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1

Belgioioso, Giulia. "Les racines suaréziennes de la métaphysique cartésienne : La lecture des Principia de Francesco Maria Spinelli (1733)/ Suarezian roots of Cartesian metaphysics: Francesco Maria Spinelli's reading of the Principia philosophiae." Revue d'histoire des sciences 58, no. 1 (2005): 123–44. http://dx.doi.org/10.3406/rhs.2005.2239.

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2

Ceccarelli, F., F. Natalucci, C. Perricone, et al. "FRI0159 EROSIVE ARTHRITIS IN SYSTEMIC LUPUS ERYTHEMATOSUS: APPLICATION OF CLUSTER ANALYSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 663–64. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4245.

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Background:Systemic Lupus Erythematosus (SLE) related arthritis has been traditionally defined non-erosive and then considered a minor manifestation. Thanks to the application of more sensitive imaging techniques, such as ultrasonography (US), erosive damage has been identified in up to 40% of SLE patients with joint involvement, suggesting the need for more appropriate treatment (1). Antibodies directed against citrullinated and carbamilated proteins (ACPA and anti-CarP, respectively) have been associated with erosive damage and then proposed as biomarkers for this more aggressive phenotype (
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3

Ceccarelli, F., G. Olivieri, L. Dominici, et al. "OP0204 LUPUS COMPREHENSIVE DISEASE CONTROL IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS: APPLICATION OF A NEW INDEX." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 127.1–127. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4560.

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Background:The main outcomes in SLE patients management are represented by the remission achievement and chronic damage prevention. Even though activity and damage are intimately connected, to date indices including both these outcomes are not available.Objectives:In the present study, we aimed at assessing the application of a new index, the Lupus comprehensive disease control (LupusCDC), including disease activity and chronic damage progression.Methods:We performed a longitudinal analysis, including SLE patients according to ACR 1997 criteria, followed-up in the period between January 2014 a
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4

Orefice, V., F. Ceccarelli, C. Barbati, et al. "THU0227 CAFFEINE INTAKE MODULATES DISEASE ACTIVITY AND CYTOKINES LEVELS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 340.2–341. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2100.

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Background:Systemic lupus erythematosus (SLE) is an autoimmune disease mainly affecting women of childbearing age. The interplay between genetic and environmental factors may contribute to disease pathogenesis1. At today, no robust data are available about the possible contribute of diet in SLE. Caffeine, one of the most widely consumed products in the world, seems to interact with multiple components of the immune system by acting as a non-specific phosphodiesterase inhibitor2.In vitrodose-dependent treatment with caffeine seems to down-regulate mRNA levels of key inflammation-related genes a
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5

Cazden, Courtney B., and Charles Haynes. "School discourse problems. Danielle N. Ripich & Francesca M. Spinelli (Eds.). San Diego: College-Hill, 1985. Pp. xiii + 279." Applied Psycholinguistics 7, no. 4 (1986): 394–96. http://dx.doi.org/10.1017/s0142716400007761.

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6

Ariani, A., E. Bravi, M. De Santis, et al. "OP0063 QUANTITATIVE COMPUTED TOMOGRAPHY PREDICTS 10-YEAR MORTALITY IN INTERSTITIAL LUNG DISEASE RELATED TO SYSTEMIC SCLEROSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 42.1–42. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2239.

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Background:Interstitial lung disease (ILD) is the main cause of death in Systemic Sclerosis (SSc). Chest CT is the gold standard in detecting ILD although it is not easy to understand its prognostic value. ILD qualitative assessment is almost worthless. Goh et al. semi quantitative score of ILD extent is related to mortality risk but it is burdened by relevant inter/intra-readers variability. An operator independent algorithm based on voxel-wise analysis proved to identify SSc patients with an increased risk of mortality according to prediction models.Objectives:To verify if quantitative analy
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7

Alexandre, Gabriel Guimarães. "O papel da memória discursiva em manchetes que desmentem notícias sobre Covid-19." Scripta 25, no. 54 (2021): 68–95. http://dx.doi.org/10.5752/p.2358-3428.2021v25n54p68-95.

