreduction is carried out by ferritin, which is able to photoreduce its endogenous iron. Citrate does not enhance the photoreduction capacity of ferritin, and exogenous ferric citrate improves the yield of the reaction by about 30%. The mineral core of the ferritin is shown to photoreduce actively, and the protein shell does not participate directly

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15

Asati, Diksha, Arvind Kumar Yadav, and Sanjay Mandot. "Comparison between oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia." International Journal of Contemporary Pediatrics 8, no. 4 (2021): 694. http://dx.doi.org/10.18203/2349-3291.ijcp20211079.

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Background: Anemia is a global health issue. There is association of impaired cognition and iron deficiency anemia. Ferrous and ferric forms of oral iron preparations are available for the treatment of iron deficiency anemia. This study was conducted with an aim to compare the efficacy and safety of oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia.Methods: It was a prospective interventional study with 12 weeks of treatment protocols alternatively assigned to children diagnosed with iron deficiency anemia. Patients received either of two iron preparation use

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16

Jordan, I., and J. Kaplan. "The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity." Biochemical Journal 302, no. 3 (1994): 875–79. http://dx.doi.org/10.1042/bj3020875.

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Mammalian cells accumulate iron from ferric citrate or ferric nitrilotriacetate through the activity of a transferrin-independent iron transport system [Sturrock, Alexander, Lamb, Craven and Kaplan (1990) J. Biol. Chem. 265, 3139-3145]. The uptake system might recognize and transport ferric-anion complexes, or cells may reduce ferric iron at the surface and then transport ferrous iron. To distinguish between these possibilities we exposed cells to either [59Fe]ferric citrate or ferric [14C]citrate and determined whether accumulation of iron was accompanied by the obligatory accumulation of cit

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17

Wyckoff, Elizabeth E., Alexandra R. Mey, Andreas Leimbach, Carolyn F. Fisher, and Shelley M. Payne. "Characterization of Ferric and Ferrous Iron Transport Systems in Vibrio cholerae." Journal of Bacteriology 188, no. 18 (2006): 6515–23. http://dx.doi.org/10.1128/jb.00626-06.

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ABSTRACT Vibrio cholerae has multiple iron acquisition systems, including TonB-dependent transport of heme and of the catechol siderophore vibriobactin. Strains defective in both of these systems grow well in laboratory media and in the infant mouse intestine, indicating the presence of additional iron acquisition systems. Previously uncharacterized potential iron transport systems, including a homologue of the ferrous transporter Feo and a periplasmic binding protein-dependent ATP binding cassette (ABC) transport system, termed Fbp, were identified in the V. cholerae genome sequence. Clones e

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18

Atanasova, Bisera, Robert Simpson, Andy Li, Kamen Tzatchev, and Timothy Peters. "Duodenal mucosal and plasma ascorbate levels of patients with iron deficiency." Jugoslovenska medicinska biohemija 23, no. 3 (2004): 279–83. http://dx.doi.org/10.2298/jmh0403279a.

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Iron is a vital element for almost all living organisms. In mammals iron is taken by the intestinal epithelium, primarily in the duodenum. The initial step of absorption involves the reduction of ferric to ferrous iron both in gastric lumen and at the brush-border apical membrane. Reductase activity is increased by factors physiologically stimulating iron absorption, such as iron deficiency and chronic hypoxia. Ascorbic acid (Vitamin C) has long been known to enhance absorption of dietary iron in humans as shown by several nutritional/dietetic studies. This effect has been ascribed to lumenal

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19

Dunne, Jacqueline, Alexis Caron, Patrick Menu, et al. "Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo." Biochemical Journal 399, no. 3 (2006): 513–24. http://dx.doi.org/10.1042/bj20060341.

