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Готові списки джерел за темами / Key Words: Drug Eluting Stent (DES) / Статті в журналах

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Статті в журналах з теми "Key Words: Drug Eluting Stent (DES)"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Tinanda Tarigan, Daniel Sukmadja, Kaka Citta Prasiddha, and Rizkan Triatmaja. "Comparative efficacy of drug-eluting balloon and drug-eluting stent for treatment of in-stent restenosis: a systematic review and meta-analysis." Journal of the Pakistan Medical Association 74, no. 6 (Supple) (2024): S51—S56. http://dx.doi.org/10.47391/jpma.s6-acsa-09.

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Objective: To compare the efficacy of drug-eluting stents and drug-eluting balloons in treating in-stent restenosis. Method: The systematic review was conducted from January to February 2022, and comprised literature search on PubMed, ProQuest, Cochrane Library and Google Scholar databases with relevant key words to locate randomised controlled trials and observational studies published between 2000 and 2022 that compared drugeluting balloons and drug-eluting stents in the treatment of in-stent restenosis. The outcomes were all-cause death, cardiovascular death, major adverse cardiovascular ev

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2

Chong, Eric, Kian Keong Poh, Shen Liang, Xu Min Hou, and Huay Cheem Tan. "Eighteen-Month Clinical Safety and Efficacy Outcomes of Sirolimus-, Paclitaxel and Zotarolimus-drug Eluting Stents in Diabetic Patients Undergoing Percutaneous Coronary Intervention for Complex Coronary Artery Stenosis." Annals of the Academy of Medicine, Singapore 39, no. 5 (2010): 381–84. http://dx.doi.org/10.47102/annals-acadmedsg.v39n5p381.

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Introduction: This was a single centre registry study on clinical efficacy and safety of drug-eluting stent (DES) in diabetic patients undergoing percutaneous coronary intervention (PCI) for complex coronary lesions. Materials and Methods: A total of 288 diabetic patients who underwent elective PCI between September 2003 and June 2006 in our centre were enrolled and followed-up for 18 months. Among them, 79 (27.4%) patients received sirolimus-eluting stent (SES), 138 (47.9%) paclitaxel-eluting stent (PES) and 71 (24.7%) zotarolimus-eluting stent (ZES). The endpoints were major adverse cardiac

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3

Chandwani, Prakash, Bhavesh Meel, Rahul Singhal, et al. "Three-Year Outcomes of Biodegradable Polymer-Coated Ultra-Thin (60 µm) Sirolimus-Eluting Stents in Real-World Clinical Practice." Annals of the Academy of Medicine, Singapore 48, no. 5 (2019): 150–55. http://dx.doi.org/10.47102/annals-acadmedsg.v48n5p150.

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Introduction: Although drug-eluting stents (DES) have outclassed the use of bare metal stents, the safety and efficacy of DES at long-term follow-up has still been conflicting because of increased occurrence of late or very late restenosis and stent thrombosis after DES implantation. Hence, the present study was aimed to evaluate the 3-year safety and clinical performance of biodegradable polymer-coated ultra-thin (60 μm) sirolimus-eluting stent (SES) in real-world patients with coronary artery disease (CAD). Materials and Methods: This was a physician-initiated, retrospective, single-centre,

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4

Chetan, R. Patela* Mandev B. Patelb. "A study to compare Major Adverse Cardiac Event in patient undergoing PCI with Drug Eluting Stents Vs Bare Metal Stents." Journal of Pharma Research 1, no. 1 (2012): 12–15. https://doi.org/10.5281/zenodo.1098639.

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<strong><em>ABSTRACT</em></strong> <em>This study compared Major Adverse Cardiac Event in patient with Acute Coronary Syndromes undergoing PCI with Drug Eluting Stents Vs Bare Metal Stents. A retrospective, observational study was carried out in an inpatient setting of the private tertiary care hospital. Patients with >18 years, diagnosed for Acute Coronary Syndromes (ACS), required intervention in coronary artery with implantation of Drug Eluting Stents (DES) or Bare Metal Stents (BMS) were recruited in the study. The data had been collected from file or database of the hospital. All subje

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5

Liang, Michael, The Vun Liew, Aniket Puri, Lauren Hyde, and Gerard Devlin. "Medium to Long-Term Clinical Outcomes with Everolimus-Eluting Stents in Real-Life Percutaneous Coronary Intervention." Annals of the Academy of Medicine, Singapore 41, no. 6 (2012): 252–57. http://dx.doi.org/10.47102/annals-acadmedsg.v41n6p252.

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Introduction: Everolimus eluting stents (EES) have demonstrated excellent re-stenosis and thrombosis rates in a number of randomised controlled trials. This study reported the real world experience in a single tertiary centre with EES in predominantly acute coronary syndrome (ACS) patients and compared the outcomes in small and large vessels. We measured the medium to long-term major adverse cardiovascular events (MACE) defi ned as all-cause mortality, myocardial infarction (MI) and target vessel revascularisation (TVR) and stent thrombosis. Materials and Methods: All consecutive patients unde

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6

Yaneza, Liberty O., and Leah T. Verdillo. "Comparison of Drug Eluting Stents Versus Bare Metal Stents in Femoropopliteal Artery Occlusive Disease: A Systematic Review and Meta-analysis." Philippine Journal of Cardiology 40, no. 1 (2012): 13–21. http://dx.doi.org/10.69944/pjc.417b9d1162.

