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Добірка наукової літератури з теми "Insulin-like growth factor-binding proteins Molecular aspects"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 8 лютого 2022

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Статті в журналах з теми "Insulin-like growth factor-binding proteins Molecular aspects"

1

Wetterau, Lawrence A., Michael G. Moore, Kuk-Wah Lee, Melanie L. Shim, and Pinchas Cohen. "Novel Aspects of the Insulin-like Growth Factor Binding Proteins." Molecular Genetics and Metabolism 68, no. 2 (October 1999): 161–81. http://dx.doi.org/10.1006/mgme.1999.2920.

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2

Roberts, Charles T., and Derek Leroith. "11 Molecular aspects of insulin-like growth factors, their binding proteins and receptors." Baillière's Clinical Endocrinology and Metabolism 2, no. 4 (November 1988): 1069–85. http://dx.doi.org/10.1016/s0950-351x(88)80030-2.

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3

Wang, Peng-Fei, Xiaoyu Wang, Min Liu, Zheng Zeng, Caiji Lin, Wenwen Xu, Wenqing Ma, et al. "The Oncogenic Functions of Insulin-like Growth Factor 2 mRNA-Binding Protein 3 in Human Carcinomas." Current Pharmaceutical Design 26, no. 32 (September 24, 2020): 3939–54. http://dx.doi.org/10.2174/1381612826666200413080936.

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Анотація:
IGF2BP3 (also known as IMP3, KOC), a member of the insulin-like growth factor mRNA-binding protein family (IMPs), has been a research target in recent studies of promoting embryo development and exacerbating cancer. IGF2BP3 is ubiquitously expressed in early embryogenesis stages but limited in postembryonic stages, which is important in many physiological aspects such as stem cell renewal, morphological development and metabolism. A large number of studies show that IGF2BP3 interacts with many kinds of non-coding RNAs and proteins to promote cancer cell proliferation and metastasis and inhibit
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4

Ruan, Wenjing, Jing Deng, and Kejing Ying. "Novel Aspects of Insulin-like Growth Factor 1/insulin Network in Chronic Inflammatory Airway Disease." Current Medicinal Chemistry 27, no. 42 (December 16, 2020): 7256–63. http://dx.doi.org/10.2174/0929867326666191113140826.

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Анотація:
At least a proportion of patients suffering from chronic inflammatory airway diseases respond poorly to the bronchodilator and corticosteroid therapies. There is a need for the development of improved anti-inflammatory treatment. Insulin Growth Factor 1 (IGF1) and insulin participate in not only metabolism and glucose homeostasis, but also many other physiological and pathophysiological processes, including growth and inflammation. Recently, it was shown that not only the classical IGF1 and IGF1 Receptor (IGF1R), but also the other molecules in the IGF1/insulin network, including insulin, insu
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5

Pang, Ying, Xiaojun Zhang, Jianbo Yuan, Xiaoxi Zhang, Jianhai Xiang, and Fuhua Li. "Characterization and Expression Analysis of Insulin Growth Factor Binding Proteins (IGFBPs) in Pacific White Shrimp Litopenaeus vannamei." International Journal of Molecular Sciences 22, no. 3 (January 21, 2021): 1056. http://dx.doi.org/10.3390/ijms22031056.

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Анотація:
The insulin signaling (IIS) pathway plays an important role in the metabolism, growth, development, reproduction, and longevity of an organism. As a key member of the IIS pathway, insulin-like growth factor binding proteins (IGFBPs) are widely distributed a family in invertebrates and vertebrates that are critical in various aspects of physiology. As an important mariculture species, the growth of Pacific white shrimp, Litopenaeus vannamei, is one of the most concerning characteristics in this area of study. In this study, we identified three IGFBP genes in the genome of L. vannamei and analyz
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6

Ning, Yun, Alwin G. P. Schuller, Cheryl A. Conover, and John E. Pintar. "Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in Vivo." Molecular Endocrinology 22, no. 5 (May 1, 2008): 1213–25. http://dx.doi.org/10.1210/me.2007-0536.

