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Готові списки джерел за темами / Key Words: xenobiotics / Статті в журналах

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Статті в журналах з теми "Key Words: xenobiotics"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Madhukar., A1 Swathi. E1* S. Pranathi1 Vineela Devi1 K. Surender Reddy2. "Analysis of Xenobiotics: A Review." Journal of Pharma Research 1, no. 1 (2012): 5–11. https://doi.org/10.5281/zenodo.1098647.

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<strong><em>ABSTRACT</em></strong> <em>A xenobiotic is a </em><em>chemical which is found in an organism but which is not normally produced or expected to be present in it. It can also cover substances which are present in much higher concentrations than are usual. This study deals with the analysis of xenobiotics in detail including the concepts like Xenobiotic Metabolism(Xenobiotic Biotransformation), Rapid analysis of pharmaceuticals and excreted xenobiotic and endogenous metabolites with atmospheric pressure infrared MALDI mass spectrometry , De

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2

Palmisano, Anna C., Burney S. Schwab, Dorothy A. Maruscik, and Roy M. Ventullo. "Seasonal changes in mineralization of xenobiotics by stream microbial communities." Canadian Journal of Microbiology 37, no. 12 (1991): 939–48. http://dx.doi.org/10.1139/m91-162.

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Seasonal changes in the mineralization of mixed amino acids (MAA), an anionic surfactant (linear alkylbenzene sulfonate; LAS), a detergent builder (nitrilotriacetic acid; NTA), and a herbicide (2,4-dichlorophenoxyacetic acid; 2,4-D) by microbial communities were studied in two streams in southwestern Ohio. Radiolabeled (14C) test compounds were added to samples of seston, leaf litter, periphyton, and sediment collected from Briarly Creek, a waste water impacted stream, and Little Indian Creek, a relatively unimpacted stream. Mean values for NH3, orthophosphate, dissolved organic carbon, and to

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3

A. Aziz, Tavga, Zheen A. Ahmed, Kasim M. Juma'a, Munaf H. Abdulrazzaq, Saad A. Hussain, and Saad A. Hussain. "Study of the Protective Effects of Benfotiamine Against CCl4-Induced Hepatotoxicity in Rats." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, Suppl. (2017): 47–53. http://dx.doi.org/10.31351/vol18isssuppl.pp47-53.

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Liver is considered as the first target for the toxic effects of toxins and other xenobiotics, and this can be attributed to its role as a site which receive all absorbed xenobiotics from the gastrointestinal tract and its role as a major site for biotransformation of xenobiotics. The present study was designed to evaluate the possible hepatoprotective effect of benfotiamine against CCl4-induced hepatotoxicity in rats. The study was conducted on 48 male albino rats; the animals were allocated into 8 groups (6 rats in each group) and treated as follow: 4 groups treated with oral doses of either

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4

Foster, B. C., D. L. Litster, J. Zamecnik, and R. T. Coutts. "The biotransformation of tranylcypromine by Cunninghamella echinulata." Canadian Journal of Microbiology 37, no. 10 (1991): 791–95. http://dx.doi.org/10.1139/m91-136.

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When incubated alone for 7 days with the fungus Cunninghamella echinulata, tranylcypromine was extensively metabolized. As observed in mammalian systems, N-acetyltranylcypromine was the major metabolite recovered along with lesser amounts of 4-hydroxytranylcypromine, as its N,O-diacetyl derivative. The rate and extent of tranylcypromine biotransformation was affected by whether incubation was on either 30° or flat brackets with a gyratory shaker. There is a strong association between the rate of biotransformation and the utilization of glucose, formation of ammonia, and pH. The slowest rates o

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5

Dyman, T. "Xenoestrogens of anthropogenic origin in food products and their impact on human health." Tehnologìâ virobnictva ì pererobki produktìv tvarinnictva, no. 1 (186) (May 24, 2024): 116–26. http://dx.doi.org/10.33245/2310-9289-2024-186-1-116-126.

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The anthropogenic impact on the biosphere has now acquired a global character, resulting in a massive inﬂux of industrial, agricultural, and household waste into the environment. Numerous chemical, physical and biological substances present in the environment have a harmful effect on human health. Among them, a special group is formed by hormonally active xenobiotics – xenoestrogens. They are not produced by the body, but are structurally or functionally related to the human sex hormone 17β-estradiol, and bind to estrogen receptors with varying degrees of afnity and selectivity. The article su

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6

Bibbins-Martínez, M., J. Juárez-Hernández, J. Y. López-Domínguez, et al. "Potential application of fungal biosorption and/or bioaccumulation for the bioremediation of wastewater contamination: A review." Journal of Environmental Biology 44, no. 2 (2023): 135–45. http://dx.doi.org/10.22438/jeb/44/2/mrn-5093.

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The environment pollution or contamination is a serious problem, a great deal of research is being undertaken to combat contaminants such as xenobiotic and recalcitrant compounds, particularly heavy metals, dyes,phenolic compounds and other recalcitrant pollutants produced by a wide range of industrial activities. These compounds have an adverse impact on the environment, particularly when generated by industrial processes and then disposed off without adequate treatment. Mycoremediation is defined as the use of fungi for bioremediation, especially degradation or retention of contaminants. Bio

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7

Farhina, Pasha and Uzma Faridi*. "USE OF ENZYME TECHNOLOGY FOR THE DEGRADATION OF HARMFUL XENOBIOTICS (AROMATIC DYE)." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 6693–99. https://doi.org/10.5281/zenodo.2609191.

