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Статті в журналах з теми "Lyell's syndrome"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Revuz, J. "Alan Lyell and Lyell's syndrome." Journal of the European Academy of Dermatology and Venereology 22, no. 8 (2008): 1001–2. http://dx.doi.org/10.1111/j.1468-3083.2008.02718.x.

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2

Ivolgina, Irina V. "Surgical treatment of ophthalmological complications in patients with Lyell’s syndrome." Tambov Medical Journal 7, no. 1 (2025): 60–73. https://doi.org/10.20310/2782-5019-2025-7-1-60-73.

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Анотація:

Lyell’s syndrome is a severe disease, a toxic-allergic reaction occurring in 0.3 % of cases of drug allergies. Currently, Lyell's syndrome is considered as a proteolytic reaction with damage to the skin and mucous membranes. Ophthalmological complications observed in patients with Lyell's syndrome are described. During the disease and treatment of pneumonia, a corneal ulcer with perforation appeared in both eyes, which was not relieved by drug treatment. The patients underwent keratoplasty with biological corneal coating according to Kuhnt and bloody blepharorrhea, which made it possible to st

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3

Baroni, Adone, and Eleonora Ruocco. "Lyell's Syndrome." SKINmed: Dermatology for the Clinician 4, no. 4 (2005): 221–25. http://dx.doi.org/10.1111/j.1540-9740.2005.03593.x.

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4

Krivosheev, A. B., T. V. Ermachenko, P. P. Khavin, et al. "Chronic viral infection and toxic epidermal necrolisis (Lyell´s syndrome)." Medical alphabet 1, no. 28 (2022): 15–18. http://dx.doi.org/10.33667/2078-5631-2022-28-15-18.

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Two cases of toxic epidermal necrolysis (Lyell's syndrome) are described. The introduction discusses the relevance of this problem. Emphasis is placed on the differential diagnosis of Lyell's syndrome with Stevens-Johnson syndrome, since both syndromes are difficult to distinguish in the debut. As differential diagnostic criteria, it is recommended to take into account the presence of Nikolsky's symptom and the area of involvement in the pathological process of the skin more than 30%. In the manifestation of Lyell's syndrome, the role of genetic predisposition is not excluded. The presented ob

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5

Chernysh, V. F., N. N. Haritonova, A. N. Kulikov, P. A. Kacherovich, and A. A. Kol'bin. "Current surgical treatment options for ocular complications of Stevens-Johnson and Lyell's syndromes." Russian Journal of Clinical Ophthalmology 23, no. 2 (2023): 99–106. http://dx.doi.org/10.32364/2311-7729-2023-23-2-99-106.

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Epidermolytic drug reactions (EDR) are severe acute drug-induced allergic disorders characterized by extensive lesions of the skin and mucous membranes. Drug-induced Stevens-Johnson and Lyell's syndromes manifested with acute skin and mucous membrane disorders and often leading to lethal outcome may affect eyelids and ocular surface with different levels of severity and thus can cause serious functional ocular complications. The authors present two clinical reports of patients with ocular EDR manifestations in acute and long-term time periods and review the currently available effective treatm

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6

Lobao, B., C. Martins, M. Sousa, S. Marques, and E. Pedroso. "Phenytoin-induced Lyell's syndrome." Case Reports 2012, dec09 1 (2012): bcr2012007746. http://dx.doi.org/10.1136/bcr-2012-007746.

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7

Sehgal, Virendra N., and Govind Srivastava. "Toxic epidermal necrolysis (TEN) Lyell's syndrome." Journal of Dermatological Treatment 16, no. 5-6 (2005): 278–86. http://dx.doi.org/10.1080/09546630500375684.

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8

Zoltie, N., P. Verlende, T. J. O'Neill, and A. W. McKenzie. "Lyell's syndrome on a burns unit." Burns 20, no. 4 (1994): 368–70. http://dx.doi.org/10.1016/0305-4179(94)90072-8.

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9

Turdalieva, B. "Features of the clinical course and risk factors for the development of Lyell's syndrome in children in the Kyrgyz Republic." Bulletin of Science and Practice, no. 12 (December 12, 2017): 214–20. https://doi.org/10.5281/zenodo.1112403.

