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Дисертації з теми "Humoral and cellular immunity"

Автор: Grafiati

Опубліковано: 12 червня 2021

Оновлено: 29 липня 2025

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1

Чорненька, Жанетта Анатоліївна. "CHARACTERISTIC OF INDICATORS OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH DEMODECOSIS." Thesis, Материалы 72-й научно-практической конференции студентов-медиков и молодых ученых с международным участием «Актуальные проблемы современной медицины». Самарканд 11-12 мая 2018 г. С.382, 2018. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/14251.

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2

Vickery, Karen. "The humoral and cellular responses to duck hepatitis B virus." Thesis, The University of Sydney, 1994. https://hdl.handle.net/2123/26913.

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Acute and chronic HBV infection and the resulting liver damage including hepatocellular carcinoma (HCC) are major health problems placing large demands on health resources. In high prevalence areas transmission occurs principally perinatally or in early childhood resulting in a high incidence of chronic life-long carriers. Progress in the study of HBV infection, replication and pathogenesis has depended to a large extent on the development of animal models such as the duck/DHBV model. Although less related to HBV than the mammalian models DHBV was used to demonstrate the unique replication str

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3

Tran, Mai Hue. "Investigations of humoral and cellular immune responses directed against MUCI epithelial mucin in ovarian and breast carcinoma /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17997.pdf.

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4

SILVA, Fabiana Leticia da. "Efeitos da amamentação em camundongos esquistossomóticos na imunidade anti-ovalbumina de descendentes adultos deficientes na produção das citocinas IL-12/IL-23." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/17158.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-06-28T14:37:59Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE_FABIANA_LETICIA_DIGITAL.pdf: 2539644 bytes, checksum: ffb2ea48912cab654c0a8e8bdc397ac2 (MD5)<br>Made available in DSpace on 2016-06-28T14:37:59Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE_FABIANA_LETICIA_DIGITAL.pdf: 2539644 bytes, checksum: ffb2ea48912cab654c0a8e8bdc397ac2 (MD5) Previous issue date: 2014-08-27<br>FACEPE<br>O contato prévi

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5

Santos, Liliane Almeida Carneiro. "Estudo prospectivo sobre a dinâmica da evolução clínica e imunológica da infecção canina por Leishmania (Leishmania) infantum chagasi em área endêmica de leishmaniose visceral no estado do Pará." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-27102016-142051/.

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Leishmaniose visceral canina (LVC) é um dos problemas de saúde pública mais importantes da América Latina, pois geralmente precede a doença humana, a leishmaniose visceral americana (LVA), causada pela Leishmania (L.) infantum chagasi. No presente estudo prospectivo analisou-se durante período de dois anos a prevalência, incidência e dinâmica da evolução clínico-imunológica da infecção canina pela L. (L.) i. chagasi em uma coorte de 316 cães mestiços que vivem em área endêmica de LVA no município de Barcarena, Pará, Amazônia Brasil, pelo uso combinado do teste de imunofluorescência indireta (R

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6

Moreira, Iramirton Figueirêdo. "Imunidade humoral e celular de crianças com desnutrição crônica semi-internas no centro de recuperação e educação nutricional, CRE Maceió/AL - 2008." Universidade Federal de Alagoas, 2009. http://repositorio.ufal.br/handle/riufal/643.

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The World Health Organization defines protein-energy malnutrition as a range of pathological conditions that appear by a deficient supply, transport or use of nutrients by the body s cells causing an essential amino acid deficiency in DNA and RNA synthesis, which can lead to a substantial immune system impairment. The focus of this research was to evaluate humoral and cellular immunity in children suffering from moderate to severe chronic malnutrition. The cross-sectional study was conducted with children 24-59 months old and 29 days, semi-interned at the Nutritional and Education Recovery Cen

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7

SILVA, Bárbara Brooklyn Timóteo Nascimento. "Aspectos imunológicos do caramujo Pomacea lineata (Spix, 1827) sob condições de estivação induzida." Universidade Federal Rural de Pernambuco, 2014. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5039.

