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Дисертації з теми "Gene expression pattern"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Yu, Yu-yang Yao. "Alternative splicing pattern of the slowpoke gene /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004408.

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2

Bekele, Adane Mihret. "Gene expression and cytokine pattern of pulmonary tuberculosis patients and their contacts in Ethiopia." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71942.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: The immune response against M. tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics and interplay of different arms of the immune response and the identification of infection-stage specific biomarkers are critical to allow the development of better tools for combating tuberculosis. In an attempt to identify such biomarkers, we studied pulmonary tuberculosis patients and their contacts in Addis Ababa, Ethio

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3

Karam, Sana. "Mechanisms of pattern formation in the developing cerebellum : role for Eph receptor gene family /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/10557.

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4

Kurra, Goutham. "Pattern Recognition in Large Dimensional and Structured Datasets." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1014322308.

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5

Yagi, Shunya. "Sex and strategy use matters for pattern separation, adult neurogenesis and immediate early gene expression in the hippocampus." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54089.

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Adult neurogenesis in the dentate gyrus (DG) plays a crucial role for pattern separation and there are sex differences in the regulation of neurogenesis. Although sex differences, favoring males, in spatial navigation have been reported, it is not known whether there are sex differences in pattern separation. The current study was designed to determine whether there are sex differences in the ability for separating similar or distinct patterns, learning strategy choice, adult neurogenesis and immediate early gene (IEG) expression in the DG in response to pattern separation training. Male and f

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6

Hopitzan, Alexander A. "Expression of the Ank3 gene in rat skeletal muscle : gene structure, splice pattern, phylogenetic analysis, molecular identification and subcellular targeting of encoded ankyrins-G." Paris 6, 2005. http://www.theses.fr/2005PA066311.

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7

Desh, Heather Colleen. "MASSETER MUSCLE MYOSIN 1C GENE EXPRESSION: RELATIONSHIPS TO GROWTH FACTORS AND INFLUENCE ON FIBER-TYPE AND SKELETAL GROWTH PATTERN." Master's thesis, Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/172046.

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Oral Biology<br>M.S.<br>The presence of dentofacial deformities in humans is prevalent, with distortions in jaw growth affecting about 20% of people worldwide. Least is known about the genetic etiology of malocclusions, so it is the purpose of this study to identify genetic factors which influence jaw growth and examine how their expression correlates with vertical and sagittal malocclusions. Myostatin (MSTN) is a negative growth regulator which functions to inhibit excessive growth of muscle. Mice in which this gene was absent exhibited increased muscle mass and altered skeletal form, indicat

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8

Perry, Michael W. "Comparative evolution and development of the butterfly eyespot and a survey of wing pattern gene expression across butterfly families." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0015869.

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9

Carkacioglu, Levent. "Automated Biological Data Acquisition And Integration Using Machine Learning Techniques." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12610396/index.pdf.

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Since the initial genome sequencing projects along with the recent advances on technology, molecular biology and large scale transcriptome analysis result in data accumulation at a large scale. These data have been provided in different platforms and come from different laboratories therefore, there is a need for compilation and comprehensive analysis. In this thesis, we addressed the automatization of biological data acquisition and integration from these non-uniform data using machine learning techniques. We focused on two different mining studies in the scope of this thesis. In the first st

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10

Ayuso, Anna Maria E. "Automation of Drosophila gene expression pattern image annotation : development of web-based image annotation tool and application of machine learning methods." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/66403.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 91-92).<br>Large-scale in situ hybridization screens are providing an abundance of spatio-temporal patterns of gene expression data that is valuable for understanding the mechanisms of gene regulation. Drosophila gene expression pattern images have been generated by the Berkeley Drosophila Genome Project (BDGP) for over 7,000 genes in over 90,000 digital images. These images are currently hand cu

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11

Peralta, Angela. "Generation of A L. Hesperus embryonic cDNA library for the isolation of genes involved in early pattern formation." Scholarly Commons, 2010. https://scholarlycommons.pacific.edu/uop_etds/755.