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<em>The basic objective of the present investigation is to study the enzymatic pre-treatment as alternative physicochemical methods, for enhancing the biodegradability of aromatic dye compounds and was found to be more effective (Alexander et al., 1997). Horseradish peroxidase was extracted and studies for azo degradation at batch scale. The batch studies performed to study the process parameters during azo dye degradation revealed, effect of repeated application of alginate immobilized enzyme on dye degradation as 52%removal of dye in first batch which was reduced to 22.2%in the fifth batch .

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8

Kramer, Constance M., and Martha M. Kory. "Bacteria that degrade p-chlorophenol isolated from a continuous culture system." Canadian Journal of Microbiology 38, no. 1 (1992): 34–37. http://dx.doi.org/10.1139/m92-005.

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Two Gram-positive coryneform bacteria that degraded p-chlorophenol isolated from a continuous culture system are characterized. Isolate B (probably an Arthrobacter sp.) completely removed the p-chlorophenol from a medium with a concomitant increase in cell density within 16 h. Isolate F similarly removed the p-chlorophenol within 28 h but without an increase in cell density. Isolates B and F also removed the p-chlorophenol from a medium with p-chlorophenol as the sole carbon source within 32 and 48 h, respectively. The optimal temperature for p-chlorophenol degradation by both organisms was 25

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9

Preston, Caroline M. "Carbon-13 solid-state NMR of soil organic matter - using the technique effectively." Canadian Journal of Soil Science 81, no. 3 (2001): 255–70. http://dx.doi.org/10.4141/s00-074.

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Solid-state 13C CPMAS NMR offers many options for characterizing carbon in soil organic matter (SOM). Its effectiveness, however, is often limited by a poor understanding of the techniques, and lack of hands-on access and training opportunities for students. Of nearly 250 modern NMR systems in Canada, approximately one is genuinely available for SOM studies, and there is poor communication between NMR operators and SOM users. While quantitative reliability can be addressed to some extent by multiple contact-time experiments or single-pulse (Bloch decay) spectra, it is also important to conside

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10

Popovich, Z., M. Rozhko, I. Chubiy, and N. Kukurudz. "Ecology and dental health of the population of Ukraine." SUCHASNA STOMATOLOHIYA 110, no. 1-2 (2022): 42. http://dx.doi.org/10.33295/1992-576x-2022-1-2-42.

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Resume. Many studies have shown that an important factor in the health of the human body is the state of the environment. The aim of this work is to review the literature on the study of the effects of xenobiotics on dental morbidity. The highest rates of prevalence and intensity of periodontal disease were found in regions with high and very high levels of environmental pollution, the lowest – in a region with relatively low total levels of environmental pollution. Children living in environmentally unfavorable areas have a significant number of somatic diseases, which are combined with high

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11

Melin, Anne-Marie, Annie Perromat, and Gérard Deleris. "The in vivo toxicity of carbon tetrachloride and carrageenan on heart microsomes: analysis by Fourier transform infrared spectroscopy." Canadian Journal of Physiology and Pharmacology 79, no. 9 (2001): 799–804. http://dx.doi.org/10.1139/y01-058.

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We investigated the sensitivity of rat heart microsomes to free radical attack using Fourier transform infrared (FT-IR) spectroscopy. This physico-chemical method seemed a valuable technique: quite sensitive to changes in the vibrational spectra. The spectral variations observed between normal and treated rats were in great part due to reactive oxygen species that led to changes in protein conformation involving β-sheets, aggregation of proteins, and modification of protein synthesis. Carrageenan-induced inflammation slightly enhanced the total lipid content; rearrangement of acyl chains and a

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12

Crump, D. "The effects of UV-B radiation and endocrine-disrupting chemicals (EDCs) on the biology of amphibians." Environmental Reviews 9, no. 2 (2001): 61–80. http://dx.doi.org/10.1139/a01-001.

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Statistical meta-analysis of large and diverse data sets has indicated that amphibians have been declining worldwide since the 1960s. Exposure to UV-B radiation (280320 nm) and endocrine-disrupting chemicals (EDCs) have been considered as possible hypotheses to explain the observed declines. Equivocal conclusions have been reached with respect to the effects of UV-B on amphibian populations. Field and laboratory studies employing both ecologically relevant and enhanced UV-B levels have been conducted using a variety of amphibian species and reports differ with respect to the most sensitive de

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13

Lobykina, E. N., and A. A. Lobykina. "Physiological basis of body detoxification and the role of detox diets." Voprosy dietologii 13, no. 4 (2023): 42–54. http://dx.doi.org/10.20953/2224-5448-2023-4-42-54.

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The idea of alternative medicine which aims to rid the body of toxins, i.e. “alternative detox”, is not new, extremely popular, and diverse. This article presents the result of a systematic review of 100 scientific literary sources on the use of detox diets in population health improvement. Literature review has shown that traditional natural detoxification, which the body copes with on its own, creates preconditions for the development of a new direction of therapy, a personalized detox diet. This is due to the current dramatic increase in exposure of the organism and excretory organs to vari

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14

Khavkin, A. I., and S. I. Sitkin. "The effect of targeted probiotics on the microbiota–gut–immune system axis." Voprosy praktičeskoj pediatrii 18, no. 6 (2023): 107–18. http://dx.doi.org/10.20953/1817-7646-2023-6-107-118.

