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Статті в журналах з теми "FTO gene"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Doaei, Saeid, Naser Kalantari, Nastaran Keshavarz Mohammadi, et al. "The Role of FTO Genotype in the Association Between FTO Gene Expression and Anthropometric Measures in Obese and Overweight Adolescent Boys." American Journal of Men's Health 13, no. 1 (2018): 155798831880811. http://dx.doi.org/10.1177/1557988318808119.

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Анотація:

The role of FTO genotype in the effect of FTO gene expression level on change in body mass index and body composition has not been studied. This study aimed to investigate the role of FTO genotype in the association between change in the expression level of the FTO gene with changes in anthropometric measurements in obese and overweight adolescent boys. Eighty-four boys aged 12 to 16 years participated in this longitudinal study. A bioimpedance analyzer (BIA) was used to estimate percentage of body fat (%body fat) and percentage of skeletal muscle (%skeletal muscle). The FTO gene expression le

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2

Clemente, Gabriel David da Silva, Rian Barreto Arrais Rodrigues de Morais, Leonardo Torres Camurça, et al. "Investigação da conexão entre o gene associado a massa gorda e obesidade (FTO) com a predisposição ao Diabetes: revisão sistemática." Caderno Pedagógico 21, no. 8 (2024): e7261. http://dx.doi.org/10.54033/cadpedv21n8-276.

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Com o aumento do diabetes, a influência genética, especialmente o polimorfismo do gene FTO, é extensivamente estudada em relação a essa condição, considerando também fatores ambientais e comportamentais. Dessa maneira, objetivou-se avaliar a relação entre o gene FTO e a predisposição ao diabetes. O presente estudo compreende uma revisão sistemática da literatura científica abrangendo as seguintes fases: (1) formulação da pergunta de pesquisa; (2) estipulação de objetivos; (3) delineamento dos critérios de inclusão e exclusão; (4) especificação das informações a serem obtidas dos artigos seleci

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3

Doaei, Saeid, Maryam Gholamalizadeh, Alireza Mousavi Jarrahi, Marjan Badakhanian, and Rahim Najafi. "The IRX3 Gene; the Missing Link between the FTO Gene and Obesity." Asian Pacific Journal of Cancer Biology 1, no. 2 (2016): 33–35. http://dx.doi.org/10.31557/apjcb.2016.1.2.33-35.

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Aims: The aim of this study was the investigation of the mediator role of the IRX3 gene in the relationship between the FTO gene and obesity.Materials and Methods: All related articles published in English from June 1990 to February 2017 were studied.Results: Only a Few studies have examined the association between the IRX3 gene with the FTO gene and obesity. However, all of them reported that the FTO gene can influence the IRX3 gene expression. Also, it’s reported that the IRX3 gene expression level has a significant association with body weight and body composition. Conclusions: The FTO gene

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4

Ren, Wei, Jianjin Guo, Feng Jiang та ін. "CCAAT/Enhancer-Binding ProteinαIs a Crucial Regulator of Human Fat Mass and Obesity Associated Gene Transcription and Expression". BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/406909.

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Анотація:

Several susceptibility loci have been reported associated with obesity and T2DM in GWAS. Fat mass and obesity associated gene (FTO) is the first gene associated with body mass index (BMI) and risk for diabetes in diverse patient populations. FTO is highly expressed in the brain and pancreas, and is involved in regulating dietary intake and energy expenditure. While much is known about the epigenetic mutations contributing to obesity and T2DM, less is certain with the expression regulation of FTO gene. In this study, a highly conserved canonical C/EBPαbinding site was located around position −4

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5

BEDİK, Dina, Gizem KIRMIZIOĞLU, and Iraz AKIŞ. "Association of the FTO gene with obesity and cancer in dogs." Journal of Istanbul Veterinary Sciences 7, no. 3 (2023): 118–31. http://dx.doi.org/10.30704/http-www-jivs-net.1349652.

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Nowadays, obesity is one of the most serious problems that significantly affect health in both human and animal populations. Fat mass and obesity-associated gene (FTO), increases the risk of obesity and other metabolic diseases such as cancer, with taking part in many complex molecular pathways. On the other hand, environmental and genetic factors cause changes in FTO gene variants and expression levels, which result in phenotypic differences. Advanced knowledge on the genetic basis of human FTO gene and its association with cancer and obesity, has paved the way for the investigation of FTO ge

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6

Jawiarczyk-Przybyłowska, Aleksandra, Justyna Kuliczkowska-Płaksej, Katarzyna Kolačkov, et al. "FTO Gene Polymorphisms and Their Roles in Acromegaly." International Journal of Molecular Sciences 24, no. 13 (2023): 10974. http://dx.doi.org/10.3390/ijms241310974.

