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Статті в журналах з теми "Guinea pig. Trachea"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Paramita, Swandari, Emil Bachtiar Moerad, Sjarif Ismail, and Eva Marliana. "Antiasthmatic effect of Curcuma aeruginosa extract on isolated organ of the trachea." F1000Research 7 (November 15, 2018): 1799. http://dx.doi.org/10.12688/f1000research.16416.1.

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Анотація:

Background:Asthma is a major health problem worldwide. Antiasthma drugs have side effects and can be expensive. It is important to develop antiasthma drugs from medicinal plants that have fewer side effects and are cheaper. One of the medicinal plants used for antiasthma treatment comes fromCurcuma aeruginosa(Zingiberaceaefamily). The aim of the research is to examine spasmolytic activity of ethanol extract ofC. aeruginosaon isolated guinea pig tracheas to determine the antiasthma effects.Methods:The spasmolytic activity ofC. aeruginosaextracts was tested in separated organs of guinea pig trac

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2

Watts, Stephanie W., Kathryn W. Schenck, and Marlene L. Cohen. "Selectlve desensitization of 5-hydroxytryptamine 2A receptor mediated contraction in guinea pig trachea." Canadian Journal of Physiology and Pharmacology 72, no. 5 (1994): 463–70. http://dx.doi.org/10.1139/y94-067.

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5-Hydroxytryptamine (serotonin, 5-HT) contracts the guinea pig trachea through stimulation of 5-HT2A receptors, an effect previously reported to rapidly desensitize. The present studies were designed to examine further the putative desensitization to serotonin. In vitro studies investigating functional desensitization of the guinea pig tracheal 5-HT2A receptor documented that 5-HT (3 × 10−7 M) significantly (50%) but incompletely reduced subsequent tracheal maximal contraction to 5-HT. In contrast, an equieffective concentration of carbamylcholine (3 × 10−8 M) did not reduce guinea pig trachea

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3

Asano, Masayuki, Hiroe Sawai, Chie Hatori, Noriaki Inamura, Tatsujiro Fujiwara, and Kunio Nakahara. "Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on guinea-pig tracheal smooth muscle bradykinin receptors." Canadian Journal of Physiology and Pharmacology 76, no. 10-11 (1998): 1051–55. http://dx.doi.org/10.1139/y98-098.

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It is speculated that bradykinin may play an important role in asthma. Thus, bradykinin receptor antagonists may have therapeutic potential against asthma. Orally active bradykinin antagonists would be more desirable for the treatment of the disease. In the present study, we examined the effects of a novel, potent, selective, and orally active nonpeptide bradykinin B2 receptor antagonist, FR167344 (N-[N-[3-[(3-bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]- 2,4-dichlorophenyl]-N-methylaminocarbonylmethyl]-4-(dimethylaminocarbonyl)cinnamylamide hydrochloride), on guinea-pig tracheal smooth

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4

Wangensteen, O. D., L. A. Schneider, S. C. Fahrenkrug, G. M. Brottman, and R. C. Maynard. "Tracheal epithelial permeability to nonelectrolytes: species differences." Journal of Applied Physiology 75, no. 2 (1993): 1009–18. http://dx.doi.org/10.1152/jappl.1993.75.2.1009.

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We developed a new excised tracheal preparation to measure the epithelial permeability of large lipid-insoluble nonelectrolytes and macromolecules. Tracheae were suspended vertically in a Ringer solution bath, and a solution containing labeled test solutes was positioned in the center of the tracheal segment, away from damaged ends. Permeability coefficients, calculated from solute fluxes into the bath, were constant for > or = 2 h at 37 degrees C, and no histological changes were observed. Measurements after epithelial removal with detergent indicate that in the intact trachea the epitheli

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5

Kizawa, Yasuo, and Issei Takayanagi. "Noncholinergic contractile response to nicotine in the guinea pig isolated tracheal smooth muscle." Canadian Journal of Physiology and Pharmacology 65, no. 2 (1987): 269–71. http://dx.doi.org/10.1139/y87-047.

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The existence of substance P immunoreactive nerves in the trachea of guinea pig is known. In this study, capsaicin induced a long-lasting and marked contraction in the guinea pig trachea and nicotine-induced contraction was partially reduced in the capsaicin-treated muscle. Furthermore, the contractile response to nicotine (10−5 M) in the presence of atropine (10−7 M) was abolished by a substance P antagonist, [D-Arg1, D-Pro2, D-Trp7,9 Leu11]substance P (10−5 M). These findings suggest that noncholinergic contractile response to nicotine may be due to the release of material(s) resembling subs

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6

Perpina, M., J. Cortijo, E. Fornas, M. Palau, JL Ortiz, and E. Morcillo. "Hyperreactivity and 45Ca movements in sensitized guinea-pig tracheal muscle." European Respiratory Journal 4, no. 4 (1991): 450–57. http://dx.doi.org/10.1183/09031936.93.04040450.

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Responses to KCl and histamine and 45Ca movements were studied in trachea from normal and actively sensitized guinea-pigs. Sensitized tracheas were hyperresponsive and hypersensitive to KCl and histamine. 45Ca uptake experiments show that sensitized tracheal muscle behaves as normal except that the uptake of 45Ca in low concentration (0.03 mM) Ca2+ solution was higher and the number of binding sites for the high affinity component of 45Ca uptake (as estimated by Scatchard-coordinate plot) was augmented. Additionally, in sensitized tracheal muscle, incubation in low (0.03 mM) Ca2+ solution foll

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7

Miyamoto, Koji, Takeshi Katsuragi, Parhat Abdu, and Tatsuo Furukawa. "Effects of Baicalein on Prostanoid Generation from the Lung and Contractile Responses of the Trachea in Guinea Pig." American Journal of Chinese Medicine 25, no. 01 (1997): 37–50. http://dx.doi.org/10.1142/s0192415x9700007x.

