Дисертації: "Future progression"

1

Tran, Tony, and Mats Levin. "Blockchain, the future opportunity for trading progression?" Thesis, KTH, Data- och elektroteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-208956.

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The rapid expansion of computer technology have forced several business sectors to integrate with the continuous development of techniques in order to assist them in various tasks. Many fields have happily embraced the technology implementing it in numerous ways, however the development speed have proven difficult to keep up with. The insurance industry have struggled with ridding themselves of old and monolithic legacy systems with a haphazard construction. These systems are costly, cumbersome and often reliant on a “third party” centered structure creating such flaws as data leaks and monopolisation. Blockchain is a distributed ledger operating over a peer-to-peer basis, with the intention to unshackle contemporary system from their dependence towards central authorities. Additionally, the peer-to-peer architecture introduced a new form of transparency which differs from contemporary solutions used in centralised systems, beyond the peer-to-peer architecture, the blockchain also incorporated consensus algorithms, allowing peers to verify one another to achieve consensus regarding the validity of each block. This resulted in a "trustless system" considering no single party in the community is dependent on the credibility of a central authority. In order for the blockchain technology to be applicable on the market it must overcome obstacles such as privacy and the new EU data protection regulation “General protection data regulation”. However a vague definition of personal data have caused ambiguity which appears to be irreconcilable with the blockchain technology. Research have therefore shifted its focus to explore opportunities for the technology to collaborate with techniques from centralisation in order to overcome its obstacles.
Datorteknologins hastiga expansion har bidragit till att mängder av olika yrkessektorer tvingats integrera teknologin i sin dagliga verksamhet för att bidra med vissa uppgifter. Då teknologin i stor utsträckning har varit till nytta har många yrkesgrupper välkomnat den, dock har teknikens utvecklingshastighet visats vara mycket hög vilket medfört viss problematik. Försäkringsbranschen har visats ha problem med att hantera vidareutvecklingen av sina gamla monolitiska “legacy” system då de är både utdaterade och konstruerade på ett ostrukturerat sätt. Dessa gamla system är kostsamma, svårhanterliga och baseras ofta på en systemarkitektur centrerad kring “tredje parter” detta medför problem som dataläckor och monopolisation. Blockkedjan är ett distribuerat journalsystem som struktureras med ett peer-to-peer nät som bas. Detta görs med förhoppningen att kunna frigöra existerande system från centrala autentiseringsparter. Dessutom har blockkedjan introducerat en ny sorts transparens som skiljer sig från de nuvarande centrala systemen. Blockkedjan inkluderar också consensus algoritmer som medför att alla deltagare kan verifiera varrandra och därmed nå ett uniformt beslut om blocks validitet. Dessa egenskaper resulterar i ett system som inte är beroende av att dess användare behöver lita på en centraliserad tredje part. För att blockkedjan ska vara användbar och framgångsrik på en öppen marknad finns vissa funktionskrav som måste uppfyllas. Ett av de främsta av dessa är EU förordningen “General protection data regulation”. Problem har uppstått då “General protection data regulation” innefattar vaga definitioner av “personlig data”, dessutom är de existerande tolkningar av konceptet svår applicerade för blockkedje tekniker. Detta har bidragit till att utvecklingen av rena blockkedje lösningar har stagnerat och utvecklingen dirigerats om till forskning inom hybrid teknologier som inkluderar tekniker från centraliserade system.

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2

Farrell, Mark Andrew. "Enterprise risk management : maturity progression, value creation & future evolution." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706462.

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It is critical to determine whether ERM creates value to ensure that the significant resources deployed in ERM programmes result in tangible corporate value. This thesis analyses the valuation implications of ERM maturity using The Risk and Insurance Management Society Risk Maturity Model (RIMS RMM) data collected from 2006 to 2011 using a 5-point maturity scale. The results, measured by Tobin’s Q, suggest that firms that have reached mature levels of ERM exhibit higher firm values, demonstrating a statistically significant positive relation to the magnitude of 25 percent. Upon decomposition of the maturity score, the most meaningful aspects of ERM relate to top-down executive engagement and the resultant cascade of ERM culture throughout the firm. In addition to serving as one of the first studies to establish strong empirical evidence for ERM increasing firm value, the thesis extends its contribution to examine the firm performance implications of ERM maturation under different models, specifically identifying characteristics that engender or inhibit the aforementioned valuation implications. A discussion of how an ERM programme could significantly affect an organisation’s policies and relationship with stakeholders is also explored. ERM is theoretically projected to be a means to help strengthen the relationship that companies have with regulators, reinforce or repair relationships with shareholders, strengthen interactions with supply chain stakeholders, enhance reputational relations with clients and improve auditor partnerships. The thesis concludes by arguing that ERM has now reached a critical mass, such that further adoption and development of the ERM discipline is now inevitable.

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3

Paluszcyk, Chana Renee. "The Future of Myasthenia Gravis: Exploring the Onset, Progression and Implications of Disease." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613371.

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Myasthenia gravis (MG) is an autoimmune disease whose name means "grave muscular weakness". MG is a rare disease affecting only 200-400 persons per million and the characteristic symptoms include muscle weakness, particularly in highly active voluntary muscles. MG affects the neuromuscular junction in an antibody-mediated manner, resulting in impaired nerve-muscle cell communication in affected individuals. Specifically, two main proteins are targeted: nicotinic acetylcholine receptors (ACh receptors) and a muscle-specific tyrosine kinase (MuSK). Previous studies have discovered the mechanism of MG pathogenesis but the exact mechanisms which cause the failure to maintain self-tolerance have not been discovered. Based on current knowledge of MG, this paper will explore potential causes of the disease and provide numerous hypotheses directed at future research opportunities.

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4

Baker, Elizabeth Rosemary. "Approaches to disease progression modelling for identifying predictors of future cognitive decline in dementia." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/approaches-to-disease-progression-modelling-for-identifying-predictors-of-future-cognitive-decline-in-dementia(07cd08df-14f3-4232-9ee8-1830a1bd4ff8).html.

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Dementia progression is characterised by a lengthy pre-symptomatic phase, where pathology may be accumulating, followed by a more rapid decline evidenced by onset of clinical symptoms and eventually functional impairment. The rate of decline in symptoms from cognitive impairment to dementia greatly varies between individuals, complicating prognosis and the assessment of much needed disease-modifying drugs. As a result there is a huge demand for greater understanding of the between-subject variability in progression and a need to understand biomarkers and risk factors for predicting future cognitive decline. In cohorts derived from two of the largest NHS foundation trust mental health service providers in the UK and multiple Alzheimer’s cohorts, this thesis explores methods for modelling disease progression and investigates the relationship between blood based proteins, genetic variants, health indicators and potential repurposing medications with cognitive decline. Through applying approaches that tackle three areas that require consideration for modelling of cognitive decline and disease progression, this thesis identified associations of antidepressant medication and psychotic symptoms associated with faster cognitive decline in dementia, in two separate cohorts.