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Abstract IGFs are required for normal prenatal and postnatal growth. Although actions of IGFs can be modulated by a family of IGF-binding proteins (IGFBPs) in vitro, these studies have identified a complicated pattern of stimulatory and inhibitory IGFBP effects, so that understanding relevant aspects of IGFBP action in vivo has been limited. Here we have produced a null mutation of one specific IGFBP, IGFBP-4, which is coexpressed with IGF-II early in development. Surprisingly, mutation of IGFBP-4, believed from in vitro studies to be exclusively inhibitory, leads to a prenatal growth deficit
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7

Dean, Richard A., Georgina S. Butler, Yamina Hamma-Kourbali, Jean Delbé, David R. Brigstock, José Courty, and Christopher M. Overall. "Identification of Candidate Angiogenic Inhibitors Processed by Matrix Metalloproteinase 2 (MMP-2) in Cell-Based Proteomic Screens: Disruption of Vascular Endothelial Growth Factor (VEGF)/Heparin Affin Regulatory Peptide (Pleiotrophin) and VEGF/Connective Tissue Growth Factor Angiogenic Inhibitory Complexes by MMP-2 Proteolysis." Molecular and Cellular Biology 27, no. 24 (October 1, 2007): 8454–65. http://dx.doi.org/10.1128/mcb.00821-07.

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ABSTRACT Matrix metalloproteinases (MMPs) exert both pro- and antiangiogenic functions by the release of cytokines or proteolytically generated angiogenic inhibitors from extracellular matrix and basement membrane remodeling. In the Mmp2 −/− mouse neovascularization is greatly reduced, but the mechanistic aspects of this remain unclear. Using isotope-coded affinity tag labeling of proteins analyzed by multidimensional liquid chromatography and tandem mass spectrometry we explored proteome differences between Mmp2 −/− cells and those rescued by MMP-2 transfection. Proteome signatures that are h
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8

Mancarella, Caterina, Andrea Morrione, and Katia Scotlandi. "Novel Regulators of the IGF System in Cancer." Biomolecules 11, no. 2 (February 12, 2021): 273. http://dx.doi.org/10.3390/biom11020273.

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Анотація:
The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF
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9

Jonas, Katharina, George A. Calin, and Martin Pichler. "RNA-Binding Proteins as Important Regulators of Long Non-Coding RNAs in Cancer." International Journal of Molecular Sciences 21, no. 8 (April 23, 2020): 2969. http://dx.doi.org/10.3390/ijms21082969.

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Анотація:
The majority of the genome is transcribed into pieces of non-(protein) coding RNA, among which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile molecules that govern basic cellular processes including transcription, splicing, RNA stability, and translation. The frequent deregulation of numerous lncRNAs in cancer is known to contribute to virtually all hallmarks of cancer. An important regulatory mechanism of lncRNAs is the post-transcriptional regulation mediated by RNA-binding proteins (RBPs). So far, however, only a small number of known cancer-associated lnc
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10

Huang, Xinqiang, Hong Cai, Ron Ammar, Yan Zhang, Yihe Wang, Kandasamy Ravi, John Thompson, and Gabor Jarai. "Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds." American Journal of Physiology-Gastrointestinal and Liver Physiology 316, no. 1 (January 1, 2019): G15—G24. http://dx.doi.org/10.1152/ajpgi.00281.2018.

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Precision-cut liver tissue slice (PCLS) contains all major cell types of the liver parenchyma and preserves the original cell-cell and cell-matrix contacts. It represents a promising ex vivo model to study liver fibrosis and test the antifibrotic effect of experimental compounds in a physiological environment. In this study using RNA sequencing, we demonstrated that various pathways functionally related to fibrotic mechanisms were dysregulated in PCLSs derived from rats subjected to bile duct ligation. The activin receptor-like kinase-5 (Alk5) inhibitor SB525334, nintedanib, and sorafenib each
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Більше джерел

Дисертації з теми "Insulin-like growth factor-binding proteins Molecular aspects"

1

Lucic, Melinda Robin. "Characterisation of the molecular interactions between insulin-like growth factors and their binding proteins." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phl9375.pdf.

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Анотація:
Addenda inserted in back. Includes bibliographical references (leaves 139-160) Assesses the importance of amino acids 221 to 236 of bIGFBP-2 for IGF binding activity, by creating amino acid substitutions.
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2

Gebski, Bijanka L. "Investigating TNF inhibition of IGF-1 signalling via JNK in cell culture models of skeletal muscle atrophy." University of Western Australia. School of Anatomy and Human Biology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0097.

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[Truncated abstract] The pro-inflammatory cytokine tumour necrosis factor (TNF) has a critical role in skeletal muscle atrophy. The catabolic effect of TNF is partially due to abrogation of the anabolic insulin-like growth factor 1 (IGF-1) signalling pathway. However, the precise signalling events that lead to the loss of myofibrillar protein following activation of TNF receptor are unknown. The over arching aim of the study is to determine the mechanisms of by which TNF induces atrophy in differentiated muscles cells. To achieve this aim a series of experiments were performed to: 1) investiga
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3

Mireuta, Matei. "Aspects of insulin-like growth factor binding proteins in cancer." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114128.