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Effects of baicalein on release of slow reacting substance of anaphylaxis (SRS-A) or leukotriene (L T) from the sensitized guinea pig lung after antigen challenge and tonus of guinea pig tracheal muscles were studied. Baicalein inhibited release of SRS-A from sensitized guinea pig lung after antigen challenge. High-performance liquid chromatography (HPLC) analysis revealed that released SRS-A consisted of LTC 4 and D 4. Baicalein also reduced release of LTC 4 and D 4 from the sensitized lung after antigen challenge. Baicalein relaxed the isolated guinea pig tracheal smooth muscle contracted by

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8

Rosic, Gvozden, Zorica Lazic, Suzana Pantovic, and Mirko Rosic. "Phenylethylamine effects on histamine-induced contraction of isolated guinea-pig trachea rings." Jugoslovenska medicinska biohemija 24, no. 2 (2005): 95–97. http://dx.doi.org/10.2298/jmh0502095r.

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Histamine produces constriction of tracheal smooth muscle via H1 receptors, but it also decreases tracheal smooth muscle tone via H2 and H3 receptors. In addition, it has already been reported that phenylethylamine is competitive antagonist of histamine N-methyl-transferase (HMT), enzyme responsible for rapid inactivation of histamine. Our results suggest possibility that phenylethylamine as competitive antagonist of histamine N-methyl-transferase leads to potentiation of histamine induced constriction of isolated guinea-pig trachea, which could be consequence of decreased histamine methylatio

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9

Dellabianca, Antonio, Carolina Beretta, Marisa Faniglione та ін. "A PPAR-α AGONIST PROTECTS THE NON-ADRENERGIC, NON-CHOLINERGIC INHIBITORY SYSTEM OF GUINEA PIG TRACHEA FROM THE EFFECT OF INHALED AMMONIUM PERSULPHATE: A PILOT STUDY". Giornale Italiano di Medicina del Lavoro ed Ergonomia 42, № 3 (2025): 153–59. https://doi.org/10.4081/gimle.452.

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Aim of the study. Inhaled ammonium persulphate (AP) reduces non adrenergic, non cholinergic (NANC) relaxation in the guinea pig trachea, as a part of its inflammatory effects. Peroxisome Proliferator-Activated Receptor (PPAR) stimulation has shown anti-inflammatory properties. This study aimed at evaluating whether the PPAR-α agonist WY 14643 can prevent the reduction in NANC relaxation caused by inhaled AP in the guinea pig trachea. Materials and Methods. Four groups of ten male guinea pigs were treated for three weeks with inhaled AP (10 mg/m3, 30 min per day, group A), saline (group B), AP

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10

Munakata, M., W. Mitzner, and H. Menkes. "Osmotic stimuli induce epithelial-dependent relaxation in the guinea pig trachea." Journal of Applied Physiology 64, no. 1 (1988): 466–71. http://dx.doi.org/10.1152/jappl.1988.64.1.466.

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Epithelium in airways, like endothelium in blood vessels, may regulate responses of adjacent smooth muscle. To study the intact trachea from guinea pigs we developed an in vitro preparation that permits independent stimulation from either the inner epithelial surface or the outer serosal surface. The whole guinea pig trachea was excised, cannulated, and perfused at a constant flow with Krebs-Henseleit (KH) solution that was in direct contact with the inner epithelial-lined surface. The outer serosal surface of the trachea was immersed in a separate system (bath) containing KH solution. Trachea

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11

Ginting, Nahitma, Edy Suwarso, Daud Vincen Rumapea, and Nerdy Nerdy. "RELAXATION ACTIVITY OF TETANUS (LEEA AEQUATA L.) LEAF ETHANOLIC EXTRACT ON GUINEA PIG ISOLATED TRACHEA." Asian Journal of Pharmaceutical and Clinical Research 11, no. 13 (2018): 24. http://dx.doi.org/10.22159/ajpcr.2018.v11s1.26557.

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Objective: The aim of this study is to determine the relaxation activity of the ethanolic extract of tetanus leaf (EETL) against contracting isolated guinea pig trachea induced by acetylcholine.Methods: Isolated trachea was equilibrated for 45 min until a stable condition in the Creb’s solution with a temperature of 37°C aerated with carbogen gas (O2:CO2=95%:5%). Test of the relaxation effect conducted after guinea pig trachea contracted with maximum acetylcholine concentration (EC80: 2.0449×10–3 mol) and then a cumulative with concentration of EETL (0.5 mg/mL–4 mg/mL) and concentration of atr

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12

Jones, T. R., R. Zamboni, M. Belley, et al. "Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist." Canadian Journal of Physiology and Pharmacology 67, no. 1 (1989): 17–28. http://dx.doi.org/10.1139/y89-004.

