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Дисертації з теми "Leptin receptors"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 31 січня 2023

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1

Yang, Seung Hak. "Gene expression of leptin and leptin receptors in beef cattle." Kyoto University, 2007. http://hdl.handle.net/2433/136511.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第13091号<br>農博第1596号<br>新制||農||938(附属図書館)<br>学位論文||H19||N4217(農学部図書室)<br>UT51-2007-H364<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授矢野秀雄, 教授今井裕, 教授久米新一<br>学位規則第4条第1項該当

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2

Duggal, Priya S. "Leptin action on ovulation and leptin receptors across the rat oestrous cycle /." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phd866.pdf.

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3

Chikani, Gentle P. "LEPTIN RECEPTORS IN CAVEOLAE: REGULATION OF LIPOLYSIS IN 3T3-L1 ADIPOCYTES." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_theses/382.

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The present study has tested the hypothesis that leptin receptors are localized in caveolae and that caveolae are involved in the leptin-induced stimulation of lipolysis in 3T3-L1 adipocytes. Leptin, a peptide hormone, is secreted primarily by adipocytes and has been postulated to regulate food intake and energy expenditure via hypothalamic-mediated effects. Exposure to leptin increases the lipolytic activity in 3T3-L1 adipocytes. We isolated caveolae from 3T3-L1 adipocytes using a detergent free sucrose gradient centrifugation method. Leptin receptors were localized in the same gradient fract

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4

De, Silva Andrea, and mikewood@deakin edu au. "The role of leptin receptors in the development of obesity." Deakin University. School of Health Sciences, 1999. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051125.111246.

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The focus of this dissertation was leptin and the leptin receptor, and the role of these genes (OB and OB-R) in the development of obesity and type 2 diabetes in humans and Psammomys obesus, a polygenic rodent model of obesity and type 2 diabetes. Studies in humans showed that circulating leptin concentrations were positively associated with adiposity, and independently associated with circulating insulin and triglyceride concentrations. Analysis of two leptin receptor sequence polymorphisms in a Caucasian Australian population and a population of Nauruan males, with very high prevalence rates

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5

Xu, Jialin, and 徐嘉林. "B lymphocyte development and function in leptin receptor-deficient mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45011096.

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6

Chikani, Gentle. "Leptin receptors in caveolae regulation of lipolysis in 3T3-L1 adipocytes /." Lexington, Ky. : [University of Kentucky Libraries], 2004. http://lib.uky.edu/ETD/ukynusc2004t00203/thesis.pdf.

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Thesis (m.s.)--University of Kentucky, 2004.<br>Title from document title page (viewed Jan. 7, 2005). Document formatted into pages; contains 70 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 58-68).

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7

Mak, Amy, and 麥安美. "Expression and regulation of leptin receptor in human and mouse oviduct." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010869.

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8

Soedling, Helen. "The role of leptin receptors in the endocrine pancreas and nucleus tractus solitarius." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/63933.

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The highly controlled regulation of pancreatic hormone secretion is vital to keep the body’s glucose concentration at a constant level. Defects in the regulation of glucose levels are involved in several metabolic diseases, including type 2 diabetes and obesity. Leptin is a satiety hormone with important roles in the maintenance of body weight and glucose homeostasis. Mice that lack leptin (ob/ob) or the leptin receptor (db/db) are massively obese and have diabetes symptoms. Leptin has been demonstrated to have an effect on glucose homeostasis that is suggested to be secondary to the obesity t

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9

Håkansson, Ovesjö Marie-Louise. "Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4178-5/.

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10

Vaughan, Tamisha Y. "Novel Mechanisms Underlying the Inflammatory Effects of Leptin and Low Dose Endotoxin." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/28013.

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Obesity over the last several has become a major health concern in our country as well as the world. Obesity is also one of the risk factors which lead to several inflammatory complications such as diabetes, artherosclerosis, etc. Two leading factors involved in the causes of inflammatory complications include leptin and low dose endotoxin lipopolysaccharide (LPS). However, the mechanism underlying the involvement of these two mediators is not clearly understood. The purpose of this study is to understand the mechanism underlying inflammatory complications caused by leptin and low dose endo

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11

Fujiwara, Clarissa Tamie Hiwatashi. "Efeito dos polimorfismos nos genes da leptina e do receptor da leptina sobre a compulsão alimentar em crianças e adolescentes obesos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-30102014-104249/.

