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Дисертації з теми "(H1N1) 2009 virus"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Smith, Tammie. "The 2009 H1N1 influenza A “swine flu” virus presentation in Virginia 2009." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1990.

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Objective: 2009 H1N1 influenza was first detected in the Northern Hemisphere in April 2009. National data have suggested that the novel influenza virus disproportionately causes severe illness in children and young adults, a somewhat different presentation from traditional seasonal flu which normally strikes hardest in the very young and older adults. This may or may not be the case in Virginia, which, if it is different, may suggest a need to alter flu prevention messages and vaccine policy as the outbreak continues through the fall 2009-10 influenza season. This report examined the early pr

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2

Hedge, Jessica. "Molecular epidemiology and evolution of the 2009 H1N1 influenza A pandemic virus." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/15901.

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The swine-origin H1N1 influenza A pandemic virus (A(H1N1)pdm09) was detected in the human population in March 2009. Due to its antigenic novelty, the majority of individuals were susceptible to the virus and the pandemic quickly disseminated around the globe. Rapid characterization of the epidemic was required in order to help inform interventions and determine the risk posed to public health. Widespread sampling and sequencing of virus isolates enabled early characterization of the virus using phylogenetic analysis and continued surveillance over the subsequent three years of global circulati

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3

Mahallawi, Waleed. "Natural immunity to influenza virus in humans following 2009 pandemic H1N1 influenza." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/13137/.

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Influenza is a highly contagious and acute respiratory infection caused by influenza virus in the mucosa of the respiratory tract. Both seasonal and pandemic influenza continue to cause substantial morbidity and mortality in humans. The 2009 pandemic H1N1 (pH1N1) influenza and the potential of a highly pathogenic avian H5N1 (aH5N1) pandemic highlighted the need for effective preventative strategies. Understanding the development of natural immunity following the pH1N1 pandemic may provide important information on host protective immunity in humans, which could inform future more effective vacc

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4

Lau, Siu-ying, and 劉韶瑩. "Characterizations of antigenic and receptor binding properties of avian H5N1 and 2009 pandemic H1N1 viruses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47165078.

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Avian H5N1 viruses have perpetuated in poultry and caused sporadic human transmission since 1997. Vaccine candidates for the potential pandemic caused by H5N1 viruses have been continuously updated by World Health Organization. Multiple genetic lineages of H5N1 viruses which co-circulate and rapidly evolve in different regions, together with periodic population replacement of newly emerged genetic and antigenic variants in the field, pose great challenge for H5N1 vaccine candidate selection. The complexity of avian H5N1 viruses evolution raises an important issue for studying antigenic proper

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5

Vidaña, Mateo Beatriz. "Pathogenesis of 2009 pandemic influenza a virus (H1N1) infection in the ferret model." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/292487.

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La infección causada por el virus influenza A (VIA) causa una enfermedad aguda y recurrente con graves consecuencias sobre la salud pública mundial. El VIA es altamente contagioso y único entre las infecciones humanas presenta dos patrones epidemiológicos. Uno como epidemias estacionales anuales y otro como pandemias cada largo periodo de tiempo. En el 2009 se produjo la primera pandemia del siclo XXI, la cual presentó alta morbilidad causando más de 250.000 muertes alrededor del mundo. La mortalidad observada durante la pandemia fue similar a la observada en previas epidemias estacionales. Si

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6

DI, MARTINO ANGELA. "Genetic characteristics of the influenza A pandemic (h1n1) 2009 virus circulating in Italy." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1386.

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I virus influenzali sono responsabili di epidemie annuali e di più rare pandemie occasionali, che in passato hanno causato la morte di milioni di persone. La comparsa di nuovi ceppi virali rappresenta una continua minaccia per la salute pubblica e una sfida per la comunità scientifica. La recente pandemia influenzale, causata da un virus di sottotipo A/H1N1 di origine suina, costituisce un ulteriore strumento per lo studio dei fattori di virulenza e della diffusione dell'infezione in preparazione a futuri eventi pandemici. Nell'ambito dell’attività di sorveglianza virologica dell'influenza,

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7

Retamal, Miguel. "Génération d'anticorps monoclonaux neutralisants et dérive antigénique du virus influenza pandémique A(H1N1) 2009." Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27334.

