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Дисертації з теми "Linear accelerators in medicine"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 29 січня 2023

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1

Klick, George. "High-technology, high energy medical linear accelerators : a review of contemporary problems." Thesis, Queensland University of Technology, 1989. https://eprints.qut.edu.au/35939/1/35939_Klick_1989.pdf.

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The original aim of this project was to study the factors affecting the decision to adopt high energy linear accelerators. including administrative. technical and cltnical aspects. However the potential enormity of the task soon became evident resulting in limitations being placed on the scope of the study. The group of topics finally chosen as the basis for this review-study (listed below) were principally derived from those nominated in the paper by Drew (1987): 1. Optimum Accelerator Energy 2. Aspects of Photon and Electron Dosimetry 3. Dose Delivery Errors 4. Computer Control Systems

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2

Delaney, Geoffrey Paul SWSAHS Clinical School UNSW. "The Development of a New Measure of Linear Accelerator Throughput in Radiation Oncology Treatment Delivery - The Basic Treatment Equivalent (B.T.E.)." Awarded by:University of New South Wales. SWSAHS Clinical School, 2001. http://handle.unsw.edu.au/1959.4/33381.

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The measurement of productivity in health care is difficult. Studies in various specialty disciplines of medicine have identified that the variation in complexities (casemix) between departments or hospitals will vary and therefore will affect any basic productivity statistics that are produced. Radiation oncology is a discipline of medicine where no such studies into radiotherapy casemix variations and the effect that these may have on productivity measures have been performed, despite the high capital expenditure involved in the delivery of radiotherapy. Radiation oncology productivity on l

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3

Satory, Philip Reynard. "An Investigation into EPID Flood Fields Independent from the Linear Accelerator Beam." Thesis, University of Canterbury. Physics and Astronomy, 2008. http://hdl.handle.net/10092/2185.

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The EPID (electronic portal imaging device) was designed for in vivo imaging of patients during radiotherapy treatment. The ability of EPIDs to promptly acquire two dimensional data, lends them to be considered for use in quality assurance of the linac. This thesis set out to investigate the possibility of using a radionuclide, technetium 99 m (Tc99m), to produce a flood field for the calibration of an EPID, because using a beam calibrated EPID to measure the beam is self-referential. The difference in relative response between the energy spectrum of a 6MV beam and the Tc99m was investigate

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4

Cashmore, Jason. "Operation, characterisation & physical modelling of unflattened medical linear accelerator beams and their application to radiotherapy treatment planning." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4616/.

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The flattening filter is a conical shaped piece of metal sitting within the treatment head of a linear accelerator, used to produce a flat, uniform beam of X-rays from the forward-peaked distribution exiting the target. Despite their routine use since the introduction of the linac in the 1950’s, however, there are still several unresolved issues surrounding their use. The photon scatter and electron contamination introduced by modifying the fluence are difficult to model, as is the variation in energy spectrum caused by differential absorption across the field. Leakage radiation also causes in

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5

Horne, Christopher Douglas. "Design and analysis of linear induction accelerators." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309929.

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6

Crossman, John S. P. "Microdosimetry of photoneutrons around medical linear accelerators." Thesis, University of St Andrews, 1997. http://hdl.handle.net/10023/13366.

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Photoneutrons produced in the vicinity of medical linear accelerators for therapy, constitute a hazard which is difficult to assess and monitor. The aims of the project were to develop new techniques, using microdosimetry, which would be suitable for the improved quality control of pulsed photon beams and for the assessment of the associated photoneutron hazard in typical treatment facilities from the perspective of the patients and staff. The measurements of photoneutron yields and equivalent doses were obtained using activation analysis detectors around a 10 MV LINAC. To obtain adequate stat

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7

Plostinar, Ciprian. "Design principles for high power linear accelerators." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:c425c3c8-772c-49a0-8764-257ae6af5bd6.

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The demand for high power proton beams is at an all time high. The global community has identified many applications ranging from spallation sources, material irradiation facilities and secondary beams factories to accelerator driven systems for energy production, transmutation of waste or production of tritium. The typical path to high power beams involves the use of a linac at least in the lower energy stages. For high intensity, high power operation, significant developments are needed particularly in the linac section and the front end of the machine. Consequently, this thesis brings origi

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8

Wang, Yi Zhen 1965. "Photoneutrons and induced activity from medical linear accelerators." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81453.

