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1

Maharramova, Sevinc, Mahbuba Veliyeva, Mahira Amirova, Ulviyya Azizova, Ulker Majidova, Huseyn Abıyev, Gulnara Dashdamirova, and Farah Mammadova. "Surrounding Plants as Reliable Immune Boosters." Health 14, no. 11 (2022): 1105–13. http://dx.doi.org/10.4236/health.2022.1411078.

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2

Hoseinzadeh, Fatemeh, Porya Hassan Abadi, Mehdi Agheltar, Arvin Aghayinejad, Farnaz Torabian, Arash Akhavan Rezayat, Farzad Akbarzadeh, and Hamid Reza Rahimi. "The Role of Immune System in Depression Disorder." Health 08, no. 15 (2016): 1726–43. http://dx.doi.org/10.4236/health.2016.815167.

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3

Ruan, Tao, Lingjun Li, Xi Peng, and Bangyuan Wu. "Effects of Methionine on the Immune Function in Animals." Health 09, no. 05 (2017): 857–69. http://dx.doi.org/10.4236/health.2017.95061.

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4

Yan, Fang, and D. B. Polk. "Probiotics and immune health." Current Opinion in Gastroenterology 27, no. 6 (November 2011): 496–501. http://dx.doi.org/10.1097/mog.0b013e32834baa4d.

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5

Rani, Usha. "Breastfeeding: Importance in Early Development of the Immune System and Long-term Health." Journal of Communicable Diseases 52, no. 02 (June 30, 2022): 107–9. http://dx.doi.org/10.24321/0019.5138.202280.

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Breastfeeding supplies the baby and infant with unparalleled natural nutrients. Human breast milk also has several antimicrobial agents and may influence immune system development, as evidenced by prior research on newborn immunisation response and thymus gland development. Human milk is a dynamic supply of nutrients and bioactive ingredients and promotes the healthy growth and development of the human newborn. Infants are more susceptible to infection because their developing immune systems have a number of weaknesses. This review focuses on the direct effect of human milk on innate immunity in infants. Numerous new studies have made the multi-functionality of the bioactive components of human milk very clear. Our knowledge of the potential positive effects of human milk on infants has increased. These effects are not achievable with milk formulae. Human milk contains antimicrobial proteins and peptides that have a broader involvement in innate immune defence than previously thought. A complex combination of the anti-inflammatory and antioxidative substances that human milk supplies to the intestine results in a special environment of improved immune defence with reduced inflammation.
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6

Minton, Kirsty. "Linking immune and emotional health." Nature Reviews Immunology 13, no. 9 (August 23, 2013): 617. http://dx.doi.org/10.1038/nri3529.

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7

Liu, Baochi, Meng Wang, Jinsong Su, Yanzheng Song, Li Liu, and Lei Li. "Correlation analysis of compromised immune function with perioperative sepsis in HIV-positive patient." Health 04, no. 04 (2012): 190–95. http://dx.doi.org/10.4236/health.2012.44028.

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8

Wei, Xiangdong, Bin Zhang, and Baojun Pan. "MMP1 Is a Prognostic-Related Biomarker and Correlated with Immune Infiltration in Breast Cancer." Health 14, no. 02 (2022): 219–35. http://dx.doi.org/10.4236/health.2022.142017.

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9

Dietert, Rodney, and Judith Zelikoff. "Pediatric Immune Dysfunction and Health Risks Following Early-Life Immune Insult." Current Pediatric Reviews 5, no. 1 (February 1, 2009): 36–51. http://dx.doi.org/10.2174/157339609787587591.

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10

Chandok, Meena, Palanikumaran Sakthivel, Charles Chaney, Michael Mccormack, Kathryn Wagner, Gary Mire, John Newby, Anil Parwani, and Kathleen Renee. "Novel early detection test for breast cancer and its recurrence in blood through changes in immuno-biochemical signals (46.12)." Journal of Immunology 188, no. 1_Supplement (May 1, 2012): 46.12. http://dx.doi.org/10.4049/jimmunol.188.supp.46.12.