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The major causes of both morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVDs). The polymorphisms of the fat mass and obesity-associated gene (FTO) are associated with obesity, as well as with an increased risk of CVDs. The aim of the study was to determine the relationship of risk alleles of four FTO gene polymorphisms with selected parameters of lipid and glucose metabolism as well as with IGF-1 and GH levels in the group of patients with acromegaly compared to the control group. The study group consisted of 104 patients with acromegaly and 64 healthy subject

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7

Karolina Flaga, Anna, Anna Mach, and Grażyna Gromadzka. "FTO gene variants and consumption of alcoholic beverages." Alcoholism and Drug Addiction 33, no. 4 (2020): 341–62. http://dx.doi.org/10.5114/ain.2020.104816.

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8

Liu, Shu-Jing, Hui-Ling Tang, Qian He, et al. "FTO is a transcriptional repressor to auto-regulate its own gene and potentially associated with homeostasis of body weight." Journal of Molecular Cell Biology 11, no. 2 (2018): 118–32. http://dx.doi.org/10.1093/jmcb/mjy028.

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Abstract Fat mass and obesity-associated (FTO) protein is a ferrous ion (Fe2+)/2-oxoglutarate (2-OG)-dependent demethylase preferentially catalyzing m6A sites in RNA. The FTO gene is highly expressed in the hypothalamus with fluctuation in response to various nutritional conditions, which is believed to be involved in the control of whole body metabolism. However, the underlying mechanism in response to different nutritional cues remains poorly understood. Here we show that ketogenic diet-derived ketone body β-hydroxybutyrate (BHB) transiently increases FTO expression in both mouse hypothalamu

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9

Czogała, Wojciech, Wojciech Strojny, Magdalena Schab, et al. "FTO and PLAG1 Genes Expression and FTO Methylation Predict Changes in Circulating Levels of Adipokines and Gastrointestinal Peptides in Children." Nutrients 13, no. 10 (2021): 3585. http://dx.doi.org/10.3390/nu13103585.

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Adipokines and gastrointestinal tract hormones are important metabolic parameters, and both epigenetic factors and differential gene expression patterns may be associated with the alterations in their concentrations in children. The function of the FTO gene (FTO alpha-ketoglutarate dependent dioxygenase) in the regulation of the global metabolic rate is well described, whereas the influence of protooncogene PLAG1 (PLAG1 zinc finger) is still not fully understood. A cross-sectional study on a group of 26 children with various BMI values (15.3–41.7; median 28) was carried out. The aim was to eva

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10

Chang, Rui, Zeyi Huang, Size Zhao, Ju Zou, Yukun Li, and Sijie Tan. "Emerging Roles of FTO in Neuropsychiatric Disorders." BioMed Research International 2022 (April 26, 2022): 1–9. http://dx.doi.org/10.1155/2022/2677312.

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Анотація:

FTO (fat mass and obesity associated) is a recently discovered gene related to obesity and expressed in various tissues of the human body, especially with high expression in the brain. Earlier studies have found that FTO is involved in several biological processes, including brain development and function. In particular, recent studies have found that FTO is a demethylase of N6-methyladenosine (m6A) and it can affect neurological function through the m6A modification of mRNA. At present, a number of studies have shown that FTO is associated with many neuropsychiatric disorders. This paper revi

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11

Gao, Shuting, Xitong Li, Miao Zhang, Ning Zhang, Ruiyong Wang, and Junbiao Chang. "Structural characteristics of small-molecule inhibitors targeting FTO demethylase." Future Medicinal Chemistry 13, no. 17 (2021): 1475–89. http://dx.doi.org/10.4155/fmc-2021-0132.

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Анотація:

Studies have shown that the FTO gene is closely related to obesity and weight gain in humans. FTO is an N6-methyladenosine demethylase and is linked to an increased risk of obesity and a variety of diseases, such as acute myeloid leukemia, type 2 diabetes, breast cancer, glioblastoma and cervical squamous cell carcinoma. In light of the significant role of FTO, the development of small-molecule inhibitors targeting the FTO protein provides not only a powerful tool for grasping the active site of FTO but also a theoretical basis for the design and synthesis of drugs targeting the FTO protein. T

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12

Mizuno, Tooru. "Fat Mass and Obesity Associated (FTO) Gene and Hepatic Glucose and Lipid Metabolism." Nutrients 10, no. 11 (2018): 1600. http://dx.doi.org/10.3390/nu10111600.