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Haemoglobin initiates free radical chemistry. In particular, the interactions of peroxides with the ferric (met) species of haemoglobin generate two strong oxidants: ferryl iron and a protein-bound free radical. We have studied the endogenous defences to this reactive chemistry in a rabbit model following 20% exchange transfusion with cell-free haemoglobin stabilized in tetrameric form [via cross-linking with bis-(3,5-dibromosalicyl)fumarate]. The transfusate contained 95% oxyhaemoglobin, 5% methaemoglobin and 25 μM free iron. EPR spectroscopy revealed that the free iron in the transfusate was

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20

Koshiishi, Ichiro, Yoshie Mamura, Ji Liu, and Toshio Imanari. "Evaluation of an acidic deproteinization for the measurement of ascorbate and dehydroascorbate in plasma samples." Clinical Chemistry 44, no. 4 (1998): 863–68. http://dx.doi.org/10.1093/clinchem/44.4.863.

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Abstract The most popular pretreatment method of plasma samples for the measurement of ascorbate (AsA) and dehydroascorbate (DHA) has been an acidic deproteinization via metaphosphoric acid or trichloroacetic acid. In general, DHA is absent in plasma samples prepared from human blood in a conventional manner. However, when these plasma samples were subjected to acidic deproteinization, DHA was detected in the acidified sample solutions. In the present study, we demonstrate that the oxidation of AsA to DHA in the solutions was promoted by at least two mechanisms, one involving catalysis by ferr

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21

Hazra, Moumita. "A study on the aspects of pharmacoepidemiology and pharmacohaemovigilance of ferrous ascorbate, ferrous fumarate, ferrous sulphate and ferric ammonium citrate, among the rural anaemic women, in the Indian spectrum." International Journal of Basic & Clinical Pharmacology 8, no. 12 (2019): 2751. http://dx.doi.org/10.18203/2319-2003.ijbcp20195291.

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Background: Anaemia is a global health concern, associated with increased maternal and perinatal mortality, preterm delivery, low birth weight, extreme fatigue and impaired immune system; and controlled by oral haematinics; with a rise in haemoglobin concentration. The objective was to examine the various aspects of pharmacoepidemiology and pharmacohaemovigilance of oral haematinics, among the anaemic women population, in rural India.Methods: This was a multi-centre, retrospective, observational and analytical study of the hospital medical records of 250 anaemic patients, who were allocated in

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22

Weber, Günther, Nicolaus von Wirén, and Heiko Hayen. "Investigation of ascorbate-mediated iron release from ferric phytosiderophores in the presence of nicotianamine." BioMetals 21, no. 5 (2008): 503–13. http://dx.doi.org/10.1007/s10534-008-9137-8.

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23

Trinder, Deborah, and Evan Morgan. "Mechanisms of ferric citrate uptake by human hepatoma cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 275, no. 2 (1998): G279—G286. http://dx.doi.org/10.1152/ajpgi.1998.275.2.g279.

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The mechanisms of uptake of non-transferrin-bound iron by human hepatoma cells (HuH7) were investigated using 59Fe-citrate and [14C]citrate. The amount of iron associated with the cells increased linearly with time, whereas citrate uptake reached a plateau after 45 min, resulting in a cellular accumulation of iron over citrate. The cells displayed high-affinity membrane binding sites for citrate with maximum binding of 118 ± 17 pmol citrate/mg protein and a dissociation constant of 21 ± 2 μM ( n = 3). Iron uptake was saturable with a maximum uptake rate of 1.95 ± 0.43 pmol ⋅ mg protein−1 ⋅ min

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24

Iqbal, Mohammad, Hassan Rezazadeh, Sabah Ansar та Mohammad Athar. "α-Tocopherol (vitamin-E) ameliorates ferric nitrilotriacetate (Fe-NTA)-dependent renal proliferative response and toxicity: diminution of oxidative stress". Human & Experimental Toxicology 17, № 3 (1998): 163–71. http://dx.doi.org/10.1177/096032719801700307.