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Анотація:

Submitted by (edna.saturno@ufrpe.br) on 2016-07-19T13:52:24Z No. of bitstreams: 1 Barbara Brooklyn Timoteo Nascimento Silva.pdf: 534821 bytes, checksum: 10562bfdf804ec2c27773d76d75cefab (MD5)<br>Made available in DSpace on 2016-07-19T13:52:24Z (GMT). No. of bitstreams: 1 Barbara Brooklyn Timoteo Nascimento Silva.pdf: 534821 bytes, checksum: 10562bfdf804ec2c27773d76d75cefab (MD5) Previous issue date: 2014-02-21<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Pomacea lineata (Spix, 1827) is a pulmonate gastropod that has a large dependence on humidity, Ampullari

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8

Rahman, Bhuiyan Taufiqur. "Humoral and cellular immune responses to Helicobacter pylori in Bangladeshi children and adults that may be related to protection /." Götborg : Department of Microbiology and Immunology, Institute of Biomedicine at Sahlgrenska Academy, University of Gotheburg, 2010. http://hdl.handle.net/2077/21536.

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9

Hein, Héber Eduardo. "Influência da imunidade de matrizes suínas na resposta à vacinação de leitões contra Mycoplasma hyopneumoniae." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/127074.

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A suinocultura está amplamente difundida no Brasil, o quarto maior produtor mundial de carne suína. Seu efetivo está concentrado em maior parte na região Sul, com 48,8% dos suínos. Porém, a intensificação e o confinamento das criações expõem os animais a agentes patogênicos, como o Mycoplasma hyopneumoniae (Mhyo), causador da Pneumonia Enzoótica Suína (PES). A doença é caracterizada pela ocorrência de tosse seca não produtiva e lesões pulmonares de consolidação, denominadas hepatização. A vacinação de leitões é uma importante ferramenta empregada no controle da PES. Contudo, é relatado que a i

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10

Beattie, Lynette. "The role of the spleen in Malaria : Cellular changes that affect the development of immunity." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16195/1/Lynette_Beattie_Thesis.pdf.

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Malaria, caused by the apicomplexan parasite Plasmodium, is a major cause of morbidity and mortality throughout the world. This study has focused on the role of the spleen in the control of the blood stage of infection. Three aspects have been examined specifically: the effect of infection on the architecture of the spleen, the role of the spleen in parasite clearance and the formation of B cell memory. Firstly, the effect of infection on the splenic microarchitecture was examined. An essential component of the splenic architecture is the marginal zone (MZ), an area of the spleen that separa

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11

Beattie, Lynette. "The role of the spleen in Malaria : Cellular changes that affect the development of immunity." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16195/.

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Malaria, caused by the apicomplexan parasite Plasmodium, is a major cause of morbidity and mortality throughout the world. This study has focused on the role of the spleen in the control of the blood stage of infection. Three aspects have been examined specifically: the effect of infection on the architecture of the spleen, the role of the spleen in parasite clearance and the formation of B cell memory. Firstly, the effect of infection on the splenic microarchitecture was examined. An essential component of the splenic architecture is the marginal zone (MZ), an area of the spleen that separa

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12

Silva, Milton Thiago Guerino da. "Avaliação de potencial agente vacinal contra o S.pyogenes em camundongos transgênicos, portadores de genes HLA de classe II humanos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-20122011-155537/.

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A faringite estreptocócica desencadeada pelo Streptococcus pyogenes pode resultar em uma série de doenças humanas e complicações como a febre reumática (FR) em indivíduos predispostos não tratados. A FR é uma doença autoimune que afeta mais de 20 milhões de crianças em países em desenvolvimento. A proteína M presente na membrana do S. pyogenes representa o maior fator de virulência da bactéria, e é objetivo de estudos para o desenvolvimento de uma vacina contra essa patologia. Atualmente mais de 200 tipos de proteínas M foram descritos na literatura e a sua porção Cterminal é conservada entre

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13

Wilson, David. "The mathematical modelling of the cellular dynamics of human infectious diseases." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/37155/8/David%20Wilson%20Thesis.pdf.

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14

Shidani, Babak. "Effet de la cyclosporine a sur le systeme immunitaire de la souris." Paris 7, 1987. http://www.theses.fr/1987PA077159.