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A pandemia de Covid-19 trouxe-nos um contexto de exceção. Restrições impostas à sociedade foram aplicadas por governos de diferentes partes do mundo, gerando dificuldades, por exemplo, de escolha entre ter privacidade de dados ou saúde prometida por vigilância biométrica (HARARI, 2020). Como “resposta” à disseminação de fake news – não só sobre a doença, mas também sobre outros temas – as agências de fact-checking (PANGRAZIO, 2018; SPINELLI, SANTOS, 2018) surgem com o objetivo de verificá-las, classificando-as em “verdadeiras” ou “falsas”, segundo gradação. Quando publicam a checagem realizada
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8

Olivieri, G., F. Ceccarelli, A. Lo Presti, et al. "THU0281 EXPLORING THE GENETIC DIVERSITY OF STAPHYLOCOCCUS AUREUS IN PATIENTS AFFECTED BY SYSTEMIC LUPUS ERYTHEMATOSUS: ASSOCIATION WITH DISEASE-RELATED FEATURES AND ACTIVITY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 367.1–368. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3592.

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Background:Infective factors play a central role in autoimmune diseases pathogenesis. It is possible to speculate that the host genotype could interact with genetic background of infective agents. We previously evaluated a large SLE cohort, observing the association between theS. Aureus(SA) carriage status and presence of a more active disease in terms of autoantibodies positivity.Objectives:We evaluated epidemiological, molecular characterization, genetic diversity and evolution of SA isolated from SLE patients by means of phylogenetic analysis.Methods:Consecutive SLE patients (ACR 1997 crite
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9

Natalucci, F., F. Ceccarelli, E. Cipriano, et al. "THU0627-HPR JOINT INVOLVEMENT SIGNIFICANTLY INFLUENCES QUALITY OF LIFE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 557–58. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3791.

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Background:Joint involvement is one of the most common features observed in Systemic Lupus Erythematosus (SLE), potentially involving up to 90% of patients [1]. Several patients’ reported outcomes (PROs) have been employed to measure Quality of life (QoL) in SLE patients, but frequently not specifically developed for SLE patients. More recently, the LupusQoL has been validated, a disease specific questionnaire[2,3].Objectives:We focused at assessing the relationship between musculoskeletal manifestations and QoL in a large SLE cohort, by using the LupusQoL.Methods:SLE patients with a clinical
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10

Barbati, C., F. R. Spinelli, C. Garufi, et al. "AB0085 MODULATION OF CIRCULATING SKELETAL STAMINAL CELLS IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH TOFACITINIB." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1342–43. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4314.

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Background:Rheumatoid arthritis (AR) is an autoimmune systemic inflammatory disease characterized by chronic synovial inflammation resulting in bone damage and erosions, with consequently functional disability. Currently, attempts for regenerative therapies for osteo-cartilage pathologies have proved unsuccessful. Recently, a “pool” of skeletal stem cells (hSSCs: human skeletal stem cells) able to generating bone cells, has been identified in human bone (1).Objectives:In light of these observations, we aim at characterizing skeletal stem cells in peripheral blood from RA patients candidate to
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11

Pacucci, V. A., C. Barbati, F. R. Spinelli, et al. "AB0355 EFFECT OF TOFACITINIB IN TREG /TH17 BALANCE IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1477.2–1478. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4403.

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Background:Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease that can cause progressive articular destruction (1). The imbalance between Tregs and Th17-cells - an effector T-cell subset acting as Treg antagonists – is closely linked to autoimmunity (2). A shift in the Th17/Treg balance towards the pro-inflammatory Th17 side has been reported in many autoimmune disorders including RA (4-5). Tofacitinib is the first janus kinases (JAK) inhibitor (JAKi) approved for the treatment of RA and it binds to and competitively inhibits the kinase domain of JAK3, JAK1 and, to a lesser deg
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12

Garufi, C., F. Ceccarelli, F. R. Spinelli, S. Mancuso, C. Pirone, and F. Conti. "POS0677 THE ROLE OF MUSCULOSKELETAL ULTRASOUND IN PREDICTING THE RESPONSE TO JAK INHIBITORS: RESULTS FROM A LARGE MONOCENTRIC COHORT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 583. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3850.

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Background:In the management of chronic arthritis, such as Rheumatoid Arthritis (RA), Ultrasound (US) assessment can provide relevant information about the joint inflammatory status in the diagnostic phase and even more in the monitoring of disease activity and structural damage1,2.Objectives:In this longitudinal study, we aimed to assesse the role of US in predicting the efficacy of JAK-inhibitors (JAKi) in RA patients.Methods:We enrolled RA patients starting baricitinib or tofacitinib. All patients were evaluated at baseline and after 4, 12, 24, 48 weeks. Disease activity was calculated by D
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13

Lucchino, B., M. Leopizzi, T. Colasanti, et al. "FRI0376 EFFECT OF CARBAMYLATED LOW-DENSITY LIPOPROTEINS ON BONE CELLS HOMEOSTASIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 784.2–785. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2741.