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Encore aujourd'hui, la prévention de la grippe par la vaccination ou les approches thérapeutiques ne sont que partiellement efficaces. Les caractères d’hypervariabilité et de transmission du virus influenza lui permettent d’infecter les populations du monde entier malgré une immunité préexistante acquise par infection ou vaccination. En 2009 une éclosion de grippe A(H1N1) au Mexique s’est répandue mondialement et est devenue la pandémie A(H1N1)pdm09. Il devenait alors impératif d’étudier davantage ce virus influenza, notamment les sites antigéniques du virus qui sont les éléments clefs dans l’

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8

Miranda-Choque, Edwin, Carlos Ramírez, Jorge Candela-Herrera, et al. "Niños hospitalizados con neumonía por influenza AH1N11/2009 pandémico en un hospital de referencia de Perú." Instituto Nacional de Salud (INS), 2014. http://hdl.handle.net/10757/314691.

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Objetivos. Determinar las características clínicas y demográficas de la neumonía por el virus de influenza AH1N1/2009 pandémico en un hospital de referencia de Perú. Materiales y métodos. Se realizó un estudio serie de casos en niños hospitalizados por neumonía por influenza AH1N1/2009 pandémico en un hospital de referencia. Revisamos las historias clínicas entre los meses de junio a septiembre 2009. Todos los casos tuvieron confirmación virológica. Resultados. Se encontró 74 casos de neumonía por el virus de Influenza AH1N1/2009 pandémico (NVIp), de los cuales 50 tuvieron el diagnóstico

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9

Lemos, Daniele Rocha Queiroz. "CenÃrios de pandemia de Influenza A (H1N1) 2009 no CearÃ: padrÃes de morbimortalidade." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10220.

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INTRODUÃÃO - A gripe Ã uma doenÃa infecciosa aguda de origem viral, de distribuiÃÃo universal, que acomete o trato respiratÃrio. Segundo estatÃsticas da OrganizaÃÃo Mundial da SaÃde (OMS), cerca de 5 a 15% da populaÃÃo mundial se infecta com o vÃrus da influenza anualmente. Em marÃo de 2009, com mudanÃa no padrÃo da ocorrÃncia da influenza no MÃxico, o vÃrus da influenza A (H1N1), um quÃdruplo recombinante nunca antes visto, foi identificado atravÃs da anÃlise de amostras de secreÃÃo de nasofaringe de crianÃas americanas sintomÃticas, confirmando o vÃnculo epidemiolÃgico com os casos no MÃxico

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10

Delangue, Julie. "Etude de la pandémie grippale A/H1N1 2009 en France et en Bolivie." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5087.

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Par le passé les virus influenza A ont montré leur capacité d’émergence dans la population humaine. En 2009, l’apparition d’un nouveau variant réassortant a provoqué une pandémie. Ces travaux avaient pour objectifs d’étudier la propagation de la pandémie en France et Bolivie. Premièrement en Franve avec l’étude sérologique d’une population hospitalière et la surveillance hebdomadaire mise en place grâce au programme SéroGrippeHebdo. La séroprévalence prépandémique était de plus de 20% (au1/80) chez les plus de 60ans et de moins de 10% dans les autres groupes. Il a été possible de calculer un t

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11

Wong, Dik-yan Diana, and 黃廸欣. "Effect of the H275Y neuraminidase mutation on viral fitness of oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza Aviruses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617552.