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5

Collins, Samantha Lillian. "What future worlds of work do women executives aspire to and how might they be accomplished? : an exploratory study within banking and professional service companies in London and New York." Thesis, London Metropolitan University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499579.

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6

Rocha, Franciane. "Future Present Progressive in Brazilian Portuguese." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for språk- og kommunikasjonsstudier, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-20022.

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The use of the present progressive to express future is a grammatical construction imported into Portuguese from English. In this construction here called Future Present Progressive (FPP), the verbal predicate expresses the present tense, while a temporal adverb locates the event in the future. The assimilation of this construction to Brazilian Portuguese (BP) enriches the language’s inventory of periphrastic expressions of the future tense. This work studied the internal structure of FPP constructions in BP and the relationship between its components. Lexical and grammatical aspects were considered to investigate why utterances such as: ‘Estamos nos mudando em duas semanas’ (We are moving in two years) are grammatical, while utterances as: ‘*Estou morando no Candá ano que vem’ (*I am living in Canada next year) are not, although both expressions are grammatical in the present progressive in BP. The research was conducting with naturally occurring language, collected from the Twitter microblogging service, using a methodology, which one might call digital linguistics. The data was treated using the resources of the multi-lingual database TypeCraft, and is freely available at: http://typecraft.org/TCEditor/1730/. Our analysis of FPPs focuses on the relationship between lexical and grammatical aspect and suggests an extension of the semantic features that define different aspects. It furthermore highlights the role that the stage-level predicate ‘estar’ plays in deriving the semantics of this construction. Our research suggests that, besides the combination between lexical and grammatical aspect, different semantic mechanisms can also influence the compatibility pattern of verbs and syntactic constructions. Our research also shows that the FPP, although a borrowing from English, has morphosyntactic and semantic properties that makes it an integral part of the BP grammar.

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7

Lunguinho, Marcus Vinicius da Silva. "Verbos auxiliares e a sintaxe dos domínios não-finitos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/8/8139/tde-19062012-134154/.

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Esta tese oferece uma análise para os verbos auxiliares em geral e para os auxiliares do português em particular. A nossa proposta é a de caracterizar universalmente os verbos auxiliares como uma classe de elementos verbais que apresentam as seguintes propriedades: pertencem à categoria verbal, apresentam um traço verbal não-valorado [uV], não atribuem papel temático e compõem, juntamente com o verbo principal, um mesmo domínio oracional. A presença do traço [uV] na estrutura dos verbos auxiliares tem como consequência o fato de esses verbos selecionarem uma projeção verbal como complemento. Dentro dessa projeção estará o alvo que vai valorar esse traço não-interpretável por meio da operação Agree (Chomsky 2000, 2001). A postulação dessas quatro propriedades nos permitiu a derivação de critérios de auxiliaridade, uma reinterpretação dos critérios comumente propostos na literatura. Com esse trabalho, chegamos a uma lista de oito critérios necessários e suficientes para a definição de um verbo como auxiliar no português. Da aplicação desses critérios resultou a composição dos membros da classe dos verbos auxiliares do português: ser, ter, estar e ir. Para a análise das passivas, foi adotado o sistema de derivação por smuggling, sugerido por Collins (2005) e o auxiliar ser foi analisado como um verbo funcional que valora o traço [perfectivo] do particípio passivo. Apontamos para a existência de um outro tipo de passiva, as passivas não-canônicas, que apresentam como traço característico a presença do verbo auxiliar ter. Argumentamos que esse verbo é um produto computacional que resulta da combinação dos traços do auxiliar ser com os traços do núcleo funcional v*. Na análise dos auxiliares ter perfectivo e estar progressivo, adotamos uma postura decomposicional, tal como proposta por Kayne (1993), que deriva esses verbos a partir da incorporação de elementos preposicionais aos traços de um verbo auxiliar abstrato. Com isso, temos três verbos auxiliares que resultam da computação sintática: o auxiliar passivo ter, que é a realização dos traços [vSER v*], o auxiliar perfectivo ter, que realiza os traços [vAUX PDEPOIS] e o verbo auxiliar progressivo estar, cujo conjunto de traços inclui [vAUX PDENTRO]. Por fim o auxiliar ir é tratado como um núcleo modal que, em combinação com os traços do núcleo T, gera a interpretação de futuro.
This dissertation puts forward an analysis of auxiliary verbs in general, and of Portuguese auxiliary verbs in particular. The proposal is to universally characterize auxiliary verbs as a class of verbal elements which (i) belong to the verbal category ; (ii) have a unvalued verbal feature [uV] ; (iii) do not assign theta roles ; and (iv), together with the main verb, compose one single phrasal domain. The presence of [uV] guarantees that the auxiliary verb will select a verbal projection as its complement, within which is the target that will value the uninterpretable [uV] feature by means of the operation Agree (Chomsky 2000, 2001). The four characteristics proposed to describe auxiliary verbs allowed for the derivation of criteria of auxiliarity, a reinterpretation of the criteria usually discussed in the literature. Eight necessary and sufficient criteria define an auxiliary verb in Portuguese. The composition of THE Portuguese auxiliary class with its four members ser, ter, estar and ir resulted from the application of these eight criteria. Passives were analysed by means of the smuggling system, proposed by Collins (2005) and the auxiliary ser was considered to be a functional verb which values the [perfective] feature of the passive participle. A non-canonical passive was found to co-exist with canonical passives, one which shows the auxiliary ter. We argue that ter is the computational product of features of the auxiliary ser with features of the functional node v*. For the analysis of perfective ter and progressive estar, we have adopted a decompositional view along the lines of Kayne (1993), which derives these verbs from the incoporation of prepositional elements to the features of an abstract auxiliary verb. So, three of the Portuguese auxiliary verbs result from syntactic computation: passive ter is the manifestation of the features [vSER - v*]; perfective ter is the manifestation of the features [vAUX - PDEPOIS]; and progressive estar includes the features [vAUX - PDENTRO]. And the auxiliary verb ir is treated as a modal head, which, when combined with features of the head T, generate a future reading.