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Background:Carbamylation is a post-translational modification occurring under several conditions such as uremia, smoking and chronic inflammation as in rheumatoid arthritis (RA). Low-density lipoproteins (LDL) represent a target of carbamylation. Carbamylated-LDL (cLDL) have an increased inflammatory and atherogenic potential. Growing evidence supports an influence of modified lipids on bone cells homeostasis. However, the role of cLDL on bone cells physiology is still unknown.Objectives:Considering the rate of carbamylation and the role of anti-carbamylated proteins antibodies as markers of e
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14

Pacucci, V. A., F. R. Spinelli, K. Giannakakis, et al. "SAT0223 TUBULO-INTERSTITIAL INFILTRATES IN LUPUS NEPHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1054.1–1055. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1296.

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Background:Lupus nephritis (LN) occurs in up to 60% of patients affected by Systemic Lupus Erythematosus (SLE). The presence of inflammatory infiltrates in glomeruli and/or in tubulo-interstitium (TI) plays an important role in terms of prognosis (1). Ectopic lymphoid structures (ELSs) are clusters of organized lymphoid infiltrates forming at sites of chronic inflammation in non-lymphoid organs (2). Data on ELSs in kidneys of SLE patients are scant (3-5).Objectives:The aim of the study was to evaluate the tubule-interstitial infiltrates (TI-I) organization and to investigate the presence of EL
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15

Cipriano, E., F. Ceccarelli, F. R. Spinelli, et al. "SAT0555 MUSCULOSKELETAL ULTRASOUND IN MONITORING RESPONSE TO JAKi IN RHEUMATOID ARTHRITIS PATIENTS: RESULTS FROM A LONGITUDINAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1235–36. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5987.

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Background:Therapeutic approach of rheumatoid arthritis (RA) patients has been enriched by the introduction of small molecules. In particular Jak inhibitors (JAKi), baricitinib and tofacitinib, demonstrated their efficacy in patients naïve or resistant to biological treatments in randomized controlled trials. Moreover, these drugs seem to be able to prevent radiographic progression. To date few data are available from the real life context. Ultrasonographic (US) assessment has became a valid imaging tool in the management of RA patients in clinical practice, allowing the evaluation of joint in
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16

Pirone, C., F. Ceccarelli, A. Selntigia, et al. "SAT0228 PREGNANCY OUTCOME IN SYSTEMIC LUPUS ERYTHEMATOSUS: A MONOCENTRIC COHORT ANALYSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1056.1–1057. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3106.

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Background:Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease, affecting prevalently women in childbearing age. Thanks to pre-gestational counseling and multi-disciplinary approach, adopted in daily clinical practice, SLE patients are experiencing even more uncomplicated pregnancies.Objectives:Here, we evaluated pregnancy outcome in a large SLE cohort, compared to a control group including pregnant women without autoimmune diseases.Methods:Pregnant SLE patients (diagnosis made according to ACR 1997 criteria) were included in the present study, conducted in the context of a join
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17

Cacciapaglia, F., A. Manfredi, G. Erre, et al. "THU0257 ESTIMATED 10-YEARS CARDIOVASCULAR RISK IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS: PRELIMINARY RESULTS FROM THE “CARDIOVASCULAR OBESITY AND RHEUMATIC DISEASE (CORDIS)” STUDY GROUP OF THE ITALIAN SOCIETY OF RHEUMATOLOGY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 355.2–356. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6187.

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Background:Systemic lupus erythematosus (SLE) patients are at high risk for CV events, and EULAR recommends assessing the 10-year CV-risk using the Systematic Coronary Risk Evaluation (SCORE) [1]. The QRISK3, another score to assess CV-risk in UK population, considers different factors among which also SLE. The Progetto Cuore score (PCS) is validated to estimate CV risk in Italian people and largely replicates the SCORE project [2].Objectives:This cross-sectional study aimed to estimate CV-risk using SCORE, QRISK3 and, for the first time, PCS in a multicentric cohort of Italian SLE patients.Me
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18

Mancuso, S., S. Truglia, S. Recalchi, et al. "FRI0145 FOLLOW-UP OF A MONOCENTRIC COHORT OF SERONEGATIVE ANTIPHOSPHOLIPID SYNDROME." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 656.1–657. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2928.