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INTRODUÇÃO: A obesidade na infância e adolescência representa uma epidemia global e figura como um problema de saúde pública proeminente de prevalência crescente. A obesidade frequentemente está associada à compulsão alimentar periódica (CAP) e componentes genéticos participam de sua etiologia multifatorial. Polimorfismos de nucleotídeo único (SNPs) no gene da leptina (LEP) e do receptor da leptina (LEPR) podem modificar a expressão da leptina e de suas vias de sinalização e, consequentemente, alterar a regulação do apetite e da saciedade, contribuindo assim para a etiopatogenia e manutenção d

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12

Goodrick, Steven James. "Adipose tissue derived cytokine like molecules (leptin, IL 6 and TNF Î±) : their regulation and interaction with reference to their soluble receptors." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249694.

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13

Lundåsen, Thomas. "Studies on the hormonal regulation of bile acid synthesis /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-053-4/.

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14

Pereira, Jorge Luiz Alves. "Análise molecular e morfométrica da próstata ventral de ratos injetados com leptina." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3870.

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Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro<br>O objetivo deste estudo foi avaliar o efeito da administração de leptina no lobo ventral da próstata de ratos adultos. Vinte ratos Wistar machos e adultos foram divididos em 2 grupos: L - animais foram injetados com 50 μL diária de leptina (8 μg / 100 g PC, subcutânea) durante quatro dias e C - animais receberam o mesmo volume de solução salina. Perfil lipídico e níveis séricos de testosterona foram avaliados. O lobo ventral da próstata foi processado para análise histomorfométrica. Expressão dos genes da aromatase, recepto

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15

Silva, Alexandre Galvão da. "Influência dos polimorfismos do receptor de leptina e o impacto da dieta e treinamento físico sobre as variáveis antropométricas, metabólicas e neurovasculares em mulheres obesas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-18022011-155547/.

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A leptina é um componente importante do complexo sistema fisiológico que regula o armazenamento, o equilíbrio e o uso de energia pelo organismo. É descrito na literatura que a concentração plasmática de leptina e/ou a quantidade de mRNA de leptina nos adipócitos, correlacionam-se positivamente com o gênero, a ingesta calórica, o IMC, e a massa de tecido adiposo. A leptina pode aumentar o gasto energético por meio da estimulação nervosa simpática. A ação tecidual da leptina se da através de sua ligação com seu receptor. O receptor de leptina apresenta heterogeneidade na população humana, com na

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16

Osorio, Clarice Fraga Esteves Maciel. "Expressão da leptina e seu receptor no câncer de próstata." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6729.

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O câncer de próstata é o tumor não cutâneo mais comum entre homens e responsável pela segunda maior mortalidade entre os tumores neste sexo. Diferentes métodos são utilizados com o objetivo de determinar o prognóstico do paciente portador de câncer de próstata, contudo existe grande heterogeneidade quando estes são usados individualmente. A leptina é um hormônio peptídico envolvido na regulação da ingestão alimentar, do metabolismo, do gasto energético, além de função neuroendócrina. Este hormônio parece estar envolvido na patogênese de alguns tipos de tumores, inclusive os adenocarcinomas de

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17

Moreira, Fabiana. "Leptina em fêmeas suínas: relação com status reprodutivo e causas de descarte." Universidade Federal de Pelotas, 2011. http://repositorio.ufpel.edu.br/handle/ri/2579.

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Made available in DSpace on 2014-08-20T14:38:04Z (GMT). No. of bitstreams: 1 tese_fabiana_moreira.pdf: 1442913 bytes, checksum: 613ed46b361d675bfb046a7b74462171 (MD5) Previous issue date: 2011-11-22<br>Leptin is a multifunctional peptidic hormone, primarily produced by the adipose tissue, which has receptors (Ob-Rs) in reproductive organs, hypothalamus and hypophysis, acting in the appetite regulation and energetic expenditure, potentially influencing the expression of the reproductive function, at puberty and lactation. Reproductive failure are the main causes for female culling, repr

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18

Kalyani, Manu. "Interaction between Prolactin and the Hypothalamic-Pituitary-Adrenal (HPA) axis." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1397233916.