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Common genetic variants of the fat mass and obesity associated (FTO) gene are strongly associated with obesity and type 2 diabetes. FTO is ubiquitously expressed. Earlier studies have focused on the role of hypothalamic FTO in the regulation of metabolism. However, recent studies suggest that expression of hepatic FTO is regulated by metabolic signals, such as nutrients and hormones, and altered FTO levels in the liver affect glucose and lipid metabolism. This review outlines recent findings on hepatic FTO in the regulation of metabolism, with particular focus on hepatic glucose and lipid meta

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13

Hunt, Steven C., Steven Stone, Yuanpei Xin, et al. "Association of the FTO Gene With BMI." Obesity 16, no. 4 (2008): 902–4. http://dx.doi.org/10.1038/oby.2007.126.

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14

Ciocâltea, Roxana. "FTO gene and its impact upon obesity." Dietetician.ro 2, no. 2 (2023): 12. http://dx.doi.org/10.26416/diet.2.2.2023.8279.

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15

Abd Ali, A. H., O. V. Bocharova, T. P. Shkurat, M. A. Shkurat, and M. A. Amelina. "Association of Ser447Ter polymorphisms of the LPL gene and rs9939609 of the FTO gene with obesity in children and adolescents in the Rostov-on-Don population." Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology, no. 2 (2021): 119–27. http://dx.doi.org/10.17072/1994-9952-2021-2-119-127.

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The aim of this study was to study the correlation between the Ser447ter (C-G) polymorphisms of the LPL gene and rs9939609 of the FTO gene and obesity in children and adolescents of the Rostov region (Russia). A case-control study examined the relationship between the rs9939609 polymorphisms of the FTO gene and Ser447Ter (S447X) of the LPL gene with obesity in 520 children and adolescents of both sexes aged 3 to 18 years: the main group consisted of 370 obese children and adolescents, and the control group - 150 children and adolescents without obesity. Genotyping of polymorphisms T / A rs9939

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16

Xu, Zi-Yang, Xia Jing, and Xing-Dong Xiong. "Emerging Role and Mechanism of the FTO Gene in Cardiovascular Diseases." Biomolecules 13, no. 5 (2023): 850. http://dx.doi.org/10.3390/biom13050850.

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Анотація:

The fat mass and obesity-associated (FTO) gene was the first obesity-susceptibility gene identified through a genome-wide association study (GWAS). A growing number of studies have suggested that genetic variants of FTO are strongly associated with the risk of cardiovascular diseases, including hypertension and acute coronary syndrome. In addition, FTO was also the first N6-methyladenosine (m6A) demethylase, suggesting the reversible nature of m6A modification. m6A is dynamically deposited, removed, and recognized by m6A methylases, demethylases, and m6A binding proteins, respectively. By cata

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17

Yuzbashian, Emad, Golaleh Asghari, Catherine B. Chan, et al. "Dietary Fatty Acid Composition Is Associated with FTO Gene Expression in Human Visceral and Subcutaneous Adipose Tissues." Current Developments in Nutrition 4, Supplement_2 (2020): 1706. http://dx.doi.org/10.1093/cdn/nzaa063_104.

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Abstract Objectives The fat mass and obesity-associated gene (FTO) is a functional candidate gene for type 2 diabetes mellitus (T2DM) and metabolic syndrome, based on evidence from genome-wide association studies (GWAS) that linked it to obesity and metabolic disorders. The FTO gene regulates energy expenditure and intake. We aimed to determine how fatty acid species measured in plasma and dietary intake associate with FTO gene expression in subcutaneous and visceral adipose tissues. Methods In this study, 97 participants aged ≥18 years were selected from patients admitted to the hospital for

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18

Stratigopoulos, George, Stephanie L. Padilla, Charles A. LeDuc, et al. "Regulation of Fto/Ftm gene expression in mice and humans." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 294, no. 4 (2008): R1185—R1196. http://dx.doi.org/10.1152/ajpregu.00839.2007.

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Two recent, large whole-genome association studies (GWAS) in European populations have associated a ∼47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear. We examined expression of these genes in organs of mice segregating for monogenic obesity mutations, exposed to underfeeding/overfeeding, and to 4°C. Fto/ Ftm expression was reduced in mesenteric adipose tissue of mice segregating for the A y , Lep ob, Lepr db , Cpe fat, or tub mutations, and there was a similar trend in other tissues. These effe

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19

Melnik, Bodo C., Ralf Weiskirchen, Wolfgang Stremmel, Swen Malte John, and Gerd Schmitz. "Risk of Fat Mass- and Obesity-Associated Gene-Dependent Obesogenic Programming by Formula Feeding Compared to Breastfeeding." Nutrients 16, no. 15 (2024): 2451. http://dx.doi.org/10.3390/nu16152451.

