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Добірка наукової літератури з теми "IT-ret"

Автор: Grafiati

Опубліковано: 25 липня 2024

Оновлено: 31 липня 2025

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Статті в журналах з теми "IT-ret"

Drilon, Alexander E., Dayong Zhai, Evan Rogers, et al. "The next-generation RET inhibitor TPX-0046 is active in drug-resistant and naïve RET-driven cancer models." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3616. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3616.

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3616 Background: RET fusions/mutations drive oncogenesis in lung and thyroid cancers, and several other malignancies. Selective RET inhibitors (selpercatinib/pralsetinib) are active in patients with these cancers; unfortunately, resistance often occurs. On-target resistance includes the acquisition of solvent front mutations (SFMs i.e. RET G810 substitutions). TPX-0046 is a structurally differentiated RET inhibitor that is potent against a range of RET fusions and mutations including SFMs. Methods: The rationally-designed, compact, macrocyclic RET/SRC inhibitor TPX-0046 was characterized in RE

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Ammer, Stefanie, Christian Lambertz, and Matthias Gauly. "Comparison of different measuring methods for body temperature in lactating cows under different climatic conditions." Journal of Dairy Research 83, no. 2 (2016): 165–72. http://dx.doi.org/10.1017/s0022029916000182.

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The aim of the research described here was to compare different methods of body temperature (BT) measurements in dairy cows. It was hypothesised that reticular temperature (RET) values reflect the physiological status of the animals in an equivalent way to rectal (RT) and vaginal (VT) measurements. RT, VT and RET temperatures of twelve lactating Holstein–Friesian cows were measured over five consecutive days in June and October 2013. While RT and VT were manually measured three times a day, RET was automatically recorded at 10 min intervals using a bolus in the reticulum. For comparison with R

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Hennige, Anita M., Reiner Lammers, Wolfgang Höppner, et al. "Inhibition of Ret Oncogene Activity by the Protein Tyrosine Phosphatase SHP1." Endocrinology 142, no. 10 (2001): 4441–47. http://dx.doi.org/10.1210/endo.142.10.8453.

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Abstract Germline mutations in the Ret protooncogene give rise to the inherited endocrine cancer syndromes MEN types 2A and 2B and familiar medullary thyroid carcinoma. Although it is well accepted that the constitutive active tyrosine kinase of Ret oncogenes ultimately leads to malignant transformation, it is not clear whether a decrease in the autophosphorylation of oncogenic Ret forms can affect the mitogenic and transforming activities of Ret. Potential modulators of the tyrosine kinase activity of Ret could be tyrosine phosphatases that are expressed in human thyroid tissue. Therefore, we

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Durick, Kyle, Gordon N. Gill, and Susan S. Taylor. "Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2." Molecular and Cellular Biology 18, no. 4 (1998): 2298–308. http://dx.doi.org/10.1128/mcb.18.4.2298.

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ABSTRACT Ret/ptc2 is a constitutively active, oncogenic form of the c-Ret receptor tyrosine kinase. Like the other papillary thyroid carcinoma forms of Ret, Ret/ptc2 is activated through fusion of the Ret tyrosine kinase domain to the dimerization domain of another protein. Investigation of requirements for Ret/ptc2 mitogenic activity, using coexpression with dominant negative forms of Ras and Raf, indicated that these proteins are required for mitogenic signaling by Ret/ptc2. Because activation of Ras requires recruitment of Grb2 and SOS to the plasma membrane, the subcellular distribution of

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Carlomagno, Francesca, Teresa Guida, Suresh Anaganti, et al. "Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474." Endocrine-Related Cancer 16, no. 1 (2009): 233–41. http://dx.doi.org/10.1677/erc-08-0213.

