Статті в журналах: "Immune-modulatory effects"

1

Stevens, Dennis L. "Immune modulatory effects of antibiotics." Current Opinion in Infectious Diseases 9, no. 3 (June 1996): 165–70. http://dx.doi.org/10.1097/00001432-199606000-00007.

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2

Zeiser, Robert. "Immune modulatory effects of statins." Immunology 154, no. 1 (February 20, 2018): 69–75. http://dx.doi.org/10.1111/imm.12902.

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3

Zweegman, S., J. J. W. M. Janssen, and H. M. Lokhorst. "Immune-modulatory effects of bortezomib in GVHD." Leukemia & Lymphoma 48, no. 5 (January 2007): 853–54. http://dx.doi.org/10.1080/10428190701297394.

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4

KLAESSON, S., O. RINGDEN, L. MARKLING, M. REMBERGER, and I. LUNDKVIST. "Immune Modulatory Effects of Immunoglobulins on Cell-Mediated Immune Responses In Vitro." Scandinavian Journal of Immunology 38, no. 5 (November 1993): 477–84. http://dx.doi.org/10.1111/j.1365-3083.1993.tb02591.x.

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5

Pellom, Samuel Troy, Duafalia Fred Dudimah, Menaka Chanu Thounaojam, Thomas Joseph Sayers, and Anil Shanker. "Modulatory effects of bortezomib on host immune cell functions." Immunotherapy 7, no. 9 (September 2015): 1011–22. http://dx.doi.org/10.2217/imt.15.66.

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6

Siddiqui, Maheen, Judhell S. Manansala, Hana A. Abdulrahman, Gheyath K. Nasrallah, Maria K. Smatti, Nadin Younes, Asmaa A. Althani, and Hadi M. Yassine. "Immune Modulatory Effects of Vitamin D on Viral Infections." Nutrients 12, no. 9 (September 21, 2020): 2879. http://dx.doi.org/10.3390/nu12092879.

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Viral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the skeletal system in the human body. Recent evidence has indicated that vitamin D also plays an essential role in the immune response against viral infections and suggested that vitamin D deficiency increases susceptibility to viral infections as well as the risk of recurrent infections. For instance, low serum vitamin D levels were linked to increased occurrence of high burdens viral diseases such as hepatitis, influenza, Covid-19, and AIDS. As immune cells in infected patients are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D-deficient individuals with an infectious disease may extend beyond the impact on bone and calcium homeostasis. Even though numerous studies have highlighted the effect of vitamin D on the immune cells, vitamin D’s antiviral mechanism has not been fully established. This paper reviews the recent mechanisms by which vitamin D regulates the immune system, both innate and adaptive systems, and reflects on the link between serum vitamin D levels and viral infections.

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7

Bahadar, Haji, Mohammad Abdollahi, Faheem Maqbool, Maryam Baeeri, and Kamal Niaz. "Mechanistic Overview of Immune Modulatory Effects of Environmental Toxicants." Inflammation & Allergy-Drug Targets 13, no. 6 (June 15, 2015): 382–86. http://dx.doi.org/10.2174/1871528114666150529103003.

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8

FUCHSLUGER, T. "Immune modulatory effects of gene therapy to corneal grafts." Acta Ophthalmologica 90 (August 6, 2012): 0. http://dx.doi.org/10.1111/j.1755-3768.2012.2745.x.

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9

Sinha, M., M. Griffith, C. Betts, G. Choe, S. Sivagnanam, A. Cheung, W. Tamaki, et al. "Immune modulatory effects of ibrutinib in pancreatic ductal adenocarcinoma." Annals of Oncology 30 (July 2019): iv40. http://dx.doi.org/10.1093/annonc/mdz155.145.

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10

De Pablo, Manuel A., and Gerardo Álvarez De Cienfuegos. "Modulatory effects of dietary lipids on immune system functions." Immunology and Cell Biology 78, no. 1 (February 2000): 31–39. http://dx.doi.org/10.1046/j.1440-1711.2000.00875.x.

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11

Melchionda, Fraia, Terry J. Fry, and Crystal L. Mackall. "Harnessing the immune modulatory effects of IL7 for immunotherapy." Clinical and Applied Immunology Reviews 4, no. 2 (September 2003): 71–89. http://dx.doi.org/10.1016/s1529-1049(03)00046-1.

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Schuhladen, Katharina, Lena Stich, Jochen Schmidt, Alexander Steinkasserer, Aldo R. Boccaccini, and Elisabeth Zinser. "Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependent in vitro modulation of murine dendritic cells." Biomaterials Science 8, no. 8 (2020): 2143–55. http://dx.doi.org/10.1039/c9bm01691k.

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13

Dargahi, Narges, Joshua C. Johnson, and Vasso Apostolopoulos. "Immune Modulatory Effects of Probiotic Streptococcus thermophilus on Human Monocytes." Biologics 1, no. 3 (November 19, 2021): 396–415. http://dx.doi.org/10.3390/biologics1030023.

