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Добірка наукової літератури з теми "Insulin carrier"

Автор: Grafiati

Опубліковано: 10 січня 2023

Оновлено: 28 січня 2023

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Статті в журналах з теми "Insulin carrier"

1

Mohsin, Mahmoud A., Yousef Haik, and Tahir Abdulrehman. "Glucose-Mediated Insulin Release Carrier." Polymer Science, Series A 60, no. 5 (September 2018): 618–27. http://dx.doi.org/10.1134/s0965545x18050097.

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2

Ostróżka-Cieślik, Aneta, and Barbara Dolińska. "Hydrogel as a Transdermal Insulin Carrier." Metabolism 116 (March 2021): 154604. http://dx.doi.org/10.1016/j.metabol.2020.154604.

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3

Wei, Wei, Lian-Yan Wang, Jie Wu, and Guang-Hui Ma. "Quaternized chitosan microspheres as insulin carrier." Journal of Biotechnology 136 (October 2008): S452. http://dx.doi.org/10.1016/j.jbiotec.2008.07.1050.

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4

Rušavý, Zdenek, Vladimir Sramek, Renata Sucha, Silvie Lacigova, and Ondrej Topolcan. "Effects of Carrier Solution on Insulin Bioavailability." Journal of Parenteral and Enteral Nutrition 28, no. 6 (November 2004): 439–41. http://dx.doi.org/10.1177/0148607104028006439.

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5

Nguyen, Vu Viet Linh, and Dai Phu Huynh. "THE ELECTROSPRAYED INSULIN-LOADED POLYCAPROLACTONE MICROPARTICLES AS A DRUG CARRIER." ASEAN Engineering Journal 12, no. 2 (June 1, 2022): 63–68. http://dx.doi.org/10.11113/aej.v12.16910.

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Drug and protein encapsulated polymeric microparticles have been considered as the most effective delivery in pharmaceutical biotechnology. In this work, we report the fabrication of polycaprolactone microparticles (PCL MPs) containing insulin via an electrospraying method. The morphology, chemical composition, physicochemical properties, insulin encapsulation and release efficiency, degradation of PCL MPs, and cytotoxicity are systematically characterized and analyzed. The results indicate that insulin do not incorporate with PCL matrix leading to the deformation of PCL MPs’ structure. In addition, insulin can be loaded into the PCL MPs with high concentration up to 25 % while it remains chemical properties when releasing from the PCL MPs. Moreover, insulin demonstrates high burst release within the first day, subsequently the release become more stable during 2-7 days. The 80% viability of the cell suggests that PCL MPs are biocompartible to cells. As a consequence, the above mentioned material is proved to be has high potential for insulin carrier in controlled release application

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6

Obermaier-Kusser, B., C. Mühlbacher, J. Mushack, E. Seffer, B. Ermel, F. Machicao, F. Schmidt, and H. U. Häring. "Further evidence for a two-step model of glucose-transport regulation. Inositol phosphate-oligosaccharides regulate glucose-carrier activity." Biochemical Journal 261, no. 3 (August 1, 1989): 699–705. http://dx.doi.org/10.1042/bj2610699.

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The insulin effect on glucose uptake is not sufficiently explained by a simple glucose-carrier translocation model. Recent studies rather suggest a two-step model of carrier translocation and carrier activation. We used several pharmacological tools to characterize the proposed model further. We found that inositol phosphate (IP)-oligosaccharides isolated from the drug Actovegin, as well as the alkaloid vinblastine, show a partial insulin-like effect on glucose-transport activity of fat-cells (3-O-methylglucose uptake, expressed as % of equilibrium value per 4 s: basal 5.8%, insulin 59%, IP-oligosaccharides 30%, vinblastine 29%) without inducing carrier translocation. On the other hand, two newly developed anti-diabetic compounds (alpha-activated carbonic acids, BM 130795 and BM 13907) induced carrier translocation to the same extent as insulin and phorbol esters [cytochalasin-B-binding sites in plasma membranes: basal 5 pmol/mg of protein, insulin 13 pmol/mg of protein, TPA (12-O-tetradecanoylphorbol 13-acetate) 11.8 pmol/mg of protein, BM 130795 10.8 pmol/mg of protein], but produce also only 40-50% of the insulin effect on glucose-transport activity (basal 5.8%, insulin 59%, TPA 23%, BM 130795 35%). Almost the full insulin effect was mimicked by a combination of phorbol esters and IP-oligosaccharides (basal 7%, insulin 50%, IP-oligosaccharides 30%, TPA 23%, IP-oligosaccharides + TPA 45%). None of these substances stimulated insulin-receptor kinase in vitro or in vivo, suggesting a post-kinase site of action. The data confirm the following aspects of the proposed model: (1) carrier translocation and carrier activation are two independently regulated processes; (2) the full insulin effect is mimicked only by a simultaneous stimulation of carrier translocation and intrinsic carrier activity, suggesting that insulin acts through a synergism of both mechanisms; (3) IP-oligosaccharides might be involved in the transmission of a stimulatory signal on carrier activity.

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7

Valuev, L. I., I. L. Valuev, L. V. Vanchugova, and I. V. Obydennova. "Modified Hydrogel as a Carrier of Oral Insulin." Applied Biochemistry and Microbiology 57, no. 3 (May 2021): 373–76. http://dx.doi.org/10.1134/s0003683821020186.

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8

Rusavý, Z., V. Srámek, R. Suchá, E. Langhamerová, R. Rokyta, and O. Topolcan. "Impact of carrier solution on biological insulin availability." Critical Care 4, Suppl 1 (2000): P166. http://dx.doi.org/10.1186/cc886.

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9

Wang, Yuanpeng, Mian Fu, Zuwei Wang, X. X. Zhu, Ying Guan, and Yongjun Zhang. "A sustained zero-order release carrier for long-acting, peakless basal insulin therapy." Journal of Materials Chemistry B 8, no. 9 (2020): 1952–59. http://dx.doi.org/10.1039/c9tb02728a.

