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Дисертації з теми "Immunogenetics"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Middleton, D. "Histocompatibility and immunogenetics." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368778.

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2

Fanning, Gregory Charles. "Immunogenetics of systemic sclerosis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284535.

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3

Thomson, W. "Immunogenetics of rheumatoid arthritis." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383908.

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4

Saini, Surinder Singh. "Molecular immunogenetics of bovine antibody." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0005/NQ40388.pdf.

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5

Anderson, Amy Elizabeth. "The immunogenetics of Helicobacter infection." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414822.

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6

Ghosh, Soumitra. "Immunogenetics of Type I diabetes." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306514.

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7

Else, Kathryn J. "Immunogenetics of Trichuris muris infection." Thesis, University of Nottingham, 1989. http://eprints.nottingham.ac.uk/12875/.

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Анотація:

Investigations have been made into the genetic control of immunity to the nematode Trichuris muris. Both background genes and genes within the mouse major histocompatibility complex (MHC), H-2, were shown to influence the expulsion of T. muris with the former having the stronger influence. At least two genes within the H-2 complex determined response phenotypes, the effects of "resistance" or "susceptibility" alleles at I-A being modulated by resistance or susceptibility alleles at aD end locus/loci. Differential responsiveness within slowly responding mouse strains suggested that parasite-dep

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8

Tozatto, Maio Karina. "Immunogenetics in sickle cell disease." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCC093.

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La drépanocytose est l’hémoglobinopathie héréditaire la plus fréquente, causée par un polymorphisme unique d’un nucléotide (SNP) dans le gène de la beta-globine (HBB). Ce SNP détermine la synthèse de l’hémoglobine S, qui polymérise lorsqu’elle est soumise au stress, et ceci change la forme des hématies drépanocytaires en faucille. Les drépanocytes sont moins déformables, plus adhérents à l’endothélium, et plus susceptibles à l’hémolyse. Les complications cliniques de la drépanocytose peuvent être expliquées par l’interaction entre la vaso-occlusion, l’hémolyse et l’activation inflammatoire rés

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9

Jeffery, Katherine Joanna Mary. "The immunogenetics of HTLV-I infection." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392152.

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10

Goodman, Reyna Suzanne. "Immunogenetics of haematopoietic stem cell transplantation." Thesis, Anglia Ruskin University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478885.

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11

Mullighan, Charles Grenfell. "The immunogenetics of common variable immunodeficiency /." Title page, table of contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09MD/09mdm959.pdf.

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12

Foley, Bree Amanda. "The immunogenetics of natural killer cell alloreactivity." University of Western Australia. School of Pathology and Laboratory Medicine, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0242.

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Анотація:

[Truncated abstract] Natural killer (NK) cell alloreactivity can be exploited in haploidentical haematopoietic stem cell transplantation (HSCT) to improve graft survival, reduce graft versus host disease and decrease leukaemic relapse. NK cells lyse cells that have reduced expression of class I HLA molecules. In an allogeneic setting, donor NK cells may be activated by the absence of donor (self) class I HLA molecules on recipient cells; the absence of self-epitopes being detected by inhibitory KIR receptors on donor NK cells. The way in which genetic polymorphism of the receptors and ligands

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13

Weissert, Robert. "Immunogenetics and treatment of experimental autoimmune encephalomyelitis /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3645-5/.

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14

Hodgkinson, Andrea Dawn. "Immunogenetics of type 1 diabetes in man." Thesis, University of Plymouth, 1999. http://hdl.handle.net/10026.1/1994.

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Анотація:

Genetic susceptibility to type 1 diabetes is associated with the major histocompatibility complex (MHC) on human chromosome 6. To analyse the contribution of the class I region of the MHC to disease susceptibility, polymorphism of the class Ib molecule HLA-E and several genetic markers within the region was investigated in 378 British Caucasoid patients with type 1 diabetes as defined by the National Diabetes Group, 100 multiplex families from the BDA Warren Repository and 216 unselected normal British Caucasoid controls. PCR-Sequence-Specific Oligonucleotide Probing (PCR-SSOP) was used to ana

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15

Caws, Maxine Anna Maria. "The diagnosis and immunogenetics of tuberculous meningitis." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271415.

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16

Castro, Prieto Aines del Carmen. "Immunogenetics of free-ranging felids on Namibian farmlands." Phd thesis, Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5550/.

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Анотація:

Genetic variation is crucial for the long-term survival of the species as it provides the potential for adaptive responses to environmental changes such as emerging diseases. The Major Histocompatibility Complex (MHC) is a gene family that plays a central role in the vertebrate’s immune system by triggering the adaptive immune response after exposure to pathogens. MHC genes have become highly suitable molecular markers of adaptive significance. They synthesize two primary cell surface molecules namely MHC class I and class II that recognize short fragments of proteins derived respectively from

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17

Wahid, Faisal Numman. "Immunogenetics of Heligmosomoides polygyrus (Nematospiroides dubius) in mice." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280098.

