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Дисертації з теми "Insilico"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Sharma, Anurag. "An Insilico Design of Nanoclay Based Nanocomposites and Scaffolds In Bone Tissue Engineering." Diss., North Dakota State University, 2016. http://hdl.handle.net/10365/25907.

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Анотація:

A multiscale in silico approach to design polymer nanocomposites and scaffolds for bone tissue engineering applications is described in this study. This study focuses on the role of biomaterials design and selection, structural integrity and mechanical properties evolution during degradation and tissue regeneration in the successful design of polymer nanocomposite scaffolds. Polymer nanocomposite scaffolds are synthesized using aminoacid modified montmorillonite nanoclay with biomineralized hydroxyapatite and polycaprolactone (PCL/in situ HAPclay). Representative molecular models of polymer na

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2

Buhry, Laure. "Estimation de paramètres de modèles de neurones biologiques sur une plate-forme de SNN (Spiking Neural Network) implantés "insilico"." Thesis, Bordeaux 1, 2010. http://www.theses.fr/2010BOR14057/document.

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Ces travaux de thèse, réalisés dans une équipe concevant des circuits analogiques neuromimétiques suivant le modèle d’Hodgkin-Huxley, concernent la modélisation de neurones biologiques, plus précisément, l’estimation des paramètres de modèles de neurones. Une première partie de ce manuscrit s’attache à faire le lien entre la modélisation neuronale et l’optimisation. L’accent est mis sur le modèle d’Hodgkin- Huxley pour lequel il existait déjà une méthode d’extraction des paramètres associée à une technique de mesures électrophysiologiques (le voltage-clamp) mais dont les approximations success

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3

Dade, Sébastien. "Identification insilico et validation expérimentale de gènes spécifiquement exprimés dans l'ovocyte de mammifères : les MATER-like et les oogénésines." Tours, 2006. http://www.theses.fr/2006TOUR4002.

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Grâce à l'augmentation exponentielle des séquences disponibles dans les banques de données d'une part et le développement de logiciels permettant leur analyse d'autre part, nous avons généré in silico une liste de gènes candidats potentiellement spécifiques de l'ovocyte. Ceci a pu se faire grâce à l'utilisation d'un outil de soustraction de banques d'EST depuis le site du NCBI (http:/www. Ncbi. Nlm. Nih. Gov/), le Digital Differential Display (DDD). Ces gènes candidats ont fait l'objet l'études expérimentales pour un certain nombre d'entre eux, notamment des gènes simulaires à NALP5/MATER et d

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4

Kolluri, Satya Krishna Prasanna. "Evaluation of performance of MSI detection tools using targeted sequencing data." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453793.

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In recent years, digitalization and computer-based technologies have greatly revolutionized the field of bioinformatics. Advance research and development of computer-based programs have enhanced various DNA sequencing technologies. This advancement has significantly broadened our understanding of genomic evolution and has widely contributed to the application of clinical genomics. Cancer has been one of the major causes of death across the world. Cancer is mainly caused due to the damage or changes in DNA that affect the function of genes which contain a set of instructions that control variou

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5

BATISTA, Lucr?cia de Mascarenhas. "Vozes do insilio: o Movimiento Cristiano de Liberaci?n entre dissid?ncia e oposi??o em Cuba (1988-2002)." Universidade Federal Rural do Rio de Janeiro, 2013. https://tede.ufrrj.br/jspui/handle/jspui/2262.

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Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2018-04-27T17:54:24Z No. of bitstreams: 1 2013 - Lucr?cia de Mascarenhas Batista.pdf: 512428 bytes, checksum: 2e16fcd0fec935501ab5399e313e6468 (MD5)<br>Made available in DSpace on 2018-04-27T17:54:24Z (GMT). No. of bitstreams: 1 2013 - Lucr?cia de Mascarenhas Batista.pdf: 512428 bytes, checksum: 2e16fcd0fec935501ab5399e313e6468 (MD5) Previous issue date: 2013-02-22<br>CAPES<br>This work intents to discuss the relationship between the left-wing sets and the opposition regarding the historical experience of h ?Movimiento Cristiano de Libe

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6

Capellari, Alberto. "Analisi lineare e non lineare di silos spiralati in acciaio per il contenimento di materiali sciolti." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amslaurea.unibo.it/1501/.

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7

RIGGIO, VINCENZO ANDREA. "Valutazione di produzione di biogas da prove sperimentali di digestione anaerobica da differenti mix di scarti da biomassa agricola." Doctoral thesis, Politecnico di Torino, 2010. http://hdl.handle.net/11583/2500106.

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Nella sperimentazione si sono valutati alcuni aspetti tecnici e tecnologici relativi alla produzione di energia, in forma di biogas, ottenuta dalla digestione anaerobica di scarti provenienti principalmente da produzioni agricole – zootecniche. Questa tecnica è ben nota e utilizzata da diversi anni, ma a fronte di un crescente interesse da parte delle autorità locali, contrappone una certa stazionarietà nella risoluzione dei principali problemi che la accompagnano. Agendo su un territorio locale che fa dell’agricoltura, e della zootecnia, uno dei comparti produttivi maggiormente soggetto a ris

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8

Nayak, Santosh Kumar, and Kiran Soy Murum. "Insilico Annotation of Un-characterized proteins of Mycobacterium Tuberculosis." Thesis, 2011. http://ethesis.nitrkl.ac.in/2372/1/107bt009.pdf.