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Neuraminidase (NA) inhibitors are one of two classes of antiviral compounds available for the control of influenza infections. The H275Y NA mutation confers resistance to the NA inhibitor oseltamivir carboxylate among the N1 influenza subtype and has been identified from resistant variants with distinct epidemiological outcomes in human. Specifically, dominance of oseltamivir-resistant variant of the A/Brisbane/59/2007-like viruses was reported during the 2008 to 2009 influenza season, until it was replaced by the 2009 pandemic H1N1 virus [A(H1N1)pdm09]. Since the emergence of the 2009 pandem

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12

Bouscambert-Duchamp, Maude. "Étude du réassortiment génétique des virus influenza d’origines et de sous-types différents." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10084/document.

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Dans le contexte de la menace pandémique liée au virus influenza A(H5N1), un projet «GRIPPE AVIAIRE ET GRIPPE PANDÉMIQUE » a émergé au sein de LyonBioPôle avec comme objectif le développement d’outils de caractérisation des virus influenza pour la production de vaccins. Pour étudier le réassortiment génétique entre virus influenza, nous avons développé 3 systèmes de génétique inverse : virus humain A(H3N2) et aviaires A(H5N2) et A(H5N1) et produit des virus réassortants de composition déterminée. Leurs capacités réplicatives ont été évaluées par cinétiques de croissance virale sur MDCK avec qu

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13

Martínez, Orellana Pamela Analía. "Analysis of host responses and fitness in different pandemic H1N1 (2009) influenza virus in mice and ferrets." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/145393.

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La gripe es un problema de salud pública en todo el mundo, siendo una de las enfermedades infecciosas más comunes y una patología de las vías aéreas altamente contagiosa. Desde abril de 2009, un nuevo virus de influenza A H1N1, con origen porcino dio lugar a la aparición de brotes en todo el mundo siendo declarada posteriormente como una situación de pandemia. Hoy en día el virus pdmH1N1 de 2009 continúa en circulación, generalmente provocando infecciones leves y autolimitadas. Sin embargo, un pequeño porcentaje de pacientes requieren hospitalización y atención especializada en la Unidad de C

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14

Siqueira, Giselle Angélica Moreira de. "EPIDEMIA DA INFLUENZA A (H1N1) 2009 NO ESTADO DE GOIÁS/BRASIL: CASOS E ÓBITOS." Pontifícia Universidade Católica de Goiás, 2013. http://tede2.pucgoias.edu.br:8080/handle/tede/4075.

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Submitted by admin tede (tede@pucgoias.edu.br) on 2018-11-19T16:59:56Z No. of bitstreams: 1 GISELLE ANGÉLICA MOREIRA DE SIQUEIRA.pdf: 1650143 bytes, checksum: 0a85747b640c1ee6d3c2dc446dececf7 (MD5)<br>Made available in DSpace on 2018-11-19T16:59:56Z (GMT). No. of bitstreams: 1 GISELLE ANGÉLICA MOREIRA DE SIQUEIRA.pdf: 1650143 bytes, checksum: 0a85747b640c1ee6d3c2dc446dececf7 (MD5) Previous issue date: 2013-12-19<br>SIQUEIRA, Giselle Angelica Moreira de. Epidemic Influenza A (H1N1) 2009 in the state of Goiás/Brazil: cases and deaths. Dissertation (MSc in Environmental Sciences) – Catholic U

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15

Guissa, Vanessa Ramos. "Imugenicidade e segurança da vacina contra influenza A H1N1/2009 em pacientes com dermatomiosite juvenil." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-03122013-113148/.

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Objetivos: Avaliar a imunogenicidade e segurança da vacina anti-influenza A/H1N1 2009 em pacientes com dermatomiosite juvenil (DMJ) comparados com controles saudáveis e a possível associação entre taxas de soroconversão com dados demográficos, enzimas musculares, escores da DMJ, linfopenia e tratamento nos pacientes com DMJ atendidos em dois serviços de Reumatologia Pediátrica. Métodos: Trinta pacientes com DMJ entre 9 e 21 anos e 81 controles saudáveis foram imunizados com a vacina anti-influenza A H1N1/2009 sem adjuvante. Todos foram avaliados pré e 21 dias após a vacinação. As taxas de soro

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16

Aikawa, Nádia Emi. "Imunogenicidade e segurança da vacina contra influenza A H1N1/2009 em pacientes com artrite idiopática juvenil." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-14122012-110037/.