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The gastrointestinal tract is a multifunctional system that performs numerous functions, including immunity. It is the basis of the body's safety, including neutralizing foreign antigens and xenobiotics, tolerance formation, or elimination. One of the most important protections for humans is the intestinal microbiota. Without symbiosis with trillions of microorganisms inhabiting the human intestine, the vital activity of the macroorganism is impossible. Therefore, the totality of the human and microbiota is considered as a superorganism. Within the framework of this paradigm, the review examin

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15

Rashkivska, IO, NM Nedopytanska, PG Zhminko, NО Kornuta, and YaV Kolyanchuk. "Testing methods for the assessment of chemical neurotoxic effects on the developing organisms in pre- and postnatal period." One Health and Nutrition Problems of Ukraine 54, no. 1 (2021): 41–51. http://dx.doi.org/10.33273/2663-9726-2021-54-1-41-51.

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Aim of the research. Analysis of approaches to the assessment of neurotoxic effects of chemicals during ontogenesis. The dangerous tendency of the increase in the incidence of pathology of the nervous system in the child and the mother, who during pregnancy was exposed to neurotoxicants, necessitates the protection of the child’s body from such a negative effect of chemicals. One of the possible preventive ways to solve this problem is screening of xenobiotics before their widespread application, as well as identification of their ability to cause neurotoxic effects on the body during its deve

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16

Semianiv, I.O., and Yu.R. Sukholytkyi. "Analysis of deletion polymorphism of xenobiotics detoxication system genes in patients with tuberculosis and diabetes mellitus." Journal of Education, Health and Sport 12, no. 7 (2022): 24–79. https://doi.org/10.12775/JEHS.2022.12.07.003.

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<strong>Semianiv I.O., Sukholytkyi Yu.R.</strong> <strong>Analysis of deletion polymorphism of xenobiotics detoxication system genes in patients with tuberculosis and diabetes mellitus</strong><strong>.</strong> <strong>Journal of Education, Health and Sport. 2022;12(</strong><strong>7</strong><strong>):</strong><strong>24-29</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2022.12.07.00</strong><strong>3</strong> <strong>https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.07.00</strong><strong>3</strong> <strong>https://zenodo.org/record/6537402

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17

Zhminko, P. G., T. V. Yurchenko, M. G. Prodanchuk, and M. H. Povoznikov. "Modern methods for studying acute toxicity of pollutants for representatives of aquatic and terrestrial ecosystems and introducing them into practice of the research centre of preventive and regulatory toxicology." Ukrainian Journal of Modern Toxicological Aspects 92, no. 1 (2022): 35–53. http://dx.doi.org/10.33273/2663-4570-2022-92-1-35-53.

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The paper provides a brief historical background on the formation and development of ecotoxicology as a science, reflects the main modern methods and principles for studying the acute toxicity of xenobiotics for representatives of aquatic and terrestrial ecosystems recommended by the OECD (Organization for Economic Cooperation and Development). The classification of acute ecotoxicity of chemicals for land and water test systems is given. Further perspective development of the unit, which will be aimed at expanding ecotoxicological research in accordance with international OECD methods and GLP

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18

Ohnishi, Kohta, Kazuhiro Irie, and Akira Murakami. "Modulation of Protein Quality Control Systems as Novel Mechanisms Underlying Functionality of Food Phytochemicals." Functional Foods in Health and Disease 3, no. 10 (2013): 400. http://dx.doi.org/10.31989/ffhd.v3i10.36.

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Background: Phytochemicals are secondary metabolites of plants that are produced for their defense against environmental stresses, such as polyphenols, which are considered to play a major role in protection against ultraviolet (UV) light-induced oxidative damage, as well as anti-fungal and anti-microbial activities. In addition, there is a great body of evidence showing that phytochemicals exhibit a wide array of physiological activities in humans. Accumulated data show that the bioavailability of most, if not all, phytochemicals is quite poor and their substantial biotransformation after ing

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19

Marina, G. Kokaeva Irina I. Ktsoeva Rustem B. Temiraev Alja N. Doeva Boris A. Dzagurov Zalina A. Kubatieva Soslan G. Kozyrev Eduard V. Beslaneyev Arthur L.Kalabekov Inna I. Kornoukhova. "EFFECT OF PECTIN AND ENZYME PREPARATION ON HEMATOLOGICAL VALUES, FOOD AND SANITARY AND HYGIENIC PROPERTIES OF BROILER MEAT." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 09 (2019): 15998–6005. https://doi.org/10.5281/zenodo.3405453.

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<em>When nitrates are reduced to nitrites, these xenobiotics increase the severity of the intoxication of the body of young and adult poultry, which has an extremely negative effect on the productivity, nutritional and sanitary and hygienic characteristics of poultry products. The goal of the research is to study the effect of citrus pectin and enzyme supplementation in feeds based on barley grain, soy and corn as denitrifying drugs on hematological parameters, meat productivity, nutritional and sanitary-hygienic properties of broiler chicken meat. The objects of the research were broiler chic

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20

Chmil, V. D., O. V. Golokhova, D. Yu Vydrin, and V. I. Kruk. "Relevance of the problem of dioxins and polychlorinated biphenyls (PCBs) determination in baby food products." One Health and Nutrition Problems of Ukraine 52, no. 1 (2020): 32–39. http://dx.doi.org/10.33273/2663-9726-2020-52-1-32-39.