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15

Reidel, Ivana. "Análisis de nuevos vehículos y adyuvantes para inmunización con antígenos de Staphylococcus aureus utilizando diferentes modelos experimentales." Thesis, Poitiers, 2020. http://www.theses.fr/2020POIT1803.

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Les infections à Staphylococcus aureus représentent un enjeu majeur en santé humaine et en médecine vétérinaire. L’usage excessif d’antibiotiques pour traiter ces infections a conduit à l’émergence de souches multirésistantes et incite à développer d’autres méthodes préventives comme la vaccination. A ce jour aucun vaccin n’est approuvé en médecine humaine et seulement 2 vaccins, peu satisfaisants, sont utilisés dans le contrôle de la mastite bovine. Il est donc nécessaire de développer de nouvelles formulations vaccinales plus efficaces.L’objectif de ce travail de thèse est de tester de nouve

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16

Quiniou, Debrie Marie-Christine. "Immunité anti-ilots chez des diabétiques insulino-dépendants de type 1." Paris 6, 1986. http://www.theses.fr/1986PA066085.

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La destruction sélective des cellules bêta des ilots de Langerhans pourrait être due à une réaction immunitaire dirigée contre elles. Etude de la phase effectrice de la réponse auto-immune c'est-à-dire l'immunité cellulaire, l'immunité humorale complément dépendante, la cytotoxicité cellulaire dépendante d'anticorps chez les diabétiques de type 1. L'évolution de ces paramètres a été étudiée en fonction de la durée clinique de la maladie et de la présence ou de l'absence de manifestations auto-immunes extra-pancréatiques.

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17

Meissonnier, Guylaine. "Effets toxiques de l'aflatoxine b1 et de la toxine t-2 sur les systèmes de défenses métaboliques et immunitaires chez le porc, évaluation des effets protecteurs de glucomannanes." Toulouse 3, 2007. http://www.theses.fr/2007TOU30153.

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L'aflatoxine B1 (AFB1) et la toxine T-2 sont des mycotoxines, métabolites secondaires de micromycètes qui peuvent contaminer les denrées alimentaires notamment les céréales. Les objectifs de nos travaux ont été de déterminer chez le porc, une espèce cible et sensible aux mycotoxines, les effets toxiques de l'AFB1 et de la toxine T-2 sur deux systèmes de défense, les enzymes de biotransformation et l'immunité. De plus, nous avons évalué in vivo l'effet protecteur d'un potentiel liant de toxine. Chez le porc, l'exposition à l'AFB1 aux doses testées n'a pas provoqué de manifestations cliniques ma

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18

Sukkar, Dani. "Role of Nosema cerenae and pesticides on the decline of bees : Studies using a multifactorial approach : “Tipping the scale of honeybee immune responses - The effect of pesticides on immune-stimulation mimicking Nosema spp.”." Electronic Thesis or Diss., Université de Lorraine, 2023. http://www.theses.fr/2023LORR0086.

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Les abeilles sont confrontées à la menace mondiale du syndrome d'effondrement des colonies (CCD), entraînant des décès de colonies et une diminution de leur nombre, affectant leur contribution environnementale et agronomique dans la pollinisation des plantes et des cultures commerciales, en plus de la production de miel. L'exposition aux pesticides peut être l'une des principales causes conduisant au CCD en affaiblissant le système immunitaire des abeilles et en altérant leurs réponses immunitaires. Les maladies de la nosémose causées par Nosema spp. peuvent avoir une contribution significativ

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19

Pelletier, Lucette. "Mecanismes cellulaires impliques dans l4 autoimmunite induite par hgcl : :(2) chez le rat." Paris 6, 1987. http://www.theses.fr/1987PA066573.

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20

Florentin, Irène. "Caracterisation fonctionnelle comparative de substances immunomodulatrices." Paris 6, 1987. http://www.theses.fr/1987PA066374.

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21

Gougerot-Pocidalo, Marie-Anne. "Processus oxydants et reponses immunitaires : mecanismes biochimiques et cellulaires." Paris 7, 1988. http://www.theses.fr/1988PA077063.