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ZD6474 (vandetanib, Zactima, Astra Zeneca) is an anilinoquinazoline used to target the receptor tyrosine kinase RET in familial and sporadic thyroid carcinoma (IC50: 100 nM). The aim of this study was to identify molecular determinants of RET sensitivity to ZD6474. Here, we show that mutation of RET tyrosine 806 to cysteine (Y806C) induced RET kinase resistance to ZD6474 (IC50: 933 nM). Y806 maps close to the gate-keeper position at the RET kinase nucleotide-binding pocket. Although tyrosine 806 is a RET auto-phosphorylation site, its substitution to phenylalanine (Y806F) did not markedly affe

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Jones, Stanton L. "Rational-Emotive Therapy in Christian Perspective." Journal of Psychology and Theology 17, no. 2 (1989): 110–20. http://dx.doi.org/10.1177/009164718901700203.

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Rational-emotive therapy (RET), a common cognitive-behavioral approach to psychotherapy, is critiqued from a Christian perspective. Positively, RET is openly value-oriented, prizing of rationality, and balanced in its attempt to deal with the thoughts, behaviors, and feelings of the client from a rational perspective. Such an approach can be a helpful tool for the Christian therapist to use. Difficulties with RET thought from a Christian perspective include incompatibilities with values endorsed by RET, an overemphasis on rationality, problems with the understanding of rationality and emotion,

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Wang, Lei, Yu Zhang, Yu Gao, et al. "Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma." Disease Markers 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/6870470.

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Metastatic renal cell carcinoma (RCC) presents a poor prognosis and an unpredictable course. To date, no validated biomarkers can predict the outcome of RCC. Ongoing efforts are conducted to identify the molecular markers of RCC progression, as well as the targets for novel therapeutic approaches. RET is a tyrosine kinase receptor which has been investigated as a possible target in other cancers because it is involved in oncogenic activation. To evaluate the predictive and prognostic functions of RET in ccRCC, a tissue microarray study was conducted on 273 ccRCC patients. Results showed that b

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Dawasaz, A. A., Ibrahim Alshahrani, Syed M. Yassin, et al. "Detection of Dental Caries’ and Dermatoglyphics’ Association with Relative Enamel Thickness Using CBCT Images in Saudi Subpopulation: A Novel Approach." BioMed Research International 2021 (July 26, 2021): 1–7. http://dx.doi.org/10.1155/2021/5550916.

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Background. Dental caries is the localized destruction of dental hard tissues (enamel and dentine). Decayed, Missing, and Filled Teeth (DMFT) index is the most commonly used dental caries index. Thickness of the outermost part of the tooth called the enamel is determined by the rate of deposition of enamel proteins. Relative enamel thickness (RET) gives a measure of enamel thickness with respect to dentine. Dental caries is influenced by a genetically determined factor called dermatoglyphics (DG). As the genes responsible for RET and DG lie on the same chromosome and develop during the same ti

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Zhang, Kai, Huajun Chen, Ye Wang, et al. "Clinical Characteristics and Molecular Patterns of RET-Rearranged Lung Cancer in Chinese Patients." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27, no. 5 (2019): 575–82. http://dx.doi.org/10.3727/096504018x15344979253618.

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RET rearrangement has been proven as an oncogenic driver in patients with lung cancer. However, the prevalence, clinical characteristics, molecular features, and therapeutic options in RET-rearranged patients remain unclear, especially in Chinese lung cancer patients. We retrospectively collected 6,125 Chinese lung cancer patients who have been profiled using next-generation sequencing (NGS). The clinical demographics and molecular features of RET rearrangement-positive patients were analyzed. RET rearrangements were identified in 84 patients with a proportion of 1.4% in our cohort. The median

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Corsini, Raymond J. "Putting the “B” in ret: It had to be." Journal of Rational-Emotive and Cognitive-Behavior Therapy 13, no. 1 (1995): 5–7. http://dx.doi.org/10.1007/bf02354554.

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Дисертації з теми "IT-ret"

Esteves, Cristiane Linge Exposito. ""Influência da técnica de desobturação e do limite de obturação na extrusão apical"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/23/23135/tde-21012005-102925/.