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19

Quinton, Naomi Deborah. "Leptin and the leptin receptor : molecular and genetic studies." Thesis, Sheffield Hallam University, 2000. http://shura.shu.ac.uk/20663/.

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Leptin, a 16kDa protein, is secreted primarily by adipose tissue. Its effects are pleiotropic, with known roles in body mass regulation, haematopoiesis, immune function and reproduction. Studies of the leptin system in females were undertaken to complement existing animal and human studies. Serum leptin levels were found to increase in the luteal phase of the menstrual cycle raising the possibility of a role for leptin at the time of implantation. RT-PCR studies showed that leptin receptors were expressed in the human endometrium throughout the menstrual cycle. In these preliminary studies, th

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20

Aloulou, Nijez. "Rôle de la leptine dans le cancer colorectal humain." Thesis, Paris Est, 2008. http://www.theses.fr/2008PEST0027.

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Par sa fréquence et sa gravité, le CCR représente un réel problème de santé publique. Avec 37000 nouveaux cas par an et 15% des décès, il constitue la 2ème cause de mortalité par cancer en France. Malgré d'importants progrès thérapeutiques durant cette dernière décennie, il rest un cancer de mauvais pronostic. Des facteurs génétiques et environnementaux ont été impliqués dans la genèse de ce cancer. La caractérisation moléculaire du CCR a permis d'identifier les tumeurs par instabiblité génique, appelées MSI (Microsatelite Instability) possédant des anomalies de réparation d'appariement d'ADN

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21

Fazeli, Mehdi. "Development and assessment of a leptin receptor antagonist." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425597.

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22

Äijälä, M. (Meiju). "Studies about contribution of leptin receptor in cardiovascular risk." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526203058.

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Abstract Leptin is a hormone secreted by adipose tissue. It is involved in the regulation of appetite and energy expenditure. Leptin binds to its receptor (LEPR) that is expressed in the central nervous system as well as in other tissues including adipocytes and endothelial cells. Plasma leptin level reflects the amount of adipose tissue and previously, it has been shown to be associated with the risk for coronary artery disease. Two LEPR polymorphisms, Lys109Arg and Gln223Arg, have been extensively studied and they have been associated with several risk factors of atherosclerosis. Earlier stu

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23

Xu, Jialin. "B lymphocyte development and function in leptin receptor-deficient mice /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35507895.

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24

Dupuis, Lisa. "Molecular mechanisms of leptin receptor signaling in ovarian granulosa cells." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114600.

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Extreme deviations from what is considered normal body weight, from anorexia to obesity, have been linked to reduced reproductive function in females. Discovered in 1994, leptin is a signaling hormone released from adipose tissue to mediate satiety effects in the hypothalamus. Leptin secretion is directly proportional to amount of body fat and evidence has accumulated that leptin and its receptor (Lepr) are found in a variety of tissues including granulosa cells (GCs) of the ovary. Thus, leptin through its receptor may play a role in reproductive function in females. Many studies have examined

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25

Mistrik, Pavel. "Molecular studies on the interaction of leptin with its receptor." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341988.

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26

Marchiori, Millie de Oliveira. "Imunomarcação de leptina no endométrio de éguas e sua relação com estresse, obesidade e ciclo estral." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/181389.

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A leptina é um hormônio peptídico multifuncional, produzido principalmente pelo tecido adiposo, possuindo receptores (Ob-Rs) nos órgãos reprodutivos, hipotálamo e hipófise. Os glicocorticóides, como o cortisol, também influenciam diretamente a produção de leptina. A importância desses dois hormônios na atividade reprodutiva tem sido descrita por diversos autores, que observaramo envolvimento de ambos, na melhoria dos índices reprodutivos, seja por sua influência direta no eixo hipotalâmico-hipofisário-gonadal, na maturação dos oócitos ou na preparação uterina para receber o concepto. No entant

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27

Mak, Amy. "Expression and regulation of leptin receptor in human and mouse oviduct /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36434036.

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28

Wade, Jennifer M. "Synergistic effects of the serotonin 2C receptor and leptin on glucose homeostasis." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261271.