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OBJECTIVES: To compare the angiographic and clinical outcomes in patients who have undergone peripheral artery intervention using either drug eluting stents (DES) or bare metal stents (BMS). METHODS: A meta-analysis of randomized studies that compare DES and BMS in patients with femoropopliteal occlusive artery disease. RESULTS: Five clinical trials met the inclusion criteria. Results showed that using DES yielded a higher arterial patency rate (RR 1.41; 95% CI 1.23-1.61), reduced restenosis rate (RR 0.46; 95% CI 0.33-0.63), and had a lesser tendency for repeat revascularization (RR 0.29; 95%

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7

Jibran, Rushd, Junaid Alam Khan, and Angela Hoye. "Gender Disparity in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes – Does it Still Exist in Contemporary Practice?" Annals of the Academy of Medicine, Singapore 39, no. 3 (2010): 173–78. http://dx.doi.org/10.47102/annals-acadmedsg.v39n3p173.

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Introduction: Prior studies have demonstrated evidence of a disparity in the treatment and outcome of male compared to female patients undergoing percutaneous coronary intervention (PCI). Materials and Methods: From a dedicated database, we retrospectively analysed all consecutive patients with acute coronary syndrome (ACS) admitted to our institution for PCI in 2008. Baseline and procedural characteristics as well as complications were then evaluated for male patients (n = 331) as compared with female patients (n = 137). Results: Women were noted to be older at the time of presentation (66.1

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8

Mahmoud, Elsayed Abdelatif, Alakabawy Hazem, Fawzy Mohamed, and Fahmy Abdelraouf. "Comparison between coronary artery bypass surgery and percutaneous coronary intervention with drug-eluting stents for Egyptian diabetic patients with Multivessel disease." Biolife 5, no. 3 (2022): 295–302. https://doi.org/10.5281/zenodo.7364728.

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<strong>ABSTRACT</strong> <strong><em>Background: </em></strong>With the advances in the interventional field, the usage of DES make the choice of revascularization in diabetic patients with MVD controversial. <strong><em>Methods: </em></strong>We assigned patients with diabetes and MVD to undergo either PCI with DES or CABG. The patients were followed up for 12 months. The primary outcome was a composite of death, MI, repeated revascularization or stroke. <strong><em>Results: </em></strong>The study was conducted on 225 patients (116 patients randomly assigned to the PCI group and 109 randoml

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9

Hsiao, Hao Ming, Chun Ting Yeh, Tsung Yuan Wu, Li Wei Wu, Bor Hann Huang, and Hsiao Nan Yang. "Design and Manufacturing of Drug Eluting Depot Stents with Micro-Sized Drug Reservoirs." Applied Mechanics and Materials 479-480 (December 2013): 225–29. http://dx.doi.org/10.4028/www.scientific.net/amm.479-480.225.

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The effects of micro-sized through-hole drug reservoirs on several key clinical attributes of the drug eluting depot stent were investigated. Finite element models were developed to predict the mechanical integrity of a balloon-expandable stent at various stages such as manufacturing and deployment, as well as the stent radial strength and fatigue life. Results show that (1) creating drug reservoirs on a stent could impact the stent fatigue resistance to certain degrees, and (2) drug reservoirs on the stent crowns led to much greater loss in all key clinical attributes than reservoirs on other

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10

Allocco, Dominic J., Mary V. Jacoski, Barbara Huibregtse, Tim Mickley, and Keith D. Dawkins. "Platinum Chromium Stent Series – The TAXUS™ Element™ (ION™), PROMUS Element™ and OMEGA™ Stents." Interventional Cardiology Review 6, no. 2 (2011): 134. http://dx.doi.org/10.15420/icr.2011.6.2.134.

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Advances in drug-eluting stent technology have continued to improve clinical outcomes for patients undergoing percutaneous coronary intervention (PCI). The Boston Scientific stent platform has evolved from the 316L stainless steel Express™ stent, to the 316L stainless steel Liberté™ stent, to the cobalt–chromium PROMUS™ stent and, finally, to the platinum–chromium (PtCr) stent series. The PtCr platform, which uses the Element architecture, is designed to have improved deliverability, radiopacity, radial strength and recoil resistance compared with existing stainless steel or cobalt–chromium st

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11

Patel, Jatin Haribhai, and Dhavalkumar Patel. "Study the effect of fiber laser parameter on bending stifness of CoCr stent manufactured by fiber laser." International Journal of Mechanical Engineering Volume 7, January 2022 (2022): 5306–15. https://doi.org/10.5281/zenodo.5886612.

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Cardiovascular stent is a kind of mechanical device, which is chronically implanted into arteries in order to physically expand and scaffold blood vessels narrowed due to the plaque accumulation [1,2]. Firstly stent was made from waving the wire material. After words EDM and Laser Micro Machining was introduced for manufacturing stent. Many clinical research has been carried out on the bare metal stent and drug eluting stent. The perseverance of this research is to study about stent manufacturing using fiber laser machining parameters on Cobalt L-605 material. In this study contribution of fib

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12

Ali, Abdulmonam. "March 2024 Medical Image of the Month: Sputum Cytology in Patients with Suspected Lung Malignancy Presenting with Acute Hypoxic Respiratory Failure." Southwest Journal of Pulmonary, Critical Care & Sleep 28, no. 3 (2024): 30–31. http://dx.doi.org/10.13175/swjpccs008-24.