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The Aim of the Article. Analysis of the current state of the problem of the dioxins and polychlorinated biphenyls (PCBs) determination in baby food products and the development of sample preparation methods for determining these xenobiotics in food products for infants and young children. Dioxins form a group of structurally and chemically related chlorinated tricyclic oxygen-containing aromatic compounds (congeners), which includes 75 polychlorinated dibenzo-para-dioxins (PCDDs) and 135 polychlorinated dibenzofurans (PCDFs). The most toxic congeners of dioxins, in which chlorine atoms along w

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21

Poludenko, H. A., P. B. Antonenko, Y. V. Rozhkovskyi, K. О. Antonenko, and K. G. Lobashova. "THE EFFECTIVENESS OF TREATMENT OF PULMONARY TUBERCULOSIS DEPENDING ON CYP3A4 GENOTYPE." Ukrainian Pulmonology Journal 30, no. 1 (2022): 62–66. http://dx.doi.org/10.31215/2306-4927-2022-30-1-62-66.

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Among the factors that can influence the course and effectiveness of the treatment of pulmonary tuberculosis (TB) the genetic characteristics of patients play an important role. It is established that cytochrome (CYP) 3A4/5 is involved in metabolism of more than 30 % of xenobiotics. Consequently, the activity of this enzyme is greatly influenced by responsible genes, such as CYP3А4. The aim of the study was the investigation of prognostic value of CYP3A4 polymorphism on the course and effectiveness of anti-tuberculosis therapy in patients with pulmonary TB. Materials and methods. Using PCR met

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22

Vasetska, OP. "Morphofunctional changes in cells of Tetrahymena pyriformis W infusoria under the influence of plant growth regulators — derivatives of pyridine-n-oxide." Ukrainian Journal of Modern Toxicological Aspects 90, no. 1 (2021): 40–50. http://dx.doi.org/10.33273/2663-4570-2021-90-1-40-50.

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The aim of the Research. To identify morphological changes in Tetrahymena pyriformis W infusoria under the acute exposure to plant growth regulators (PGR) — derivatives of pyridine-N-oxide and compare them to functional disorders of cells. Materials and Methods. In the research we used the 2-methylpyridine-N-oxide, 2,6-dimethylpyridine-N-oxide and their complexes with organic acids (succinic, maleic) or metal salts (ZnCl2, ZnI 2, CoCl2, MnCl2) (a total of 15 substances), synthesized at the Institute of Bioorganic chemistry and Petrochemistry, NAS, Ukraine. Studies were performed on Tetrahymena

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23

Chaika, A. V., та O. V. Fedotov. "ІНТЕНСИВНІСТЬ ПРОЦЕСІВ ПЕРЕКИСНОГО ОКИСНЕННЯ ЛІПІДІВ КСИЛОТРОФНИХ БАЗИДІОМІЦЕТІВ У ГЛИБИННІЙ КУЛЬТУРІ". Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University 3, № 02 (2013): 220. http://dx.doi.org/10.15421/20133_30.

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<p>The aim of the study was to determine the lipid peroxidation (LP) intensity of xylotrophic basidiomycetes cultures under submerged fermentation on glucose-peptone medium. The materials were submerged mycelium and culture filtrate of 79 strains of 18 species xylotrophic basidiomycetes. Among the studied strains, 60 strains belong to the order <em>Agaricales</em> and 19 – to order <em>Polyporales</em>. Most of the strains (85%) were isolated from the fruiting bodies collected in different localities of Donetsk city and its region. The following methods were used.

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24

Vasetska, O. P. "Toxicodynamics of Chlorpyrifos and “Ivin” Combined Action under Prolonged Admission." Ukrainian Journal of Modern Toxicological Aspects 89, no. 2 (2020): 5–13. http://dx.doi.org/10.33273/2663-4570-2020-89-2-5-13.

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The combined action of pesticides is one of the problems of toxicology, because in comparison to individual active substances, their mixtures can increase toxicity and delayed action effects, which is a risk to human health. It is known that plant growth regulators (PGR) when applied together with pesticides help to reduce the quantitative rates of pesticides applied, the accumulation of pesticides and heavy metals in plants, reduce the acute toxicity of xenobiotics. The combined effect of the prolonged admission of PGRs and pesticides is an unexplored area, and it is an important issue in pre

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25

Kurdil, N. V., and V. V. Andriuschenko. "Practical aspects of using extracorporal detoxification methods in the treatment of acute chemical poisoning." One Health and Nutrition Problems of Ukraine 57, no. 2 (2023): 98–109. http://dx.doi.org/10.33273/2663-9726-2022-57-2-98-109.

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Abstract. The structure of xenobiotics that cause poisoning and the need for hospitalization is constantly changing. Today, psychotropic and narcotic substances and their precursors have become the main cause of severe poisonings that require emergency medical care. At the same time, another problem is the combined use of narcotic substances and alcohol, which often causes multiorgan dysfunction and prompts doctors to search for new treatment approaches, using traditional methods of afferent and efferent therapy in combination with modern extracorporeal detoxification technologies. Aim. Study

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26

Qader, Abdul, Zahira Batool, and Hamza Tariq. "Induction of Thyroid Hormones Disruption by Exposure of Dioxins and Phthalates: A Comprehensive Review." Journal of Medical Research 9, no. 3 (2023): 72–75. http://dx.doi.org/10.31254/jmr.2023.9308.

