Готові списки джерел за темами / Hydrogel wound dressings

Добірка наукової літератури з теми "Hydrogel wound dressings"

Автор: Grafiati
Опубліковано: 13 вересня 2021
Оновлено: 25 квітня 2022

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Статті в журналах з теми "Hydrogel wound dressings":

1

Su, Jingjing, Jiankang Li, Jiaheng Liang, Kun Zhang, and Jingan Li. "Hydrogel Preparation Methods and Biomaterials for Wound Dressing." Life 11, no. 10 (September 27, 2021): 1016. http://dx.doi.org/10.3390/life11101016.

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Wounds have become one of the causes of death worldwide. The metabolic disorder of the wound microenvironment can lead to a series of serious symptoms, especially chronic wounds that bring great pain to patients, and there is currently no effective and widely used wound dressing. Therefore, it is important to develop new multifunctional wound dressings. Hydrogel is an ideal dressing candidate because of its 3D structure, good permeability, excellent biocompatibility, and ability to provide a moist environment for wound repair, which overcomes the shortcomings of traditional dressings. This article first briefly introduces the skin wound healing process, then the preparation methods of hydrogel dressings and the characteristics of hydrogel wound dressings made of natural biomaterials and synthetic materials are introduced. Finally, the development prospects and challenges of hydrogel wound dressings are discussed.
2

Brumberg, Valentin, Tatiana Astrelina, Tatiana Malivanova, and Alexander Samoilov. "Modern Wound Dressings: Hydrogel Dressings." Biomedicines 9, no. 9 (September 16, 2021): 1235. http://dx.doi.org/10.3390/biomedicines9091235.

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Chronic wounds do not progress through the wound healing process in a timely manner and are considered a burden for healthcare system; they are also the most common reason for decrease in patient quality of life. Traditional wound dressings e.g., bandages and gauzes, although highly absorbent and effective for dry to mild, exudating wounds, require regular application, which therefore can cause pain upon dressing change. In addition, they have poor adhesional properties and cannot provide enough drainage for the wound. In this regard, the normalization of the healing process in chronic wounds is an extremely urgent task of public health and requires the creation and implementation of affordable dressings for patients with chronic wounds. Modern wound dressings (WDs) are aimed to solve these issues. At the same time, hydrogels, unlike other types of modern WDs (foam, films, hydrocolloids), have positive degradation properties that makes them the perfect choice in applications where a targeted delivery of bioactive substances to the wound is required. This mini review is focused on different types of traditional and modern WDs with an emphasis on hydrogels. Advantages and disadvantages of traditional and modern WDs as well as their applicability to different chronic wounds are elucidated. Furthermore, an effectiveness comparison between hydrogel WDs and the some of the frequently used biotechnologies in the field of regenerative medicine (adipose-derived mesenchymal stem cells (ADMSCs), mesenchymal stem cells, conditioned media, platelet-rich plasma (PRP)) is provided.
3

Liu, Yangyang, Shurui Song, Shuangyong Liu, Xiaoyan Zhu, and Peige Wang. "Application of Nanomaterial in Hydrogels Related to Wound Healing." Journal of Nanomaterials 2022 (January 4, 2022): 1–11. http://dx.doi.org/10.1155/2022/4656037.

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Traditional dressings used for wound repair, such as gauze, have shortcomings; for example, they cannot provide a suitable microenvironment for wound recovery. Therefore, it is necessary to find a better dressing to overcome shortcomings. Hydrogel provides a suitable wet environment, has good biocompatibility, and has a strong swelling rate to absorb exudate. Nanomaterial in hydrogels has been used to improve their performance and overcome the shortcomings of current hydrogel dressings. Hydrogel dressing can also be loaded with nanodrug particles to exert a better therapeutic effect than conventional drugs and to make the dressing more practical. This article reviews the application of nanotechnology in hydrogels related to wound healing and discusses the application prospects of nanohydrogels. After searching for hydrogel articles related to wound healing, we found that nanomaterial can not only enhance the mechanical strength, antibacterial properties, and adhesion of hydrogels but also achieve sustained drug release. From the perspective of clinical application, these characteristics are significant for wound healing. The combination of nanomaterial and hydrogel is an ideal dressing with broad application prospects for wound healing in the future.
4

Kuznetsova, T. A., N. N. Besednova, V. V. Usov, and B. G. Andryukov. "Biocompatible and biodegradable wound dressings on the basis of seaweed polysaccharides (review of literature)." Grekov's Bulletin of Surgery 179, no. 4 (November 8, 2020): 109–15. http://dx.doi.org/10.24884/0042-4625-2020-179-4-109-115.

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The review presents the characteristics of modern biocompatible and biodegradable wound dressings on the basis of seaweed polysaccharides (carrageenans of red algae, fucoidans and alginates of brown algae, ulvans of green algae) and notes the key physicochemical and biological properties that are important for constructing wounds dressings. There are information on various types of wound dressings and results of experimental and clinical tests of dressings in the treatment of wounds of various origins. Particular attention is paid to hydrogel dressings, since hydrogels meet the basic requirements for an ideal wound dressing, and many marine polysaccharides are able to form hydrogels.
5

Francesko, Antonio, Petya Petkova, and Tzanko Tzanov. "Hydrogel Dressings for Advanced Wound Management." Current Medicinal Chemistry 25, no. 41 (January 31, 2019): 5782–97. http://dx.doi.org/10.2174/0929867324666170920161246.

