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1

Salinas, Sara, and Yannick Simonin. "Les atteintes neurologiques liées au SARS-CoV-2 et autres coronavirus humains." médecine/sciences 36, no. 8-9 (August 2020): 775–82. http://dx.doi.org/10.1051/medsci/2020122.

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L’émergence récente d’un nouveau coronavirus, le SARS-CoV-2, responsable de la maladie appelée COVID-19, est un nouvel avertissement du risque pour la santé publique représenté par les zoonoses virales et notamment par les coronavirus. Principalement connus pour leur capacité à infecter les voies respiratoires supérieures et inférieures, les coronavirus peuvent également affecter le système nerveux central et périphérique, comme c’est le cas pour de nombreux virus respiratoires, tels que les virus influenza ou le virus respiratoire syncytial. Les infections du système nerveux sont un problème important de santé publique car elles peuvent provoquer des atteintes dévastatrices allant jusqu’au décès du patient, en particulier lorsqu’elles surviennent chez les personnes fragilisées ou âgées plus sensibles à ce type d’infection. Les connaissances de la physiopathologie des infections par les coronavirus émergents (MERS-CoV, SARS-CoV et SARS-CoV-2) et leurs moyens d’accéder au système nerveux central sont, pour l’heure, très sommaires. Les travaux en cours visent notamment à mieux appréhender les mécanismes associés aux atteintes neurologiques observées. Dans cette revue nous aborderons l’état des connaissances actuelles sur le neurotropisme des coronavirus humains et les mécanismes associés en développant tout particulièrement les dernières données concernant le SARS-CoV-2.
2

Petat, Hortense, Vincent Gajdos, François Angoulvant, Pierre-Olivier Vidalain, Sandrine Corbet, Christophe Marguet, Jacques Brouard, Astrid Vabret, and Meriadeg Ar Gouilh. "High Frequency of Viral Co-Detections in Acute Bronchiolitis." Viruses 13, no. 6 (May 26, 2021): 990. http://dx.doi.org/10.3390/v13060990.

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Over two years (2012–2014), 719 nasopharyngeal samples were collected from 6-week- to 12-month-old infants presenting at the emergency department with moderate to severe acute bronchiolitis. Viral testing was performed, and we found that 98% of samples were positive, including 90% for respiratory syncytial virus, 34% for human rhino virus, and 55% for viral co-detections, with a predominance of RSV/HRV co-infections (30%). Interestingly, we found that the risk of being infected by HRV is higher in the absence of RSV, suggesting interferences or exclusion mechanisms between these two viruses. Conversely, coronavirus infection had no impact on the likelihood of co-infection involving HRV and RSV. Bronchiolitis is the leading cause of hospitalizations in infants before 12 months of age, and many questions about its role in later chronic respiratory diseases (asthma and chronic obstructive pulmonary disease) exist. The role of virus detection and the burden of viral codetections need to be further explored, in order to understand the physiopathology of chronic respiratory diseases, a major public health issue.
3

Jamard, Simon, Tristan Ferry, and Florent Valour. "Physiopathologie des infections ostéoarticulaires." Revue du Rhumatisme Monographies 89, no. 1 (February 2022): 3–10. http://dx.doi.org/10.1016/j.monrhu.2021.10.002.

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4

Caron, F. "Physiopathologie des infections urinaires nosocomiales." Médecine et Maladies Infectieuses 33, no. 9 (September 2003): 438–46. http://dx.doi.org/10.1016/s0399-077x(03)00148-3.

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5

Betsou, F., and N. Guiso. "Physiopathologie des infections à Bordetella." Médecine et Maladies Infectieuses 25 (January 1995): 1230–32. http://dx.doi.org/10.1016/s0399-077x(05)81672-5.

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6

Orfila, J. "Physiopathologie des infections génitales hautes." Médecine et Maladies Infectieuses 24, no. 4 (April 1994): 361–68. http://dx.doi.org/10.1016/s0399-077x(05)80433-0.