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Background:Seronegative antiphospholipid syndrome (SN-APS) is the term proposed to describe patients with clinical signs highly suggestive of APS but persistently negative for conventional antiphospholipid antibodies (aPL) assays. Therefore, new antigenic targets or different methodological approaches have been investigated to detect aPL in SN-APS [1].Objectives:The aim of this study was to describe the clinical follow-up of a monocentric cohort of SN-APS patients.Methods:The study included all consecutive SN-APS patients examined from 2014 to 2018. In all patients other possible causes of thr
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19

Garufi, C., F. R. Spinelli, S. Mancuso, F. Ceccarelli, and F. Conti. "AB0704 TELEMEDICINE AT THE TIME OF COVID-19: THE EXPERIENCE WITH RA PATIENTS TREATED WITH JAK-INHIBITORS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1384.1–1384. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3892.

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Background:The spread of COVID-19, the lockdown, the limited access to care reevaluated the role of tele-consultation and self-assessment.Objectives:Our aim was to evaluate in a cohort of Rheumatoid Arthritis (RA) patients treated with JAK-inhibitors (JAKi): the self-assessed disease activity during lockdown, the lockdown impact on fatigue, anxiety, depression and the prevalence of Covid-19.Methods:We enrolled RA patients treated with baricitinib or tofacitinib. At baseline (BL) and follow-up we collected: patients’ demographic data, composite disease activity indices (CDAI, DAS28CRP), global
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20

Campochiaro, C., G. De Luca, M. G. Lazzaroni, et al. "POS0890 NINTEDANIB REAL-LIFE EFFICACY AND SAFETY IN SYSTEMIC SCLEROSIS (SSc)-INTERTISTIAL LUNG DISEASE (ILD): AN ITALIAN MULTICENTRE PRELIMINARY STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 741.2–742. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3183.

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BackgroundNintedanib (NTD) has been approved for Systemic Sclerosis (SSc)-Interstitial Lung Disease (ILD) following the positive results of the SENSCIS trial.Objectivesto describe the efficacy and safety of NTD in SSc-ILD in a real-life setting.MethodsThe clinical data of SSc-ILD patients treated with NTD from 10 Italian SSc centres were retrospectively evaluated at baseline, 6 and 12 months: SSc clinical features, NTD tolerability, pulmonary function tests (PFTs) and modified Rodnan skin score (mRSS) were recorded.Results69 SSc-ILD patients (22 males [32%], mean age 60±12 years, disease onset
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21

Oliviero, F., F. Galuppini, A. Scanu, et al. "OP0174 POLYDATIN PREVENTS CALCIUM PYROPHOSPHATE CRYSTAL-INDUCED ARTHRITIS IN MICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 108.1–109. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2124.

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Background:Acute calcium pyrophosphate (CPP) crystal-induced inflammation is characterized by the massive release of cytokines and pro-inflammatory mediators and, from a clinical point of view, pain and limited joint function. Contrary to the precipitation of urate crystals that can be prevented through the use of hypouricemic drugs, there is no pharmacological therapy that can prevent the formation of pyrophosphate crystals.Polydatin (PD),a natural precursor of resveratrol, is a stilbenoid mainly contained in grape juice and bark of Polygonum Cuspidate. Its antioxidant, anti-inflammatory and
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22

Andreoli, L., S. Alivernini, A. Alunno, et al. "AB1265 GENDER DISTRIBUTION AND GENDER-RELATED ISSUES AMONG YOUNG RHEUMATOLOGISTS AND ACADEMIC POSITIONS IN RHEUMATOLOGY: A SNAPSHOT OF THE CURRENT SITUATION IN ITALY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1924.1–1924. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3123.

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Background:The Italian Society for Rheumatology (SIR) comprises committees for Rheumatologists under the age of 40 (SIRyoung) and for Women in Rheumatology (Reumatologhe Donne – ReDO). As female representation is increasing in rheumatology worldwide [1], there has been interest in assessing gender-related issues.Objectives:To describe the gender distribution among young members of SIR and academic positions in Rheumatology in Italy. To assess the expectations and needs of young rheumatologists with regard to their career.Methods:SIRyoung members developed a web-based survey which was distribut
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23

Garufi, C., F. R. Spinelli, F. Ceccarelli, et al. "AB0340 EFFECT OF BARICITINIB ON RANKL SERUM CONCENTRATION IN RHEUMATOID ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1468.1–1469. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4399.