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Ingesting probiotics contributes to the development of a healthy microflora in the GIT with established benefits to human health. Some of these beneficial effects may be through the modulation of the immune system. In addition, probiotics have become more common in the treatment of many inflammatory and immune disorders. Here, we demonstrate a range of immune modulating effects of Streptococcus thermophilus by human monocytes, including decreased mRNA expression of IL-1R, IL-18, IFNαR1, IFNγR1, CCL2, CCR5, TLR-1, TLR-2, TLR-4, TLR-5, TLR-6, TLR-8, CD14, CD86, CD4, ITGAM, LYZ, TYK2, IFNR1, IRAK-1, NOD2, MYD88, SLC11A1, and increased expression of IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-23, IFNγ, TNFα, CSF-2. The routine administration of Streptococcus thermophilus in fermented dairy products and their consumption may be beneficial to the treatment/management of inflammatory and autoimmune diseases.

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14

Oppong-Damoah, Aboagyewaah, Sarah E. Abney, Brenda M. Gannon, Bruce E. Blough, Peter N. Uchakin, and Kevin S. Murnane. "Immune Modulatory Effects of Caryophyllene Oxide in Alcohol Related Behaviors." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.05084.

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15

Ferenčík, M., and L. Ebringer. "Modulatory effects of selenium and zinc on the immune system." Folia Microbiologica 48, no. 3 (May 2003): 417–26. http://dx.doi.org/10.1007/bf02931378.

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16

Islam, Mohammad Rafiqul, Yoon-Seok Roh, Ara Cho, Jinho Kim, Jong-Hoon Kim, Seong-kug Eo, Chae-Woong Lim, and Bumseok Kim. "Immune modulatory effects of the foodborne contaminant citrinin in mice." Food and Chemical Toxicology 50, no. 10 (October 2012): 3537–47. http://dx.doi.org/10.1016/j.fct.2012.06.050.

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17

Srivastava, Shivani, Vishakha Anand Pawar, Anuradha Tyagi, Kanti Prakash Sharma, Vinay Kumar, and Surendra Kumar Shukla. "Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions." Immuno 3, no. 1 (December 25, 2022): 1–15. http://dx.doi.org/10.3390/immuno3010001.

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Interceding nutrients have been acquiring increased attention and prominence in the field of healing and deterrence of various disorders. In this light, the present article encompasses several facets of ketogenic diet as an immunomodulator with respect to its expansive clinical applications. Accordingly, several scientific records, models, and case histories, including viral infections, cancer, chronic diseases, e.g., cardiovascular diseases, epilepsy, as well as numerous other neuro-disorders, are assembled, revealing a profound influence of KD in favor of improvement in the patient’s condition. We accentuate possible manifold mechanisms of KD that require further exploration.

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18

Bacha, Umar, Muhammad Nasir, Sanaullah Iqbal та Aftab Ahmad Anjum. "Nutraceutical, Anti-Inflammatory, and Immune Modulatory Effects ofβ-Glucan Isolated fromYeast". BioMed Research International 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8972678.

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β-Glucan is a dietary fibre, found in many natural sources, and controls chronic metabolic diseases effectively. However,β-glucan from theyeasthas rarely been investigated. Objectively, conditions were optimized to isolateβ-glucan from the yeast (max. 66% yield); those optimized conditions included 1.0 M NaOH, pH 7.0, and 90°C. The purity and identity of the isolatedβ-glucan were characterized through FT-IR, SEM, DSC, and physicofunctional properties. The obtained results from DSC revealed highly stableβ-glucan (m.p., 125°C) with antioxidant activity (TAC value 0.240 ± 0.0021 µg/mg, H2O2scavenging 38%), which has promising bile acid binding 40.463% and glucose control (in vitro). In line with these results, we evaluated the in vivo anti-inflammatory potential, that is, myeloperoxidase activity and reduction in MDA and NO; protective effect on proteins and keeping viscosity within normal range exhibited improvement. Also, the in vivo cholesterol binding and reduction in the skin thickness byβ-glucan were highly encouraging. Finally, our results confirmed that yeastβ-glucan is effective against some of the inflammatory and oxidative stress markers studied in this investigation. In general, the effect of 4% β-glucan was more noticeable versus 2% β-glucan. Therefore, our results support the utilization ofβ-glucan as a novel, economically cheap, and functional food ingredient.

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19

Fang, Ping, Li Zhou, Yuqi Zhou, Jay K. Kolls, Tao Zheng, and Zhou Zhu. "Immune Modulatory Effects of IL-22 on Allergen-Induced Pulmonary Inflammation." PLoS ONE 9, no. 9 (September 25, 2014): e107454. http://dx.doi.org/10.1371/journal.pone.0107454.

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20

Göhner, Claudia, Torsten Plösch, and Marijke M. Faas. "Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia." Placenta 60 (December 2017): S41—S51. http://dx.doi.org/10.1016/j.placenta.2017.06.004.

