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Готові списки джерел за темами / Lymphocytes Immunological aspects / Статті в журналах

Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: Lymphocytes Immunological aspects.

Статті в журналах з теми "Lymphocytes Immunological aspects"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 28 січня 2023

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1

Teplen’kiy, M. P., M. V. Chepeleva, and E. I. Kuznetsova. "PERTHES DISEASE: IMMUNOLOGICAL ASPECTS." Russian Clinical Laboratory Diagnostics 65, no. 4 (April 15, 2020): 239–43. http://dx.doi.org/10.18821/0869-2084-2020-65-4-239-243.

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Considering a stage of the pathological process patients (boys at the age of 8-12 years) were divided into two (2) groups. Group I included 14 patients with the fragmentation stage (Perthes disease Stage II). Group 2 included 15 children with Perthes disease Stage III (the stage of re-ossification). Perthes disease regardless of the stage of the disease was characterized by the increase in oxygen-dependent and lysosomal phagocytic activity of neutrophils, the increase in the number of early extracellular traps, as well as by increased concentrations of pro-inflammatory cytokines (IL-1β and TNF

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2

Kölsch, E. "T supressor lymphocytes aspects of immunological tolerance." Research in Immunology 140, no. 3 (January 1989): 286–90. http://dx.doi.org/10.1016/0923-2494(89)90063-1.

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3

Veretennikov, S. V., V. V. Trusov, A. A. Dmitriev, and V. S. Suskova. "Immunological aspects of long-term insulin-dependent diabetes mellitus." Kazan medical journal 72, no. 1 (January 15, 1991): 30–32. http://dx.doi.org/10.17816/kazmj96326.

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The results of a comprehensive study of immune homeostasis in 45 patients with long-term insulin-dependent diabetes mellitus are presented. In 50% of the examined patients, the absolute number of leukocytes was reduced, in a third - the number of lymphocytes and the total population of T-lymphocytes, in every second patient - the number of T-helpers and in a quarter - T-suppressors, and quite significantly. In 50% of patients, a sharp decrease in the immunoregulatory index, a significant decrease in the absolute number of B-lymphocytes were found. A significant increase in the content of activ

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4

Timasheva, Ya R. "IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION." Medical Immunology (Russia) 21, no. 3 (July 13, 2019): 407–18. http://dx.doi.org/10.15789/1563-0625-2019-3-407-418.

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According to modern concept of the etiopathogenesis of essential hypertension, immune cells play an important role in its development. Mediators produced by immunocompetent cells participate in the initiation and maintenance of chronic systemic inflammation and promote the development of vascular remodeling which is an important part of the pathogenesis of the disease and target organ damage. The immune mechanisms underlying blood pressure elevation include the activation of innate and adaptive immune cells. Endothelial damage triggers an inflammatory cascade, causing migration of the immune c

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5

Vantiukh, N. V., O. I. Lemko, and D. V. Reshetar. "Chronic Bronchial Obstruction and Endothelial Dysfunction: Some Immunological Aspects of Interaction." Asthma and allergy 2022, no. 3 (2022): 14–21. http://dx.doi.org/10.31655/2307-3373-2022-3-14-21.

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Abstract. According to modern data, systemic inflammatory process with vascular endothelial dysfunction (ED) is the base of chronic obstructive pulmonary disease (COPD) pathogenesis whith chronic bronchial obstruction and the formation of comorbidity. Immunological investigations of relationship with severity of ED and risk of fatal cardiovascular events remain actual at COPD, although many studies of their dependence on the severity of COPD have been conducted. The aim of the study is to evaluate the special features of cellular immunity in patients with COPD in relation to the severity of cl

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6

Kokron, Cristina M., Paolo R. Errante, Myrthes T. Barros, Gisele V. Baracho, Maristela M. Camargo, Jorge Kalil, and Luiz V. Rizzo. "Clinical and laboratory aspects of common variable immunodeficiency." Anais da Academia Brasileira de Ciências 76, no. 4 (December 2004): 707–26. http://dx.doi.org/10.1590/s0001-37652004000400007.