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Background:RANKL (receptor activator of nuclear factor κB ligand) and osteoprotegerin, the main regulators of bone metabolism, are involved in osteoblasts/osteoclasts balance in inflammatory disease, such as Rheumatoid Arthritis (RA). Janus kinase (JAK) inhibitors (baricitinib and tofacitinib) can reduce the progression of structural damage in patients with moderate to severe RA. Previous studies suggest a link between JAK inhibition, production of RANKL and osteoclastogenesis1,2.Objectives:to investigate the effect of baricitinib on RANKL serum concentration in unselected RA patients.Methods:
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24

Duca, I., F. R. Spinelli, F. Ceccarelli, et al. "FRI0121 STEROID-SPARING EFFECT OF JAK INHIBITORS IN RHEUMATOID ARTHRITIS PATIENTS FOLLOWED UP IN A REAL LIFE SETTING." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 641.2–642. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5998.

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Background:Glucocorticoids (GCs) are a milestone of Rheumatoid Arthritis (RA) treatment; EULAR recommendations on the management of medium to high dose glucocorticoids remind to evaluate comorbidities and risk factors for adverse events when planning GCs treatment. Tofacitinib and Baricitinib are Janus kinases inhibitors (JAKi) registered for RA treatment. About 60% of patients enrolled in randomized clinical trials with JAKi were co-treated with GCs; however, little is known about tapering and percentage of withdrawal both in clinical trials and real life.Objectives:To evaluate the steroid-sp
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25

Garufi, C., G. Tucci, I. Pacella, et al. "AB0087 THE EFFECT OF BARICITINIB ON STAT1 PHOSPHORYLATION IN MONOCYTES FROM RHEUMATOID ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1175.1–1175. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4332.

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Анотація:
BackgroundBaricitinib is a Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA)1-2. STAT proteins bind JAK kinase dimers coupled with cytokine receptors and regulate gene transcription. The JAK/STAT system is responsible for the intracellular signaling of different cytokines contributing to the activation process of the monocyte lineage, therefore the use of JAK inhibitors can affect cell functionality3-6.ObjectivesThe aim of the present study was to verify the effects of baricitinib on STAT phosphorylation in peripheral mononuclear cells (PBMCs) of RA pat
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26

De Martino, E., P. Conigliaro, M. S. Chimenti, et al. "AB0679 HEALTH ASSESSMENT IN FEMALE PATIENTS WITH SPONDYLOARTHRITIS: FOCUS ON REPRODUCTIVE SPHERE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1634.2–1635. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4719.

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Background:SpA patients experience a decreased quality of life due to social, emotional and relational life impairment in addition to pain, fatigue and joint damage. Sexual dysfunction (SD) is often neglected by both patients and clinicians, although articular and extra-articular manifestations of the disease can decrease the quality of sexual life. Previous findings showed that SD can affect from 27% to 67% of patients with rheumatic diseases. Data available on SD in rheumatic patients are poor and primarily focus on male ankylosing spondylitis patientsObjectives:The aim of this study is to e
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27

De Brito, Rodrigo Pinto, and Rafael Huguenin. "Tradução de sexto empírico, ‘Contra os astrólogos’, 1-22." Prometheus - Journal of Philosophy, August 14, 2015. http://dx.doi.org/10.52052/issn.2176-5960.pro.v8i18.3945.

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Анотація:
Tradução grego-português de Sexto Empírico, Contra os astrólogos, 1-22 (= M V 1-22), a partir da fixação de Bekker (BEKKER, I. Sextus Empiricus [opera omnia]. Berlim: Typis et Imprensis Ge. Reimeri, 1842), adotando as emendas de H. Mutschmann (MUTSCHMANN, H. Sexti Empirici Opera. v. III. Leipzig: Bibliotheca Scriptorum Graecorum et Romanorum Teubneriana, 1912). Para cotejo, usamos a mui influente versão latina de Henri Estienne e Gentian Hervet (STEPHANI, H.; HERVET, G. Sexti Empirici Opera Graeca et Latini. Leipzig: Sumptu Librariae Kuehnianae, 1841), além da versão inglesa de R. G. Bury, a r
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