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While development in flies is well understood, pattem formation and the evolution thereof in arachnids have yet to be clarified. Flies and other metazoans primarily use two families of genes called Hox genes and Pax genes to regulate embryogenesis. Because of the high evolutionary conservation of Hox and Pax proteins, I hypothesize that arachnids also use this system to organize their body pattern. To enable studies of the Westem black widow spider, Latrodectus hesperus, an embryonic eDNA library and a fixation protocol were developed for L. hesperus embryos. The generation of these tools will

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12

Edfeldt, Kristina. "Innate immunity in atherosclerosis : signaling pattern recognition receptors and an antimicrobial peptide /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-299-3/.

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13

Xu, Yaomin. "New Clustering and Feature Selection Procedures with Applications to Gene Microarray Data." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196144281.

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14

Elamaa, H. (Harri). "Type XVIII collagen:characterization of the primary structure and expression pattern of different variants in Xenopus laevis, characterization of the human gene structure and analysis of transgenic mice expressing endostatin." Doctoral thesis, University of Oulu, 2004. http://urn.fi/urn:isbn:9514275691.

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Abstract In this work the type XVIII collagen has been studied by using several approaches, such as different animal models. The primary structure of frog, Xenopus laevis, type XVIII collagen and the expression pattern of its variants during early embryogenesis have been elucidated. The gene structure of human type XVIII collagen was characterized and the localization and processing of its longest variant was studied by generated antibodies. In addition, the function of the proteolytically released C-terminal part of type XVIII collagen, endostatin, was studied by generating transgenic mice ex

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15

McAndrew, Patricia E. "dentification of PTP(Lambda): A Novel CNS-Specific Protein Tyrosine Phosphatase Gene That Has A Spatially Restricted Expression Pattern in The Cerebellum and Construction of a Dystrophin Minigene /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487930304688164.

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16

Aneela, Javed [Verfasser], Sieghart [Akademischer Betreuer] Sopper, Holger [Akademischer Betreuer] Reichardt, and Dieter [Akademischer Betreuer] Kube. "Gene expression pattern and functional analysis of CD8+ T cells from individuals with or without anti HIV/SIV noncytolytic activity / Javed Aneela. Gutachter: Holger Reichardt ; Dieter Kube. Betreuer: Sieghart Sopper." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1042846278/34.

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17

Cheung, Kwan-lok. "Analysis of lacZ gene expression patterns of a Hoxb3[lacZ] mouse mutant during early development /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B3508571X.

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18

Cheung, Kwan-lok, and 張君樂. "Analysis of lacZ gene expression patterns of a Hoxb3[lacZ] mouse mutant during early development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010596.

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19

Pearce, Jonathan J. H. "Murine chromobox genes and the maintenance of Hox gene expression patterns." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282013.

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20

Blanding, Carletha R. "Maize gene expression UV response patterns reveal coordinate regulation of many genes /." Electronic version (Microsoft Word), 2005. http://dl.uncw.edu/etd/2005/blandingc/carlethablanding.doc.

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21

Jonsson, Per. "Improving Clustering of Gene Expression Patterns." Thesis, University of Skövde, Department of Computer Science, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-482.

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<p>The central question investigated in this project was whether clustering of gene expression patterns could be done more biologically accurate by providing the clustering technique with additional information about the genes as input besides the expression levels. With the term biologically accurate we mean that the genes should not only be clustered together according to their similarities in expression profiles, but also according to their functional similarity in terms of functional annotation and metabolic pathway. The data was collected at AstraZeneca R&D Mölndal Sweden and the applied

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22

Turatsinze, Jean Valéry. "Développement et évaluation de méthodes bioinformatiques pour la détection de séquences cis-régulatrices impliquées dans le développement de la drosophile." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210053.