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7

Guiso, N. "Physiopathologie des infections à Bordetella." Archives de Pédiatrie 2, no. 12 (December 1995): 1226. http://dx.doi.org/10.1016/0929-693x(95)90060-g.

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8

Berche, P. "Physiopathologie des infections à Listeria monocytogenes." Médecine et Maladies Infectieuses 25 (February 1995): 197–209. http://dx.doi.org/10.1016/s0399-077x(05)81057-1.

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9

Ader, Florence, and Louis Bernard. "Physiopathologie des infections sur matériel orthopédique." La Presse Médicale 34, no. 7 (April 2005): 533–36. http://dx.doi.org/10.1016/s0755-4982(05)83967-3.

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10

Barbosa, Adriana Aparecida de Oliveira, Gabriel Cunha Beato, Pietra Antônia Filiol Belin, and Larissa Ramos Araújo. "ASPECTOS CLÍNICOS DA MÁ NUTRIÇÃO NA COVID-19." Simbio-Logias Revista Eletrônica de Educação Filosofia e Nutrição 12, no. 16 (2020): 01–19. http://dx.doi.org/10.32905/19833253.2020.12.16p01.

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The pandemic caused by the new coronavirus has sparked discussions among health professionals about the role of food and nutrition in the infectious condition caused by the SARS-CoV-2 virus in different population groups. Malnutrition, including obesity, may reflect more severe outcomes in the physiopathology of infection and systemic responses caused by COVID-19. The present work aims to make considerations directed to the nutritionist about the susceptibility of COVID-19 in individuals submitted to malnutrition, highlighting possible outcomes of the disease and the importance of nutritional care in maintaining the health of these patients. Therefore, maintaining a good nutritional status of these patients, combined with an adequate level of micronutrients will not guarantee protection against infection caused by COVID-19, however, it is essential to minimize the risks of worsening this disease.
11

Berche, P. "Physiopathologie des infections neuroméningées à Listeria monocytogenes." Médecine et Maladies Infectieuses 15, no. 10 (October 1985): 588–92. http://dx.doi.org/10.1016/s0399-077x(85)80018-4.

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12

Cespedes, Mateus da Silveira, and José Carlos Rosa Pires de Souza. "Coronavirus: a clinical update of Covid-19." Revista da Associação Médica Brasileira 66, no. 2 (February 2020): 116–23. http://dx.doi.org/10.1590/1806-9282.66.2.116.

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SUMMARY INTRODUCTION A covid-19 pandemic decreed by WHO has raised greater awareness of it. EPIDEMIOLOGY The infection reached the mark of 350,000 patients in 33 countries and affected as comorbidities the presence of comorbidities and advanced age. TRANSMISSIBILITY The transmissibility calculated so far is similar to the H1N1 epidemic, but with lower mortality rates. PHYSIOPATHOLOGY The SARS-CoV-2 virus, of the Coronaviridae family, has the capacity for cellular invasion through the angiotensin-converting enzyme 2 does not have a lower respiratory epithelium and in the cells of the small intestine mucosa. CLINICAL MANIFESTATIONS a presentation can be divided into mild (fever, fatigue, cough, myalgia, and sputum) and severe (cyanosis, dyspnoea, tachypnea, chest pain, hypoxemia and need for clinical measurement) and has an estimated estimate of 2%. DIAGNOSIS allows the detection of viral load in CRP-TR of patients with high clinical suspicion. TREATMENT based on supportive measures and infection control. In severe cases, the use of medications such as hydroxychloroquine and azithromycin or medication can be promising. Take care to avoid the use of corticosteroids. There are no restrictions on the use of resources and ACEIs / ARBs.
13

Ghislain Aubin, Guillaume, and Stéphane Corvec. "Épidémiologie et physiopathologie générale des infections ostéo-articulaires." Revue Francophone des Laboratoires 2016, no. 480 (March 2016): 25–31. http://dx.doi.org/10.1016/s1773-035x(16)30084-3.

