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Дисертації з теми "Lipid signal"

Автор: Grafiati

Опубліковано: 7 липня 2024

Оновлено: 7 липня 2024

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1

Frangioudakis, Georgia St Vincent's Clinical School UNSW. "Insulin signal transduction in vivo in states of lipid-induced insulin resistance." Awarded by:University of New South Wales. St Vincent's Clinical School, 2004. http://handle.unsw.edu.au/1959.4/27419.

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Insulin resistance is the major metabolic defect in obesity and Type 2 diabetes. Increased lipid accumulation is strongly associated with insulin resistance. A significant component of insulin resistance is thought to be a reduced ability of insulin to activate the cascade of phosphorylation events that lead to the metabolic effects of this hormone. The broad aims of this thesis were to examine the effect of high-fat diets containing different fat subtypes on in vivo insulin signalling, under conditions normally used to detect whole body insulin resistance, and to compare the effects of acute

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2

Pott, Markus Philipp. "Organic hydroperoxide-induced lipid peroxidation (LPO) and signal transduction pathways in human keratinocytes." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96545293X.

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3

FEZZA, FILOMENA. "Regulation of endocannabinoid system by lipid rafts along the neuroimmune axis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2006. http://hdl.handle.net/2108/202611.

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L’anandamide (arachidonoiletanolammide, AEA), insieme con l’altro endocannabinoide 2arachidonoilglicerolo (2-AG), lega ed attiva i due recettori accoppiati a proteine G inibitorie, (GPCR), chiamati recettori dei cannabinoidi di tipo-1 (CB1R) e di tipo-2 (CB2R). I CB1R sono localizzati principalmente nel sistema nervoso centrale, ma sono anche espressi in tessuti periferici come le cellule immunitarie. Mentre i CB2R sono maggiormente espressi a livello periferico, ma sono anche presenti nel cervello. Quindi l’attivazione dei recettori CB1 o CB2 da parte dell’AEA e del 2-AG ha molti effetti sia

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4

Sampey, Brante P. "Studies of the adduction of hepatocellular proteins by 4-HNE in animals [sic] models of alcoholic liver disease : systematic analysis of hepatocellular Erk 1/2 modulation and dysregulation of the Erk-Elk-AP1 signal transduction pathway /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Toxicology) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 141-156). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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5

Metcalfe, Maureen Grage. "Two-dimensional crystallization of archaeal signal peptide peptidases for structural studies by electron crystrallography." Thesis, Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53984.

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The membrane proteins signal peptide peptidase, signal peptide peptidase like and presenilin are intramembrane aspartyl proteases located in the endoplasmic reticulum, plasma membrane and organelle. These membrane proteins are able to catalyze a hydrolytic reaction in a hydrophobic space. The downstream consequences of these reactions impact a variety of cellular functions such as cytokine production, inflammatory responses, embryogenesis, and immune system regulation. Additionally, the aspartyl proteases such as signal peptide peptidase and presenilin, a part of the γ-secretase complex, hydro

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6

Lautscham, Lena Astrid [Verfasser], and Ben [Akademischer Betreuer] Fabry. "Cell migration and mechanosensitive signal transduction on 2-dimensional biomembrane-mimicking lipid bilayer stacks and in confined 3-dimensional microstructures / Lena Astrid Lautscham. Gutachter: Ben Fabry." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1076166105/34.

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7

Casiraghi, Marina. "Functional modulation of a G protein-coupled receptor conformational landscape in a lipid bilayer." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC138/document.

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Les récepteurs couplés aux protéines G (GPCRs en anglais) représentent la famille de récepteurs intégrales de membrane plus vaste dans la majorité des cellules eucaryotes. Ils jouent un rôle clé dans la transduction de signal, ainsi que la compréhension de leur mécanisme de signalisation représente une des questions principales dans la biologie d'aujourd'hui. Dans la caractérisation du paysage énergétique de ces récepteurs à l'échelle atomique, les structures cristallographiques publiées pendant la décennie dernière par cristallographie aux rayons X représentent la percée scientifique majeure

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8

Panakova, Daniela. "Lipoprotein particles associate with lipid-linked proteins and are required for long-range Wingless and Hedgehog signaling." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1122025765300-27455.