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10

Bahar, Adeleh, Zahra Kashi, Mehrnoush Sohrab, Mehrnoush Kowsarian, Ghasem Janbabaei, and Ardeshir Ghavamzadeh. "Relationship of Being a Beta Globin Gene Carrier with Insulin Resistance." Blood 118, no. 21 (November 18, 2011): 5305. http://dx.doi.org/10.1182/blood.v118.21.5305.5305.

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Abstract Abstract 5305 Objective: There was a paper in favor of beta-globin gene carrier and insulin resistance. Considering the high prevalence of these individuals in north of Iran, the present study was designed to assess the relationship between a beta-globin gene carrier and developing insulin resistance. Methods: This historical cohort study was conducted on 164 people, including 82 healthy controls and 82 individuals with thalassemia minor. The two study groups were matched for age, body mass index(BMI) and family history of diabetes mellitus. Blood samples were taken for; CBC, fasting blood sugar(FBS), liver enzymes (AST, ALT), high sensitive C- reactive protein(CRP), serum insulin and a standard OGTT were performed in all. Insulin resistance was diagnosed based on homeostasis model assessment method(HOMA). TM was diagnosed if microcytic(MCV<80 fl) hypochromia(MCH<25 pg) was detected on CBC and HbA2 ≥3.5% using HPLC method. Controls had negative past medical history and normal CBC. Student T- Test and and Chi-Square test were used to compare demographic data. Relative Risk was measured to test the hypothesis. P<0.05 was considered as significant. Results: Age, gender, BMI, were similar. CRP, and AST were significantly higher in case group. (p value <0.05). The Relative Risk for diabetes mellitus and insulin resistance in the cases with minor thalassemia was 2 (CI % 95:1.8–2.5) and 2.02 (CI % 95:1.7–2.4), respectively. Conclusion: The risk of developing diabetes and insulin resistance in patients with thalassemia minor is two times greater than the general population. Considering the high serum levels of CRP in these cases, the inflammation noted in liver cells could be considered as the underlying cause of insulin resistance, impaired glucose tolerance and diabetes in these patients. Disclosures: No relevant conflicts of interest to declare.

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Дисертації з теми "Insulin carrier"

1

Chen, Bin, and 陈斌. "Structural and functional characterization of human APPL2, a novel adaptor protein involved in insulin signaling." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4552757X.

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2

Cheng, King-yip. "APPL1 as a novel signaling mediator of adiponectin and insulin molecular mechanisms and physiological implications /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42182177.

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3

Zhu, Weidong, and 朱伟东. "APPL1 and APPL2: a pair of adaptor proteins as "yin-and-yang" regulators of insulin signaling in skeletalmuscle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45980470.

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4

Cheng, King-yip, and 鄭競業. "APPL1 as a novel signaling mediator of adiponectin and insulin: molecular mechanisms and physiologicalimplications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42182177.

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5

Guhmann, Pauline. "Délivrance orale d'insuline par double encapsulation : développement et évaluation de l'efficacité et de la sécurité des systèmes entériques et nanoparticulaires." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01071851.

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Actuellement, l'injection sous-cutanée d'insuline est le seul moyen pour les diabétiques de type 1 d'équilibrer leur glycémie. Les travaux de thèse entrent dans le cadre du projet ORAIL qui vise à développer un système de délivrance orale d'insuline basé sur la double encapsulation, et à valider l'efficacité et la sécurité de ce système in vitro dans des modèles d'épithélium intestinal, et in vivo chez le rat. Le vecteur pharmaceutique développé est composé d'une gélule contenant des nanoparticules (NPs) d'insuline formulées à partir d'acide (lactique-co-glycolique) par la méthode de double émulsion eau/huile/eau. Un premier objectif de la thèse a été d'évaluer chez le rat la gastrorésistance et l'entérosolubilité de la gélule sélectionnée pour l'encapsulation des NPs, par tomodensitométrie aux rayons X et par l'étude de la biodisponibilité de l'ibuprofène et de l'acétaminophène. Les résultats de ces travaux ont montré que la gélule est résistante en conditions gastriques et se dégrade au niveau de l'intestin. Un deuxième objectif a été de synthétiser des NPs d'insuline de taille croissante (100 à 800 nm), et d'évaluer l'internalisation de ces NPs et leur sécurité dans des cultures de cellules Caco-2, et dans des co-cultures de cellules Caco-2 et HT29-MTX. Les résultats de ces travaux ont montré que les NPs sont internalisées de manière dose et temps-dépendante, et que la taille de NPs permettant une internalisation optimale est de 400 nm après 4h d'incubation. Des études mécanistiques ont suggéré l'implication de mécanismes cavéoline-dépendants dans l'internalisation des NPs. Aucune toxicité des NPs n'a été observée quels que soient les paramètres étudiés (viabilité et mort cellulaire, augmentation de perméabilité, production de mucus, sécrétion de cytokines pro-inflammatoires). Dans une dernière partie de notre travail, nous avons montré que l'administration intraduodénale de NPs d'insuline de 200 et 400 nm à des rats diabétiques permettait une diminution significative de leur glycémie sans altération morphologique de leur paroi intestinale, données confortant nos résultats in vitro. Notre vecteur basé sur la double encapsulation semble donc être un système prometteur pour l'administration orale d'insuline. Le vecteur complet doit cependant être évalué in vivo chez le rat.

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6

Hagan, G. Nana. "Adipocyte Insulin-Mediated Glucose Transport: The Role of Myosin 1c, and a Method for in vivo Investigation: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/403.