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14

Pavese, P. "Infections urinaires nosocomiales : définition, diagnostic, physiopathologie, prévention, traitement." Médecine et Maladies Infectieuses 33 (September 2003): 266–74. http://dx.doi.org/10.1016/s0399-077x(03)00159-8.

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15

Alonso, J. M. "Immunité et physiopathologie des infections de l’arbre respiratoire." Médecine et Maladies Infectieuses 38, no. 8 (August 2008): 433–37. http://dx.doi.org/10.1016/j.medmal.2008.06.013.

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16

Lagrange, Ph H. "Infections par Streptococcus pneumoniae : physiopathologie et réponses immunitaires." Médecine et Maladies Infectieuses 24 (October 1994): 927–38. http://dx.doi.org/10.1016/s0399-077x(05)80769-3.

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17

Bébéar, C. M. "Physiopathologie et diagnostic des infections à Mycoplasma pneumoniae." Revue Française d'Allergologie et d'Immunologie Clinique 47, no. 7 (November 2007): 438–41. http://dx.doi.org/10.1016/j.allerg.2007.08.004.

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18

Taha, M. K., and J. M. Alonso. "Physiopathologie et pathogénie moléculaire des infections méningococciques invasives." Archives de Pédiatrie 12, no. 6 (June 2005): 753–54. http://dx.doi.org/10.1016/j.arcped.2005.04.026.

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19

Bébéar, C. M. "Physiopathologie et diagnostic des infections à Mycoplasma pneumoniae." Archives de Pédiatrie 15, no. 7 (July 2008): 1253–56. http://dx.doi.org/10.1016/j.arcped.2008.02.010.

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20

Eggimann, P., and D. Pittet. "Physiopathologie et prévention des infections liées aux accès vasculaires." Médecine et Maladies Infectieuses 33, no. 11 (November 2003): 554–63. http://dx.doi.org/10.1016/s0399-077x(03)00238-5.

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21

Nitenberg, Gérard, Jean-Luc Jagot, and Sami Antoun. "Physiopathologie et épidémiologie des infections liées aux cathéters veineux centraux." Nutrition Clinique et Métabolisme 5, no. 1 (January 1991): 11–24. http://dx.doi.org/10.1016/s0985-0562(05)80024-x.

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22

Senneville, E., and V. Baclet. "Physiopathologie et traitement curatif des infections à méningocoque : aspects actuels." Pathologie Biologie 50, no. 10 (December 2002): 613–19. http://dx.doi.org/10.1016/s0369-8114(02)00362-0.

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23

Judlin, P. G., and O. Thiebaugeorges. "Physiopathologie, diagnostic et prise en charge des infections génitales hautes." Gynécologie Obstétrique & Fertilité 37, no. 2 (February 2009): 172–82. http://dx.doi.org/10.1016/j.gyobfe.2008.12.005.

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24

Greenberg, Stephen. "Rhinovirus and Coronavirus Infections." Seminars in Respiratory and Critical Care Medicine 28, no. 2 (April 2007): 182–92. http://dx.doi.org/10.1055/s-2007-976490.

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25

Shafiekhani, Mojtaba, Anahita Dehghani, Mina Shahisavandi, Seyed Ali Nabavizadeh, Maryam Kabiri, Amir Hossein Hassani, and Abdolreza Haghpanah. "Pharmacotherapeutic approach toward urological medications and vaccination during COVID-19: a narrative review." Therapeutic Advances in Urology 13 (January 2021): 175628722110467. http://dx.doi.org/10.1177/17562872211046794.