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Common variable immunodeficiency (CVID) is an immunological disorder characterized by defective antibody production, recurrent infections, most notably of the respiratory tract, autoimmune phenomena and cancer. Some CVID patients may also present disturbances of the cellular immune response such as a decrease in the number and proportion of different lymphocyte populations, diminished lymphoproliferative response to mitogens and antigens, altered production of cytokines, and deficient expression of cell-surface molecules. Most Brazilian CVID patients included in this study show a decrease in T

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7

NOVIKOVA, I. A., A. V. GOMOLYAKO, and M. V. ZLOTNIKOVA. "Clinical and immunological aspects of recurrent, bacterial and viral skin affections." Vestnik dermatologii i venerologii 87, no. 2 (April 15, 2011): 44–48. http://dx.doi.org/10.25208/vdv993.

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The authors analyzed the subpopulation composition of lymphocytes in the peripheral blood of 69 patients suffering from chronic recurrent furunculosis and herpes at the stage of remission. They revealed similar changes in the form of an increased content of T-helpers and immunoregulatory index. In herpes patients such changes are accompanied with the reduced number of natural killers while in furunculosis patients changes are related to the reduced amount of activated T-lymphocytes. These changes do not depend on the relapse duration or frequency but are related to the number of exacerbations

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8

Panaschatenko, A. S., I. A. Panova, A. I. Malyshkina, E. A. Rokotyanskaya, A. V. Kudryashova, N. Yu Sotnikova, L. V. Kulida, and E. V. Protsenko. "IMMUNOLOGICAL AND PATHOMORPHOLOGICAL ASPECTS OF EARLY AND LATE PREECLAMPSIA." Medical Immunology (Russia) 23, no. 4 (October 19, 2021): 845–52. http://dx.doi.org/10.15789/1563-0625-iap-2292.

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Preeclampsia (PE) is one of the most common complications of pregnancy, and it can be after 20 weeks of gestation. It ends only with a complete dissection of afterbirth. Traditionally, PE is subdivided into the early one, taking place through 34 weeks of pregnancy (EOPE) and the late one, which is after 34 weeks of gestation (LOPE). Clinical manifestations are similar in both cases however, risk factors and the severity of PE are different . It has been established that EOPE is determined by impaired trophoblast invasion and transformation of the spiral arteries of the uterus in early pregnanc

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9

Rathi, Monika, Faiyaz Ahmad, Satish Kumar Budania, Seema Awasthi, Ashutosh Kumar, and Shyamoli Dutta. "Cytomorphological Aspects of Hashimoto's Thyroiditis: Our Experience at a Tertiary Center." Clinical Medicine Insights: Pathology 7 (January 2014): CPath.S13580. http://dx.doi.org/10.4137/cpath.s13580.

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Introduction Hashimoto's thyroiditis is the most common form of acquired hypothyroidism. Fine needle aspiration cytology is one important tool in diagnosing Hashimoto's thyroditis, along with clinical, biochemical, immunological and ultrasonographical modalities. The present study examines cytological aspects of Hashimoto's thyroiditis along with their correlation with clinical, biochemical and immunological findings, whenever available. Materials and Methods This is a retrospective study of 50 cases of Hashimoto's thyroiditis. Cytological findings were reviewed and correlated with clinical, b

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10

Kulygina, Elena S., Maxim P. Razin, Sergey B. Petrov, Elena B. Dunaeva, and Victoria A. Makhneva. "The use of tablet form of Polyoxidonium® for immunocorrection in children with secondary pyelonephritis." Pediatrician (St. Petersburg) 12, no. 5 (December 14, 2021): 37–45. http://dx.doi.org/10.17816/ped12537-45.