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Abstract We are developing an immune sensor for early detection of breast cancer and its recurrence in blood, based on identifying the earliest specific changes/alterations in the immuno-biochemical signals in different immune components that are distinctly different from those in a healthy immune system. The screening of different immuno-biochemical signals in their native and altered forms in different immune components/cells led to identification of a novel T cell population. Analysis of this T cell population and its immuno-biochemical signals on blood samples from the 4 groups - (i) healthy, (ii) recently diagnosed with invasive breast cancer stage 1{before the onset of treatment/surgery}, (iii) breast cancer treated individuals who had incidence of recurrence/relapse {BCR}, and (iv) breast cancer treated individuals who were disease free {BDF}- was done using multi-parameter flow cytometry. Sixteen molecules, assessed as the most likely candidates for sensing disruptions in the immune pathway, were used in developing a matrix. Care was taken to separate subjects that could confound the immuno-biochemical signals, potentially arising from other immune disorders. The method designed is different from conventional approaches and has the potential to be used as a cost-effective assessment to predict health status.
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11

Lee, Heung Kyu, and Doo Hyun Chung. "Immune Networks in Health and Disease." Molecules and Cells 44, no. 5 (May 31, 2021): 279–80. http://dx.doi.org/10.14348/molcells.2021.0117.

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12

刘, 薇薇. "Stachyose Health Function and Immune Regulation." Hans Journal of Food and Nutrition Science 02, no. 02 (2013): 21–24. http://dx.doi.org/10.12677/hjfns.2013.22005.

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13

Hogrefe, Christine. "Immune Health: The Animal-Human Connection." Allergy & Clinical Immunology International - Journal of the World Allergy Organization 17, no. 05 (2005): 212–13. http://dx.doi.org/10.1027/0838-1925.17.5.212.

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14

Harrington, Monica. "Dirty living breeds better immune health." Lab Animal 39, no. 1 (January 2010): 2. http://dx.doi.org/10.1038/laban0110-2a.

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15

Huntington, Nicholas D., and Daniel HD Gray. "Immune homeostasis in health and disease." Immunology and Cell Biology 96, no. 5 (May 2018): 451–52. http://dx.doi.org/10.1111/imcb.12043.

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16

McGhee, Sean A. "Public health comes to immune deficiency." Blood 119, no. 11 (March 15, 2012): 2433–35. http://dx.doi.org/10.1182/blood-2011-12-397836.

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17

Gouin, Jean-Philippe. "Chronic Stress, Immune Dysregulation, and Health." American Journal of Lifestyle Medicine 5, no. 6 (January 20, 2011): 476–85. http://dx.doi.org/10.1177/1559827610395467.

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Анотація:
In the past 40 years, a growing body of literature has shown that chronic psychological stress can lead to immune dysregulation. Notably, these stress-induced immune changes are large enough to be clinically relevant. Chronic stress has been associated with a state of chronic low-grade inflammation, delayed wound healing, poor responses to vaccine, and increased susceptibility to infectious illnesses. Activation of neuroendocrine and sympathetic systems provides physiological pathways linking stress and these immune outcomes. Behavioral changes under conditions of chronic stress also contribute to immune dysregulation. Behavioral and pharmacological interventions may attenuate stress-induced immune dysregulation.
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18

Glaser, Ronald, John Rice, John Sheridan, Richard Fertel, Julie Stout, Carl Speicher, David Pinsky, et al. "Stress-related immune suppression: Health implications." Brain, Behavior, and Immunity 1, no. 1 (March 1987): 7–20. http://dx.doi.org/10.1016/0889-1591(87)90002-x.

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19

Tufail, Tabussam, Farhan Saeed, Huma Bader Ul Ain, Bushra Niaz, Muhammad Afzaal, Ahmad Din, and Hafiz Ansar Rasul Suleria. "Cashew nut allergy; immune health challenge." Trends in Food Science & Technology 86 (April 2019): 209–16. http://dx.doi.org/10.1016/j.tifs.2019.02.014.