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21

Rückert, Michael, Lisa Deloch, Rainer Fietkau, Benjamin Frey, Markus Hecht, and Udo S. Gaipl. "Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies." Strahlentherapie und Onkologie 194, no. 6 (March 2, 2018): 509–19. http://dx.doi.org/10.1007/s00066-018-1287-1.

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22

Fang, Ping. "Immune Modulatory Effects of IL-22 On Allergen-Induced Pulmonary Inflammation." Journal of Allergy and Clinical Immunology 131, no. 2 (February 2013): AB191. http://dx.doi.org/10.1016/j.jaci.2012.12.1351.

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23

Lin, Yu-Yang, Ching-Ting Tan, Chia-Wei Chen, Da-Liang Ou, Ann-Lii Cheng, and Chiun Hsu. "Immunomodulatory Effects of Current Targeted Therapies on Hepatocellular Carcinoma: Implication for the Future of Immunotherapy." Seminars in Liver Disease 38, no. 04 (October 24, 2018): 379–88. http://dx.doi.org/10.1055/s-0038-1673621.

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AbstractMultikinase inhibitors with antiangiogenic properties used to be standard therapy for patients with advanced hepatocellular carcinoma (HCC). Recently, several antiangiogenic agents (lenvatinib, cabozantinib, and ramucirumab) have demonstrated antitumor activity for advanced HCC in randomized controlled trials. However, the landscape of drug development for HCC may change dramatically with the advent of immune checkpoint inhibitor therapy, particularly the anti–programmed cell death-1 (anti-PD1) agents. In addition, early-phase clinical trials of combination of anti–PD-1 and antiangiogenic agents have shown very promising anti-tumor activity in patients with advanced HCC. Therefore, the critical research questions at present are whether this combination strategy will be the next generation of standard therapy and which antiangiogenic agents will be the optimal partner for the combination. All of the 4 multikinase inhibitors for HCC (sorafenib, regorafenib, lenvatinib, and cabozantinib) have been reported to have immune modulatory effects. The authors systematically reviewed the pre-clinical evidence of their immune modulatory effects to explore whether these effects were mediated by angiogenesis inhibition or by other “off-target” effects on the tumor microenvironment. Studies of sorafenib comprised the majority (58 of the 71) of the research articles reviewed. Potentially beneficial effects on anti-tumor immunity may result from increased M1 polarization of macrophages and stimulation of CD8 T cell function. On the other hand, high dosage of the kinase inhibitors in pre-clinical models and hypoxia associated with angiogenesis may contribute to immune suppression in the tumor microenvironment. Sorafenib and other multikinase inhibitors may promote anti-tumor immunity through modulation of multiple immune cell types as well as the tumor microenvironment. The optimal immune modulatory dosage should be defined to facilitate design of future combination regimens.

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Mitsios, Alexandros, Akrivi Chrysanthopoulou, Athanasios Arampatzioglou, Iliana Angelidou, Veroniki Vidali, Konstantinos Ritis, Panagiotis Skendros, and Dimitrios Stakos. "Ticagrelor Exerts Immune-Modulatory Effect by Attenuating Neutrophil Extracellular Traps." International Journal of Molecular Sciences 21, no. 10 (May 21, 2020): 3625. http://dx.doi.org/10.3390/ijms21103625.

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Neutrophils through the release of neutrophil extracellular traps (NETs) containing active tissue factor (TF) are key components of thrombo-inflammation. Platelets-neutrophils interplay in ST elevation myocardial infarction (STEMI) promotes NET formation via inorganic polyphosphates (polyP) released by thrombin-activated platelets. NETs, however, are also induced by biomaterials in a platelet-independent manner. Considering the possible pleiotropic effects of Ticagrelor beyond platelet inhibition and the clinical need for novel antithrombotic strategies targeting inflammation, we investigated the effects of Ticagrelor on polyP and stent-induced NETs in STEMI. Neutrophils from healthy individuals and patients receiving Ticagrelor were stimulated with polyP or drug-eluting stents (DES) to produce NETs. To induce TF expression, neutrophils were further incubated with plasma obtained from the infarct-related artery (IRA) of STEMI patients. The effects of Ticagrelor on NETs and TF loading were assessed using fluorescence microscopy, flow cytometry, myeloperoxidase(MPO)/DNA complex ELISA, and a Western blot. Ticagrelor interrupts platelet–neutrophil interaction by attenuating NETs induced by polyP. However, Ticagrelor does not affect polyP secretion from thrombin-activated platelets. Similarly, the intracellular production of TF in neutrophils triggered by IRA plasma is not hindered by Ticagrelor. Furthermore, DES induce NETs and synchronous stimulation with IRA plasma leads to the formation of thrombogenic TF-bearing NETs. Ticagrelor inhibits stent-induced NET release. These findings suggest a novel immune-modulatory effect of Ticagrelor when it attenuates the formation of thrombogenic NETs.