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Background. Some aspects of diagnostics and treatment of secondary pyelonephritis in children continue to be urgent tasks of pediatrics, especially with regard to immunological changes in this disease and the search for ways to optimally correct them. The purpose of the study: to study immunological disorders in children with VP and to determine the features of the use of the tablet preparation Polyoxidonium for their correction. Materials and methods. The study is an open controlled prospective comparative single-center study, including two groups: observation and control. The observati

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11

Santana, Eliete Souza, Thiago Souza Azeredo Bastos, José Henrique Stringhini, Regiane Nascimento Gagno Porto, Robson Rodrigues Santana, Darling Melany De Carvalho Madrid, and Maria Auxiliadora Andrade. "Salmonella Enteritidis detection and immunological cellular response to experimental inoculation in day-old turkeys." Semina: Ciências Agrárias 39, no. 1 (February 16, 2018): 177. http://dx.doi.org/10.5433/1679-0359.2018v39n1p177.

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The purpose of this research is to clarify aspects of the pathogenesis of Salmonella Enteritidis in experimentally inoculated day-old turkeys. Three treatments were conducted among a total of 120 turkeys; one control group and two treatment groups in which 6 x 102 CFU mL-1 and 7 x 105 CFU mL-1, respectively, of Salmonella Enteritidis was inoculated in the crops. Two birds from each treatment were sacrificed and necropsied at 1, 3, 4, 12, 18, and 24 hours, and 3, 4, 38, and 49 days post-inoculation. We re-isolated Salmonella, measured lymphocytes, and conducted immunohistochemical tests. Six ho

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12

Dekhtiarenko, N. О., L. M. Panchenko, M. P. Hrytsai, O. M. Linenko, V. I. Sabadosh, and K. M. Salmanova. "Analysis of Some Immunological Aspects of Joint Infections Developed as a Result of Intra-Articular Glucocorticoid Injection." Visnyk Ortopedii Travmatologii Protezuvannia, no. 4(111) (December 20, 2021): 21–27. http://dx.doi.org/10.37647/0132-2486-2021-111-4-21-27.

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Summary. The work is devoted to the studies of immune status of patients with infectious complications after local glucocorticoid injections. Objective: to assess the state of the immune system of patients with infectious complications after local glucocorticoid injections, to monitor the dynamics of immunological parameters before and after sanitizing surgical treatment, and to reveal factors that are important for predicting the course of the disease and treatment results. Materials and Methods. The immune status of 26 patients with purulent inflammatory processes after local glu

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13

Cracco, C., S. Biasiol, G. Filogamo, and S. Rocca Rossetti. "Immunological aspects of urethral stenosis. Involvement of the S100 protein-positive dendritic cells." Urologia Journal 62, no. 1_suppl (January 1995): 53–58. http://dx.doi.org/10.1177/039156039506201s12.

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— Within the superficial layers of healthy skin and of some mucosae there is a Population of accessory cells of the immune system, able to interact with T helper lymphocytes. Such cells, called tissular dendritic cells (DCs), increase their density and display different morphological features in a variety of immunologically-mediated dermatological disorders. In the present work we investigated DCs within the various urethral segments, both in normal conditions and in urethral stenosis. The specimens, obtained from urethrectomies and urethroplasties with end-to-end anastomosis, were stained wit

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14

Rabiah, N. A. Al, A. C. O. Evans, J. McCormack, J. A. Browne, P. Lonergan, and T. Fair. "6 Immunological aspects of ovarian follicle ovulation and corpus luteum formation in cattle." Reproduction, Fertility and Development 33, no. 2 (2021): 110. http://dx.doi.org/10.1071/rdv33n2ab6.

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Ovarian follicle ovulation and subsequent luteinization have been described as a controlled inflammatory event, comprising tissue damage and repair. To elaborate this further in cattle, the contribution of immune cells to dominant follicle luteinization, ovulation, and corpus luteum formation was investigated. Ovulation in beef heifers was synchronized using an 8-day progesterone-based synchronization program. Heifers were slaughtered at a local abattoir at 5 timepoints (T): (T1) 24h before ovulation (n=10); (T2) 2h before ovulation (n=9); (T3) 6h after ovulation (n=10); (T4) 24h after ovulati

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15

Rabiah, N. A. Al, A. C. O. Evans, J. McCormack, J. A. Browne, P. Lonergan, and T. Fair. "6 Immunological aspects of ovarian follicle ovulation and corpus luteum formation in cattle." Reproduction, Fertility and Development 33, no. 2 (2021): 110. http://dx.doi.org/10.1071/rdv33n2ab6.