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20

Davies, Graham E. "Immune mechanisms and immune deficiency." Current Opinion in Pediatrics 2, no. 1 (February 1990): 106–9. http://dx.doi.org/10.1097/00008480-199002000-00020.

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21

Friedland, Leonard. "VACCINATION TO PROMOTE HEALTH THROUGHOUT LIFE AS A HEALTHY AGING STRATEGY." Innovation in Aging 3, Supplement_1 (November 2019): S211. http://dx.doi.org/10.1093/geroni/igz038.771.

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Анотація:
Abstract This symposium addresses the role of vaccination to promote healthy aging, the process of developing and maintaining the functional ability that enables wellbeing in older age. Life-span immunization of adults across all age categories can help to reduce morbidity and mortality. Healthy aging is critical for our global society to counter the surge in healthcare costs that is coming as a result of the demographic shift to older age. Immune system function and response to vaccination declines with advancing age. Generating effective immune responses against new infectious disease targets can be difficult in older individuals. Important progress has been made in understanding the mechanisms underlying immunosenescence, the age-related decline of the immune response to infections and vaccinations. Innovative research and the development of new technologies, such as adjuvants, substances that can enhance and shape the immune response to the target antigen(s), has facilitated the development of vaccines specially tailored for adults. This evidence-based approach to the development of innovative vaccines addressing immunosenescence is an important clinically relevant healthy aging strategy to promote health throughout life.
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22

Vandenplas, Y. "Healthy gut microbiota and long term health." Beneficial Microbes 6, no. 2 (January 1, 2015): 173–79. http://dx.doi.org/10.3920/bm2014.0072.

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Анотація:
This review summarises how the composition of the gastro-intestinal microbiota depends on pre- and postnatal factors, and birth itself. The impact of method of delivery, feeding during infancy and medications, such as antibiotics and anti-acid medication, on the composition of the gastro-intestinal microbiota has clearly been shown. However, the duration of the impact of these factors is not well established. The gastro-intestinal microbiome composition is associated with many auto-immune mediated diseases. Although causality has not been obviously demonstrated, there is a strong tendency in this direction. Nevertheless, results of the manipulation of the gastro-intestinal microbiome composition in these conditions are often disappointing. A better understanding on factors determining the longterm composition of the gastro-intestinal microbiome and its health consequences are a priority research topic. A better understanding of the association between the microbiome and the immune system may have a tremendous impact on general health.
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23

Kohut, Marian L. "Immune Function." American Journal of Lifestyle Medicine 10, no. 3 (February 15, 2016): 174–77. http://dx.doi.org/10.1177/1559827616631723.

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24

Pang, Tikki. "From immune system to health systems − Challenges for health research." Immunology & Cell Biology 82, no. 2 (April 2004): 149–53. http://dx.doi.org/10.1046/j.0818-9641.2004.01222.x.

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25

Baquir, Beverlie, and Robert E. W. Hancock. "Exosomes, your body’s answer to immune health." Annals of Translational Medicine 5, no. 4 (February 2017): 81. http://dx.doi.org/10.21037/atm.2017.01.50.

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26

Toptygina, A. P. "Heterologous immune responses in health and disease." Russian Journal of Infection and Immunity 10, no. 2 (May 22, 2020): 269–76. http://dx.doi.org/10.15789/2220-7619-hir-1292.