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The importance of insulin delivery and action is best characterized in Type 2 Diabetes, a disease that is becoming a pandemic both nationally and globally. Obesity is a principal risk factor for Type 2 Diabetes, and adipocyte function abnormalities due to adipose hypertrophy and hyperplasia, have been linked to obesity. Numerous reports suggest that the intracellular and systemic consequences of adipocyte function abnormalities include adipocyte insulin resistance, enhanced production of free fatty acids, and production of inflammatory mediators. A hallmark of adipocyte insulin sensitivity is the stimulation of glucose transporter isoform 4 (GLUT4) trafficking events to promote glucose uptake. In the Type 2 diabetic and insulin resistant states the mechanism behind insulin-stimulated GLUT4 trafficking is compromised. Therefore, understanding the role of factors involved in glucose-uptake in adipose tissue is of great importance. Studies from our laboratory suggest an important role for the unconventional myosin, Myo1c, in promoting insulin-mediated glucose uptake in cultured adipocytes. Our observations suggest that depletion of Myo1c in cultured adipocytes results in a significant reduction in the ability of adipocytes to take up glucose following insulin treatment, suggesting Myo1c is required for insulin-mediated glucose uptake. A plausible mechanism by which Myo1c promotes glucose uptake in adipocytes has been suggested by further work from our laboratory in which expression of fluorescently-tagged Myo1c in cultured adipocytes induces significant membrane ruffling at the cell periphery, insulin-independent GLUT4 translocation to the cell periphery, and accumulation of GLUT4 in membrane ruffling regions. Taken together Myo1c seems to facilitate glucose uptake through remodeling of cortical actin. In the first part of this thesis I, in collaboration with others, uncovered a possible mechanism through which Myo1c regulates adipocyte membrane ruffling. Here we identified a novel protein complex in cultured adipocytes, comprising Myo1c and the mTOR binding partner, Rictor. Interestingly our studies in cultured adipocytes suggest that the Rictor-Myo1c complex is biochemically distinct from the Rictor-mTOR complex of mTORC2. Functionally, only depletion of Rictor but not Myo1c results in decreased Akt phosphorylation at serine 473, but depletion of either Rictor or Myo1c results in compromised cortical actin dynamic events. Furthermore we observed that whereas the overexpression of Myo1c in cultured adipocytes causes remarkable membrane ruffling, Rictor depletion in cells overexpressing Myo1c significantly reduces these ruffling events. Taken together our findings suggest that Myo1c, in conjunction with Rictor, modulates cortical actin remodeling events in cultured adipocytes. These findings have implications for GLUT4 trafficking as GLUT4 has been previously observed to accumulate in Myo1c-induced membrane ruffles prior to fusion with the plasma membrane. During our studies of adipocyte function we noticed that current siRNA electroporation methods present numerous limitations. To silence genes more effectively we employed a lentivirus-mediated shRNA delivery system, and to standardize this technology in cultured adipocytes we targeted Myo1c and MAP4K4. Using this technology we were able to achieve clear advantages over siRNA oligonucleotide electroporation techniques in stability and permanence of gene silencing. Furthermore we showed that the use of lentiviral vectors in cultured adipocytes did not affect insulin signaling or insulin-mediated glucose uptake events. Despite our inability to use lentiviral vectors to achieve gene silencing in mice we were able to achieve adipose tissue-specific gene silencing effects in mice following manipulation of the lentiviral conditional silencing vector, and then crossing resulting founders with aP2-Cre mice. Interestingly however, only founders from the MAP4K4 conditional shRNA vector, but not founders from the Myo1c conditional shRNA vector, showed gene knockdown, possibly due to position-effect variegation. Taken together, findings from these studies are important because they present an alternative means of achieving gene silencing in cultured adipocytes, with numerous advantages not offered by siRNA oligonucleotide electroporation methods. Furthermore, the in vivo, adipose tissue-specific RNAi studies offer a quick, inexpensive, and less technically challenging means of achieving adipose tissue-specific gene ablations relative to traditional gene knockout approaches.

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7

Kwok, Connie Sau-Kuen. "Development of self-assembled molecular structures on polymeric surfaces and their applications as ultrasonically responsive barrier coatings for on-demand, pulsatile drug delivery /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7999.

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8

Oslowski, Christine M. "TXNIP is a Mediator of ER Stress-Induced β-Cell Inflammation and Apoptosis: A Dissertation". eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/611.

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Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. The pathogenesis of these diseases involves β-cell dysfunction and death. The primary function of β-cells is to tightly regulate the secretion, production, and storage of insulin in response to blood glucose levels. In order to manage insulin biosynthesis, β-cells have an elaborate endoplasmic reticulum (ER). The ER is an essential organelle for the proper processing and folding of proteins such as proinsulin. Proteins fold properly when the ER protein load balances with the ER folding capacity that handles this load. Disruption of this ER homeostasis by genetic and environmental stimuli leads to an accumulation of misfolded and unfolded proteins, a condition known as ER stress. Upon ER stress, the unfolded protein response (UPR) is activated. The UPR is a signaling network that aims to alleviate ER stress and restore ER homeostasis promoting cell survival. Hence, the UPR allows β-cells to handle the physiological fluctuations of insulin demand. However upon severe unresolvable ER stress conditions such as during diabetes progression, the UPR switches to pathological outputs leading to β-cell dysfunction and apoptosis. Severe ER stress may also trigger inflammation and accumulating evidence suggests that inflammation also contributes to β-cell failure, but the mechanisms remain elusive. In this dissertation, we demonstrate that thioredoxin interacting protein (TXNIP) mediates ER stress induced β-cell inflammation and apoptosis. During a DNA microarray analysis to identify novel survival and death components of the UPR, we identified TXNIP as an interesting proapoptotic candidate as it has been linked to glucotoxicity in β-cells. During our detailed investigation, we discovered that TXNIP is selectively expressed in β-cells of the pancreas and is strongly induced by ER stress through the IRE1α and PERK-eIF2α arms of the UPR and specifically its transcription is regulated by activating transcription factor 5 (ATF5) and carbohydrate response element binding protein (ChREBP) transcription factors. As TXNIP has been shown to activate the Nod-like receptor protein 3 (NLRP3) inflammasome leading to the production of the inflammatory cytokine interleukin-1β (IL- 1β), we hypothesized that perhaps TXNIP has a role in IL-1β production under ER stress. We show that ER stress can induce IL-1β production and that IL-1β is capable of binding to IL-1 type 1 receptor (IL-1R1) on the surface of β-cells stimulating its own expression. More importantly, we demonstrate that TXNIP does indeed play a role in ER stress mediated IL-1β production through the NLRP3 inflammasome. Furthermore, we also confirmed that TXNIP is a mediator of β-cell apoptosis under ER stress partially through IL-1β signaling. Collectively, we provide significant novel findings that TXNIP is a component of the UPR, mediates IL-1β production and autostimulation, and induces cell death under ER stress in β-cells. It is becoming clear that TXNIP has a role in the pathogenesis of diabetes and is a link between ER stress, oxidative stress and inflammation. Understanding the molecular mechanisms involved in TXNIP expression, activity, and function as we do here will shed light on potential therapeutic strategies to tackle diabetes.