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Анотація:

L-660,711 (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl) ((3-dimethyl amino-3-oxo propyl)thio)methyl)thio)propanoic acid is a potent and selective competitive inhibitor of [3H]leukotriene D4 binding in guinea pig (Ki value, 0.22 nM) and human (Ki value, 2.1 nM) lung membranes but is essentially inactive versus [3H]leukotriene C4 binding (IC50 value in guinea pig lung, 23 μM). Functionally it competitively antagonized contractions of guinea pig trachea and ileum induced by leukotriene (LT) D4 (respective pA2 values, 9.4 and 10.5) and LTE4 (respective pA2 values, 9.1 and 10.4) and contractions

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13

Sadeghi-Hashjin, G., P. A. J. Henricks, G. Folkerts, T. Muis, J. Garssen, and F. P. Nijkamp. "Role of the epithelial layer in the generation of superoxide anion by the guinea-pig isolated trachea." Mediators of Inflammation 7, no. 1 (1998): 35–40. http://dx.doi.org/10.1080/09629359891360.

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The lucigenin-dependent chemiluminescence generation by guinea-pig isolated tracheal two rings preparations was studied. Tracheal preparations stimulated with phorbol myristate acetate (PMA) or opsonized zymosan generated chemiluminescence. The total amount of chemiluminescence generated in 120 min was 754 ± 63 mV × min for PMA and 4832 ±396 mV × min for zymosan. Generation of chemiluminescence was decreased by more than 50% when the tissues were co-incubated with superoxide dismutase (100 U/ml). Also, addition of direct donors of nitric oxide diminished chemiluminescence generation by zymosan

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14

Jones, T. R., Y. Guindon, R. Young та ін. "L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylsulfonyl]-γ-oxo-benzenebutanoate: a leukotriene D4 receptor antagonist". Canadian Journal of Physiology and Pharmacology 64, № 12 (1986): 1535–42. http://dx.doi.org/10.1139/y86-258.

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L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylsulfonyl]-γ-oxo-benzenebutanoate is a selective and competitive inhibitor of [3H]leukotriene D4 (KB value of 4.0 μM) and to a lesser extent [3H]leukotriene C4 (Ki value of 36.7 μM) binding in guinea pig lung homogenates. Functionally, it selectively antagonized contractions of guinea pig trachea induced by leukotrienes C4, D4, E4, and F4 in concentrations that did not antagonize contractions induced by acetylcholine, histamine, serotonin, prostaglandin F2α, or U-44069 (endoperoxide analogue). Schild plot analysis indicated that L

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15

Yagi, Yukihiro, Masayoshi Kuwahara, and Hirokazu Tsubone. "ChTX induces oscillatory contraction in guinea pig trachea: role of cyclooxygenase-2 and PGE2." American Journal of Physiology-Lung Cellular and Molecular Physiology 284, no. 6 (2003): L1045—L1054. http://dx.doi.org/10.1152/ajplung.00054.2002.

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We examined the possible role of cyclooxygenase (COX) in charybdotoxin (ChTX)-induced oscillatory contraction in guinea pig trachea. Involvement of prostaglandin E2 (PGE2) in ChTX-induced oscillatory contraction was also investigated. ChTX (100 nM) induced oscillatory contraction in guinea pig trachea. The mean oscillatory frequency induced by ChTX was 10.7 ± 0.8 counts/h. Maximum and minimum tensions within ChTX-induced oscillatory contractions were 68.4 ± 1.8 and 14.3 ± 1.7% compared with K+ (72.7 mM) contractions. ChTX-induced oscillatory contraction was completely inhibited by indomethacin

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16

Jones, T. R., R. Young, E. Champion та ін. "L-649,923, Sodium (βS*, γR*)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylthio)-γ-hydroxy-β-methylbenzenebutanoate, a selective, orally active leukotriene receptor antagonist". Canadian Journal of Physiology and Pharmacology 64, № 8 (1986): 1068–75. http://dx.doi.org/10.1139/y86-183.

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L-649,923, Sodium (βs*, γR*)-4-(3-(4-acetyi-3-hydroxy-2-propylphenoxy)propylthio)-γ-hydroxy-β-methylbenzenebutanoate is a selective and competitive inhibitor of [3H]leukotriene D4 (Ki value of 400 nM) and to a lesser extent [3H]leukotriene C4 (Ki value of 8.6 μM) binding in guinea-pig lung homogenates. Functionally, it selectively antagonized contractions of guinea pig trachea induced by leukotriene C4, D4, E4, and F4 but not those induced by acetylcholine, histamine, serotonin, prostaglandin F2α, or U-44069 (stable endoperoxide analogue). Schild plot analysis indicated a competitive inhibitio

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17

Mazzone, Stuart B., and Alice E. McGovern. "Innervation of tracheal parasympathetic ganglia by esophageal cholinergic neurons: evidence from anatomic and functional studies in guinea pigs." American Journal of Physiology-Lung Cellular and Molecular Physiology 298, no. 3 (2010): L404—L416. http://dx.doi.org/10.1152/ajplung.00166.2009.

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In the present study, we describe a subset of nerve fibers, characterized by their immunoreactivity for the calcium-binding protein calretinin, that are densely and selectively associated with cholinergic postganglionic neurons in the guinea pig tracheal ganglia. Retrograde neuronal tracing with cholera toxin B, combined with immunohistochemical analyses, showed that these nerve fibers do not originate from sensory neurons in the nodose, jugular, or dorsal root ganglia or from motor neurons in the nucleus ambiguus, dorsal motor nucleus of the vagus nerve, spinal cord, stellate ganglia, or supe

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18

Charette, L., C. Misquitta, J. Guay, D. Riendeau, and T. R. Jones. "Involvement of cyclooxygenase 2 (COX-2) in intrinsic tone of isolated guinea pig." Canadian Journal of Physiology and Pharmacology 73, no. 11 (1995): 1561–67. http://dx.doi.org/10.1139/y95-215.