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L'objectif de ce travail est de développer et d'évaluer des approches méthodologiques pour la<p>prédiction de séquences cis-régulatrices. Ces approches ont été intégrées dans la suite logicielle<p>RSAT (Regulatory Sequences Analysis Tools). Ces séquences jouent un rôle important dans la<p>régulation de l'expression des gènes. Cette régulation, au niveau transcriptionnel, s'effectue à<p>travers la reconnaissance spécifique entre les facteurs de transcription et leurs sites de fixation<p>(TFBS) au niveau de l'ADN.<p>Nous avons développé et évalué une série d'outils bioinformatiques qui utilisent

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23

TRATTARO, SEBASTIANO. "BRAIN ORGANOID MODELLING OF HUMAN CORTICOGENESIS:THE PARADIGM OF WEAVER SYNDROME." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/875973.

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Multiple strategies of brain organoidogenesis have enabled the investigation of human cerebral corticogenesis in-vitro with increasing accuracy. However, little is yet known about how closely the gene co-expression patterns seen in brain organoids (BO) match those of fetal cortex. Here we benchmarked BO against fetal corticogenesis by integrating transcriptomes from in-house differentiated cortical BO (CBO), other BO systems, human fetal brain samples processed in-house, and pre-natal cortices from the BrainSpan Atlas. We identified and ranked co-expression patterns and hubs of corticogenesis

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24

Tan, Wooi-keng, and 陳慧卿. "Expression patterns of housekeeping genes in cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29892892.

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25

Kiss, Nimrod G. B. "DNA methylation and gene expression patterns in adrenal medullary tumors." Stockholm : Department of Molecular Medicin and Surgery, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-750-4/.

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26

King, John F. "Comparisons of gene expression patterns in progressive breast carcinoma and the adjacent stromal microenvironment." Fairfax, VA : George Mason University, 2007. http://hdl.handle.net/1920/2949.

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Thesis (M.S.)--George Mason University, 2007.<br>Title from PDF t.p. (viewed Jan. 18, 2008). Thesis directors: Donald Seto, Anna Baranova. Submitted in partial fulfillment of the requirements for the degree of Master of Science in Bioinformatics. Vita: p. 105. Includes bibliographical references (p. 100-104). Also available in print.

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27

Krause, Lauren Kendall. "Gene Expression patterns in High-Altitude Pulmonary Edema: A Gene Microway Analysis." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08152007-111828/.

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Multiple modulating genes and environmental factors have been implicated in the pathogenesis of high-altitude pulmonary edema (HAPE). However, at the present time, there exists an incomplete understanding of the molecular mechanisms and pathways which underlie constitutional susceptibility. Genome-wide measurements of gene expression in peripheral blood mononuclear cells (PBMCs) were performed using microarray technology. Comparison of gene expression profiles of HAPE-susceptible and resistant individuals resulted in the identification of several previously undescribed candidate genes. RhoA an

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28

Charoensawan, Varodom. "Evolution and dynamics of transcription factors and gene expression patterns." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609169.

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29

Tsang, Hiu-Gwen. "Investigating gene expression patterns in the mammalian cardiovascular system." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31180.

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The cardiovascular system is an essential component of mammalian biology. It is a complex network of various tissues and structures with unique functions. The function of the cardiovascular system is to supply nutrients including oxygen to the various cells, tissues and organs within the body, and remove waste products from them. Given the importance of this role, it is not surprising that there are countless regulatory mechanisms at the molecular, cellular and tissue levels that are required to support this functional system. Perturbations in parts of this system are likely to lead to abnorma

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30

Oldridge, Emma. "Gene expression patterns in human prostate stem cell differentiation." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/3804/.

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The identification of phenotypic differences between stem cells (SCs) and their more differentiated counterparts is crucial for designing novel SC-based therapeutics for prostate cancer (CaP). RARRES1 and LXN were identified as two homologous genes whose expression was highly significantly down-regulated in the SC fraction compared to more differentiated epithelial cells. The overall aim of this study was to investigate the expression, regulation and function of the SC-silenced genes RARRES1 and LXN, and their potential interacting partner CPA4 in prostate epithelial differentiation and CaP. W

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31

Carneiro, Newton Portilho 1963. "Patterns of gene expression in maize endosperm: Characterization of the eEF1A gene family." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282611.