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One year after the prevalence of the novel coronavirus pandemic, some aspects of the physiopathology, treatment and progression of coronavirus 2019 disease (COVID-19) have remained unknown. Since no comprehensive study on the use of urological medications in patients with COVID-19 has been carried out, this narrative review aimed to focus on clinically important issues about the treatment of COVID-19 and urologic medications regarding efficacy, modifications, side effects and interactions in different urologic diseases. In this review, we provide information about the pharmacotherapeutic approach toward urologic medications in patients with COVID-19 infection. This study provides an overview of medications in benign prostatic hyperplasia, prostate cancer, impotence and sexual dysfunction, urolithiasis, kidney transplantation and hypertension as the most frequent diseases in which the patients are on long-term medications. Also, the effect of urologic drugs on the efficacy of vaccination is briefly discussed.
26

Grimprel, E., and R. Cohen. "Épidémiologie et physiopathologie des infections ostéoarticulaires chez l'enfant (nouveau-né exclu)." Archives de Pédiatrie 14 (October 2007): S81—S85. http://dx.doi.org/10.1016/s0929-693x(07)80039-x.

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27

Léone, M., S. Arnaud, C. Boisson, M. C. Blanc-Bimar, and C. Martin. "Infections urinaires nosocomiales sur sonde en réanimation : physiopathologie, épidémiologie et prophylaxie." Annales Françaises d'Anesthésie et de Réanimation 19, no. 1 (January 2000): 23–34. http://dx.doi.org/10.1016/s0750-7658(00)00127-1.

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28

Bhattacharyya, Sayan, Amit Banik, and Atul Raj. "Novel Coronavirus infections: a review." IP International Journal of Medical Microbiology and Tropical Diseases 6, no. 2 (July 15, 2020): 83–85. http://dx.doi.org/10.18231/j.ijmmtd.2020.017.

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29

Kin, Nathalie, and Astrid Vabret. "Les infections à coronavirus humains." Revue Francophone des Laboratoires 2016, no. 487 (December 2016): 25–33. http://dx.doi.org/10.1016/s1773-035x(16)30369-0.

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30

Asadi-Pooya, Ali A. "Seizures associated with coronavirus infections." Seizure 79 (July 2020): 49–52. http://dx.doi.org/10.1016/j.seizure.2020.05.005.

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31

Nath, Avindra. "Neurologic complications of coronavirus infections." Neurology 94, no. 19 (March 30, 2020): 809–10. http://dx.doi.org/10.1212/wnl.0000000000009455.

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32

Belikova, Yu A., Yu V. Samsonov, and E. V. Abakushina. "Modern vaccines and coronavirus infections." Research and Practical Medicine Journal 7, no. 4 (December 22, 2020): 135–54. http://dx.doi.org/10.17709/2409-2231-2020-7-4-11.

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33

Li, Geng, Yaohua Fan, Yanni Lai, Tiantian Han, Zonghui Li, Peiwen Zhou, Pan Pan, et al. "Coronavirus infections and immune responses." Journal of Medical Virology 92, no. 4 (February 7, 2020): 424–32. http://dx.doi.org/10.1002/jmv.25685.

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34

Sizun, Jacques, Arnaud Gagneur, C. Legrand, and M. Raoul Baron. "RESPIRATORY CORONAVIRUS INFECTIONS IN CHILDREN." Pediatric Infectious Disease Journal 20, no. 5 (May 2001): 555. http://dx.doi.org/10.1097/00006454-200105000-00026.

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35

Galang, Romeo R., Karen Chang, Penelope Strid, Margaret Christine Snead, Kate R. Woodworth, Lawrence D. House, Mirna Perez, et al. "Severe Coronavirus Infections in Pregnancy." Obstetrics & Gynecology 136, no. 2 (June 15, 2020): 262–72. http://dx.doi.org/10.1097/aog.0000000000004011.

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36

Wege, Helmut. "Immunopathological aspects of coronavirus infections." Springer Seminars in Immunopathology 17, no. 2-3 (September 1995): 133–48. http://dx.doi.org/10.1007/bf00196162.

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37

Neroev, V. V., T. N. Kiseleva, and E. K. Eliseeva. "Ophthalmological aspects of coronavirus infections." Russian Ophthalmological Journal 14, no. 1 (March 20, 2021): 7–14. http://dx.doi.org/10.21516/2072-0076-2021-14-1-7-14.