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Indomethacin and related nonsteroidal anti-inflammatory drugs relax prostanoid-dependent intrinsic tone of isolated guinea pig trachea by inhibiting cyclooxygenase (COX). Recently, a second isoform of COX (COX-2) was discovered, which differed from COX-1 with respect to protein structure, transcriptional regulation, and susceptibility to inhibition by pharmacological agents. It is now known that indomethacin nonselectively inhibits COX-1 and COX-2, whereas NS-398 is a selective inhibitor of COX-2. In the present study we compared the activity of a selective (NS-398) and nonselective (indometha

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19

Popko, Svitlana, and Mariya Aksamytieva. "The possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in guinea pigs." EUREKA: Health Sciences, no. 2 (March 31, 2022): 17–22. https://doi.org/10.21303/2504-5679.2022.002272.

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Анотація:

The present study was aimed to evaluate the possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in the guinea pigs' trachea and lung in early and late manifestations of the allergic inflammatory process. Materials and methods.We have studied the distribution and quantitative changes of CD3-positive lymphocytes in trachea and lung of guinea pigs using histological, immunohistochemical, statistical methods in conditions of experimental inflammatory process. Results. Our results revealed the applicability of anti-Human monoclonal antibody CD3 (Clone SP7, «DAKO», Denmark)

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20

Haddad, E. B., Y. Landry, and J. P. Gies. "Muscarinic receptor subtypes in guinea pig airways." American Journal of Physiology-Lung Cellular and Molecular Physiology 261, no. 4 (1991): L327—L333. http://dx.doi.org/10.1152/ajplung.1991.261.4.l327.

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The muscarinic receptors present in the guinea pig tracheobronchial tree were characterized using ligand-binding studies and functional approaches. The binding constants of four selective antagonists, pirenzepine,[11-([2-[(diethylamino) methyl]-1-piperidinyl]acetyl)-5,11-dihydro-6H-pyrido(2,3) (1,4) benzodiazepine-6-on] (AF-DX 116), methoctramine, and 4-diphenylacetoxy-Nmethylpiperidine methobromide(4-DAMP) were examined. Heterogeneity in the airway muscarinic receptors population was revealed by competitive binding experiments against [N-methyl3H]scopolamine with the M2 muscarinic antagonists

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21

Kloek, Joris, Ingrid van Ark, Nanne Bloksma, Fred De Clerck, Frans P. Nijkamp, and Gert Folkerts. "Glutathione and other low-molecular-weight thiols relax guinea pig trachea ex vivo: interactions with nitric oxide?" American Journal of Physiology-Lung Cellular and Molecular Physiology 283, no. 2 (2002): L403—L408. http://dx.doi.org/10.1152/ajplung.00376.2001.

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The aim of this study was to determine the effects of glutathione (GSH) on trachea smooth muscle tension in view of previously reported interactions between GSH and nitric oxide (NO) (Gaston B. Biochim Biophys Acta 1411: 323–333, 1999; Kelm M. Biochim Biophys Acta 1411: 273–289, 1999; and Kharitonov VG, Sundquist AR, and Sharma VS. J Biol Chem 270: 28158–28164, 1995) and the high (millimolar) concentrations of GSH in trachea epithelium (Rahman I, Li XY, Donaldson K, Harrison DJ, and MacNee W. Am J Physiol Lung Cell Mol Physiol 269: L285–L292, 1995). GSH and other thiols (1.0–10 mM) dose depend

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22

Potvin, W., and D. R. Varma. "Bronchodilator activity of atrial natriuretic peptide in guinea pigs." Canadian Journal of Physiology and Pharmacology 67, no. 10 (1989): 1213–18. http://dx.doi.org/10.1139/y89-192.

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Анотація:

Atrial natriuretic peptide (ANP) produced concentration-dependent relaxation of isolated guinea pig tracheal chains contracted with histamine, serotonin, carbachol, and arachidonic acid. ANP was a full agonist. ANP was two-to three-fold less potent when compared with isoprenaline in relaxing histamine-, serotonin-, and arachidonic acid-contracted tracheal chains. However, ANP was 20-fold less potent than isoprenaline in relaxing carbachol-contracted tracheal chains. The relaxant potencies of isoprenaline and sodium nitroprusside were similar regardless of the agent used to induce the tone. ANP

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23

Yang, Z.-J., and D. F. Biggs. "Muscarinic-receptor functioning in tracheas from normal and ovalbumin-sensitive guinea pigs." Canadian Journal of Physiology and Pharmacology 69, no. 6 (1991): 871–76. http://dx.doi.org/10.1139/y91-132.

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Анотація:

Responses to bilateral vagal nerve stimulation, to field stimulation, and to exogenous methacholine and histamine were compared in tracheas isolated from (a) saline injected (i.p.) and saline-aerosol exposed guinea pigs (control), (b) ovalbumin-sensitized and saline-aerosol exposed (sensitized) guinea pigs, and (c) ovalbumin-sensitized and 2% ovalbumin-aerosol exposed (challenged) guinea pigs. Tracheal pressor responses (cmH2O; 1 cmH2O = 98.1 Pa) to nerve and field stimulation, and maximal responses to methacholine and histamine were significantly increased in animals from group c compared wit

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24

Ben-Harari, R. R., B. A. Dalton, and U. C. Garg. "Modulation of rate at which serotonin-induced contraction decays in guinea pig trachea." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 1 (1994): R221—R227. http://dx.doi.org/10.1152/ajpregu.1994.266.1.r221.