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22

Schmitt, Christian. "Etude de clones de lymphocytes t humains specifiques de l'anatoxine tetanique." Paris 7, 1987. http://www.theses.fr/1987PA077003.

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23

Nohr, Carl William. "Humoral immunity in surgical patients." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75969.

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Humoral immune function was studied in surgical patients. The antibody response to vaccination with a protein antigen, tetanus toxoid (TT), was reduced among all patients, especially those with reduced delayed type hypersensitivity (DTH) and increased degree of physiological derangement. The antibody response to a polysaccharide antigen, pneumococcal polysaccharide (PPS), was normal. In trauma patients, the antibody response to TT was normal. The in vitro production of specific and total immunoglobulin (Ig) by blood mononuclear cells was studied. Patients that failed to produce a serum antibod

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24

Cassis, Linda 1977. "Role of progranulin in humoral immunity." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/398398.

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Human spleen is continually exposed to blood-borne antigens derived from autologous apoptotic cells and commensal bacteria. This chronic stimulation of the marginal zone (MZ) results in the generation of a steady-state antibody response that occurs under non-inflammatory conditions. Immunoregulatory signals, still poorly understood, are required to avoid continuous inflammation. Our group identified a population of splenic neutrophils called B cell-helper neutrophils (NBH cells) that contribute to the induction of steady-state antibody responses in the MZ1. NBH cells express B cell-activat

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25

Rydyznski, Carolyn E. "Natural Killer Cell Regulation of Humoral Immunity." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535377157934852.

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26

Fayette, Jérôme. "Effet des cellules dendritiques humaines générées in vitro sur la réponse immunitaire humorale." Lyon 1, 1998. http://www.theses.fr/1998LYO1T259.

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27

Berkeley, Robert Anthony. "Immune cell carriers and humoral immunity in oncolytic virotherapy." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/20532/.

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Oncolytic viruses (OV) represent an emerging modality in cancer therapy. Antiviral immunity is currently viewed as a barrier to systemic OV efficacy. Approaches have been taken to promote OV activity by attenuating virus-neutralising antibodies (NAb). However, the presence of NAb does not prevent intravenously administered OV, such as reovirus, reaching tumours in patients. Recent evidence suggests that NAb may in fact support virotherapy in mice by facilitating reovirus carriage upon circulating immune cells, principally monocytes. In this thesis, the applicability of these observations to th

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28

Willems, Kristen N. "Regulation of Humoral Immunity by Pim Kinases: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/567.

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Pim (Provirus Integration site for Moloney murine leukemia virus) kinases are a family of three serine/threonine kinases involved in cell cycle, survival and metabolism. These kinases were first identified in malignant cells and are most often associated with their role in cancer. Their role in immunity and lymphocytes is less well known. To date, it has been shown that Pim 1 and/or Pim 2 are important for T lymphocyte survival and activation when the Akt signaling pathway is inhibited by rapamycin. In addition, our laboratory has shown that Pim 2 is critical for BLyS-mediated naive B lymphocy

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29

Smith, Karen. "Cellular and humoral mechanisms of allergic disease." Thesis, University of Brighton, 2012. https://research.brighton.ac.uk/en/studentTheses/57df8daa-8006-4dff-8d44-ba39572913aa.

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CD 154 is a T cell activation marker, transiently expressed following ligation of the T cell receptor, therefore providing direct access to an antigen-specific T cell population. Using peripheral blood samples taken from allergic individuals and healthy non-atopic controls, this project identified and phenotyped CD 154 + T helper cells following ex vivo stimulation with native allergen extracts (birch pollen, cat dander, grass pollen). Peripheral blood mononuclear cells were stimulated with allergen extract for 16 hours in the presence of Brefeldin A. Responding CD 154 + T cells were identifie

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30

Rembert, Audrey. "Les vaccins antivarioliques : pathogénicité-innocuité, immunogénicité humorale et cellulaire, protection." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20707.