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Background: Composed in a large extent of water and due to their nonadhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the patient. Hydrogels’ exploitation is constantly increasing after evidences of their even broader therapeutic potential due to resemblance to dermal tissue and ability to induce partial skin regeneration. The innovation in advanced wound care is further directed to the development of so-called active dressings, where hydrogels are combined with components that enhance the primary purpose of providing a beneficial environment for wound healing. Objective: The objective of this review is to concisely describe the relevance of hydrogel dressings as platforms for delivery of active molecules for improved management of difficult- to-treat wounds. The emphasis is on the most recent advances in development of stimuli- responsive hydrogels, which allow for control over wound healing efficiency in response to different external modalities. Novel strategies for monitoring of the wound status and healing progress based on incorporation of sensor molecules into the hydrogel platforms are also discussed.
6

Tsegay, Filmon, Mohamed Elsherif, and Haider Butt. "Smart 3D Printed Hydrogel Skin Wound Bandages: A Review." Polymers 14, no. 5 (March 3, 2022): 1012. http://dx.doi.org/10.3390/polym14051012.

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Wounds are a major health concern affecting the lives of millions of people. Some wounds may pass a threshold diameter to become unrecoverable by themselves. These wounds become chronic and may even lead to mortality. Recently, 3D printing technology, in association with biocompatible hydrogels, has emerged as a promising platform for developing smart wound dressings, overcoming several challenges. 3D printed wound dressings can be loaded with a variety of items, such as antibiotics, antibacterial nanoparticles, and other drugs that can accelerate wound healing rate. 3D printing is computerized, allowing each level of the printed part to be fully controlled in situ to produce the dressings desired. In this review, recent developments in hydrogel-based wound dressings made using 3D printing are covered. The most common biosensors integrated with 3D printed hydrogels for wound dressing applications are comprehensively discussed. Fundamental challenges for 3D printing and future prospects are highlighted. Additionally, some related nanomaterial-based hydrogels are recommended for future consideration.
7

Dovison, Russell, and Anne-Maree Keenan. "Wound Healing and Infection in Nail Matrix Phenolization Wounds." Journal of the American Podiatric Medical Association 91, no. 5 (May 1, 2001): 230–33. http://dx.doi.org/10.7547/87507315-91-5-230.

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After nail matrix ablation using phenolization, a medicated wound dressing (10% povidone iodine), an amorphous hydrogel dressing (Intrasite Gel), and a control dressing (paraffin gauze) were evaluated. Forty-two participants, randomly divided into three dressing groups, were evaluated. Healing time did not differ between the 10% povidone iodine (33 days), amorphous hydrogel (33 days), and the control dressing (34 days). For all groups, the clinical infection rate was lower than in previous studies, and there was no clinical difference between groups (one infection in the povidone iodine and control groups; none in the amorphous hydrogel group). However, in the amorphous hydrogel group, other complications, such as hypergranulation, were more likely. This investigation indicated that medicated or hydrogel dressings did not enhance the rate of healing or decrease infection rates. (J Am Podiatr Med Assoc 91(5): 230-233, 2001)
8

Beam, Joel W. "Occlusive Dressings and the Healing of Standardized Abrasions." Journal of Athletic Training 43, no. 6 (November 1, 2008): 600–607. http://dx.doi.org/10.4085/1062-6050-43.6.600.

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Abstract Context: Acute skin trauma during sport participation, resulting in partial-thickness abrasions, is common. The limited investigations focusing on the acute wound environment and dressing techniques and the subsequent lack of evidence-based standards complicate clinical wound care decisions. Objective: To examine the effects of occlusive dressings on healing of standardized, partial-thickness abrasions. Design: Controlled, counterbalanced, repeated-measures design. Setting: University laboratory. Patients or Other Participants: Sixteen healthy women (n = 10) and men (n = 6). Intervention(s): Four standardized, partial-thickness abrasions were inflicted. Film, hydrogel, and hydrocolloid occlusive dressings and no dressing (control) were applied. Participants returned on postwound days 1, 3, 5, 7, 10, and 14 for digital imaging. Wound healing time was measured by change in wound contraction (cm2) and change in wound color (chromatic red) and luminance in red, green, and blue color values. Main Outcome Measure(s): Wound contraction, color (chromatic red), and luminance. Results: A day-by-dressing interaction was found for wound contraction, color, and luminance. Post hoc testing indicated that the film and hydrocolloid dressings produced greater wound contraction than the hydrogel and no dressing on days 7 and 10. Film, hydrogel, and hydrocolloid dressings also resulted in greater wound contraction than the control on day 14. Hydrocolloid dressings produced smaller measures of color and greater measures of luminance than no dressing on day 7. Film, hydrogel, and hydrocolloid dressings also resulted in smaller measures of color and greater measures of luminance compared with no dressing on days 10 and 14. Conclusions: When compared with the control (no dressing), the film, hydrogel, and hydrocolloid occlusive dressings were associated with a faster healing rate of partial-thickness abrasions across time measured by wound contraction, color, and luminance. Overall, these data indicate that occlusive dressings were more effective in healing than no dressing was.
9

Surowiecka, Agnieszka, Jerzy Strużyna, Aleksandra Winiarska, and Tomasz Korzeniowski. "Hydrogels in Burn Wound Management—A Review." Gels 8, no. 2 (February 15, 2022): 122. http://dx.doi.org/10.3390/gels8020122.

