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Добірка наукової літератури з теми "Hcy"

Автор: Grafiati
Опубліковано: 10 січня 2023
Оновлено: 28 січня 2023

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Статті в журналах з теми "Hcy"

1

Latteri, Saverio, Giulia Malaguarnera, Vito Emanuele Catania, Gaetano La Greca, Gaetano Bertino, Antonio Maria Borzì, Filippo Drago, and Michele Malaguarnera. "Homocysteine Serum Levels as Prognostic Marker of Hepatocellular Carcinoma with Portal Vein Thrombosis." Current Molecular Medicine 19, no. 7 (August 2, 2019): 532–38. http://dx.doi.org/10.2174/1566524019666190610120416.

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Анотація:
Background: Portal vein thrombosis (PVT) is a common complication of endstage hepatocellular carcinoma (HCC). : The aim of our study was to evaluate the role of Homocysteine (Hcy) in HCC patient with PVT. Hcy is a sulphur amino-acid involved in two pathways, trans-sulphuration and remethylation, that involve vitamins B6, B12 and folates. Methods: We recruited 54 patients with HCC and PVT, 60 patients with HCC and without PVT and 60 control subjects. We measured serum levels of Hcy, folate, vitamins B6 and B12. Results: The comparison between HCC patients with PVT versus HCC without PVT was shown that mean values of Hcy were 6.4 nmol/L (p<0.0073) higher, LDL cholesterol were 4.8 mg/dl (p<0.0079) lower, vitamin B6 were 4.6 nmol/L(p=0.0544) lower, vitamins B 12 were 22.1 pg/ml (p=0.0001) lower. Conclusion: High serum levels of Hcy are an established thrombotic risk factor in the general population. We found significantly higher levels of Hcy in HCC patients with PVT versus both HCC patients without PVT and controls.
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2

Quinn, C. T., J. C. Griener, T. Bottiglieri, K. Hyland, A. Farrow, and B. A. Kamen. "Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer." Journal of Clinical Oncology 15, no. 8 (August 1997): 2800–2806. http://dx.doi.org/10.1200/jco.1997.15.8.2800.

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Анотація:
PURPOSE Folate deficiency, either by diet or drug, increases plasma homocysteine (Hcy). Hcy damages cerebrovascular endothelium, and hyperhomocysteinemia is a risk factor for stroke. Hcy is metabolized to excitatory amino acid (EAA) neurotransmitters, such as homocysteic acid (HCA) and cysteine sulfinic acid (CSA), which may cause seizures and excitotoxic neuronal death. We postulated that excess Hcy and EAA neurotransmitters may partly mediate methotrexate (MTX)-associated neurotoxicity. PATIENTS AND METHODS In this retrospective analysis, we used high-performance liquid chromatography (HPLC) to measure Hcy, HCA, and CSA in CSF from two groups of children: (1) a control group of patients with no MTX exposure, and (2) a treatment group of patients who had received MTX no more than 7 days before a scheduled lumbar puncture. RESULTS The treatment group had a significantly (P = .0255) greater concentration of Hcy in CSF (0.814 micromol/L +/- 0.215 [mean +/- SEM], n = 23) than the control group (0.210 micromol/L +/- 0.028, n = 34). HCA and CSA were not detected in CSF from control patients (n = 29); however, MTX caused marked accumulation of CSF HCA (119.1 micromol/L +/- 32.0, n = 16) and CSA (28.4 micromol/L +/- 7.7, n = 16) in the treatment group. Patients with neurologic toxicity at the time of lumbar puncture had many of the highest concentrations of Hcy, HCA, and CSA. CONCLUSION These data support our hypothesis that MTX-associated neurotoxicity may be mediated by Hcy and excitotoxic neurotransmitters.
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3

Yang, Modan, Winyen Tan, Xinyu Yang, Jianyong Zhuo, Zuyuan Lin, Beini Cen, Zhengxing Lian, et al. "Homocysteine: A novel prognostic biomarker in liver transplantation for alpha-fetoprotein- negative hepatocellular carcinoma." Cancer Biomarkers 29, no. 2 (October 9, 2020): 197–206. http://dx.doi.org/10.3233/cbm-201545.

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Анотація:
BACKGROUND: Precise recipient selection optimizes the prognosis of liver transplantation (LT) for hepatocellular carcinoma (HCC). Alpha-fetoprotein (AFP) is the most commonly used biomarker for diagnosis and prognosis of HCC in the clinical context. As a crucial molecule in methionine cycle, homocysteine (Hcy) level has been proved to be related to HCC progression and metastasis. OBJECTIVE: We aimed to explore the prognostic capacity of pre-transplant serum Hcy level in LT for HCC. METHODS: This study retrospectively enrolled 161 HCC patients who had underwent LT from donation after cardiac death (DCD) in the First Affiliated Hospital of Zhejiang University from 2015.01.01 to 2018.09.01. Pre-transplant serum Hcy level was incorporated into statistical analysis together with other clinical parameters and pathological features. RESULTS: From an overall perspective, significant difference was observed in Hcy level between recurrence (n= 61) and non-recurrence group (n= 100) though subsequent analysis showed unsatisfactory predicting performance. In the whole cohort, multivariate analysis showed that lnAFP (p= 0.010) and Milan criteria (MC, p< 0.001) were independent risk factors of HCC recurrence after LT. MA score based on MC and lnAFP performed well in predicting post-LT tumor recurrence with the AUROC at 0.836 (p< 0.001) and 3-year recurrence-free survival rate at 96.8% (p< 0.001) in the low risk group (n= 69). According to the clinical practice, serum concentration lower than 20 μg/L is considered as normal range of AFP. Elevated pre-transplant serum AFP (> 20 μg/L) predicts high HCC recurrence after LT. We further divided the 161 recipients into AFP- group (n= 77, AFP ⩽ 20 μg/L) and AFP+ group (n= 84, AFP > 20 μg/L). MA score was still well presented in the AFP+ group and the AUROC for tumor recurrence was 0.823 (p< 0.001), whereas the predicting accuracy was reduced in AFP- group (AUROC: 0.754, P< 0.001). After subsequent analysis, we found that elevated pre-transplant Hcy level (> 12.75 μmol/L) predicted increased tumor recurrence risk in AFP- group. The 3-year recurrence-free survival rates were 92.0% and 53.7% (p< 0.001) in low Hcy subgroup (n= 40) and high Hcy subgroup (n= 37) respectively. Multivariate analysis showed that Hcy (p= 0.040) and Milan criteria (p= 0.003) were independent risk factors for post-transplant tumor recurrence in AFP- group. Further combination of Hcy level and Milan criteria identified a subgroup of AFP- recipients with acceptable outcomes even though beyond Milan criteria (3-year recurrence-free survival rate: 77.7%, p< 0.001). CONCLUSION: As a classic predictor in HCC prognosis, AFP performed well in our study cohort when combined with Milan criteria. Homocysteine was an effective prognostic biomarker in LT for AFP- hepatocellular carcinoma. In recipients exceeding Milan criteria, acceptable post-transplant outcome could be seen in those with low Hcy and AFP level.
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4