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Анотація:
The novel coronavirus infection (COVID-19) caused by SARS-CоV-2 virus, may lead to ocular diseases besides affecting the respiratory system. Cororonavirus infection may be transmitted not only through the respiratory system but also through the conjunctiva. The review article summarizes the data on the origin and variants of coronaviruses that infect humans, as well as on SARS-CоV-2 structures. Literature data on prospects of molecular diagnostics of the disease, coronavirus type detection methods, clinical sample types and duration of the disease before it is diagnosed are discussed. The data on the relationship between the coronavirus infection and conjunctivitis are given. Molecular tests of the tear and conjunctival swabs were used to diagnose the coronavirus infection independently of whether symptoms of ocular disorders were present. The real-time reverse-transcription of RNA polymerase chain reaction (PCR) was the most informative method for diagnosis of SARS-CоV-2 in the early stage of COVID-19 (until the 9th day). The presence of SARS-CоV-2 in the tear fluid and conjunctival swabs indicates the need for safety measures to prevent virus transmission through the ocular surface, including protective goggles to be worn by healthcare workers. Since side effects in the eye may appear, COVID-19 patients with visual impairment who received etiotropic or pathogenetic treatment are advised to consult an ophthalmologist.
38

Gaujac, Cristiano, and Regiane Cristina Amaral. "Neurological manifestations and pathophysiological mechanisms of Covid-19." ARCHIVES OF HEALTH INVESTIGATION 10, no. 7 (July 16, 2021): 1040–47. http://dx.doi.org/10.21270/archi.v10i7.5460.

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Background - Severe acute respiratory syndrome coronavirus-2 is a novel, highly infectious coronavirus and the etiologic agent of Covid-19. The course of Covid-19 can range from mild flu-like symptoms to severe, life-threatening symptoms, especially when comorbidities are present. Increasing studies have reinforced the association between SARS-CoV-2 and various neurological manifestations, although the pathophysiological mechanisms remain uncertain. Objective - The aim of this paper was to briefly describe current findings on the relationship between SARS-CoV-2 pathophysiology and major CNS and Peripheral Nervous System (PNS) manifestations. Methods and Material - This work consists of a literature review based on the study of academic papers. To this end, the Pubmed platform was used to search for scientific articles, using the keywords: covid-19, coronavirus, physiopathology, neuronal symptoms. Results - out of 114,660 articles found, 94 were selected for this review. Conclusions - Periodic reviews collaborate in the constant updating and summarization of findings. Understanding the pathophysiology of SARS-CoV-2 on the SN and the link between the systems may lead to earlier and earlier diagnoses of neurological involvement, guide therapeutic management, prevent sequelae, and preserve lives.
39

Lau, S. K. P., P. C. Y. Woo, C. C. Y. Yip, H. Tse, H. w. Tsoi, V. C. C. Cheng, P. Lee, et al. "Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong." Journal of Clinical Microbiology 44, no. 6 (June 1, 2006): 2063–71. http://dx.doi.org/10.1128/jcm.02614-05.

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40

Mimoz, O., F. Rayeh, and B. Debaene. "Infections liées aux cathéters veineux en réanimation. Physiopathologie, diagnostic, traitement et prévention." Annales Françaises d'Anesthésie et de Réanimation 20, no. 6 (June 2001): 520–36. http://dx.doi.org/10.1016/s0750-7658(01)00411-7.

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41

Trouillet-Assant, Sophie, Marlène Gallet, Pauline Nauroy, Sacha Flammier, Sébastien Lustig, Jean-Philippe Rasigade, Tristan Ferry, François Vandenesch, Pierre Jurdic, and Frédéric Laurent. "Physiopathologie des infections ostéo-articulaires à Staphylococcus aureus – interactions ostéoclastes – S. aureus." Revue de Chirurgie Orthopédique et Traumatologique 100, no. 7 (November 2014): S317—S318. http://dx.doi.org/10.1016/j.rcot.2014.09.260.