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It is the purpose of this review to compare differences in postnatal epigenetic programming at the level of DNA and RNA methylation and later obesity risk between infants receiving artificial formula feeding (FF) in contrast to natural breastfeeding (BF). FF bears the risk of aberrant epigenetic programming at the level of DNA methylation and enhances the expression of the RNA demethylase fat mass- and obesity-associated gene (FTO), pointing to further deviations in the RNA methylome. Based on a literature search through Web of Science, Google Scholar, and PubMed databases concerning the dieta

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20

ČERNOŠA, Iva, Žan PIRC, and Andrej RENČELJ. "Vpliv SNP znotraj FTO in LEP gena na prirast telesne mase pri govedu." Acta agriculturae Slovenica 108, no. 1 (2016): 17. http://dx.doi.org/10.14720/aas.2016.108.1.3.

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Body mass gain in a certain time period is one of the most important parameters in beef production. Some candidate genes, which have major impact on growth traits, are known from the literature, notably among them the FTO (fat mass and obesity-associated) and LEP (leptin) locus. In our experiment, we assessed the frequency of alleles at two polymorphic sites within the FTO gene (FTO6 and FTO10) and at polymorphic site in the LEP gene in a sample of Aberdeen Angus (AA) and Holstein Friesian (HF) breeds. In a larger sample, containing dairy and beef cattle breeds we tested the association of the

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21

Nasibulina, E. S., R. R. Shagimardanova, A. V. Borisova, and I. I. Ahmetov. "The association of the FTO gene polymorphism with overweight in russian population." Kazan medical journal 93, no. 5 (2012): 823–26. http://dx.doi.org/10.17816/kmj1720.

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Aim. To investigate the association of the first intron of FTO (fat mass and obesity associated) gene T/A (rs9939609) polymorphism and overweight in Russian population. Methods. 107 (females 48, males 59) overweight (body mass index 25.0-29.9 kg/m2) subjects or subjects with obesity (body mass index ≥30 kg/m2) were included. The control group (body mass index ≤24.9 kg/m2) consisted of 453 subjects (females 323, males 130). Genotyping for the T/A (rs9939609) polymorphism of the FTO gene was performed by polymerase chain reaction (PCR) and restriction enzyme digestion. Results. The frequency of

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22

Sitek, Aneta, Iwona Rosset, Dominik Strapagiel, Małgorzata Majewska, Lidia Ostrowska-Nawarycz, and Elżbieta Żądzińska. "Association of FTO gene with obesity in Polish schoolchildren." Anthropological Review 77, no. 1 (2014): 33–44. http://dx.doi.org/10.2478/anre-2014-0003.

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Abstract The goal of the study was verification of fat mass and obesity-associated (FTO) gene polymorphisms as significant risk factors of obesity in the population of Polish children. Body mass index (BMI) and DNA were evaluated, where DNA was extracted from saliva, collected from 213 children at the age of 6-13 years. DNA was genotyped by PCR (polymerase chain reaction) and HRM (high resolution melting) techniques, as well as by direct sequencing. Three (3) FTO polymorphisms were identified: rs9939609, rs9926289 and rs76804286, the last polymorphism located between the first two. For the fir

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23

Özturan Şirin, Ayçıl, and Yasemin Akdevelioğlu. "The relationship of energy-restricted diet with FTO and MC4R gene polymorphism in patients with polycystic ovary syndrome." Cukurova Medical Journal 49, no. 3 (2024): 580–91. http://dx.doi.org/10.17826/cumj.1447513.

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Purpose: The aim of this study was to determine whether the effects of an energy-restricted diet on overweight/obese patients with PCOS on body composition and biochemical parameters in groups with MC4R rs17782313 and FTO rs9939609 polymorphisms differ from those without gene polymorphism. Materials and Methods: A total of 48 women aged 18-45 were accepted. An 8-week diet intervention was applied, and anthropometric measurements, biochemical parameters and food consumption of the patients were determined before and after the intervention. In addition, FTO gene rs9939609 and MC4R gene rs1778231

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24

Sutikno, Sutikno, Rudy Priyanto, Cece Sumantri, and Jakaria Jakaria. "Identifikasi Keragaman Gen FTO Pada Bangsa Sapi Potong Indonesia." Jurnal Ilmu dan Teknologi Peternakan Tropis 6, no. 2 (2019): 232. http://dx.doi.org/10.33772/jitro.v6i2.5655.