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8

Fletcher, Johnston Meaghen. "See my future : future thinking of adolescents with a progressive life-threatening neurodegenerative illness." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43712.

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The construction of meaningful future self-representations is an important part of identity development. For adolescents living with a progressive life-threatening neurodegenerative illness, the projection of self into the future requires the movement into the unknown and uncertain realm of an illness trajectory. The purpose of this study was to examine how adolescents who are living with a progressive life-threatening neurodegenerative illness construct meaningful future self-representations. A narrative approach was utilized as the method of inquiry. Ten adolescents between the ages of 12 and 20 who had been diagnosed with a progressive life-threatening neurodegenerative illness participated in a semi-structured narrative interview. Within the interviews three lines of inquiry were followed, which explored future thinking, possible selves, and continuity in the stories of the selves over time. Data analysis occurred across four readings of the narrative transcripts. The analysis included a stepping-in and stepping-back process, allowing for individual stories to remain contextualized and for collective themes to emerge across the narratives. Major findings confirm future thinking as a contextually based activity, a construction of a range of possible selves both with and without the illness, and an ability to oscillate between these two versions of future selves. As well, the adolescents demonstrated personal continuity in the selves of the past, present, and the future. As an overarching theme, future thinking emerges as a required activity for reasons of coping, personhood, and decision-making. This research makes contributions to developmental science as well as pediatric palliative care as it extends current literature pertaining to future thinking and possible selves, thereby adding to the conceptual and theoretical knowledge base. As well, the findings highlight the importance of developing a healthcare practice that is responsive to the developmental need to create a future self and to explore all aspects of what is possible, as well as impossible.

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9

Salvatori, Paul. "Autonomy and the Future." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20274.

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This thesis introduces the idea of progressive autonomy, namely future-oriented self-governance, based on the pursuit of desired goals that one has established for oneself. As the thesis shows, focus on this sort of activity, as well as its value and importance, has been largely left out of the existing literature on autonomy. In contrast, this activity is central to progressive autonomy, which, as this thesis puts forth, enables the individual to actively determine the course of his life. Throughout the process, the individual is author of his own narrative, which, as the ongoing fulfillment of desired goals, he experiences as both meaningful and worthwhile. The thesis does not frame the narrative of the progressively autonomous individual as merely a story or an account of events. Rather, it does so as a sequence events the progressively autonomous individual is directly responsible for bringing about, as well as concretely situated in. He is, in other words, part and parcel of his narrative, as opposed to, say, a novelist who physically stands apart from the events he imagines and writes. Finally, the thesis demonstrates that, though the progressively autonomous individual is motivated by his own desires, he is more than just a pleasure seeker; he is strategically morally responsible. Such responsibility involves and is characterized by rejecting certain motives that undermine the actual achievement of desired goals, while affirming other motives that facilitate this achievement. This, as the thesis shows, renders the progressively autonomous individual more responsible than one who partakes in this rejection or affirmation, without regard to how either will impact one’s future.

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10

Luciaková, Katarína. "Architektúra a nevidiaci." Doctoral thesis, Vysoké učení technické v Brně. Fakulta architektury, 2010. http://www.nusl.cz/ntk/nusl-233222.

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This thesis explores the relationship between architecture and the blind people. For better clarity and understanding of the topic, The work has been divided into five distinctive parts. In the first, introduction part, I approach space sensation of a blind person from the physiological and psychological angle. This analysis is very important for the understanding of imagination, which the blind person has. Another important fact to understand is the way in which the blind person gets the information about the space and what is his ability to process it. Further, I explain the basic principles of the blind person’s movement through space and describe instructions of how to help blind people in the concrete spatial situations. In the next part, I give a short information about the historical progress of the relation between the society and the blind people. An important fact is that, as late as 200 years ago, the blind people were considered as “sub men” and did not have the full freedom privilege. This relation has been modified over time and nowadays, the blind people have the freedom of movement and all the rights to enjoy their lives. To meet the needs of the blind people, many associations have been created that act on their behalf. The associations have different modes of functioning, but their common goal is to help blind people with their social rehabilitation, looking for employment and removing architectural barriers. The core of my work is divided into two parts. In the first one, I focus on the problematic of the blind people and architecture from the functional aspect. The functional aspect is vital for the blind people. It corresponds to their safety in the environment. In this chapter, I treat in detail basic elements for designing buildings, for specifying barriers and principles of design for blind people. Furthermore, I describe the help tools the blind people need in order to move in the space. I evaluate the future of these tools and indicate the rapid technological progression which makes the life of blind people more comfortable. In the next part, I focus on the problematic of the blind people and architecture from the aesthetic aspect. This question has not been much explored yet, but is, nonetheless, very important. In this part of my work, I use more my personal experience and the knowledge coming from the exploration of space. Aesthetical values are subjective for all the people, with or without a handicap. Therefore, in this final chapter, I try to note the facts that can be used in the process of the aesthetical perception and to reflect on them. In the domain of aesthetical research, there also exist tools and institutions that help blind people in their comprehension of architecture. The division of my work emerged from the compilation of diverse facts in the process of writing. This thesis has an informative and practical character. It is intended for people who want to understand and to be informed about how to design architecture for the blind people. It will be directed towards people who build this kind of architecture and need an overview of how to make it. It is also intended for people interested in learning more about architecture.