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Ovarian follicle ovulation and subsequent luteinization have been described as a controlled inflammatory event, comprising tissue damage and repair. To elaborate this further in cattle, the contribution of immune cells to dominant follicle luteinization, ovulation, and corpus luteum formation was investigated. Ovulation in beef heifers was synchronized using an 8-day progesterone-based synchronization program. Heifers were slaughtered at a local abattoir at 5 timepoints (T): (T1) 24h before ovulation (n=10); (T2) 2h before ovulation (n=9); (T3) 6h after ovulation (n=10); (T4) 24h after ovulati

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16

Mikhaleva, L. M., M. R. Orazov, E. S. Silantieva, D. P. Kamilova, K. Yu Midiber, and R. E. Orekhov. "Repeated Implant Failures. Pathogenesis of Immunological Disorders in Endometrium." Doctor.Ru 21, no. 1 (2022): 21–26. http://dx.doi.org/10.31550/1727-2378-2022-21-1-21-26.

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Study Objective: To broaden the understanding of the immunological aspects of implantation incompetence of endometrium in patients with repeated implant failures (RIF) in in vitro fertilisation programs. Study Design: Open perspective comparative study. Materials and Methods. 57 women aged 27 to 42 years old (mean age: 36 ± 6.2 years old) with clinically verified RIF. A morphological control group included 30 fertile women with a history of at least 2 deliveries of full-term healthy children and without fertility disorders, who signed a voluntary informed consent to take part in the study. The

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17

Konkova-Reidman, Alyona Borisovna, A. A. Veksei, N. V. Smirnova, and O. A. Pischulova. "CLINICAL-EPIDEMIOLOGICAL CHARACTERISTIC OF AIDS-ASSOCIATED CRYPTOCOCCOSIS: DIAGNOSTICS AND THERAPEUTIC ASPECTS OF THE PROBLEM." Epidemiology and Infectious Diseases (Russian Journal) 23, no. 4 (August 15, 2018): 156–64. http://dx.doi.org/10.18821/1560-9529-2018-23-4-156-164.

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Introduction Currently, cryptococcosis is among the three most life-threatening opportunistic infections in AIDS patients. Materials and methods. The analysis of cases of cryptococcosis in HIV-infected patients in the world, the Russian Federation and the Chelyabinsk region using the methods of descriptive and analytical epidemiology. Two clinical cases of verified cryptococcosis were analyzed in detail in patients in the phase of HIV infection progression in the absence of antiretroviral therapy. Results. The manifestation of the disease was observed in the phase of progression of HIV infecti

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18

Konkova-Reidman, Alyona Borisovna, A. A. Veksei, N. V. Smirnova, and O. A. Pischulova. "CLINICAL-EPIDEMIOLOGICAL CHARACTERISTIC OF AIDS-ASSOCIATED CRYPTOCOCCOSIS: DIAGNOSTICS AND THERAPEUTIC ASPECTS OF THE PROBLEM." Epidemiology and Infectious Diseases (Russian Journal) 23, no. 4 (August 15, 2018): 156–64. http://dx.doi.org/10.18821/1560-9529-2019-23-4-156-164.

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Introduction Currently, cryptococcosis is among the three most life-threatening opportunistic infections in AIDS patients. Materials and methods. The analysis of cases of cryptococcosis in HIV-infected patients in the world, the Russian Federation and the Chelyabinsk region using the methods of descriptive and analytical epidemiology. Two clinical cases of verified cryptococcosis were analyzed in detail in patients in the phase of HIV infection progression in the absence of antiretroviral therapy. Results. The manifestation of the disease was observed in the phase of progression of HIV infecti

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19

Pereira, Leonn Mendes Soares, Eliane dos Santos França, Iran Barros Costa, Igor Tenório Lima, Amaury Bentes Cunha Freire, Francisco Lúzio de Paula Ramos, Talita Antonia Furtado Monteiro, et al. "Epstein–Barr Virus (EBV) Genotypes Associated with the Immunopathological Profile of People Living with HIV-1: Immunological Aspects of Primary EBV Infection." Viruses 14, no. 2 (January 18, 2022): 168. http://dx.doi.org/10.3390/v14020168.