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Ferric nitrilotriacetate (Fe-NTA) is a potent nephrotoxic agent. In this communication, we show the modulatory effect of DL-a-tocopherol (Vitamin-E) on ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative stress, toxicity and hyperproliferative response in rats. Fe-NTA-treatment enhances the susceptibility of renal microsomal membrane for iron-ascorbate-induced lipid peroxidation and hydrogen peroxide generation which are accompanied by a decrease in the activities of renal antioxidant enzymes, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase and deple

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25

Smith*, Brandon, and Lailiang Cheng. "Photoprotective Mechanisms of Grape Leaves (Vitis labrusca L. cv. Concord) in Relation to Iron Supply." HortScience 39, no. 4 (2004): 854A—854. http://dx.doi.org/10.21273/hortsci.39.4.854a.

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One-year-old `Concord' grapevines (Vitis labrusca L.) were fertigated twice weekly for 11 weeks with a complete nutrient solution containing 1, 10, 20, 50 or 100 μmol iron (Fe) from ferric ethylenediamine di (o-hydroxyphenylacetic) acid (Fe-EDDHA). Leaf total Fe content did not increase in response to Fe supply, however both “active” Fe (extracted with 2, 2'-dipyridyl) and chlorophyll (Chl) content increased as applied Fe increased. At the lowest active Fe level, leaf absorptance and maximum PSII efficiency (Fv/Fm) were slightly decreased, and non-photochemical quenching was significantly grea

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26

Ismayilova, G. H. "Effect of ferric iron oxide nanoparticles on ascorbate peroxidase activity in durum and bread wheat seedlings." Advanced Studies in Biology 15, no. 1 (2023): 47–54. http://dx.doi.org/10.12988/asb.2023.91621.

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27

Zhang, Xinling, Yuxing Liu, Weida Zhang, et al. "Salicylic Acid Treatment Ameliorates Postharvest Quality Deterioration in ‘France’ Prune (Prunus domestica L. ‘Ximei’) Fruit by Modulating the Antioxidant System." Foods 13, no. 18 (2024): 2871. http://dx.doi.org/10.3390/foods13182871.

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The potential of salicylic acid (SA) in delaying postharvest fruit senescence has been extensively documented; nevertheless, its effect on antioxidant activity and quality of ‘France’ prune fruit is largely unknown. The study investigated the effects of SA (0.5 mM) on postharvest quality deterioration of ‘France’ prune fruit. Results indicated that SA impeded the increase in respiration rate and weight loss, and mitigated the decrease of soluble solids content (SSC), titratable acidity (TA) content, firmness, and hue angle. SA sustained the ascorbate-glutathione cycle by inducing the productio

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28

ISMAILOVA, G. H., and I. V. AZIZOV. "EFFECT OF Fe2O3 AND Al2O3 NANOPARTICLES ON THE ANTIOXIDANT ENZYMES IN SEEDLINGS OF TRITICUM AESTIVUM L." SABRAO Journal of Breeding and Genetics 54, no. 3 (2022): 671–77. http://dx.doi.org/10.54910/sabrao2022.54.3.19.

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During their lifetime, plants are constantly exposed to varied environmental factors, which leads to an enhancement in the generation of reactive oxygen species (ROS), and the antioxidant system (AOS) that controls the level of ROS and protects the plant cells. The latest study considered the changes in the activity of several high molecular weight components of the AOS—ascorbate peroxidase (APO), catalase (CAT), and polyphenol oxidase (POL)—in two-week old seedlings of soft wheat (Triticum aestivum L.) cultivars under the influence of different (trivalent ferric oxide and aluminum oxide nanop

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29

Kisic, Bojana, Dijana Miric, Lepsa Zoric, Aleksandra Ilic, and Ilija Dragojevic. "Antioxidant Capacity of Lenses with Age-Related Cataract." Oxidative Medicine and Cellular Longevity 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/467130.

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The immediate cause of the occurrence of cataract is unknown, but oxidative damage and effects of reactive oxygen species are considered important in its etiopathogenesis. Our research was aimed at testing the nonenzyme antioxidant power of corticonuclear lens blocks, with different types and different maturity of age-related cataract. Clinical and biochemical researches were carried out in 101 patients with age-related cataract. In corticonuclear lens blocks of the patient, the concentration of nonprotein and total-SH groups and the concentration of total vitamin C and dehydroascorbic acid (D

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Ratliff, Melanie, Wenming Zhu, Rahul Deshmukh, Angela Wilks, and Igor Stojiljkovic. "Homologues of Neisserial Heme Oxygenase in Gram-Negative Bacteria: Degradation of Heme by the Product of thepigA Gene of Pseudomonas aeruginosa." Journal of Bacteriology 183, no. 21 (2001): 6394–403. http://dx.doi.org/10.1128/jb.183.21.6394-6403.2001.