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11

Bastos, JosÃ RomÃrio Rodrigues. "Natureza, Tempo e TÃcnica: Thomaz Pompeu de Souza Brasil e o SÃculo XIX." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10673.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
On peut affirmer que, pendant le XIXÃme siÃcle, CearÃ a vÃcu profondes transformations qui ont changÃ sa dynamique sociale, culturelle, Ãconomique. La crÃation des institutions, comme le Liceu do CearÃ et la DiocÃseduCearÃ, le dÃplacement Ãconomique de Aracati Ã Fortaleza, dÃ au progrÃs agricole, dâentre autres ÃvÃnements, ont rÃvÃlÃ que la province commenÃa Ã mettre en pratique son projet de modernisation, essayant faire partie du programme de construction de la nation, commencÃ aprÃs lâIndependence.Thomaz Pompeu de Sousa Brasil a ÃtÃ insÃrÃ dans ce contexte, collaborant effectivement avec lÂindication de projets et leur approbation. Son activitÃ a eu lieu aussi dans le champ politique, agissant comme leader de parti libÃral cearense, dÃputÃ et sÃnateur. Dans cette ambiance dâaffirmation des idÃes, le cearense a cru que la sortie plus efficace pour rÃussir le progrÃs Ãtait le mode comme la sociÃtÃ utilisait la nature. Ainsi, il sâest dÃdiÃ Ã lancer des mesures qui proportionnaient de faÃon raisonnable lâutilisation des ressources naturelles en visant le dÃveloppement Ãconomique de sa province. Ã travers les articles de journal, discours politiques et publications de livres, on a exposÃ sa pensÃe en relation Ã la nature, sa fonction pour la sociÃtÃ et ce quâon devait Ãtre fait pour assurer sa prÃservation sans nuire la course pour la modernitÃ. Cette Ãtude a comme but entendre la confrontation des idÃes Ã propos des tentatives modernisant dans lesquelles la nature a apparu comme un important ÃlÃment de discussion, ayant comme point de dÃpart les indications laissÃes par Thomaz Pompeu.
Pode se afirmar que durante o sÃculo XIX o CearÃ viveu profundas transformaÃÃes que alteraram sua dinÃmica social, cultural e econÃmica. A criaÃÃo de instituiÃÃes, como o Liceu do CearÃ e a Diocese do CearÃ, o deslocamento econÃmico de Aracati para Fortaleza, entre outros acontecimentos, revelaram que a provÃncia comeÃara a colocar em prÃtica seu projeto de modernizaÃÃo, tentando fazer parte do programa de construÃÃo da naÃÃo, iniciado apÃs a independÃncia.Thomaz Pompeu de Sousa Brasil esteve inserido dentro desse contexto, colaborando efetivamente tanto na indicaÃÃo de projetos quanto na aprovaÃÃo, uma vez que sua atividade tambÃm se deu no campo polÃtico, atuando como chefe do partido liberal cearense, deputado geral e senador. Nesse clima de afirmaÃÃo de ideias, o cearense acreditou que a saÃda mais eficaz para o alcance do progresso era o modo como a sociedade utilizava a natureza. Assim sendo, dedicou-se a lanÃar medidas que proporcionassem de forma racional o uso dos recursos naturais tendo em vista o desenvolvimento econÃmico de sua provÃncia. AtravÃs de artigos em jornal, pronunciamentos polÃticos e publicaÃÃes de livros, deixou expresso seu pensamento em relaÃÃo a natureza; qual a funÃÃo dela para a sociedade e o que deveria ser feito para garantir sua preservaÃÃo sem prejudicar a corrida pela modernidade. O Presente trabalho tem por objetivo entender como se deu o embate de ideias em torno das tentativas modernizadoras em que a natureza apareceu como importante elemento de discussÃo, tendo como ponto de partida as indicaÃÃes deixadas por Thomaz Pompeu.

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12

Brackenbury, Anne (Anne Elizabeth) Carleton University Dissertation International Affairs. "Grafting onto the future: the Canadian autoworkers' struggle to advance a progressive post-fordist mode of regulation." Ottawa, 1992.

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13

Silva, Sara Pascoal. "Progressos recentes e perspectivas futuras dos compostos metálicos com actividade anti-tumoral." Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3552.

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Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
A elevada incidência das doenças oncológicas na população portuguesa e mundial e a mortalidade por elas causada, fazem com que estas sejam um importante problema de saúde pública nos dias de hoje. Devido aos efeitos adversos resultantes da terapêutica medicamentosa actual, os estudos desenvolvidos no sentido de encontrar moléculas com propriedades e características mais vantajosas têm sido cada vez mais frequentes. No entanto, é necessário comprovar tais características inovadoras, bem como a máxima segurança na sua utilização. A cisplatina (cis-diaminodicloroplatina (II)) é um fármaco utilizado, em muitos casos, no tratamento de vários tipos de tumores e neoplasias. No entanto, tal uso é limitado pela resistência que se cria e pelos efeitos adversos que esta molécula causa, sendo os mais frequentes a neurotoxicidade e a nefrotoxicidade. O presente trabalho monográfico visa reunir as mais recentes investigações e descobertas acerca da molécula da cisplatina e dos seus derivados, dando a conhecer todos os aspectos físico-químicos, farmacológicos e terapêuticos relacionados com os mesmos. Os derivados da cisplatina, já aprovados para o tratamento do cancro serão apresentados e debatidos, bem como outros análogos que, por motivos descritos, abandonaram o estatuto de possíveis fármacos anticancerígenos. Compreender-se-á o mecanismo de acção desta molécula, responsável pela sua actividade anti-tumoral, no tratamento dos mais diversos tipos de cancro e conhecer-se-ão os efeitos secundários consequentes do seu uso. Outro objectivo deste trabalho é referir os progressos recentes no desenvolvimento de análogos da cisplatina. The mortality caused by the ever increasing cancer diseases in the Portuguese and Global population is an important public health problem in our days. Studies conducted to find molecules with more advantageous properties and characteristics have been increasing, due to the adverse effects of current drug therapy. It is necessary to ensure that this research produces results with innovative characteristics and maximum safety. Cisplatin (cis-diamminedichloroplatinum II) is the drug used most to fight oncological diseases. Use of cisplatin is limited by resistance to the drug and adverse effects that this molecule causes (neurotoxicity and nephrotoxicity). This monograph brings together the latest research and discoveries on the molecule of cisplatin and its analogues; presenting all aspects of physical, chemical, pharmacological and therapeutic issues related to it. The analogues of cisplatin that are already approved for the treatment of cancer will be presented, as well as others that were excluded due to resistance of the drug and /or adverse effects. The analysis will show the mechanism of action this molecule utilizes during treatment of several types of cancer; also displaying the side effects resulting from its use. Another goal of this work is to point out the recent progresses in the development of cisplatin analogues.

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14

Bailey, Kendall Lyons. "The Future of the Tea Party: A Comparison of the Progressive (Bull Moose) Party and the Tea Party Movement." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/34569.

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The Tea Party Movement (TPM) has emerged as an important player in United States politics by promoting fiscal conservatism, limited government, free market economics, and Constitutionalism. Candidates championing these TPM values have had some successful campaigns, particularly in the 2010 congressional primary and general elections. In doing so, TPM candidates focused their attacks on President Obama and his supporters in Congress, drawing attention to the increase in government spending and the growing budget deficit. The niche focus of the TPM combined with the strength of the U.S. two-party system and votersâ partisan loyalties may limit the long-term effectiveness of the group. An analysis of campaign rhetoric from a sample of successful TPM House candidates highlights similarities in language used by the sampled TPM candidates in conveying TPM values. The discussion of similar economic and political climates of the Progressive (Bull Moose) Party and the Tea Party Movement eras provides for a historical comparison from which to predict the future of the TPM. In sum, this thesis suggests that the Tea Party Movement will likely expire with an improved economy and the conclusion of Barack Obamaâ s presidency.
Master of Arts

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15

Gomes, Dayse Benigna Bernardo Araujo. "O Programa Nacional de Cooperação Acadêmica-Novas Fronteiras : avaliação de progresso e oportunidades para o futuro." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/32271.