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The main objective of this study is to elaborate the crucial effect of dioxins and phthalates on thyroid hormones such as tetraiodothyronine (T4) and tri-iodothyronine (T3) in body fluids. The literature evidences have been collected from Google Scholar, PubMed and Medline by using different key words. All literature evidences showed a drastic effect of dioxins and phthalates on the status of thyroid hormones. Hexachlorobenzene (HCB) is an environmental pollutant that increases activity of malic enzyme (ME) by increasing ME gene transcription. ME interact with aryl hydrocarbon receptors (AhR)

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27

Novoselova, O. G., D. P. Polyakov, E. I. Kondratyeva, et al. "Risk factors for chronic rhinosinusitis with nasal polyps in children with cystic fibrosis." Voprosy praktičeskoj pediatrii 17, no. 3 (2022): 55–64. http://dx.doi.org/10.20953/1817-7646-2022-3-55-64.

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The investigation of the pathogenesis of chronic rhinosinusitis in patients with cystic fibrosis (CF) and analysis of molecular biomarkers can promote the development of tailored approaches to its treatment and prevention. Objective. To analyze associations between sinonasal polyposis and genetic polymorphisms of the xenobiotic metabolizing enzymes (XMEs) in CF patients. Patients and methods. We performed a retrospective comparative analysis of 145 CF patients from the Russian Federation (RF) and 82 patients from the Republic of Belarus (RB). Patients provided blood samples that were later use

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28

Aftabul Alam, S. K., and P. Saha. "Decolorization of p-nitrophenol and draft genome sequence of Pseudomonas sp. strain PNPG3: A preliminary report." Journal of Environmental Biology 44, no. 4 (2023): 578–86. http://dx.doi.org/10.22438/jeb/44/4/mrn-5061.

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Aim: To study decolorization (with concomitant depletion) of p-nitrophenol by a bacterial strain designated as PNPG3 and determination of draft genome sequence of the strain to understand its potential. Methodology: A comparative study of PNP’s decolorization (with concomitant removal) in three different test conditions was undertaken. The experiment was carried out in one-liter volume Schott Duran bottles. Genomic DNA was extracted and draft genome sequence was determined using Illumina HiSeqX platform. Raw reads were assembled and subjected to subsystem classification using several bioinform

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29

Knaebel, David B., and J. Robie Vestal. "Effects of intact rhizosphere microbial communities on the mineralization of surfactants in surface soils." Canadian Journal of Microbiology 38, no. 7 (1992): 643–53. http://dx.doi.org/10.1139/m92-105.

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This work addressed the impact that the rhizosphere has on the biodegradation of foreign organic compounds. This was examined with live plants grown in a sewage sludge amended agricultural soil and a woodlot soil. Microcosms were designed that contained soil, roots, and microbial biomass in a compartment that excluded most of the plant stem and all of the leaf biomass. Control microcosms contained soils without plants and had no plant-induced rhizosphere microbial communities. Microbial mineralization of 14C-labelled organic compounds (anionic, cationic, and nonionic surfactants) was measured

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Chala, О., О. Chaly, and S. Nagorny. "The mathematical model for forecasting the accumulation of heavy metals in pig production." Tehnologìâ virobnictva ì pererobki produktìv tvarinnictva, no. 2(158) (November 24, 2020): 120–27. http://dx.doi.org/10.33245/2310-9289-2020-158-2-120-127.

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The results of research represent the impact of extensive doses of heavy metals such as lead and cadmium in store pigs bodies. Heavy metals were fed jointly and individually in the doses exceeding the maximum allowable concentrations in the fodder by 10 and 20 times. Therefore, the process of intoxication of the biological object (a swine) by heavy metals is modeled in a way similar to that, which might occur as the result of environmental pollution. The study was performed in order to determine the targets and the extent of the impact of heavy metals exerted upon the body weight, weight of in

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31

Malov, S. I., L. S. Orlova, L. A. Stepanenko, O. B. Ogarkov, I. V. Malov, and N. D. Yushchuk. "Evaluation of predictors of liver fibrosis progression in patients with hepatitis C after successful virus elimination." Infekcionnye bolezni 20, no. 1 (2022): 64–73. http://dx.doi.org/10.20953/1729-9225-2022-1-64-73.

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Objective. To determine environmental and genetic factors associated with fibrosis progression after virus elimination as a result of direct-acting antiviral therapy by follow-up dispensary observation of patients with chronic hepatitis C with moderate and severe liver fibrosis (F2–F3 according to the METAVIR scoring system). Patients and methods. This study included 301 patients (166 men and 135 women) aged 20-64 years with chronic hepatitis C virus (HCV). A sustained virologic response was achieved in all patients after therapy with direct-acting antiviral agents. Patients were followed up f

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32

Kolpakov, I. Ye, V. Yu Vdovenko, V. M. Zyhalo, et al. "THE ROLE OF HEREDITARY PREDISPOSITION (POLYMORPHIC MARKERS OF GLUTATHIONE-S-TRANSFERASE, CATALASE, ENDOTHELIAL NITROGEN OXIDE SYNTHASE GENES) AND SOME ADVERSE ENVIRONMENTAL FACTORS IN THE DEVELOPMENT OF BRONCHO-OBSTRUCTIVE PATHOLOGY IN CHILDREN LIVING IN RADIOACTIVELY CONTAMINATED AREAS." Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology 28 (2023): 329–47. http://dx.doi.org/10.33145/2304-8336-2023-28-329-347.