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Анотація:
Immunological memory and tolerance represent major achievements and advantages of adaptive immunity. Organisms bearing adaptive immunity display prominent competitive advantages in the fight against infections. Memory immune cells are preserved for decades and are able to repel a second attack of an infectious agent. However, studies performed in the XXI century have shown that even unrelated pathogens may be quickly and effectively destroyed by memory cells. This type of response is called heterologous so that heterologous immune response is mainly typical to viral infections and other intracellular infections, where T-cells play a lead role in protection. This review will discuss various mechanisms involved in implementing T-cell cross-reactivity, describe molecular prerequisites for heterologous T-cell responses. Experimental evidence of memory T-cell potential to heterologous immune response in mouse models and in human infections are also discussed. Heterologous immune response is an important immune arm in adults and the elderly when the yield of naive cells to the periphery declines due to thymus involution. Along with obvious advantages, heterologous immune response leads to imbalanced memory T-cell repertoire, replacement of immunodominant epitopes with minor ones allowing viruses to evade immune response that results in virus persistence, or, conversely, fulminant infection course. Another threat of heterologous immune response due to switch in dominant repertoire of recognizable epitopes is presented by random self-epitope recognition, which can lead to development of autoimmune pathology. Heterologous immunity can also disrupt drug-induced tolerance in organ and tissue transplants and lead to graft rejection. Heterologous immune response should be taken into consideration while developing and using new vaccines, especially in adults and the elderly.
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27

Oliveira, Daniela Cabral, Fábio Roberto Chavarette, and Fernando Parra dos Anjos Lima. "Structural Health Monitoring using Artificial Immune System." Brazilian Journal of Development 6, no. 4 (2020): 16948–63. http://dx.doi.org/10.34117/bjdv6n4-022.

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28

van Schrojenstein Lantman, Marith, Marlou Mackus, Leila Otten, Deborah de Kruijff, Aurora van de Loo, Aletta Kraneveld, Johan Garssen, and Joris Verster. "Mental resilience, perceived immune functioning, and health." Journal of Multidisciplinary Healthcare Volume 10 (March 2017): 107–12. http://dx.doi.org/10.2147/jmdh.s130432.

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29

Rosenblum, Daniel, and Shruti Naik. "Epithelial–immune crosstalk in health and disease." Current Opinion in Genetics & Development 74 (June 2022): 101910. http://dx.doi.org/10.1016/j.gde.2022.101910.

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30

Zabara, D., І. Kozeretska, I. Deineko, Ya Anoshko, N. Shapovalenko, L. Stamboli, and B. Dons’koi. "Immune factors and health of Antarctic explorers." Ukrainian Antarctic Journal, no. 2 (2021): 94–105. http://dx.doi.org/10.33275/1727-7485.2.2021.680.

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The immune system plays a major role in human homeostasis, yet a body’s unique individuality complicates the diagnostic forecasting of unfavourable physiological states and diseases. Studying the immunophenotypic features of winterers of the Ukrainian Antarctic Expeditions before, during, and after their assignments might shed some light on the possible place of immune accentuations in the development of certain physiological states. To determine the natural-killer (NK) cytotoxicity and the immunophenotype in 52 applicants who wanted to take part in an expedition and nine participants who had come back, we used flow cytofluorometry. Blood serum samples taken before, during, and after the expeditions were also tested for hormones, anti-infective, anti-parasitic, and autoimmune antibodies. The high absolute and relative numbers of NK lymphocytes, high NK cytotoxicity, and high expression of HLA-DR on the CD3+CD8+ lymphocytes were correlated with a person’s unfavorable health status during the expedition. In Antarctica, cortisol levels sharply increased, yet they normalized upon return. In most winterers, there were no significant health complications during the expeditions. Neither reactivated nor primary viral infections were registered, as well as clinical autoimmune ones. Upon return, the winterers had significantly lower leukocytes and lymphocytes and increased expression of activation markers (HLA-DR) on the T-cells. The found risk factors can characterize the polar researchers’ immunophenotypes yet require validation on larger samples. The expedition environment causes increased stress, entailing, however, neither clinical manifestations nor elements of immunosuppression. The polar researchers bear the consequences of the prolonged stress that inhibit leucopoiesis as late as six months after their return, which should be considered while reviewing applications for the next season.
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31

Takashino, Nina, Yuki Chiba, and Katsuhito Fuyuki. "Consumer Preference for Immune-Health Promoted Pork." JOURNAL OF RURAL SOCIETY AND ECONOMICS 36, no. 2 (February 1, 2019): 1–8. http://dx.doi.org/10.11617/jrse.36.2_1.