Sikora, Marta, and Hieronim Jakubowski. "Homocysteine editing and growth inhibition in Escherichia coli." Microbiology 155, no. 6 (June 1, 2009): 1858–65. http://dx.doi.org/10.1099/mic.0.026609-0.

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Анотація:
In Escherichia coli homocysteine (Hcy) is metabolically converted to the thioester Hcy-thiolactone in ATP-consuming reactions catalysed by methionyl-, isoleucyl- and leucyl-tRNA synthetases. Here we show that growth inhibition caused by supplementation of E. coli cultures with Hcy is accompanied by greatly increased accumulation of Hcy-thiolactone. Energy dissipation for Hcy editing increases 100-fold in the presence of exogenous Hcy and reaches one mole of ATP unproductively dissipated for Hcy-thiolactone synthesis per each mole of ATP that is consumed for methionine activation. Inhibiting Hcy-thiolactone synthesis with isoleucine, leucine or methionine accelerates bacterial growth in Hcy-supplemented cultures. Growth rates in Hcy-inhibited cultures are inversely related to the accumulation of Hcy-thiolactone. We also show that the levels of protein N-linked Hcy modestly increase in E. coli cells in Hcy-supplemented cultures. The results suggest that Hcy editing restrains bacterial growth.
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5

Nozari, Samira, Nazila Fathi Maroufi, Mohammad Nouri, Mirhamid Paytakhti Oskouei, Javad Shiralizade, Farshid Yekani, Mina Mamipour, and Yousef Faridvand. "Decreasing serum homocysteine and hypocholesterolemic effects of bovine lactoferrin in male rat fed with high-cholesterol diet." Journal of Cardiovascular and Thoracic Research 10, no. 4 (December 11, 2018): 203–8. http://dx.doi.org/10.15171/jcvtr.2018.35.

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Анотація:
Introduction: Lipid metabolism disorder or hyperlipidemia is known as a risk factor for cardiovascular disease, the increase in serum homocysteine and leptin are associated with atherosclerotic disease. The purpose of the present study was to examine the effects of bovine lactoferrin (bLF) on serum homocysteine (Hcy), apolipoproteinA-I (ApoA-I) and B (ApoB), leptin and lipid profile changes in high-cholesterol-diet (HCD) fed rats. Methods: The Healthy Adult Sprague-Dawley (SD) male rats were randomly assigned into three experimental groups. Each group consisted of eleven male rats including control group, HCD rats and hypercholesterolemic rats, which were treated with bLF (HCD+bLF). bLF was given by gavage (200 mg/kg/d). After 4 weeks of feeding and overnight fasting, total blood samples were collected. Results: The results showed the elevated level of Hcy, leptin, total cholesterol, low density lipoprotein cholesterol (LDL-C), ApoB and decrease in ApoA-I in non-treated HCD group compared to the control rats. Administration of bLF significantly ameliorated the Hcy and leptin levels with decrease in LDL-C and total cholesterol in rats fed with a high-cholesterol diet. bLF also tended to increase low serum concentration of ApoA-I and high density lipoprotein cholesterol (HDL-C) in HCD rats. Meanwhile, upon bLF-treated rats, there was a significant decrease in ApoB in HCD group. Conclusion: The findings indicated that bLF can improve the alteration of serum Hcy, leptin, apolipproteins and lipid changes in male rats fed with high-cholesterol diet. So, bLF can counteract with HCD elicited hyper-homocysteinemia and hyper-leptinemia, suggesting it to have the useful therapeutic potential in patients with atherosclerosis and lipid disorder.
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6

Chwatko, Grazyna, and Hieronim Jakubowski. "Urinary Excretion of Homocysteine-Thiolactone in Humans." Clinical Chemistry 51, no. 2 (February 1, 2005): 408–15. http://dx.doi.org/10.1373/clinchem.2004.042531.