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18

Soutter, Francesca. "Canine leishmaniosis : immunogenetics of response to infection and vaccination." Thesis, Royal Veterinary College (University of London), 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701667.

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19

Graus, Ivo Maria Franciscus. "Experimental autoimmune myasthenia gravis target organ resistance and immunogenetics /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=6512.

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20

Sargent, Carole A. "Molecular mapping of the HLA Class III region." Thesis, University of Oxford, 1988. https://ora.ox.ac.uk/objects/uuid:b208c37f-e2d2-4ad1-a90f-524bff86c17a.

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(a) The class III region of the human MHC is approximately 1.1 Mbp in size. Almost 50% has been cloned in two overlapping cosmid clusters by chromosome walking from the complement/ 210H gene cluster and from the TNF a locus. The complement/ 210H cosmid cluster consists of 45 independent recombinants, spaning 390 kb. The TNFα and TNF β cosmid cluster consists of 16 independent recombinants, spanning 150 kb. Each genomic insert has been characterised by restriction enzyme digestion and Southern blot analysis to produce a detailed restriction map of the cloned region. (b) Single copy D

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21

Basson, Michiel Albertus. "The interaction of HLA Class I molecules with the murine T cell repertoire." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243059.

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22

Bradbury, Andrew Raymon Morton. "The mouse equivalent of the human thymic antigen CD1." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330154.

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23

Anderson, Michael J. "Molecular genetics of the human complement protein C4." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.256362.

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24

Ore, Begona Aguado. "Sequence analysis and functional characterisation of three novel genes located in the human major histocompatibility complex." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390471.

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25

Lewis, Jonathan William. "The assembly of class I MHC molecules in the endoplasmic reticulum." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298558.

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26

Foster, Linda S. "Antigen presentation to cytotoxic T cells." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279882.

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27

Chandler, Phillip Richard. "The identification of human minor histocompability antigens." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239604.

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28

Palmer, Donald Balfour. "The chromatin structure of the mouse beta-2-microglobulin locus." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293770.

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29

Goff, Lindsey Kate. "Cluster of differentiation 45 isoforms and murine thymic ontogeny." Thesis, Open University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333266.

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30

Fairchild, Susan Patricia. "Endogenous superantigens and T-cell repertoire selection." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359244.

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31

Rajp, Amit. "The immunogenetics of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273729.

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32

Sage, Deborah Anne. "HLA-DP immunogenetics and significance in allogeneic bone marrow transplantation." Thesis, University of Portsmouth, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308955.

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33

Wong, Florence Susan. "A study of the immunogenetics of type 1 diabetes mellitus." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309474.

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34

Contini, Silvia <1976&gt. "Immunogenetics of granulomatous lung disease: A phenotypic approach to susceptibility." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1765/1/TESI_Silvia_Contini_dott.pdf.

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35

Contini, Silvia <1976&gt. "Immunogenetics of granulomatous lung disease: A phenotypic approach to susceptibility." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1765/.

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36

Huang, Xiufeng. "Immunogenetics of acute anterior uveitis and comparison to ankylosing spondylitis." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/213839/1/Xiufeng_Huang_Thesis.pdf.

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This thesis comprehensively applies genome-wide association study, Mendelian randomization analyses, and cytokine proteomics to investigate the genetic basis and immunopathogenic mechanisms of acute anterior uveitis (AAU). Multiple susceptibility loci, environmental risk factors, and potential biomarkers are identified, and a polygenic risk score for AAU developed. These findings provide novel insights into the immunogenetics in AAU, and contribute to clinical translational studies.

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37

Conforti, Valéria Amorim. "CpG motif-based adjuvant enhances immunogenicity of a recombinant LHRH vaccine and noninvasive monitoring of adrenal and gonadal function in the jaguar (Panthera onca)." Online access for everyone, 2007. http://www.dissertations.wsu.edu/Dissertations/Spring2007/V_Conforti_051507.pdf.

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38

De, Cassan Simone. "Towards improved blood-stage malaria vaccines : characterising the underlying immunogenicity of vaccine adjuvants and vectors." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711629.

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39

Brittain, Katherine Patricia. "Genetic and genomic diversity of crocodylians: applications in evolution and immunogenetics." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29800.