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Mycobacterium tuberculosis (MTB) is a pathogenic bacteria species in the genus Mycobacterium and the causative agent of most cases of tuberculosis. The genome of the H37Rv strain was published in 1998. Its size is 4 million base pairs, with 3959 genes; 40% of these genes have had their function characterised, with possible function postulated for another 44%. Within the genome are also 6 pseudo genes. The genome contains 250 genes involved in fatty acid metabolism, with 39 of these involved in the polyketide metabolism generating the waxy coat. Such large numbers of conserved genes show the ev

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9

Tewari, Aparna. "Insilico design and evaluation of hybrid Hsp 90 inhibitors for cancer therapy." Thesis, 2014. http://ethesis.nitrkl.ac.in/6413/1/E-89.pdf.

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Breast Cancer has become the second most common threat to the people all over the world. Inhibiting Hsp90 has been considered to be an excellent therapeutic approach in breast cancer where the diseased proteins are directed towards proteasomal degradation pathway. However apart from the inhibitors strong binding to Hsp90, they leave other kinds of disadvantages like solubility, and toxicity problems. In our present investigation, we have developed number of hybrid inhibitor molecules using existing Hsp90-inhibitors to achieve a higher binding potential as well as minimal toxic properties. Thus

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10

Singh, Ajeet. "Identification of Drug Target Against Bacteroides Fragilis 638R: Through Insilico Genome Analysis." Thesis, 2015. http://ethesis.nitrkl.ac.in/7910/1/627.pdf.

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Bacteroides fragilis is a Gram-negative, rod shaped bacterium and the most standard anaerobic bacterium creating bacteremia in people. It is a part of the normal endogenous flora in human body and is normally commensal, but can cause infection if displaced into the bloodstream or surrounding tissue following trauma, surgery or disease. In this approach we have found certain target protein which can give rise to novel drug for the B.fragilis disease 638R. All the metabolic pathways which are present in the pathogen but not present in the human are taken as unique metabolic pathways. Here there

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11

Kazavali, Shaik. "Design of Novel Hsp90 Inhibitors to Trigger Tau Degradation in Alzheimer’s disease: An Insilico Approach." Thesis, 2014. http://ethesis.nitrkl.ac.in/6032/1/110BT0549-20.pdf.

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Alzheimer’s disease (AD) is one of the most common Protein amyloid-associated Neurodegenerative disorder which is an irreversible and progressive patterns of cognitive and functional impairments. The neuropathological identifications and findings of AD includes presence of plaques and neurofibrillary tangles.Tau hypothesis is a model of neurofibrillary tangles where, hyper phosphorylated tau begins to misfold with other threads of tau. Ultimately, they lead to form neurofibrillary tangles in nerve cells. This involves in the disruption of microtubules, and eventually leads to breaking down of

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12

Das, Om Bikash Kumar. "Identification of a Novel Drug Target Protein Against Haemophilus Influenzae Rd KW20: An Insilico Approach." Thesis, 2015. http://ethesis.nitrkl.ac.in/7908/1/626.pdf.

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Haemophilus Influenzae (H. Influenzae) is the gram negative bacteria causes infection at respiratory tract in human. Rd KW20 strain is mostly responsible for this disease. According to WHO statistics it kills 386,000 child per year in all over the world. In this approach we have identified some drug target protein which can be used as novel drug against this deadly pathogen. The metabolic pathways which are absent in the human but present in H. Influenza are taken as unique metabolic pathways. Here there are four such unique pathways are present only in case of bacteria, but not available in h

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13

Gangadhar, Vidya. "Role Of Idiotypic Anti-Idiotypic Network In The Sustenance Of Immunological Memory." Thesis, 2007. https://etd.iisc.ac.in/handle/2005/516.

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Анотація:

Living amidst a milieu of pathogenic organisms, vertebrates are in constant threat of contracting one or the other disease. As a mechanism of protection against such ‘invasions’, the vertebrate immune system has evolved to serve two main functions. One, to generate a specific immune response against the invading pathogen (in the from of specific antibodies and cell mediated immune responses). And two, to ‘remember’ the pathogen after the first exposure and mount a heightened and quicker immune response upon subsequent encounters. This phenomenon is called immunological memory, or anamnestic re

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14

Gangadhar, Vidya. "Role Of Idiotypic Anti-Idiotypic Network In The Sustenance Of Immunological Memory." Thesis, 2007. http://hdl.handle.net/2005/516.

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Анотація:

Living amidst a milieu of pathogenic organisms, vertebrates are in constant threat of contracting one or the other disease. As a mechanism of protection against such ‘invasions’, the vertebrate immune system has evolved to serve two main functions. One, to generate a specific immune response against the invading pathogen (in the from of specific antibodies and cell mediated immune responses). And two, to ‘remember’ the pathogen after the first exposure and mount a heightened and quicker immune response upon subsequent encounters. This phenomenon is called immunological memory, or anamnestic re

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15

Wu, Tsung-Han, and 吳宗翰. "Analysis and Application of Microlens Array inSilicon Packaging." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/14967070543670995308.

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碩士<br>國立臺灣大學<br>光電工程學研究所<br>96<br>Light-emitting Diode (LED) is a suitable light source in general lighting and backlight module due to its robustness, long life, and low power consumption. For high brightness LED, packaging has become a crucial factor. The issue of packaging can be divided into optical design and thermal management. External efficiency and uniformity of optical design will be discussed in this thesis. To increase external efficiency and uniformity in single chip LED, we introduce microlens array. The characteristic of microlens is discussed through experiment and simulation

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