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O controle da extrusão apical durante a reintervenção endodôntica é essencial para o sucesso do novo tratamento. Nesse contexto, o presente estudo teve como objetivo comparar a quantidade de material sólido extruído na desobturação de canais radiculares variando-se a técnica de esvaziamento e o limite de obturação. Foram utilizados 40 incisivos inferiores previamente tratados divididos em dois grupos de acordo com o limite de obturação estabelecido. Cada grupo foi subdividido em dois subgrupos levando-se em conta a técnica de desobturação empregada; manual (subgrupos A1 e B1) e mecânico-rotató

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Книги з теми "IT-ret"

Greenstein, Stanley. Internationalisation of law in the digital information society. Edited by Nordic Conference on Law and Information Technology. Ex Tuto Publishing, 2013.

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Hyysalo, Sampsa, and Jouni K. Juntunen. User Innovation and Peer Assistance in Small-Scale Renewable Energy Technologies. Edited by Debra J. Davidson and Matthias Gross. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190633851.013.22.

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There have been many attempts to include citizens as more active players in the proliferation of renewable energy technologies. However, the roles that citizen users play in renewables proliferation are not limited to adoption, but include technological domestication, innovation, and market creation. This chapter first reviews innovation by citizen users in the early phases of small-scale renewable energy technologies (S-RET) technology development in wind turbines, solar collectors, and low-energy housing. It then examines user innovation and peer assistance in the later phases of diffusion i

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Bruns, Sebastian, and Sarandis Papadopoulos, eds. Conceptualizing Maritime & Naval Strategy. Nomos Verlagsgesellschaft mbH & Co. KG, 2020. http://dx.doi.org/10.5771/9783845299150.

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The 21st century is witnessing renewed tension as conflicts between major powers, serious concerns about future security alliances and global, even generational, security policy challenges arise. In the light of this, naval forces and maritime security, and understanding their underlying strategic rationale, are gaining momentum and importance. What are the roles and missions of naval forces, and how have states and the institutions themselves sought to frame their goals and methods? This book brings together experts from the United States, Europe, and Asia to reflect on how maritime and naval

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Частини книг з теми "IT-ret"

Heydarzadeh, Shabnam, and Mehdi Hedayati. "RET Proto-Oncogene Mutations: Impact on Diagnosis, Treatment and Prognosis of MTC." In Thyroid Cancer - The Road From Genes to Successful Treatment [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.108941.

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Variants of MTC result from different mutations in exons of the RET gene. RET proto-oncogene is activated by a DNA rearrangement and it is one of the first tyrosine kinase receptor (RTK) proteins found to play a role in neoplasia. Early detection using genetic screening has become the gold standard of therapy, followed by prophylactic thyroidectomy. RET-kinase inhibitors have been developed recently for the treatment of MTC and are currently at various phases of pre- and clinical trials. Numerous autosomal dominantly inherited mutations have been demonstrated to activate RET constitutively. Th

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Palmini, André, and Eliseu Paglioli. "The Irritative Zone and Seizure Onset Zone in Acute ECOG: The Quest for Relevant Epileptogenic Tissue." In Invasive Studies of the Human Epileptic Brain, edited by Samden D. Lhatoo, Philippe Kahane, and Hans O. Lüders. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198714668.003.0010.

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Acute intraoperative electrocorticography (ECoG) is a time-honoured technique to identify the relevant epileptogenic tissue (RET) and hence guide cortical resection to control medically refractory seizures. ECoG identifies the RET through careful analysis of pattern, morphology, frequency, and localization of interictal spikes recorded directly from the exposed cortical surface. Because the development and dissemination of chronic intracranial EEG recording techniques has put emphasis on ictal recordings (thus defining an ictal onset zone), acute ECoG is often considered unnecessary in surgica

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Kebebew, Electron, Douglas Wiseman, and Mustapha El Lakis. "Multiple Endocrine Neoplasia Type 2a and 2b." In Oxford Textbook of Endocrinology and Diabetes 3e, edited by Prakash Manoharan. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198870197.003.0118.