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Inert hydrogels are of a great importance in burn first aid. Hydrogel dressings may be an alternative to cooling burn wounds with streaming water, especially in cases of mass casualty events, lack of clean water, hypothermia, or large extent of burns. Hydrogels that contain mostly water evacuate the heat cumulating in the skin by evaporation. They not only cool the burn wound, but also reduce pain and protect the wound area from contamination and further injuries. Hydrogels are ideally used during the first hours after injury, but as they do not have antimicrobial properties per se, they might not prevent wound infection. The hydrogel matrix enables incorporating active substances into the dressing. The active forms may contain ammonium salts, nanocrystal silver, zinc, growth factor, cytokines, or cells, as well as natural agents, such as honey or herbs. Active dressings may have antimicrobial activity or stimulate wound healing. Numerous experiments on animal models proved their safety and efficiency. Hydrogels are a new dressing type that are still in development.
10

Ahmad, Faheem, Bushra Mushtaq, Faaz Ahmed Butt, Muhammad Sohail Zafar, Sheraz Ahmad, Ali Afzal, Yasir Nawab, Abher Rasheed, and Zeynep Ulker. "Synthesis and Characterization of Nonwoven Cotton-Reinforced Cellulose Hydrogel for Wound Dressings." Polymers 13, no. 23 (November 25, 2021): 4098. http://dx.doi.org/10.3390/polym13234098.

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Hydrogels wound dressings have enormous advantages due to their ability to absorb high wound exudate, capacity to load drugs, and provide quick pain relief. The use of hydrogels as wound dressings in their original form is a considerable challenge, as these are difficult to apply on wounds without support. Therefore, the incorporation of polymeric hydrogels with a certain substrate is an emerging field of interest. The present study fabricated cellulose hydrogel using the sol–gel technique and reinforced it with nonwoven cotton for sustainable wound dressing application. The nonwoven cotton was immersed inside the prepared solution of cellulose and heated at 50 °C for 2 h to form cellulose hydrogel–nonwoven cotton composites and characterized for a range of properties. In addition, the prepared hydrogel composite was also loaded with titania particles to attain antibacterial properties. The Fourier transform infrared spectroscopy and scanning electron microscopy confirmed the formation of cellulose hydrogel layers inside the nonwoven cotton structure. The fabricated composite hydrogels showed good moisture management and air permeability, which are essential for comfortable wound healing. The wound exudate testing revealed that the fluid absorptive capacity of cellulose hydrogel nonwoven cotton composite was improved significantly in comparison to pure nonwoven cotton. The results reveal the successful hydrogel formation, having excellent absorbing, antimicrobial, and sustainable properties.
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Статті в журналах Дисертації

Дисертації з теми "Hydrogel wound dressings":

1

Köhler, Julia [Verfasser], and Achim [Akademischer Betreuer] Göpferich. "Hydrogel Wound Dressings for the Bioactive Treatment of Acute and Chronic Wounds / Julia Köhler ; Betreuer: Achim Göpferich." Regensburg : Universitätsbibliothek Regensburg, 2017. http://d-nb.info/1162339551/34.

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2

Goutay, Natacha. "Adhésion stable en milieu humide de pansements dits "hydrocolloïdes"." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066019/document.

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Les pansements dits " hydrocolloïdes " sont très couramment utilisés dans le traitement des plaies à forte exsudation. Ils permettent de réguler l'hygrométrie au sein d'une plaie tout en évitant une accumulation d'eau susceptible d'entrainer la prolifération de bactéries entre le pansement et la peau. Deux propriétés antagonistes apparaissent alors nécessaires : une fonction d'adhésion pour assurer le maintien du pansement sur la peau, et de fortes propriétés d'absorption et de perméabilité à l'eau pour réguler l'humidité et favoriser la cicatrisation de la plaie. Pour satisfaire ces deux fonctions, des systèmes hétérogènes sont utilisés : l’adhésion est apportée par une matrice adhésive hydrophobe, composée d’un élastomère modifié par un plastifiant et des résines tackifiantes, la régulation de l’humidité est assurée par de fines particules hydrophiles sèches de carboxymethylcellulose (CMC), dispersées dans la matrice adhésive. Un enjeu majeur de ces pansements est le maintien de l’adhésion cutanée dans le temps. Or une perte de l’adhésion est souvent observée après un long contact avec l’eau. Ces travaux de thèse visent à mieux comprendre l’origine de cette perte d’adhésion, à travers l’étude des propriétés mécaniques de la matrice hydrophobe, de ses interactions avec les particules hydrophiles et des mécanismes de transport d’eau. La substitution de la CMC par des particules d’hydrogels synthétisés au laboratoire a permis l’étude plus systématique de l’effet des propriétés physico-chimiques de la phase hydrophile sur l’absorption, la perméabilité et l’adhésion des pansements hydrocolloïdes ainsi mis en œuvre
Hydrocolloid wound dressings are commonly used for the care of highly exuding wounds. They allow to control the wound moisture, while avoiding the water accumulation which could lead to bacterial proliferation between the dressing and the skin. Two antagonist properties appear to be required: an adhesive function to maintain the dressing on the skin, and high water absorption and permeability to control the humidity level and promote healing. To achieve both properties, heterogeneous systems are used : the adhesion is ensured by an hydrophobic adhesive matrix, made of an elastomer modified by plasticizers and tackifying resins, the regulation of the humidity relies on fine dry hydrophilic particles, made of carboxymethylcellulose (CMC), dispersed within the matrix. A major issue of these wound dressings is to maintain a long term skin adhesion. However a loss of adhesion is often observed after a long contact with water. This PhD work aims at a better understanding the origin of this loss of adhesion through the study of the hydrophobic matrix mechanical properties, its interactions with the hydrophilic particles and water transport. Replacing the CMC by tailor-made hydrogel particles allowed to a systematic study of the impact of the physico-chemical properties of the hydrophilic phase on the absorption, the permeability and the adhesion of the hydrocolloid-based adhesives
3

Balášová, Patricie. "Příprava a charakterizace moderních krytů ran." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449701.