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One of the major challenges for maize improvement is to enhance the protein quality of the endosperm. We do not know what genes encode the proteins that contribute most to the protein quality, but lysine is the most limiting amino acid. One way to determine the proteins made in the endosperm is by isolating the genes expressed in this tissue and identifying their function. The results of the maize genome project with etiolated seedling and endosperm cDNA libraries support the basis of this strategy, in that the putative functions of a large number of cDNA sequences were identified through sequ

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32

Collaudin, Samuel. "Exploration de l'origine de la robustesse de la dynamique d'expression d'AGAMOUS pendant le développement de la fleur en utilisant une approche pluridisciplinaire." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEN049/document.

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L'identité des organes floraux est définie par l’expression de gènes homéotiques appartenant à la famille des MADS-box au début du développement floral. Un de ces gènes, AGAMOUS (AG), est responsable de l’identité des étamines et des carpelles chez Arabidopsis thaliana. Dans ce manuscrit, je tente de comprendre les propriétés spatiales et temporelles de l’expression d’AG en cherchant à connaître les mécanismes impliqués dans le bon établissement de la dynamique d’expression d’AG pendant les jeunes stades du développement floral.Je débute par développer un modèle de réaction-diffusion qui prend

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33

Gower, Adam C. "Discovering biological connections between experimental conditions based on common patterns of differential gene expression." Thesis, Boston University, 2012. https://hdl.handle.net/2144/32019.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Similarities between patterns of differential gene expression can be used to establish connections between the experimental and biological conditions that give rise to them. The growing volume of gene express

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34

Di, Capua Daniele-Mario. "Differential gene expression patterns of the vasculature in scleroderma biopsies." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92385.

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35

Morien, Evan. "Characterization of gene expression patterns in the wild Pacific salmon." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43723.

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Declines in Pacific salmon stocks in recent decades have spurred much research into their physiology and survivorship, but comparatively little into their genomics. Sockeye salmon in particular are experiencing high levels of mortality during their migration upriver, and the numbers of returning sockeye have fluxuated wildly with respect to predictions in recent years. The goal of my project is to gain insight into the basic genomics of Pacific salmon stocks, including the sockeye, through bioinformatic approaches to gene expression profiling. Using microarray technology, I have conducted a la

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36

Benson, Elizabeth Anne. "Patterns and regulation of gene expression in the Drosophila testis." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432553.

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37

Sinha, Naveen Neil. "Visualizing patterns of gene expression in growing Bacillus subtilis biofilms." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11183.

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Most bacteria live in surface-attached colonies known as biofilms, which contain distinct cell types embedded in a self-produced extracellular network of polymers. Differentiation into functionally-distinct sub-populations of cells, or phenotypes, is primarily a result of nutrient availability and extracellular signals. These inputs change over time, leading to spatial and temporal patterns in the relative populations of phenotypes. Although transitions between phenotypes have been investigated in single cells, the triggers for this process within an intact biofilm are not well understood.<br>

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38

Carter, Deborah. "Analysis of differential gene expression patterns in non-Hodgkin's lymphoma." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301273.

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39

Lemieux, Jacob E. "Gene expression in P. falciparum : statistical patterns and molecular determinants." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:f6827b50-ca5f-4fe2-a52c-1947fef224ab.

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This thesis investigates patterns and mechanisms of gene expression in P. falciparum. The rapidly cycling patterns of genes during the asexual stages confounds the analysis of gene expression in culture and in patients. In order to overcome this problem, we develop statistical models to estimate the temporal progression of malaria parasites by using the observed gene expression values and known reference sets. We extend this framework to account for lineage commitment, and show that, similar to asexual development, it is also possible to recover information about parasite sexual differentiatio

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40

Li, Qihang. "Visual Analytics of Patterns of Gene Expression in the Developing Mammalian Brains." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492643127036346.

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41

Zhou, Wei. "Gene Expression Patterns in Flea Vectors of Yersinia pestis." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2490.