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No abstract available. Article truncated after 150 words. A 71-year-old woman presented with right-sided mass-like consolidation and pleural effusion on CT (Figure 1A), discovered incidentally after placement of a drug-eluting stent for coronary artery disease. The patient had a medical history significant for COPD, hypertension, hyperlipidemia, and coronary artery disease, status post a recent drug-eluting stent (less than 1 month ago). The patient received a presumptive diagnosis of pneumonia with parapneumonic effusion. Findings persisted despite multiple courses of empiric antibiotic thera

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13

Hsiao, Hao-Ming, Yi-Hsiang Chiu, Tsung-Yuan Wu, Jung-Keng Shen, and Ting-Yu Lee. "Effects of through-hole drug reservoirs on key clinical attributes for drug-eluting depot stent." Medical Engineering & Physics 35, no. 7 (2013): 884–97. http://dx.doi.org/10.1016/j.medengphy.2012.08.021.

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14

Suzy, Fawzi. "Glycosylated hemoglobin (HBA1c) levels as follow-up for clinical outcome (cardiac events) after coronary artery stenting in diabetic patients." Biolife 5, no. 4 (2022): 557–63. https://doi.org/10.5281/zenodo.7393268.

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<strong>ABSTRACT</strong> Diabetes mellitus (DM) has  been recognized to be  a strong risk factor  for cardiovascular disease (CVD) and has been proved to be an independent risk factor for in-stent restenosis. After stent implantation, restenosis remains the “Achilles’ heel” of percutaneous coronary intervention (PCI) and diabetic patients compared to non-diabetics still have poorer clinical outcomes. Objective:(Aim of Work)  is to evaluate whether the level of  HbA1c - as an  indicator  for   the glycaemic control in diabetic pati

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15

Kim, Yonghee, Kyusup Lee, and Sung-Ho Her. "Clinical Outcomes of Rotational Atherectomy in the Drug-Eluting Stent Era." Journal of Clinical Medicine 14, no. 7 (2025): 2199. https://doi.org/10.3390/jcm14072199.

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Background: The increasing prevalence of severe calcified coronary artery disease has expanded the role of rotational atherectomy (RA) in percutaneous coronary intervention (PCI). In the drug-eluting stent (DES) era, RA remains a key tool for complex lesion modification. This review focuses on its clinical outcomes and evolving indications. Methods: This review was conducted as a narrative review, focusing on the most relevant clinical studies regarding RA in the DES era. Articles were identified through a systematic PubMed search. Results: Comparing to early-generation DES, new-generation DES

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16

Cahoon, William D., Allison K. Oswalt, Kerry E. Francis, Lauren C. Magee, and Denise K. Lowe. "Cangrelor Bridge Therapy for Gastroduodenal Biopsy." Journal of Pharmacy Practice 30, no. 2 (2016): 270–73. http://dx.doi.org/10.1177/0897190016636750.

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Dual antiplatelet therapy (DAPT) is the key for secondary prevention of acute coronary syndromes and percutaneous coronary intervention with stent placement. Premature discontinuation of DAPT can result in an increase in cardiac ischemic events and death. If early interruption of DAPT for urgent procedures or surgery is necessary, then ischemic and bleed risks must be balanced with bridging therapy. To date, no medications have a Food and Drug Administration indication for antiplatelet bridge therapy. We present a case of a woman with a history of gastrointestinal bleeding on DAPT for a drug-e

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17

Jackson, Caitlin E., Liam S. J. Johnson, Dominic A. Williams, Hans-Ulrich Laasch, Derek W. Edwards, and Alison G. Harvey. "A viewpoint on material and design considerations for oesophageal stents with extended lifetime." Journal of Materials Science 57, no. 1 (2022): 3–26. http://dx.doi.org/10.1007/s10853-021-06700-9.

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AbstractOesophageal stents are meshed tubular implants designed to maintain patency of the oesophageal lumen and attenuate the symptoms of oesophageal cancer. Oesophageal cancers account for one in twenty cancer diagnoses and can lead to dysphasia, malnutrition and the diminishment of patient quality of life (QOL). Self-expanding oesophageal stents are the most common approach to attenuate these symptoms. Recent advances in oncological therapy have enabled patient survival beyond the lifetime of current devices. This introduces new complications for palliation, driving the need for innovation

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18

Noad, Rebecca L., Colm G. Hanratty, and Simon J. Walsh. "Clinical Impact of Stent Design." Interventional Cardiology Review 9, no. 2 (2011): 89. http://dx.doi.org/10.15420/icr.2011.9.2.89.

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The introduction and widespread adoption of drug-eluting stents into routine clinical practice has seen tremendous changes in the practice of interventional cardiology. For a prolonged period, manufacturers have focused research on drugs and polymers that are the key to the prevention of in-stent restenosis. However, stent platform design and its clinical implications have now come back to the fore. This has occurred for numerous reasons, but has primarily been driven by the need for modern stents to perform well in increasingly demanding clinical scenarios. This paper reviews the historical e

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19

Murasato, Yoshinobu, Kyohei Meno, Takahiro Mori, and Katsuhiko Tanenaka. "Impact of coronary bifurcation angle on the pathogenesis of atherosclerosis and clinical outcome of coronary bifurcation intervention–A scoping review." PLOS ONE 17, no. 8 (2022): e0273157. http://dx.doi.org/10.1371/journal.pone.0273157.