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Background: The aim of the present study was to evaluate the immunological profile of adult HIV-1+ patients coinfected with primary Epstein–Barr virus (EBV) infection who were free of antiretroviral drugs and inhabitants of the Brazilian Amazon region. Materials and methods: Primary EBV infection was screened by the semiquantitative detection of IgM and IgG anti-VCA. Genotypes were determined by conventional PCR. EBV and HIV viral load (VL) were quantified by real-time PCR. Cytokine dosage and cell quantification were performed by cytometry. Results: Only HIV-1+ individuals had primary EBV inf

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20

Signorile, Anna, Anna Ferretta, Maddalena Ruggieri, Damiano Paolicelli, Paolo Lattanzio, Maria Trojano, and Domenico De Rasmo. "Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics." Antioxidants 10, no. 1 (December 28, 2020): 21. http://dx.doi.org/10.3390/antiox10010021.

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Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative chronic disease that involves the immune and central nervous systems (CNS). The pathogenesis involves the loss of blood–brain barrier integrity, resulting in the invasion of lymphocytes into the CNS with consequent tissue damage. The MS etiology is probably a combination of immunological, genetic, and environmental factors. It has been proposed that T lymphocytes have a main role in the onset and propagation of MS, leading to the inflammation of white matter and myelin sheath destruction. Cyclic AMP (cAMP), mitochondrial d

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21

Rallabhandi, Prasad. "Gluten and Celiac Disease—An Immunological Perspective." Journal of AOAC INTERNATIONAL 95, no. 2 (March 1, 2012): 349–55. http://dx.doi.org/10.5740/jaoacint.sge_rallabhandi.

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Abstract Gluten, a complex protein group in wheat, rye, and barley, causes celiac disease (CD), an autoimmune enteropathy of the small intestine, in genetically susceptible individuals. CD affects about 1% of the general population and causes significant health problems. Adverse inflammatory reactions to gluten are mediated by inappropriate T-cell activation leading to severe damage of the gastrointestinal mucosa, causing atrophy of absorptive surface villi. Gluten peptides bind to the chemokine receptor, CXCR3, and induce release of zonulin, which mediates tight-junction disassembly and subse

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22

Vitetta, Luis, Jiezhong Chen, and Stephen Clarke. "The vermiform appendix: an immunological organ sustaining a microbiome inoculum." Clinical Science 133, no. 1 (January 2019): 1–8. http://dx.doi.org/10.1042/cs20180956.

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AbstractThe hominoid vermiform appendix has been characterized as a diverticulum of the caecum and describes an entity at the juxtaposition of the colon in the confluence of tanias. The independent development of the lymphoid follicle centres of the appendix is progressed at birth in the presence of the intestinal commensal microbiome, an obligatory prompt for the diversification of intestinal and extra-intestinal mucosal immunological tissue. In the vermiform appendix, this activity is centred on further developing the inventory of primary antibodies and the maturation of T- and B-lymphocyte

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23

Sobstyl, Małgorzata, Paulina Niedźwiedzka-Rystwej, Ewelina Grywalska, Izabela Korona-Głowniak, Anna Sobstyl, Wiesława Bednarek, and Jacek Roliński. "Toll-Like Receptor 2 Expression as a New Hallmark of Advanced Endometriosis." Cells 9, no. 8 (July 30, 2020): 1813. http://dx.doi.org/10.3390/cells9081813.