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Objective: summarizing the results of many years of research by the authors on the influence of gene polymorphisms encoding xenobiotic biotransformation enzymes (GSTТ1, GSTM1, GSTР1), antioxidant protection (С-262Т of the catalase gene), endothelial nitric oxide synthase (4a/4b VNTR polymorphism of the eNOS gene), and some environmental factors on the occurrence of broncho-obstructive disorders and the development of bronchial asthma in children, residents of radioactively contaminated areas. Materials and methods. The examined school-aged children were residents of radioactively RCA who had n

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33

Vasileva, Evgenia, Tsvetomila Parvanova-Mancheva, and Venko Beschkov. "CLASSICAL AND NEW ASPECTS IN DEGRADATION OF AROMATIC XENOBIOTICS." Ecological Engineering and Environment Protection, March 20, 2019, 37–53. http://dx.doi.org/10.32006/eeep.2019.1.3753.

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Organic chemical mixtures are prevalent in waste waters from industrial and municipal sources as well as in contaminated groundwater. Phenols are pollutants found in wastewaters from oil refineries, chemical plants, explosives, resins and coke manufacture, coal conversion, pesticide and textile industries. The main contaminants of refinery wastewater include phenols, polycyclic aromatic hydrocarbons (PAHs) as well as heavy metals. Among these toxic pollutants, phenols are considered to be the most hazardous ones, and they are certainly the most difficult to remove. Phenolic compounds are toxic

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Tatarina, O. V., B. A. Nasibullin, and V. L. Vasiuk. "STRUCTURAL AND FUNCTIONAL CHANGES IN THE DETOXIFICATION AND EXCRETORY SYSTEM OF THE RAT ORGANISM DURING GENTAMICIN INTOXICATION." December 27, 2019. https://doi.org/10.5281/zenodo.3594877.

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Tatarina O. V., Nasibullin B. A., Vasiuk V. L. STRUCTURAL AND FUNCTIONAL CHANGES IN THE DETOXIFICATION AND EXCRETORY SYSTEM OF THE RAT ORGANISM DURING GENTAMICIN INTOXICATION. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2019;4(58):150-156. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.3594877 http://aptm.org.ua          STRUCTURAL AND FUNCTIONAL CHANGES IN THE DETOXIFICATION AND EXCRETORY SYSTEM OF THE RAT ORGANISM DURING GENTAMICIN INTOXICATION   Tatarina1 O. V., Nasibullin2 B. A., Vasiuk3 V. L.   1

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Bagmut, I. Yu., N. V. Zharova, T. M. Popova, V. I. Zhukov та S. O. Stetsenko. "Express experimental evalution of mutagenic activity of complex phoshorus-containing organic mixtures = Експрес-експериментальна оцінка мутагенної активності складних фосфоровмісних органічних сумішей = Экспресс-экспериментальная оценка мутагенной активности сложных фосфоросодержащих органических смесей". 30 жовтня 2016. https://doi.org/10.5281/zenodo.164190.

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Bagmut I. Yu., Zharova N. V., Popova T. M., Zhukov V. I., Stetsenko S. O. Express experimental evalution of mutagenic activity of complex phoshorus-containing organic mixtures = Експрес-експериментальна оцінка мутагенної активності складних фосфоровмісних органічних сумішей =Экспресс-экспериментальная оценка мутагенной активности сложных фосфоросодержащих органических смесей Journal of Education, Health and Sport. 2016;6(10):443-454. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.164190 http://ojs.ukw.edu.pl/index.php/johs/article/view/3971 The journal has had 7 points in Ministry of Sc

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36

Pasiieshvili, T. M. "АКТИВНІСТЬ КАСПАЗИ-1 ТА ФЕРМЕНТІВ ГЛУТАТІОНОВОЇ ЛАНКИ АНТИОКСИДАНТНОЇ СИСТЕМИ У ОСІБ МОЛОДОГО ВІКУ З КОМОРБІДНІСТЮ ГАСТРОЕЗОФАГЕАЛЬНОЇ РЕФЛЮКСНОЇ ХВОРОБИ ТА АВТОІМУННОГО ТИРЕОЇДИТУ = THE ACTIVITY OF CASPASE-1 AND ENZYMES OF THE GLUTATHIONE LINK OF THE ANTIOXIDANT SYSTEM IN YOUNG PERSONSE WITH COMORBIDITY OF GASTROESOPHAGEAL REFLUX DISEASE AND AUTOIMMUNE THYROIDITIS". 28 вересня 2020. https://doi.org/10.5281/zenodo.4118645.

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Pasiieshvili T. M. THE ACTIVITY OF CASPASE-1 AND ENZYMES OF THE GLUTATHIONE LINK OF THE ANTIOXIDANT SYSTEM IN YOUNG PERSONSE WITH COMORBIDITY OF GASTROESOPHAGEAL REFLUX DISEASE AND AUTOIMMUNE THYROIDITIS. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2020;3(88):30-35. ISSN 0049-6804. DOI http://dx.doi.org/10.5281/zenodo.4118645 http://www.herald.com.ua     УДК 616.329/.333-008.17:616.441-002]-053.67-092:612.015.11 DOI http://dx.doi.org/10.5281/zenodo.4118645     АКТИВНІСТЬ КАСПАЗИ-1 ТА ФЕРМЕНТІВ ГЛУТАТІОНОВОЇ ЛАНКИ АНТИОКСИДАНТНОЇ СИСТЕМИ У ОСІБ МОЛОДОГО ВІКУ З КОМОРБІДНІСТЮ ГАСТРОЕЗОФАГЕАЛЬНО

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Bessone, Fernando, and Raúl J. Andrade. "Drug Hepatotoxicity." DeckerMed Gastroenterology, Hepatology and Endoscopy, June 4, 2018. http://dx.doi.org/10.2310/gastro.14006.