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Morphogens of the Wnt and Hedgehog families are secreted signaling molecules that coordinate growth and patterning of many different tissues. Both, Wingless and Hedgehog spread across long distances in developing wing of Drosophila melanogaster. However, both proteins are covalently modified with lipid moieties. The mechanisms that allow long-range movement of such hydrophobic molecules are unclear. Like Wingles and Hedgehog, glycosylphosphatidylinositol (gpi)-linked proteins also transfer between cells with their lipid anchor intact. It has been speculated that gpi-linked proteins and lipid-l

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9

Poidevin, Mickaël. "La synthèse d'acides gras dans des cellules spécialisées agit à distance sur le processus d'activation des ovocytes chez la drosophile." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL016.

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Une étude statistique de l'organisation mondiale de la santé a révélé qu'un adulte sur six est concerné par des problèmes d'infertilité. Ce sujet majeur de nos sociétés est complexe, multifactoriel avec une évolution à l'échelle mondiale qui est difficile à évaluer. Il est donc essentiel de mener davantage de recherche pour mieux comprendre l'évolution de l'infertilité, mais aussi les mécanismes cellulaires et moléculaires conduisant à une bonne fertilité.Fortuitement, un crible génétique des enzymes responsables de la synthèse des acides gras dans des cellules spécialisées de la drosophile a

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10

Waterstradt, Katja. "Der Einfluss des Cholesterolgehaltes der Diskmembranen des Stäbchenaußensegmentes auf die ersten Schritte der visuellen Signaltransduktion." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15949.

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Das Außensegment der Stäbchenzelle ist aus einem Stapel von flachen Membransäckchen, den Diskmembranen, aufgebaut. Entlang dessen existiert ein Cholesterolgradient mit 24 mol% Cholesterol in den basalen Diskmembranen und 5 mol% in den apikalen. Das Außensegment enthält alle Proteine der Signaltransduktion. Der Photorezeptor Rhodopsin ist als integrales Membranprotein in die Diskmembran eingebettet. Das G-Protein Transducin und das Effektorprotein, die Phosphodiesterase (PDE), sind periphere Proteine mit Lipidankern und somit reversibel mit der Membranoberfläche assoziiert. Um den Einfluss de

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11

Ravacci, Graziela Rosa. "Desestruturação de lipid rafts por ácido docosaexaenoico (DHA) induz apoptose em células epiteliais luminais da glândula mamária humana transformadas pela superexpressão de HER-2." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-19042013-114655/.

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A superexpressão de receptores HER-2 é anormalidade celular de grande relevância clínica no câncer de mama. Ela ocorre em aproximadamente 30% de carcinomas de mama incluindo lesões pré-neoplásicas e malignas, e está associada a prognóstico desfavorável. A hiperativação dos receptores HER-2, consequência natural de sua superexpressão, promove proliferação celular aberrante e tumorigênese. Admite-se que a ativação e envio de sinais via HER-2 possa acontecer quando estes receptores se encontram em compartimentos específicos da membrana celular, os lipid rafts. Assim, um número maior de HER-2 pode

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12

Tellier, Edwige. "Le TNF alpha : maturation par ADAM-17 et activation d'une voie de signalisation sphingomyéline-céramide." Toulouse 3, 2008. http://thesesups.ups-tlse.fr/725/.

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Le TNF alpha (Tumor Necrosis Factor alpha) est une cytokine pro-inflammatoire existant sous deux formes moléculaires, une forme transmembranaire étant clivée au niveau de la membrane pour générer une forme soluble. Le TNF alpha est impliqué dans de nombreux processus physiologiques et physiopathologiques dont l'athérosclérose. Au sein de la plaque, le TNF alpha soluble semble jouer un rôle majeur : des souris génétiquement modifiées et exprimant exclusivement une forme membranaire non clivable du TNF alpha développent des plaques d'athérosclérose dont l'état inflammatoire est significativement

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13

Edwards, Bethanie Rachele. "The biogeochemistry of lipid derived infochemical signals in the ocean." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103254.

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Thesis: Ph. D., Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Department of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The role of oxylipins in ocean biogeochemistry was investigated using microcosm amendment experiments, environmental lipidomics, and culture based studies. Oxylipins are a bioactive class of secondary metabolites produced by diatoms and other eukaryotic phytoplankton. Previous res

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14

Dove, Stephen K. D. "Inositol lipids and signalling in higher plants." Thesis, University of East Anglia, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338295.