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La variole, éradiquée en 1980, a représenté l’un des plus grands fléaux. Le risque de réémergence du virus de la variole rend nécessaire l’évaluation de nouveaux vaccins. Le but de notre étude était d’étudier les facteurs immunitaires essentiels à la résistance naturelle contre les orthopoxvirus et d’évaluer de nouveaux vaccins antivarioliques. La caractérisation du modèle d’infection souris/cowpox virus nous a permis de constater que la protection de la souris était due à l’ensemble des réponses immunitaires spécifiques. Un vaccin de 2ème génération (2G) et trois souches de vaccines non répli

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31

Shimokata, Kaoru. "Cytokines and Local Cellular Immunity." 名古屋大学医学部, 1997. http://hdl.handle.net/2237/6185.

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32

Wendling, Daniel. "Aspects immunologiques et systemiques des spondylarthropathies." Besançon, 1991. http://www.theses.fr/1991BESA3703.

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33

Bruns, Nicholas Joseph. "Humoral and cell-mediated immunity in vitamin A-deficient lambs." Diss., Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/53919.

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Antigen-specific and polyclonal serum immunoglobulin G (IgG) concentrations were measured in control (Con), vitamin A-deficient (A-def), and vitamin A-repleted (A-rep) lambs. In Trial, I ewe lambs were injected with primary and secondary antigenic challenges of ovalbumin (1mg) and lysozyme (.1mg). The A-def lambs were then repleted with vitamin A and all lambs were injected with primary and secondary antigenic challenges of human gamma globulin (HGG) (.1mg). In Trial II Con and A-def wether lambs were given primary and secondary antigenic challenges of ovalbumin (20μg). Half of the A-def lambs

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34

Sallam, Jamal A. "Intestinal humoral immunity in man : IgA and anti-salmonella antibodies." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20766.

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Studies of gut immunity must be carried out on intestinal fluid and jejunal biopsies. Recent work from Edinburgh has shown that the use of Whole Gut Lavage (WGL) technique is a non-invasive, direct and reliable method of obtaining intestinal fluids. My thesis describes the use of WGL technique in a variety of studies on gastro-intestinal mucosal immunity. The effect of the newly licensed oral live typhoid vaccine Ty21a on gut immunity was investigated in a group of 22 healthy British volunteers. Later on, the intestinal immune responses to naturally acquired <I>Salmonella</I> infection were in

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35

Casas, Rosaura. "Transfer of humoral immunity from the mother to her off-spring /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med692s.pdf.

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36

Wuttge, Dirk Marcus. "Cellular immunity and inflammation in atherosclerosis /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-051-2/.

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37

Lucin, Kurt M. "Mechanisms of impaired humoral immunity after high thoracic spinal cord injury." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186411177.

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38

Yassine, Daadaa. "Network Decontamination with Temporal Immunity." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20633.

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Network decontamination is a well known mobile agent problem with many applications. We assume that all nodes of a network are contaminated (e.g., by a virus) and a set of agents is deployed to decontaminate them. An agent passing by a node decontaminates it, however a decontaminated node can be recontaminated if any of its neighbours is contaminated. In the vast literature a variety of models are considered and different assumptions are made on the power of the agents. In this thesis we study variation of the decontamination problem in mesh and tori topologies, under the assumption that when

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39

Makedonas, George. "Cellular immunity among HIV exposed, uninfected individuals." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111828.

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Two models of HIV infection have been studied extensively with the goal of identifying immune correlate(s) of protection against HIV: (1) the simian immunodeficiency virus (SIV) infection of rhesus macaque monkeys and (2) individuals with repeated exposure to HIV who remain uninfected by the virus (EUs). Both paradigms suggest that T cell-mediated immunity plays an important role in controlling HIV replication. Evidence from the SIV/macaque system, however, predicts that HIV vaccines aimed at eliciting T cell responses will fail to induce sterilizing immunity against HIV. The aim of the work p

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Tye, Gee Jun. "Combined adjuvant for stimulation of cellular immunity." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/combined-adjuvant-for-stimulation-of-cellular-immunity(b1be07ae-b8d4-40a8-9258-bc3e3413df9d).html.