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32

Arehart-Treichel, Joan. "Mental Health Not Immune From Secondhand Smoke." Psychiatric News 45, no. 15 (August 6, 2010): 24. http://dx.doi.org/10.1176/pn.45.15.psychnews_45_15_033.

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33

Scholl, Jamie L., Zach King, Kari Potter, Daniel A. DeCino, Danielle Hertel, Kami Pearson, Eric Graack, Erliang Zeng, Kathleen Brown-Rice, and Gina L. Forster. "Inflammation and Immune Markers in Psychological Health." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.00705.

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34

ESKANDARI, FARIDEH, and ESTHER M. STERNBERG. "Neural-Immune Interactions in Health and Disease." Annals of the New York Academy of Sciences 966, no. 1 (June 2002): 20–27. http://dx.doi.org/10.1111/j.1749-6632.2002.tb04198.x.

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35

Nagura, Hiroshi. "Mucosal Immune System in Health and Disease." Pathology International 42, no. 6 (June 1992): 387–400. http://dx.doi.org/10.1111/j.1440-1827.1992.tb03243.x.

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36

Walsh, Neil P. "Recommendations to maintain immune health in athletes." European Journal of Sport Science 18, no. 6 (April 11, 2018): 820–31. http://dx.doi.org/10.1080/17461391.2018.1449895.

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37

Mašek, K., J. Slánský, P. Petrovický, and J. W. Hadden. "Neuroendocrine immune interactions in health and disease." International Immunopharmacology 3, no. 8 (August 2003): 1235–46. http://dx.doi.org/10.1016/s1567-5769(03)00015-8.

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38

Bendich, Adrianne. "Micronutrients in women’s health and immune function." Nutrition 17, no. 10 (October 2001): 858–67. http://dx.doi.org/10.1016/s0899-9007(01)00649-9.

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39

Verster, J., L. S. Otten, M. Mackus, D. De Kruijff, A. J. A. E. Van de Loo, and J. Garssen. "Mental resilience, perceived health and immune status." European Neuropsychopharmacology 26 (October 2016): S367. http://dx.doi.org/10.1016/s0924-977x(16)31307-4.

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40

Palm, Noah W., Marcel R. de Zoete, and Richard A. Flavell. "Immune–microbiota interactions in health and disease." Clinical Immunology 159, no. 2 (August 2015): 122–27. http://dx.doi.org/10.1016/j.clim.2015.05.014.

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41

Cooke, Reinaldo F. "Effects on Animal Health and Immune Function." Veterinary Clinics of North America: Food Animal Practice 35, no. 2 (July 2019): 331–41. http://dx.doi.org/10.1016/j.cvfa.2019.02.004.

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42

Sternberg, E. M. "Neural-immune interactions in health and disease." Journal of Clinical Investigation 100, no. 11 (December 1, 1997): 2641–47. http://dx.doi.org/10.1172/jci119807.

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43

Glaser, Ronald, and Janice K. Kiecolt-Glaser. "Stress-induced immune dysfunction: implications for health." Nature Reviews Immunology 5, no. 3 (March 2005): 243–51. http://dx.doi.org/10.1038/nri1571.

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44

Nestle, Frank O., Paola Di Meglio, Jian-Zhong Qin, and Brian J. Nickoloff. "Skin immune sentinels in health and disease." Nature Reviews Immunology 9, no. 10 (September 18, 2009): 679–91. http://dx.doi.org/10.1038/nri2622.

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45

Chah, Young Wha, Michael Dougan, Ryan Sullivan, Ashwin Ananthakrishnan, Ramnik Xavier, Hamed Khalili, John Garber, and Vijay Yajnik. "Immune Health and Risk of Ipilimumab Colitis." Gastroenterology 152, no. 5 (April 2017): S194. http://dx.doi.org/10.1016/s0016-5085(17)30955-1.

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46

Tieu, Sophie, Armen Charchoglyan, Lauri Wagter-Lesperance, Khalil Karimi, Byram W. Bridle, Niel A. Karrow, and Bonnie A. Mallard. "Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness." Nutrients 14, no. 19 (September 30, 2022): 4075. http://dx.doi.org/10.3390/nu14194075.