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O Brasil tem sido desafiado a enfrentar questões estratégicas e complexas nas atividades de ciência, tecnologia e inovação que demandam a formação de redes de pesquisa e Pós-graduação orientadas à redução das disparidades acadêmicas regionais. Conforme proposto na 4ª Conferência Nacional de Ciência, Tecnologia e Inovação de 2010, há necessidade de desenvolver metodologias adequadas à avaliação de redes de pesquisa e Pós-graduação como a forma mais avançada de produção do conhecimento e formação de pessoal qualificado, sobretudo para desenvolver Programas de Pós-graduação nas áreas estratégicas e nas tecnologias portadoras de futuro. Nesta dissertação, são apresentados resultados e estatística descritiva da consulta endereçada aos coordenadores de projetos para avaliar o progresso do Programa Nacional de Cooperação Acadêmica - Novas Fronteiras (2007). A metodologia foi de natureza qualitativa, por meio de questões abertas propostas na consulta, comparando com os pareceres da Comissão Julgadora que julgou a renovação dos projetos. Foram também mapeadas as Instituições com potencial para liderar a formação de redes de pesquisa em áreas estratégicas e tecnologias portadoras de futuro, conforme indicadas no Livro Azul da 4ª CNCTI, mediante verificação de ocorrências no Diretório de Grupos de Pesquisa do Conselho Nacional de Desenvolvimento Científico e Tecnológico (DGP/CNPq) e de cursos recomendados pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes), com conceitos iguais ou superiores a cinco, com potencial para liderar redes cooperativas mais amplas. Teve finalidade exploratória para avaliar os resultados parciais do Procad NF Edição 2007 e investigar sobre o potencial de formação de redes de pesquisa e Pós-graduação. Ainda não foi possível avaliar os impactos desta edição do Programa, porque sua implantação é muito recente e não houve tempo suficiente para maturação dos projetos. A fundamentação teórica que serviu de base para a avaliação foi encontrada na produção científica mais recente relacionada às redes de cooperação acadêmica e nos documentos disponíveis na Capes.
Brazil has been challenged to face strategic and complex issues concerning science, technology and innovation which demand the constitution of research and graduate programs networks in order to reduce regional academic inequalities. According to the Fourth National Conference of Science Technology and Innovation (2010) there is a need to develop adequate methodologies to assess research networks to improve the scientific production and formation of qualified researchers specially for strategic fields of knowledge and advanced technologies. In this dissertation the results of an inquiry for project coordinators are presented with the purpose to assess the progress of the National Program of Academic Cooperation - New Frontiers, Edition 2007, because it is not yet possible to assess its impacts considering the short time of its implementation. The results and descriptive statistics of a consult addressed to project coordinators are presented for progress assessment of the National Program of Academic Cooperation - New Frontiers (2007). The methodology for assessment was of qualitative nature, including comparison with de assessments by the Committee of Specialists which recommended the renewal of projects. Institutions were mapped with potential for constitution of cooperative networks with focus on strategic areas and advanced technologies as indicated by the Blue Book from the 4th CNCTI through searches in the Directory of Research Groups (DGP) of National Council for Scientific and Technological Development (CNPq) matched with the graduate programs recommended by Brazilian Federal Agency for Support and Evaluation of Graduate Education (Capes) with grades equal or greater than five with network leadership potential. It was also exploratory on its goals to investigate the potential of formation of research and graduate programs networks. The theoretical basis of the present research was of academic cooperation networks.

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Langaro, Jiani Fernando. "Quando o futuro é inscrito no passado: colonização e pioneirismo nas memórias públicas de Toledo-PR (1950-2010)." Pontifícia Universidade Católica de São Paulo, 2012. https://tede2.pucsp.br/handle/handle/12758.

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Made available in DSpace on 2016-04-27T19:30:39Z (GMT). No. of bitstreams: 1 Jiani Fernando Langaro.pdf: 28438498 bytes, checksum: 049a871424108d74ccade7d7f01c62c9 (MD5) Previous issue date: 2012-10-26
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
This work intent to establish some relationships between history and memory considering the ideas of colonization and pioneering disseminated in Toledo-PR, during 1950 to 2010. Trough this ideas were scattered many versions about a colonization private enterprise, achieved on Paraná West between 1940 and 1950, as a mark in history from local and regional past and as genesis of a fortunate journey which would raise a city in continuous progress . Such versions generally emphasizes just a few participations, like the ones connected to colonialist industries and clergy or southerner migrants which were European descendants, and keep in secret the negatives effects of that project, and this thought was accepted with no strings for some areas in local academic historiography. Initially, the hypothesis was that those memories grew from somewhere in the city, probably spread by some stiffs and social groups through institutions and projects, hypothesis that later on was proved. Having this as beginning point, and basing on social history knowledge, the target turn into the study of how these memories were established and became hegemonics in that place, the different elements emerged from wrangles and any other ways to explain the local past. In this way, drawing heavily on sources like recolection literature, printing press, schoolbooks, monuments and spaces on the city or on entities that studied local past, many cultural and educational projects created by the public authorities and independent initiatives turned questionable. From this point, it is possible to certify that in Toledo existed a battlefield for the past in which city foundation memories acquired centrality and became groundwork to picture the future. More than this, such wrangles involved local academic historiography its own and make clear that history and memories were attached to social reality. Through oral narratives it was also observed that in the admission of these memories the inhabitants did not just absorb than, but reflected and elaborated it again, this is what makes possible to perceive the existence of hegemonic versions, but not unique, about Toledo and Paraná West past
O trabalho discute as relações entre história e memória a partir das temáticas da colonização e do pioneirismo veiculadas em Toledo-PR, entre 1950 e 2010. Através desses temas foram difundidas versões que tratavam um empreendimento privado de colonização , realizado na região oeste do Paraná entre as décadas de 1940 e 1950, como marco histórico do passado local e regional e como gênese de uma trajetória venturosa que teria gerado um município em contínuo progresso . Tais versões, geralmente enfatizavam apenas a participação de alguns sujeitos, como aqueles ligados às empresas colonizadoras e ao clero, além dos migrantes sulistas de ascendência europeia e silenciavam sobre os impactos negativos desses processos, o que acabou sendo incorporado sem maiores críticas por determinadas tendências da historiografia acadêmica regional. Inicialmente, a hipótese era de que tais memórias não surgiam espontaneamente na cidade, mas eram difundidas por determinados sujeitos e grupos sociais através de instituições e projetos, o que logo pôde ser confirmado. Diante disso, com base nos conhecimentos de história social, o objetivo passou a ser o estudo de como essas memórias se instituíram e se tornaram hegemônicas no lugar, os elementos díspares que emergiram dessas disputas e as outras formas existentes de se explicar o passado local. Assim, com base em fontes como literatura memorialística, a imprensa, livros didáticos, esculturas, monumentos e os próprios espaços da cidade e de entidades voltadas ao trabalho com as memórias locais, foram problematizados diferentes projetos culturais e educacionais promovidos pelo poder público e iniciativas independentes dos moradores. A partir disso, foi constatado que em Toledo existia um campo de disputas pelo passado, no qual as memórias da formação do município adquiriram centralidade e tornaram-se elemento basilar para desenhar o futuro. Mais do que isso, tais disputas acabaram envolvendo a própria historiografia acadêmica regional e o que foi evidenciado é que história e memória não eram campos separados da realidade social. Através do recurso às narrativas orais, também foi observado que na recepção dessas memórias, os moradores da cidade não as absorviam simplesmente, mas as refletiam e reelaboravam, o que fez perceber a existência de versões hegemônicas, porém não únicas, sobre o passado de Toledo e do oeste do Paraná