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29

Marin, Débora. "Associação dos polimorfismos G2548A e GLN223ARG com parâmetros antropométricos em mulheres saudáveis." reponame:Repositório Institucional da UNIVATES, 2014. http://hdl.handle.net/10737/719.

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30

Herrick, Jeffrey. "The effects of obesity and surgically-induced weight loss on exercise ventilation: influence of central adiposity and serum leptin." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/6.

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Truncal adiposity impairs ventilation in obese adults by altering normal ventilatory mechanics. Leptin, an inflammatory adipocytokine, is elevated in obesity and has been shown to alter ventilatory responses to exercise. Leptin’s bioavailability appears to be regulated by its soluble receptor (LRe), which is reduced in obesity. Roux-en-Y gastric bypass surgery (RYGBS) is a weight loss intervention that reduces total fat mass and improves several obesity related co-morbidities including pulmonary dysfunction. The purpose of this study was to first evaluate the differences between ventilatory

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31

Oliveira, Raquel de. "Estudo de variantes da leptina do receptor de leptina: impacto sobre as características relacionadas com a obesidade." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-22092017-163240/.

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Neste estudo, foi avaliada a relação entre polimorfismos dos genes da leptina (LEP) e receptores da leptina (LEPR) e parâmetros antropométricos, leptinemia glicemia e lipídeos séricos, em indivíduos da população brasileira. Foram incluídos 238 indivíduos com idade entre 30 e 80 anos. Foram medidos o índice de massa corporal (IMC), a cintura abdominal (CA) e a razão cintura quadril (RCQ). Amostras de sangue periférico foram obtidas para análise do perfil bioquímico e extração de DNA. Os polimorfismos de nuleotideo único (SNPs) LEP G-2548A e LEPR Lys109Arg, Gln223Arg e Lys656Asn foram detectados

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32

Narayanan, Eswar. "Non-repetitive Structures In Proteins : Effects Of Side-chain And Solvent Interactions With The Backbone." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/212.

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The work presented in this thesis deals with the analysis of protein crystal structures with an emphasis on the stereochemical aspects of the folded conformation of proteins. The various analyses described have been performed on a data-set of 250 high resolution and non-homologous protein structures derived from the Protein Data Bank. The overall objective of the work has been to analyse conformational features of the non-secondary structural regions in proteins and identify structural motifs present therein. The results can be useful in the three-dimensional modelling of proteins, altering th

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33

Nadal, Serrano Mercedes. "Efectos de los Estrógenos, la Genisteína y la Leptina sobre el Estrés Oxidativo en el Cáncer de Mama. Importancia de la UCP2." Doctoral thesis, Universitat de les Illes Balears, 2014. http://hdl.handle.net/10803/284237.

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El estrés oxidativo es un desequilibrio entre la producción de radicales libres y los sistemas antioxidantes encargados de su neutralización. El resultado de este desequilibrio es la acumulación de daños en diversas estructuras celulares incluyendo el DNA. El cáncer se acompaña de un mayor estrés oxidativo a nivel celular, por este motivo, muchos de los tratamientos terapéuticos van dirigidos a aumentar los niveles citotóxicos de ROS, conduciendo a la célula tumoral a la apoptosis. Sin embargo, durante la tumorigénesis las células van adquiriendo una serie de características que permiten mante

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34

Gackowska, Agata. "Cloning and expression analysis of leptin and its receptor in the axolotl (Ambystoma mexicanum)." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1415.

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Since its discovery in 1994, the adipose tissue hormone leptin has been well established as a key regulator of energy balance in mammals. However, little is known about the molecular evolution of the hormone and its function in non-mammalian vertebrates. This project builds on the recent identification of leptin in an amphibian, the tiger salamander, to investigate the leptin signalling system in a laboratory salamander, the axolotl. The overall aim of the project was to obtain cDNA sequences of the axolotl leptin and leptin receptor (LEPR) genes, to analyse their expression and to study their

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35

Heshka, Jodi T. "Effects of dietary fat type and energy restriction on hypothalamic membrane structure and leptin receptor function." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33001.