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Анотація:
Abstract Background: A metabolite of homocysteine (Hcy), the thioester Hcy-thiolactone, has been implicated in coronary heart disease in humans. Because inadvertent reactions of Hcy-thiolactone with proteins can lead to cell and tissue damage, the ability to detoxify or eliminate Hcy-thiolactone is essential for biological integrity. We examined the hypothesis that the human body eliminates Hcy-thiolactone by urinary excretion. Methods: We used a sensitive HPLC method with postcolumn derivatization and fluorescence detection to examine Hcy-thiolactone concentrations in human urine and plasma. Results: We discovered a previously unknown pool of Hcy-thiolactone in human urine. Urinary concentrations of Hcy-thiolactone (11–485 nmol/L; n = 19) were ∼100-fold higher than those in plasma (&lt;0.1–22.6 nmol/L; n = 20). Urinary Hcy-thiolactone accounted for 2.5–28.3% of urinary total Hcy, whereas plasma Hcy-thiolactone accounted for &lt;0.002–0.29% of plasma total Hcy. Urinary concentrations of Hcy-thiolactone, but not of total Hcy, were negatively correlated with urinary pH. Clearance of Hcy-thiolactone, relative to creatinine, was 0.21–6.96. In contrast, relative clearance of Hcy was 0.001–0.003. Conclusions: The analytical methods described here can be used to quantify Hcy-thiolactone in biological fluids. Using these methods we showed that the human body eliminates Hcy-thiolactone by urinary excretion. Our data also suggest that the protonation status of its amino group affects Hcy-thiolactone excretion.
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7

Huang, An, John T. Pinto, Ghezal Froogh, Sharath Kandhi, Jun Qin, Michael S. Wolin, Thomas H. Hintze, and Dong Sun. "Role of homocysteinylation of ACE in endothelial dysfunction of arteries." American Journal of Physiology-Heart and Circulatory Physiology 308, no. 2 (January 15, 2015): H92—H100. http://dx.doi.org/10.1152/ajpheart.00577.2014.

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Анотація:
The direct impact of de novo synthesis of homocysteine (Hcy) and its reactive metabolites, Hcy-S-S-Hcy and Hcy thiolactone (HCTL), on vascular function has not been fully elucidated. We hypothesized that Hcy synthesized within endothelial cells affects activity of angiotensin-converting enzyme (ACE) by direct homocysteinylation of its amino- and/or sulfhydryl moieties. This covalent modification enhances ACE reactivity toward angiotensin II (ANG II)-NADPH oxidase-superoxide-dependent endothelial dysfunction. Mesenteric and coronary arteries isolated from normal rats were incubated for 3 days with or without exogenous methionine (Met, 0.1–0.3 mM), a precursor to Hcy. Incubation of arteries in Met-free media resulted in time-dependent decreases in vascular Hcy formation. By contrast, vessels incubated with Met produced Hcy in a dose-dependent manner. There was a notably greater de novo synthesis of Hcy from endothelial than from smooth muscle cells. Enhanced levels of Hcy production significantly impaired shear stress-induced dilation and release of nitric oxide, events that are associated with elevated production of vascular superoxide. Each of these processes was attenuated by ANG II type I receptor blocker or ACE and NADPH oxidase inhibitors. In addition, in vitro exposure of purified ACE to Hcy-S-S-Hcy/HCTL resulted in formation of homocysteinylated ACE and an enhanced ACE activity. The enhanced ACE activity was confirmed in isolated coronary and mesenteric arteries that had been exposed directly to Hcy-S-S-Hcy/HCTL or after Met incubation. In conclusion, vasculature-derived Hcy initiates endothelial dysfunction that, in part, may be mediated by ANG II-dependent activation of NADPH oxidase in association with homocysteinylation of ACE.
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8

Kornjaca, Dusko, Vladimir Zivkovic, Danijela Krstic, Mirjana Colovic, Marko Djuric, Sanja Stankovic, Slavica Mutavdzin, Vladimir Jakovljevic, and Dragan Djuric. "The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat." Archives of Biological Sciences 70, no. 2 (2018): 241–48. http://dx.doi.org/10.2298/abs170731041k.

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Анотація:
The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9% NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLHC significantly inhibited AChE activity in rat cardiac tissue. Our findings suggest that DL-Hcy and DL-Hcy TLHC exerted prooxidant effects; however, the decrease in MDA points to an inverse response to the increase in antioxidant enzyme activities. While both substances inhibited AChE activity in rat cardiac tissue, DL-Hcy TLHC induced stronger effects than DL-Hcy.
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9

Lominadze, David, Andrew M. Roberts, Neetu Tyagi, Karni S. Moshal, and Suresh C. Tyagi. "Homocysteine causes cerebrovascular leakage in mice." American Journal of Physiology-Heart and Circulatory Physiology 290, no. 3 (March 2006): H1206—H1213. http://dx.doi.org/10.1152/ajpheart.00376.2005.

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Анотація:
Elevated plasma homocysteine (Hcy) is associated with cerebrovascular disease and activates matrix metalloproteinases (MMPs), which lead to vascular remodeling that could disrupt the blood-brain barrier. To determine whether Hcy administration can increase brain microvascular leakage secondary to activation of MMPs, we examined pial venules by intravital video microscopy through a craniotomy in anesthetized mice. Bovine serum albumin labeled with fluorescein isothiocyanate (BSA-FITC) was injected into a carotid artery to measure extravenular leakage. Hcy (30 μM/total blood volume) was injected 10 min after FITC-BSA injection. Four groups of mice were examined: 1) wild type (WT) given vehicle; 2) WT given Hcy (WT + Hcy); 3) MMP-9 gene knockout given Hcy (MMP-9−/− + Hcy); and 4) MMP-9−/− with topical application of histamine (10−4 M) (MMP-9−/− + histamine). In the WT + Hcy mice, leakage of FITC-BSA from pial venules was significantly ( P < 0.05) greater than in the other groups. There was no significant leakage of pial microvessels in MMP-9−/− + Hcy mice. Increased cerebrovascular leakage in the MMP-9−/− + histamine group showed that microvascular permeability could still increase by a mechanism independent of MMP-9. Treatment of cultured mouse microvascular endothelial cells with 30 μM Hcy resulted in significantly greater F-actin formation than in control cells without Hcy. Treatment with a broad-range MMP inhibitor (GM-6001; 1 μM) ameliorated Hcy-induced F-actin formation. These data suggest that Hcy increases microvascular permeability, in part, through MMP-9 activation.
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10

Tuite, Nina L., Katy R. Fraser, and Conor P. O'Byrne. "Homocysteine Toxicity in Escherichia coli Is Caused by a Perturbation of Branched-Chain Amino Acid Biosynthesis." Journal of Bacteriology 187, no. 13 (July 1, 2005): 4362–71. http://dx.doi.org/10.1128/jb.187.13.4362-4371.2005.