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Background A coronary bifurcation stenting is still a challenging issue due to frequent restenosis and stent thrombosis even with drug-eluting stents. The bifurcation angle (BA) between a main vessel and a side branch is one of the crucial determinants of coronary flow and shear stress that affect the plaque distribution. Previous bench and clinical studies have evaluated the impact of the BA between the proximal main vessel and the side branch (Angle A) and the BA between the distal main vessel and the side branch (Angle B) on the clinical outcomes of bifurcation stenting. However, the impact

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20

Cijy, John Akash Jose Kollanassery* Venkateshwaran S. Blessy Cherian Aiswarya Wilson. "Intracerebral Hemorrhage Complicating Post-Angioplasty in a Hypertensive Patient on Dual Antiplatelet Therapy: A Case Report." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3260–64. https://doi.org/10.5281/zenodo.15464705.

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Dual antiplatelet therapy (DAPT) with an oral P2Y12 antagonist and Aspirin is a key therapeutic approach in patients with post-angioplasty for acute myocardial infarction. DAPT provides more significant platelet inhibition, leading to a gradual decrease in the risk of major adverse cardiac events, particularly recurrent ischemic events such as myocardial infarction, including stent thrombosis, ischemic stroke, or death from cardiac cause. Although intracerebral hemorrhage (ICH) is a hidden negative side of Antiplatelet therapy (APT), its incidence is relatively low. Here, we present a case of

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21

Mandal, Akash Pradip, and Prashanta Kumar Mandal. "Two-phase binding of drug in a three-layered arterial wall following stent implantation." Physica Scripta 97, no. 4 (2022): 045004. http://dx.doi.org/10.1088/1402-4896/ac58cc.

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Abstract The present study explores the distribution and the binding of drug eluted from an embedded drug-eluting stent (DES), having struts of the circular cross-section. The arterial tissue is composed of three distinct layers, namely, the intima, the media and the adventitia, with varying diffusivity, and at the interfaces between different layers, a jump condition is imposed. The transport of free drug is modelled by the convection–diffusion-reaction process while the binding of drug is modelled by a nonlinear saturable reversible chemical reaction only. This model incorporates two types o

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22

Koganti, Sudheer, Tushar Kotecha, and Roby D. Rakhit. "Choice of Intracoronary Imaging: When to Use Intravascular Ultrasound or Optical Coherence Tomography." Interventional Cardiology Review 11, no. 1 (2016): 11. http://dx.doi.org/10.15420/icr.2016.11.01.11.

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Intracoronary imaging has the capability of accurately measuring vessel and stenosis dimensions, assessing vessel integrity, characterising lesion morphology and guiding optimal percutaneous coronary intervention (PCI). Coronary angiography used to detect and assess coronary stenosis severity has limitations. The 2D nature of fluoroscopic imaging provides lumen profile only and the assessment of coronary stenosis by visual estimation is subjective and prone to error. Performing PCI based on coronary angiography alone is inadequate for determining key metrics of the vessel such as dimension, ex

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23

Koganti, Sudheer, Tushar Kotecha, and Roby D. Rakhit. "Choice of Intracoronary Imaging: When to Use Intravascular Ultrasound or Optical Coherence Tomography." Interventional Cardiology Review 11, no. 1 (2016): 11. http://dx.doi.org/10.15420/icr.2016:6:1.

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Intracoronary imaging has the capability of accurately measuring vessel and stenosis dimensions, assessing vessel integrity, characterising lesion morphology and guiding optimal percutaneous coronary intervention (PCI). Coronary angiography used to detect and assess coronary stenosis severity has limitations. The 2D nature of fluoroscopic imaging provides lumen profile only and the assessment of coronary stenosis by visual estimation is subjective and prone to error. Performing PCI based on coronary angiography alone is inadequate for determining key metrics of the vessel such as dimension, ex

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24

McEntegart, Margaret B., and Keith G. Oldroyd. "Functional Revascularisation – The Key to Improving Percutaneous Coronary Intervention Outcomes." European Cardiology Review 5, no. 1 (2009): 63. http://dx.doi.org/10.15420/ecr.2009.5.1.63.

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Recent coronary revascularisation trials have questioned the benefit of percutaneous coronary intervention (PCI) over medical therapy in chronic stable angina (CSA) and its non-inferiority to coronary artery bypass grafting (CABG) in left main and three-vessel coronary disease. This raises the question of how to further improve PCI outcomes in the drug-eluting stent era. The Fractional Flow Reserve (FFR) versus Angiography for Multivessel Evaluation (FAME) study has shown that PCI guided by FFR, rather than by angiography alone, reduces major adverse cardiac events (MACE). This suggests that r

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25

Fluder-Wlodarczyk, Joanna, Zofia Schneider, Tomasz Pawłowski, Wojciech Wojakowski, Pawel Gasior, and Elżbieta Pociask. "Assessment of Effectiveness of the Algorithm for Automated Quantitative Analysis of Metallic Strut Tissue Short-Term Coverage with Intravascular Optical Coherence Tomography." Journal of Clinical Medicine 13, no. 15 (2024): 4336. http://dx.doi.org/10.3390/jcm13154336.