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Анотація:

The article presents the results of examination of children with a clinical diagnosis of Lyell’s syndrome for patients in the hospital, which allowed us to obtain information on the presence of allergic make when you start acute allergic urticaria and in this specific case it is the terrible complications of the Lyell’s syndrome. As well as the connection with the beginning of illness — premorbid background: genetic, family relationship and predisposing factors in the development of the disease. The connection in the clinical course of the disease with ENT–pathology and

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10

Surov, Aleksandr V., and Ekaterina A. Kalizhnikova. "Ophthalmological manifestations of Lyell's syndrome (clinical case)." Clinical review for general practice 4, no. 7 (2023): 59–63. http://dx.doi.org/10.47407/kr2023.4.7.00287.

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11

Zimmermann, T., W. Schubert, S. Albrecht, et al. "Lyell's syndrome: treatment with Centoxin and selenium." Pediatric Surgery International 9, no. 4 (1994): 297–300. http://dx.doi.org/10.1007/bf00832264.

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12

Schneider, H. G., Margret Kaeding-Smitmanns, and H. Vogel. "Finale Candidasepticopyaemie bei Lyell-Syndrom: Premortal Candida Septicaemia Associated with Lyell's Syndrome*." Mycoses 24, no. 6 (2009): 349–53. http://dx.doi.org/10.1111/j.1439-0507.1981.tb01877.x.

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13

Okhotnikova, O. M., T. M. Tkachоva 0000-0001-8951-7767, A. S. Andriyko, and I. O. Kurian. "Long-term consequences of Lyell's syndrome suffered in childhood." Modern pediatrics. Ukraine, no. 3(115) (April 27, 2021): 69–78. http://dx.doi.org/10.15574/sp.2021.115.69.

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Анотація:

The article provides a review of literature on the long-term consequences of Lyell's syndrome (one of the forms of toxic epidermal necrolysis). Among them: chronic eczema with xerosis and itching, skin depigmentation, hypertrophic and keloid scars, nail lesions, eyes, including dry eye syndrome and chronic conjunctivitis with/without obliteration of the nasolacrimal canal, kidney disease, lung disease, Sjogren's syndrome, Hashimoto's thyroiditis and others. Clinical case. The authors present their clinical case of an 11-year-old girl who suffered from Lyell's syndrome at the age of 8 and has b

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14

Melandri, D. "Lyell's syndrome skin lesions treated by Veloderm®." Journal of the European Academy of Dermatology and Venereology 21, no. 3 (2006): 426–27. http://dx.doi.org/10.1111/j.1468-3083.2006.01919.x.

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15

Ufimtseva, M. A., M. A. Zakharov, O. Yu Averyanov, O. V. Kozhevnikova, N. V. Savchenko, and A. B. Sabino Pereira. "TOXIC EPIDERMOLYSIS CAUSED BY ANTIEPILEPTIC DRUGS: CLINICAL OBSERVATIONS." Pediatria. Journal named after G.N. Speransky 100, no. 1 (2021): 282–87. http://dx.doi.org/10.24110/0031-403x-2021-100-1-282-287.

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Анотація:

Toxic epidermal necrolysis (Lyell's syndrome) and Stevens–Johnson syndrome are severe types of toxicodermia and require emergency medical care. The pathophysiology of toxicoderma is associated with an adverse drug reaction. The article provides data from Russian and international literature on the role of antiepileptic drugs in these diseases occurrence. It also presents clinical cases of toxic epidermal necrolysis in children caused by anticonvulsants intake.

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16

Sadi, Al Muktafi, Takayoshi Toda, Masaya Kiyuna, Tooru Tamamoto, Kazuiku Ohshiro, and Rimi Shinzato. "An Autopsy Case of Malignant Lymphoma with Lyell's Syndrome." Journal of Dermatology 22, no. 8 (1995): 594–99. http://dx.doi.org/10.1111/j.1346-8138.1995.tb03881.x.

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17

Rao Venkata Mahipathy, Surya Rao, Alagar Raja Durairaj, Narayanamurthy Sundaramurthy, Manimaran Ramachandran, and Praveen Ganesh Natarajan. "Lyell’s syndrome: a rare case report." International Surgery Journal 6, no. 4 (2019): 1411. http://dx.doi.org/10.18203/2349-2902.isj20191290.