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Idiosyncratic drug-induced liver injury (DILI) caused by xenobiotics (drugs, herbals, and dietary supplements) is an elusive liver disease presenting with a range of phenotypes and severity, including acute hepatitis that is indistinguishable from viral hepatitis, autoimmune hepatitis, steatosis, fibrosis or rare chronic vascular syndromes, asymptomatic liver test abnormalities,and acute liver failure. Case definition and characterization using liver biochemistry and histology are crucial for appropriate phenotyping. The incidence of DILI is probably higher than expected by the cases that are

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38

Bessone, Fernando, and Raúl J. Andrade. "Drug Hepatotoxicity." DeckerMed Medicine, June 4, 2018. http://dx.doi.org/10.2310/im.14006.

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Idiosyncratic drug-induced liver injury (DILI) caused by xenobiotics (drugs, herbals, and dietary supplements) is an elusive liver disease presenting with a range of phenotypes and severity, including acute hepatitis that is indistinguishable from viral hepatitis, autoimmune hepatitis, steatosis, fibrosis or rare chronic vascular syndromes, asymptomatic liver test abnormalities,and acute liver failure. Case definition and characterization using liver biochemistry and histology are crucial for appropriate phenotyping. The incidence of DILI is probably higher than expected by the cases that are

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39

Golovkova, T. A. "Ecotoxicological aspects of the influence of cadmium on the human organism." March 30, 2018. https://doi.org/10.5281/zenodo.1239459.

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Golovkova T. A. Ecotoxicological aspects of the influence of cadmium on the human organism. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2018;1(51):146-149. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.1239459 http://aptm.org.ua     UDК: 612.66-055.2:546.48   ECOTOXICOLOGICAL ASPECTS OF THE INFLUENCE OF CADMIUM ON THE HUMAN ORGANISM   Golovkova T. A.   State establishment "Dnipropetrovsk Medical Academy of Health Ministry of Ukraine" Department of General Hygiene, Dnipro, Ukraine   Summary Technogenic pressure

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Golovkova, T. A., E. M. Biletska, N. М. Onul, and O. V. Antonova. "ASSESSMENT OF THE ADVERSE ENVIRONMENTAL FACTORS INFLUENCE ON THE ORGANISM OF PREGNANT WOMEN." May 24, 2019. https://doi.org/10.5281/zenodo.3250560.

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Golovkova T. A., Biletska E. M., Onul N. М., Antonova O. V. ASSESSMENT OF the ADVERSE ENVIRONMENTAL FACTORS influence ON THE ORGANISM OF PREGNANT WOMEN. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2019;2(56):32-39. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.3250560 http://aptm.org.ua     UDC 614.7: 613: 612.63   ASSESSMENT OF the ADVERSE ENVIRONMENTAL FACTORS influence ON THE ORGANISM OF PREGNANT WOMEN   T. A. Golovkova, E. M. Biletska, N. М. Onul, O. V. Antonova   Department of General Hygiene of State Institution &laquo

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Golovkova, T. A. "Ecologic constituent of risk of reproductive complications." May 31, 2018. https://doi.org/10.5281/zenodo.1291566.

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Golovkova T. A. Ecologic constituent of risk of reproductive complications. Journal of Education, Health and Sport. 2018;8(5):284-289. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1291566 http://ojs.ukw.edu.pl/index.php/johs/article/view/5583         The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki Universi

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Broshkov, M. M., and V. B. Kusturov. "Toxoplasmosis as a factor in chronic diseases in dogs." April 29, 2022. https://doi.org/10.12775/JEHS.2022.12.04.021.

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Broshkov M. M., Kusturov V. B. Toxoplasmosis as a factor in chronic diseases in dogs. Journal of Education, Health and Sport. 2022;12(4):271-292. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.04.021 https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.04.021 https://zenodo.org/record/7068537         The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplin

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Janeczko, Dominika, Anna Orzeł, Barbara Klatka, Magdalena Hołowczuk, Michał Terpiłowski, and Michał Tchórz. "Patient with depression poisoned with psychopharmaceutics and ethanol – case report." July 5, 2019. https://doi.org/10.5281/zenodo.3269684.

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<strong>Janeczko</strong><strong> </strong><strong>Dominika, Orzeł Anna, Klatka Barbara, Hołowczuk Magdalena, Terpiłowski Michał, Tchórz Michał</strong><strong>. </strong><strong>Patient with depression poisoned with psychopharmaceutics and ethanol – case report</strong><strong>.</strong><strong> </strong><strong>Journal of Education, Health and Sport. 2019;9(7):228-23</strong><strong>2</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3269684</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/article/view/712</strong><strong>3</strong> <s

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44

Vlasova, Olena Vasylivna, Mariana Ivanivna Hrytsiuk, and Uliana Ivanivna Marusyk. "Influence of ultra-small particles (10-20 nm) in the atmospheric air of Chernivtsi during intrauterine development on the course of sepsis in newborns." November 29, 2019. https://doi.org/10.5281/zenodo.3684459.