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Background: Due to its high resolution, optical coherence tomography (OCT) is the most suitable modality for neointimal coverage assessments. Evaluation of stent healing seems crucial to accurately define their safety profile since delayed healing is connected with stent thrombosis. This study aimed to present an algorithm for automated quantitative analysis of stent strut coverage at the early stages of vessel healing in intravascular OCT. Methods: A set of 592 OCT frames from 24 patients one month following drug-eluting stent implantation was used to assess the algorithm’s effectiveness. Str

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26

Khashaba, Ahmed, Roberto Garbo, Kurstat Tigen, Helge Moellmann, and Marie-Claude Morice. "Absorbable Polymer Technology – Viable Solutions for Unmet Needs in PCI." Interventional Cardiology Review 10, no. 3 (2015): 162. http://dx.doi.org/10.15420/icr.2015.10.03.162.

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The use of drug-eluting stents (DES) has improved clinical outcomes in percutaneous coronary intervention procedures, but many challenges remain. In two symposia at EuroPCR 2015, the factors necessary to ensure successful chronic total occlusion (CTO) intervention were presented. Good preparation, sufficient operator experience and the correct approach are key to the success of CTO interventions. A live case demonstrated the challenges of these complex cases. Stent choice in CTO interventions is crucial; second-generation DES are associated with lower rates of restenosis and re-occlusion compa

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27

Tona, Azwar Iwan. "Percutaneous Coronary Intervention Literature Review." Journal of Society Medicine 3, no. 9 (2024): 266–69. https://doi.org/10.47353/jsocmed.v3i9.172.

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This literature review examines the advancements and outcomes associated with Percutaneous Coronary Intervention (PCI), a minimally invasive procedure widely utilized to treat coronary artery disease. The review highlights key studies that evaluate the efficacy and safety of PCI, comparing it to traditional surgical options such as coronary artery bypass grafting (CABG). It explores the evolution of PCI techniques, including drug-eluting stents and optical coherence tomography, and their impact on patient outcomes, including rates of restenosis and major adverse cardiovascular events. Stents s

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28

Zhu, Min, Minjun Yang, Jiangbo Lin, et al. "Association of seven renin angiotensin system gene polymorphisms with restenosis in patients following coronary stenting." Journal of the Renin-Angiotensin-Aldosterone System 18, no. 1 (2017): 147032031668877. http://dx.doi.org/10.1177/1470320316688774.

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Background and objective: Percutaneous coronary intervention, despite being effective for coronary revascularization, causes in-stent restenosis due to neointimal hyperplasia in a large number of patients. The renin-angiotensin system is involved in neointimal hyperplasia. This study sought to evaluate seven gene polymorphisms of key renin-angiotensin system components, including angiotensinogen, angiotensin-converting enzyme and angiotensin II type 1a receptors, and their associations with in-stent restenosis in patients with coronary artery disease following coronary stenting. Methods and re

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Yu, Xing, Jian-Yi Zheng, and Gui-Ping Zhu. "Successful treatment of left main coronary artery total occlusion combined with cardiogenic shock." Journal of International Medical Research 47, no. 8 (2019): 3940–45. http://dx.doi.org/10.1177/0300060519860681.

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Acute myocardial infarction (AMI) caused by total occlusion of the left main coronary artery (LMCA) is a catastrophic event. However, the clinical features and appropriate treatment of patients with this condition remain unclear. We report a man with total occlusion of the LMCA presenting with AMI combined with cardiogenic shock. He was successfully treated with angioplasty and drug-eluting stent implantation assisted by an intra-aortic balloon pump (IABP). This case suggests that percutaneous coronary intervention may be an optional therapeutic strategy in these patients, and that IABP implan

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Touchard, Arturo G., and Robert S. Schwartz. "Preclinical Restenosis Models: Challenges and Successes." Toxicologic Pathology 34, no. 1 (2006): 11–18. http://dx.doi.org/10.1080/01926230500499407.

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Анотація:

Coronary artery disease remains a major problem for Western societies. The advent of percutaneous interventions, including stents has brought clinical care to a new level of efficacy, yet problems remain. Restenosis following stenting in human coronary arteries appears at last to be yielding to therapeutic strategies, especially drug eluting stents. Because therapeutic percutaneous coronary intervention is widely dominated by the intracoronary stent, restenosis therapies must include the stented coronary artery. Animal models and in particular the porcine coronary model seem to represent the h

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Xu, Bo, Run-lin Gao, Rui-yan Zhang, et al. "Efficacy and safety of FIREHAWK® abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial long cohort." Chinese Medical Journal 126, no. 6 (2013): 1026–32. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20123206.

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Background Previous studies indicated that long coronary lesions are one of the key predictors of drug-eluting stent (DES) failure. The purpose of this study was to evaluate the efficacy and the safety of the long length FIREHAWK® stent in long coronary artery disease. Methods The long cohort of TARGET I was a prospective, multicenter, single arm trial. It was planned to enroll 50 patients undergoing percutaneous coronary intervention (PCI) for the treatment of de novo long lesions in a native coronary artery. The major inclusion criteria of the trial was that patients were intended to undergo

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Ferenț, Ionuț, István Benedek, Alina Corduneanu, András Mester, Theodora Benedek, and Imre Benedek. "In-stent Flow Hemodynamics and the Risk of STent Failure Following Bioresorbable Vascular ScAFFolds Implantation – the STAFF Study." Journal of Interdisciplinary Medicine 2, no. 4 (2017): 320–23. http://dx.doi.org/10.1515/jim-2017-0091.