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This diploma thesis is focused on the study of bioactive wound dressings. During the thesis, hydrogel, lyophilized and nanofiber wound dressings were prepared. Hydrogel and lyophilized wound dressings were prepared on basis of two polysaccharides – alginate and chitosan. Nanofiber wound dressings were prepared by spinning polyhydroxybutyrate. All prepared wound dressings were enriched with bioactive substances, which represented analgesics (ibuprofen), antibiotics (ampicillin) and enzymes (collagenase). Into hydrogel and lyophilized wound dressings were all the mentioned active substances incorporated, whereas nanofiber wound dressings were only with ibuprofen and ampicillin prepared. The theoretical part deals with the anatomy and function of human skin. There was explained the process of wound healing and also there were introduced available modern wound dressings. The next chapter of the theoretical part deals with materials for preparing wound dressings (alginate, chitosan, polyhydroxybutyrate) and with active substances, which were used during the experimental part of this thesis. In the theoretical part, the methods of preparation of nanofiber wound dressings and also the methods of cytotoxicity testing used in this work were presented. The first part of the experimental part of this thesis was focused on preparing already mentioned wound dressings. Then, their morphological changes over time and also the gradual release of incorporated active substances into the model environment were monitored. The gradual release of ampicillin was monitored not only spectrophotometrically, but also by ultra-high-performance chromatography. In wound dressings, in which collagenase was incorporated, was also the final proteolytic activity of this enzyme monitored. The effect of the active substances was observed on three selected microorganisms: Escherichia coli, Staphylococcus epidermidis and Candida glabrata. The cytotoxic effect of the active substances on the human keratinocyte cell line was monitored by MTT test and LDH test. A test for monitoring the rate of wound healing – a scratch test – was also performed.
4

Bibi, Nurguse. "Elastase responsive hydrogel dressing for chronic wounds." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/elastase-responsive-hydrogel-dressing-for-chronic-wounds(f2a1f950-d38d-4cb2-8b8e-3c1e10ef7910).html.

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Chronic wounds are a major financial and clinical burden causing the deaths of millions per year. Over expression of elastase is well documented as the main culprit that delays the normal wound repair process within chronic wounds. The aim of this thesis is to design a responsive chronic wound dressing based on the hydrogel polymer, PEGA (polyethylene glycol acrylamide) in the form of particles to mop-up excess elastase by exploiting polymer collapse in response to elastase hydrolytic activity within sample fluids mimicking the environment of chronic wounds. PEGA particles were functionalised with enzyme cleavable peptides (ECPs) containing charged residues. Upon cleavage the charge balance changes, causing polymer swelling and consequent elastase entrapment. The pH range of chronic wounds is reported in the range of 5.45 - 8.65. Due to its pI which is around 8.3, within this range elastase exist both in its cationic and anionic forms. To accommodate a hydrogel dressing that could selectively entrap excess elastase both in its cationic and anionic, oppositely charged ECPs were designed. In its cationic form, elastase was found to have a high preference of cleaving ECPs and penetrating into PEGA particles bearing negative charges. In contrast, in its anionic form the opposite effect was observed, wherein elastase preferred to cleave ECPs and penetrate PEGA particles bearing positive charges. The diffusion, accessibility and entrapment of elastase into functionalised PEGA particles was explored using various fluorescence microscopy techniques. Removal of the charged residue by elastase showed a reduction in particle swelling causing the pores of PEGA particles to become restricted. In this manner, cleaved PEGA particles prevented the accessibility of molecules with a molecular weight as low as 20 kDa into the cleaved PEGA particles. Since elastase has a molecular weight of 25.9 kDa the collapsing of the pores within PEGA particles entrapped elastase inside the interior of cleaved PEGA particles. In its cationic form (at pH 7.4) elastase was found to penetrate and become trapped more into both negative and positive PEGA particles compared to neutral particles. The negative particles were shown to trapped cationic elastase within 2 minutes compared to the positive particles. In contrast, the neutral particles failed to retain and encapsulate elastase as the fluorescence inside the neutral particles was found to decrease. Coinciding with these observations, after sample fluids containing elastase were treated with functionalised PEGA particles, the residual elastase activity in sample fluids was reduced more by the charged PEGA particles compared to neutral particles. The cell culture studies demonstrated that the elastase activity observed in human dermal fibroblasts (HDF) was also reduced more by the charged particles compared to the neutral particles. However, the positive particles were found to significantly reduced HDF-elastase activity compared to both the negative and neutral PEGA particles. Overall, this thesis exemplifies that on the basis of charge selective cleaving of ECPs coupled to PEGA particles can be exploited to selectively remove excess proteases such as elastase from sample fluids mimicking the environment of chronic wounds.
5

Dzurická, Lucia. "Příprava a charakterizace krytů ran." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-414181.