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Анотація:
ABSTRACT In Escherichia coli the sulfur-containing amino acid homocysteine (Hcy) is the last intermediate on the methionine biosynthetic pathway. Supplementation of a glucose-based minimal medium with Hcy at concentrations greater than 0.2 mM causes the growth of E. coli Frag1 to be inhibited. Supplementation of Hcy-treated cultures with combinations of branched-chain amino acids containing isoleucine or with isoleucine alone reversed the inhibitory effects of Hcy on growth. The last intermediate of the isoleucine biosynthetic pathway, α-keto-β-methylvalerate, could also alleviate the growth inhibition caused by Hcy. Analysis of amino acid pools in Hcy-treated cells revealed that alanine, valine, and glutamate levels are depleted. Isoleucine could reverse the effects of Hcy on the cytoplasmic pools of valine and alanine. Supplementation of the culture medium with alanine gave partial relief from the inhibitory effects of Hcy. Enzyme assays revealed that the first step of the isoleucine biosynthetic pathway, catalyzed by threonine deaminase, was sensitive to inhibition by Hcy. The gene encoding threonine deaminase, ilvA, was found to be transcribed at higher levels in the presence of Hcy. Overexpression of the ilvA gene from a plasmid could overcome Hcy-mediated growth inhibition. Together, these data indicate that in E. coli Hcy toxicity is caused by a perturbation of branched-chain amino acid biosynthesis that is caused, at least in part, by the inhibition of threonine deaminase.
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Більше джерел

Дисертації з теми "Hcy"

1

Ernest, Sheila. "Genetic and Molecular Dissection of Homocysteinemia in Mice." Case Western Reserve University School of Graduate Studies / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=case1085436351.

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2

Alkhoury, Kenan. "Mechanisms responsible for homocysteine mediated damage to human endothelial cells : the role of oxidative stress in atherogenesis." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4300.

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Анотація:
Homocysteine (Hcy) has been identified as a primary risk factor for atherosclerosis as it induces endothelial cell (EC) activation/dysfunction and thus potentially initiating atherosclerotic plaque formation. There is accumulating evidence indicating a key role for oxidative stress in mediating Hcy atherogenic effects. The aim of this study was to evaluate the effects of chronic treatment with Hcy on EC activation and to explore the role of oxidative stress in these effects. Human umbilical vein endothelial cells (HUVEC) were cultured and treated chronically with DL-Hcy for 5-9 days. An in vitro flow system was also used to characterize the different types of interactions between DL-Hcy-treated HUVEC and neutrophils under physiological flow conditions. EC activation was studied by characterizing the activation of the JNK pathway and the up-regulation of different cell adhesion molecules (CAM) and cytokines, using different techniques including western blot, immunohistochemical staining, enzyme-linked immunosorbent assay and polymerase chain reaction. The role of oxidative stress was investigated by measuring the production of ROS and evaluating the efficiency of antioxidants. Furthermore, the role of nitric oxide and nitric oxide synthase in modulating Hcy effects was investigated. Chronic treatment with DL-Hcy did not kill the EC however, it inhibited cell proliferation. Furthermore, this treatment induced EC activation/dysfunction which was characterized by sustained activation of the JNK pathway, which in turn mediated up-regulation of E-selectin, ICAM-1 and to lesser extent P-selectin. Furthermore, DL-Hcy induced production of IL-8 protein. These CAM and chemokines collectively mediated different interactions between DL-Hcy-treated HUVEC and neutrophils under flow conditions including tethering, rolling, adherence and transmigration. DL-Hcy was also shown to induce significant ROS generation which mediated activation of the JNK pathway. Antioxidants restored DL-Hcy-induced interactions under flow to the basal level. DL-Hcy was shown to induce eNOS uncoupling which mediated, at least in part, the DL-Hcy-induced ROS production. Furthermore, short term treatment with NO inhibited DL-Hcy-induced HUVEC:neutrophil interactions in a cGMP-independent manner. In summary, this research showed that DL-Hcy has several proatherogenic effects, mediated at least in part by the JNK pathway, and induces EC activation/dysfunction priming for atherosclerosis initiation. The data supports that oxidative stress mediates the majority of Hcy atherosclerotic effects. Antioxidants tested, JNK inhibitors and NO showed promising results in reversing all DL-Hcy effects and restoring EC normal status.
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3

Alles, Roxane. "Développement de nouveaux nanovecteurs pour les thérapies anti-HCV/HCC." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00998936.

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Анотація:
Ce travail concerne le développement d'un système de vectorisation nanoparticulaire pour l'interférence ARN, constituant une nouvelle proposition thérapeutique applicable à des pathologies virales ou tumorales, et possiblement complémentaire aux traitements existants. La vectorisation de siRNA est ici basée sur l'enrobage multicouche de nanoparticules de phosphate de calcium, la multicouche étant constituée de dépôts alternés de PEI modifié et de siRNA. Ce système permet d'obtenir une efficacité de transfection des cellulaires cibles supérieure à celle des procédés conventionnels et une rémanence fonctionnelle in vitro jusqu'à neuf jours. Les résultats d'interférence ARN obtenus ont permis notamment d'inhiber l'infection par le virus de l'hépatite C jusqu'à 99,95%, l'inhibition de l'expression d'une protéine intrinsèque jusqu'à90,5%, et le ralentissement de la croissance cellulaire dans un modèle 3D mimant une tumeur hépatique jusqu'à 46,5%. Ces nanoparticules pourraient présenter un intérêt majeur, en offrant une action à long terme et en résolvant la plupart des difficultés rencontrées en utilisant des siRNA en thérapie.
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4

Ahmed, Iqra Shahzadi. "Preventing the spread of Tuberculosis via refugees, asylum seekers and immigrants entering Sweden : A study of health communication, prevention strategies, policies and recommendations." Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-20183.