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Mousavi, Soraya, Dennis Weschka, Stefan Bereswill, and Markus Heimesaat. "Immune-Modulatory Effects upon Oral Application of Cumin-Essential-Oil to Mice Suffering from Acute Campylobacteriosis." Pathogens 10, no. 7 (June 29, 2021): 818. http://dx.doi.org/10.3390/pathogens10070818.

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Human campylobacteriosis, commonly caused by Campylobacter jejuni, is a food-borne infection with rising prevalence causing significant health and socioeconomic burdens worldwide. Given the threat from emerging antimicrobial resistances, the treatment of infectious diseases with antibiotics-independent natural compounds is utmost appreciated. Since the health-beneficial effects of cumin-essential-oil (EO) have been known for centuries, its potential anti-pathogenic and immune-modulatory effects during acute experimental campylobacteriosis were addressed in the present study. Therefore, C. jejuni-challenged secondary abiotic IL-10-/- mice were treated perorally with either cumin-EO or placebo starting on day 2 post-infection. On day 6 post-infection, cumin-EO treated mice harbored lower ileal pathogen numbers and exhibited a better clinical outcome when compared to placebo controls. Furthermore, cumin-EO treatment alleviated enteropathogen-induced apoptotic cell responses in colonic epithelia. Whereas, on day 6 post-infection, a dampened secretion of pro-inflammatory mediators, including nitric oxide and IFN-γ to basal levels, could be assessed in mesenteric lymph nodes of cumin-EO treated mice, systemic MCP-1 concentrations were elevated in placebo counterparts only. In conclusion, our preclinical intervention study provides first evidence for promising immune-modulatory effects of cumin-EO in the combat of human campylobacteriosis. Future studies should address antimicrobial and immune-modulatory effects of natural compounds as adjunct antibiotics-independent treatment option for infectious diseases.

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26

Langfeld, Luis Q., Ke Du, Stefan Bereswill, and Markus M. Heimesaat. "A review of the antimicrobial and immune-modulatory properties of the gut microbiota-derived short chain fatty acid propionate – What is new?" European Journal of Microbiology and Immunology 11, no. 2 (July 10, 2021): 50–56. http://dx.doi.org/10.1556/1886.2021.00005.

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AbstractAs antimicrobial resistance poses a globally rising health problem, the identification of alternative antimicrobial agents is urgently required. The short chain fatty acid propionate which is physiologically produced by the gut microbiota constitutes a promising molecule given that it has been widely used as a cosmetics and food preservative due to its antimicrobial effects. This literature survey aims to determine the most recent state of knowledge about the antimicrobial and immune-modulatory properties of propionate. Both in vitro and in vivo studies published between 2011 and 2020 confirmed the ability of propionate to inhibit the growth of several cellular pathogens, including Gram-positive and Gram-negative multi-drug resistant bacteria and fungi. In addition, heterogenous immune-modulatory and in particular, anti-inflammatory effects of propionate could be assessed involving a diverse signaling network that needs further comprehension. In conclusion, our literature survey provides evidence that propionate displays a plethora of health-beneficial including antimicrobial and immune-modulatory effects. Future research is required to further unravel the underlying molecular mechanisms and to set the basis for in vivo infection and clinical studies to broaden the path of propionate as a promising adjunct antibiotics-independent option in the combat of infections caused by multi-drug resistant bacteria.

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Salem, Mohamed A., Nora M. Aborehab, Ahmed A. Al-Karmalawy, Alisdair R. Fernie, Saleh Alseekh, and Shahira M. Ezzat. "Potential Valorization of Edible Nuts By-Products: Exploring the Immune-Modulatory and Antioxidants Effects of Selected Nut Shells Extracts in Relation to Their Metabolic Profiles." Antioxidants 11, no. 3 (February 25, 2022): 462. http://dx.doi.org/10.3390/antiox11030462.

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The immune system is a potent army that defends our body against various infections and diseases through innate and adaptive immunity. Herbal medicine is one of the essential sources for enhancing immunity because of affordability, availability, minor side effects, and consumers’ preferences. Hazelnuts, walnuts, almonds, and peanuts are among the most widespread edible nuts that are rich in phenolics, fats, fibers, vitamins, proteins, and minerals. The potential of nut shells in phytoremediation has attracted increasing attention as a sustainable solution for waste recycling. Here, we determined the in vitro immune-modulatory activity as well as the metabolite profile of the four nut shell extracts. The addition of the extracts to LPS-stimulated macrophages, especially peanut and walnut shells, has downregulated the gene expression of AP-1, TNF-α, IL-8, iNOS, and COX-2 expression levels. Significant antioxidant capabilities and immune-modulatory effects have been traced for peanut shells. UPLC-MS metabolic profiling of the four nut shell extracts allowed the detection of a relatively high level of phenolic compounds in peanut shells. Intriguingly, a significant correlation between the antioxidant capacity and the total phenolic content was found, indicating the contribution of the phenolic compounds to the antioxidant properties and hence the immune-modulatory activity. Furthermore, molecular docking and structure–activity relationship (SAR) studies revealed kaempferol rutinoside and proanthocyanidin A5’ as potential iNOS inhibitors.