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ABSTRACT The oxidative cleavage of heme to release iron is a mechanism by which some bacterial pathogens can utilize heme as an iron source. ThepigA gene of Pseudomonas aeruginosa is shown to encode a heme oxygenase protein, which was identified in the genome sequence by its significant homology (37%) with HemO ofNeisseria meningitidis. When the gene encoding the neisserial heme oxygenase, hemO, was replaced withpigA, we demonstrated that pigA could functionally replace hemO and allow for heme utilization by neisseriae. Furthermore, when pigA was disrupted by cassette mutagenesis in P. aerugin

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31

Gutteridge, John M. C. "Ferrous ions detected in cerebrospinal fluid by using bleomycin and DNA damage." Clinical Science 82, no. 3 (1992): 315–20. http://dx.doi.org/10.1042/cs0820315.

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1. During pathological states of iron-overload or oxidant stress, low-molecular-mass iron can become available within extracellular fluids. 2. This iron would be converted to the ferrous state were it not for the protective anti-oxidant protein caeruloplasmin. 3. The ferrous-ion-oxidizing activity of caeruloplasmin rapidly converts ferrous ions back to the less reactive ferric state so that they can bind to available binding sites on transferrin. 4. Cerebrospinal fluids, however, often appear to contain low-molecular-mass iron, high levels of ascorbate and low levels of ferroxidase activity wi

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32

JOSHI, A., PK PATRA, PK MISHRA, PK KHODIAR, and GK SAHU. "Phytochemical estimation and antimicrobial activity assessment of different solvent extracts of Tridax procumbens L." Journal of Medicinal and Aromatic Plant Sciences 45, no. 4 (2023): 123–32. http://dx.doi.org/10.62029/jmaps.v45i4.joshi.

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This study estimates the pharmacological properties of T. procumbens using qualitative and quantitative analysis of secondary metabolites, antioxidants, and antimicrobial activity analysis. Using standard methods, four aqueous extracts were prepared and screened for alkaloids, flavonoids, saponins, tannins, phenol, and ascorbic acid. The antioxidant profiling was undertaken with the support of 2, 2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical, ferric reducing antioxidant power (FRAP) and reducing power assay. The antimicrobial assay of crude fractions was conducted against human pathogen

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33

Rossman, Matthew J., Ryan S. Garten, H. Jonathan Groot, et al. "Ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 305, no. 10 (2013): R1163—R1170. http://dx.doi.org/10.1152/ajpregu.00360.2013.

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Chronic obstructive pulmonary disease (COPD) is associated with systemic oxidative stress and skeletal muscle dysfunction. The purpose of this study was to examine the impact of intravenous ascorbate administration (AO) on biological markers of antioxidant capacity and oxidative stress, and subsequently skeletal muscle function during dynamic, small muscle mass exercise in patients with COPD. Ten patients with spirometric evidence of COPD performed single-leg knee extensor (KE) trials matched for intensity and time (isotime) following intravenous ascorbate (2 g) or saline infusion (PL). Quadri

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34

Pranaya P та Akiladevi D. "Estimation of total Phenolic and ϑlavonoids content and Studies on antioxidant activity of different extracts of Olax scandens by FRAP assay". International Journal of Research in Pharmaceutical Sciences 11, № 3 (2020): 3367–71. http://dx.doi.org/10.26452/ijrps.v11i3.2472.