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Анотація:

Lyell's syndrome or toxic epidermal necrolysis (TEN) is an epidermal detachment of more than 30% of total body surface area, most commonly due an idiosyncratic immune-allergic reaction to a drug. It causes an acute necrosis of the epidermis, with a clinical picture resembling extensive burns. There is also associated mucosal damage and can occasionally develop into a multiorgan having a poor prognosis. Here we report a case of toxic epidermal necrolysis, due to allopurinol intake and its management as in a large burns and stressing the importance of early treatment in an intensive care unit, w

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18

Nunes, JoanaMiranda, Sofia Santareno, Lina Guerreiro, and AnaFilipa Margalho. "Lyell's syndrome and antimalarials: A case report and clinical review." Journal of Global Infectious Diseases 9, no. 1 (2017): 23. http://dx.doi.org/10.4103/0974-777x.199994.

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19

Alemanova, G. D., L. Yu Popova, O. V. Kirichenko, and E. I. Pogrebnova. "Clinical case of toxic epidermal necrolysis (Lyell's syndrome) in pediatric practice." Siberian Journal of Clinical and Experimental Medicine 40, no. 2 (2025): 176–82. https://doi.org/10.29001/2073-8552-2025-40-2-176-182.

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Анотація:

A clinical case of toxic epidermal necrolysis (TEN) in a pediatric patient is presented as a severe pathological process occurring with widespread skin lesions and erosive lesions of the mucous membranes. TEN develops more often as an allergic reaction in response to drugs, the triggers maybe pathogens of infectious diseases. A drug-induced disease may occur in the practice of a pediatrician. To improve the prognosis, timely diagnosis and the use of an individual treatment protocol are important. The presented clinical case confirms the importance of timely diagnosis and early initiation of in

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20

Prazuck, Thierry, Alain Fisch, François Simonnet, and Grégoire Noat. "Lyell's Syndrome Associated with Rifampicin Therapy of Tuberculosis in an AIDS Patient." Scandinavian Journal of Infectious Diseases 22, no. 5 (1990): 629. http://dx.doi.org/10.3109/00365549009027111.

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21

Guillaume, J. C. "The culprit drugs in 87 cases of toxic epidermal necrolysis (Lyell's syndrome)." Archives of Dermatology 123, no. 9 (1987): 1166–70. http://dx.doi.org/10.1001/archderm.123.9.1166.

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22

Guillaume, Jean-Claude. "The Culprit Drugs in 87 Cases of Toxic Epidermal Necrolysis (Lyell's Syndrome)." Archives of Dermatology 123, no. 9 (1987): 1166. http://dx.doi.org/10.1001/archderm.1987.01660330077013.

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23

Fouzia HALI, Anass ABBOUR, Ahlam MEFTAH, and Soumiya CHIHEB. "Paracetamol-induced Lyell syndrome in a 3-year-old child: A case report and review of the literature." International Journal of Science and Research Archive 15, no. 3 (2025): 1205–8. https://doi.org/10.30574/ijsra.2025.15.3.1868.

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Анотація:

Lyell's syndrome (LS), also known as toxic epidermal necrolysis (TEN), is a rare but severe drug-induced mucocutaneous eruption that can be fatal. Although it is a well-known condition in adults, its incidence in children is considerably lower. Among the drugs associated with LS, paracetamol (acetaminophen) is infrequently implicated. We present the case of a 3-year-old male who developed LS following paracetamol administration. This case highlights the importance of early recognition, prompt treatment, and the need for heightened awareness regarding the potential for severe adverse reactions

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24

Samudrala, Lahari, Bhanu Pratap Singh, Rajya Laxmi Papasani, Tharun Bashaboina, and Ramarao Tadikonda. "Non-steroidal anti-inflammatory drugs induced toxic epidermal necrolysis." International Journal Of Community Medicine And Public Health 12, no. 4 (2025): 1900–1903. https://doi.org/10.18203/2394-6040.ijcmph20250944.

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Анотація:

This case report presents a 48-year-old woman with a history of chronic kidney disease who experienced toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, an uncommon and severe adverse drug reaction. The TEN was attributed to the use of non-steroidal anti-inflammatory drugs (NSAIDs). Cutaneous involvement exceeded 80% of the body surface area (BSA), encompassing ocular, oral, and nasal mucosa, as well as the trunk, bilateral limbs, and genitalia. Treatment commenced with aggressive fluid resuscitation, the administration of cyclosporine, and meticulous dermal care. The patient w

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25

Paquet, P., E. Jacob, and G. E. Pierard. "Cystic lesion of the parotid following drug-induced toxic epidermal necrolysis (Lyell's syndrome)." Journal of Oral Pathology and Medicine 34, no. 6 (2005): 380–82. http://dx.doi.org/10.1111/j.1600-0714.2005.00315.x.