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Vaccination has important clinical potential in the immunotherapy of both infectious disease and cancer. The central aim of the studies reported in this thesis has been the development of vaccination strategies that will be effective for therapeutic applications in cancer. Using ovalbumin antigen in a mouse model, we have examined a combination of recently developed adjuvants referred to as CASAC (combined adjuvants for synergistic stimulation of cellular immunity) to optimise the efficacy of vaccination induced T cell mediated immunity. These studies have examined the effect of repeated round

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41

Patel, Mihil. "Regulation of cellular immunity by human cytomegalovirus." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/114496/.

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The success of HCMV as a lifelong pathogen is attributed at least in part to the broad range of encoded immune evasion molecules that inhibit the host cellular immune response. Indeed, HCMV has become a paradigm for immune evasion, the study of which has revealed a number of basic immunological processes. To screen for novel immune evasion genes, HCMV-specific CD8+ T-cell lines were grown from seropositive donors and used against a series of block deletion viruses, each missing a region of genes non-essential for replication in vitro. UL13-UL20 was flagged as important for inhibition of CD8+ T

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Abuhammash, E. V. "Transfer actor as mediator of cellular immunity." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32144.

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Transfer factor (s) - are small molecules, that transfer the ability to recognize pathogens (bacterial or viral) cells of the immune system, never exposed to this pathogen. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32144

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Titanji, Kehmia. "Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-728-6/.

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Ng, D. H. L. "Loss and recovery of humoral immunity to influenza virus following malaria infection." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1349451/.

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The mechanisms of maintenance of humoral immunity to infectious pathogens, particularly the contributions of memory B cells and long-lived plasma cells in maintaining specific serum antibody titres, are not well understood. Furthermore, it is not clear whether sequential heterologous humoral immune responses and disease pathology can result in the dysregulation and loss of previously acquired antibody-mediated immune responses to unrelated antigens. Here, depletion of memory B cells using anti-hCD20 monoclonal antibodies in hCD20 transgenic mice was used to dissect the role of memory B cells a

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Lownik, Joseph C. "The Role of ADAM10 and ADAM17 in Humoral and Type 2 Immunity." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5680.

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The proper regulation of inducible costimulator (ICOS) and its ligand (ICOSL) have been shown to be essential for maintaining immune homeostasis. Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in aberrant antibody production resembling lupus. How ICOSL is regulated in response to ICOS interaction is still unclear. We demonstrate that ADAM10 is the primary physiological sheddase of ICOSL in both mouse and human. Using an in vivo system in which ADAM10 is deleted only on B cells (ADAM10B-/-), elevated levels of ICOSL were seen. This increase is a

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Brock, Robert W. "The initiation of remote hepatic injury, humoral and cellular mediators." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58201.pdf.

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Atta, Mustafa S. "Investigation of the humoral and cellular features of autoimmune diseases." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281586.

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48

Blevins, Sarah. "Characterizing Compensatory Effects of Silymarin on Gossypol Toxicosis in Lines of Chickens Divergently Selected for Humoral Immune Response." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/34609.

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Feed costs are approximately 70% of total production cost for poultry producers. Poultry diets in the United States generally consist of 2 grains: corn and soybean meal. In recent years, the cost of these grains has dramatically increased. Due to these price increases, producers seek alternative feeds that provide adequate nutrition, and are also more affordable than â traditionalâ grains. Cottonseed meal is one alternative that is both affordable and an excellent source of crude protein. However, cottonseed meal contains gossypol, a pigment toxic to chickens. This study had two main object

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White, Sarah Elise, and Sarah Elise White. "Can current methods of immune rejuvenation improve humoral immunity against a viral infection?" Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626801.

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The process of aging impacts immune defense against infection. This is attributed to immunosenescence, which is defined as a gradual decline in the function of the immune system. This decline is widespread, affecting both cell-mediated and humoral immunity, which both play an integral role in pathogen recognition and elimination. Lymphoid organs are known to undergo structural and functional changes with age and understanding these changes and how they can be prevented or reversed is critical if we are to improve immunity in older adults. We studied two immune rejuvenation methods: the a

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Wong, Garret Drew. "Human humoral immunity to respiratory syncytial virus, correlates of disease severity and protection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/MQ32975.pdf.

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