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Introdução: A pandemia de gripe A H1N1 em junho de 2009 resultou em elevadas taxas de hospitalização entre pacientes imunodeprimidos, incluindo pacientes com artrite idiopática juvenil (AIJ). Embora a vacinação seja uma medida eficaz contra complicações da gripe pandêmica, não há estudos na literatura sobre seus efeitos na AIJ. Objetivos: Avaliar a resposta resposta da vacina contra influenza A H1N1/2009 sem adjuvante na AIJ, como uma extensão do estudo anterior de imunogenicidade e segurança em uma grande população de pacientes com doenças reumáticas juvenis. Além disso, avaliar a possível in

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17

Placzek, Hilary. "A Population-Based Epidemiological Description of Socio-Demographic Characteristics and Predictors of Severity Among Hospitalized 2009 H1N1 Influenza Cases in Massachusetts: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/602.

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The spread of pandemic influenza A (2009 H1N1 influenza) virus resulted in a global influenza pandemic in 2009. During the early stages of the pandemic, population surveillance was crucial. However, officials around the world realized that many of our surveillance and reporting systems were not prepared to respond in a coordinated, integrated way, which made informed public health decision-making very difficult. More accurate estimates of the total number of hospitalized 2009 H1N1 influenza cases were required to calculate population-based 2009 H1N1 influenza-associated mortality, morbidity an

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18

Paßvogel, Katharina [Verfasser]. "Generierung und Evaluierung rekombinanter Pseudorabies Virus basierter Vektor-Vakzine zur Immunisierung von Schweinen gegen das pandemische H1N1 Influenzavirus von 2009 / Katharina Paßvogel." Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1079278133/34.

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19

Nougairede, Antoine. "Pandémie grippale A/H1N1 2009/2010 : Diagnostic et épidémiologie au laboratoire hospitalier de microbiologie clinique à Marseille." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5000/document.

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Fin avril 2009, un nouveau virus grippal A/H1N1 d'origine porcine émerge dans le monde causant la première pandémie grippale du XXIème siècle. Les différents travaux présentés dans cette thèse retracent la gestion de cette situation au laboratoire de virologie des hôpitaux publics de Marseille. D'avril 2009 à avril 2010, nous avons analysé plus de 13 000 prélèvements issus de cas suspects. Nous avons dû adapter continuellement les moyens mis en œuvre pour effectuer le diagnostic et la mise en place d'une stratégie 'Point of Care' s'est avérée très utile. Nos résultats montrent que l'usage des

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20

Duff, Michael Alan. "Characterization of H1N2 variant influenza viruses in pigs." Thesis, Kansas State University, 2014. http://hdl.handle.net/2097/17392.

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Master of Science<br>Department of Diagnostic Medicine/Pathobiology<br>Wenjun Ma<br>With introduction of the 2009 pandemic H1N1 virus (pH1N1) into swine herds, reassortment between the pH1N1 and endemic swine influenza viruses (SIVs) has been reported worldwide. Recently, reassortant H3N2 and H1N2 variant SIVs that contain the M gene from pH1N1 virus and the remaining seven genes from North American triple-reassortant (TR) SIVs have emerged. These variant viruses have caused more than 300 cases of human infections and one death in the USA, creating a major public health concern. To date, the p

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21

Mendez, Rubio Saito Javier. "HALLAZGOS EN RADIOGRAFÍA DE TÓRAX DE PACIENTES DIAGNOSTICADOS POR SEROLOGÍA CON NEUMONÍA POR VIRUS DE LA INFLUENZA “A H1N1”, INTERNADOS EN EL “CENTRO MÉDICO LIC. ADOLFO LÓPEZ MATEOS”, EN EL PERIODO QUE COMPRENDE LOS MESES DE ENERO 2009 A DICIEMBRE 2011." Tesis de Licenciatura, Medicina-Quimica, 2013. http://ri.uaemex.mx/handle/20.500.11799/13971.