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Olax scandens Roxb. (family Olacaceae) available in throughout tropical India. The current study, aerial parts of different concentrates of Olax scandens was evaluated for its in-vitro antioxidant potential by FRAP assay taking ascorbic acid as the standard and estimation of total phenolic content and flavonoids content. The IC50 value was originated that methanolic concentrates of Olax scandens are more efficient in antioxidant activity by FRAP methods compared EA & PE concentrates. The methanolic concentrates of Olax scandens & ascorbate exhibited antioxidant potential possessing IC5

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35

Mammadli, G. H. "The activity of ascorbate peroxidase in seedlings of durum and soft wheat varieties under the influence of trivalent ferric oxides nanoparticles." International Journal of Scientific & Engineering Research 11, no. 8 (2020): 369–74. http://dx.doi.org/10.14299/ijser.2020.08.03.

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36

Hermes-Lima, Marcelo, Prem Ponka, and Herbert M. Schulman. "The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate." Biochimica et Biophysica Acta (BBA) - General Subjects 1523, no. 2-3 (2000): 154–60. http://dx.doi.org/10.1016/s0304-4165(00)00115-x.

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37

Shukla, Tarun, Atul Kumar Dwivedi, Reguram Arumugaperumal, Chien-Min Lin, San-Yuan Chen, and Hong-Cheu Lin. "Host-guest interaction of rotaxane assembly through selective detection of ferric ion: Insight into hemin sensing and switching with sodium ascorbate." Dyes and Pigments 131 (August 2016): 49–59. http://dx.doi.org/10.1016/j.dyepig.2016.03.049.

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38

Darshika Pathiraje and Akila Pradeepa Dalpathadu. "Enhancing color stability of raw chicken patties using instant tea: A comparative study of instant tea produced from low- and high-quality black tea." World Journal of Biology Pharmacy and Health Sciences 20, no. 2 (2024): 186–95. http://dx.doi.org/10.30574/wjbphs.2024.20.2.0844.

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This study evaluated the efficacy of instant tea powder made from low- and high-quality black tea on the color stability of raw chicken patties stored under refrigerated conditions. The phenolic content and antioxidant properties of the tea were assessed using in vitro assays. Results indicated that instant tea made from high-quality tea had a higher total phenolic content than that made from low-quality tea. Both teas from low- and high-quality raw materials demonstrated significant DPPH radical scavenging and ferric-reducing capacities, indicating their potential as effective natural antioxi

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39

Kanon, Alexander P., Caroline Giezenaar, Nicole C. Roy, et al. "Effects of Green and Gold Kiwifruit Varieties on Antioxidant Neuroprotective Potential in Pigs as a Model for Human Adults." Nutrients 16, no. 8 (2024): 1097. http://dx.doi.org/10.3390/nu16081097.

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Kiwifruit (KF) has shown neuroprotective potential in cell-based and rodent models by augmenting the capacity of endogenous antioxidant systems. This study aimed to determine whether KF consumption modulates the antioxidant capacity of plasma and brain tissue in growing pigs. Eighteen male pigs were divided equally into three groups: (1) bread, (2) bread + Actinidia deliciosa cv. ‘Hayward’ (green-fleshed), and (3) bread + A. chinensis cv. ‘Hort16A’ (yellow-fleshed). Following consumption of the diets for eight days, plasma and brain tissue (brain stem, corpus striatum, hippocampus, and prefron

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40

Mackler, B. P., and V. Herbert. "The effect of raw wheat bran, alfalfa meal and alpha-cellulose on iron ascorbate chelate and ferric chloride in three binding solutions." American Journal of Clinical Nutrition 42, no. 4 (1985): 618–28. http://dx.doi.org/10.1093/ajcn/42.4.618.

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41

Deters, Erin, and Stephanie L. Hansen. "44 Pre-transit vitamin C injection improves post-transit performance of beef steers." Journal of Animal Science 98, Supplement_3 (2020): 34. http://dx.doi.org/10.1093/jas/skaa054.061.