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9

Thomas, Amandine. "Hypoxie intermittente et homéostasie glucidique : étude des mécanismes d'action cellulaire A hybrid model to study pathological mutations of the human ADP/ATP carriers Visceral white fat remodeling contributes to intermittent hypoxia-induced atherogenesis The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system The Impact of Sleep Disorders on Glucose Metabolism: Endocrine and Molecular Mechanisms Endoplasmic reticulum stress as a novel inducer of hypoxia inducible factor-1 activity: its role in the susceptibility to myocardial ischemia-reperfusion induced by chronic intermittent hypoxia Chronic intermittent hypoxia improves whole-body glucose tolerance by activating skeletal muscle AMP-activated protein kinase in mice Prolyl-4-hydroxylase 1 (PHD1) deficiency impairs whole-body glucose tolerance and insulin sensitivity in mice but does not worsen high-fat diet-induced metabolic dysfunctions Specific transcriptomic signature in response to intermittent hypoxia exposure in liver and fat tissue." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV044.

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L'hypoxie intermittente (HI), induite par les apnées du sommeil, conduit à des altérations de la sensibilité à l'insuline et de l'homéostasie glucidique mais les mécanismes impliqués restent mal connus. L'objectif de ce travail était d'étudier les effets et les mécanismes sous jacents d'une exposition chronique à l'HI sur l'homéostasie glucidique. L'HI induit une résistance à l'insuline à la fois systémique et tissulaire, ainsi qu'une amélioration de la tolérance au glucose associée à une activation de l'AMPK musculaire. L'HI cause également des altérations du foie et du tissu adipeux associées à un changement du pattern d'expression des gènes dans ces tissus et à un risque accru de développement de pathologies vasculaires comme l'athérosclérose. Enfin, la délétion de PHD1, une des protéines régulatrices de HIF-1, entraîne une résistance à l'insuline associée une stéatose hépatique, faisant de HIF-1 une cible potentielle impliquée dans les altérations metaboliques induites par l'HI
Intermittent hypoxia (IH), induced by sleep apnea, leads to alterations in insulin sensitivity and glucose homeostasis but the mechanisms involved remains poorly understood. The objective of this work was to study the effects and the underlying mechanisms of chronic exposure to IH on glucose homeostasis. IH induces both systemic and tissue-specific insulin resistance , as well as improved glucose tolerance associated with an activation of muscle AMPK. IH also causes a change in the pattern of gene expression in liver and adipose tissue and an increased risk of vascular pathologies such as atherosclerosis development. Finally, the deletion of PHD1, a regulatory protein of HIF-1, leads to insulin resistance associated with hepatic steatosis, making HIF-1 a possible target involved in the metabolic changes induced by IH

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10

LIN, Cheng-wei, and 林政衛. "Preparation of N,O-carboxymethyl Chitosan Nanoparticle as an Insulin Carrier." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/67647655940267538496.

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碩士
國立雲林科技大學
化學工程與材料工程研究所
95
The aim of this research is to Preparation N,O-carboxymethyl chitosan (NOCC)which is derivative of chitosan. Insulin- N,O-carboxymethyl chitosan nanoparticle were prepared by ionic gelation of N,O- carboxymethyl chitosan and tripolyphosphate pentasodium(TPP). The NOCC/TPP mass ratio and insulin initial concentration were studied and how influence insulin release phenomena. The physicochemical properties of nanoparticles were determined by particle size, zeta potential analysis, transmission electron microscope, FTIR, SS-NMR and XRD. Release study was conducted by in vitro investigation to simulate intestinal fluid and gastric fluid at 37℃. Insulin release were analysed by RP-HPLC. The result shows particles size increased with increasing NOCC/TPP mass ratio. All nanoparticles prepared by ionic gelation which zeta potential was positive. Release rate were decreased with decreasing NOCC/TPP mass ratio and increased with decreasing insulin initial concentration. The release profiles were fitted very well by the Higuchi release model.

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Книги з теми "Insulin carrier"

1

C, Baxter R., Gluckman Peter D, and Rosenfeld Ron G, eds. The insulin-like growth factors and their regulatory proteins: Proceedings of the Third International Symposium on Insulin-Like Growth Factors, Sydney, 6-10 February 1994. Amsterdam: Excerpta Medica, 1994.

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2

Baxter, R. C., and Peter D. Gluckman. The Insulin-Like Growth Factors and Their Regulatory Proteins: Proceedings of the Third International Symposium on Insulin-Like Growth Factors, Sydn (International Congress Series). Elsevier Science Pub Co, 1994.

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3

Dreval, Alexander. Professional and flash on the monitoring of blood glucose levels of insulin pump therapy and without it. Aegitas publishing house, 2021. http://dx.doi.org/10.47359/978-0-369-40455-8.

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A new method of self-control of diabetes based on the results of continuous monitoring of glycemia (HMG) is especially relevant in patients who are on pump insulin therapy, especially since the start of pump insulin therapy is carried out with the mandatory installation of the HMG system [1,3]. Due to the novelty of these two methods (treatment of diabetes and control of glycemia) for a wide clinical practice, there is an urgent need to publish concise practical guides on this topic for doctors, both for self-study of these methods, and for advanced training courses. Based on the above and our experience of teaching at the Department of Endocrinology of the Federal Medical University of MONICA, this guide has been prepared, which will be useful, first of all, for endocrinologists, therapists working with patients with diabetes, as well as for senior students of medical institutes who are interested in new directions in practical medicine.