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Анотація:
Sverige har under många decennier sett en minskning av tuberkulos (TBC), men infektionen har kontinuerligt ökat från 2003. Majoriteten av TBC-fallen är personer som är födda utanför Sverige. Hälsotillståndet har förbättrats i Sverige men det finns fortfarande problem. Kommunikationen mellan flyktingar och sjukvårdsspecialister är bristande idag, vilket resulterar att endast ett fåtal genomgår hälsokontroller. Detta kan leda till en ökning av infektioner och sjukdomar i Sverige. Denna studie undersöker hur hälsokommunikationen idag fungerar mellan den svenska sjukvården, nyanlända immigranter, asylsökande och flyktingar, samt vilken typ av vård som finns tillgänglig för flyktingar med hög risk för att utveckla TBC. Specifikt syftar studien till att förstå på vilket sätt kommunikation brister på samt analysera vilka sätt det finns för att en reducering av TBC i Sverige ska kunna ske och hur kommunikationen kan förbättras. Studien har genomförts med hjälp av både primära källor i form av intervjuer och sekundära källor. Baserat på de intervjuer och sekundära källor som genomförts i studien dras slutsatsen att trots att den svenska sjukvården utvecklas positivt så finns det en hel del brister - hälsokommunikation är bristande idag mellan nyanlända flyktingar, sjukvårdspersonal och myndigheter. En av huvudorsakerna som informanterna i studien nämnt är språket, mycket av det som skrivs och sägs är på svenska. Det är viktigt att en mer välfungerad hälsokommunikation utvecklas mellan de nyanlända flyktingarna, sjukvårdspersonal och myndigheterna för att det ska kunna underlättas för flyktingar att söka vård och samarbeta med sjukvårdspersonal med deras arbete för att kunna förhindra spridning av TBC och andra sjukdomar och infektioner i Sverige.
Sweden has for many decades witnessed a decrease of the spread of tuberculosis (TB), but between the years of 2003-2012 a new pattern has emerged with refugees carrying TB entering the country and contributing to a situation where the infection has slowly begun to spread again. The communication between the refugees and the health professionals has been inefficient, which inevitably results in fewer refugees undergoing health examinations. This in turn can lead to an increase of infections and diseases. The purpose of this study is to examine the current health communication between Swedish health professionals and immigrants, asylum seekers and refugees, and to give an overview of what type of health care currently exist for refugees with a high risk of TB. This is done to understand what is missing in the communication process, what has been done in order to improve the situation, and how it can be further improved in order to prevent TB. In order to fulfill the purpose of this study, a qualitative method has been used combining text analysis of interviews and secondary sources. This study has shown based on the interviews and secondary sources that the Swedish prevention work regarding TB is developing positively in general, but the communication between newly arrived refugees, health professionals and authorities in Sweden is lacking due to the fact that most of what is written and said in this communication process is in Swedish. This makes it difficult for the refugees to understand what is communicated and is stated as one of the main reasons why many refugees do not undergo health examinations, combined with the lack of awareness. Therefore a better functioning health communication between refugees, authorities and health professionals is required to support refugees seeking health care, as well as co-operating with health professionals to prevent the spread of not only TB but other infections and diseases in Sweden.
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El-Nady, Ghada Maghawry Abdel-Latif. "Gene expression in HCV-associated HCC-identification of an UP-regulated gene encoding A protein related to ubiquitin conjugating enzyme." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268862.

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6

Silva, Jefferson José Soares da. "Ligação de hidrogênio intermolecular entre o benzeno e as espécies doadoras de próton: HF, HCl, HCN, H2O, NH3, CH4 E C2H6." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8208.

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Made available in DSpace on 2016-05-18T11:30:52Z (GMT). No. of bitstreams: 1 arquivo total.pdf: 3924761 bytes, checksum: 10fd32043ab09f5cc3f02a7885814b08 (MD5) Previous issue date: 2015-06-30
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
This work deals with the computational quantum study of structural, electronic , vibrational and topological properties of hydrogen complexes C6H6•••HX , with proton, donor species , HF , HCl , H2O , HCN , NH3 , CH4 and C2H6 , interacting with a region of high electron density of the type π present in benzene. The computational methods of electronic structure Density Functional Theory with Hybrid functional B3LYP and PBE1PBE and Perturbative Theory of Many Bodies of order 2 were employed, all with the Pople basis set 6-311 ++ G ( d, p ) . The values of hydrogen bonding energy were submitted to Basis set superposition error and Vibrational Zero Point Energy corrections. The complexes of hydrogen HF, HCl, HCN, H2O and NH3 showed increments in H-X bond length, while CH4 and C2H6 have presented a shortening, H-C bond length due to formation of the intermolecular bond. The corrected intermolecular energy values follow the reverse trend of the values obtained for the increase, in H-X bond length. With the exception of ethane, all redshift values are positive, with higher values when the symmetry was not fixed. The employment of quantum theory of atoms in molecules shows the change in electron density of both interacting species, and in addition the density values are small and the density of the Laplacian are positive. The methods followed the same trend for the properties of interest, suggesting the use of calculations via density functional theory due to lower computational requirements, to study such systems.
Este trabalho trata do estudo quântico computacional de propriedades estruturais, eletrônicas, vibracionais e topológicas dos complexos de hidrogênio C6H6•••H-X, com as espécies doadoras de próton, HF, HCl, H2O, HCN, NH3, CH4 e C2H6, interagindo com uma região de alta densidade eletrônica do tipo π presente no benzeno. Os métodos computacionais de estrutura eletrônica empregados foram a Teoria do Funcional da Densidade com os funcionais híbridos B3LYP e PBE1PBE e a Teoria Perturbativa de Muitos Corpos de ordem 2, todos com o conjunto de base de Pople 6-311++G(d,p). Os valores da energia da ligação de hidrogênio sofreram correções do Erro de Superposição do Conjunto de Funções de Base e da Energia Vibracional do Ponto Zero. Os complexos de hidrogênio com HF, HCl, HCN, H2O e NH3 apresentaram incrementos no comprimento da ligação H-X, enquanto o CH4 e o C2H6 chegaram a apresentar encurtamento do comprimento de ligação H-C, devido a formação da ligação intermolecular. Os valores de energia intermolecular corrigida seguem a tendência inversa dos valores obtidos para o incremento do comprimento de ligação H-X. Com exceção do etano, todos os valores redshift são positivos, apresentando valores mais elevados quando a simetria não foi fixada. O emprego da teoria quântica de átomos em moléculas evidencia a mudança na densidade eletrônica de ambas as espécies interagentes, e, além disso os valores da densidade são pequenos e do laplaciano da densidade são positivos. Os métodos empregados seguiram a mesma tendência para as propriedades de interesse, sugerindo o uso de cálculos via teoria do funcional da densidade, devido a menor demanda computacional, para estudar sistemas desse tipo.
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7