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Анотація:
Knowledge that certain nutraceuticals can modulate the immune system is not new. These naturally occurring compounds are known as immunoceuticals, which is a novel term that refers to products and systems that naturally improve an individual’s immuno-competence. Examples of immunoceuticals include vitamin D3, mushroom glycans, flavonols, quercetin, omega-3 fatty acids, carotenoids, and micronutrients (e.g., zinc and selenium), to name a few. The immune system is a complex and highly intricate system comprising molecules, cells, tissues, and organs that are regulated by many different genetic and environmental factors. There are instances, such as pathological conditions, in which a normal immune response is suboptimal or inappropriate and thus augmentation or tuning of the immune response by immunoceuticals may be desired. With infectious diseases, cancers, autoimmune disorders, inflammatory conditions, and allergies on the rise in both humans and animals, the importance of the use of immunoceuticals to prevent, treat, or augment the treatment of these conditions is becoming more evident as a natural and often economical approach to support wellness. The global nutraceuticals market, which includes immunoceuticals, is a multi-billion-dollar industry, with a market size value of USD 454.55 billion in 2021, which is expected to reach USD 991.09 billion by 2030. This review will provide an overview of the immune system, the importance of immunomodulation, and defining and testing for immunocompetence, followed by a discussion of several key immunoceuticals with clinically proven and evidence-based immunomodulatory properties.
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47

Korhonen, Hannu, P. Marnila, and H. S. Gill. "Bovine milk antibodies for health." British Journal of Nutrition 84, S1 (November 2000): 135–46. http://dx.doi.org/10.1017/s0007114500002361.

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Анотація:
The immunoglobulins of bovine colostrum provide the major antimicrobial protection against microbial infections and confer a passive immunity to the newborn calf until its own immune system matures. The concentration in colostrum of specific antibodies against pathogens can be raised by immunising cows with these pathogens or their antigens. Immune milk products are preparations made of such hyperimmune colostrum or antibodies enriched from it. These preparations can be used to give effective specific protection against different enteric diseases in calves and suckling pigs. Colostral immunoglobulin supplements designed for farm animals are commercially available in many countries. Also, some immune milk products containing specific antibodies against certain pathogens have been launched on the market. A number of clinical studies are currently in progress to evaluate the efficacy of immune milks in the prevention and treatment of various human infections, including those caused by antibiotic resistant bacteria. Bovine colostrum-based immune milk products have proven effective in prophylaxis against various infectious diseases in humans. Good results have been obtained with products targeted against rotavirus,Shigella flexneri,Escherichia coli,Clostridium difficile,Streptococcus mutans,Cryptosporidium parvumandHelicobacter pylori. Some successful attempts have been made to use immune milk in balancing gastrointestinal microbial flora. Immune milk products are promising examples of health-promoting functional foods, or nutraceuticals. This review summarises the recent progress in the development of these products and evaluates their potential as dietary supplements and in clinical nutrition.
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Cong, Lei, Phil Bremer, William Kaye-Blake, and Miranda Mirosa. "Chinese consumers’ perceptions of immune health and immune-boosting remedies including functional foods." Journal of Food Products Marketing 26, no. 1 (January 2, 2020): 55–78. http://dx.doi.org/10.1080/10454446.2020.1720885.

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49

Watanabe, Mayumi, Osamu Takano, Chikako Tomiyama, Hiroaki Matsumoto, Nobuatsu Urahigashi, Eisuke Kainuma, Takeo Madarame, Minoru Fukuda, and Toru Abo. "The effects of application of an ancient type of acupuncture needle on body temperature, immune function and the autonomic nerve system." Health 04, no. 10 (2012): 775–80. http://dx.doi.org/10.4236/health.2012.410120.

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50

Phelps, Jerry. "Headliners: Immune Response." Environmental Health Perspectives 111, no. 10 (August 1, 2003): a521. http://dx.doi.org/10.1289/ehp.111-a521.

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