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4

Williamson, Arthur. David Hume, Richard Verstegan, and the Battle for Britain. Edited by Malcolm Smuts. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199660841.013.19.

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This chapter considers the debate about Anglo-Scottish union that accompanied James VI’s accession to the southern Crown. Through an analysis of David Hume of Godscroft’sDe Unione insulae Britannicaeand Richard Verstegan’sA Restitution of decayed intelligence, both published on 1605, it argues that the prospective union was far more politically fraught and intellectually significant than commonly recognized. Unionists like Hume urged ethnic erasure through the forging of a common British identity within an integrated British state. Brito-Sceptics like Verstegan stressed ethnic difference to the point of adopting Tacitean racial vocabularies. Precocious historical linguistics underlay each side. Each carried at its center a competing religious agenda. These matrices provide a frame for understanding the contemporary writings of such figures as Richard Hooker, William Camden, and William Shakespeare.

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Частини книг з теми "Insulin carrier"

1

Wong, Tin Wui, Uttamkumar Mandal, and Li-Jiuan Shen. "Chitosan and Alginate Nanoparticles as Oral Insulin Carrier." In Patenting Nanomedicines, 345–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-29265-1_11.

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2

Zapf, J., E. Schoenle, and E. R. Froesch. "In vivoEffects of the Insulin-Like Growth Factors (IGFs) in the Hypophysectomized Rat: Comparison with Human Growth Hormone and the Possible Role of the Specific IGF Carrier Proteins." In Novartis Foundation Symposia, 169–87. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720974.ch11.

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Nicolau, C., A. Legrand, and E. Grosse. "Liposomes as Carriers for in Vivo Transfer and Expression of the Insulin Gene." In Modern Trends of Colloid Science in Chemistry and Biology, 240–60. Basel: Birkhäuser Basel, 1985. http://dx.doi.org/10.1007/978-3-0348-6513-5_12.

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4

Guillén-Martín, Cayetano, and Carmen Romero. "Volcanic Geomorphology in El Hierro Global Geopark." In Geoheritage, Geoparks and Geotourism, 33–42. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-07289-5_3.

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AbstractFew oceanic islands express their geomorphological history in such a marked way as the island of El Hierro. Indeed, on El Hierro, its geomorphology goes hand in hand with the evolution of its insular geology. In fact, seventy percent of places of geological interest in El Hierro’s Geopark have geomorphological features as their main or secondary interest, which is indicative of the importance of geomorphology in the configuration of the island’s relief. However, there are few studies that have addressed the processes or features of the island’s geomorphology. In this study, the first geomorphological characterization is carried out in which the island is considered as a whole unit.

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5

M., Amani. "Oral Delivery of Insulin: Novel Approaches." In Recent Advances in Novel Drug Carrier Systems. InTech, 2012. http://dx.doi.org/10.5772/52265.

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6

Sonia, Thundiparambil Azeez, and Chandra P. Sharma. "Experimental techniques involved in the development of oral insulin carriers." In Oral Delivery of Insulin, 169–217. Elsevier, 2014. http://dx.doi.org/10.1533/9781908818683.169.

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7

Patil, Nilam H., and Padma V. Devarajan. "Colloidal carriers for noninvasive delivery of insulin." In Colloid and Interface Science in Pharmaceutical Research and Development, 411–42. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-444-62614-1.00020-x.

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8

Chlup, Rudolf, Ondřej Krystyník, Petr Mlčák, Jana Zapletalová, and Josef Bartek. "Intensive Management of Type 1 Diabetes in Adults: One Centre Experience 1970–2022." In Type 1 Diabetes Mellitus [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108032.

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This chapter deals with clinical trials and routine management of persons with type 1 diabetes (PWD1) carried out at the Teaching Hospital and Palacký University Olomouc since 1970 in cooperation with experts from other centres. The following outcomes are presented: (1) physical training resulted in (a) enhancement of physical working capacity; (b) increased insulin effectiveness (c) increased S-HDL cholesterol; (d) improvement of neuropathy, memory, attention and general condition of PWD1. (2) Intensive basal and prandial insulin substitution with only short-acting insulin given seven times a day and night appeared to be the most effective approach to the conventional insulin substitution; group education and pens motivated to the intensification of insulin therapy. (3) Continuous subcutaneous insulin infusion, conventional self-monitoring, continuous/flush glucose monitoring and prolongation of time in range opened new horizons. Intensive education, early application of hybrid insulin pumps and specialised prevention of late diabetes complications are deemed to improve the life expectancy and quality. Cooperation with insurance companies should be acknowledged.

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9

Hall, Kersten T. "The Prophet in the Labyrinth." In Insulin - The Crooked Timber, 219–51. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780192855381.003.0011.

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Sanger’s application of partition chromatography to the analysis of insulin was crucial in showing that different proteins have a defined sequence of amino acids arranged in a specific order. But thanks to its application by Erwin Chargaff, Martin’s and Synge’s method was also central in explaining how DNA carried genetic information. Using partition chromatography, Chargaff found striking differences in the relative amounts of nucleotide bases from nucleic acids in different species. This offered the first hint that genetic information might reside at the level of the sequence of bases. Chargaff’s analysis also played a crucial role in Watson’s and Crick’s double-helical model of DNA, first published in 1953, after which a number of scientists (George Gamow, Francois Jacob, Jacques Monod, Marshall Nirenberg) showed how the sequence of nucleotide bases in DNA determined the precise order of amino acids in a protein.

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Hall, Kersten T. "Be Careful What You Wish For." In Insulin - The Crooked Timber, 124–36. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780192855381.003.0007.