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Recent evidence suggests that immunological aspects play a pivotal role in this disorder. Toll-like receptor 2 (TLR2) is crucial in recognizing microbial infections and mediating innate immune response. The objective of our study was to rate with flow cytometry the levels of several subsets of dendritic cells, monocytes, and basic peripheral blood lymphocytes expressing TLR2, aiming at the determination of a possible correlation between the expression of TLR2 and the clinical outcomes of endometriosis in 40 patients and 40 age-matched healthy women. Our study showed the importance of TLR2 expr

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24

Janz, Siegfried. "Waldenström Macroglobulinemia: Clinical and Immunological Aspects, Natural History, Cell of Origin, and Emerging Mouse Models." ISRN Hematology 2013 (September 9, 2013): 1–25. http://dx.doi.org/10.1155/2013/815325.

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Waldenström macroglobulinemia (WM) is a rare and currently incurable neoplasm of IgM-expressing B-lymphocytes that is characterized by the occurrence of a monoclonal IgM (mIgM) paraprotein in blood serum and the infiltration of the hematopoietic bone marrow with malignant lymphoplasmacytic cells. The symptoms of patients with WM can be attributed to the extent and tissue sites of tumor cell infiltration and the magnitude and immunological specificity of the paraprotein. WM presents fascinating clues on neoplastic B-cell development, including the recent discovery of a specific gain-of-function

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25

Kuzmina, A. P., and O. M. Lazarenko. "Improving the effectiveness of teaching problematic issues of rheumatology at the stage of postgraduate education by integrating immunological knowledge." Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini 2021, no. 2 (2021): 40–44. http://dx.doi.org/10.15407/internalmed2021.02.040.

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Clinical immunology is becoming an increasingly important area, in terms of its widespread use, in the teaching of rheumatology in cycles of thematic improvement. Purpose: development of a new diagnostic and therapeutic strategy for teaching rheumatological aspects based on the use of immunological knowledge. Rheumatologists are well aware of the simultaneous identification of antibodies to nuclear and cytoplasmic antigens, which contributes to the differential diagnosis of autoimmune pathology. The three versions of the quests we compiled had ambiguous answers from specialists who were well a

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26

Filatova, E. N., L. A. Solntsev, N. B. Presnyakova, E. A. Kulova, and O. V. Utkin. "DETERMINATION OF SOME IMMUNOLOGICAL FEATURES OF HHV-6-MEDIATED INFECTIOUS MONONUCLEOSIS IN CHILDREN BY THE METHOD OF DISCRIMINATORY ANALYSIS." Russian Journal of Infection and Immunity 8, no. 2 (September 10, 2018): 223–29. http://dx.doi.org/10.15789/2220-7619-2018-2-223-229.

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Human herpesvirus type 6 (HHV-6) is a lymphotropic virus that is an etiological agent of infectious mononucleosis (IM) in children. HHV-6- mediated infectious mononucleosis (HHV-6M) does not have clearly defined clinical features. Nowadays immunopathogenetic aspects of this disease have not been fully understood. The purpose of this work was to study the characteristics of the quantitative composition of populations of immunocompetent cells of peripheral blood in children with HHV-6M. The material for the study was samples of peripheral blood from children with “infectious mononucleosis” diagn

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Kumar, Ashok, Jesus Zamora-Pineda, Emilie Degagné, and Julie D. Saba. "S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling." Mediators of Inflammation 2017 (2017): 1–19. http://dx.doi.org/10.1155/2017/7685142.

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Sphingosine-1-phosphate (S1P) is a potent lipid signaling molecule that regulates pleiotropic biological functions including cell migration, survival, angiogenesis, immune cell trafficking, inflammation, and carcinogenesis. It acts as a ligand for a family of cell surface receptors. S1P concentrations are high in blood and lymph but low in tissues, especially the thymus and lymphoid organs. S1P chemotactic gradients are essential for lymphocyte egress and other aspects of physiological cell trafficking. S1P is irreversibly degraded by S1P lyase (SPL). SPL regulates lymphocyte trafficking, infl

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Vlasova, Galina V., and Pavel V. Pavlov. "Age aspects of the course of chronic otitis media with cholesteatoma in children (clinical and immunological characteristics)." Pediatrician (St. Petersburg) 10, no. 5 (January 28, 2020): 13–18. http://dx.doi.org/10.17816/ped10513-18.