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The objectives of the present study were to examine the effects of dietary fat type and level of energy intake on hypothalamic leptin binding affinity and membrane fatty acid composition, circulating leptin levels, and body weight homeostasis in rats. Animals were fed diets containing tallow, safflower oil, or menhaden oil (20% wt/wt) for 10 wks, ad libitum or at 60% of ad libitum intakes. Specific leptin binding could not be detected in hypothalamic membrane homogenates; hypothalamic leptin levels were unaffected by diet or energy intake. Levels of tracer exceeding assay reference values were

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36

Okita, Michi. "Ablation of Estrogen receptor alpha (ERα) prevents upregulation of POMC expression by leptin and insulin". Kyoto University, 2011. http://hdl.handle.net/2433/142079.

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37

Ebihara, Ken. "Involvement of Agouti-Related Protein, an Endogenous Antagonist of Hypothalamic Melanocortin Receptor, in Leptin Action." Kyoto University, 2000. http://hdl.handle.net/2433/180876.

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38

Trombley, Susanne. "Regulation of Leptin by Sexual Maturation and Energy Status in Male Atlantic Salmon (Salmo salar L.) Parr." Doctoral thesis, Uppsala universitet, Jämförande fysiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223462.

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Leptin is a peripheral adiposity signal and a key hormone in energy balance regulation in mammals, acting as a link between nutritional status and the endocrine reproductive axis. If this is also the role of leptin in fish is not fully understood. This thesis investigates how different components of the leptin system are affected by sexual maturation and seasonal changes in energy balance in male Atlantic salmon (Salmo salar L.) parr under fully fed and feed-restricted conditions. Moreover, the role of sex steroids as being one of the possible mechanisms by which sexual maturation interacts wi

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Hilzendeger, Aline Mourão [UNIFESP]. "Efeitos da obesidade no sistema calicreína-cininas: estudo dos receptores B1 e B2 de cininas em tecido adiposo humano e murino." Universidade Federal de São Paulo (UNIFESP), 2006. http://repositorio.unifesp.br/handle/11600/9445.

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Made available in DSpace on 2015-07-22T20:50:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-06-28. Added 1 bitstream(s) on 2015-08-11T03:25:41Z : No. of bitstreams: 1 Publico-091.pdf: 651136 bytes, checksum: 35401eae81afb55be34c6f47a332e47e (MD5)<br>Objetivo: Estudar o efeito da obesidade na regulação do sistema calicreína-cininas por meio da expressão dos receptores B1 e B2 de cininas em humanos e camundongos, e as alterações na síntese e funcionalidade dos receptores em tecidos murinos. Métodos: Foram coletados tecido adiposo branco humano e diferentes tecidos de camundongo. D

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Ikeda, Atsuyuki. "Leptin Receptor Somatic Mutations are Frequent in HCV-Infected Cirrhotic Liver and Associate with Hepatocellular Carcinoma." Kyoto University, 2014. http://hdl.handle.net/2433/188668.

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Macêdo, Luã Barbalho de. "Imunolocalização de receptores de leptina no ovário de preás (Galea spixii Wagler, 1831)." Programa de Pós-Graduação em Ciência Animal, 2017. http://bdtd.ufersa.edu.br:80/tede/handle/tede/637.

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Submitted by Socorro Pontes (socorrop@ufersa.edu.br) on 2017-03-30T14:58:19Z No. of bitstreams: 1 LuãBM_DISSERT.pdf: 1732522 bytes, checksum: 8ab1e4a3686c8d21f9bc08fcc449f393 (MD5)<br>Made available in DSpace on 2017-03-30T14:58:20Z (GMT). No. of bitstreams: 1 LuãBM_DISSERT.pdf: 1732522 bytes, checksum: 8ab1e4a3686c8d21f9bc08fcc449f393 (MD5) Previous issue date: 2017-02-16<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Leptin, a cytokine produced by adipose cells, is the target of the scientific community for believing that it has an impact on the reproduction of the anima

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Emancipator, Douglas Steven. "The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504.

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SILVA, Núbia Michelle Vieira da. "Polimorfismo genético da leptina e do receptor do hormônio do crescimento em caprinos." Universidade Federal Rural de Pernambuco, 2010. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6851.