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42

Schumacher-Perdreau, Françoise, and Georg Peters. "Physiopathologie des infections à Staphylocoques à coagulase négative dues aux cathéters intravasculaires." Nutrition Clinique et Métabolisme 5, no. 1 (January 1991): 25–28. http://dx.doi.org/10.1016/s0985-0562(05)80025-1.

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43

Principi, Nicola, Samantha Bosis, and Susanna Esposito. "Effects of Coronavirus Infections in Children." Emerging Infectious Diseases 16, no. 2 (February 2010): 183–88. http://dx.doi.org/10.3201/eid1602.090469.

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44

Gralinski, Lisa E., and Ralph S. Baric. "Molecular pathology of emerging coronavirus infections." Journal of Pathology 235, no. 2 (December 11, 2014): 185–95. http://dx.doi.org/10.1002/path.4454.

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45

Greenberg, Stephen. "Update on Rhinovirus and Coronavirus Infections." Seminars in Respiratory and Critical Care Medicine 32, no. 04 (August 2011): 433–46. http://dx.doi.org/10.1055/s-0031-1283283.

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46

Flamenbaum, Matthew, and Jesse Roman. "Endemic and Emerging Coronavirus Pulmonary Infections." American Journal of the Medical Sciences 360, no. 6 (December 2020): 728–32. http://dx.doi.org/10.1016/j.amjms.2020.06.013.

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47

Dhefer, Iqbal Hanash. "Liver damage during infections with coronavirus." Journal of Techniques 3, no. 2 (June 30, 2021): 79–85. http://dx.doi.org/10.51173/jt.v3i2.302.

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Анотація:
The pathogen of the new 2019 coronavirus disease (COVID-19), the sever acute respiratory syndrome coronavirus 2 (SARS-Cov-2), presented a significant risk to health care. The WHO has described the SARS-CoV-2 infection outbreak as an international public health emergency. The main damage caused by the infection with SARS-CoV-2 was known to be lung infections. Previous research revealed that liver damage is prevalent in patients infected with the additional widely zoonotic coronaviruses, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), and has been reviewed in relation to the severity of MERS, SARS, and COVID-19 diseases. Likewise, the mechanism and features of liver damage and liver injury has also been observed, as outlined in this review, which results in extreme cases during the phases of the disease.
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Geppe, N. A., O. I. Afanasyeva, A. L. Zaplatnikov, and E. G. Kondyurina. "Coronavirus infection in children." Voprosy praktičeskoj pediatrii 15, no. 5 (2020): 73–86. http://dx.doi.org/10.20953/1817-7646-2020-5-73-86.

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This literature review aims to provide an update on the problem of coronavirus infection in children. It covers specific features of the pathogens and ways of their transmission in children and focuses on the nuances of the clinical course. It also describes the approaches to diagnosis, treatment, and prevention of seasonal coronavirus infections and COVID-19. Particular attention is paid to treatment and prevention of acute respiratory viral infections (ARVIs), including seasonal coronavirus infections, during the ongoing COVID-19 pandemic using Anaferon for children, a drug with an immune-mediated antiviral effect. The article provides the data on experimental and clinical evaluation of Anaferon efficacy in children with coronavirus infections. Experimental in vitro studies of Anaferon for children demonstrated its antiviral efficacy against highly pathogenic MERS-CoV. Clinical trials, including double-blind placebo-controlled RCTs, showed that the inclusion of Anaferon for children in the comprehensive therapy of seasonal coronavirus infections reduced the disease duration, mitigated symptoms, and decreased the incidence of nosocomial infections. These effects were associated with the modulating activity of Anaferon for children affecting both cellular and humoral immunity. The analysis of studies evaluating Anaferon for children allows us to recommend this drug for widespread use in the treatment and prevention of seasonal ARVIs, including those caused by coronaviruses during the ongoing COVID-19 pandemic. Key words: Anaferon for children, treatment, coronavirus infection, prevention, COVID-19
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Tangudu, Chandra, Heidi Olivares, Jason Netland, Stanley Perlman, and Thomas Gallagher. "Severe Acute Respiratory Syndrome Coronavirus Protein 6 Accelerates Murine Coronavirus Infections." Journal of Virology 81, no. 3 (November 15, 2006): 1220–29. http://dx.doi.org/10.1128/jvi.01515-06.