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28

Vos, A. P., L. M'Rabet, B. Stahl, G. Boehm, and Johan Garssen. "Immune-Modulatory Effects and Potential Working Mechanisms of Orally Applied Nondigestible Carbohydrates." Critical Reviews™ in Immunology 27, no. 2 (2007): 97–140. http://dx.doi.org/10.1615/critrevimmunol.v27.i2.10.

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Groh, L. A., D. Verel, C. D. C. C. Van Der Heijden, V. Matzaraki, S. J. C. F. M. Moorlag, L. C. De Bree, V. A. C. M. Koeken, et al. "Immune modulatory effects of progesterone on oxLDL-induced trained immunity in monocytes." Atherosclerosis 331 (August 2021): e80-e81. http://dx.doi.org/10.1016/j.atherosclerosis.2021.06.235.

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Elfaki, Mona E. E., Eltahir A. G. Khalil, Anne S. De Groot, Ahmed M. Musa, Andres Gutierrez, Brima M. Younis, Kawthar A. M. Salih, and Ahmed M. El-Hassan. "Immunogenicity and immune modulatory effects of in silico predictedL. donovanicandidate peptide vaccines." Human Vaccines & Immunotherapeutics 8, no. 12 (December 2012): 1769–74. http://dx.doi.org/10.4161/hv.21881.

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Severyanova, L., A. Konoplya, I. Bobyntsev, Yu Smahtin, and D. Plotnikov. "Modulatory effects of regulatory peptides on an immune response in stress condition." Pathophysiology 5 (June 1998): 160. http://dx.doi.org/10.1016/s0928-4680(98)80910-3.

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Göhner, Claudia, Justine S. Fitzgerald, Jolien Fledderus, Maja Weber, Ekkehard Schleußner, Udo R. Markert, Sicco A. Scherjon, Torsten Plösch, and Marijke M. Faas. "Immune-modulatory effects of syncytiotrophoblast extracellular vesicles during normal and preeclamptic pregnancy." Placenta 45 (September 2016): 133. http://dx.doi.org/10.1016/j.placenta.2016.06.249.

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Guang, Du, Ma Baoxia, Zhang Rui, and Sun Minghui. "Modulatory effects of compound polysaccharide Erweikang on the immune function of mice." Journal of Huazhong University of Science and Technology [Medical Sciences] 22, no. 3 (September 2002): 221–23. http://dx.doi.org/10.1007/bf02828185.

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Kara, Adem, Sumeyra Akman, Seckin Ozkanlar, Ummuhan Tozoglu, Yıldıray Kalkan, Cenk Fatih Canakci, and Sinan Tozoglu. "Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats." Free Radical Biology and Medicine 55 (February 2013): 21–26. http://dx.doi.org/10.1016/j.freeradbiomed.2012.11.002.

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Burbano, Catalina, Mauricio Rojas, Gloria Vásquez, and Diana Castaño. "Microparticles That Form Immune Complexes as Modulatory Structures in Autoimmune Responses." Mediators of Inflammation 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/267590.

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Microparticles (MPs) are induced during apoptosis, cell activation, and even “spontaneous” release. Initially MPs were considered to be inert cellular products with no biological function. However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs depend upon the cellular background and the mechanism inducing them. They possess a wide spectrum of biological effects on intercellular communication by transferring different molecules able to modulate other cells. MPs interact with their target cells through different mechanisms: membrane fusion, macropinocytosis, and receptor-mediated endocytosis. However, when MPs remain in the extracellular milieu, they undergo modifications such as citrullination, glycosylation, and partial proteolysis, among others, becoming a source of neoantigens. In rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), reports indicated elevated levels of MPs with different composition, content, and effects compared with those isolated from healthy individuals. MPs can also form immune complexes amplifying the proinflammatory response and tissue damage. Their early detection and characterization could facilitate an appropriate diagnosis optimizing the pharmacological strategies, in different diseases including cancer, infection, and autoimmunity. This review focuses on the current knowledge about MPs and their involvement in the immunopathogenesis of SLE and RA.

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Kumar, Vipin, Ayushi Mishra, and Anchal Singh. "Identification of promising nutraceuticals against filarial immune-modulatory proteins: insights from in silico and ex vivo studies." RSC Advances 12, no. 35 (2022): 22542–54. http://dx.doi.org/10.1039/d2ra03287b.

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Here in drug docking analysis, molecular dynamics simulations and ex vivo approaches were used to demonstrate the anti-filarial effects of nutraceuticals against immune modulatory proteins of lymphatic filarial parasites.