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Charles Best’s efforts to establish himself as the key figure in the story of insulin were largely successful. But towards the end of his life, his account faced a new challenge. This was due to the discovery of the work of Nicolai Paulescu, a Romanian physiologist who had carried out very similar experiments at around the same time as Banting and Best. Professor Ion Pavel’s long-fought campaign to have Paulescu recognized was eventually successful, but a ceremony planned by the International Diabetes Federation to honour Paulescu in 2003 was cancelled by the sudden and shocking revelation that he had been a vocal and active anti-Semite whose extremist political writings had played a role in instigating the Romanian Holocaust. Paulescu, finally achieved the recognition that he craved throughout his life, but it was certainly not for the discovery of insulin.

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Тези доповідей конференцій з теми "Insulin carrier"

1

Mukerjee, A., V. Pruthi, and V. R. Sinha. "Preparation and Characterization of Poly-ε-caprolactone Carrier Particles for Controlled Insulin Delivery." In International Conference on Biomedical and Pharmaceutical Engineering 2006. ICBPE 2006. IEEE, 2006. http://dx.doi.org/10.1109/icbpe.2006.348599.

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Yang, Y., MA Becker, and D. Yee. "P2-03-03: An Insulin-Like Growth Factor I (IGF-I)-Induced Gene, Solute Carrier Family 7 Member 11 (SLC7A11)/xCT, Mediates IGF-I-Induced Biological Behaviors in Breast Cancer Cells." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p2-03-03.

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3

Nogueira, Fábio Dias, Ana Klara Rodrigues Alves, Barbara Beatriz Lira da Silva, Ana Kamila Rodrigues Alves, Marlilia Moura Coelho Sousa, Ana Karla Rodrigues Alves, Wanderson da Silva Nery, Breno Carvalho de Almeida, Flávia Dias Nogueira, and Leiz Maria Costa Véras. "The relationship of diabetes mellitus with Alzheimer’s disease: a literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.280.

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Introduction: Alzheimer’s disease (AD) is closely related to diabetes mellitus (DM), and AD is also considered to be type 3 diabetes (T3D). Glycogen synthase kinase-3β (GSK-3β) may be the potential link between DM and AD. GSK-3β is one of the main factors that lead to insulin deficiency and insulin resistance, and insulin resistance is a characteristic of the development of DM. In AD, GSK-3β plays an important role in hyperphosphorylation of the tau protein (tau) associated with microtubules, which is one of the pathological features in AD. Objective: To analyze DM as a factor for the development of AD. METHODOLOGY: This is an integrative review of the literature, which is a construction of a comprehensive analysis of the literature with pre-defined steps, carried out through PubMed, 1.501 articles were found, of which 10 were selected, through the simultaneous crossing between the descriptors “Diabetes mellitus”, “Alzheimer “. Articles written in Portuguese and English published between 2016 and 2021 were inserted. Results: DM associated with insulin resistance affects psychomotor efficiency, attention, learning memory, mental flexibility, speed and executive function of the brain, thus being an independent risk factor for cognitive impairment and damage to the central nervous system, hyperglycemia, which can cause increased oxidative stress leading to progressive functional and structural abnormalities in the brain. Conclusion:The risk of dementia in patients with DM is higher than in nondiabetic patients and it is also well known that DM2 / insulin resistance is involved in AD.

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Akel, Hussein, Gábor Katona, and Ildikó Csóka. "In vitro quantitative comparison study of insulin SLNs and PLGA NPs as potential carriers for the brain delivery of intranasal insulin." In IV. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2022. http://dx.doi.org/10.14232/syrptbrs.2022.24.

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Samama, M., and C. E. Baudoin. "EFFECT OF ASPIRIN AND ASPIRIN COMBINED WITH DIPYRIDAMOLE IN EARLY DIABETIC RETINOPATHY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643855.

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In a double blind randomised controlled clinical trial the effect of antiplatelet agents (aspirin 330 mg × 3 × day) or in combination with dipyridamole (75 mg 3 × day) versus placebo, was tested in 475 patients with early diabetic retinopathy. Patients were follewed fourmonthly for 3 years. Ophtalmological examinations were carried out initially and at yearly intervals. The assessment of retinopathy was based on changes in the number of microaneurysms (MA) present in the macular field as seen on fluorescein angiograms over a period of three years. Forty one patients did not complete the study. Among the others at least three readable initial and yearly angiograms were available on 420 patients who had a 3 year follow up (266 insulin treated and 154 non insulin treated). The results are based on these patients.It is concluded that either Aspirin alone or in conjunction with dipyridamole significantly slows down the progression of MA evolution in early diabetic retinopathy. Because of the very small, although significant changes, the clinical relevance of these drugs has not been established.

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Lammert, J., S. Grill, M. Yahiaoui-Doktor, M. Basrai, J. Struck, O. Hartmann, SC Bischoff, M. Halle, and M. Kiechle. "High circulating levels of adrenomedullin are associated with metabolic syndrome, insulin resistance and low cardiorespiratory fitness in BRCA1 and BRCA2 mutation carriers." In Kongress Ernährung 2020 – Medizin fürs Leben. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1710236.

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7

Bannikova, S. A. "ФАКТОРЫ, ВЛИЯЮЩИЕ НА ТИП ПСИХОЛОГИЧЕСКОГО КОМПОНЕНТА ГЕСТАЦИОННОЙ ДОМИНАНТЫ". У ПЕРВЫЙ МЕЖКОНТИНЕНТАЛЬНЫЙ ЭКСТЕРРИТОРИАЛЬНЫЙ КОНГРЕСС «ПЛАНЕТА ПСИХОТЕРАПИИ 2022: ДЕТИ. СЕМЬЯ. ОБЩЕСТВО. БУДУЩЕЕ». Crossref, 2022. http://dx.doi.org/10.54775/ppl.2022.44.52.001.