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Анотація:

Stimulation of the type 2 serotonin (5-HT2) receptor in guinea pig trachea with 5-HT results in a contraction that decays in the continued presence of 5-HT. The decay of the 5-HT contraction has been proposed to be dependent on 5-HT2 receptor activation and to reflect desensitization of the receptor. The characteristics of the decay of the 5-HT contraction may also be dependent on other properties of the tissue. The effects of modulation of biochemical pathways implicated in airway smooth muscle contraction on the 5-HT contraction in isolated guinea pig trachea were determined with the use of

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25

Yamaguchi, T., H. Kohrogi, O. Kawano, M. Ando, and S. Araki. "Neutral endopeptidase inhibitor potentiates endothelin-1-induced airway smooth muscle contraction." Journal of Applied Physiology 73, no. 3 (1992): 1108–13. http://dx.doi.org/10.1152/jappl.1992.73.3.1108.

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Анотація:

To study the role of neutral endopeptidase (NEP) on endothelin-1-induced contraction of the airway smooth muscle, we examined the contractile effect of endothelin-1 in the isolated guinea pig trachea and human bronchus in the presence or absence of NEP inhibitor phosphoramidon. After incubation with phosphoramidon (10(-8) to 10(-5) M), we added endothelin-1 cumulatively from 10(-11) to 10(-7) M to the airway tissues in organ baths. Phosphoramidon significantly potentiated the endothelin-1-induced contraction in a concentration-dependent fashion in both guinea pig trachea and human bronchus, an

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26

Pedersen, Karen E., Sonya N. Meeker, Margerita M. Riccio, and Bradley J. Undem. "Selective stimulation of jugular ganglion afferent neurons in guinea pig airways by hypertonic saline." Journal of Applied Physiology 84, no. 2 (1998): 499–506. http://dx.doi.org/10.1152/jappl.1998.84.2.499.

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Анотація:

Pedersen, Karen E., Sonya N. Meeker, Margerita M. Riccio, and Bradley J. Undem. Selective stimulation of jugular ganglion afferent neurons in guinea pig airways by hypertonic saline. J. Appl. Physiol. 84(2): 499–506, 1998.—We evaluated the ability of hyperosmolar stimuli to activate afferent nerves in the guinea pig trachea and main bronchi and investigated the neural pathways involved. By using electrophysiological techniques, studies in vitro examined the effect of hyperosmolar solutions of sodium chloride (hypertonic saline) on guinea pig airway afferent nerve endings arising from either va

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27

Xu, Xianghuai, Qiang Chen, Zhongmin Qiu, et al. "Association of cough hypersensitivity with tracheal TRPV1 activation and neurogenic inflammation in a novel guinea pig model of citric acid-induced chronic cough." Journal of International Medical Research 46, no. 7 (2018): 2913–24. http://dx.doi.org/10.1177/0300060518778951.

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Objective This study was performed to establish a novel model of citric acid-induced chronic cough in guinea pigs and to investigate the pathogenesis of cough hypersensitivity. Methods Healthy conscious guinea pigs inhaled citric acid (0.4 M) for 3 minutes twice daily for 25 days. Cough reactivity was evaluated, substance P (SP) and calcitonin gene-related peptide (CGRP) in bronchoalveolar lavage fluid were detected, and transient receptor potential cation channel subfamily V member 1 (TRPV1) protein expression in the trachea and bronchus was determined. Tracheal and bronchial tissues were exa

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Takayanagi, Issei, Mitsutoshi Satoh, Noriko Kokubu та Teruko Kato. "Relationship between potency of L-isoprenaline and β-adrenoceptor density estimated in single cells from tracheal smooth muscles of guinea pigs of different ages". Canadian Journal of Physiology and Pharmacology 70, № 4 (1992): 458–61. http://dx.doi.org/10.1139/y92-059.

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An age-related change in potency of L-isoprenaline in the presence of ascorbic acid, desmethylimipramine, corticosterone, pargyline, and phentolamine was obtained in tracheal strips from guinea pigs of differing ages between 6 and 40 weeks. The potency in the strips from 100-week-old guinea pigs did not significantly differ from that in strips from 40-week-old animals. Single cells were prepared from the tracheal muscles of 6-, 10-, 40-, and 100-week-old guinea pigs. The specific binding of [3H]dihydroalprenolol to the single cells was saturable. The dissociation constants of [3H]dihydroalpren

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29

Braden, N. J., and P. D. Walson. "1731 XANTHINE ACTIONS IN GUINEA PIG TRACHEA." Pediatric Research 19, no. 4 (1985): 399A. http://dx.doi.org/10.1203/00006450-198504000-01749.

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30

Takayanagi, Issei, Ken-ichi Kawano та Katsuo Koike. "α2-adrenoceptor mechanisms in guinea-pig trachea". European Journal of Pharmacology 182, № 3 (1990): 577–80. http://dx.doi.org/10.1016/0014-2999(90)90059-f.

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31

Christ, Michael J., Lynn M. Iwamoto, Asoka de Silva, Sarah L. Lavallee, and Kenneth T. Nakamura. "Amiloride-induced contraction of isolated guinea pig, mouse, and human fetal airways." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274, no. 1 (1998): R209—R213. http://dx.doi.org/10.1152/ajpregu.1998.274.1.r209.