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Анотація:
The insulin-like growth factor (IGF) system is composed of two ligands (IGF-1 and IGF-2), two receptors (IGF-1R and IGF-2R) and six binding proteins (IGFBP-1 to -6). IGFs act as endocrine, paracrine and autocrine growth factors and stimulate cell growth, proliferation and metabolism. There is extensive evidence, both from in vitro and in vivo models as well as population studies, that IGF physiology is relevant to neoplasia. IGF-1R is the physiologic receptor for both ligands and its activation elicits a plethora of changes at the cellular level, such as activation of PI3K/AKT/mTOR and Ras/Raf
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4

Nickerson, Tara. "A role for insulin-like growth factor binding proteins in apoptosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0022/NQ50229.pdf.

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5

Ye, Siying. "Molecular characterization of insulin-regulated aminopeptidase (IRAP) /." Connect to thesis, 2006. http://eprints.unimelb.edu.au/archive/00001651.

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6

Bischler, Troy K., and University of Lethbridge Faculty of Arts and Science. "The utility of resting levels of IGF-I and IGFBP-3 as markers of training status in elite athletes." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, c2007, 2007. http://hdl.handle.net/10133/651.

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Анотація:
Insulin-like growth factor-I (IGF-I) and its principle binding protein (IGFBP-3) are believed to play a role in mediating the anabolic effects of exercise. The purpose of this study was to assess the effect of 4 months of training on IGF-I and IGFBP-3, and to determine if changes in IGF-I or IGFBP-3 were related to changes in training status. Twelve varsity swimmers (5 males, 7 females) were tested pre-season, and again after 8 and 16 weeks of training. Measures included: VO2 max, nutritional status, athletic performance, subjective symptoms of overtraining, and serum levels of IGF-I and IGFBP
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7

Higdon, Jane V. "Effects of acute heavy resistance exercise on serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in older men and women." Thesis, 1996. http://hdl.handle.net/1957/33977.

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8

Leibowitz, Brian J. "Molecular regulation of insulin-like growth factor binding protein-3 and its role in ribotoxic stress-induced apoptosis." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17343.

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9

Brandimarto, Jeffrey Alan. "Molecular regulation of insulin-like growth factor binding protein-5 by signaling molecules downstream of the IGF-I receptor in mammary epithelial cells." 2009. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000050495.

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10

Shilpa, S. Patil. "Mechanistic Insights into the Role of IGFBP-2 in Glioblastoma." Thesis, 2015. http://etd.iisc.ernet.in/2005/3952.

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Insulin like Growth Factor Binding Proteins (IGFBPs) 1 to 6 have important physiological functions of regulating half life and bioavailability of Insulin like Growth Factors (IGFs). Consequently, these have been known to play important roles in embryonic development, postnatal growth and disease conditions like cancer. However, the physiological roles of IGFBPs are diverse and not restricted only to the IGF regulation. These molecules are found to be tumor suppressors or promoters depending on the physiological contexts. IGFBP-2 has been established as a tumor promoter and found to be unregula
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Книги з теми "Insulin-like growth factor-binding proteins Molecular aspects"

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service), SpringerLink (Online, ed. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics. Boston, MA: Springer Science+Business Media, LLC, 2012.

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2

Cellular receptors for human growth hormone: Quantitative aspects and clinical applications. Leuven: Leuven University Press, 1988.

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3

International Symposium on Molecular and Cellular Biology of Insulin and IGFs (3rd 1990 Gainesville, Fla.). Molecular biology and physiology of insulin and insulin-like growth factors. New York: Plenum Press, 1991.

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4

Kazue, Takano, Hizuka Naomi, and Takahashi Shinʼichirō 1959-, eds. Molecular mechanisms to regulate the activities of insulin-like growth factors: Proceedings of the 4th International Symposium on Insulin-like Growth Factors, at Tokyo International Forum, Tokyo, Japan, 21-24 October 1997. Amsterdam: Elsevier, 1998.

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5

1945-, LeRoith Derek, ed. Insulin-like growth factors: Molecular and cellular aspects. Boca Raton: CRC Press, 1991.

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6

(Editor), Derek LeRoith, Walter Zumkeller (Editor), and Robert C. Baxter (Editor), eds. Insulin-like Growth Factor Receptor Signalling (Molecular Biology Intelligence Unit). Springer, 2003.

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7

Jr, Roberts Charles T., and Rosenfeld Ron G, eds. The IGF system: Molecular biology, physiology, and clinical applications. Totowa, N.J: Humana Press, 1999.

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8

(Editor), Ron G. Rosenfeld, and Charles T. Roberts (Editor), eds. The Igf System: Molecular Biology, Physiology, and Clinical Applications (Contemporary Endocrinology). Humana Press, 1999.