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AbstractBackground:Myocardial revascularization procedures have undergone important developments over the last decades, which led to a major shift in current clinical practice and therapeutic guidelines across the world. Bare metal and drug-eluting stents present several limitations, all centered on the concept of disturbed coronary hemodynamics after implantation, which can be surpassed by bioresorbable vascular scaffolds (BVS). BVSs are fourth-generation stents used in coronary revascularization procedures, but despite all the promising initial results published on their efficiency, several

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Tanajura, Luiz, Áurea Chaves, Rafaela Freitas, Ana Barbosa, Kelvyn Vital, and José Delamain. "Aspirin versus P2Y12 inhibitors for secondary prevention after percutaneous coronary intervention." Journal of Transcatheter Interventions 31 (December 14, 2023): 1–7. http://dx.doi.org/10.31160/jotci202331a202304.

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Currently, percutaneous coronary intervention with a drug-eluting stent implantation is the main method of myocardial revascularization in tertiary care hospitals, regardless of the clinical presentation of coronary artery disease. It is well known that to be effective, it requires the use of a dual antiplatelet therapy, which is a combination of acetylsalicylic acid and a P2Y12 platelet receptor inhibitor, which plays a key role in preventing thromboses after endoprosthesis implantation and is also indicated to prevent atherothrombotic events in the late clinical course, regardless of the ste

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König, Sarah, Sara Browne, Bernhard Doleschal, et al. "Inhibition of Orai1-mediated Ca2+ entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle." American Journal of Physiology-Heart and Circulatory Physiology 305, no. 11 (2013): H1646—H1657. http://dx.doi.org/10.1152/ajpheart.00365.2013.

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Sirolimus (rapamycin) is used in drug-eluting stent strategies and proved clearly superior in this application compared with other immunomodulators such as pimecrolimus. The molecular basis of this action of sirolimus in the vascular system is still incompletely understood. Measurements of cell proliferation in human coronary artery smooth muscle cells (hCASM) demonstrated a higher antiproliferative activity of sirolimus compared with pimecrolimus. Although sirolimus lacks inhibitory effects on calcineurin, nuclear factor of activated T-cell activation in hCASM was suppressed to a similar exte

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Bhat, Salman, Yan Yatsynovich, and Umesh C. Sharma. "Coronary revascularization in patients with stable coronary disease and diabetes mellitus." Diabetes and Vascular Disease Research 18, no. 2 (2021): 147916412110024. http://dx.doi.org/10.1177/14791641211002469.

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Purpose of Study: Diabetes mellitus accelerates the development of atherosclerosis. Patients with diabetes mellitus have higher incidence and mortality rates from cardiovascular disease and undergo a disproportionately higher number of coronary interventions compared to the general population. Proper selection of treatment modalities is thus paramount. Treatment strategies include medical management and interventional approaches including coronary artery bypass graft (CABG) surgery and percutaneous coronary interventions (PCI). The purpose of this review is to assimilate emerging evidence comp

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Mitsios, Alexandros, Akrivi Chrysanthopoulou, Athanasios Arampatzioglou, et al. "Ticagrelor Exerts Immune-Modulatory Effect by Attenuating Neutrophil Extracellular Traps." International Journal of Molecular Sciences 21, no. 10 (2020): 3625. http://dx.doi.org/10.3390/ijms21103625.

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Neutrophils through the release of neutrophil extracellular traps (NETs) containing active tissue factor (TF) are key components of thrombo-inflammation. Platelets-neutrophils interplay in ST elevation myocardial infarction (STEMI) promotes NET formation via inorganic polyphosphates (polyP) released by thrombin-activated platelets. NETs, however, are also induced by biomaterials in a platelet-independent manner. Considering the possible pleiotropic effects of Ticagrelor beyond platelet inhibition and the clinical need for novel antithrombotic strategies targeting inflammation, we investigated

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Bosch, Aniol, Enric Casanova-Batlle, Iuliana Constantin, Carles Rubio, Joaquim Ciurana, and Antonio J. Guerra. "An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters." Polymers 15, no. 21 (2023): 4298. http://dx.doi.org/10.3390/polym15214298.

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In the last decades, researchers have been developing bioresorbable stents (BRS) to overcome the long-term complications of drug-eluting stents (DES). However, BRS technology still presents challenging limitations in terms of manufacturing, materials, or mechanical properties. At this juncture, companies have developed ultrathin DES that may further improve the efficacy and safety profile of traditional DES by reducing the risk of target-lesion and target-vessel failures until BRS are developed. Nonetheless, the metallic platform of ultrathin DES still presents problems related to their cellul

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Poder, Thomas, Jihane Erraji, Lucien Coulibaly, et al. "PP166 From An Institutional Strategic Plan To A Knowledge Transfer Tool For Health Technology Assessment: Case Of Drug-eluting Stents." International Journal of Technology Assessment in Health Care 33, S1 (2017): 142–43. http://dx.doi.org/10.1017/s0266462317002963.