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ABSTRAK Gen FTO berfungsi sebagai regulasi homeostasis, deposisi lemak dan pengaturan obesitas. Penelitian ini bertujuan untuk mengidentifikasi polimorfisme SNP g.125550A>T di ekson 3 gen FTO pada bangsa sapi potong Indonesia. Sampel darah diperoleh dari 209 ekor sapi, terdiri atas sapi bali (44), madura (20), Pesisir (20), katingan (20), Peranakan ongole (PO) (22), Pasundan (20), Sumba Ongole (SO) (11), brahman (20), simental (15), dan limousin (18). Polimorfisme gen FTO dianalisis menggunakan metode PCR-RFLP (HpyCH4III) dan direct sequencing. Hasil genotiping SNP g.125550A>T adalah pol

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25

Fischer, Julia, Linda Koch, Christian Emmerling, et al. "Inactivation of the Fto gene protects from obesity." Nature 458, no. 7240 (2009): 894–98. http://dx.doi.org/10.1038/nature07848.

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26

Tran, B. N. H., N. D. Nguyen, J. R. Center, J. A. Eisman, and T. V. Nguyen. "Contributions of the FTO gene to fracture risk." Bone 44 (May 2009): S19. http://dx.doi.org/10.1016/j.bone.2009.01.042.

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27

Zhang, Bao, Ya Zhang, Liangzhi Zhang, Jing Wang, Zhuanjian Li, and Hong Chen. "Allelic Polymorphism Detected in the Bovine FTO Gene." Molecular Biotechnology 49, no. 3 (2011): 257–62. http://dx.doi.org/10.1007/s12033-011-9400-z.

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28

Meyre, D. "Is FTO a type 2 diabetes susceptibility gene?" Diabetologia 55, no. 4 (2012): 873–76. http://dx.doi.org/10.1007/s00125-012-2478-4.

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29

Choudhry, Zia, Sarojini M. Sengupta, Natalie Grizenko, et al. "Association between obesity-related gene FTO and ADHD." Obesity 21, no. 12 (2013): E738—E744. http://dx.doi.org/10.1002/oby.20444.

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30

Pasala, Ajay Ratan, Tanvir Hassan, Nicolas Pineault, and Harinad Maganti. "Fat Mass Obesity-Associated (FTO) Driven Gene Regulatory Networks Control Hematopoietic Stem Cell Expansion and Homing." Blood 144, Supplement 1 (2024): 2652. https://doi.org/10.1182/blood-2024-200374.

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Hematopoietic stem cell (HSC) transplantation is the only known curative therapy for several hematological disorders, however high doses are required for long-term success. We previously optimized cocktails of stem cell agonists that promote greater expansion of HSCs compared to single agonists such as UM171 and StemReginin 1 (SR1). Limited dilution transplant assay revealed that the lead cocktail X2A promoted 15- and 4-fold expansions of scid repopulating cells, when compared to non-cultured cells or cells expanded with the combination of UM171 and SR1. RNA-seq experiments identified several

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31

Rahayu, Amalia Puji, Tety Hartatik, Agung Purnomoadi, and Edy Kurnianto. "Association of single nucleotide polymorphisms in the fatty acid synthase, LOC514211, and fat mass and obesity-associated genes with milk traits in Indonesian-Holstein dairy cattle." July-2019 12, no. 7 (2019): 1160–66. http://dx.doi.org/10.14202/vetworld.2019.1160-1166.

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Aim: The study aimed to identify fatty acid synthase (FASN), LOC514211, and fat mass and obesity-associated (FTO) gene polymorphisms and to investigate their associations with milk traits in an Indonesian-Holstein dairy cow population. Materials and Methods: A total of 100 Indonesian-Holstein cows consisting of 50 heads (0th generation; G0) and 50 heads of their daughters (1st generation; G1) were used. Polymerase chain reaction-restriction fragment length polymorphism was performed to genotype three single nucleotide polymorphisms: rs41919985 in the FASN gene, rs42688595 in the LOC514211 gene

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32

Asuquo, Edeke Affiong, Okwesilieze Fred Chiletugo Nwodo, Anosike Chioma Assumpta, Uchendu Nene Orizu, Okoro Nkwachukwu Oziamara, and Odiba Arome Solomon. "FTO gene expression in diet-induced obesity is downregulated by Solanum fruit supplementation." Open Life Sciences 17, no. 1 (2022): 641–58. http://dx.doi.org/10.1515/biol-2022-0067.