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This study involves the measurement of the neutron equivalent dose ( NED) and the induced activity produced from medical linear accelerators. For the NED, various parameters such as the profile, field effects and energy responses were studied. The NED in a Solid Water(TM) phantom was measured and a new quantity, the neutron equivalent dose tissue-air ratio (NTAR), was defined and determined. Neutron production for electron beams was also measured. For the induced activity, comparisons were carried out between different linacs, fields and dose rates. The half life and activation saturati

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9

Taheri, Faissal Bakkali. "Numerical and experimental studies of coherent Smith-Purcell radiation." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:d483c501-ba46-4e08-9d38-5af29211aedc.

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This thesis investigates the properties of coherent Smith-Purcell radiation (cSPr) at femtosecond-scale in the case of electrons bunches in the ultrarelativistic regimes. Of particular interest is the use of cSPR as a diagnostic tool to determine the longitudinal time profiles of such bunches, the study of azimuthal distribution of the radiated energy, and a contribution to the understanding of polarization properties. The study consists in a first theoretical part carried mostly in the context of the surface-current theory, supported with insights from particle-in-cell simulations. Then, as a

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10

Rodríguez, Castillo Miguel Lázaro. "Automation of the Monte Carlo simulation of medical linear accelerators." Doctoral thesis, Universitat Politècnica de Catalunya, 2016. http://hdl.handle.net/10803/392626.

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The main result of this thesis is a software system, called PRIMO, which simulates clinical linear accelerators and the subsequent dose distributions using the Monte Carlo method. PRIMO has the following features: (i) it is self- contained, that is, it does not require additional software libraries or coding; (ii) it includes a geometry library with most Varian and Elekta linacs; (iii) it is based on the general-purpose Monte Carlo code PENELOPE; (iv) it provides a suite of variance-reduction techniques and distributed parallel computing to enhance the simulation efficiency; (v) it is graphica

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11

GUIMARÃES, NILMARA ALMEIDA. "METROLOGICAL EVALUATION OF THE RADIATION FIELD SIZE BY LINEAR ACCELERATORS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2011. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34951@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO<br>O objetivo desta dissertação é o estudo de procedimentos para avaliação da confiabilidade metrológica do tamanho de campo irradiado (TCI) por aceleradores lineares. No contexto das recentes alterações no panorama regulamentar dos serviços de radioterapia, com a implementação da RDC número 20, em 2006, pela Agência Nacional de Vigilância Sanitária (ANVISA), foi estabelecida a compulsoriedade do uso do densitômetro óptico na verificação do TCI, como parte do controle da qualidad

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12

Garland, James Matthew. "Beam dynamics studies of the EMMA linear non-scaling FFAG." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/beam-dynamics-studies-of-the-emma-linear-nonscaling-ffag(5b375a2d-0636-422d-a0d6-2cc941ebd01f).html.

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The development of charged particle accelerators is today reaching far beyond the realm of fundamental particle physics research. Many non-trivial social and political problems may find part of their solution lies in accelerator physics. For example, with fossil fuels becoming ever more controversial and expensive to obtain, the use of Accelerator Driven Sub-critical Reactors (ADSR) powered by rapid cycling, high current proton accelerators and thorium fuel could become part of the energy solution. Through the simplicity of the Bragg peak, cancer therapy could be enhanced through the use of hi

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13

Malysheva, Larisa Ivanovna. "Numerical investigation of spin dynamics problems in linear and circular accelerators." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539513.

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14

Thien, Joseph R. "High order parametric x-radiation from silicon and lithium fluoride crystal monochromators." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1995. http://handle.dtic.mil/100.2/ADA305981.

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15

Sheikh-Bagheri, Daryoush. "Monte Carlo study of photon beams from medical linear accelerators, optimization, benchmark and spectra." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ37077.pdf.

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16

PASSARO, BRUNO M. "Análise quantitativa dos resultado dos testes de controle de qualidade em radioterapia." reponame:Repositório Institucional do IPEN, 2011. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10038.

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Made available in DSpace on 2014-10-09T12:34:04Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:59:54Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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17

Assatel, Omran. "Characterisation of photon and neutron spectra in medical linear accelerators using theoretical and experimental techniques." Thesis, University of Surrey, 1996. http://epubs.surrey.ac.uk/804743/.

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18

Davis, Michael Roger. "The development of intra-train beam stabilisation system prototypes for a future linear collider." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:1373c535-b1e3-43d2-8dbf-98a2b6fba6e2.