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22

Scarpa, Fernanda Cristina. "Epidemiologia do vírus influenza A (H1N1) em crianças internadas no serviço de pediatria do Hospital de Clínicas de Porto Alegre no ano de 2009." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/39656.

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Introdução: O surgimento de uma nova cepa do vírus Influenza A, o H1N1, determinou uma pandemia no ano de 2009, com importante repercussão global. Esse vírus infectou principalmente adultos jovens e crianças menores de dois anos com grande aumento na morbimortalidade quando comparado com as taxas anuais decorrentes do influenza. Objetivo: Avaliar as características epidemiológicas e clínicas da infecção pelo vírus influenza A (H1N1) em crianças, a fim de agregar conhecimento para melhor abordagem em futuras pandemias. Métodos: Estudo de corte transversal com revisão dos prontuários de todas as

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23

Neto, Rodrigo Antonio Brandão. "Pneumonia domiciliar associada a infecção pelo vírus p-H1N1 2009 em hospital terciário: frequência, características clínico-laboratoriais e aplicação de escores para predizer diagnóstico e prognóstico." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-18012013-114021/.

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Introdução: Em 13 de Setembro de 2009, a OMS reportou que existiam mais de 296.471 casos confirmados laboratorialmente de infecção pelo p-H1N1 2009. Ainda assim muitas questões permanecem, incluindo o papel de regras de probabilidade clínica e escores de gravidade de pneumonia adquirida na comunidade nestes pacientes. Nós descrevemos as características clínicas e epidemiológicas de pacientes internados por pneumonia adquirida na comunidade com ou sem infecção pelo p-H1N1. Objetivos: Verificar a incidência e características clínicas da pneumonia adquirida na comunidade associada com infecção pe

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24

Corrales, Cruz Edgar Alfredo. "Características clínico epidemiológicas de los pacientes que ingresaron al servicio de emergencia con neumonía severa asociada a infección por virus influenza A H1N1, en el Hospital de Emergencias Grau EsSalud, julio-diciembre 2009." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/12803.

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OBJETIVO: Describir las características clínicas y epidemiológicas al igual que la letalidad de los pacientes con neumonía severa asociada a infección por virus influenza A H1N1, que ingresaron al servicio de emergencia del Hospital de Emergencias Grau EsSalud de la ciudad de Lima, entre julio a diciembre del 2009. MATERIAL Y MÉTODOS: Estudio de tipo descriptivo de corte transversal, que incluyó a todos los pacientes mayores de 18 años de edad, con insuficiencia respiratoria aguda grave (IRAG) sospechoso de infección por virus influenza A H1N1 y neumonía severa asociada. Se realizó un regis

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25

Bouscambert-Duchamp, Maude. "Étude du réassortiment génétique des virus influenza d'origines et de sous-types différents." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00733681.

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Анотація:

Dans le contexte de la menace pandémique liée au virus influenza A(H5N1), un projet "GRIPPE AVIAIRE ET GRIPPE PANDÉMIQUE " a émergé au sein de LyonBioPôle avec comme objectif le développement d'outils de caractérisation des virus influenza pour la production de vaccins. Pour étudier le réassortiment génétique entre virus influenza, nous avons développé 3 systèmes de génétique inverse : virus humain A(H3N2) et aviaires A(H5N2) et A(H5N1) et produit des virus réassortants de composition déterminée. Leurs capacités réplicatives ont été évaluées par cinétiques de croissance virale sur MDCK avec qu

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26

Silva, Ivan Leonardo Avelino França e. "Imunogenicidade e segurança da vacina contra influenza A H1N1/2009 em pacientes com doenças reumáticas em uso de terapia anti-TNF alfa." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-25022015-145325/.