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INTRODUCTION:Knowledge transfer (KT) of Health Technolgy Assessment (HTA) results presents numerous challenges, one being the lack of time of busy decision makers. Our hospital-based HTA unit is now part of a large network comprising 100 installations. To bridge the gap between complex HTAs and even more limited time by executive officers and managers, we needed to develop a new approach to deliver effectively key HTA messages. We initiated a new strategy with a report on drug-eluting stent (DES). DES may have the potential to eradicate restenosis and the necessity to perform multiple revascul

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Tamborrino, P., C. Vitale, M. Angelillis, G. Galeotti, and M. Carluccio. "DISCONTINUING DAPT: NOT JUST A MATTER OF SCORES BUT OF INTEGRATED EVALUATION? A KEY ROLE OF IMAGING IN A COMPLEX SCENARIO." European Heart Journal Supplements 26, Supplement_2 (2024): ii113—ii114. http://dx.doi.org/10.1093/eurheartjsupp/suae036.283.

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Abstract The duration of the dual antiplatelet therapy (DAPT) is a widely debated topic within the scientific community. The latest guidelines on acute coronary syndromes have supported the possibility of different therapeutic approaches tailored to patient characteristics. However, the clinical cardiologist‘s decisions are not always based on certain principles. The following case report is a practical example. Discussion: A 31–years–old man came to our attention after a resuscitated cardiac arrest due to ventricular fibrillation during a motorcycle race. His history was characterized by a pr

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Aksenov, Evgen V., Artem Yu Hladun, and Sviatoslav A. Kalashnikov. "Coronary Angioplasty with a Drug-Coated Balloon Catheter in the Treatment of Acute Coronary Syndromes: Medico-Social Perspectives and Challenges of Use in the Setting of Diffuse Coronary Artery Lesions — A Literature Review." Ukrainian Journal of Cardiovascular Surgery 33, no. 2 (2025): 18–22. https://doi.org/10.63181/ujcvs.2025.33(2).18-22.

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This literature review explores the role of drug-coated balloon (DCB) angioplasty in the management of acute coronary syndromes (ACS), with a particular focus on patients with diffuse coronary artery disease. Aim. To conduct a literature review on the benefits of using DCB in the treatment of patients with diffuse coronary artery disease and ACS. Materials and methods. Unlike traditional drug-eluting stents (DES), DCB technology delivers antiproliferative drugs directly to the lesion site without leaving behind a permanent implant, offering significant advantages such as reduced risk of in-ste

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Hamanaka, Ichiro, Hiroaki Fujie, Madoka Ida, and Kinzo Ueda. "AS-113: Stenting Strategy in Left Main Trunk Disease in the Drug-Eluting Stent Era. Key Role of Single-Stenting with Selected Use of Bare Metal Stents under Intravascular Ultrasound Guidance." American Journal of Cardiology 103, no. 9 (2009): 50B—51B. http://dx.doi.org/10.1016/j.amjcard.2009.01.164.

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Cha, Jung-Joon, Soon Jun Hong, Subin Lim, et al. "The Use of Coronary Imaging for Predicting Future Cardiovascular Events." Pulse 12, no. 1 (2024): 34–39. http://dx.doi.org/10.1159/000538044.

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Background: Despite advancements in coronary artery disease (CAD) treatment with drug-eluting stent, its morbidity and mortality remain high. In context, intravascular imaging-guided percutaneous coronary intervention (PCI) is increasingly recommended for better clinical outcomes in patient with CAD. Near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), as one of the intravascular imaging methods, is effective in detecting lipid-rich plaques, which is crucial for identifying high-risk or vulnerable plaques employing near-infrared light. High lipid core burden, as identified by NIRS-

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Lecompte, Thomas P., Chantal Lecrubier, Cyril Bouloux, et al. "Antiplatelet Effects of the Addition of Acetylsalicylic Acid 40 Mg Daily to Ticlopidine in Human Healthy Volunteers." Clinical and Applied Thrombosis/Hemostasis 3, no. 4 (1997): 245–50. http://dx.doi.org/10.1177/107602969700300405.

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Clinical studies have shown that acetylsalicylic acid (ASA) or ticlopidine (T) bring a partial clinical benefit in a subset of patients threatened by thrombosis on atherosclerotic plaques. Acetylsalicylic acid and T have different impacts on platelet function and the combination of the drugs seems logical to achieve a greater antiplatelet effect. Healthy volunteers were randomly allocated to any of the three treatment groups: T 250-placebo; T 250-T 250; placebo-placebo (treatment was administered in a double blind manner). Acetylsalicylic acid 40 mg was openly administered once a day to the su

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Ali, Akhtar, Imran Bajwa, and Rafaqat Kazmi. "High-Performance Simulation of Drug Release Model Using Finite Element Method with CPU/GPU Platform." JUCS - Journal of Universal Computer Science 25, no. (10) (2019): 1261–78. https://doi.org/10.3217/jucs-025-10-1261.

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his paper describes a hybrid CPU/GPU approach for solving a two-phase mathematical model numerically. The dynamic of drug release between the first phase (coating) and second phase (arterial tissue) is represented by a system of partial differential equations (PDEs). The system of equations is discretized by Finite Element Method. The whole discretized system involves a large sparse system of equation which requires a high computation. The CPU/GPU approach provides a platform to solve PDEs having extensive computations in parallel. Consequently, this platform can significantly reduce the solut

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Li, Mingkang, Wenkang Zhang, Minhao Zhang, and Chengchun Tang. "ASSOCIATION BETWEEN THE ATHEROGENIC INDEX OF PLASMA AND ADVERSE LONG-TERM PROGNOSIS IN PATIENTS DIAGNOSED WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME." Journal of Hypertension 42, Suppl 1 (2024): e182. http://dx.doi.org/10.1097/01.hjh.0001021244.74455.12.