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26

Luderschmidt, Chr, O. Linderkamp, and J. Ring. "Drug-induced toxic epidermal necrolysis (Lyell's syndrome) in a 4-year-old girl." European Journal of Pediatrics 144, no. 1 (1985): 91–93. http://dx.doi.org/10.1007/bf00491939.

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27

Paquet, P., E. Jacob, P. Damas, and G. E. Piérard. "Treatment of drug-induced toxic epidermal necrolysis (Lyell's syndrome) with intravenous human immunoglobulins." Burns 27, no. 6 (2001): 652–55. http://dx.doi.org/10.1016/s0305-4179(01)00005-5.

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28

RING, J., D. VIELUF, G. WIMSCHNEIDER, and B. PRZYBILLA. "347 Drug-induced Lyell's syndrome (Toxic epidermal necrolysis): An analysis of 24 cases." Journal of Allergy and Clinical Immunology 87, no. 1 (1991): 226. http://dx.doi.org/10.1016/0091-6749(91)91630-c.

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29

Tukhvatshina, I. A., R. Y. Ziyazetdinova, L. N. Ismagilova, O. I. Orenburkina, and T. I. Bikkuzin. "Keratoprostheses in present ophthalmology." POINT OF VIEW. EAST – WEST, no. 3 (October 27, 2023): 45–49. http://dx.doi.org/10.25276/2410-1257-2023-3-45-49.

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Анотація:

The shortage of donor corneas for keratoplasty in patients with severe disorders (persistent opacity, corneal leucoma of IV–V categories, including leucoma with vascularization, after burns, multiple transplant failures, with extensive symblepharon, Stevens – Johnson syndrome, Lyell's syndrome, ocular cicatricial pemphigoid, etc) is currently compensated by keratoprostheses, which partly or completely consist of synthetic materials, show good engraftment and high vision restoration efficacy. The article is a review of main scientific papers on keratoprostheses. The authors state characteristic

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30

Al-Adhal, Adnan, Abdulhakeem Al-Absi, Noha Zewar, Amr Al-Adhal, and Abdalla Al-Adhal. "Toxic Epidermal Necrolysis: A Case Report in Azal hospital, Sana'a, Yemen." Arab Journal for Scientific Publishing 7, no. 64 (2024): 545–52. http://dx.doi.org/10.36571/ajsp6424.

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Toxic epidermal necrosis (TEN) is a life-threatening connective tissue disorder also known as Lyell's syndrome, characterized by erythema, and epidermal detachment, manifests as blisters, and raw skin patches. Adverse drug reactions are the most common risk factors. TEN is identical with Steven-Johnson's syndrome (SJS), differs from the latter in that greater area of the skin is involved. In this article, we report a case of a 20 years old male patient who presented with complaints of lethargy, red eyes and blisters after prescription of carbamazepine. Following this, the drug was taken off im

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31

Korzeniowski, Tomasz, Jerzy Strużyna, Ryszard Mądry, et al. "Lyell's syndrome complicated by staphylococcus aureus sepsis and multiple organ dysfunction – a case report." Chirurgia Plastyczna i Oparzenia / Plastic Surgery & Burns 2, no. 1 (2014): 23–26. http://dx.doi.org/10.15374/chpio20140014.

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32

Saginala Dharani. "A Case report on Toxic Epidermal Necrolysis." International Journal of Allied Medical Sciences and Clinical Research 12, no. 1 (2024): 1–3. http://dx.doi.org/10.61096/ijamscr.v12.iss1.2024.1-3.

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Анотація:

Toxic epidermal necrolysis (TEN) is a group of severe forms of several life-threatening conditions. As a co-infection of this group, Stevens-Johnson syndrome (SJS) is a rare though severe disease of the skin and mucous membranes. Intake of some drugs could cause reactions such as SJS and TEN. A form of severe connective tissue disorder, TEN is also known as Lyell's syndrome and is a common cause of significant skin and mucous membrane disintegration in the majority of cases, the administration of pharmaceutical drugs is thought to be the primary cause of SJS/TEN. In this article, we report a c

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33

Arellano, Félix, and José A. Sacristán. "Allopurinol Hypersensitivity Syndrome: A Review." Annals of Pharmacotherapy 27, no. 3 (1993): 337–43. http://dx.doi.org/10.1177/106002809302700317.