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Cholesteatoma of the middle ear is the disease, the course and prognosis of which can not be considered without taking into account the patients age. In pediatric otorhinolaryngology, such patients require special attention due to the aggressiveness of cholesteatoma in children. The rapid growth and a high number of recurrences after surgical treatment are features of the course of this disease in children. The causes of the aggressiveness of this disease in children have not been studied. Objective: to identify clinical and immunological features in children with middle ear cholesteatoma in d

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Dobrochotova, Yu E., and A. Kh Karanasheva. "Vulvovaginal candidiasis in women of reproductive age: immunological aspects of modern algorithms for examination and treatment." Meditsinskiy sovet = Medical Council, no. 16 (October 7, 2022): 57–61. http://dx.doi.org/10.21518/2079-701x-2022-16-16-57-61.

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immunological defense complex is involved: the role of complement, T-lymphocytes, NK-cells is noted. Of particular importance among immune factors is interferon-γ, which is able to limit the reproduction of Candida fungi in the early stages of infection by stimulating the immune response. This is due to the fact that interferon-γ is the strongest stimulator of effector functions of macrophages (microbicidal activity, cytokine production), increases the expression of histocompatibility molecules MHCI and MHCII, as well as adhesion molecules on endothelial cells, increasing endothelial permeabil

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Pyzik, Michal, Eve-Marie Gendron-Pontbriand, and Silvia M. Vidal. "The Impact of Ly49-NK Cell-Dependent Recognition of MCMV Infection on Innate and Adaptive Immune Responses." Journal of Biomedicine and Biotechnology 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/641702.

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Clinical and experimental data indicate that a subset of innate lymphocytes, natural killer (NK) cells, plays a crucial role in the response against herpesviruses, especially cytomegaloviruses (CMV). Indeed, in mice, NK cells, due to the expression of germline encoded Ly49 receptors, possess multiple mechanisms to recognize CMV infection. Classically, this results in NK cell activation and the destruction of the infected cells. More recently, however, this unique host-pathogen interaction has permitted the discovery of novel aspects of NK cell biology, implicating them in the regulation of ada

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Zhelavskyi, M. M. "Immunobiological aspects of cow lactation." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 21, no. 95 (November 2, 2019): 3–8. http://dx.doi.org/10.32718/nvlvet9501.

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Lactation of cows is a high-energy metabolic process. It is regulated in the body by the complex physiological mechanisms of the nervous, endocrine and immune systems. The purpose of to study changes in the immunobiological reactivity of the body of cows during lactation. Clinical and experimental studies were accomplished at the veterinary clinic and in the specialized laboratory of reproductive animal immunology. For the study, four groups of analogues of experimental animals were formed in which the immunological methods determined the immune status: cows (n = 17) during the early lactation

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Taskina, Elizaveta S., and Svetlana V. Kharintseva. "Morphofunctional characteristics and immunological regulation of the orbital fibroblasts function in endocrine ophthalmopathy." Clinical and experimental thyroidology 14, no. 4 (April 19, 2019): 183–91. http://dx.doi.org/10.14341/ket10147.

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Endocrine ophthalmopathy (EOP) is a chronic disease characterized by progressive autoimmune inflammation of the soft retrobulbar tissues in thyroid dysfunction. The orbital fibroblasts with their unique morphofunctional properties are very important in the pathogenesis of the infiltrative process and fibrosis of the extraocular muscles and/or retrobulbar tissue. They, unlike other localization fibroblasts, have not mesodermal, but neuro-ectodermal origin. The review acquaints with the immunological aspects of the regulation of these cells in different activity phases of disease. Intercellular

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Sacchetti, Benedetto, Andrea Botticelli, Luca Pierelli, Marianna Nuti, and Maurizio Alimandi. "CAR-T with License to Kill Solid Tumors in Search of a Winning Strategy." International Journal of Molecular Sciences 20, no. 8 (April 17, 2019): 1903. http://dx.doi.org/10.3390/ijms20081903.