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Submitted by (lucia.rodrigues@ufrpe.br) on 2017-05-09T15:47:00Z No. of bitstreams: 1 Nubia Michelle Vieira da Silva.pdf: 1519635 bytes, checksum: 28fb82a2e5ac497c9fefcd231c2cf135 (MD5)<br>Made available in DSpace on 2017-05-09T15:47:00Z (GMT). No. of bitstreams: 1 Nubia Michelle Vieira da Silva.pdf: 1519635 bytes, checksum: 28fb82a2e5ac497c9fefcd231c2cf135 (MD5) Previous issue date: 2010-06-23<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>This study aimed to avaluate the relationship the polymorphism from the leptin gene (LEP), specifically exon 2, a

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Wang, Mengjie. "Brain Insulin-Like Growth Factor 1 Receptor and Insulin Receptor in Metabolism and Reproduction." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1564676824418256.

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Zetouni, Larissa [UNESP]. "Polimorfismo nos genes da leptina e do receptor de melatonina em búfalas (Bubalus bubalis)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/92580.

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Made available in DSpace on 2014-06-11T19:26:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-04-25Bitstream added on 2014-06-13T20:54:06Z : No. of bitstreams: 1 zetouni_l_me_jabo.pdf: 337751 bytes, checksum: b21af7c1ec9b43b60d9345d076668d73 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O gene responsável pela codificação do hormônio leptina tem sido associado à produção de leite, e diversos polimorfismos encontrados nesse gene foram associados a características produtivas em bovinos. O objetivo do presente estudo foi a identificação do polimorfismo

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Zetouni, Larissa. "Polimorfismo nos genes da leptina e do receptor de melatonina em búfalas (Bubalus bubalis) /." Jaboticabal : [s.n.], 2012. http://hdl.handle.net/11449/92580.

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Orientador: Humberto Tonhati<br>Coorientador: Marcelo Cervini<br>Banca: Maria Elisabete Jorge Amaral<br>Banca: Joslaine Noely dos Santos Gonçalves Cyrillo<br>Resumo: O gene responsável pela codificação do hormônio leptina tem sido associado à produção de leite, e diversos polimorfismos encontrados nesse gene foram associados a características produtivas em bovinos. O objetivo do presente estudo foi a identificação do polimorfismo LEP-1620 (A/G) no gene bubalino da leptina e suas possíveis associações com as produções de leite, gordura, proteína e porcentagens de gordura e proteína. Foram colet

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Hanif, Shahid. "Quantitative expression of genes involved in the leptin receptor-mediated STAT signalling pathway in rodent models of obesity." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272872.

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Wilsey, Jared Timothy. "Potent anorexic and lipopenic effects of central leptin gene therapy are blocked by diet-induced obesity evidence for impaired leptin receptor expression/signal transduction in obesity and reversal by caloric restriction /." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000970.

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Kuo, Alice Yi-Wen. "Genomic and Physiological Differences for Ghrelin and Leptin Receptor in Lines of Chickens Selected for High and Low Body Weight." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/30045.

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Autonomic nervous system (ANS) activity is related to body weight regulation. Based on the hypothesis that Most Obesities kNown Are Low In Sympathetic Activity (MONA LISA), it has been suggested that most obese subjects and animals have low sympathetic nervous system activity. Leptin, leptin receptor, and ghrelin genes influence the ANS regulation of body weight and food intake. The aim of this study was to investigate whether there are differences in leptin, the leptin receptor, or ghrelin regulation between lines of chickens selected for high (HWS) or low body weight (LWS). Intraperitoneal

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MOCIÑO, RODRIGUEZ MARTHA DANIELA 701361, and RODRIGUEZ MARTHA DANIELA MOCIÑO. "Expresión de los receptores adipor1 y adipor2 como mecanismo de regulación leptina-cáncer de mama." Tesis de maestría, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/67709.

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La obesidad es uno de los factores más reconocidos en el desarrollo del cáncer de mama, y el tejido adiposo juega un papel muy importante en esta patología debida la secreción de sus diversas citosinas, principalmente Leptina y Adiponectina. La base molecular de esta asociación no es bien conocida y muy pocos son los que han estudiado a los receptores de Adiponectina (AdipoR1 y AdipoR2) y la influencia de la Leptina sobre ellos. Por lo que se requiere elucidar los mecanismos por los cuales niveles altos de Leptina en el organismo generan un aumento en el riesgo de desarrollo de cáncer de mama

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