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The diploma thesis if focused on the study of bioactive hydrogél and nanofiber wound dressings composed of natural biopolymers, which were functionalized by active compounds in the form of analgesic, antibiotics and enzymes. Hydrogél wound dressings were constituted from alginate and chitosan and nanofibers were created from polyhydroxybutyrate. The following 7 active compounds were selected to be added to the wound dressings: ampicillin, streptomycin, ibuprofen, papain, bromelain, collagenase and trypsin. In the theoretical part the structure of the skin and types of wound injuries were described. This part also talks about types of wound dressing and their applications, as well as treatment of skin wounds using enzymes and compounds with analgesic and antimicrobial properties. In addition, this section describes safety assays, in particular cytotoxicity assays on human cells. At the beginning of the experimental part, the process of preparation of hydrogél wound dressing was optimised. Subsequently, the dressings were enriched with active compounds and the rate of gradual releasing of the substances into model environment was monitored. In the case of enzymes, their proteolytic activity was also tested after their incorporation to the wound dressings. Furthermore, the prepared bioactive wound dressings were analyzed for possible cytotoxic effect on human keratinocytes. Finally, the wound dressing with combined content of active substances was created and also characterized for the rate of substance release, proteolytic activity and cytotoxicity. Antimicrobial activity of this wound dressings, against two selected strains of microorganisms: Escherichia coli and Staphylococcus epidermidis, was also evaluated.
6

Smith, Annie G., Rachel A. Powis, D. I. Pritchard, and Stephen T. Britland. "Greenbottle (Lucilia Sericata) larval secretions delivered from a prototype hydrogel wound dressing accelerate the closure of model wounds." American Institute of Chemical Engineers (AIChE), 2008. http://hdl.handle.net/10454/4041.

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no
The resurgence of larval biotherapy as a debridement tool in wound management has been accompanied by several clinical reports highlighting concomitant tissue regeneration. Studies employing in vitro cell motility assays have found that purified excretory/secretory (ES) products from Greenbottle larvae (blowfly, Lucilia sericata) are motogenic for human dermal fibroblasts when used as a supplement in culture media. The objective of the present study was to determine whether ES delivered using a prototype hydrogel wound dressing induced similar motogenic effects on fibroblastic (3T3) and epithelial cells (HaCaTs) comprising a scratched-monolayer wound model. Quantitative analysis by MTT assay failed to detect significant mitogenic effects of ES on either cell type. Quantitative image analysis revealed that ES exposure markedly accelerated wound closure through a motogenic effect on both fibroblasts and keratinocytes. Quantitative histochemical analysis detected significantly higher phosphotyrosine (pTyr) expression in ES-exposed cell cultures than in controls; moreover immunocytochemistry revealed conspicuously raised levels of pTyr expression in cells located at the wound margin. By attenuation with a panel of enzyme inhibitors these effects were attributed to the protease components of ES. The present results suggest that controlled delivery of ES as a follow-up to maggot debridement therapy may be an effective therapeutic option for stimulation of tissue regeneration in wound management.
7

Rayment, Erin Alexis. "Investigation into the proteolytic activity in chronic wound fluid and development of a remediation strategy." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16564/.

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Chronic ulcers are an important and costly medical issue, causing their sufferers a large amount of pain, immobility and decreased quality of life. The common pathology in these chronic wounds is often characterised by excessive proteolytic activity, leading to the degradation of both the extracellular matrix, as well as key factors critical to the ulcer's ability to heal. As matrix metalloproteinases (MMPs), a large family of zinc-dependent endopeptidases, have been shown to have increased activity in chronic wound fluid (CWF), it was hypothesised that this specific proteolytic activity was directly related to an ulcer's chronic nature. Although previous studies have identified elevated proteases in CWF, many have reported contradictory results and therefore the precise levels and species of MMPs in CWF are poorly understood. The studies reported herein demonstrate that MMP activity is significantly elevated in CWF compared with acute wound fluid (AWF). In particular, these studies demonstrate that this proteolytic activity can be specifically attributed to MMPs and not another class of proteases present in wound healing. Furthermore, it is shown that MMP-9 is the predominant protease responsible for matrix degradation by CWF and is an indicator of the clinical status of the wound itself. Moreover, MMP-9 can be inhibited with the bisphosphonate alendronate, in the form of a sodium salt, a functionalised analogue, and also tethered to a synthetic biocompatible hydrogel compromised of aqueous poly (2-hydroxy methacrylate) PHEMA synthesised in the presence of poly(ethylene glycol) (PEG). Together, these results highlight the potential use of a tethered MMP inhibitor as an improved ulcer treatment to inhibit protease activity in the wound fluid, while still allowing MMPs to remain active in the wound bed where they perform vital roles in the activation of growth-promoting agents and immune system regulation.
8

Bonacin, Renata Fogaça. "Hidrogéis de PVP e blendas de PVP/polianidridos como potenciais curativos para feridas crônicas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-05122011-140143/.