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Any future linear collider requires a beam stabilisation system at the interaction point to the to maintain luminosities. This thesis details the development of prototypes of three such systems based at the Accelerator Test Facility 2 (ATF2) at KEK, Japan. The upstream feedback system utilises two stripline beam position monitors (BPMs) and two stripline kickers located in the ATF2 extraction line to stabilise the position and angle of the beam; the correction is then measured downstream at the ATF2 beam waist by a cavity BPM. The feedforward system uses the two upstream stripline BPMs to meas

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19

Bakken, Jonas Sjolte. "Study and development of Solid State based Long Pulse Klystron Modulators for future Linear Accelerators at CERN." Thesis, Norwegian University of Science and Technology, Department of Electrical Power Engineering, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-9640.

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<p>A new Klystron modulator is to be developed as a part of the new Linear Accelerator (LINAC4) project that is currently running at CERN. The Klystron modulator is required to supply a pulsed output voltage of -100 kV / 20 A with a repetition rate of 2 Hz and a pulse length of 800 us. In addition to this, the Klystron modulator must also handle arcing in the Klystron, and allow for no more than 10 J of energy to be dissipated in the arc in such a case. This thesis studies possible solid state based topologies that could be relevant for the Klystron modulator. A single switch topology, based

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20

Soubra, Mazen Ahmed. "Linac head scatter factor for asymmetric radiation field." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ26868.pdf.

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21

Al-Shantaf, Abdulraouf O. "A Computer-Based Process Control System for a Target Station in a LINAC Facility." Thesis, University of North Texas, 1999. https://digital.library.unt.edu/ark:/67531/metadc278077/.

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An event-driven, sequential, process control system was designed for International Isotopes, Inc., to automate and remotely control a target station at the company's linear accelerator facility. The designed system consisted of two major sections: a software program (virtual instrument), which was developed by LabVIEW, and a hardware interface (FieldPoint Modular Distributed I/O System by National Instrument), which had to be a pre-developed system that did not require customization. The designed virtual instrument was tested on a simulation model that mimed the target station. The result was

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22

Mears, Michael Laine. "Geometry estimation and adaptive actuation for centering preprocessing and precision measurement." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-03312006-125319/.

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Thesis (Ph. D.)--Mechanical Engineering, Georgia Institute of Technology, 2006.<br>Dr. Richard F. Salant, Committee Member ; Dr. Shreyes N. Melkote, Committee Member ; Dr. Francis M. Kolarits, Committee Member ; Dr. Jane C. Ammons, Committee Member ; Dr. Thomas R. Kurfess, Committee Chair.

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23

NONATO, FERNANDA B. C. "Projeto, construção e caracterização de sistemas de referência para feixes de elétrons de aceleradores clínicos." reponame:Repositório Institucional do IPEN, 2014. http://repositorio.ipen.br:8080/xmlui/handle/123456789/23232.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2015-01-07T16:00:13Z No. of bitstreams: 0<br>Made available in DSpace on 2015-01-07T16:00:14Z (GMT). No. of bitstreams: 0<br>Tese (Doutorado em Tecnologia Nuclear)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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24

Weathersby, Stephen. "Damping higher order modes in the PEP-II B-factory storage ring collider." Diss., Connect to online resource - MSU authorized users, 2007.

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Анотація:

Thesis (Ph.D.)--Michigan State University. Dept. of Physics and Astronomy, 2007.<br>Title from PDF t.p. (viewed on August 18, 2009) Includes bibliographic references (p. 175-179). Also issued in print.

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25

BERDAKY, MAFALDA F. "Implantacao de um servico de radioterapia com acelerador linear (fotons): testes de aceitacao, dosimetria e controle de qualidade." reponame:Repositório Institucional do IPEN, 2000. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10873.

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Made available in DSpace on 2014-10-09T12:44:57Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:00:41Z (GMT). No. of bitstreams: 1 07002.pdf: 4288573 bytes, checksum: c18927c21f315b4f8c58d377e6d345ca (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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26

Metral, Elias. "Coupled Landau damping of transverse coherent instabilities in particle accelerators." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10048.