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15

Balogh, Gabor. "Role of membranes in mammalian stress response : sensing, lipid signals and adaptation." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/26933/.

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It was suggested that under heat stress the accumulation of denatured proteins alone triggers the expression of heat shock proteins. However, earlier research suggested that during abrupt temperature fluctuations membranes represent the most thermally-sensitive macromolecular structures. The aim of this thesis to confirm experimentally for the membrane sensor theory in mammalian cells and to explore the mechanisms behind membrane lipid structural reorganizations. The main results are as follows: (i) I provide the first evidence that heat-analogous, chemically-induced membrane perturbation of K

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16

Rogalski, Sherri Lynn. "Modulation of Kir3 by lipids and tyrosine phosphorylation /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6274.

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17

Grimault, Stephan. "Détermination des propriétés du signal RMN par une approche numérique : application aux expériences de diffusion et d'imagerie fonctionnelle." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10157.

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Ce travail etaient est centre sur l'etude et la quantification du signal rmn dans certaines conditions in vivo. Une approche numerique de type monte carlo a ete utilisee. Une premiere etude porte sur la mesure in vivo du coefficient apparent de diffusion (cad) de lipides mobiles detectes dans des tumeurs cerebrales et confines dans des micro-domaines. Le modele numerique permet d'estimer la taille des micro-domaines sur la base du cad mesure. Un diametre de 10 a 12 m a ete trouve, valeur qui concorde avec les etudes par microscopie. Une seconde etudes porte sur la quantification des effets de

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18

Rowe, Daniel C. "Analysis of Toll-Like Receptor 4 Signal Transduction and IRF3 Activation in the Innate Immune Response: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/163.

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Over the last decade, the innate immune system has been the subject of extensive research. Often overlooked by the robustness and specificity of the adaptive immune system, the innate immune system is proving to be just as complex. The identification of several families of pattern recognition receptors (PRRs) has revealed an ancient yet multifaceted system of proteins that are responsible for initiating host defense. A wide array of pathogens, from virus to bacteria, is detected using this assortment of receptors. One such family, the Toll-like receptors (TLRs), has been at the forefront of th

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19

Tolentino, Timothy P. "The Roles of Membrane Rafts in CD32A Mediated Formation of a Phagocytic Contact Area." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16127.

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Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to facilitate the functions of these molecules such as membrane trafficking, receptor transport, cell signaling, and endocytosis. Using laser scanning confocal microscopy and reflection interference microscopy (RIM), we studied the spatial and temporal distributions of membrane rafts and surface receptors, signaling molecules, and cell organelles during t

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20

Hayes, Susan J. "Analysis of FYVE Domain-Containing Proteins in Signaling and Endocytosis: a dissertation." eScholarship@UMMS, 2003. http://escholarship.umassmed.edu/gsbs_diss/208.

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The FYVE domain is a lipid binding domain found in approximately 27 different mammalian proteins. It specifically interacts with the lipid, PI(3)P, which is enriched on early endosomes. Consequently, many FYVE domain-containing proteins localize to the endosome, however the ability of FYVE domains to target to endosomal membranes is variable, despite high sequence conservation. Here we describe the structural requirements necessary for endosomal localization and liposome avidity. As FYVE domains are lipid binding domain, many FYVE domain-containing proteins have been implicated in membrane tra

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21

Hayes, Susan J. "Analysis of FYVE Domain-Containing Proteins in Signaling and Endocytosis: a dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/208.

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The FYVE domain is a lipid binding domain found in approximately 27 different mammalian proteins. It specifically interacts with the lipid, PI(3)P, which is enriched on early endosomes. Consequently, many FYVE domain-containing proteins localize to the endosome, however the ability of FYVE domains to target to endosomal membranes is variable, despite high sequence conservation. Here we describe the structural requirements necessary for endosomal localization and liposome avidity. As FYVE domains are lipid binding domain, many FYVE domain-containing proteins have been implicated in membrane tra

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22

Mitra, Ganguli Tora. "Modulation of Voltage-Gated N-Type Calcium Channels by G Protein-Coupled Receptors Involves Lipids and Proteins: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/389.