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Purpose: for implementation of comprehensive assistance to pregnant women diagnosed with systolic pressure gradient, the study of a type of the psychological component of the gestational dominance was conducted in Maternity Hospital, City Clinical Hospital Nº 29 in Moscow (hereinafter referred to as PCGD). Materials and methods: The study compared PCGD of women with systolic pressure gradient and PCGD of women with other diagnoses, who received inpatient care in the pregnancy pathology department in Maternity Hospital, City Clinical Hospital Nº 29 in 2022. 680 pregnant women with a pregnancy term from 25 till 41 weeks participated in the study. There were 161 women diagnosed with systolic pressure gradient, 101 having diet therapy, and 60 having insulin therapy. The study was carried out with the help of a questionnaire by Dobryakov I.V. «Clinical and psychological definition of a type of the psychological component of the gestational dominance». 161 The analysis revealed that social factors and diagnose do not influence a type of PCGD. About 23% of women with different dianoses have the optimal type of PCGD. Twenty-two percent of women diagnosed with systolic pressure gradient having diet therapy and twenty-four percent of women diagnosed with systolic pressure gradient having insulin therapy have the optimal type of PCGD. The results of the study revealed that PCGD depends on a woman’s weight. The women having a normal body mass index choose the statements of the optimal type of PCGD more often (28,9%), it is more than the average sample. As weight increases, the number of optimal choices decreases. In the case of obesity of the 2nd degree, the optimal type of PCGD is found in 16.7% of the surveyed pregnant women, in the case of obesity of the 3rd degree in 8.7%. The number of euphoric choices increases with the decline of optimal choices: from 24% at normal weight to 29% at obesity of the 2 and 3 degrees. The level of significance of this result is more than 95%. Conclusions: The study's finding is that the type of PCGD does not depend on social factors, and diagnosis of systolic pressure gradient of the women having diet therapy or insulin therapy. PCGD is dependent on the weight of a woman. Women with normal weight have the optimal type of PCGD more than twice as often. Obese women more often choose statements of euphoric PCGD. Цель: для реализации комплексной помощи беременным женщинам с диагнозом ГСД, в роддоме ГКБ№ 29 г. Москвы было проведено исследование типа психологического компонента гестационной доминанты (далее ПКГД). Материалы и методы: Проведено сравнение ПКГД женщин с ГСД и ПКГД женщин с другими диагнозами, которые находились на стационарном лечении в отделении патологии беременных роддома ГКБ№29 в 2022 году. В исследовании приняло участие 680 беременных женщин со сроками беременности от 25 до 41 недели. Из них н 161 женщина с диагнозом ГСД: 101 на диетотерапии и 60 на инсулинотерапии. Исследование проводилось при помощи опросника И.В.Добрякова «Клинико-психологическое определение типа психологического компонента гестационной доминанты». Анализ показал, что на тип ПКГД не влияют социальные факторы, диагноз, с которым женщина находится в стационаре. Примерно 23% женщин с разными диагнозами имеют оптимальный тип ПКГД. У женщин с диагнозом ГСД на диетотерапии 22,5% и ГСД на инсулинотерапии 24% ПКГД оптимального типа Результаты исследования показали, что ПКГД зависит от веса женщины. Женщины, имеющие нормальный индекс массы тела, чаще выбирают утверждения оптимального стиля ПКГД (28,9%), что больше чем в средней выборке. По мере увеличения веса тела, количество оптимальных выборов уменьшается. Так, при ожирении 2 степени оптимальный тип ПКГД встречается у 16,7% опрошенных беременных женщин, при ожирении 3 степени – у 8.7% . На фоне снижения оптимальных выборов растет количество эйфорических выборов: с 24% при нормальном весе до 29 процентов при ожирении 2, 3 степени. Уровень значимости данного результата более 95% Выводы: Из этого исследования можно сделать вывод, что тип ПКГД не зависит от социальных факторов, наличия у женщины диагноза ГСД на диетотерапии или инсулине. ПКГД имеет зависимость от веса женщины. Женщины с нормальным весом более чем в 2 раза чаще имеют оптимальный тип ПКГД. Женщины, страдающие ожирением, чаще выбирают утверждения эйфорического ПКГД.

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Tittmann, B. R., and C. Miyasaka. "Thermal and Acoustical Insult to Cells as Studied by In-Vivo Acoustic Microscopy." In ASME 2002 Pressure Vessels and Piping Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/pvp2002-1634.

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A plurality of articles discussing combined effects of acoustic high-pressure and heat caused by acoustic vibration on biological tissues and cells has been published. Herein, we contribute the article describing the behavior of living human skin cells when separately applying the pressure and the heat to them. First, for finding the heat effect, we located a container including living human skin cells and a culturing medium on the X-Y stage equipped with the heating plate with temperature controller of the Scanning Acoustic Microscope (SAM). Then, we gradually increased temperature of the culturing medium, and carried out in-situ observation. Second, for finding the acoustic high-power effect, we provided the pressure using high power ultrasonic pulses generated by a laser induced ultrasonic shock wave system to the cells, wherein the pressures caused by the pulses were measured by a hydrophone, and wherein temperature was monitored by thermocouples. The cells were observed with the SAM just after giving the impact. The difference between phenomena indicating cellular insult and injury (e.g., shrinkage or lift-off) were clearly visualized by the SAM with frequency at 1.0 GHz.

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9

Miladinović, Zoran. "OBAVEZNO OSIGURANjE PUTNIKA U JAVNOM PREVOZU OD POSLEDICA NESREĆNOG SLUČAJA." In XVIII Majsko savetovanje. University of Kragujevac, Faculty of Law, 2022. http://dx.doi.org/10.46793/xviiimajsko.269m.

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Transport of passengers in all branches of traffic by the nature of things and one type of dangerous activity. The possibility of an accident in public transport of passengers is a real fact, therefore special regulations regulate the obligations of the owners of transport to conclude a contract on insuring their liability for the consequences and damages that passengers and third parties suffer from their means, or from their activities, before putting them into traffic. It is a form of compulsory insurance against the consequences of an accident. That means that a passenger who is injured in a traffic accident in public transport is entitled to the sum insured on the basis of compulsory passenger insurance and compensation from carrier(there is possibility of accumulating compensation). The importance of this insurance is in the fact that passengers in public transport are covered by insurance under the law itself, which means that they are entited to compesationeven when the carrier has not concluded a passenger insurance contract or if the insurer with whom the insurance contract fell into bankruptcy. In the Republic of Serbia, this issue is well regulated by a separate Law on compulsory traffic insurance, whole provisions are mainly of imperative nature. It defines the persons who are obliged to obtain insurance policy for the transport of passengers, then identifies the persons who have passenger status, in terms of insurance policy, as well as prescribes the minimum amount of compensation that is covered by the insurance policy.