Yun, Tae-Jung. "Using ubiquitous communication technology to improve pediatric asthma management." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44794.

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Information and communication technologies (ICTs) for chronic care are increasingly being researched in Human-Computer Interaction. One of the current health management areas where ICTs have been employed is in supporting communications between patients and physicians. This is particularly relevant for patients suffering from chronic diseases since there is evidence that better communication leads to better health outcomes. Researchers are investigating different chronic diseases to design and test technology interventions to promote better chronic disease care. However, few have investigated pediatric asthma as a case study for designing communication technologies. The World Health Organization (WHO) estimated in 2008 that 300 million people suffer from asthma, and that asthma is the most common chronic illness among children. Asthma interferes with breathing by preventing airflow into the lungs. It is difficult to determine the actual cause of asthma and to predict who will have asthma. These unique challenges provide opportunities to investigate pediatric asthma management. To address these challenges, I have conducted a series of studies with pediatric asthma patients, families, and healthcare providers to better understand their needs, challenges and strategies regarding the use of technologies. I have conducted interviews, a focus group, and a technology probe study to create and refine initial technology designs for children with asthma and their caregivers. Based on the Health Belief Model (HBM), patient-provider communications, and my findings in the prior studies, I designed a mobile and web service to increase asthma knowledge and symptom/management awareness in the child for better health outcomes, and to affect the perceived quality of interaction with healthcare providers. I show the results of my two field deployment studies with total 65 patients to learn how the system affected their practices and health outcomes. My contributions come from an increased understanding in three areas: physician-patient communication via a mobile and web services; ubiquitous communication technology designs to improve current pediatric asthma practices; and controlled evaluation of a ubiquitous communication technology, SMS, in the field.
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8

Livedalen, Rachel Lynn. "Hey! Hey! What ever happened to the garden?" Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/4680.

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Femininity, in its normative socially driven state, is not a natural trait but a ghost that bears its past incarnations. I am interested in gender as a haunting social apparatus. Gender roles and representations have shifted throughout history, yet remain firmly attached to their antecedents. My creative research focuses on femininity as set forth in religion, social practices, and cultural phenomena and how these forces intersect at the present moment to create a complicated relationship of gender identity and expectations.
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9

Domiňáková, Michaela. "Architektura hry." Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2020. http://www.nusl.cz/ntk/nusl-432920.

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Thesis use principles of play to reconstruct school building realized in the second half of the 20th Century. More broadly it deals with current state and conditions for reconstruction of modernist school buildings in Slovakia. According to Huizinga, play as such is older than culture and was a factor that stimulated the creation of culture and assumed the formation of human society. Free play is an instinct, a fundamental right, inherent in children, and a developed mechanism for acquiring skills and promoting learning. In the early 20th century, in a context marked by the horrors of war and the experience of the wild industrialization of the 19th century, society began to focus on the rights and education of children. This change in approach to childhood and children in general has been transcribed into theoretical and practical forms of architecture, from the scale of urbanism to the scale of an element of public space or domestic space. The concept of play began to penetrate into forms of education. In connection with urban transformation and housing construction playground have been created, which function should be the one of an institutionalized space education, but also of security or control. The same principles of control were also included in the architecture of other institutions such as schools. Project understands reconstruction of the school building not only as its annex or aesthetization but rather as reconfiguration and reinterpretation of its former principles.
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10

Skálová, Alena. "Opakované hry." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-1669.

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Diplomová práce se snaží poskytnout ucelený pohled na známé poznatky z oblasti teorie opakovaných jako části teorie her. Teoretická část se zabývá předpoklady, výpočetními principy a rovnovážnými strategiemi pro opakované hry. V praktické části je teorie aplikována na oblast petrochemického průmyslu, konkrétně na konkurenci dvou čerpacích stanic v rámci prostorově vymezeného trhu.
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Книги з теми "Hcy"

1

Terban, Marvin. Hey, hay!: A wagonful of funny homonym riddles. New York: Clarion Books, 1991.

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2

Helms, Harry L. High-speed (HC/HCT) CMOS guide. Englewood Cliffs, N.J: Prentice Hall, 1989.

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3

Instruments, Texas. HC-HCT logic high-speed CMOS data book. [s.l.]: Texas Instruments, 1997.

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4

Casati, Rebecca. Hey Hey Hey: Roman. 2nd ed. München: Diana, 2001.