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Pain signaling involves transmission of nociceptive stimuli in the spinal cord where a critical balance between excitatory and inhibitory inputs determines the response to noxious stimuli. The neuropeptide, substance P (SP), mediates transmission of pain in part by binding to the tachykinin receptor (NK-1R) in the dorsal horn (DH) of the spinal cord. One of SP’s downstream effects is to modulate N-type Ca2+(N-) channels. While phospholipid breakdown is a part of the inflammatory process that accompanies tissue damage, the role of this metabolic pathway has not been completely described with re

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23

Cazade, Magali. "Nouvelles voies de modulation des canaux calciques de type T." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20106.

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Nouvelles voies de modulation des canaux calciques de type T.Grâce à leur rôle dans l'excitabilité cellulaire et l'homéostasie calcique, les canaux calciques de type T participent à différentes fonctions physiologiques telles que le sommeil ou le contrôle du rythme cardiaque et de la pression artérielle. Ils sont également impliqués dans certaines pathologies comme la douleur ou l'épilepsie. La régulation de l'activité des canaux de type T est encore mal connue et c'est l'enjeu de cette thèse. Dans une première partie, nous avons caractérisé l'effet de certains lipides endogènes sur ces canaux

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24

Rodríguez, Solovey Leisa Natacha. "IDENTIFICATION OF TARGETS AND AUXILIARY PROTEINS OF PYR/PYL/RCAR ABA RECEPTORS: PROTEIN PHOSPHATASES TYPE 2C (PP2Cs) AND C2-DOMAIN ABA-RELATED PROTEINS (CARs)." Doctoral thesis, Universitat Politècnica de València, 2015. http://hdl.handle.net/10251/58862.

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[EN] ABSTRACT Abscisic acid (ABA) signaling plays a critical role in regulating root growth and root system architecture. ABA-mediated growth promotion and root tropic response under water stress are key responses for plant survival under limiting water conditions. In this work, we have explored the role of Arabidopsis (Arabidopsis thaliana) PYR/PYL/RCAR receptors (PYRABACTIN RESISTANCE1 (PYR1)/PYR1 LIKE (PYL)/REGULATORY COMPONENTS OF ABA RECEPTORS) for root ABA signaling. As a result, we discovered that PYL8 plays a nonredundant role for the regulation of root ABA sensitivity. Unexpectedly,

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25

Abdoul-Azize, Souleymane. "Implication de la signalisation calcique et des MAP kinases dans la perception gustative lipidique." Phd thesis, Université de Bourgogne, 2013. http://tel.archives-ouvertes.fr/tel-01018378.

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Dans ce travail, nous démontrons que STIM1, un senseur calcique activé par la déplétion du Ca2+ intracellulaire du réticulum endoplasmique, est indispensable pour la signalisation calcique et la préférence oro-sensorielle du gras. Nous observons que l'acide linoléique (LA), en activant les phospholipases A2 via CD36, produit de l'acide arachidonique (AA) et de la lyso-phosphatidylcholine (lyso-PC). Cette activation déclenche un influx calcique dans les cellules CD36-positives, et induit la production du facteur CIF (Ca2+ Influx Factor). CIF, AA et lyso-PC exercent différentes actions sur l'ouv

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26

Chen, Bo-Cheng, and 陳柏誠. "Validation of lipid contamination elimination using signal space projection on phantom." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/499hwf.

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碩士<br>國立臺灣科技大學<br>電子工程系<br>107<br>Lipid contamination from the intense subcutaneous lipid signal that produces Gibbs ringing artifacts may complicate the quantitation of metabolites in the Magnetic Resonance Spectroscopic Image. In 2D MRSI, lipid suppression is usually achieved by placing 8 outer volume saturation bands (OVS) around the brain with subcutaneous lipids or use inversion recovery to eliminate fat signals. In this study, post-processing method based on spatial signal projection (SSP) was used to achieve the effect of suppressing lipid signal. SSP extracts signal components of lipid

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27

Hooks, Shelley Brown. "Regulation of Lysophosphatidic Acid signaling by Lipid Phosphate Phosphatases /." 2001. http://wwwlib.umi.com/dissertations/fullcit/3000142.