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Hidrogéis compreendem uma importante classe de materiais poliméricos adequados à aplicação como curativos de feridas e queimaduras. A estrutura tridimensional hidrofílica dos hidrogéis permite que estes mantenham a umidade ideal no leito das feridas, absorvam o exsudato e não causem danos ao novo tecido durante as trocas dos curativos. No caso dos hidrogéis, essas trocas podem ser menos frequentes. Além disso, curativos que auxiliem na remoção de tecidos necrosados e ainda sejam capazes de oferecer tratamentos extras que acelerem o processo de cicatrização são desejáveis. Este trabalho apresenta a produção de materiais à base de hidrogel capazes de auxiliar neste processo de diferentes maneiras. Primeiramente, são apresentados hidrogéis formados a partir de nanofibras de poli(N-vinil-2-pirrolidona) (PVP) produzidas por eletrofiação, seguido da reticulação através da utilização de radiação UV-C ou reação de Fenton. A utilização da eletrofiação como técnica auxiliar na formação dos hidrogéis permitiu o controle da porosidade através da formação de fibras de diferentes diâmetros. A evidência de tal propriedade foi constatada através da produção de materiais que apresentam diferentes perfis de liberação da proteína modelo albumina de soro bovino (BSA). O hidrogel de PVP nanoestruturado foi capaz de liberar e manter a atividade da colagenase, uma importante enzima aplicada no tratamento de feridas via desbridamento enzimático, durante as 48 horas em que foi avaliado. Além disso, hidrogéis bactericidas nanoestruturados foram produzidos a partir de nanocompósitos de PVP e nanopartículas de prata (AgNP) produzidos por eletrofiação. Esses hidrogéis apresentaram propriedades térmicas semelhantes aos hidrogéis sem AgNP, diminuindo, contudo, a sua capacidade de intumescimento. Esses hidrogéis mostraram-se ativos contra bactérias gram-positivas e gram-negativas a partir de 100 ppm de AgNPs. Adicionalmente, foi estudada a formação de um hidrogel modelo composto PVP/AgNP/Imidazol, almejando-se a produção de um material bactericida-fungicida a base de hidrogel. Este hidrogel apresentou atividade conta três espécies de Candida a partir de 500 ppm de imidazol no material. Embora exista a formação de um complexo estável entre AgNP e Imidazol, cálculos teóricos e a constatação da atividade fungicida corroboram com o fato de que derivados imidazólicos podem ser liberados a partir deste hidrogel híbrido. A produção de hidrogéis físicos compostos por blendas de PVP/Polianidridos sintetizados a partir de derivados de hidroxicinamatos e ácido salicílico, capazes de liberar moléculas de interesse biológico quando parcialmente degradados hidroliticamente, também é descrita neste trabalho. Os resultados indicam que interações hidrofóbicas entre a PVP e os polianidridos sintetizados podem ser responsáveis pela formação dos hidrogéis físicos e pela miscibilidade das blendas produzidas. Os hidrogéis físicos de PVP/Polianidridos foram obtidos na forma de filmes por evaporação do solvente. Micro- e nanofibras também foram obtidas por eletrofiação. Desta maneira, o presente trabalho contribui com o desenvolvimento de uma geração de curativos multifuncionais aplicados no tratamento de feridas crônicas e queimaduras.
Hydrogels comprise an important class of polymeric materials that finds application as wound and burn dressings. The hydrophilic three-dimensional structure of hydrogels helps to provide the ideal humidity at the wound bed, to remove exsudates and to prevent damages to the new tissue during dressing substitution. Furthermore, these wound dressings are able to remove necrotic tissues and, therefore, capable to offer extra treatments that would benefit the healing processes. This work describes the production of hydrogel based materials that are able to act in wound healing by different ways. First, it is presented hydrogels composed of poly(N-vinyl-2-pyrrolidone) (PVP) nanofibers produced by electrospinning, followed by its crosslinking using UV-C radiation or Fenton reaction. The use of electrospinning in the hydrogel formation allowed porosity control by obtaining fibers of different diameters. This was evidenced by achieving materials that present different release profiles of the model protein bovine serum albumin (BSA). The nanostructured PVP hydrogel was capable of releasing and maintaining collagenase activity during 48 hour of evaluation. This is an important enzyme that find application in wound healing based on enzymatic debridement. Moreover, nanostructured bactericidal hydrogels were produced from PVP and silver nanoparticles (AgNP) composite through electrospinning, resulting in hydrogels with thermal properties similar to those hydrogels without AgNP, decreasing its swelling ability. These hydrogels were active against gram-positives and gram-negatives bacteria starting from 100 ppm of AgNP. In addition, the production of a model hydrogel composed by PVP/AgNP/Imidazole was investigated, aiming at a bactericidal-fungicidal hydrogel based material. This hydrogel was active against three Candida having 500 ppm of imidazole into the structure. In spite of the formation of a stable complex between AgNP and imidazole, theoretic calculations and the observed fungicidal activity corroborate with the fact that imidazoles derivatives can be released from this hybrid hydrogel. Physical hydrogels composed of PVP/Polyanhydrides blends were synthesized from hydroxycinammates derivatives and salicylic acid. These materials which were capable of releasing molecules with biological potential upon hydrolysis, are also described in this work. The results indicate that hydrophobic interactions between PVP and the synthesized polyanhydrides could be responsible for the hydrogel formation and blend miscibility as well. PVP/Polyanhydride physical hydrogels were obtained from cast films. Micro- and nanofibers were also obtained by electrospinning. Thus, the present work contributes with the development of the new generation of smart dressings for wound and burn healing.
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Desorme, Mylène. "Filage du chitosane pour l’élaboration de textiles biomédicaux innovants." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10112.