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5

Deary, Terry. 10 huyền thoại Hy Lạp hay nhất mọi thời đại. T.P. Hồ Chí Minh: Nhà xuất bản Trẻ, 2013.

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6

Ayverdi, Sâmiha. Hey gidi günler, hey. Gaziosmanpaşa, Ankara: Hülbe, 1988.

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7

Thor, Heyerdahl. hey. Bethesda, Md: Adler & Adler, 1986.

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8

Voskovec, Jiří. Hry. Praha: Československý spisovatel, 1985.

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9

Paul, Muldoon. Hay. New York: Farrar, Straus, Giroux, 1999.

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10

Walter, Moers. Hey! Frankfurt am Main, Germany: Eichborn, 1993.

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Частини книг з теми "Hcy"

1

Wright, M. C. H., J. M. Marr, and D. C. Backer. "Hat Creek HCO+ and HCN Observations of SgrA." In The Center of the Galaxy, 407–10. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-2362-1_54.

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2

Orsi, Franco. "HCC." In Locoregional Tumor Therapy, 31–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-36572-0_4.

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3

Orsi, Franco. "HCC." In Locoregional Tumor Therapy, 43–82. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-69947-9_3.

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4

Brown, J. M. "HCS." In Landolt-Börnstein - Group II Molecules and Radicals, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11313410_64.

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5

Long, John, Steve Cummaford, and Adam Stork. "HCI." In HCI Design Knowledge, 3–12. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-79209-0_1.

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6

Metze, Dieter, Vanessa F. Cury, Ricardo S. Gomez, Luiz Marco, Dror Robinson, Eitan Melamed, Alexander K. C. Leung, et al. "HCM." In Encyclopedia of Molecular Mechanisms of Disease, 777. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8577.

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7

Metze, Dieter, Vanessa F. Cury, Ricardo S. Gomez, Luiz Marco, Dror Robinson, Eitan Melamed, Alexander K. C. Leung, et al. "HCC." In Encyclopedia of Molecular Mechanisms of Disease, 777. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8728.

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8

Metze, Dieter, Vanessa F. Cury, Ricardo S. Gomez, Luiz Marco, Dror Robinson, Eitan Melamed, Alexander K. C. Leung, et al. "HCI." In Encyclopedia of Molecular Mechanisms of Disease, 777. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8846.

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9

Metze, Dieter, Vanessa F. Cury, Ricardo S. Gomez, Luiz Marco, Dror Robinson, Eitan Melamed, Alexander K. C. Leung, et al. "HCD." In Encyclopedia of Molecular Mechanisms of Disease, 777. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8848.

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10

Talbi, D., and Y. Ellinger. "A Theoretical Study of the HCO+ and HCS+ Electronic Dissociative Recombinations." In Dissociative Recombination, 59–66. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2976-7_6.

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Тези доповідей конференцій з теми "Hcy"

1

Yu, Yi. "IDDF2020-ABS-0054 Clinical study on the changes of serum Hcy and PC in patients with crohn’s disease." In Abstracts of the International Digestive Disease Forum (IDDF), 22–23 November 2020, Hong Kong. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2020. http://dx.doi.org/10.1136/gutjnl-2020-iddf.56.

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2

Sianipar, Imelda Rosalyn, Irena Ujianti, Sophie Yolanda, Aditya K. Murthi, Patwa Amani, and Dewi Irawati Soeria Santoso. "Developing vitamin B12 deficient rat model based on duration of restriction diet: Assessment of plasma vitamin B12, homocysteine (Hcy), and blood glucose levels." In SECOND INTERNATIONAL CONFERENCE OF MATHEMATICS (SICME2019). Author(s), 2019. http://dx.doi.org/10.1063/1.5096672.

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3

North, Steve. "Hey, where's my hay?" In ACI2017: Fourth International Conference on Animal-Computer Interaction. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3152130.3152149.

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4

Bolelli, G., V. Cannillo, L. Lusvarghi, E. Soragni, A. Loreto, and T. Valente. "A Comprehensive Characterization of Industrially Manufactured Hard Chrome Platings and of Thermally Sprayed Alternatives." In ITSC2005, edited by E. Lugscheider. Verlag für Schweißen und verwandte Verfahren DVS-Verlag GmbH, 2005. http://dx.doi.org/10.31399/asm.cp.itsc2005p1456.

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Abstract HVOF-sprayed coatings (WC-17Co, WC-10Co-4Cr, Co-28Mo-17Cr-3Si) have been compared with various kinds of industrially manufactured hard chrome coatings (HCC), whose substrate preparation, deposition process, post deposition treatments greatly affect their characteristics. Microstructure, micromechanical properties, tribological behaviour and corrosion resistance (electrochemical polarization tests and Corrodkote test) have been studied. HVOF-sprayed cermets are harder but less tough than HCC, Co-28Mo-17Cr-3Si are less hard than HCC. Splats detachment causes a comparable or higher mass loss in three-body abrasion than HCC coatings. Forming a uniform surface film, cermet coatings definitely overcome HCC in two-body sliding, while Co-28Mo-17Cr-3Si has insufficient hardness to display good sliding wear resistance. HVOF coatings show no passivation in corrosive media but cermets posses more noble corrosion potentials than HCC, and undergo generalized corrosion in HNO3 and HCl, with similar corrosion current densities (IC). HCC passivate and resist well in HNO3 0.1N, but undergo pitting corrosion in 0.1N HCl. Definitely different EC and IC are recorded for various HCC in HCl. HVOF-sprayed cermet coatings show lower IC in 0.1N HCl solution than several kinds of HCC. No visible damage occurs on HVOF-sprayed coatings after the Corrodkote test, while non de-hydrogenated HCC suffered pitting corrosion.
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5

Chang-Hasnain, Connie J. "Metastructured Optics Progress and Applications." In JSAP-OSA Joint Symposia. Washington, D.C.: Optica Publishing Group, 2021. http://dx.doi.org/10.1364/jsap.2021.10a_n405_1.