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Анотація:

There are ~27 recognised extant species of crocodylians (Crocodylia), which inhabit a large range of tropical, fresh- or saltwater ecosystems around the world. Crocodylians appear to have an effective immune system that allows them to cope with a variety of pathogenic challenges. Crocodylians have been shown to live with a range of opportunistic infections, and yet wild animals seldom display disease symptoms. Also, reptile immune systems are less well studied than their mammalian and avian counterparts, and yet reptiles hold a unique evolutionary position as cold-blooded amniotes. Studying th

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40

DREUSSI, EVA. "Pharmacogenomics of miRNA for personalized anticancer treatment." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908099.

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Pharmacogenetics (PGx) aims at the definition of predictive and prognostic genetic biomarkers that can help clinicians in treatment tailoring. In this thesis, we explored two emerging topics in PGx: SNPs affecting the activity and maturation of a class of non coding RNAs, microRNAs (miRNAs), and immunogenetics. Genetic analyses were performed by a medium throughput technology, Veracode technology (Illumina). The clinical model of this study is represented by the locally advanced rectal cancer (LARC). Specifically, the main two aims of this study were: 1. the identification of predictive bioma

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41

Deonarain, Raj Kumarie. "Targeted disruption and insertion of a reporter gene in the interferon beta locus in mice." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322319.

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42

Davies, Jessica Lesley. "Functional immunogenomics in multiple sclerosis." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709188.

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43

Zeng, Chenjie. "Study of calreticulin mediated NY-ESO-1 immunogenicity in human dendritic cells /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202008%20ZENG.

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44

Juffs, Helen Gwendolyn. "Immunogenicity of B-cell chronic lymphocytic leukemia and prospects for immunotherapy /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16312.pdf.

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45

Jahromi, Mohamed Mirza. "A study of the molecular immunogenetics of type 1 diabetes in man." Thesis, University of Plymouth, 2000. http://hdl.handle.net/10026.1/2583.

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Type 1 diabetes is caused by immune destruction of pancreatic β cells. There is increasing evidence that genes outside the MHC region contribute to the pathogenesis of type 1 diabetes. Cytokines due to their role in immune regulation seem to play a crucial role in the pathogenesis of the disease. Three hundred and eight patients with type 1 diabetes and 150 normal controls were genotyped for polymorphism in the genes for IFN-γ, IL-4, IL-6, and TGF-β1. All assays employed in this study were PCR based. The IFN-γ CA repeats was an octa-allelic repeat and the 3 / 3 genotype showed a significant as

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46

Turner, Andrew. "Immunogenetics and polymorphism in a natural population of field voles (Microtus agrestis)." Thesis, University of Liverpool, 2010. http://livrepository.liverpool.ac.uk/1468/.

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Most of our understanding of immunity has been gained through studies of humans or laboratory rodents. However, such studies do not allow the immune system to be studied in the ecological context in which it has evolved and, as such, they provide a poor model for studying the variation in infectious disease resistance and immune function observed in natural settings. Studies of natural populations have provided fresh insights into the evolution and phenotypic consequences of immunogenetic variation, but have thus far concentrated almost exclusively on genes of the major histocompatibility comp

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47

SANNA, MARCO. "Biology and Immunogenetics of Immune Effectors: Applications in Hematology and Cell Therapy." Doctoral thesis, Università degli Studi di Cagliari, 2018. http://hdl.handle.net/11584/255997.

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Immune effectors are the cells responsible for host response to cancer cells and germs. There is a stringent need to understand immune effectors biology to improve infectious disease management, particularly for patients affected by deep grade immunosuppression. During my research, I chose to investigate the role of Glucose-6-Phosphate Dehydrogenase (G6PD) on immune effectors biology, to evaluate its relevance for response to infectious agents. G6PD is a key enzyme of pentose-phosphate pathway, producing reducing power in the form of NADPH, that is essential for oxidative stress protection mac

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48

Schulte, Kathleen Q. "Mutagenized HLA DNA Constructs: Tools for Validating Molecular HLA Typing Methodologies." Thesis, University of North Texas, 1999. https://digital.library.unt.edu/ark:/67531/metadc500888/.

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This study describes the development and validation of mutagenized cloned DNA constructs, which correspond to the polymorphic regions of the class II region of the HLA complex. The constructs were used to verify the allelic specificity of primers and probes in polymerase chain reaction (PCR)-based HLA typing assays such as Sequence Specific Primers (SSP) and Sequence Specific Oligonucleotide Probes (SSOP). The constructs consisted of the entire polymorphic region of exon 2 of class II HLA allele sequences that included primer annealing sites or probe hybridization sites. An HLA allele sequence

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49

Zhou, Jie. "Genetic polymorphisms of type I interferon receptor 1 affect the susceptibility to chronic HBV infection association analysis and mechanistic investigation /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38722951.

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50

Davenport, Miles Philip. "Molecular analysis of HLA associations with infectious disease." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297073.

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