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Готові списки джерел за темами / Fibroblasts reprogramming

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Добірка наукової літератури з теми "Fibroblasts reprogramming"

Автор: Grafiati

Опубліковано: 14 березня 2023

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Дисертації з теми "Fibroblasts reprogramming"

1

Elyaderani, Parisa Javadian. "Reprogramming of fibroblasts by the Piwil2 gene." Thesis, University of Newcastle Upon Tyne, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613436.

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The Piwil2 gene belongs to the Piwi family of genes conserved during evolution from Arabidopsis to human. The Piwi family genes are considered as stem cell modulators functioning in meristem cell division in Arabidopsis and germ stem cell propagation in C.elegans and in mammals. Although some essential functions such as germ cell development, transposition repression, epigenetic modification and translational regulation, as well as stem cell and cancer stem cell maintenance, are attributed to this family of genes, the detailed mechanism of the function of these genes still remains elusive. In

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2

Rohanisarvestani, Leili. "Integration-free mRNA reprogramming of human fibroblasts: The study of aging upon reprogramming." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-159985.

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The ability to reprogram adult somatic cells into induced pluripotent stem (iPS) cells could provide a valuable implement for in vitro disease modeling and drug discovery. More importantly, they may potentially serve as an unlimited source of cells for regenerative medicine. However, most of the iPS cells have been generated by retroviral vectors, and therefore they carry the risk of viral integration into the host genome. This problem prevents their use for clinical applications and regenerative medicine. mRNA-mediated delivery of reprogramming factors is an alternative approach for cellular

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3

Karamariti, Eirini. "Direct reprogramming of fibroblasts into smooth muscle cells." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/direct-reprogramming-of-fibroblasts-into-smooth-muscle-cells(d0feb08f-4d4a-4ded-a2b3-00e41c575cec).html.

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The generation of induced pluripotent stem (iPS) cells is a useful tool for regenerative medicine. However, the risk of tumor development of the aforementioned cells should be addressed before they can be used for clinical applications. During the reprogramming process a number of signal pathways are activated, which may lead to direct differentiation of specific cell lineages prior to the cells reaching the pluripotent state. In order to test this hypothesis we designed a combined protocol of reprogramming and differentiation in an attempt to achieve direct differentiation of fibroblasts to s

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4

Rohanisarvestani, Leili [Verfasser], Friedemann [Gutachter] Horn, and Torsten [Gutachter] Remmerbach. "Integration-free mRNA reprogramming of human fibroblasts: The study of aging upon reprogramming / Leili Rohanisarvestani ; Gutachter: Friedemann Horn, Torsten Remmerbach." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1238525598/34.

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5

Hao, Ru. "Reprogramming of mesenchymal stem cells and adult fibroblasts following nuclear transfer in rabbits." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-96652.

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6

MAZZARA, PIETRO GIUSEPPE. "TWO FACTOR BASED REPROGRAMMING OF FIBROBLASTS AND INDUCED PLURIPOTENT STEM CELLS INTO MYELINOGENIC SCHWANN CELLS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199039.

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Le cellule di Schwann (SC) sono cellule derivate dalla cresta neurale (NC) in grado di produrre la guaina mielinica avvolgendo gli assoni neuronali nel sistema nervoso periferico (PNS). I trapianti di SC potrebbero diventare un'opportunità terapeutica interessante per il trattamento delle lesioni del midollo spinale, dei nervi periferici e delle malattie demielinizzanti del PNS. Tuttavia, questi approcci terapeutici sono fortemente limitati dall'attuale mancanza di una fonte rinnovabile di SC. Le strategie di riprogrammazione cellulare si sono rivelate efficaci nel fornire una varietà di cellu

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7

Tanabe, Koji. "Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts." Kyoto University, 2013. http://hdl.handle.net/2433/180465.

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8

Bachamanda, Somesh Dipthi [Verfasser]. "Induced cardiomyocyte precursor cells obtained by direct reprogramming of cardiac fibroblasts / Dipthi Bachamanda Somesh." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223925676/34.

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9

Raciti, Marilena. "Reprogramming fibroblasts to neural-stem-like cells by structured overexpression of pallial patterning genes." Doctoral thesis, SISSA, 2012. http://hdl.handle.net/20.500.11767/3924.

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In this study, we assayed the capability of four genes implicated in embryonic specification of the cortico-cerebral field, Foxg1, Pax6, Emx2 and Lhx2, to reprogramm mouse embryonic fibroblasts toward neural identities. Lentivirus-mediated, TetON-dependent overexpression of Pax6 and Foxg1 transgenes specifically activated the neural stem cell (NSC) reporter Sox1-EGFP in a substantial fraction of engineered cells. The efficiency of this process was enhanced up to ten times by simultaneous inactivation of Trp53 and co-administration of a specific drug mix inhibiting HDACs, H3K27-HMTase and H3K4

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10

Kole, Denis. "Role of Fibroblast Growth Factor 2 in Maintenance of Multipotency in Human Dermal Fibroblasts Treated with Xenopus Laevis Egg Extract Fractions." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-dissertations/207.

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Анотація:

Current usage of human embryonic stem cells (hES) and induced pluripotent stem cells (iPS) in clinical therapies and personalized medicine are limited as a result of ethical, technical and medical problems that arise from isolation and generation of these cells. Isolation of hES cells faces ethical problems associated with their derivation from human pre-implantation embryos. The most controversial aspect of hES cell isolation targets the generation of autologous hES cell lines which requires the transfer of a somatic-cell nucleus from the patient to an enucleated oocyte. While already establi

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