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OBJECTIVE: To review the pathophysiology, pathology, and clinical findings of allopurinol hypersensitivity syndrome (AHS), an infrequent but life-threatening adverse effect of allopurinol therapy. DATA SOURCES: A MEDLINE search (key terms hepatitis, interstitial nephritis, severe hypersensitivity, severe toxicity, vasculitis, toxic epidermal necrolysis, Lyell's syndrome, erythema multiforme, and Stevens-Johnson syndrome) was used to identify cases reported in the literature through the end of 1990. STUDY SELECTION: All cases evaluated met Singer and Wallace's diagnostic criteria for AHS. DATA

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34

Babushkin, A. E., and G. Z. Israfilova. "Rare clinical cases of lesions of the ocular surface of various etiologies." Modern technologies in ophtalmology, no. 3 (June 1, 2023): 183–90. http://dx.doi.org/10.25276/2312-4911-2023-3-183-190.

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Анотація:

The article presents several rare cases from clinical practice. In particular, they concern conjunctivitis, which was the first sign of COVID 19 infection, corneotoxic corneal lesions in the form of an extensive ulcer due to the abuse of local anesthetic oxybuprocaine. Other clinical cases of ocular surface damage are associated with vaccination against a new coronavirus infection, namely with the development of adenoviral keratoconjunctivitis after LASIK refractive intervention and subsequent early (after 5 days) immunoprophylaxis with the Gam-COVID-Vac vaccine, as well as with such a rare al

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35

Kadyrov, R. Z., R. E. Primov, and I. R. Karachurina. "Clinical case of Alloplant biomaterial use in surgical treatment of ophthalmological complications in patient with Lyell's syndrome." Practical medicine 17, no. 1 (2019): 141–44. http://dx.doi.org/10.32000/2072-1757-2019-1-141-144.

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36

Chanques, G., C. Girard, V. Pinzani, and S. Jaber. "Fatal pristinamycin-induced toxic epidermal necrolysis (Lyell's syndrome): difficulties in attributing causal association in the polymedicated intensive care unit patient." Acta Anaesthesiologica Scandinavica 49, no. 5 (2005): 721–22. http://dx.doi.org/10.1111/j.1399-6576.2005.00685.x.

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37

Armakov, Sergey Petrovich. "Forms of drug allergy and various variants of its manifestation." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 9 (July 12, 2021): 43–48. http://dx.doi.org/10.33920/med-10-2109-04.

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Анотація:

Lately, the problem of drug allergy is becoming more and more urgent, which is a consequence of the wide availability of drugs and the widespread use of counterfeit drugs. According to some authors, the incidence of drug allergy reaches 60%. This pathological reaction is the result of the patient's individual intolerance to one or another medication, and is not inherently its side effect. In some cases, the ingestion of a minimum dose of a drug into the body is sufficient for a severe reaction to develop. Theoretically, any drug can cause an allergy, but there is a group of certain medications

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38

Mochulska, O. M., and T. M. Kosovska. "Systemic therapy of allergic dermatosis in children (literature review)." Modern pediatrics. Ukraine, no. 1(113) (February 19, 2021): 62–67. http://dx.doi.org/10.15574/sp.2021.113.62.

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Анотація:

Allergic pathology of skin is one of the most pressing problems of modern pediatry. The most common allergic dermatoses: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome). Many aspects of systemic treatment of allergic dermatoses in children are complex and controversial. The modern strategy of treatment of allergic dermatoses in children is based on the principles of evidence-based medici

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39

FC, Loembe, Mintsa EL, Mekame A E, Midili T L, Minto’o R.S, and Nzame.Y. "Clinical, Therapeutic, and Evolutionary Aspects of Stevens-Johnson Syndrome and Lyell's Syndrome in the Pediatric Department of the University Hospital Center of Libreville: Report of Two Clinical Cases." Asian Journal of Pediatric Research 15, no. 1 (2025): 9–15. https://doi.org/10.9734/ajpr/2025/v15i1417.