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Abstract This study sought to determine the effects of injectable vitamin C (VC), pre- or post-transit, on blood parameters and feedlot performance of beef steers. Seventy-two, Angus-cross steers were blocked by weight (356 ± 18 kg) and randomly assigned to intramuscular injection treatments (20 mL/steer): saline pre- and post-transit (CON), VC (Vet One; 250 mg sodium ascorbate/mL) pre-transit and saline post-transit (PRE), or saline pre-transit and VC post-transit (POST). Following pre-transit injections (d 0), steers were transported for ~18 h (1,675 km). Upon return (d 1), steers received p

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42

Smith, Brandon R., and Lailiang Cheng. "Photoprotective Mechanisms of `Concord' Grape Leaves in Relation to Iron Supply." Journal of the American Society for Horticultural Science 130, no. 3 (2005): 331–40. http://dx.doi.org/10.21273/jashs.130.3.331.

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The objective of this study was to quantify how photoprotective mechanisms in the leaves of `Concord' grapevines (Vitis labruscana Bailey) respond to a range of iron (Fe) supply. Own-rooted, 1-year-old container-grown vines were fertigated twice weekly for 11 weeks with a complete nutrient solution containing 1, 10, 20, 50, or 100 μm Fe from ferric ethylenediamine di (o-hydroxyphenylacetic) acid (Fe-EDDHA). Leaf total Fe content did not increase in response to Fe supply; however, “active” Fe (extracted with 2,2′-dipyridyl) and chlorophyll (Chl) increased on a leaf area basis as applied Fe incr

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43

Zhu, Wenming, Angela Wilks, and Igor Stojiljkovic. "Degradation of Heme in Gram-Negative Bacteria: the Product of the hemO Gene of Neisseriae Is a Heme Oxygenase." Journal of Bacteriology 182, no. 23 (2000): 6783–90. http://dx.doi.org/10.1128/jb.182.23.6783-6790.2000.

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ABSTRACT A full-length heme oxygenase gene from the gram-negative pathogenNeisseria meningitidis was cloned and expressed inEscherichia coli. Expression of the enzyme yielded soluble catalytically active protein and caused accumulation of biliverdin within the E. coli cells. The purified HemO forms a 1:1 complex with heme and has a heme protein spectrum similar to that previously reported for the purified heme oxygenase (HmuO) from the gram-positive pathogen Corynebacterium diphtheriae and for eukaryotic heme oxygenases. The overall sequence identity between HemO and these heme oxygenases is,

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44

Durham, Paul L., and Jonathan E. Poulton. "Enzymic Properties of Purified Myrosinase from Lepidium sativum Seedlings." Zeitschrift für Naturforschung C 45, no. 3-4 (1990): 173–78. http://dx.doi.org/10.1515/znc-1990-3-406.

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Abstract To establish the substrate specificity of the thioglucoside glucohydrolase myrosinase (EC 3.2.3.1), this enzyme was purified to homogeneity from light-grown cress (Lepidium sativum L.) seedlings by Sephadex gel filtration. Red Dye and anion exchange (FPLC Mono Q) chromatography, and preparative isoelectric focusing. Hydrolytic activity was shown toward only 4 of the 29 synthetic and natural O-and S-glycosides tested. Highest activity was displayed with the endogenous glucosinolates benzylglucosinolate (Km, 295 μM) and sinigrin (Km, 300 μM) at an optimum pH of 5.5 in sodium citrate bu

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45

Kim, Jin-Sol, Chulyung Choi, and Hyun-Hwa Lee. "Changes in the Biological Activities of Gracilaria verrucosa Extracted Using Different Extraction Solvents." Applied Sciences 13, no. 22 (2023): 12314. http://dx.doi.org/10.3390/app132212314.

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This study investigated the antioxidant, antiaging, and antibacterial properties of Gracilaria verrucosa (GV) based on 95% methanol (GVM), ethanol (GVE), and hot water (GVW) extractions. Antioxidant activity assays revealed the total polyphenol and flavonoid contents were highest in GVM and GVE. The 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2′-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) activities were highest in GVE and GVM. Furthermore, GVE exhibited the highest ferric-reducing antioxidant power (FRAP) value. In comparison, superoxide dismutase (SOD), catalase (CAT), an

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46

Rekha Kumari, Hariprasad Rao L, Gopinath T T, and Pandiyan K R. "Investigation on Haematinic accessible Assortments and Measurable Structures available in Indian Markets." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 704–8. http://dx.doi.org/10.26452/ijrps.v11ispl4.4022.