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ABSTRACT One or more of the unique 3′-proximal open reading frames (ORFs) of the severe acute respiratory syndrome (SARS) coronavirus may encode determinants of virus virulence. A prime candidate is ORF6, which encodes a 63-amino-acid membrane-associated peptide that can dramatically increase the lethality of an otherwise attenuated JHM strain of murine coronavirus (L. Pewe, H. Zhou, J. Netland, C. Tangudu, H. Olivares, L. Shi, D. Look, T. Gallagher, and S. Perlman, J. Virol. 79:11335-11342, 2005). To discern virulence mechanisms, we compared the in vitro growth properties of rJ.6, a recombinant JHM expressing the SARS peptide, with isogenic rJ.6-KO, which has an inactive ORF containing a mutated initiation codon and a termination codon at internal position 27. The rJ.6 infections proceeded rapidly, secreting progeny about 1.5 h earlier than rJ.6-KO infections did. The rJ.6 infections were also set apart by early viral protein accumulation and by robust expansion via syncytia, a characteristic feature of JHM virus dissemination. We found no evidence for protein 6 operating at the virus entry or assembly stage, as virions from either infection were indistinguishable. Rather, protein 6 appeared to operate by fostering viral RNA and protein synthesis, as RNA quantifications by reverse transcription-quantitative PCR revealed viral RNA levels in the rJ.6 cultures that were five to eight times higher than those lacking protein 6. Furthermore, protein 6 coimmunoprecipitated with viral RNAs and colocalized on cytoplasmic vesicles with replicating viral RNAs. The SARS coronavirus encodes a novel membrane protein 6 that can accelerate replication of a related mouse virus, a property that may explain its ability to increase in vivo virus virulence.
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Zhao, Shan, Wentao Li, Nancy Schuurman, Frank van Kuppeveld, Berend-Jan Bosch, and Herman Egberink. "Serological Screening for Coronavirus Infections in Cats." Viruses 11, no. 8 (August 13, 2019): 743. http://dx.doi.org/10.3390/v11080743.

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Coronaviruses (CoVs) are widespread among mammals and birds and known for their potential for cross-species transmission. In cats, infections with feline coronaviruses (FCoVs) are common. Several non-feline coronaviruses have been reported to infect feline cells as well as cats after experimental infection, supported by their ability to engage the feline receptor ortholog for cell entry. However, whether cats might become naturally infected with CoVs of other species is unknown. We analyzed coronavirus infections in cats by serological monitoring. In total 137 cat serum samples and 25 FCoV type 1 or type 2-specific antisera were screened for the presence of antibodies against the S1 receptor binding subunit of the CoV spike protein, which is immunogenic and possesses low amino acid sequence identity among coronavirus species. Seventy-eight sera were positive for antibodies that recognized one or more coronavirus S1s whereas 1 serum exclusively reacted with human coronavirus 229E (HCoV-229E) and two sera exclusively reacted with porcine delta coronavirus (PDCoV). We observed antigenic cross-reactivity between S1s of type 1 and type 2 FCoVs, and between FCoV type 1 and porcine epidemic diarrhea virus (PEDV). Domain mapping of antibody epitopes indicated the presence of conserved epitope(s) particularly in the CD domains of S1. The cross-reactivity of FCoV type 1 and PEDV was also observed at the level of virus neutralization. To conclude, we provide the first evidence of antigenic cross-reactivity among S1 proteins of coronaviruses, which should be considered in the development of serological diagnoses. In addition, the potential role of cats in cross-species transmission of coronaviruses cannot be excluded.

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