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Анотація:

Objective: The objective of this study is to report two pediatric cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), highlighting the clinical, therapeutic, and evolutionary aspects of these conditions. Study Design: This is a case study conducted at the University Hospital Center of Libreville in Gabon, involving two children aged 3 and 5 years, diagnosed with SJS and TEN, respectively. The cases were observed and followed over several weeks, with the collection of clinical, biological, and evolutionary data for each patient. Methodology: Both children developed sym

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40

Skrypnykova, T. P., P. M. Skrypnykov, T. A. Khmil, et al. "CLINICAL PROFILES OF PATIENTS WITH MULTIFORM EXUDATIVE ERYTHEMA AND STEVENS-JOHNSON SYNDROME IN DENTAL PRACTICE." Ukrainian Dental Almanac, no. 1 (March 28, 2025): 18–21. https://doi.org/10.31718/2409-0255.1.2025.03.

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Анотація:

The diagnosis and treatment of erythema multiforme (EM) and Stevens-Johnson syndrome (SJS) is still a difficult issue in the practice of dentists. It is important for dentists to have a clear understanding of these diseases to provide appropriate care for patients. Materials and methods. The aim of the study was to investigate the prevalence, clinical features, diagnosis, and treatment of EM and SJS at an outpatient dental visit. The work was performed based on the analysis of data from the Regional Scientific and Practical Center for Oral Mucosa Diseases, which operates at the Department of P

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Mochulska, O. M., and K. T. Hlushko. "Peculiarities of the clinical course of allergic dermatoses in children (literature review)." Modern pediatrics. Ukraine, no. 7(111) (November 29, 2020): 58–63. http://dx.doi.org/10.15574/sp.2020.111.58.

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The prevalence of allergic diseases is constantly growing around the world. According to WHO forecasts, most of the world's population will suffer from various allergies by 2050, at the same time any substance can be an allergen, and the XXI century will be the era of allergies. In the structure of allergic diseases in children the leading place is occupied by allergic skin lesions — allergic dermatoses, which are characterized by pronounced clinical polymorphism, acute or chronic stage with the development of concomitant pathological changes in many systems of the growing child's body. Allerg

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Mochulska, O. M. "External therapy of allergic dermatoses in children (literature review)." UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS, no. 4(84) (December 30, 2020): 41–47. http://dx.doi.org/10.15574/pp.2020.84.41.

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Allergic dermatoses have a special place in the structure of allergic diseases in children due to their weight. The most common allergic skin lesions: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, multiforme exudative erythema (Stevens—Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome), toxicodermias, as well as less common dermatoses, in the pathogenesis of which are leading allergic reactions. Despite a number of research research, the difficulties in the determining of the therapeutic

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Mochulska, O. M. "Features of pathogenesis of itch and anti0itch therapy in children with allergic dermatosis (literature review)." Ukrainian journal of Perinatology and Pediatrics, no. 2(86) (June 25, 2021): 57–67. http://dx.doi.org/10.15574/pp.2021.86.57.

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Allergic dermatoses are allergic skin diseases, the most common of which are: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens–Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome). The clinical course of all allergic dermatoses is accompanied by itch, although its severity varies depending on the nosology. An important focus of treatment of allergic dermatoses is to control of skin itch, as it is the leading symptom. According to the intern

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P, Ramu, and Annapurna D. "TOXIC EPIDERMAL NECROLYSIS ( TEN / LYELL'S SYNDROME) IS A SERIOUS AND RAPIDLY PROGRESSIVE FATAL ERUPTION OF SKIN FOLLOWING CARBAMAZEPINE INTAKE, NEEDS PROMPT ADMISSION AND URGENT CARE." Journal of Evolution of Medical and Dental Sciences 04, no. 10 (2015): 1718–22. http://dx.doi.org/10.14260/jemds/2015/245.

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Escuredo, Iker Miguel, Laura Cabañas Weisz, Javier Vásquez Manau, Juan Bautista Ayestarán Soto, and Jesus Gardeazabal García. "Toxic epidermal necrolysis: management strategies in burns units." Journal of Wound Care 33, no. 12 (2024): 942–49. https://doi.org/10.12968/jowc.2021.0063.

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Objective: The most common severe exfoliative condition is toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, for which patients may sometimes require admission to hospital burns units. This study analyses the experience of the authors and results in this condition at the Cruces University Hospital in Bilbao, Spain. Method: Over the last 22 years, the authors carried out a retrospective analytical observational study of TEN cases at the hospital and analysed risk factors including age, associated comorbidities, percentage of body surface area affected, positive bacterial culture

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Coussirou, Julie, Magali Ravoire, Alma Stancu, and Léa Vazquez. "Anti-Cancer Drug-Induced Lyell’s Syndrome: A Series of Two Patients." Current Oncology 31, no. 11 (2024): 6891–97. http://dx.doi.org/10.3390/curroncol31110509.