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Vlasova Olena Vasylivna, Hrytsiuk Mariana Ivanivna, Marusyk Uliana Ivanivna. Influence of ultra-small particles (10-20 nm) in the atmospheric air of Chernivtsi during intrauterine development on the course of sepsis in newborns. Journal of Education, Health and Sport. 2019;9(11): 374-380. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2019.09.11.034 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2019.09.11.034 http://dx.doi.org/10.5281/zenodo.3684459         The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation

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45

Nguyễn, Trọng Nghĩa. "Sự thiếu vitamin D ảnh hưởng sức khỏe và một số bệnh tật". Vietnam Journal of Diabetes and Endocrinology, 30 квітня 2019. http://dx.doi.org/10.47122/vjde.33(2).1.

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Vitamin D deficiency are increasing at a global level, and they are associated with increased risk of various diseases. In Vietnam, the prevalence of Vitamin D deficiency ranged from 20% to 46%, up to 81.6% in the population in South Asia, 69.5% in the US and 86.4% in European countries. Vitamin D is one of the essential nutrients to sustain the human health. As a member of the steroid hormone family, it has a classic role in regulating metabolism of calcium and a non-classic role in affecting cell proliferation and differentiation. With the finding of the vitamin D receptor in nearly every ti

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46

Idress, Hamad Attitalla and Marei Ahmed Altayar. "ROLE OF BACTERIA AND THEIR EFFECT ON (JUNIPERUS PHOENICEA) AS AMODEL MEDICIAL PLANTS IN AL-JABAL AL- AKHDAR REGIN." April 1, 2021. https://doi.org/10.5281/zenodo.4658036.

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<em>Since photosynthesis is the primary process through which light energy absorbed and converted into organic matter, thus, plant chlorophyll pigment (forms A and B) plays an essential role in the progression absorbed solar energy and synthesis of organic matter in a plant. Therefore, this paper aims at the extent to which the optical activity of chlorophyll molecules monitored and methods (non-destructive and destructive) for quantification of chlorophyll content in plants. These methods using to estimate the effect of different stress factors (abiotic, biotic, and xenobiotic) on the efficie

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47

Rykalo, N. A., та O. V. Baylo. "Pathogenetic analysis of biochemical markers of cytolysis and cholestas syndrome at chronic liver damage by chlorpromazine = Патогенетичний аналіз біохімічних маркерів синдрому цитолізу та холестазу при хронічному ураженні печінки хлорпромазином у щурів, залежно від дози та тривалості введення". 30 червня 2022. https://doi.org/10.5281/zenodo.6814972.

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Rykalo N. A., Baylo O. V. Pathogenetic analysis of biochemical markers of cytolysis and cholestas syndrome at chronic liver damage by chlorpromazine = Патогенетичний аналіз біохімічних маркерів синдрому цитолізу та холестазу при хронічному ураженні печінки хлорпромазином у щурів, залежно від дози та тривалості введення \\ Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2022;2(68):106-113. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.6814972 http://aptm.org.ua     УДК 615 (075.8) DOI: https://zenodo.org/record/6814972   PATHOGENETIC ANALY

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Коloskova, О. К., Т. М. Bilous, L. A. Ivanova, M. V. Dikal, and T. G. Kopchuk. "Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism." January 31, 2018. https://doi.org/10.5281/zenodo.1185397.

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Коloskova О. К., Bilous Т. М., Ivanova L. A., Dikal M. V., Kopchuk T. G. Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism. Journal of Education, Health and Sport. 2018;8(1):198-205. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.11853917 http://ojs.ukw.edu.pl/index.php/johs/article/view/5315 https://pbn.nauka.gov.pl/sedno-webapp/works/858114       The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN

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Nikolaeva, A. V., та S. A. Shnayder. "Разработка модели экспериментального пародонтита = Development of the model of experimental periodontitis". 17 грудня 2015. https://doi.org/10.5281/zenodo.35463.

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<strong>Nikolaeva A. V., Shnayder S. A. </strong><strong>Разработка</strong> <strong>модели</strong> <strong>экспериментального</strong> <strong>пародонтита</strong><strong> = Development of the model of experimental periodontitis. </strong><strong>Journal of Education, Health and Sport</strong><strong>. </strong><strong>2015;5(12):317-325</strong><strong>. </strong><strong>ISSN 2391-8306</strong><strong>. DOI</strong> <strong>http://dx.doi.org/10.5281/zenodo.35463</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A317-325</strong> <strong>http://pbn.nauka.go

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Vasil’ev, A. A., A. I. Gozhenko, V. M. Sirman та B. A. Nasibullin. "Изменения показателей общесоматического состояния при патологии органов брюшной полости и возможность их коррекции промыванием брюшной полости физиологическим раствором обогащенным ксеноном = Changes in state somatic abdominal pathology and possibility of their correction by washing the abdominal cavity with saline enriched xenon". 30 вересня 2015. https://doi.org/10.5281/zenodo.35720.

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<strong>Vasil</strong><strong>’</strong><strong>ev A</strong><strong>. </strong><strong>A</strong><strong>., </strong><strong>Gozhenko A</strong><strong>. </strong><strong>I</strong><strong>., </strong><strong>Sirman V</strong><strong>. </strong><strong>M</strong><strong>., </strong><strong>Nasibullin B</strong><strong>. </strong><strong>A</strong><strong>. </strong><strong>Изменения</strong> <strong>показателей</strong> <strong>общесоматического</strong> <strong>состояния</strong> <strong>при</strong> <strong>патологии</strong> <strong>органов</strong> <strong>брюшной</strong> <strong>п

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