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Multiple endocrine neoplasia (MEN) type 2a (also referred to as type 2) is an inherited cancer syndrome in which an individual has medullary thyroid carcinoma, primary hyperparathyroidism, and/or phaeochromocytoma occurring either synchronously or metachronously. MEN type 2b (also referred to as type 3) comprises early onset medullary thyroid carcinoma and phaeochromocytoma in addition to phenotypical features such as ophthalmologic abnormalities, skeletal malformations, and a generalized ganglioneuromatosis. MEN 2a and 2b (MEN 2 and 3) are caused by germline mutations in the RET proto-oncogen

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Raue, Friedhelm, and Karin Frank-Raue. "Medullary Thyroid Carcinoma." In Oxford Textbook of Endocrinology and Diabetes 3e, edited by John A. H. Wass, Wiebke Arlt, and Robert K. Semple. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198870197.003.0080.

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Medullary thyroid carcinoma (MTC) is a rare calcitonin (Ctn)-secreting tumour of the C cells of the thyroid. MTC often have the clinical and histological features of neuroendocrine tumours. They account for 3–5% of all thyroid carcinomas and occur in both sporadic (70%) and hereditary forms (30%). The familial variety of MTC is inherited as an autosomal dominant trait with a high degree of penetrance and is associated with multiple endocrine neoplasia type 2 syndrome. It is caused by germline-activating mutations of the RET proto-oncogene. Detection of MTC in patients has changed in recent yea

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Gatrell, V. A. C. "Hanging People." In The Hanging Tree. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198204138.003.0002.

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Abstract The Ways In Which People Were Killed On Public Scaf folds have always been shrouded in euphemism. Home secretaries would keep an emotional distance from their own orders as they pen cilled on the appeal dossiers of those they left to die a phrase sanitized by repetition: ‘The law to take its course.’ Newspapers likewise would tersely report that felons were ‘launched into eternity’. It was as if when justice was done, thought and feeling had to be muffled. We are still ret icent on the subject. Now that sexual taboos have fallen, what was and is entailed in death by execution may be o

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Boelaert, Kristien, and Anthony P. Weetman. "Thyroid cancer." In Oxford Textbook of Medicine, edited by Mark Gurnell. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0247.

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Thyroid cancers are the most common endocrine malignancies and their incidence is rising globally, largely due to significant increases in small, incidentally detected low-risk tumours. Follicular epithelial cell cancer is the commonest type; this usually presents with usually well differentiated tumours and has an excellent prognosis, but occasionally highly undifferentiated; it may be induced by exposure to ionizing radiation. Medullary thyroid carcinoma arises from parafollicular C cells; it comprises 3–5% of all thyroid cancers; usually hereditary autosomal dominant forms associated with g

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Woessner, J. Frederick, and Hideaki Nagase. "Introduction." In Matrix Metalloproteinases and TlMPs. Oxford University PressOxford, 2000. http://dx.doi.org/10.1093/oso/9780198502685.003.0001.

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Abstract It is a simple matter to trace the roots of this field. Although it had long been recognized that con nective tissue collagen was rapidly broken down in many physiological situations, such as bone remodelling, postpartum involution of the uterus and embrvogenesis, and in pathological process, such as decubitus ulcer, cancer and arthritis [1431, there was no evidence identifying the degradative factor(s) involved. Then in 1962, Gross and Lapiere [672] demonstrated that skin from the resorbing tail of the metamorphosing frog, when cultured on collagen gels, released an enzyme that could

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White, Peter B. "Militarized Ministries of Defense?" In Reconsidering American Civil-Military Relations. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780197535493.003.0007.

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General (Ret.) James Mattis’s tenure as secretary of defense represents a rarity in US history, in that at only one other time has the United States had a retired general in that post. This chapter places Mattis’s tenure in a comparative context. It leverages new data on comparative ministries of defense to examine patterns in the military background of ministers of defense (MoD) across a range of countries from 1964 to 2008. The analysis shows that, while not unprecedented, having a retired or active-duty military officer as MoD is relatively rare among democracies. The chapter concludes by e

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Som, Lalita. "Country case study 8: South Africa." In State Capitalism. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780192849595.003.0010.