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Abstract The Fat Mass and Obesity-associated (FTO) gene has been shown to play an important role in developing obesity, manifesting in traits such as increased body mass index, increased waist-to-hip ratio, and the distribution of adipose tissues, which increases the susceptibility to various metabolic syndromes. In this study, we evaluated the impact of fruit-based diets of Solanum melongena (SMF) and Solanum aethiopicum fruits (SAF) on the FTO gene expression levels in a high-fat diet (HFD)-induced obese animals. Our results showed that the mRNA level of the FTO gene was downregulated in the

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33

S.T., Raza, Abbas S., Ahmad A., Ahmed F., Zaidi Z.H., and Mahdi F. "Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India." Balkan Journal of Medical Genetics 17, no. 1 (2014): 47–54. http://dx.doi.org/10.2478/bjmg-2014-0027.

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Abstract Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world and India has the world’s largest number of diabetic subjects. The present study was carried out to investigate the association of glutathione-S-transferase (GSTM1, GSTT1) and fat mass and obesity associated (FTO) gene polymorphisms with T2DM patients and controls, and its role in increasing the susceptibility to T2DM. A total of 198 subjects (101 T2DM patients and 97 controls) participated in this study. GSTM1, GSTT1 and FTO gene polymorphisms in the patients and controls were evaluated by polymerase ch

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Kim, Hyunjoon, Soohyun Jang, and Young-suk Lee. "The m6A(m)-independent role of FTO in regulating WNT signaling pathways." Life Science Alliance 5, no. 5 (2022): e202101250. http://dx.doi.org/10.26508/lsa.202101250.

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FTO and ALKBH5 are the two enzymes responsible for mRNA demethylation. Hence, the functional study of FTO has been focused on its mechanistic role in dynamic mRNA modification, and how this post-transcriptional regulation modulates signaling pathways. Here, we report that the functional landscape of FTO is largely associated with WNT signaling pathways but in a manner that is independent of its enzymatic activity. Re-analyses of public datasets identified the bifurcation of canonical and noncanonical WNT pathways as the major role of FTO. In FTO-depleted cells, we find that the canonical WNT/β

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Greere, Daniela, Sara Haydar, Florin Grigorescu, et al. "Fine-Scale Haplotype Mapping Reveals an Association of the FTO Gene with Osteoporosis and Fracture Risk in Postmenopausal Women." Genes 15, no. 9 (2024): 1152. http://dx.doi.org/10.3390/genes15091152.

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Introduction. The Fat Mass and Obesity-Associated (FTO) gene encodes a demethylase, which modulates RNA N6-methyladenosine (m6A) and plays a regulatory role in adipocyte differentiation and the pathogenesis of human obesity. Methods. To understand the potential role of FTO in osteoporosis (OP), we investigated five single nucleotide variations (SNVs) in intron 1 (rs8057044, rs8050136, rs9939609, rs62033406, and rs9930506) of the FTO gene, and a missense SNV i.e., rs3736228 (A1330V), located in exon 18 of the LRP5 gene, in a cohort of postmenopausal women (n = 188) from Central Europe. Genotypi

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Tao, X., X. M. Men, B. Deng, and Z. W. Xu. "Effects of breed, postnatal development, and nutrition on mRNA expression of the FTO gene in porcine muscle and its relationship with intramuscular fat deposition." Czech Journal of Animal Science 58, No. 8 (2013): 381–88. http://dx.doi.org/10.17221/6905-cjas.

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The effects of breed, development, and nutrition on mRNA expression of the fat mass and obesity-associated gene (FTO) and its relationship with intramuscular fat (IMF) content in porcine muscle (m. longissimus dorsi; m.l.d.) were estimated. Purebred Jinhua, Zhongbai, Yorkshire, Duroc, Duroc &times; Zhongbai (DZ), and Duroc &times; Yorkshire &times; Landrace (DYL) pigs were used to investigate the effect of breed. Pigs weighing 2.5, 10, 20, 40, 60, and 100 kg were selected to study the effects of different stages of development. To study the effect of nutrition, four diets were sele

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Chen, Xuefen, Yong Gao, Xiaobo Yang, Haiying Zhang, Zengnan Mo, and Aihua Tan. "Relationship of FTO gene variations with NAFLD risk in Chinese men." Open Life Sciences 15, no. 1 (2020): 860–67. http://dx.doi.org/10.1515/biol-2020-0081.