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28

Lu, Li-Ming, and 呂理銘. "Differential signal pathways induced by LPS and Lipid A in human T cells." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/42304161836953702545.

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碩士<br>國立陽明大學<br>生理學研究所<br>91<br>Previous works indicated that Bacterial lipoplysaccharide (LPS) and it's toxically center, lipid A (LA), stimulated NF-κB mRNA expression and NF-κB protein activation, but not the proliferation in T cells. The increasing in intracellular calcium was through phosphoinositide 3-kinase (PI3K) pathway by Lipid A, whereas, the increases in intracellular pH (pHi) was through protein kinase C (PKC)/phospholipase D (PLD) pathway in T cells. Therefore, the aim of this study was to investigate whether gene expression by LPS or LA were regulated by differential signals s

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29

Pott, Markus Philipp [Verfasser]. "Organic hydroperoxide-induced lipid peroxidation (LPO) and signal transduction pathways in human keratinocytes / vorgelegt von Markus Philipp Pott." 2002. http://d-nb.info/96545293X/34.

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30

Walli, Rehab [Verfasser]. "The role of lipid rafts in UVA radiation-induced signal transduction in human keratinocytes / vorgelegt von Rehab Walli." 2009. http://d-nb.info/100104326X/34.

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31

Nelson, Christopher David. "Characterization of Beta-arrestin-Modulated Lipid Kinase Activities for Diacylglycerol and Phosphatidylinositol 4-Phosphate." Diss., 2007. http://hdl.handle.net/10161/206.

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32

Turk, Harmony 1985. "The Role of Docosahexaenoic Acid in Regulation of Epidermal Growth Factor Receptor Activation and Function." Thesis, 2012. http://hdl.handle.net/1969.1/148103.

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The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase integral in regulating cell growth, survival, and migration. EGFR signaling, which is dependent on localization of the receptor within lipid rafts, is often hijacked during colon tumorigenesis. Previous work has found that docosahexaenoic acid (DHA) is protective against colon cancer. This fatty acid is proposed to function in part by perturbing lipid rafts and thereby altering cell signaling. The overall objective of this work was to determine whether DHA alters EGFR function and signaling. We

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33

Li, Pin. "Effects of carbon nanotubes on airway epithelial cells and model lipid bilayers : proteomic and biophysical studies." Thesis, 2014. http://hdl.handle.net/1805/5968.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Carbon nanomaterials are widely produced and used in industry, medicine and scientific research. To examine the impact of exposure to nanoparticles on human health, the human airway epithelial cell line, Calu-3, was used to evaluate changes in the cellular proteome that could account for alterations in cellular function of airway epithelia after 24 h exposure to 10 μg/mL and 100 ng/mL of two common carbon nanoparticles, singleand multi-wall carbon nanotubes (SWCNT, MWCNT). After exposure to the nanoparticles, label-free quantitative

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34

Mar, Fernando José Milhazes. "Novel targets to improve axonal regeneration in the CNS: the role of myelin lipid inhibitors, injury signals and axonal transport." Doctoral thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/75782.

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Mar, Fernando José Milhazes. "Novel targets to improve axonal regeneration in the CNS: the role of myelin lipid inhibitors, injury signals and axonal transport." Tese, 2014. https://repositorio-aberto.up.pt/handle/10216/75782.

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36

(6901280), Brianna N. Hudson. "Insights into the Role of the Membrane on Phospholipase C Beta and G Alpha Q-Mediated Activation." Thesis, 2019.

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Phospholipase Cβ (PLCβ) cleaves phosphatidylinositol-4,5-bisphosphate (PIP<sub>2</sub>) into the second messengers inositol-1,4,5-triphosphate (IP<sub>3</sub>) and diacylglycerol (DAG). IP<sub>3</sub> increases intracellular Ca<sup>2+</sup>, while DAG remains in the membrane, and together with increased Ca<sup>2+</sup>, activates protein kinase C (PKC). PLCβ has low basal activity but is activated following stimulation of G<sub>i</sub>- and G<sub>q</sub>-coupled receptors through direct interactions with Gα<sub>q</sub> and Gβγ. PLCβ is essential for normal cardiomyocyte and vascular smooth mus

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