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Ce travail concerne le développement de nouvelles méthodes de filage du chitosane ainsi que l’étude des propriétés morphologiques, mécaniques et biologiques des fibres obtenues, en vue de leur utilisation sous forme de fils et textiles dans des applications biomédicales (en particulier, la constitution de prothèses pariétales pour la chirurgie viscérale et de pansements pour le traitement des plaies chroniques). Les monofilaments sont élaborés à partir de solutions hydroalcooliques de chitosane. Les deux procédés décrits sont basés sur la gélification physique du polymère sans utiliser d’agent réticulant externe. L’étude systématique des paramètres physico-chimiques mis en jeu au cours de la formation des fibres a permis de déterminer les paramètres clés permettant le contrôle de la morphologie cristalline des fibres, notamment les fractions cristalline anhydre et hydratée. Les propriétés mécaniques des fibres de chitosane sont stables au moins jusqu'à 6 mois de stockage à l'ambiante, et ont pu être optimisées en jouant à la fois sur des paramètres « procédé » (étirages du filament aux différentes étapes du procédé d’élaboration) et sur des paramètres physicochimiques (concentration en chitosane dans le collodion, masse moléculaire du polymère et composition du solvant hydroalcoolique). L’observation de la morphologie des fibres à différentes échelles par diffusion/diffraction des rayons X et microscopie électronique en relation avec les propriétés mécaniques a permis d’appréhender l'évolution microstructurale au cours de l'étirage, notamment le mécanisme de formation de fibrilles d'une part, et les échelles clés pour l'interprétation du comportement à rupture des fibres (morphologie en agrégats de 100-300 nm). Enfin, une implantation en souscutané chez le rat de fibres de chitosane possédant différentes morphologies cristallines (anhydre et hydratée) a validé le potentiel de ces fibres pour leurs applications biologiques avec une excellente tolérance des biomatériaux implantés (réponses inflammatoire et tissulaire très limitées) et une faible biodégradabilité après 90 jours d'implantation
This work deals with the development of new chitosan fiber spinning processes and the study of morphological, mechanical and biological properties of obtained fibers, in the perspective of their use as yarns or textiles in biomedical applications (in particular, the design of abdominal reinforcement meshes for visceral surgery and wound dressings for the treatment of chronic wounds). The monofilaments were elaborated from hydroalcoholic chitosan solutions. The two processes that we described are based on the physical gelation of the polymer without using any external crosslinking agent. The systematic study of physico-chemical parameters occurring during the fiber formation allowed to determine the key parameters controlling the crystalline morphology of fibers, especially the anhydrous and hydrated crystalline fractions. The mechanical properties of chitosan fibers are stable at least up to 6 months of storage at ambient atmosphere, and were optimized by acting on processing parameters (filament stretching at different steps of its elaboration) and physico-chemical parameters (chitosan concentration in the dope, molecular weight of the polymer and composition of the hydroalcoholic solvent). The observation of the fiber morphology at different length scales by X-ray diffusion/diffraction and electronic microscopy in relation to their mechanical properties allowed us to comprehend the microstructural evolution during fiber stretching, including the mechanism of fibril formation and the key length scales to understand the behaviour at break of fibers (100-300 nm aggregate morphology). Finally, a subcutaneous implantation of chitosan fibers with different crystalline morphologies (anhydrous and hydrated) validated the potential of these fibers in their biological applications with an excellent tolerance of implanted biomaterials (very low inflammatory and tissue reactions) and a low biodegradability after 90 days of implantation
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Buddhiranon, Sasiwimon. "Phytochemical Modification of Biodegradable/Biocompatible Polymer Blends with Improved Immunological Responses." University of Akron / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=akron1352951953.

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Частини книг з теми "Hydrogel wound dressings":

1

Huang, Kang-Ting, and Chun-Jen Huang. "Novel Zwitterionic Nanocomposite Hydrogel as Effective Chronic Wound Healing Dressings." In IFMBE Proceedings, 35–38. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-12262-5_11.

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Mulder, G. D., M. Altman, J. E. Seeley, and T. Tintle. "A Prospective Randomized Study of the Efficacy of Hydrogel, Hydrocolloid, and Saline Moistened Dressings on the Management of Pressure Ulcers." In Wound Healing and Skin Physiology, 703–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-77882-7_70.

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3

Nadtoka, O., N. Kutsevol, O. Linnik, and M. Nikiforov. "Nanocomposite Hydrogels Containing Silver Nanoparticles as Materials for Wound Dressings." In Springer Proceedings in Physics, 375–87. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-17755-3_24.

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4

Dalafu, Haydee, Modesto T. Chua, and Soma Chakraborty. "Development of κ-Carrageenan Poly(acrylic acid) Interpenetrating Network Hydrogel as Wound Dressing Patch." In ACS Symposium Series, 125–35. Washington, DC: American Chemical Society, 2010. http://dx.doi.org/10.1021/bk-2010-1054.ch006.

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5

Nguyen, Xuan-Truong, Vo Van Toi, and Thi-Hiep Nguyen. "Development of a New Injectable PVA–Ag NPs/ Chitosan Hydrogel for Wound Dressing Application." In IFMBE Proceedings, 321–24. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11776-8_78.

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6

Bustamante, Paola, Carolina Anessi, Natalia Santoro, Nazarena Ciavaro, and Celina Horak. "Synthesis and Characterization of Hydrogels Cross-Linked with Gamma Radiation for Use as Wound Dressings." In IFMBE Proceedings, 643–51. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-30648-9_85.

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7

Rajan, Aswni Sundara, Kerensa Miriam Sheen, Balaji Sadhasivam, and Nachimuthu Saraswathy. "In-Vitro Wound Healing and Release Kinetics of β-Cyclodextrin Encapsulated Curcumin Loaded Carrageenan Hydrogel Film: An Efficient Wound Dressing Material." In Proceedings of the International Conference on Nanomedicine (ICON-2019), 107–19. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-25135-2_11.

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Mišković-Stanković, Vesna B. "Electrochemical Production of Polymer Hydrogels with Silver Nanoparticles for Medical Applications as Wound Dressings and Soft Tissue Implants." In Modern Aspects of Electrochemistry, 267–375. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31849-3_4.

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9

Meikle, S. T. "Silver-doped hydrogels for wound dressings." In Wound Healing Biomaterials, 335–51. Elsevier, 2016. http://dx.doi.org/10.1016/b978-1-78242-456-7.00016-7.

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Alibolandi, Mona, Elnaz Bagheri, Marzieh Mohammadi, Elham Sameiyan, and Mohammad Ramezani. "Biopolymer-Based Hydrogel Wound Dressing." In Modeling and Control of Drug Delivery Systems, 227–51. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-821185-4.00019-1.