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Nebulized amiloride has been proposed as therapy in cystic fibrosis to block Na+ hyperabsorption in airway epithelium and prevent dehydration of secretions. Patients with cystic fibrosis often have reactive airways. Bovine and canine trachea relax to amiloride in vitro, suggesting another benefit as a bronchodilator, whereas guinea pig trachea, a useful model of human airways, does not. We hypothesized that human airways would respond like guinea pig airways. Airway ring segments from guinea pigs, mice, and human fetuses were constricted with the concentration of acetylcholine producing 50–75%

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32

Takubo, T., K. Banks, and J. G. Martin. "Epithelium modulates the potency of vasoactive intestinal peptide in the guinea pig." Journal of Applied Physiology 71, no. 6 (1991): 2146–51. http://dx.doi.org/10.1152/jappl.1991.71.6.2146.

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The purpose of the study was to evaluate the importance of the epithelium in determining the potency of exogenous vasoactive intestinal peptide (VIP) in inhibiting responses of isolated guinea pig trachea to vagal stimulation. Isolated innervated tracheal preparations (n = 56) were mounted in glass organ baths in Krebs-Henseleit (K-H) solution at 37 degrees C and gassed with 95% O2–5% CO2. The inside of the trachea was separately perfused with K-H solution at 1 ml/min. The vagal nerve trunks were stimulated (20 V, 1-ms pulses, 10-s trains) at low (0.5 Hz) and high frequency (15 Hz) alternately

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33

Baker, D. G., H. F. Don, and J. K. Brown. "Direct measurement of acetylcholine release in guinea pig trachea." American Journal of Physiology-Lung Cellular and Molecular Physiology 263, no. 1 (1992): L142—L147. http://dx.doi.org/10.1152/ajplung.1992.263.1.l142.

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In this study, we applied high-performance liquid chromatography with electrochemical detection (HPLC-EC) to the measurement of acetylcholine (ACh) release from nerve endings in guinea pig tracheal smooth muscle. We also tested for muscarinic inhibitory regulation of ACh release in this species, which is widely used for studies of airway neural control. Clip-connected segments of the posterior membrane of the guinea pig trachea were mounted in organ baths between stimulating electrodes and incubated in Krebs-Henseleit buffer containing (in microM) 10 indomethacin, 1 neostigmine, 1 phentolamine

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34

Yuebin, Zheng, Florenly, Liena, and Fioni. "Effects of Curcuma Longa Ethanol Extract on Isolated Guinea Pigthile Smooth Muscle in Acetylcholine Induction." Britain International of Exact Sciences (BIoEx) Journal 4, no. 1 (2021): 13–23. http://dx.doi.org/10.33258/bioex.v4i1.540.

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Epidemiological studies show that nearly 20% of the world's population suffers from diseases related to allergies and asthma. The main compound of turmeric is curcumin has several pharmacological properties, antioxidant properties, anti-inflammatory, asthma treatment. The study aimed to determine the effects of ethanol extract Curcuma longa on the smooth muscle of the isolated guinea pigtic trachea in acetylcholine induction. This research method was experimental to observe the relationship of Curcuma longa ethanol extract (EECL) to the relaxing effects of isolated smooth muscle trachea marmot

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35

Minette, P. A., and P. J. Barnes. "Prejunctional inhibitory muscarinic receptors on cholinergic nerves in human and guinea pig airways." Journal of Applied Physiology 64, no. 6 (1988): 2532–37. http://dx.doi.org/10.1152/jappl.1988.64.6.2532.

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We have investigated whether prejunctional inhibitory muscarinic receptors ("autoreceptors") exist on cholinergic nerves in human airways in vitro and whether guinea pig trachea provides a good model for further pharmacological characterization of these receptors. Pilocarpine was used as a selective agonist and gallamine as a selective antagonist of these autoreceptors. Acetylcholine (ACh) release from postganglionic cholinergic nerves was elicited by electrical field stimulation (EFS) (40 V, 0.5 ms, 32 Hz). In human bronchi, pilocarpine inhibited the contractile response to EFS in a dose-rela

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36

Munakata, M., I. Huang, W. Mitzner, and H. Menkes. "Protective role of epithelium in the guinea pig airway." Journal of Applied Physiology 66, no. 4 (1989): 1547–52. http://dx.doi.org/10.1152/jappl.1989.66.4.1547.

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We developed an in vitro system to assess the role of the epithelium in regulating airway tone using the intact guinea pig trachea (J. Appl. Physiol. 64: 466–471, 1988). This method allows us to study the response of the airway when its inner epithelial surface or its outer serosal surface is stimulated independently. Using this system we evaluated how the presence of intact epithelium can affect pharmacological responsiveness. We first examined responses of tracheae with intact epithelium to histamine, acetylcholine, and hypertonic KCl when stimulated from the epithelial or serosal side. We t

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37

Lenon, George Binh, Chun Guang Li, Charlie Changli Xue, Francis Chung Kong Thien, and David Frederick Story. "Inhibition of Release of Vasoactive and Inflammatory Mediators in Airway and Vascular Tissues and Macrophages by a Chinese Herbal Medicine Formula for Allergic Rhinitis." Evidence-Based Complementary and Alternative Medicine 4, no. 2 (2007): 209–17. http://dx.doi.org/10.1093/ecam/nel083.