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\\OBJETIVOS: Avaliar a imunogenicidade e a segurança a curto prazo da vacina H1N1 pandêmica em pacientes com artrite reumatóide (AR) e espondiloartrites [ESa - artrite psoriática (AP) e espondilite anquilosante (EA)] recebendo classes distintas de terapia anti-TNF, assim como comparação com pacientes que receberam drogas modificadoras de doenças reumáticas (DMARDs) e controles saudáveis. MÉTODOS: Cento e vinte pacientes (AR, n=41; EA, n=57 e artrite psoriática - AP, n=22) em uso de agentes anti-TNF (monoclonal, n=94 e receptor solúvel, n=26) foram comparados com 116 pacientes com artrite infla

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27

Andayi, Fred Nyamwata. "Re-emerging human viral pathogens of the Republic of Djibouti(Africa) : Reporting on Pandemic Influenza A/H1N1/2009 and arboviruses epidemiology." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5013.

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Objectif de la thèse est de fournir République de Djibouti inventaire de la pandémie de grippe A/H1N1/2009-H1N1p et arbovirus hiver 2010. Elle a confirmé la capacité de surveillance locale pour détecter la grippe SG pic lors de la première vague de la pandémie, dont le profil était compatible avec H1N1p. Dans l'enquête CoPanFlu, une prévalence élevée (30%) de H1N1p a été confirmée par la jeune et District 4 résidents (plus de inégalités sociales) portant le plus lourd fardeau. Par conséquent, le contrôle futur de SG exigerait une approche queue pour atteindre des individus spécifiques et vulné

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Esteves, Souza Jerónimo, and Ríos Joaquín Javier Vela. "Efectos de una pandemia en los mercados de valores de renta variable: comparativa entre la Influenza de tipo A(H1N1) durante el periodo 2009- 2010 y el COVID-19 en el año 2019- 2020." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2020. http://hdl.handle.net/20.500.12404/18466.

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Después de la pandemia más conocida como la gripe española del año 1918, no hubo otra capaz de poner en serios problemas la economía mundial, en especial los mercados de valores de todos los países hasta la llegada del nuevo coronavirus SARS-COV2, denominado también COVID19. Por ello, el presente trabajo busca analizar y comparar los efectos de dos pandemias ocurridas en el periodo 2008-2020 en los mercados de renta de variable. Estas pandemias son la gripe A(H1N1) ocurrida en el periodo 2009- 2011 y el nuevo coronavirus SARS-COV2 que inició a finales del 2019 en Wuhan, China. El perio

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Blanchon, Thierry. "Utilisation des antiviraux dans le traitement de la grippe Oseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) virus infections Efficacy of oseltamivir-zanamivir combination compared to each monotherapy for seasonal influenza: a randomized placebo-controlled trial Factors associated with clinical and virological response in patients treated with oseltamivir or zanamivir for influenza A during the 2008-2009 winter Effect of oseltamivir, zanamivir or oseltamivir-zanamivir combination treatments on transmission of influenza in households Use of neuraminidase inhibitors in primary health care during pandemic and seasonal influenza between 2009 and 2013." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066742.

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Malgré les nombreuses études menées et les recommandations consensuelles au niveau international, la prescription des inhibiteurs de la neuraminidase (INA) en cas de syndrome grippal reste controversée. Cette thèse avait pour objectif de mieux comprendre la place qui devrait leur être réservée dans le traitement de la grippe saisonnière et pandémique. Afin de répondre à cette question, plusieurs travaux ont été menés et ont montré :-la moindre efficacité de l’association oseltamivir + zanamivir par rapport à l’oseltamivir seul dans le traitement des patients grippés pour réduire la durée de la

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Lee, Chia-Ling, and 李佳凌. "A Serological Study of Pandemic (H1N1) 2009 Influenza Virus." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/03911510018324293067.