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Du, Ke, Stefan Bereswill, and Markus M. Heimesaat. "A literature survey on antimicrobial and immune-modulatory effects of butyrate revealing non-antibiotic approaches to tackle bacterial infections." European Journal of Microbiology and Immunology 11, no. 1 (March 30, 2021): 1–9. http://dx.doi.org/10.1556/1886.2021.00001.

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AbstractThe excessive prescription of antibiotics has led to an increasing number of antimicrobial resistances, posing a major public health concern. Therefore, the pharmacological research has shifted its focus to the identification of natural compounds that exhibit anti-pathogenic properties without triggering antibiotic resistance. Butyrate has received increasing attention as a promising candidate for the treatment of bacterial infections in the gastrointestinal tract, particularly when antibiotic treatment is contraindicated. This literature survey summarizes recently investigated antibacterial and immune-modulatory effects of butyrate. This survey revealed that butyrate exerts direct antimicrobial effects against distinct strains of Acinetobacter baumannii, Escherichia coli, Bacillus, and Staphylococcus species. In addition, in vitro and in vivo studies confirmed indirect antimicrobial effects of butyrate, which were exhibited via induction of host defensin production as well as by activation of innate and adaptive immune responses. Finally, the synergistic action of butyrate in combination with other antimicrobial compounds results in a striking clearance of bacterial pathogens. In conclusion, butyrate and its derivatives might be considered as promising antibacterial and immune-modulatory agents in order to tackle bacterial infections without antibiotics.

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Bereswill, Stefan, Soraya Mousavi, Dennis Weschka, and Markus M. Heimesaat. "Disease-Alleviating Effects of Peroral Activated Charcoal Treatment in Acute Murine Campylobacteriosis." Microorganisms 9, no. 7 (June 30, 2021): 1424. http://dx.doi.org/10.3390/microorganisms9071424.

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Foodborne Campylobacter jejuni infections are on the rise and responsible for worldwide serious health issues. Increasing resistance of C. jejuni strains against antimicrobial treatments, necessitates antibiotics-independent treatment options for acute campylobacteriosis. Activated charcoal (AC) constitutes a long-known and safe compound for the treatment of bacterial enteritis. In this preclinical intervention study, we addressed potential anti-pathogenic and immune-modulatory effects of AC during acute experimental campylobacteriosis. Therefore, microbiota-depleted IL-10−/− mice were infected with C. jejuni by gavage and challenged with either AC or placebo via the drinking water starting on day 2 post-infection. On day 6 post-infection, AC as compared to placebo-treated mice did not only harbor lower intestinal pathogen loads but also presented with alleviated C. jejuni-induced clinical signs such as diarrhea and wasting symptoms. The improved clinical outcome of AC-treated mice was accompanied by less colonic epithelial cell apoptosis and reduced pro-inflammatory immune responses in the intestinal tract. Notably, AC treatment did not only alleviate intestinal, but also extra-intestinal and systemic immune responses as indicated by dampened pro-inflammatory mediator secretion. Given the anti-pathogenic and immune-modulatory properties of AC in this study, a short-term application of this non-toxic drug constitutes a promising antibiotics-independent option for the treatment of human campylobacteriosis.

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Furnish, Robin, Heather Bear, Xin Wei, and Timothy Phoenix. "MODL-29. EVALUATING TUMOR-IMMUNE INTERACTIONS IN MOUSE MODELS OF DIFFUSE INTRINSIC PONTINE GLIOMA." Neuro-Oncology 22, Supplement_3 (December 1, 2020): iii417. http://dx.doi.org/10.1093/neuonc/noaa222.602.

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Abstract BACKGROUND While adult gliomas show some level of immune cell infiltration, diffuse intrinsic pontine glioma (DIPG) is characterized as having an “immune cold” state. We have developed new immunocompetent mouse models of DIPG. These models faithfully recapitulate the pathological hallmarks of DIPG and provides a unique platform to investigate immune modulatory therapies and potential therapeutic benefits of check point inhibitor combination therapies. METHODS To evaluate the effects of CDK4/6 inhibition (CDK4/6i) on cell proliferation and immune interactions we performed a series of in vitro and in vivo studies using DIPG mouse models. In vitro assays included dose response curves, transcriptional profiling, and MHC1 expression. In vivo preclinical studies treated mouse models with CDK4/6i with or without immune check-point inhibitors (ICI). We also examined other candidate immune modulatory therapies in vitro. RESULTS CDK4/6i (Abemeciclib) reduced proliferation of DIPG cells derived from mouse models, and displayed a modest increase in immune activation by MHC1 expression and transcriptome. Pilot in vivo preclinical studies did not show any significant changes in DIPG proliferation or immune changes with CDK4/6i treatment, ICI treatment, or the combination of CDK4/6i + ICI. In vitro testing of other immune-modulatory drugs identified additional candidates that can be tested in vivo. CONCLUSION CDK4/6i displayed in vitro action, but lacked efficacy in DIPG mouse models in vivo. Further use of spontaneous DIPG mouse models will provide a rapid preclinical platform to evaluate in vivo tumor-immune interactions, drug efficacy, and mechanisms of resistance.