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Herbal therapies are being used increasingly for the treatment of allergic rhinitis. The aim of this study was to investigate the possible pharmacological actions and cellular targets of a Chinese herbal formula (RCM-101), which was previously shown to be effective in reducing seasonal allergic rhinitis symptoms in a randomized, placebo-controlled clinical trial. Rat and guinea pig isolated tissues (trachea and aorta) were used to study the effects of RCM-101 on responses to various mediators. Production of leukotriene B4in porcine neutrophils and of prostaglandin E2and nitric oxide (NO) in Ra

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38

Gurjar, Vinod Kumar, and Dilipkumar Pal. "Design, in silico studies, and synthesis of new 1,8-naphthyridine-3-carboxylic acid analogues and evaluation of their H1R antagonism effects." RSC Advances 10, no. 23 (2020): 13907–21. http://dx.doi.org/10.1039/d0ra00746c.

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New 1,8-naphthyridine-3-carboxylic acid derivatives were designed, synthesized and evaluated for their in vivo antihistaminic activity on guinea pig trachea by using chlorpheniramine maleate as the standard drug.

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39

Venugopalan, C. S., E. P. Holmes, V. Fucci, and A. J. Guthrie. "Stimulation frequency-dependent nonadrenergic noncholinergic airway responses of the guinea pig." Journal of Applied Physiology 70, no. 3 (1991): 1006–10. http://dx.doi.org/10.1152/jappl.1991.70.3.1006.

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We examined the inhibitory and excitatory components of the nonadrenergic noncholinergic (NANC) innervation of the guinea pig airways by in vivo and in vitro methods. Electrical stimulation of the vagus in chloralose-urethan-anesthetized guinea pigs after cholinergic and adrenergic blockade produced peripheral airway constriction (insufflation pressure) and tracheal relaxation (pouch pressure). Vagal stimulation was applied for 90 s at 5-V pulses of 2-ms duration at frequencies of 5, 15, 25, and 35 Hz in each group (n = 6). The pouch relaxation peaked at 15 Hz. The insufflation pressure was hi

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40

Bertrand, C., P. Geppetti, J. Baker, I. Yamawaki, and J. A. Nadel. "Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea." Journal of Immunology 150, no. 4 (1993): 1479–85. http://dx.doi.org/10.4049/jimmunol.150.4.1479.

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Abstract Conflicting results have been reported about the role of sensory nerves in the allergen-induced plasma extravasation in sensitized guinea pigs using capsaicin desensitization. To investigate the role of tachykinins released from sensory nerves in the anaphylactic reaction in guinea pigs in vivo, we used a selective inhibitor of neutral endopeptidase, phosphoramidon, and a selective neurokinin (NK)-1 receptor antagonist, CP-96,345. Male Hartley guinea pigs were sensitized to OVA by two i.p. injections (70 mg) at 1-wk intervals. Two wk later, the animals were anesthetized and OVA was ad

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41

Bramich, Narelle J. "Electrical behavior of guinea pig tracheal smooth muscle." American Journal of Physiology-Lung Cellular and Molecular Physiology 278, no. 2 (2000): L320—L328. http://dx.doi.org/10.1152/ajplung.2000.278.2.l320.

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Intracellular recordings were taken from the smooth muscle of the guinea pig trachea, and the effects of intrinsic nerve stimulation were examined. Approximately 50% of the cells had stable resting membrane potentials of −50 ± 1 mV. The remaining cells displayed spontaneous oscillations in membrane potential, which were abolished either by blocking voltage-dependent Ca2+channels with nifedipine or by depleting intracellular Ca2+stores with ryanodine. In quiescent cells, stimulation with a single impulse evoked an excitatory junction potential (EJP). In 30% of these cells, trains of stimuli evo

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42

Fernandes, Lynette B., Darryl A. Knight, Paul J. Rigby, Domenico Spina, James W. Paterson та Roy G. Goldie. "β-Adrenoceptor desensitization in guinea-pig isolated trachea". European Journal of Pharmacology 157, № 2-3 (1988): 135–45. http://dx.doi.org/10.1016/0014-2999(88)90376-7.

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43

Rhaleb, Nour-Eddine, Noureddine Rouissi, Guy Drapeau, Daniela Jukic, and Domenico Regoli. "Characterization of bradykinin receptors in peripheral organs." Canadian Journal of Physiology and Pharmacology 69, no. 7 (1991): 938–43. http://dx.doi.org/10.1139/y91-142.

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Bradykinin (BK) and related kinins are potent stimulants of the rabbit jugular vein, the hamster urinary bladder, and the guinea pig trachea. The characterization of kinin receptors in these tissues was made with agonists and antagonists. Results obtained with agonists indicate that bradykinin and kallidin are much more active than des-Arg9-BK and suggest the presence of B2 receptors in the three organs. Some new agonists were also tested and the BK analogue, [Hyp3,Tyr(Me)8]BK, was found to be a potent and selective stimulant of the three preparations, with pD2 values of 8.56, 8.00, and 8.39,

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44

Arp, Lawrence H., Randy D. Leyh, and Ronald W. Griffith. "Adherence of Bordetella avium to tracheal mucosa of turkeys: Correlation with hemagglutination." American Journal of Veterinary Research 49, no. 5 (1988): 693–96. https://doi.org/10.2460/ajvr.1988.49.05.693.

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SUMMARY Adherence to turkey tracheal mucosa and agglutination of guinea pig erythrocytes were determined for 20 strains of Bordetella avium. Ten type-I strains, 7 type-II strains, 2 transposon-induced mutants, and 1 revertant were evaluated. All type-I strains adhered readily to tracheal mucosa and agglutinated erythrocytes, whereas no type-II strains adhered to trachea or caused hemagglutination (ha). Two mutants selected for loss of ha activity were less adherent to tracheal mucosa, compared with the parent strain. Reversion of one mutant to ha-positive status was accompanied by reconstituti

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45

Tousignant, Christine, Chi-Chung Chan, Donna Young, Diane Guevremont, and Ian W. Rodger. "Neurokinin receptor mediated plasma extravasation in guinea pig and rat airways: comparison of 125I-labelled human fibrinogen and 99mTc-labelIed human serum albumin as markers of leakage." Canadian Journal of Physiology and Pharmacology 71, no. 7 (1993): 506–11. http://dx.doi.org/10.1139/y93-073.