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碩士<br>國立陽明大學<br>公共衛生研究所<br>98<br>A new influenza outbreak started from Mexico and United States in April, 2009 and became pandemic. The origin of this pandemic influenza virus was found to be a novel type A H1N1 reassortment strain. The influenza A virus genomes comprise eight negative-strained RNA, and encode various proteins with different functions. For influenza A virus, attachment infectivity hemagglutinin (HA) and neuraminidase (NA) proteins are important surface glycoproteins encoded by segment 4 and 6. The error-prone RNA-dependent RNA polymerase of influenza virus and the gene rearra

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BEČKOVÁ, Věra. "Nová varianta chřipky typu A ("Pandemic H1N1 2009") - problematika informovanosti o očkování v seniorském věku." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-79903.

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The theme of my thesis is the issue of the new strain of influenza A (H1N1 Pandemic 2009) and the associated awareness of vaccination amongst the elderly. The work is divided into two parts, a theoretical and practical part. In the theoretical part, I tried to comprehensively process the available knowledge on the origins, epidemiology and prevention of influenza with particular emphasis on vaccination, oriented towards the elderly. The practical part is focused on mapping the awareness of the elderly of the issue of vaccination against influenza and analysis of results from a research explora

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"Exploring the effect of school closure in mitigating transmission of pandemic (H1N1) 2009 in Hong Kong." 2012. http://library.cuhk.edu.hk/record=b5549097.

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學校停課在世界各國的流感大流行應對方案中常被列為一項社區緩疫措施，而這項措施亦在2009年H1N1流感大流行中被廣泛地使用。然而，這項緩疫措施經常被質疑是否恰當，原因是因為停課會對教育構成重大的影響，而且過往的流行病學硏究亦表示這項緩疫措施不一定有效。本論文硏究學校停課對2009年H1N1流感大流行在香港首5個月疫情中降低大流行流感傳播的效能。<br>在香港，在該大流行流感病毒於2009年4月在美國被發現後，香港政府實施了控疫措施(containment phase measures)，並開始對該流感大流行進行監測。為了判定大流行是否已在香港內蔓延，衛生防護中心設定了一個報告準則來讓本地醫生報告疑似大流行流感感染個案，並為每個懷疑個案作確診測試及為每個確診個案追溯感染源頭。當大流行流感在6月開始在香港內蔓延時，香港政府實施了緩疫措施(mitigation phase measures)。在緩疫措施底下，帶有流感病症的病人求診於指定流感診所和公共醫院急症室會被測試是否感染大流行流感，而停課措施亦在此時開始實行去減低大流行流感的傳播。停課措施一直維持至7月直至暑假開始，並經修改後於9月開學時繼續實行。在9月，鑑於已不再需要對流感大流行進行監測，對懷疑感染個案進行確診測試的政策止於該月下旬。確診個案中記錄了的病人資料，與及由學校停課和暑假所引起的學期變化，為這課題提供了一個理想硏究的機會

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Chen, Juine-Ruey, and 陳俊叡. "The Monoglycosylated Hemagglutinin from Seasonal Influenza H1N1 Is an Effective Vaccine with CrossProtective Immunity against Pandemic 2009 H1N1 Virus Infection in Mice." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/66305530721684589777.

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博士<br>國立陽明大學<br>生化暨分子生物研究所<br>98<br>Influenza pandemics occur when influenza hemagglutinins (HA) are little recognized by immunity and the viruses transmit efficiently from human to human. HA is the major viral surface glycoprotein that binds to specific sialylated glycan receptors in the respiratory tract and allows the virus to enter the cell. It has been recognized as the key antigen in the host immune response to influenza virus in both natural infection and vaccination. We have shown that HA with a single N-linked N-acetylglucosamine (GlcNAc) at each glycosylation sites (monoglycosylated