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Lyell’s syndrome or Toxic Epidermal Necrolysis (TEN) is a rare and life-threatening dermatological disease. Most commonly, this syndrome is drug-induced, and is a result of an immune-allergic reaction to medications. Anti-cancer drugs were not the most frequent groups of therapeutic agents related to Lyell’s syndrome, but the emergence of new therapeutic classes, particularly targeted therapy and immunotherapy, is changing current data. We present two cases of Lyell’s syndrome induced by anticancer drugs. (1) TEN in a man treated for metastatic urothelial carcinoma with Enfortumab Vedotin. (2)

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Krivosheev, Alexandr B., Tamara V. Ermachenko, Pavel P. Khavin, Inga A. Krivosheeva, and Dmitry V. Morozov. "Lyell´s syndrome provoked by external drug use." Russian Journal of Skin and Venereal Diseases 24, no. 1 (2021): 25–34. http://dx.doi.org/10.17816/dv62377.

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Lyells syndrome is rare. Up to 10 cases are registered per million population per year. The mortality rate for Lyells syndrome is 512%. Two patients were observed aged, respectively, 38 years and 72 years with Lyells syndrome. The disease manifested itself against the background of local application of drugs. In one case ― Dolobens gel as an analgesic at the site of a bruise of the right hand. In another case, a 20% solution of chlorohxidin biogluconate as a mouth rinse for stomatitis. The first symptoms of the disease occurred locally at the site of application of these medicines. In th

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Kolomiiets, S. V., O. V. Hurzhii, and V. I. Shynkevych. "DENTAL CARE LEVEL ASSESSMENT AT SDS/TEN: SYSTEMATIC ANALYSIS OF CLINICAL CASES." Ukrainian Dental Almanac, no. 3 (September 6, 2019): 21–26. http://dx.doi.org/10.31718/2409-0255.3.2019.04.

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Background. Dental care is essential for all hospitalized patients with Stevens-Johnson syndrome and/or toxic epidermal necrolysis (SJS/TEN), the clinical cases of which are reported annually in scientific journals. Purpose of publication was analysis of dental care from clinical reports about SJS/TEN and ours own clinical case of SJS, for dental help optimization. Materials and methods. The clinical cases reports in Russian and Ukrainian languages of databases Google and Google Academy from 2016 to May 2019 (and some earlier publications) were selected by the keywords "Stevens-Joh

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Mądry, Ryszard, and Jerzy Strużyna. "Zastosowanie opatrunków srebrowych w leczeniu oparzeń i odmrożeń, zespołu Lyella oraz ran przewlekłych." Chirurgia Plastyczna i Oparzenia / Plastic Surgery & Burns 8, no. 4 (2020): 115–22. http://dx.doi.org/10.15374/chpio2020013.

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The skin is the largest organ of the human body and is composed of several layers each having different properties and physiological functions. The loss of skin integrity due to injury or disease can lead to acute physiological and immune disorders which may even result in death. The following properties are taken into consideration when choosing an appropriate dressing for the burn wound: the ability to support epithelialization and granulation, reduction of pain, patient discomfort, and costs. The aim of this study is to evaluate the usefulness of silver dressings in treatment of burns, fros

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Channabasappa, Shivakumar M., Bhavna Gupta, and Shruthi Dharmappa. "Vajra Bhasma, Ayurvedic medicine: a rare and unusual cause of Lyell’s syndrome and its successful management." BMJ Case Reports 13, no. 10 (2020): e237891. http://dx.doi.org/10.1136/bcr-2020-237891.

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Toxic epidermolysis necrosis (TEN) or Lyell syndrome is a potentially life-threatening immunological adverse skin disease, which mostly occurs secondary to the intake of an offending drug. It commonly manifests as a widespread exfoliating bullous lesion in skin and mucous membrane mimicking superficial burns and may result in hypovolemic and/or septic shock. Authors report an unusual case of Lyell’s syndrome in a 42-year-old woman, secondary to the intake of Ayurveda medicine ‘Vajra Bhasma’ (Diamond Ash) prescribed by an Ayurveda physician for treatment of her trigeminal neuralgia. After 8th d

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