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In the present study we have characterized NK-1 and NK-2 receptor induced microvascular leakage in guinea pig and rat airways, using 125I-labelled human fibrinogen ([125I]FN) versus 99mTc-labelled human serum albumin ([99mTc]HSA) as markers for plasma protein extravasation. Intravenous administration of the selective NK-1 agonist [Sar9, Met(O2)11]SP (1 nmol kg−1) caused a dose-dependent increase of [125I]FN extravasation in guinea pig trachea, main bronchi, secondary bronchi, and intraparenchymal airways. Extravasation of [125I]FN increased by up to 192 (trachea), 284 (main bronchi), 368 (seco

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46

Baker, D. G., H. F. Don, and J. K. Brown. "N-type, omega-conotoxin-sensitive Ca2+ channels mediate electrically evoked release of ACh in guinea pig trachea." American Journal of Physiology-Lung Cellular and Molecular Physiology 264, no. 6 (1993): L581—L586. http://dx.doi.org/10.1152/ajplung.1993.264.6.l581.

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To determine whether N- or L-type Ca2+ channels mediate acetylcholine (ACh) release from airway parasympathetic nerve endings, we compared the effects of omega-conotoxin (N-type inhibitor) and nifedipine (L-type inhibitor) on electrically evoked release of ACh in guinea pig trachea. Reconnected segments of guinea pig trachea were mounted in organ baths containing Krebs-Henseleit buffer, indomethacin (10 microM) to inhibit cyclooxygenase, neostigmine (1 microM) to inhibit acetylcholinesterase, and atropine (0.3 microM) to inhibit muscarinic autoreceptors, as well as phentolamine and propranolol

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47

Andriantsalama Mario REBOZA, Jeanne Mérédith RAOLIARISOA, Delore Soaviherimbola RAZAFIMAHAZORO, Nathaniel QUANSAH, Jean François RAJAONARISON, and Patricia RANDRIANAVONY. "Anti-asthmatic activity of hydro alcoholic extract of Buddleja madagascariensis (Lam.) leaves in Guinea pig." GSC Biological and Pharmaceutical Sciences 30, no. 1 (2025): 046–50. https://doi.org/10.30574/gscbps.2025.30.1.0500.

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The anti-asthmatic activity of the hydro alcoholic extract of Buddleja madagascariensis (Lam.) leaves was evaluated in vivo in guinea pigs and in vitro using the isolated guinea pig trachea. Administered orally at doses 50, 100, 200 and 400 mg/kg it protects animals from spasm of the air way caused by histamine aerosol 0.5 % pulverization. Dyspnoea starts at 68 ± 1.20 sec for control group animals, versus 120.25 ± 1.03, 156 ± 2.04, 240 ± 2.07 and 279 ± 1.68 sec for the animals treated with the extract at doses 50, 100, 200 and 400 mg/kg respectively (p<0.05). In vitro, the hydro alcoholic e

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48

Tamaoki, J., K. Takeyama, I. Yamawaki, M. Kondo, and K. Konno. "Lipopolysaccharide-induced goblet cell hypersecretion in the guinea pig trachea: inhibition by macrolides." American Journal of Physiology-Lung Cellular and Molecular Physiology 272, no. 1 (1997): L15—L19. http://dx.doi.org/10.1152/ajplung.1997.272.1.l15.

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We studied the effects of macrolides on lipopolysaccharide (LPS)-induced airway goblet cell secretion in the guinea pig trachea. The goblet cell secretion was assessed in histological sections of the tracheal mucosa stained with alcian blue and periodic acid Schiff by arbitrarily determining mucus score, which is inversely related to the magnitude of mucus discharge. Inhalation of Escherichia coli LPS (5 mg/kg) caused a time-dependent decrease in mucus score, with the maximal response being from 542 +/- 49 to 92 +/- 20 arbitrary units (P < 0.001) after 3 h, which was accompanied by an incre

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Boskabady, Mohammad Hossein, Mahsa Kaveh, Naeima Eftekhar та Ali Nemati. "Zataria multiflora Boissand Carvacrol Affect β2-Adrenoceptors of Guinea Pig Trachea". Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/857124.

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The stimulatory effect ofZataria multiflora Boiss(Labiatae) and carvacrol on β-adrenoceptors was examined on guinea pig trachea. The effects of three concentrations of aqueous-ethanolic extract, carvacrol, and propranolol (β-receptor antagonist) on β-adrenoceptors were tested in nonincubated (group 1,n=8) and incubated tracheal chains with 1 μM chlorpheniramine (histamine H1 receptor antagonist) (group 2,n=5). Isoprenaline (β-receptor agonist) curves obtained in the presence of all concentrations of the extract and carvacrol showed leftward shifts compared with that of saline in both groups. I

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Lenox, W. Casey, Wayne Mitzner, and Carol A. Hirshman. "Mechanism of Thiopental-Induced Constriction of Guinea Pig Trachea." Anesthesiology 72, no. 5 (1990): 921–25. http://dx.doi.org/10.1097/00000542-199005000-00023.

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