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AbstractBackgroundFat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aims to investigate the relationships of FTO gene variations with NAFLD risk in a Chinese male population.MethodsA 1:2 matched case–control study was performed on 275 cases of NAFLD and 550 controls matched for age. Nine of the FTO gene single nucleotide polymorphisms (SNPs) were genotyped.ResultsLogistic regression analysis found that FTO rs1477196 was significantly associated with the susceptibility t

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Najjar, Mahmoud. "Relationship Between Gene Polymorphism and Type 2 Diabetes in a Palestinian Population: A Study of Five Gene Polymorphisms." American Journal of Clinical Pathology 152, Supplement_1 (2019): S136. http://dx.doi.org/10.1093/ajcp/aqz126.005.

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Abstract Objectives To investigate the association between KCNQ1 rs2237892, KLF14 rs972283, ZBED3 rs4457053, COL8A1 rs792837, and FTO rs8050136; gene polymorphisms; and T2DM in the male Palestinian population. Methods In this case-control study, 100 T2DM male patients and 100 control men were examined. The two groups were genotyped for the five gene polymorphisms using restriction fragment length polymorphism–PCR (RFLP-PCR) and allele-specific (AS-PCR) techniques. Body mass index (BMI), glycated hemoglobin (HbA1c), insulin (C-peptide), total cholesterol, triglycerides, high-density lipoprotein

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Evans, Cassandra, Jason Curtis, and Jose Antonio. "FTO and Anthropometrics: The Role of Modifiable Factors." Journal of Functional Morphology and Kinesiology 7, no. 4 (2022): 90. http://dx.doi.org/10.3390/jfmk7040090.

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Numerous gene variants are linked to an individual’s propensity to become overweight or obese. The most commonly studied gene variant is the FTO single nucleotide polymorphism. The FTO risk allele is linked with increased body mass, BMI and other lifestyle factors that may perpetuate an individual’s risk for obesity. Studies assessing eating behaviors, eating preferences, nutrition interventions and other lifestyle factors were reviewed. These studies demonstrated a clear difference in eating behaviors and preferences. Lifestyle modifications including physical activity and diet were effective

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Tiwari, A., S. M. Krzysik-Walker, and R. Ramachandran. "Cloning and characterization of chicken fat mass and obesity associated (Fto) gene: fasting affects Fto expression." Domestic Animal Endocrinology 42, no. 1 (2012): 1–10. http://dx.doi.org/10.1016/j.domaniend.2011.08.001.

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Ameliyanovich, Maxim D., Maxim L. Lushchyk, Irma B. Mosse, and Larisa I. Danilova. "Association between the FTO polymorphic variants and obesity in the Belarusian population." Global Translational Medicine 2, no. 2 (2023): 352. http://dx.doi.org/10.36922/gtm.352.

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Overweight and obesity refer to the abnormal and excessive deposition of adipose tissue in the human body causing significant harm to health. Unfortunately, there has always been a persisting upward trend in the number of overweight people. The development of obesity may be caused by a combination of excessive food intake, low physical activity, and a hereditary predisposition to it. Studies of the genotypes of obese individuals allowed identifying a number of polymorphic variants of genes that contribute to a genetic predisposition to an excessive weight gain. One of the most significant pred

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Song, Yongyan, Henry Wade, Bingrui Zhang, et al. "Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome." Nutrients 15, no. 12 (2023): 2643. http://dx.doi.org/10.3390/nu15122643.

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Childhood metabolic syndrome (MetS) is prevalent around the world and is associated with a high likelihood of suffering from severe diseases such as cardiovascular disease later in adulthood. MetS is associated with genetic susceptibility that involves gene polymorphisms. The fat mass and obesity-associated gene (FTO) encodes an RNA N6-methyladenosine demethylase that regulates RNA stability and molecular functions. Human FTO contains genetic variants that significantly contribute to the early onset of MetS in children and adolescents. Emerging evidence has also uncovered that FTO polymorphism

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Ganeff, Ingeborg M. M., Maxime M. Bos, Diana van Heemst, and Raymond Noordam. "BMI-associated gene variants in FTO and cardiometabolic and brain disease: obesity or pleiotropy?" Physiological Genomics 51, no. 8 (2019): 311–22. http://dx.doi.org/10.1152/physiolgenomics.00040.2019.

