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Готові списки джерел за темами / Glucocorticoids bioavailabilty

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Добірка наукової літератури з теми "Glucocorticoids bioavailabilty"

Автор: Grafiati

Опубліковано: 15 лютого 2025

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Статті в журналах з теми "Glucocorticoids bioavailabilty"

1

MacLeod, Clare, Patrick W. F. Hadoke, and Mark Nixon. "Glucocorticoids: Fuelling the Fire of Atherosclerosis or Therapeutic Extinguishers?" International Journal of Molecular Sciences 22, no. 14 (2021): 7622. http://dx.doi.org/10.3390/ijms22147622.

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Glucocorticoids are steroid hormones with key roles in the regulation of many physiological systems including energy homeostasis and immunity. However, chronic glucocorticoid excess, highlighted in Cushing’s syndrome, is established as being associated with increased cardiovascular disease (CVD) risk. Atherosclerosis is the major cause of CVD, leading to complications including coronary artery disease, myocardial infarction and heart failure. While the associations between glucocorticoid excess and increased prevalence of these complications are well established, the mechanisms underlying the

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2

Mitchell, Brett M., and R. Clinton Webb. "Impaired Vasodilation and Nitric Oxide Synthase Activity in Glucocorticoid-Induced Hypertension." Biological Research For Nursing 4, no. 1 (2002): 16–21. http://dx.doi.org/10.1177/1099800402004001003.

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Synthetic glucocorticoids are among the most widely prescribed medications by physicians. Although they have a vast array of beneficial effects such as immunosuppression and anti-inflammation, excess glucocorticoids can lead to iatrogenic Cushing’s syndrome, which includes hypertension and cardiovascular disease. The exact mechanism by which glucocorticoids elevate blood pressure is not completely understood, but it appears to be a complex pathology that involves increased responsiveness to vasoconstrictors and decreased vasodilator production. Nitric oxide is a vasodilator that plays a key ro

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3

Petersen, Helle Heibroch, Thomas K. Andreassen, Tilman Breiderhoff, et al. "Hyporesponsiveness to Glucocorticoids in Mice Genetically Deficient for the Corticosteroid Binding Globulin." Molecular and Cellular Biology 26, no. 19 (2006): 7236–45. http://dx.doi.org/10.1128/mcb.00400-06.

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ABSTRACT Corticosteroid binding globulin (CBG) is the carrier for glucocorticoids in plasma. The protein is believed to keep the steroids inactive and to regulate the amount of free hormone acting on target tissues (free hormone hypothesis). Here, we generated a mouse model genetically deficient for CBG to test the contribution of the carrier to glucocorticoid action and adrenocortical stress response. The absence of CBG resulted in a lack of corticosterone binding activity in serum and in an ∼10-fold increase in free corticosterone levels in CBG-null mice, consistent with its role in regulati

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4

Fowden, A. L., and A. J. Forhead. "Endocrine mechanisms of intrauterine programming." Reproduction 127, no. 5 (2004): 515–26. http://dx.doi.org/10.1530/rep.1.00033.

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Epidemiological findings and experimental studies in animals have shown that individual tissues and whole organ systems can be programmedin uteroduring critical periods of development with adverse consequences for their function in later life. Detailed morphometric analyses of the data have shown that certain patterns of intrauterine growth, particularly growth retardation, can be related to specific postnatal outcomes. Since hormones regulate fetal growth and the development of individual fetal tissues, they have a central role in intrauterine programming. Hormones such as insulin, insulin-li

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5

WIEDERSBERG, S. "Bioavailability and bioequivalence of topical glucocorticoids." European Journal of Pharmaceutics and Biopharmaceutics 68, no. 3 (2008): 453–66. http://dx.doi.org/10.1016/j.ejpb.2007.08.007.

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6

Freeman, Lisa, Martin Hewison, Susan V. Hughes та ін. "Expression of 11β-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells". Blood 106, № 6 (2005): 2042–49. http://dx.doi.org/10.1182/blood-2005-01-0186.

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Abstract Glucocorticoids (GCs) exert powerful anti-inflammatory effects that may relate in part to their ability to restrict the differentiation and function of dendritic cells (DCs). Although these inhibitory effects are dependent upon GCs binding to nuclear glucocorticoid receptors (GRs), fine-tuning of GR signaling is achieved by prereceptor interconversion of cortisol that binds GRs with high affinity and cortisone that does not. We show for the first time that human monocyte-derived DCs are able to generate cortisol as a consequence of up-regulated expression of the enzyme 11β-hydroxyster

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7

Cattaneo, Dario, Norberto Perico, Flavio Gaspari, Eliana Gotti, and Giuseppe Remuzzi. "Glucocorticoids interfere with mycophenolate mofetil bioavailability in kidney transplantation." Kidney International 62, no. 3 (2002): 1060–67. http://dx.doi.org/10.1046/j.1523-1755.2002.00531.x.

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8

Hu, Aihua, Sumbul Fatma, Jing Cao та ін. "Th2 cytokine-induced upregulation of 11β-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function". American Journal of Physiology-Lung Cellular and Molecular Physiology 296, № 5 (2009): L790—L803. http://dx.doi.org/10.1152/ajplung.90572.2008.

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Анотація:

The anti-inflammatory actions of endogenous glucocorticoids (GCs) are regulated by the activities of the GC-activating and -inactivating enzymes, 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 and 11β-HSD2, respectively, that catalyze the interconversion of the inert GC, cortisone, and its bioactive derivative, cortisol. Proinflammatory cytokines regulate 11β-HSD1 expression in various cell types and thereby modulate the bioavailability of cortisol to the glucocorticoid receptor (GR). Since endogenous GCs reportedly attenuate the airway asthmatic response to allergen exposure, we investigated wh

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9

Kamada, Alan K., Matthew B. Wiener, Nicole M. LaVallee, Maryanne Bartoszek Scott, John C. Seiner, and Stanley J. Szefler. "A Pharmacokinetic Comparison of Two Oral Liquid Glucocorticoid Formulations." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 17, no. 2 (1997): 353–56. http://dx.doi.org/10.1002/j.1875-9114.1997.tb03719.x.

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To compare pharmacokinetics of liquid prednisolone and prednisone solutions and to assess relative bioavailability, six healthy adult men were administered 15 mg of each formulation. Blood samples were obtained and assayed for plasma prednisolone concentrations by high‐performance liquid chromatography. Peak concentration was significantly higher with liquid prednisolone (mean ± SD 430.3 ± 62.5 vs 333.0 ± 27.8 ng/ml, p=0.013), with similar times to peak concentration. Prednisolone liquid gave higher concentrations at every time point (statistically significant for all except 0.25 hrs after the

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10

Elder, Charlotte J., Ruben Vilela, Trevor N. Johnson, et al. "Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test." Journal of Clinical Endocrinology & Metabolism 105, no. 8 (2020): 2692–703. http://dx.doi.org/10.1210/clinem/dgaa323.

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Abstract Context The Short Synacthen Test (SST) is the gold standard for diagnosing adrenal insufficiency. It requires invasive administration of Synacthen, venous sampling, and is resource-intensive. Objective To develop a nasally administered SST, with salivary glucocorticoids measurement, to assess the adrenal response. Design We conducted 5 studies: 4 open-label, sequence-randomized, crossover, pharmacodynamic studies testing 6 doses/formulations and a repeatability study. Additionally, pharmacokinetic analysis was undertaken using our chosen formulation, 500 µg tetracosactide with mucoadh

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