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SOEs in South Africa form a significant part of certain vital industries that serve as inputs to other industries. They are indispensable in fulfilling the State’s developmental mission. Since the mid-2000s, the overall economic environment in South Africa has been shaped largely by the RET policy; infrastructure-led growth; the B-BBEE policy; the economic dominance of key SOEs; and by State-investment institutions, like the Public Investment Corporation. But the combination of these policies and strategies has led to many unintended adverse consequences. It helped in the emergence of a symbio

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"N." In The Oxford Companion To Irish Literature, edited by Robert Welch and Bruce Stewart. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780198661580.003.0014.

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Abstract Naboth’s Vineyard (1891), a novel by *Somerville and Ross, originating as a short story entitled ‘Slide Number 42’ in the Christmas number of the Lady’s Pictorial (1890), and their only full-length treatment of Irish village life. A melodramatic plot involves the frustrated love of Harriet Donovan for the handsome Rick O’Grady whom she earlier rejected to marry John Donovan. As President of the local *Land League branch, Donovan abuses his position in trying to drive a widow, Mrs Leonard, off a farm he covets. O’Grady, who loves Mrs Leonard’s daughter Ellen, comes to her aid but incur

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Тези доповідей конференцій з теми "IT-ret"

Imoisili, Patrick Ehi, and Tien Chien Jen. "Renewable Energy Technologies: Opportunities and Challenges for South Africa." In 2023 International Conference on Sustainable Engineering and Materials Development. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-rulyg5.

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One of Africa's biggest problems, which has an impact on its social and economic growth, is its lack of access to electricity. Due to its reliance on coal, South Africa (SA) has been acknowledged as one of the nations in Sub-Saharan Africa that has had difficulty developing its energy infrastructure. South Africa is the biggest emitter of carbon dioxide (CO2) in Africa due to its dependence on coal. The nation has been forced to switch to cleaner energy technologies like solar energy, wind energy, biomass energy, and hydropower. However, as South Africa made the move from an energy based on fo

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Islam, Mazharul, A. K. M. Sadrul Islam, and M. Ruhul Amin. "Small-Scale Decentralized Renewable Energy Systems for the Remote Communities of the Developing Countries." In ASME 2005 Power Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/pwr2005-50068.

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About 2 billion people of the world, mostly in rural areas of the developing countries, do not have access to grid-based electricity. The most critical factor affecting their livelihoods is access to clean, affordable and reliable energy services for household and productive uses. Under this backdrop, renewable and readily available energy from the nature can be incorporated in several proven renewable energy technology (RET) systems and can play a significant role in meeting crucial energy needs in these remote far flung areas. RETs are ideal as distributed energy source and they can be incor

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Schihl, John, Aaron W. Skiba, Campbell D. Carter, Amirreza Gandomkar, Jack Whitcomb, and Patton M. Allison. "Evaluating the Effect of Liquid Water and Steam on Jet Flame Physics." In ASME Turbo Expo 2023: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/gt2023-101575.

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Abstract The present research effort focuses on determining the effect of steam and liquid water addition on flame structure in preheated, premixed, piloted methane-air jet flames. The turbulent Reynolds Number (ReT) varied between 760 and 4,200, and two equivalence ratios (0.9 and 1.1) were considered. Planar laser-induced fluorescence (PLIF) imaging of OH radicals was performed via excitation of transitions in its A-X (0,0) band (near 311 nm). Flame surface density (FSD) and average progress variable maps (c−) were derived from those images, which facilitated analysis of the turbulent flame-

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Lewis, Benjamin, Jonah Leary, Cynthia Dickman, et al. "The NSF REU/RET Research on Energy Absorbing 3D Printed Polymer Structures." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70787.

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Energy absorption capability of structures with embedded pores depends upon the amount of voids present and their configurations/distributions. In this study, the energy absorption of acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA) structures with varying pore shapes and sizes are investigated. The research was performed by two teams comprised of High School/Middle School teachers and undergraduate students as part of National Science Foundation (NSF) sponsored Research Experience for Teacher (RET)/Research Experience for Undergraduates (REU) teams. ABS samples were fabricated

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NAKAMURA, Shin. "MONOCYTE/MACROPHAGE TISSUE FACTOR: ROLE OF ITS N-GLYCOSYLATED CARBOHYDRATE MOIETY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643286.