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Obesity is a causal risk factor for the development of age-related disease conditions, which includes Type 2 diabetes mellitus, cardiovascular disease, and dementia. In genome-wide association studies, genetic variation in FTO is strongly associated with obesity and has been described across different ethnic backgrounds and life stages. To date, much work has been devoted on determining the biological mechanisms via which FTO affects body weight regulation and ultimately contributes to age-related cardiometabolic and brain disease. The main hypotheses of the involved biological mechanisms incl

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Souza Junior, Mauro Lúcio Ferreira, Jaime Viana de Sousa, and João Farias Guerreiro. "Analysis of coding variants in the human FTO gene from the gnomAD database." PLOS ONE 17, no. 1 (2022): e0248610. http://dx.doi.org/10.1371/journal.pone.0248610.

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Single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene reported in 2007 continue to be the known variants with the greatest effect on adiposity in different human populations. Coding variants in the FTO gene, on the other hand, have been little explored, although data from complete sequencing of the exomes of various populations are available in public databases and provide an excellent opportunity to investigate potential functional variants in FTO. In this context, this study aimed to track nonsynonymous variants in the exons of the FTO gene in different population groups

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Ruiz Díaz, María Stephany, Diana Mena-Yi, Doris Gómez- Camargo, and Gustavo José Mora-García. "Interaction analysis of FTO and IRX3 genes with obesity and related metabolic disorders in an admixed Latin American population: a possible risk increases of body weight excess." Colombia Medica 53, no. 2 (2022): e2044874. http://dx.doi.org/10.25100/cm.v53i2.4874.

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Background: Fat Mass and Obesity-related (FTO) has been one of the genes consistently related to common obesity. Single nucleotide polymorphisms (SNPs) in FTO have been linked with the IRX3 gene. Aim: This study was designed by testing the hypothesis that: i) common SNPs in FTO and IRX3 are associated with obesity and related disorders; ii) there is significant linkage disequilibrium between both genes. Methods: A cross-sectional study was carried out on the Colombian Caribbean Coast. Anthropometric and biochemical variables were measured, and obesity and metaboli

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Oyeyemi, Bolaji Fatai, Charles Ayorinde Ologunde, Ayonposi Bukola Olaoye, and Nanfizat Abiket Alamukii. "FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population." Journal of Obesity 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/3245270.

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Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect. However, this is poorly understood in Nigeria due to scarce studies. We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria. FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls. Anthropometrics and environmental variables we

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Sulis, Simona. "Učinak varijante gena FTO (rs17817449) i menopauze na krvni tlak u hipertenzivnih i normotenzivnih žena u Slovačkoj." Collegium antropologicum 47, no. 4 (2023): 279–86. http://dx.doi.org/10.5671/ca.47.4.4.

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This cross-sectional study examines the effect of fat mass and obesity-associated gene polymorphism (FTO) and menopause on blood pressure in Slovak midlife women. We assessed a total of 575 women ranging in age from 39 to 65 years. Data were analyzed using the univariate analysis of covariance to test the effect of risk FTO gene variant (G allele) and menopausal status (MS) on blood pressure in the hypertensive (HT) and normotensive (NT) women groups. A significant association was recorded between studied FTO gene variant and DBP (diastolic blood pressure) but only in HT women group (p = 0.044

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Fu, Ganglan, Shibin Du, Tianfeng Huang, et al. "FTO (Fat-Mass and Obesity-Associated Protein) Participates in Hemorrhage-Induced Thalamic Pain by Stabilizing Toll-Like Receptor 4 Expression in Thalamic Neurons." Stroke 52, no. 7 (2021): 2393–403. http://dx.doi.org/10.1161/strokeaha.121.034173.

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Background and Purpose: Hemorrhage-caused gene changes in the thalamus likely contribute to thalamic pain genesis. RNA N 6 -methyladenosine modification is an additional layer of gene regulation. Whether FTO (fat-mass and obesity-associated protein), an N 6 -methyladenosine demethylase, participates in hemorrhage-induced thalamic pain is unknown. Methods: Expression of Fto mRNA and protein was assessed in mouse thalamus after hemorrhage caused by microinjection of Coll IV (type IV collagenase) into unilateral thalamus. Effect of intraperitoneal administration of meclofenamic acid (a FTO inhibi

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Doaei, S., M. gholamalizadeh, A. Mosavi Jarrahi, M. Badakhanian, and R. Najafi. "The IRX3 gene; the missing link between the fto gene and obesity." Clinical Nutrition 37 (September 2018): S266—S267. http://dx.doi.org/10.1016/j.clnu.2018.06.1937.

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Geyik, Filiz, Neslihan Çoban, Berna Yüzbaşıoğulları, et al. "Gene-Gene Interaction between APOA4 and FTO for Obesity in TARF Study." Journal of the American College of Cardiology 62, no. 18 (2013): C53. http://dx.doi.org/10.1016/j.jacc.2013.08.160.

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