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10

Dintenfass, L. "AGGREGATES OF RED BLOOD CELLS, AND AGGREGATES OF PLATELETS UNDER ZERO GRAVITY: EXPERIMENT ON NASA SPACE SHUTTLE "DISCOVERY" STS 51-C, JANUARY l985." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644538.

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The aim of experiment "ARC" on the space shuttle "Discovery STS 51-C, was to define effect of zero gravity on kinetics and morphology of aggregation of red cells in blood obtained from patients suffering from ischaemic heart disease, colon cancer, insulin-dependent diabetes, hyperlipidaemia, IgG and IgM papa-proteins. Space-rated automated slit-capillary photo-viscometer contained a motorized infusion pump capable of handling eight different blood samples. Two cameras and a microscope allowed micro and macrophotography, and total of 500 photographs was obtained in space; and equivalent number on the ground, in the Kennedy Space Center, where a duplicate ground photo-viscometer was present. Identical blood samples have been used in the ground experiments. The slit had a gap of 12.5 microns (micrometers). Blood was anticoagulated with EDTA and adjusted to haematocrit of 0.30 using native plasma. Samples were kept at -5°C prior to the experiment, and at 25°C during experiment; duration of experiment was 91/2 hours. The same computer program was used in both instruments. Photography was carried out at set intervals up to six minutes from the moment of stasis. There was a drastic difference between aggregation on the ground and at zero gravity. Blood from patients was greatly sludged on the ground, but normal rouleaux were formed under zero gravity. Also, aggregates uikder zero g were much smaller. However, red cell shape was not changed. Blood samples from normal donors, which showed normal rouleaux on the ground, exhibited random swarm pattern under zero gravity. Platelets, which tended to aggregate on the ground, and tended to accummulate at the slit entrance, remained monodisperse under zero gravity and no pseudopodia have been noted; under zero g platelet moved through the slit. Subject to future confirmation, it is suggested that zero gravity affects cell-to-cell interaction, and probably causes a modification of the cell membrane. If this is true, a new vista opens in the studies of immunology and oncology under zero gravity.

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Звіти організацій з теми "Insulin carrier"

1

Hansen, Peter J., and Amir Arav. Embryo transfer as a tool for improving fertility of heat-stressed dairy cattle. United States Department of Agriculture, September 2007. http://dx.doi.org/10.32747/2007.7587730.bard.

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The overall objective of the current proposal is to develop procedures to improve the pregnancy rate achieved following transfer of fresh or cryopreserved embryos produced in the laboratory into heat-stress recipients. The overall hypothesis is that pregnancy rate in heat-stressed lactating cows can be improved by use of embryo transfer and that additional gains in pregnancy rate can be achieved through development of procedures to cryopreserve embryos, select embryos most likely to establish and maintain pregnancy after transfer, and to enhance embryo competence for post-transfer survival through manipulation of culture conditions. The original specific objectives were to 1) optimize procedures for cryopreservation (Israel/US), 2) develop procedures for identifying embryos with the greatest potential for development and survival using the remote monitoring system called EmbryoGuard (Israel), 3) perform field trials to test the efficacy of cryopreservation and the EmbryoGuard selection system for improving pregnancy rates in heat-stressed, lactating cows (US/Israel), 4) test whether selection of fresh or frozen-thawed blastocysts based on measurement of group II caspase activity is an effective means of increasing survival after cryopreservation and post-transfer pregnancy rate (US), and 5) identify genes in blastocysts induced by insulin-like growth factor-1 (IGF-1) (US). In addition to these objectives, additional work was carried out to determine additional cellular determinants of embryonic resistance to heat shock. There were several major achievements. Results of one experiment indicated that survival of embryos to freezing could be improved by treating embryos with cytochalasin B to disrupt the cytoskeleton. An additional improvement in the efficacy of embryo transfer for achieving pregnancy in heat-stressed cows follows from the finding that IGF-1 can improve post-transfer survival of in vitro produced embryos in the summer but not winter. Expression of several genes in the blastocyst was regulated by IGF-1 including IGF binding protein-3, desmocollin II, Na/K ATPase, Bax, heat shock protein 70 and IGF-1 receptor. These genes are likely candidates 1) for developing assays for selection of embryos for transfer and 2) as marker genes for improving culture conditions for embryo production. The fact that IGF-1 improved survival of embryos in heat-stressed recipients only is consistent with the hypothesis that IGF-1 confers cellular thermotolerance to bovine embryos. Other experiments confirmed this action of IGF-1. One action of IGF-1, the ability to block heat-shock induced apoptosis, was shown to be mediated through activation of the phosphatidylinositol 3-kinase pathway. Other cellular determinants of resistance of embryos to elevated temperature were identified including redox status of the embryo and the ceramide signaling pathway. Developmental changes in embryonic apoptosis responses in response to heat shock were described and found to include alterations in the capacity of the embryo to undergo caspase-9 and caspase-3 activation as well as events downstream from caspase-3 activation. With the exception of IGF-1, other possible treatments to improve pregnancy rate to embryo transfer were not effective including selection of embryos for caspase activity, treatment of recipients with GnRH.and bilateral transfer of twin embryos. In conclusion, accomplishments achieved during the grant period have resulted in methods for improving post-transfer survival of in vitro produced embryos transferred into heat-stressed cows and have lead to additional avenues for research to increase embryo resistance to elevated temperature and improve survival to cryopreservation. In addition, embryo transfer of vitrified IVF embryos increased significantly the pregnancy rate in repeated breeder cows.

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