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Head, Nicholas. "Development of a multi-criteria, GIS-based, backcasting framework model (G-BFM) for progression towards zero waste futures, for holistic resource management policy and practice in Northamptonshire by 2050." Thesis, University of Northampton, 2015. http://nectar.northampton.ac.uk/9131/.

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The complex nature of waste management and planning requires a long-term strategic policy formation approach incorporating sustainable development principles. Consequently, the transition from a waste paradigm to valuing materials as resources is central for transitioning towards a 'zero waste' future. A need is identified, via infrastructure planning, to move beyond short-term forecasting and predictive methods previously used in waste research in order to overcome target-driven decision-making. The application of a participatory backcasting methodology: visioning, baseline assessment, scenario development and feasibility testing; produced transformative scenarios which are visualised using GIS reflecting the choices, ideas and beliefs of participants. The structural governance (e.g. waste infrastructure planning and strategic waste policy) of an English county is used to evaluate the efficacy of waste management scenarios. A quantitative model was developed to test scenarios for three metrics (tonnages, economics and carbon). The final model utilises the synergy between backcasting and GIS to spatially and temporally analyse empirically quantified outputs. This structured approach produced three transformative scenarios and one reference scenario. Waste prevention and changes to systemic waste generation produced long-term tonnage reductions across the transformative scenarios. Costs of future waste management witnessed the reference scenario outperforming one of the transformative scenarios; while the highest emissions savings were attributable to the scenario most closely reflecting the notion of 'deep sustainability'. In terms of waste infrastructure planning, a centralised pattern of large integrated facilities emphasising catchments rather than administrative boundary were most effective. All three transformative scenarios surpassed the 90% recycling and recovery level used as the zero waste benchmark. The research concludes that backcasting can offer a range of potential futures capable of achieving an arbitrary definition of zero waste. Further, these futures can be visualised and analysed via GIS; enhancing stakeholder engagement. Overall, the GIS-based Backcasting Framework Model (G-BFM) produced has the potential to benefit a range of stakeholders and practitioners and is strategically scalable.

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Ouchi, Hideyasu. "Idiopathic pulmonary fibrosis: pathogenesis, progression, treatments, and future prospects." Thesis, 2019. https://hdl.handle.net/2144/38685.

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Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease of unknown etiology, in which excessive accumulation of scar tissue in the interstitial spaces of the lung obstruct normal pulmonary function. Currently, the only curative treatment is lung transplantation. While pharmaceutical therapeutics have been recently approved for use in IPF in 2014, they are still unable to provide a truly curative treatment. While genetic risk factors have been identified, the most commonly occurring mutation is only detected in approximately 38% of IPF patients, leaving an uncertainty in the very existence of a common genetic factor in IPF. Cigarette smoke and other environmental particulates have been significantly linked to the diagnosis of IPF, implicating an initial immunological response to trigger the pathogenesis of IPF. Nintedanib, a potent tyrosine kinase receptor inhibitor was first developed in 1998 as a candidate for cancer treatment. Investigation of its effects in fibrosis in the past few decades has led to a significant discovery of its application in IPF. Nintedanib significantly inhibits the fibrotic activity of fibrotic myofibroblasts in the lungs by inhibiting signaling cascades necessary for cell proliferation and progression of the disease. However, nintedanib falls short in that it cannot fully inhibit the advancement of the disease and mortality rates of IPF still remain high. Pirfenidone, the other currently available pharmaceutical therapeutic, was discovered in 1976 as a potent inhibitor of inflammation. Subsequent experiments further reviled its potency as an anti-fibrotic drug. After decades of research, pirfenidone’s mechanism of antifibrotic characteristics were revealed as a potent inhibitor of fibrocyte recruitment and chemotaxis, and as an inhibitor of transcription growth factor beta (a growth factor heavily implicated in the activity of myofibroblasts) mediated pathways. However, like nintedanib, pirfenidone fails as a curative treatment, only delaying the progression of the disease. In the search for new molecular targets for pharmaceutical therapy, forkhead box M1 (FOXM1), programmed cell death protein-1 (PD-1), and prostaglandin E2, have been identified to play a mediatory role in many of the pathways involved in myofibroblast activity. Many of these targets have also been identified in other disease models such as cancer and immunological inflammatory disease. Avasimibe has been recently identified as a potent inhibitor of aldo-ketoreductase through a FOXM1 mediated pathway. Its molecular mechanism in osteosarcoma cancer disease model may prove to be a novel pharmaceutical therapeutic for IPF. BI 853250, a novel focal adhesion kinase (FAK) inhibitor also demonstrates potential to be a new pharmaceutical therapeutic for IPF patients. Exploring signaling pathways that involve these newly found targets and collaborative research with cancer and immunological diseases shows promise in providing steps to cure IPF in the future.

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Craft, Gregory. "Predicting future bone loss using a new progression rate index for the diagnosis and monitoring of untreated periodontitis." 1996. http://catalog.hathitrust.org/api/volumes/oclc/48170127.html.