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L'effet du couplage lineaire entre les plans transversaux d'un accelerateur circulaire sur l'amortissement de landau des instabilites coherentes est etudie en considerant deux distributions caracteristiques de frequences (lorentzienne et elliptique). Celles-ci correspondent a des cas limites modelisant des spectres avec et sans longues queues. Un critere general de stabilite, ou interviennent la force du couplage (du aux quadrupoles tournes) et la distance des nombres d'ondes betatroniques aux resonances de couplage, est obtenu dans les deux cas. Ce dernier revele la possibilite de partager le

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27

Blaskovic, Kraljevic Neven. "Development of a high-precision low-latency position feedback system for single-pass beamlines using stripline and cavity beam position monitors." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:0286d951-d177-4d3a-8bce-a50e6ccb8645.

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The FONT beam-based, intra-train feedback system has been designed to provide beam stability at single-pass accelerators, such as at the interaction point (IP) of the International Linear Collider. Two FONT feedback systems have been commissioned at the Accelerator Test Facility (ATF) at KEK, Japan, and the operation, optimisation and performance of these systems is the subject of this thesis. For each system, the accelerator is operated with two-bunch trains with a bunch separation of around 200 ns, allowing the first bunch to be measured and the second bunch to be subsequently corrected. The

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28

Bromwich, Talitha. "Development of high-resolution cavity beam position monitors for use in low-latency feedback systems." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:7d3fada0-2676-4983-8e2c-16d2d6d4f7d0.

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The FONT beam-based, intra-train feedback system has been designed to provide beam position stabilisation in single-pass accelerators. A FONT feedback system utilising position information from three high-resolution cavity beam position monitors (BPMs) has been commissioned at the interaction point (IP) of the Accelerator Test Facility 2 (ATF2) at KEK, Japan. The ultimate goal of the feedback in the IP region is to stabilise the low-emittance electron beam to the nanometre level. The operation, optimisation and resolution performance of this IP system forms the subject of this thesis. The IP f

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29

Murray, Iain. "Application of the Linear-Quadratic model to targeted radionuclide therapy." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2684.

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The principal aim of this work was to test the hypothesis that the Linear-Quadratic (LQ) model of cell survival, developed for external beam radiotherapy (EBRT), could be extended to targeted radionuclide therapy (TRT) in order to predict dose-response relationships. The secondary aim was to establish the relevance of particular radiobiological phenomena to TRT and relate these results to any deviations from the response predicted by the LQ Model. Methods: Cancer cell lines were treated with either EBRT or an in-vitro model of TRT. Dosimetry for the TRT was calculated using radiation transport

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30

Jolly, Simon. "An intra-pulse fast feedback system for a future linear collider." Thesis, University of Oxford, 2003. http://ora.ox.ac.uk/objects/uuid:3e17d216-7430-4869-9873-4a469fa9c4c5.

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An intra-pulse Interaction Point fast feedback system (IPFB) has been designed for the Next Linear Collider (NLC), to correct relative beam-beam misalignments at the Interaction Point (IP). This system will utilise the large beam-beam kick that results from the beam-beam interaction and apply a rapid correction to the beam misalignment at the IP within a single bunch train. A detailed examination of the IPFB system is given, including a discussion of the necessary electronics, and the results of extensive simulations based on the IPFB concept for fast beam correction are presented. A recovery

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31

Silva, Ricardo Goulart da. "Desenvolvimento de um programa de controle da qualidade para a tecnologia VMAT." Universidade Tecnológica Federal do Paraná, 2013. http://repositorio.utfpr.edu.br/jspui/handle/1/727.

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A radioterapia moderna continua evoluindo e trazendo mudanças tecnológicas que envolvem novas modalidades de imagem, novos acessórios de imobilização e novos sistemas para a entrega da dose. Esses avanços possibilitam reduzir a dose recebida pelos tecidos sadios e, consequentemente, diminuem o risco de toxicidade e morbidade. Ao mesmo tempo, maiores doses podem ser prescritas para os volumes tumorais, o que aumenta a probabilidade de controle locorregional. Técnicas tradicionais de IMRT oferecem todas essas vantagens, porém, o tempo de cada sessão de tratamento costuma ser muito longo, princip

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32

POLI, MARIA E. R. "Dosimetria aplicada na irradiacao de toda a pele utilizando feixes de eletrons com energia nominal de 4 MeV." reponame:Repositório Institucional do IPEN, 2000. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10813.

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Made available in DSpace on 2014-10-09T12:44:18Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:07:24Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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33

Rao, Arati. "Therapeutic strategies for restoring linear growth in children with Crohn's disease." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9005.