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Chou, Yu-Jen, and 周俞任. "Studies on the Function of PB1-F2 derived from Pandemic H1N1 2009 Influenza A Virus." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/27120420217899899529.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>99<br>Influenza A virus cause seasonal epidemic of disease worldwide every year. In March and early April 2009, a novel influenza A virus H1N1 emerged in the United States and Mexico, which was named pandemic H1N1 2009 influenza A virus (2009 H1N1). Tracing its phylogeny, scientists found its genome was reassorted from human, avain and swine flu. The viral protein PB1-F2 is another translated product which ribosome possesses a leaky scanning when it is scanning on the open reading frame (ORF) of PB1. Its length is about 87~90 a.a. PB1-F2 had multiple functions w

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Lai, Hsuan-yu, and 賴宣宇. "Production and characterization of the monoclonal antibodies against trimeric HA of 2009 H1N1 influenza virus." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/24138569058071470492.

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碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系暨研究所<br>99<br>Influenza A viruses have a lot of variants and usually cause pandemics worldwide. Influenza viruses infect cells through the interaction between hemagglutinin (HA) and sialic acid on cell membrane. The antibody is useful in prophylaxis, therapy, vaccine design and diagnosis. In this study the trimeric HA protein from A/Texas/05/2009 expressed by a baculovirus-insect expression system was intraperitoneally inoculated into Balb/c mice to produce antibodies. The GCN4 peptide derived from yeast transcription factor in the recombinant HA protein is to form t

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VELKOBORSKÁ, Marcela. "Příprava pandemického plánu - průběh pandemie chřipky způsobené virem Pandemic A (H1N1) 2009 v Plzeňském kraji." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-79732.

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An influenza is an illness annually affecting 5-15 percent of the world population. During the influenza pandemy 40-50 percent of world population can be affected and millions of people can die.The measures resulting from the pandemic plans help to limit the influenza virus spreading, to reduce morbidity and mortality. In April 2009 the first cases of the flue pandemic caused by Pandemic A (H1N1) 2009 virus occurred on the American continent, in the Czech Republic there was the first case registered in May, in the Pilsen region in July. Based on these facts I decided to assess the pandemic pla

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Hung, Ying-Nien, and 洪宜年. "A longitudinal study of cross-reactive antibody to swine influenza A virus (H3N2) and serologic evaluation of different influenza viruses after 2009 pandemic H1N1 in Taiwan." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/32660824464898926498.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>100<br>Introduction: Pigs play an important role in gene reassortment of the eight RNA segments of influenza viruses since they are susceptible to the viruses with both avian and human origin. Because of the great change of antigenicity, the reassorted viruses have the potential to cause global pandemic such as 2009 pandemic H1N1. As the reports of the increase of human infection by the newly-reassorted swine influenza viruses subtype H3N2 carrying genes from 2009 pandemic H1N1 were observed, it is crucial to understand the antibody cross-reactivity between swin

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Najar, Tariq Ahmad. "Design and Stabilization of Stem Derived Immunogens from HA of Influenza A Viruses." Thesis, 2015. http://etd.iisc.ernet.in/2005/3863.

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Influenza virus belongs to the Orthomyxovirus family of viruses that causes respiratory infection in humans, leading to morbidity and mortality. The mature influenza A virion has an envelope that contains two major surface glycoproteins proteins – hemagglutinin (HA) and neuraminidase (NA). HA is a highly antigenic molecules and is responsible binding to host cell surface receptors (Sialic acid), and membrane fusion between the viral membrane and the host endosomal membrane. Most of the antibody response generated against influenza virus either by vaccination or by natural infection is directed

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Najar, Tariq Ahmad. "Design and Stabilization of Stem Derived Immunogens from HA of Influenza A Viruses." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3863.

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Influenza virus belongs to the Orthomyxovirus family of viruses that causes respiratory infection in humans, leading to morbidity and mortality. The mature influenza A virion has an envelope that contains two major surface glycoproteins proteins – hemagglutinin (HA) and neuraminidase (NA). HA is a highly antigenic molecules and is responsible binding to host cell surface receptors (Sialic acid), and membrane fusion between the viral membrane and the host endosomal membrane. Most of the antibody response generated against influenza virus either by vaccination or by natural infection is directed

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