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Wang, Austin H. "Predicting future bone loss using a new progression rate index for the diagnosis and monitoring of the treated periodontitis." 1996. http://catalog.hathitrust.org/api/volumes/oclc/46942001.html.

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Dao, Tien Dung. "The Effects of Hypnosis on Flow and Putting Performance in Golfers." Thesis, 2019. https://vuir.vu.edu.au/39602/.

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Csikszentmihalyi (1975) introduced the flow concept, involving total absorption in the task, confidence, and control, with effortless, automatic movement. Flow has nine dimensions that Stavrou and Zervas (2004) divided into five antecedents (challenge-skill balance, clear goals, unambiguous feedback, total concentration on the task, sense of control) and four concomitant dimensions (action-awareness merging, loss of self-consciousness, time transformation, and autotelic experience). Loss of self-consciousness and time transformation have similarities to phenomena often reported in hypnotic trance states. To examine whether the experience of these phenomena in hypnosis enhanced flow state, I performed three studies. In Study 1, I evaluated whether a hypnotic state facilitates flow and enhances performance via its concomitant dimensions and whether the trancework component of traditional hypnosis (TH), compared with neutral hypnosis (NH), is crucial, with 20 golfers, who performed putting under controlled conditions. In Study 2, I examined the effect of two hypnosis techniques, regression (RE) and future progression (FP) on golf putting performance and flow state with 25 golfers. Both studies had the same structure. I used the Waterloo-Stanford Group C Scale of Hypnotic Susceptibility (WSGC) to match participants into conditions. Golfers performed 56 4m test putts at pre-test and post-test. I measured radial error of each putt and number of putts holed. Then they completed the Flow State Scale-2 (FSS-2) at pre- and post-test. All participants undertook a 60-minute, face-to-face session, then listened to a recording of that session for seven days with different hypnotic suggestions in the RE and FP conditions. In Study 1, two-way mixed-design ANOVA revealed that TH reduced radial error and two dimensions of flow, sense of control and loss of self-consciousness, compared with NH. In Study 2, two-way mixed design ANOVA showed that the effect of FP was significantly larger than the effect of RE in facilitating global flow mainly due to the time transformation dimension, but performance was not enhanced. In Study 3, I investigated the effect of FP on flow and putting performance in competitions. Three male golfers participated in a single-case design (SCD) study, comprising six competition rounds in the Baseline Phase (BP) and six rounds in the Intervention Phase (IP). I recorded number of putts per round, percentage distance error, strokes gained putting, global flow state, and flow dimensions. Visual inspection and split-middle technique analysis of individual graphs indicated improvement in performance and flow of two golfers. I used narrative analysis to examine social validation questionnaire responses. Participants reported superior performance with more confidence and greater concentration after the hypnosis intervention. The findings of these three studies indicate that RE and FP hypnosis can be useful techniques to promote flow and improve performance. Further study is warranted to identify the most effective combination of hypnosis techniques to enhance, global flow state, flow dimensions, and performance.

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Shen, Yi-Wen, and 沈怡彣. "《Progressive Path》The Journey of Past, Now and Future." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/qj99fb.

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Ferreira, Sofia Helena de Jesus Moreira. "Terapêutica farmacológica na Doença de Alzheimer: progressos e esperanças futuras." Master's thesis, 2012. https://repositorio-aberto.up.pt/handle/10216/72411.

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Ferreira, Sofia Helena de Jesus Moreira. "Terapêutica farmacológica na Doença de Alzheimer: progressos e esperanças futuras." Dissertação, 2012. https://repositorio-aberto.up.pt/handle/10216/72411.

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Zarife, Natalia de Azevedo. "Terceirização, progresso ou retrocesso? O futuro das relações de trabalho diante do atual cenario mundial." Master's thesis, 2017. http://hdl.handle.net/10316/84146.

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Dissertação de Mestrado em Direito apresentada à Faculdade de Direito
O presente estudo tem por objetivo analisar o fenômeno da terceirização no ordenamento jurídico brasileiro traçando um breve paralelo com a situação do trabalho temporário em Portugal, determinando seu alcance, suas limitações e sua finalidade, bem como, buscando concluir, ao final, se a contratação terceirizada pode ser considerada uma forma de modernização do direito trabalhista, ou se, ao revés, estar-se-ia precarizando os já escassos direitos do trabalhador. Para alcançarmos o objetivo final a que se pretende com a pesquisa atual, mister se faz analisar o cenário econômico atual, a crise mundial e a tão especulada necessidade de flexibilização e até mesmo de desregulamentação dos direitos trabalhistas.Atualmente, como é sabido, muitos especialistas, sobretudo os que perfilham a uma corrente neoliberal, acusam a suposta rigidez da legislação laboral do fracasso e colapso do sistema capitalista, sem atentarem-se, contudo, para a grande vilã deste cenário, que é a busca desenfreada pelo lucro. Isso porque, para se alcançar uma conclusão racional acerca da existência de progresso ou retrocesso da contratação terceirizada (ou temporária, como no ordenamento jurídico português), é de suma relevância entender as circunstâncias de sua criação, bem como a evolução histórica das relações de trabalho, tendo como certo que as normas jurídicas devem evoluir junto com a sociedade, sob pena de se tornarem, por fim, meras palavras mortas e ineficazes, capazes de engessar toda uma coletividade. Objetiva-se, ademais, através de uma reflexão racional, concluir acerca da valorização social do trabalhador frente ao mercado capitalista globalizado que motiva a terceirização flexibilizada, não perdendo de vista o ser humano como sujeito de direito a uma vida digna e não apenas como uma mercadoria.
The purpose of this study is to analyze the phenomenon of outsourcing in the Brazilian legal system by drawing a brief parallel with the situation of temporary work in Portugal, determining its scope, its limitations and its purpose, as well as seeking, in the end, whether hiring Can be considered as a form of modernization of labor law, or if, on the other hand, the already scarce worker rights would be precarious. In order to reach the final objective of the current research, it is necessary to analyze the current economic scenario, the world crisis and the so speculated need for flexibilization and even deregulation of labor rights. Today, as is well known, many experts, especially those who follow a neoliberal trend, accuse the supposed rigidity of labor legislation of the failure and collapse of the capitalist system, without, however, paying attention to the great villain of this scenario, which is the Unbridled search for profit. This is because, in order to arrive at a rational conclusion about the existence of progress or retreat from outsourced contracting (or temporary, as in the Portuguese legal system), it is of great importance to understand the circumstances of its creation, as well as the historical evolution of labor relations , With the certainty that legal norms must evolve along with society, under penalty of becoming, in the end, mere words dead and ineffective, capable of engulfing a whole collectivity. It is also intended, through a rational reflection, to conclude about the social valorization of the worker in front of the globalized capitalist market that motivates a flexibilization outsourcing, not losing sight of the human being as subject of right to a life worthy and not just as a merchandise.