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Monocytes/macrophages and related cells are known to generate tissue factor (TF) , a membrane associated lipid-glycoprotein complex, following activation with LPS or other stimuli. Monkey (M. fuscata) mononuclear leukocytes (MNL, 3 × 106/ml) cultured with LPS (lµg/ml) in FCS-free RPMI medium were stimulated to produce the glycoprotein (TF-Apo). After a lag period of 2 h the TF-Apo production was initiated, and its accumulation reached the plateau after 12 h and then declined to approximately half of the maximum level after 24 h. A time course of the TF activity was strictly in accord with that

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Karbalaei, Alireza, Damla Turgut, Melissa Dagley, Eleazar Vasquez, and Hyoung J. Cho. "Collaborative Multidisciplinary Engineering Design Experiences in IoT (Internet of Things) for Teachers Through Summer Research Site Program." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-87491.

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The objective of the NSF RET (Research Experiences for Teachers) site program hosted by the University of Central Florida is to provide K-12 teachers with a hands-on engineering design experience covering all aspects of the Internet of Things, from the manufacturing of a sensor, to the hardware and software that allows it to connect to the Internet. This program gives teachers learning opportunities to explore the practical use of science for engineering applications, and provide a context in which students in their classroom can test their own scientific knowledge as they recognize the interp

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Harun, Zambri, Ashraf A. Abbas, and Bagus Nugroho. "Directional Surface Roughness Influence on Turbulent Flow Structure." In ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/ajkfluids2019-5615.

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Abstract A series of experiments have been conducted to investigate turbulent flow structures when it is exposed to a highly directional riblet-type surfaces roughness (converging-diverging/herringbone pattern) at a relatively low Reynolds number (Reτ). These experiments show that even at a low Reτ, the surface pattern is able to modify the turbulent boundary layer. Over the diverging region, we observe a decrease in drag penalty, while over the converging region there is an increase of drag penalty, which is indicated by the shift in the mean velocity profiles. The surface roughness also infl

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Grover, C. P. "Rainbow holography using external spatial filters for chromatic corrections." In OSA Annual Meeting. Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.thll4.

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A promising method using external spatial filters is described for the chromatic correction of images from transmission holograms produced in white light. The spatial corrective filter or screen represents a 1-D random diffuser and is characterized by the sinc function describing the Fourier transform of its amplitude transmittance. Holograms of nondiffuse or specularly reflecting objects, for which the far field diffraction pattern can be approximated to the delta function, have been considered for chromatic corrections by these spatial filters. However, the technique is also applicable to op

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AlSulaimani, Aysha Mubarak, Pradip Majumdar, Reem AlHammadi, and Badhria AlHammadi. "Centralized Predictive Analytics & Diagnostics Value Creation." In ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/211226-ms.

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Abstract The implemented maintenance strategy for rotating equipment in the field was conventional time-based (6months-1year) maintenance. Due to this maintenance philosophy, many equipment's were serviced every 6-12 months including the stand-by equipment. Thus, material, spare parts and man-hours are consumed very frequently. In 2019, company decided to convert the maintenance philosophy from time-based to running-hours based and based on OEMs recommendations, 4000 running-hours was the optimum running-hours before the equipment maintenance. By implementing this technique, the frequency of e

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Rakotonirina, Andriarimina Daniel, Martin Gonzalez, and Bruno Sainte-Rose. "On the Digital Twin of the Ocean Cleanup Systems." In ASME 2023 42nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/omae2023-103055.

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Abstract The Ocean Cleanup is introducing a Digital Twin (DT) describing the cleanup systems made with netted screens to concentrate marine litters and extract them from our oceans. Our DT aims at: i) avoiding over- or under-designing the system; ii) extrapolating from one system to a fleet of systems; and iii) estimating the costs of our offshore operations. These costs are evaluated as cost per kilogram of extracted plastic which is our Key Performance Indicator (KPI). One of the main contributing parameters to the KPI is the hydrodynamic load of our “U-shape” device that spans up to 630 met

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