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Objective: Dyslipidemia is a key risk factor for coronary artery disease, and the atherogenic index of plasma (AIP) is a newly identified biomarker associated with lipid metabolism. However, none has addressed the association between AIP and clinical outcome in non-ST elevation acute coronary syndrome (NSTE-ACS) patients firstly implanted with drug-eluting stent (DES). Thus, we sought to evaluate the relationship between AIP and long-term prognosis in NSTE-ACS patients. Design and method: A total of 830 patients diagnosed with NSTE-ACS and who underwent DES were included in this study. The AIP

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Atallah, Joseph. "Use of Eptifibatide as a Bridge Antiplatelet Agent for Intrathecal Drug Delivery System Placement." Pain Physician 6;15, no. 6;12 (2012): 479–83. http://dx.doi.org/10.36076/ppj.2012/15/479.

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Use of antiplatelet agents is becoming increasingly common, and their management may require new strategies if neuroaxial techniques are to be employed in patients who will not tolerate discontinuation of antiplatelet therapy. The patient was a 46-year-old man with a past medical history significant for coronary artery disease and who had undergone 14 stents. He developed stent thrombosis (ST) while on clopidogrel. Following the ST, he was subsequently placed on prasugrel. While on prasugrel, the patient presented for an intrathecal drug delivery system (IDDS) trial and placement due to severe

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Wójcik, Justyna, Karolina Obuchowska, Aleksandra Obuchowska, et al. "Sudden cardiac arrest as a result of anterior and lateral myocardial infarction at 16 weeks of gestation - case report." Journal of Education, Health and Sport 10, no. 8 (2020): 428–33. https://doi.org/10.12775/JEHS.2020.10.08.052.

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<strong>Wójcik Justyna, Obuchowska Karolina</strong><strong>, Obuchowska Aleksandra, Ozga Alicja, Standyło Arkadiusz, </strong><strong>Kimber-Trojnar Żaneta</strong><strong>, Leszczyńska-Gorzelak Bożena</strong><strong>. </strong><strong>Sudden cardiac arrest</strong><strong> as a result of anterior and lateral myocardial infarction at 16 weeks of gestation - case report. Journal of Education, Health and Sport.</strong><strong> 2020;10(8):428</strong><strong>‑</strong><strong>433</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2020.10.08.052</stro

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Varotto, L., A. Dotto, S. Maisenti, et al. "NEW–ONSET RIGHT BUNDLE BRANCH BLOCK AND TRANSIENT ST–SEGMENT ELEVATION INDUCED BY TRANSCUTANEOUS AORTIC VALVE IMPLANTATION: A DISTINCT ELECTROCARDIOGRAPHIC AND CLINICAL CASE. KEY WORDS: LMCA OCCLUSION, TAVI, RIGHT BUNDLE BRANCH BLOCK." European Heart Journal Supplements 27, Supplement_5 (2025). https://doi.org/10.1093/eurheartjsupp/suaf076.204.

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Abstract Background The occurrence of left bundle branch block (LBBB) during transcutaneous aortic valve implantation (TAVI) has an incidence of 5 to 65% and is due to mechanical damage to the conduction system, while the right bundle branch block (RBBB) or left posterior hemiblock (LPH) are very rare and associated with myocardial ischemia. The right bundle branch receives its blood supply from anterior descending coronary artery. Acute left main coronary artery (LMCA) occlusion during TAVI is a life–threatening complication, with an incidence of 0.6% but a 30–day mortality rate of up to 50%.

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Dash, Dr S. K. Narayan, and Dr R. V. Vijay Bhaskar. "SUCCESSFUL STENTING OF ECTATIC CORONARY ARTERY WITH TWO DRUG ELUTING STENTS IN A PATIENT WITH ACUTE CORONARY SYNDROME." International Journal of Medical and Biomedical Studies 3, no. 10 (2019). http://dx.doi.org/10.32553/ijmbs.v3i10.691.

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Coronary artery ectasia is characterized by enlargement of the coronary artery 1.5 times or more than the normal artery. It can be found in 3-8% of persons undergoing coronary angiography and 1-2% of autopsy cases1. Coronary artery ectasia patients could be asymptomatic but some patients may present with exertional chest pain, acute coronary syndrome or sudden cardiac death2. Currently there is no clear cut guideline to treat stenotic coronary artery ectasia because of various sizes and types of coronary artery ectasia. Herein we report a 66 year old female presented with persistent chest pain

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Vijayaratnam, Pujith Rajaguru Senapathy, John Arthur Reizes, and Tracie Jacqueline Barber. "The impact of strut profile geometry and malapposition on the haemodynamics and drug-transport behaviour of arteries treated with drug-eluting stents." International Journal of Numerical Methods for Heat & Fluid Flow, May 24, 2022. http://dx.doi.org/10.1108/hff-03-2022-0145.

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Purpose Stent malapposition is one of the most significant precursors of stent thrombosis and restenosis. Adverse haemodynamics may play a key role in establishing these diseases, although numerical studies have used idealised drug transport models to show that drug transport from malapposed drug-eluting stent struts can be significant. This paper aims to study whether drug transport from malapposed struts is truly significant. Another aim is to see whether a streamlined strut profile geometry – with a 61% smaller coating but a 32% greater coating-tissue contact area – can mitigate the adverse

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