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Hooi, Doreen S. W., Barrie W. Bycroft, Siri Ram Chhabra, Paul Williams, and David I. Pritchard. "Differential Immune Modulatory Activity of Pseudomonas aeruginosa Quorum-Sensing Signal Molecules." Infection and Immunity 72, no. 11 (November 2004): 6463–70. http://dx.doi.org/10.1128/iai.72.11.6463-6470.2004.

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ABSTRACT Pseudomonas aeruginosa releases a spectrum of well-regulated virulence factors, controlled by intercellular communication (quorum sensing) and mediated through the production of small diffusible quorum-sensing signal molecules (QSSM). We hypothesize that QSSM may in fact serve a dual purpose, also allowing bacterial colonization via their intrinsic immune-modulatory capacity. One class of signal molecule, the N-acylhomoserine lactones, has pleiotropic effects on eukaryotic cells, particularly those involved in host immunity. In the present study, we have determined the comparative effects of two chemically distinct and endobronchially detectable QSSM, N-(3-oxododecanoyl)-l-homoserine lactone (3-oxo-C12-HSL) and 2-heptyl-3-hydroxy-4 (1H)-quinolone or the Pseudomonas quinolone signal (PQS), on human leukocytes exposed to a series of stimuli designed to detect differential immunological activity in vitro. 3-Oxo-C12-HSL and PQS displayed differential effects on the release of interleukin-2 (IL-2) when human T cells were activated via the T-cell receptor and CD28 (a costimulatory molecule). 3-Oxo-C12-HSL inhibited cell proliferation and IL-2 release; PQS inhibited cell proliferation without affecting IL-2 release. Both molecules inhibited cell proliferation and the release of IL-2 following mitogen stimulation. Furthermore, in the presence of Escherichia coli lipopolysaccharide, 3-oxo-C12-HSL inhibited tumor necrosis factor alpha release from human monocytes, as reported previously (K. Tateda et al., Infect. Immun. 64:37-43, 1996), whereas PQS did not inhibit in this assay. These data highlight the presence of two differentially active immune modulatory QSSM from P. aeruginosa, which are detectable endobronchially and may be active at the host/pathogen interface during infection with P. aeruginosa, should the bronchial airway lymphoid tissues prove to be accessible to QSSM.

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Papait, Andrea, Elsa Vertua, Marta Magatti, Sabrina Ceccariglia, Silvia De Munari, Antonietta Rosa Silini, Michal Sheleg, Racheli Ofir, and Ornella Parolini. "Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine." Cells 9, no. 1 (January 6, 2020): 127. http://dx.doi.org/10.3390/cells9010127.

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Placenta-derived mesenchymal stromal cells (MSC) have attracted more attention for their immune modulatory properties and poor immunogenicity, which makes them suitable for allogeneic transplantation. Although MSC isolated from different areas of the placenta share several features, they also present significant biological differences, which might point to distinct clinical applications. Hence, we compared cells from full term placenta distinguishing them on the basis of their origin, either maternal or fetal. We used cells developed by Pluristem LTD: PLacenta expanded mesenchymal-like adherent stromal cells (PLX), maternal-derived cells (PLX-PAD), fetal-derived cells (PLX-R18), and amniotic membrane-derived MSC (hAMSC). We compared immune modulatory properties evaluating effects on T-lymphocyte proliferation, expression of cytotoxicity markers, T-helper and T-regulatory cell polarization, and monocyte differentiation toward antigen presenting cells (APC). Furthermore, we investigated cell immunogenicity. We show that MSCs and MSC-like cells from both fetal and maternal sources present immune modulatory properties versus lymphoid (T cells) and myeloid (APC) cells, whereby fetal-derived cells (PLX-R18 and hAMSC) have a stronger capacity to modulate immune cell proliferation and differentiation. Our results emphasize the importance of understanding the cell origin and characteristics in order to obtain a desired result, such as modulation of the inflammatory response that is critical in fostering regenerative processes.

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Matsushita, Maiko, and Mai Kawaguchi. "Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy." Journal of Oncology 2018 (October 25, 2018): 1–7. http://dx.doi.org/10.1155/2018/8653489.

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Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or adoptive T cell therapies, have contributed to better outcomes in cancer patients. However, there are still many cancers with no cure. Therefore, combinations of several treatment strategies are being explored, and enhancing anticancer immunity will play an important role to combat the disease. There have been several reports on the immune-modulatory effects of commonly used drugs, namely, statin, metformin, and angiotensin receptor blockers (ARBs), which suggest that these drugs could enhance immunity against cancer cells. Other anticancer drugs, such as anthracyclines, thalidomides, lenalidomides, and hypomethylating drugs, could also strengthen the immune system to attack cancer cells at a relatively low dose. Hence, these drugs might contribute to better outcomes in cancer patients.