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Plague bacteria (Yersinia pestis) are transmitted to susceptible mammals by fleas. At least 25 flea species found in North America have been identified as plague vectors. The most efficient flea vector is the Oriental rat flea Xenopsylla cheopis, while the cat flea Ctenocephalides felis is a poor vector. The factors that determine vector competence of different fleas are not known. The main obstacles that the bacteria must overcome in the flea gut are also unknown. Fleas' molecular responses to Y. pestis invading could be a determining factor to control the bacterial survival and growth. Good

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42

Lee, Sam Chi-Hang. "Dynamic gene expression patterns during in vivo maturation of mouse hepatoblasts." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/43798.

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Hepatoblasts are bipotential fetal liver cells that differentiate into hepatocytes and cholangiocytes, the parenchymal cell types in the adult liver. While genes that regulate hepatoblast differentiation have been identified, less is known about the underlying regulatory networks. Transcriptome studies using mouse whole fetal livers have been undertaken to decipher those networks. However, as 70-80% of cells in the fetal liver are hematopoietic, the resulting transcriptome data were biased toward genes expressed in blood cells and not maturing hepatoblasts. To address this, I performed a temp

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43

Nixon, Paula. "Patterns of gene expression controlled by AP 2 in breast cancer." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271013.

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44

Haridi, Alaa Abdulgader H. "Characterisation, diversity and expression patterns of mucin and mucin-like genes in the sea anemones." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122871/3/__qut.edu.au_Documents_StaffHome_StaffGroupH%24_halla_Desktop_Alaa%20Abdulgader%20H%20Haridi%20Thesis.pdf.

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Mucin proteins provide the first line of defence against pathogens in most organisms and are being explored for their use in the pharmaceutical industry. Sea anemone species produce large amounts of mucus, but their diversity and applications have not been examined. My research demonstrated that sea anemones possess a diverse repertoire of mucin proteins, some of which will provide natural products for pharmacological, clinical and cosmetic applications.

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45

Gil, Grathwohl Karina. "Gene structure and expression patternof mouse Toll-like receptor 3." [S.l. : s.n.], 2002.

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46

LIN, Chun-Ta, and 林俊達. "Differential Gene Expression Pattern of Avian Reovirus Infection." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/51989030380155691230.

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47

"Pattern analysis of microarray data." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074754.

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DNA microarray technology is the most notable high throughput technology which emerged for functional genomics in recent years. Patterns in microarray data provide clues of gene functions, cell types, and interactions among genes or gene products. Since the scale of microarray data keeps on growing, there is an urgent need for the development of methods and tools for the analysis of these huge amounts of complex data.<br>Interesting patterns in microarray data can be patterns appearing with significant frequencies or patterns appearing special trends. Firstly, an algorithm to find biclusters w

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Chen, Emily, and 陳曉怡. "Pattern Recognition of Gene Expression Profile in Function Group." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/58004287004496613670.

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Chen, Po-Hao, and 陳伯豪. "Expression pattern of NSC1 gene in the nervous system." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/30001832635612630798.

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碩士<br>國立陽明大學<br>神經科學研究所<br>91<br>Abstract Neural stem cells are involved in neural development and are capable of generating a variety of neural cells. Previously, we used a subtractive hybridization assay, in which cDNA of embryonic day 10.5 (E10.5) rat neural tube was subtracted from cDNA of postnatal day 1 (P1) rat brain, to identify genes preferentially expressed in early neural tube. Neural stem cell marker 1 (NSC1) gene was identified in this assay and was hypothesized as a membrane receptor. In this project, I intended to detect the expression pattern of NSC1.

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Huang, Shih-Wei, and 黃世維. "Expression pattern and functional assay of zebrafish diras2 gene." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/78798485653068630811.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>102<br>Small GTPase are a family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). The most well-known members are the Ras GTPases and which sometimes called Ras superfamily GTPases. Over the past years, researchers have identified many components of the pathway that mediate Ras activation and effector function. The Ras proteins function as regulated GDP/GTP switches that cycle between active GTP-complex and inactive GDP-complex states. Additionally, Ras regulator the actin filament system, and regulate actin dynamics.Rho proteins have

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