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To investigate Haematinic definitions accessible in India arcade for their assortments of measurements structures, hard salts utilized, the substance of essential iron, recurrence of organization compulsory, the occurrence of extra supplements, levelheadedness and price. Haematinic details recorded in IDR 2018, were investigated for salts of Iron present. Arrangements of ferrous fumarate were additionally investigated for Iron substance, presence of folic corrosive and other included extra parts. A sum of 522 plans, 291 (55.74%) was oral strong measurement structure, 206 (39.46%) were oral flu

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47

McAnulty, S. R., P. A. Hosick, L. S. McAnulty, et al. "Effect of pharmacological lowering of plasma urate on exercise-induced oxidative stress." Applied Physiology, Nutrition, and Metabolism 32, no. 6 (2007): 1148–55. http://dx.doi.org/10.1139/h07-131.

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Urate is a metabolic end product of purine metabolism that contributes about 66% of the antioxidant capacity of plasma. The objective of this study was to evaluate the importance of plasma urate as an antioxidant using pharmacological lowering and examining the impact on plasma antioxidant capacity and oxidative stress after intense exercise. Fifteen subjects ran for 45 min at ~80% VO2 max under the influence of probenecid (1 g/d) (PRO) or placebo (PLA) in a double-blind, crossover design. Blood samples obtained at baseline, pre-exercise, and immediately post-exercise were analyzed for F2-isop

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48

Santos, Carla S., Rengin Ozgur, Baris Uzilday, et al. "Understanding the Role of the Antioxidant System and the Tetrapyrrole Cycle in Iron Deficiency Chlorosis." Plants 8, no. 9 (2019): 348. http://dx.doi.org/10.3390/plants8090348.

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Iron deficiency chlorosis (IDC) is an abiotic stress often experienced by soybean, owing to the low solubility of iron in alkaline soils. Here, soybean lines with contrasting Fe efficiencies were analyzed to test the hypothesis that the Fe efficiency trait is linked to antioxidative stress signaling via proper management of tissue Fe accumulation and transport, which in turn influences the regulation of heme and non heme containing enzymes involved in Fe uptake and ROS scavenging. Inefficient plants displayed higher oxidative stress and lower ferric reductase activity, whereas root and leaf ca

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49

Singh, Soares, Goufo, et al. "Chitosan Upregulates the Genes of the ROS Pathway and Enhances the Antioxidant Potential of Grape (Vitis vinifera L. ‘Touriga Franca’ and ’Tinto Cão’) Tissues." Antioxidants 8, no. 11 (2019): 525. http://dx.doi.org/10.3390/antiox8110525.

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Chitosan is an environmentally-friendly active molecule that has been explored for numerous agricultural uses. Its use in crop protection is well-known, however, other properties, such as bioactivity, deserve attention. Moreover, the modes of actions of chitosan remain to be elucidated. The present study assessed the levels of total phenolic compounds, the antioxidant potential, and the expression of reactive oxygen species (ROS) scavenging genes in the berries (skins and seeds), leaves, cluster stems, and shoots upon chitosan application on two red grapevine varieties (Touriga Franca and Tint

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50

Saber, Mohamed, Mohamed Khalaf, Ahmed M. Abbas, and Sayed A. Abdullah. "Management of postpartum iron deficiency anemia: review of literature." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 1 (2018): 338. http://dx.doi.org/10.18203/2320-1770.ijrcog20185450.

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Anemia is a condition in which either the number of circulating red blood cells or their hemoglobin concentration is decreased. As a result, there is decreased transport of oxygen from the lungs to peripheral tissues. The standard approach to treatment of postpartum iron deficiency anemia is oral iron supplementation, with blood transfusion reserved for more server or symptomatic cases. There are a number of hazards of allogenic blood transfusion including transfusion of the wrong blood, infection, anaphylaxis and lung injury, any of which will be devastating for a young mother. These hazards,

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