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Тези доповідей конференцій з теми "Hydrogel wound dressings":

1

Zhou, Y. M., T. Mizu, T. Takehisa, K. Haraguchi, and Y. Taenaka. "Nanocomposite hydrogels : A novel wound dressings." In 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI). IEEE, 2010. http://dx.doi.org/10.1109/bmei.2010.5639558.

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2

Putri, Nandita Melati, Prasetyanugraheni Kreshanti, Narottama Tunjung, Alita Indania, Adi Basuki, and Chaula L. Sukasah. "Efficacy of honey dressing versus hydrogel dressing for wound healing." In THE 5TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the 5th International Symposium of Biomedical Engineering (ISBE) 2020. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0047363.

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3

Aykaç, Ahmet, and İzel Ok. "Investigations and Concerns about the Fate of Transgenic DNA and Protein in Livestock." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.046.

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Hydrogels are biocompatible and swollen materials that have been used as a wound dressing for years. Among them, chitosan-based hydrogels have become popular in the wound healing process owing to their low toxic, biocompatible, biodegradable, antibacterial properties. Chitosan (CS) has been used either as a pure form or incorporated with polymers or nanoparticles to increase antimicrobial activity and stability. In this context, zinc oxide nanoparticles (ZnO NPs) have been used to enhance antibacterial activity and mesoporous silica nanoparticles (MSN) have been employed to develop mechanical strength and control of drug release time. In this study, we report the synthesis and fully characterizations of ZnO NPs, MSN and the hydrogel by using dynamic light scattering (DLS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR). We have also prepared and characterized chitosan-based hydrogels functionalized by MSNs and ZnO NPs.
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Syed, Raza ur Rehman, Robin augustine, Alap ali Zahid, and Anwarul Hasan. "Conjugation of CTGF with Reduced Graphene Oxide Nanoparticles for the Development of Wound Healing Hydrogel Patch." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0180.

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Non-healing chronic wounds are the key concern in type-2 diabetes that frequently leads to chronic infections, finally causing amputation of limbs, organs etc. Decrease in the proliferation and migration of cells such as keratinocytes and fibroblasts is the major reason for the development of such chronic diabetic wounds. Multiple evidences have shown that CTGF and reduced graphene oxide possesses angiogenic property and promote wound healing by promoting proliferation and migration of fibroblasts and keratinocytes cells.Conjugation of rGO with CTGF using EDC-NHS chemistry is a novel approach to accelerate the wound healing process. In the current work, we have developed a rGO/CTGF incorporated GelMA hydrogel dressing to improve wound healing by increasing proliferation and migration of cells as well as promoting formation of new blood vessels for increased supply of nutrients, oxygen and growth factors to wound area
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Ponco, A., and H. Helmiyati. "Hydrogel of carboxymethyl cellulose and polyvinyl alcohol modified by CuNPs as antibacterial in wound dressing." In PROCEEDINGS OF THE 5TH INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES (ISCPMS2019). AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0008096.

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6

Goekbora, B., C. Pomerantz, N. Premnath, and R. Stevenson. "A Hydrogel Wound Dressing with Gradient Crosslinking and Silver/Copper Ions for Treatment of Severe Burns." In 2013 39th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2013. http://dx.doi.org/10.1109/nebec.2013.40.

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7

Rajan, Aswni Sundara, Kerensa Miriam Sheen, Balaji Sadhasivam, Dymphan Fidelics Gonsalves, and Saraswathy Nachimuthu. "Carrageenan hydrogel loaded with Pluronic®F68/Curcumin: An efficient dressing material for chronic wounds." In PROCEEDINGS OF ADVANCED MATERIAL, ENGINEERING & TECHNOLOGY. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0019757.

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Rusu, Alina Gabriela, Ioana Alexandra Tanasa, Marcel Ionel Popa, Maria Butnaru, and Liliana Verestiuc. "Development of novel hydrogels based on citraconyl-chitosan and poly(acrylic acid) as potential wound dressing materials." In 2015 E-Health and Bioengineering Conference (EHB). IEEE, 2015. http://dx.doi.org/10.1109/ehb.2015.7391527.

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Haryanto, Dewi Hardiningrum F., and Deni Swantomo. "Modification of polyethylene oxide-polyethylene glycol dimethacrylate hydrogel film by the addition of Jatropha multifida sap for wound dressing application." In THE 11TH REGIONAL CONFERENCE ON CHEMICAL ENGINEERING (RCChE 2018). Author(s), 2019. http://dx.doi.org/10.1063/1.5095039.

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Erceg, Tamara, Gaja Brakus, Dejan Kojić, Nevena Vukić, Vesna Teofilović, Jelena Tanasić, and Ivan Ristić. "DESCRIPTION OF CHITOSANE GRAFTED ACRYLIC ACID BASED HYDROGEL SWELLING KINETICS AND THEIR USE IN NEW DESIGNED SYSTEM." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.418e.

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Chitosan based hydrogel was synthesized via free-radical polymerization in a two-step procedure, after modification of chitosan by acrylic acid. Dynamic swelling test was carried out in distilled water at room temperature. Swelling kinetics was modeling using the principle of assuming the equation for a swelling ratio-time empirical dependence. Using regression analysis in this way gives the possibility for simpler determination of swelling ratio-time empirical dependence, knowing the graph functions. Obtained hydrogel was used for preparation of new bilayer hydrogel system which has potential application in wound dressing systems and other fields where pH sensitivity and improved mechanical properties of biopolymers are required in framework of green, cost-effective process.

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