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Vertical cavity surface emitting lasers (VCSELs) have long been predicted as low-cost enabling laser sources for many applications including optical communications, sensing and imaging. Traditional VCSELs use distributed Bragg reflectors (DBRs) as mirrors, which consist of many tens layers of epitaxy layers with alternating refractive indecies. Snice 2004, we develeoped a new class of planar optics has emerged using near-wavelength dielectric structures, known as high contrast metastructures (HCM). Many extraordinary properties can be designed top-down based for integrated optics on a silicon or GaAs substrate. The one-dimensional version, a single layer high index contrast near-wavelength gratings (HCG), has been used to replace the hundred-layered DBR in a VCSEL structure. In this talk, I will review recent results using HCG/HCM in device applications of VCSELs, beam-steering optical phased array, biosensor, 4-wave generation, and spatial light modulator. I will discuss inventions and advances in VCSELs that have led to recent global deployment of commercial applications including 3D sensing, LIDAR and optical coherent tomography applications. I will also discuss future prospects for advanced applications.
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6

Scappini, F., G. Bruni, G. G. C. Palumbo, and P. Bergman. "HCO+ and HCN observations toward dark clouds and Herbig Ae/Be stars." In The 50th international meeting of physical chemistry: Molecules and grains in space. AIP, 1994. http://dx.doi.org/10.1063/1.46563.

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7

Cox, Erin, Peter Teuben, Robert Harris, Shaye Storm, Lee Mundy, Héctor Arce, Leslie Looney, and Manuel Fernandez-Lopez. "FILAMENTARY STRUCTURE OF SERPENS MAIN AND SERPENS SOUTH SEEN IN N2H+, HCO+, AND HCN." In 71st International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2016. http://dx.doi.org/10.15278/isms.2016.wh12.

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8

Zheng, Yinan, Jimmy Ren, Ryan A. Hlady, Keith D. Robertson, Robert L. Murphy, Lewis R. Roberts, and Lifang Hou. "Abstract LB-235: DNA methylation of individual repetitive elements in HCV infection-induced HCC." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-lb-235.

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9

Dash, Chiranjeev, Mai El Daly, Mohamed Abdel-Hamid, Sherif El Kafrawy, Doa'a Saleh, David S. Goerlitz, Lenka Goldman, and Christopher A. Loffredo. "Abstract 3752: GSTT1 and GSTM1 null genotypes may increase risk of HCV-associated HCC." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3752.

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Powles, Sam, Scott Pallett, Alexandra Finch, Trishan Vaikunthanathan, Fiona Jones, Helen Morgan, Suman Verma, and Matthew Foxton. "P381 Defining HCV cirrhosis by Fibroscan score has a significant impact on HCC surveillance burden." In Abstracts of the BSG Campus, 21–29 January 2021. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2021. http://dx.doi.org/10.1136/gutjnl-2020-bsgcampus.455.

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Звіти організацій з теми "Hcy"

1

Rinke, Helen Mae. HCM Interface. Office of Scientific and Technical Information (OSTI), April 2020. http://dx.doi.org/10.2172/1617344.

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2

Freshley, Megan. Hey Mammal. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1783.

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3

Torres, Ailynn. Más allá de los consensos sobre los cuidados: Notas latinoamericanas. Fundación Carolina, November 2022. http://dx.doi.org/10.33960/ac_20.2022.

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Анотація:
Hoy se cuenta con un acervo importante de conocimiento sobre los cuidados, al cual ha contribuido especialmente América Latina. Sin embargo, hay temas y campos de problemas que continúan siendo preguntas abiertas, escenas de disputas, y terrenos con necesidades de más discusión. Ese es el ángulo principal de este análisis: la identificación de coordenadas que aún no están anudadas, campos de problemas irresueltos, enfoques políticos en tensión, terrenos necesitados de mayor reflexión. El conjunto mostrará filos de la política sobre los cuidados que necesitan ser afrontados y desarrollados, y marcarán una hoja de ruta (incompleta) sobre contenidos que deberían articular políticas y normativas, y vincularse con otros debates estratégicos. Al término se enuncian otros asuntos que requieren ponerse bajo la lupa política.
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Elliott, B., P. Morin, and A. H. Mumin. Hoy Bay hydrothermal alteration. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2015. http://dx.doi.org/10.4095/296613.

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S.A. Cohen and Z. Wang. A Hollow Cathode Magnetron (HCM). Office of Scientific and Technical Information (OSTI), April 1998. http://dx.doi.org/10.2172/3757.

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Smith, I. R., A. Plouffe, R. C. Paulen, M. M. Fenton, and J G Pawlowicz. Surficial geology, Hay River, Alberta. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2005. http://dx.doi.org/10.4095/220605.

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Petrocchi, Rocky, Douglas K. Craig, Jayne-Anne Bond, Donna M. Trott, and Xiao-Ying Yu. Health Code Number (HCN) Development Procedure. Office of Scientific and Technical Information (OSTI), September 2013. http://dx.doi.org/10.2172/1130731.

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Guo, Yili. Spectroscopy and reaction kinetics of HCO. Office of Scientific and Technical Information (OSTI), January 1989. http://dx.doi.org/10.2172/6416970.

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McDonough, M. R., M. A. Cooley, and E. M. Schetselaar. Geology, Hay Camp (74M/11), Alberta. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1994. http://dx.doi.org/10.4095/194138.

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Bonet-Morón, Jaime Alfredo, Gerson Javier Pérez-Valbuena, and Diana Ricciulli-Marin. ¿Hay pereza fiscal territorial en Colombia? Bogotá, Colombia: Banco de la República, December 2017. http://dx.doi.org/10.32468/dtseru.261.

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