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9

LeRoith, Derek. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics. Springer, 2011.

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10

Higdon, Jane V. Effects of acute heavy resistance exercise on serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in older men and women. 1996.

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Частини книг з теми "Insulin-like growth factor-binding proteins Molecular aspects"

1

Sandhu, Manjinder S. "Insulin-Like Growth Factor-I and Risk of Type 2 Diabetes and Coronary Heart Disease: Molecular Epidemiology." In IGF-I and IGF Binding Proteins, 44–54. Basel: KARGER, 2005. http://dx.doi.org/10.1159/000085755.

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2

Clemmons, David R. "The Role of Insulin-Like Growth Factor Binding Proteins in Controlling the Expression of IGF Actions." In Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors, 381–94. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5685-1_32.

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3

Baxter, Robert C. "Chapter 5 Molecular aspects of insulin-like growth factor binding proteins." In Advances in Molecular and Cellular Endocrinology, 123–59. Elsevier, 1997. http://dx.doi.org/10.1016/s1569-2566(97)80036-1.

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4

Pell, J. M., and J. Glassford. "Insulin-like growth factor-I and its binding proteins: role in post-natal growth." In Molecular Physiology of Growth, 13–34. Cambridge University Press, 1996. http://dx.doi.org/10.1017/cbo9780511629075.002.

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5

Georgievna Sokolova, Mariia, and Ekaterina Valentinovna Lopatina. "Role of Growth Factors and Apoptosis Proteins in Cognitive Disorder Development in Patients with Duchenne Muscular Dystrophy." In Muscular Dystrophy - Research Updates and Therapeutic Strategies. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.92543.

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Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease; it occurs due to a mutation in the dystrophin protein gene; as a result, the protein is not synthesized and muscle tissue dies. On the one hand, we can say that this disease has been sufficiently studied; however, it is still incurable, and there are a number of issues remaining unclear in terms of the development of progressive dementia as a symptom in 30% of patients with Duchenne muscular dystrophy. We conducted a study at the intersection of molecular genetic, neurological, and enzyme-linked immunosorbent patients’ blood tests and experiments in organotypic culture, which allowed us to determine important points in the development of cognitive disorders in patients with Duchenne muscular dystrophy and identify a significant effect of growth factor concentration in patients. The chapter will present data on neurotrophic regulation in patients with Duchenne muscular dystrophy (by the best-studied neurotrophins), demonstrate special aspects of neuron-myocyte interaction, and broaden the understanding of the role of apoptosis and synthase proteins in the development of this disease. We would like to highlight the importance of prognostic criteria for the development of cognitive impairment and possible therapeutic measures to prevent progressive dementia
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Deochand, Chetram, Ming Tong, Amit R. Agarwal, Enrique Cadenas, and Suzanne M. de la Monte. "Tobacco Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration." In Advances in Alzheimer’s Disease. IOS Press, 2021. http://dx.doi.org/10.3233/aiad210015.

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Background: Human studies suggest tobacco smoking is a risk factor for cognitive impairment and neurodegeneration, including Alzheimer’s disease (AD). However, experimental data linking tobacco smoke exposures to underlying mediators of neurodegeneration, including impairments in brain insulin and insulin-like growth factor (IGF) signaling in AD are lacking. Objective: This study tests the hypothesis that cigarette smoke (CS) exposures can impair brain insulin/IGF signaling and alter expression of AD-associated proteins. Methods: Adult male A/J mice were exposed to air for 8 weeks (A8), CS for 4 or 8 weeks (CS4, CS8), or CS8 followed by 2 weeks recovery (CS8+R). Gene expression was measured by qRT-PCR analysis and proteins were measured by multiplex bead-based or direct binding duplex ELISAs. Results: CS exposure effects on insulin/IGF and insulin receptor substrate (IRS) proteins and phosphorylated proteins were striking compared with the mRNA. The main consequences of CS4 or CS8 exposures were to significantly reduce insulin R, IGF-1R, IRS-1, and tyrosine phosphorylated insulin R and IGF-1R proteins. Paradoxically, these effects were even greater in the CS8+R group. In addition, relative levels of S312-IRS-1, which inhibits downstream signaling, were increased in the CS4, CS8, and CS8+R groups. Correspondingly, CS and CS8+R exposures inhibited expression of proteins and phosphoproteins required for signaling through Akt, PRAS40, and/or p70S6K, increased AβPP-Aβ, and reduced ASPH protein, which is a target of insulin/IGF-1 signaling. Conclusion: Secondhand CS exposures caused molecular and biochemical abnormalities in brain that overlap with the findings in AD, and many of these effects were sustained or worsened despite short-term CS withdrawal.
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