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Lourenço, André Joaquim Constante. "Relatórios de estágios e Monografia intitulada "Estratégias Farmacológicas da Doença de Alzheimer: progressos e desafios futuros"." Master's thesis, 2017. http://hdl.handle.net/10316/83662.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia
Descrita pela 1ª vez em 1906, a Doença de Alzheimer é uma doença neurodegenerativa crónica, progressiva e potencialmente letal. Trata-se da causa mais comum de demência, sendo que os sintomas característicos desta doença incluem perda de memória, alterações comportamentais, dificuldades na linguagem e incapacidade de realizar as atividades do dia-a-dia.Os últimos anos trouxeram uma mudança de paradigma no que diz respeito aos mecanismos fisiopatológicos que estão na base da doença. Além das placas senis de peptídeo β-amiloide e das tranças neurofibrilares de proteína Tau, a inflamação crónica, o stress oxidativo e a deficiente metabolização de glucose apresentam-se como fatores importantes que contribuem para a progressão da doença. A área do diagnóstico da Doença de Alzheimer também tem sofrido sucessivas melhorias. Apesar de o diagnóstico definitivo da doença ser efetuado através de um exame histopatológico post-mortem, já é possível, através do recurso a várias técnicas complementares, efetuar um diagnóstico da doença com 90% de certeza. Atualmente, a terapêutica farmacológica disponível para a doença atua apenas ao nível da sua sintomatologia. Assim, e face ao enorme crescimento do número de doentes de Alzheimer ao longo das últimas décadas, é urgente encontrar estratégias terapêuticas que previnam, impeçam a progressão ou curem a doença. Desta forma, o presente trabalho tem como objetivo apresentar, de forma geral, as principais características da Doença de Alzheimer e evidenciar os progressos que têm sido feitos ao longo dos últimos anos na pesquisa de novas opções terapêuticas para a mesma.
Described for the first time in 1906, Alzheimer's Disease is a chronic, progressive and potentially lethal neurodegenerative disease. It is the most common cause of dementia, and the characteristic symptoms of this disease include loss of memory, behavioral changes, language difficulties and inability to perform daily activities.The last few years have brought about a paradigm shift with regard to the pathophysiological mechanisms underlying the disease. In addition to the Aβ peptide senile plaques and Tau protein neurofibrillary tangles, chronic inflammation, oxidative stress, and poor glucose metabolism are key contributors to disease progression. The area of diagnosis of Alzheimer's Disease has also undergone successive improvements. Although the definitive diagnosis of the disease is only possible through a post mortem histopathological examination, it is possible, through the use of several complementary techniques, to make a diagnosis of the disease with 90% certainty. Currently, the pharmacological therapy available for the disease only affects its symptomatology. Thus, and in view of the increase in people suffering from dementia over the last decades, it is urgent to find therapeutic strategies that prevent, stop the progression or cure the disease. Thus, the present work aims to present the main characteristics of Alzheimer's Disease and to highlight the progress that has been made over the last years in the research of new therapeutics for it.

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Ribeiro, Ana Bárbara Valente. "Mobile learning for corporate training in Portugal: current challenges and future directions." Master's thesis, 2019. http://hdl.handle.net/10071/19813.

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Currently, the workforce is becoming more and more global and diversified, raising new challenges to the corporate training area. Technological progress has created new opportunities to tackle these challenges, one of them, the diffusion of mobile-learning. However, academic research has been focused on studying this type of learning only for educational purposes. This dissertation approaches how Portuguese managers perceive mobile-learning for corporate training and identifies best practices to maximize the effectiveness of these initiatives. This study applies the qualitative method, with a content analysis to seven interviews to managers of diversified activity sectors. Conclusions are presented under four main categories: General perceptions on mobile-learning; Current practices; Advantages; Limitations; Opportunities. Results show that mobile-learning is perceived as an extension of e-learning, with clear divergencies from managers on the underlined learning theories and the role of the trainee in this learning context. Nevertheless, some companies are investing in selecting adjusted technological platforms, integration new functionalities, adapting content, and processes for this specific learning context. Managers recognize the existence of several benefits and limitations associated with mobile-learning. Lastly, managers perceive possible improvements with a focus on reinforcing relationships between trainees and the creation of customized content. Additionally, they foresee the integration of new technological advancements, like augmented reality. The conclusions of the performed analysis set guidelines that describe pedagogical improvements and reinforce the need to suppress social necessities of trainees to maximize the effectiveness of existing and future mobile-learning initiatives.
Atualmente, a força de trabalho é cada vez mais global e diversificada, criando desafios para área de formação empresarial. O progresso tecnológico fomentou novas oportunidades para ultrapassar estes desafios, entre elas, a disseminação de mobile-learning. Contudo, a literatura científica foca esta forma de aprendizagem para fins educacionais. Esta dissertação aborda a forma como gestores portugueses percecionam mobile-learning na formação empresarial e identifica boas práticas para maximizar a eficácia destas iniciativas. Este estudo aplica o método qualitativo, com uma análise de conteúdo a sete entrevistas a gestores de sectores de atividade diversificados. Nesse sentido, as conclusões são apresentadas sob quatro categorias principais: Perceções gerais sobre mobile-learning; Práticas atuais; Vantagens; Limitações; e Oportunidades. Os resultados indicam que mobile-learning é percecionado como uma extensão do e-learning, com divergências sobre as correntes de aprendizagem associadas ao conceito e o papel do formando nesse contexto. Todavia, algumas empresas estão a investir na seleção de plataformas tecnológicas ajustadas, integração de novas funcionalidades, adaptação dos conteúdos, e processos para este contexto de aprendizagem. Os gestores reconhecem a existência de benefícios associados a mobile-learning, assim como realçam as suas limitações. Por fim, os gestores enunciaram possíveis melhorias com foco em fomentar relação entre os formandos e na criação de conteúdo. Adicionalmente, anteveem a integração de novos avanços tecnológicos, como a realidade aumentada. As conclusões da análise realizada estabelecem linhas orientadoras ao descrever melhorias pedagógicas e reforçar a necessidade de suprimir as necessidades sociais dos formandos para maximizar eficácia de iniciativas de mobile-learning existentes e futuras nas organizações.

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