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Linear growth retardation affects up to 40% of children with Crohn’s disease (CD). It is caused by a combination of under\nutrition, and by a direct effect of cytokines on the axis linking human growth hormone (GH), insulin like growth factor\1 (IGF\1) and the growth plate of growing bones. In particular,the inflammation causes a functional insensitivity to GH, resulting in low circulating IGF\1. Current management is synonymous with the optimal management of childhood CD:to eliminate inflammation,and maintain remission. However, there is currently no consensus as to how to treat growth failur

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34

Montanari, Carlo Emilio. "Diffusive approach for non-linear beam dynamics in a circular accelerator." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19289/.

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Nella fase di design e simulazione di un acceleratore circolare, risulta fondamentale avere una buona comprensione del moto betatronico non-lineare delle singole particelle, e di come questo interferisce con la qualità del fascio. In questo lavoro vengono studiati sistemi Hamiltoniani sottoposti a perturbazioni stocastiche tramite un framework diffusivo, basato sull'equazione di Fokker-Planck. Tale studio viene poi applicato all'analisi del moto betatronico non-lineare e al problema dell'Apertura Dinamica. In particolare, vengono impostate le basi per formulare un metodo di interpolazione di

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35

TORETI, DALILA L. "Aceite, comissionamento e controle de qualidade em radiocirurgia." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9479.

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Made available in DSpace on 2014-10-09T12:27:10Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:57:19Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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36

FONSECA, GABRIEL P. "Projeto e construcao de placas espalhadoras e degradadoras de energia para uso em radioterapia com feixe de eletrons para doencas de pele." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9550.

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Made available in DSpace on 2014-10-09T12:27:55Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:59:32Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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37

Russman, Felipe Boff. "Quebra de dinâmica ponderomotiva como um eficiente mecanismo de aceleração e focagem de partículas carregadas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/174847.

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A presente dissertação estuda a dinâmica uni e tridimensional de uma part cula solitária eletricamente carregada sob a ação de uma onda eletrostática de alta frequência lentamente modulada. A onda dota a partícula de energia potencial elétrica e o seu movimento e conhecido através do emprego do formalismo hamiltoniano, onde se faz a consideração de efeitos relativísticos devido as altas velocidades envolvidas no processo. Enquanto a velocidade máxima experimentada pela partícula permanece suficientemente abaixo da velocidade de fase característica da onda que a acelera, sua dinâmica pode ser b

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Cengiz, Mehmet Ali. "Contributions to the development and analysis of multivariate generalized linear models, with application to the diagnosis of arterial occlusive disease." Thesis, University of Salford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265738.

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39

Lundgren, Maria. "Born Small for Gestational Age : Impact of Linear Catch-up Growth." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl.[distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3563.

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Stephenson, John. "Multilevel generalised linear modelling and competing risks multistate survival analysis modelling of childhood caries." Thesis, Cardiff University, 2009. http://eprints.hud.ac.uk/7910/.

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There has been an ongoing debate regarding appropriate strategies for the management of carious primary teeth. Studies appear to provide evidence that both selective, symptom-based interventions and traditional restorative strategies are advantageous. However, the analysis and quantification of childhood caries may be affected by clustering of data, and the concurrent risk of exfoliation of primary teeth. Multilevel generalised linear models for the occurrence of primary caries were derived utilising data from a cohort study of 2,654 children aged 4-5 years at baseline undertaken 1999-2003. Th

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41

VIEIRA, ANDRÉ M. de M. "Dosimetria dos sistemas de radiocirurgia estereotáxica com aceleradores lineares equipados com colimadores micro multi-lâminas." reponame:Repositório Institucional do IPEN, 2008. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11608.

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Made available in DSpace on 2014-10-09T12:53:49Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:58:49Z (GMT). No. of bitstreams: 0<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP

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42

Tsirakos, Dimitrios Konstantinos. "Biomechanical analysis of a ballistic throwing task under different loading conditions using non-linear optimisation methods." Thesis, Manchester Metropolitan University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266789.

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43

Barons, Martine J. "What is the added value of using non-linear models to explore complex healthcare datasets?" Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/58401/.

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Health care is a complex system and it is therefore expected to behave in a non-linear manner. It is important for the delivery of health interventions to patients that the best possible analysis of available data is undertaken. Many of the conventional models used for health care data are linear. This research compares the performance of linear models with non-linear models for two health care data sets of complex interventions. Logistic regression, latent class analysis and a classification artificial neural network were each used to model outcomes for patients using data from a randomised c

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44

Arthofer, Christoph. "Multi-atlas segmentation using clustering, local non-linear manifold embeddings and target-specific templates." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50070/.