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Morales-Lopez, R., and J. Brufau. "Immune-modulatory effects of dietarySaccharomyces cerevisiaecell wall in broiler chickens inoculated withEscherichia colilipopolysaccharide." British Poultry Science 54, no. 2 (April 2013): 247–51. http://dx.doi.org/10.1080/00071668.2013.782386.

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Mathew, James M., Manuel Carreno, Laphalle Fuller, Camillo Ricordi, Andreas Tzakis, Violet Esquenazi, and Joshua Miller. "MODULATORY EFFECTS OF HUMAN DONOR BONE MARROW CELLS ON ALLOGENEIC CELLULAR IMMUNE RESPONSES1." Transplantation 63, no. 5 (March 1997): 686–92. http://dx.doi.org/10.1097/00007890-199703150-00013.

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Souza-Moreira, L., K. Schlosser, Y. Tan, M. Salkhordeh, I. Watpool, J. Wang, L. McIntyre, D. J. Stewart, and S. H. Mei. "Effects of inflammatory cytokines on the immune-modulatory properties of Mesenchymal Stem Cell." Cytotherapy 20, no. 5 (May 2018): S51. http://dx.doi.org/10.1016/j.jcyt.2018.02.138.

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Däubener, Walter, Susanne Nockemann, Marc Gutsche та Ulrich Hadding. "Heparin inhibits the antiparasitic and immune modulatory effects of human recombinant interferon-γ". European Journal of Immunology 25, № 3 (березень 1995): 688–92. http://dx.doi.org/10.1002/eji.1830250309.

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Wu, Sheng-Hua, Dimitris P. Kelefiotis, and Elias A. Lianos. "Modulatory effects of eicosanoids on mesangial cell growth in response to immune injury." Immunopharmacology 28, no. 2 (September 1994): 125–36. http://dx.doi.org/10.1016/0162-3109(94)90028-0.

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Dorhoi, A., V. Dobrean, M. Zăhan, and P. Virag. "Modulatory effects of several herbal extracts on avian peripheral blood cell immune responses." Phytotherapy Research 20, no. 5 (2006): 352–58. http://dx.doi.org/10.1002/ptr.1859.

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DEHLINK, ELEONORA, KONRAD J. DOMIG, CHRISTINE LOIBICHLER, ELKE KAMPL, THOMAS EIWEGGER, APOSTOLOS GEORGOPOULOS, WOLFGANG KNEIFEL, RADVAN URBANEK, and ZSOLT SZÉPFALUSI. "Heat- and Formalin-Inactivated Probiotic Bacteria Induce Comparable Cytokine Patterns in Intestinal Epithelial Cell–Leucocyte Cocultures." Journal of Food Protection 70, no. 10 (October 1, 2007): 2417–21. http://dx.doi.org/10.4315/0362-028x-70.10.2417.

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The mode of inactivation of probiotic bacteria may profoundly affect their immune-modulatory properties to the point of reversal of effects in in vitro human intestinal epithelial-like cell cultures (Caco-2). To further investigate the influence of inactivation treatment on cytokine production, three probiotic strains were evaluated—live, heat-inactivated, and formalininactivated strains—for their impact on interleukin (IL) 6, IL-8, and IL-10 production in Caco-2–leucocyte cocultures. The tested bacteria induced strain-specific production of IL-6, IL-8, and IL-10. No suppressive effects on cytokine synthesis were observed. Live microorganisms seemed to be slightly more potent inducers of cytokine production than nonviable strains, but differences to inactivated bacteria were not statistically significant. Our results indicate that heat and formalin treatments of probiotic microorganisms are equivalent inactivation methods in terms of induction of IL-6, IL-8, and IL-10 production in Caco-2–peripheral blood mononuclear cell cocultures and do not invert immune-modulatory effects.

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Kamiya, Takeshi, Michiko Shikano, Mamoru Tanaka, Keiji Ozeki, Masahide Ebi, Takahito Katano, Shingo Hamano, et al. "Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/828137.

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Background. Recently, it was revealed that low grade mucosal inflammation and/or immune imbalance of the lower digestive tract is one of the mechanisms involved in symptom generation in patients with irritable bowel syndrome (IBS). Biobran, arabinoxylan compound derived from rice bran, has been reported to have several biological actions such as anti-inflammatory and immune modulatory effects. So we investigated the therapeutic effects of Biobran in patients with IBS.Method. Forty patients with diarrhea predominant or mixed type IBS were randomly assigned to either a Biobran group for treatment with Biobran or a placebo group. Therapeutic efficacy and IBS symptoms were assessed subjectively by the patients after 4 weeks of administration.Results. The global assessment was effective in 63.2% of the Biobran group and in 30% of the placebo group (P<0.05, Biobran group versus placebo group). Biobran group showed a significant decrease in the score of diarrhea and constipation and in CRP value. However, no significant changes were observed in the placebo group.Conclusion. The administration of Biobran improved IBS symptoms. It is likely that anti-inflammatory and/or immune modulatory effects of Biobran might be useful in IBS patients.

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