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Multi-atlas segmentation (MAS) has become an established technique for the automated delineation of anatomical structures. The often manually annotated labels from each of multiple pre-segmented images (atlases) are typically transferred to a target through the spatial mapping of corresponding structures of interest. The mapping can be estimated by pairwise registration between each atlas and the target or by creating an intermediate population template for spatial normalisation of atlases and targets. The former is done at runtime which is computationally expensive but provides high accuracy.

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GONCALVES, VINICIUS D. "Caracterização da dose em pacientes devido a produção de imagem de raios-X utilizadas em radioterapia guiada por imagem - IGRT." reponame:Repositório Institucional do IPEN, 2014. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10555.

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Made available in DSpace on 2014-10-09T12:41:52Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:08:40Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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46

Rosencranz, Daniela Necsoiu. "Monte Carlo simulation and experimental studies of the production of neutron-rich medical isotopes using a particle accelerator." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3077/.

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The developments of nuclear medicine lead to an increasing demand for the production of radioisotopes with suitable nuclear and chemical properties. Furthermore, from the literature it is evident that the production of radioisotopes using charged-particle accelerators instead of nuclear reactors is gaining increasing popularity. The main advantages of producing medical isotopes with accelerators are carrier free radionuclides of short lived isotopes, improved handling, reduction of the radioactive waste, and lower cost of isotope fabrication. Proton-rich isotopes are the result of nuclear inte

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47

Choudhury, Tisha. "Delineating key genetic components on linear plasmid 36 that contribute to its essential role in Borrelia burgdorferi mammalian infectivity." Doctoral diss., University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5916.

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The spirochete Borrelia burgdorferi is the etiologic agent of Lyme disease. This pathogen has a complex enzootic life cycle that involves passage between the tick vector (Ixodes scapularis) and various vertebrate hosts with humans being inadvertent hosts. There is a pressing need to study the genetic aspects of the B. burgdorferi infectious cycle and particularly spirochete genes involved in mammalian infectivity so as to develop novel therapeutic and diagnostic strategies to combat Lyme disease. The B. burgdorferi genome is fragmented and comprised of a single 900 kb linear chromosome and mul

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Arpad, Tot. "Karakterizacija fotona i neutrona megavoltažnih terapijskih akceleratora." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107144&source=NDLTD&language=en.

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Poznavanje spektra x-zračenja kao i drugih osobina je od izuzetnog  značaja  kako za planiranje radijacione terapije tako i sa aspekta za&scaron;tite pacijenta i osoblja. Takođe, poznavanje svojstava  neutrona  nastalih  u interakciji fotona sa materijalimaoko akceleratora, je od izuzetnog značaja sa dozimetrijskog aspekta. Poslednjih godina sve se vi&scaron;e upotrebljavaju linearni akceleratori bez homogenizacionog filtera tzv. FFF (<em>Flatteninig Filter Free</em>), a kako su karakteristike snopa u toma načinu rada akceleratora jo&scaron; uvek nedovoljno ispitane, n

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TERREMOTO, LUIS A. A. "Eletrodesintegração do sup(232)Th por emissão de um nêutron." reponame:Repositório Institucional do IPEN, 1986. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11629.

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Made available in DSpace on 2014-10-09T12:54:05Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:09:02Z (GMT). No. of bitstreams: 1 12444.pdf: 2861377 bytes, checksum: f197a83330e61c5fa6654676c3363a7f (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Fisica, Universidade de Sao Paulo - IF/USP

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Wang, Ling, Yujia Wang, Juan Zhao, Junping Ren, Kenton H. Hall, Jonathon P. Moorman, Zhi Q. Yao та Shunbin Ning. "The Linear Ubiquitin Assembly Complex Modulates Latent Membrane Protein 1 Activation of NF-κB and Interferon Regulatory Factor 7". Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/6529.

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Recently, linear ubiquitin assembly complex (LUBAC)-mediated linear ubiquitination has come into focus due to its emerging role in activation of NF-κB in different biological contexts. However, the role of LUBAC in LMP1 signaling leading to NF-κB and interferon regulatory factor 7 (IRF7) activation has not been investigated. We show here that RNF31, the key component of LUBAC, interacts with LMP1 and IRF7 in Epstein-Barr virus (EBV)-transformed cells and that LUBAC stimulates linear ubiquitination of NEMO and IRF7. Consequently, LUBAC is required for LMP1 signaling to full activation of NF-κB

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