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Artificial receptors designed for adoptive immune therapies need to absolve dual functions: antigen recognition and abilities to trigger the lytic machinery of reprogrammed effector T lymphocytes. In this way, CAR-T cells deliver their cytotoxic hit to cancer cells expressing targeted tumor antigens, bypassing the limitation of HLA-restricted antigen recognition. Expanding technologies have proposed a wide repertoire of soluble and cellular “immunological weapons” to kill tumor cells; they include monoclonal antibodies recognizing tumor associated antigens on tumor cells and immune cell checkp

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Ishchenko, O., A. Badyukov, T. Badyoukova, A. Zebentaev, and A. Valynets. "Heterogeneity of benign prostatic hyperplasia." Immunopathology, Allergology, Infectology 2022 (April 1, 2022): 45–50. http://dx.doi.org/10.14427/jipai.2022.2.45.

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Background. Benign prostatic hyperplasia (BPH) is a histologically determined condition of the male body and is characterized by glandular-stromal multi-focal proliferation originating from the paraurethral and (or) transition zone of the prostate gland. Proliferative processes in the body are under the control of the immune system. Identifying and understanding the immunological aspects of prostatic hyperplasia can help control prostate tissue growth, improving men's quality of life. The aim of our study was to conduct a pilot study, assessment of the immune status of patients with benign pro

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Patuzzo, Giuseppe, Filippo Mazzi, Antonio Vella, Riccardo Ortolani, Alessandro Barbieri, Elisa Tinazzi, Giacomo Marchi, et al. "Immunophenotypic Analysis of B Lymphocytes in Patients with Common Variable Immunodeficiency: Identification of CD23 as a Useful Marker in the Definition of the Disease." ISRN Immunology 2013 (April 4, 2013): 1–8. http://dx.doi.org/10.1155/2013/512527.

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Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by the failure of B lymphocytes differentiation leading to deficient immunoglobulins secretion. The identified genetic defects account only for a minority of cases. The importance of B cells immunophenotyping in the classification of CVID is known. This procedure can identify alterations on the cell surface molecules expression that could explain some immunological disorders characteristic of CVID. Moreover, some immunophenotypical aspects can correlate with clinical features of the disease. We used this proced

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Martínez, J. Alfredo, M. Teresa Macarulla, Rafael Marcos, and Jesús Larralde. "Nutritional outcome and immunocompetence in mice fed on a diet containing raw field beans (Vicia faba, var. minor) as the source of protein." British Journal of Nutrition 68, no. 2 (September 1992): 493–503. http://dx.doi.org/10.1079/bjn19920107.

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Feeding growing mice on diets containing raw field beans (Vicia faba var. minor) as the only source of protein brought about an impairment in growth, muscle mass and liver weight. No changes in food consumption were observed, but the food intake:weight gain ratio was increased in those animals. Plasma protein, triacylglycerols and cholesterol values were not affected by the dietary treatment although serum glucose and zinc levels fell after legume intake as well as the number of circulating erythrocytes. The relative enlargement of thymus and spleen in the legume-fed mice was apparently accomp

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Kimber, Ian, Ian Illingworth, and Marie Cumberbatch. "The Basics Immunological Aspects Direct interaction between antigen-bearing dendritic cells and T-lymphocytes during the induction phase of allergic contact dermatitis." Contact Dermatitis 23, no. 4 (October 1990): 234. http://dx.doi.org/10.1111/j.1600-0536.1990.tb05006.x.

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Merrill, L., T. E. Stewart Merrill, A. M. Barger, and T. J. Benson. "Avian Health across the Landscape: Nestling Immunity Covaries with Changing Landcover." Integrative and Comparative Biology 59, no. 5 (May 14, 2019): 1150–64. http://dx.doi.org/10.1093/icb/icz037.

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Abstract The landscape composition of an organism’s home range or territory should influence aspects of its condition, including measures of immune function. Changes in immunocompetence arising from variation in landcover may provide important links between habitat changes and patterns of disease spread. To establish a baseline understanding for whether immune measures covary with changes in landcover, we examined associations between immunological parameters and landcover composition for adults and nestlings of five shrubland bird species. Specifically, we examined the bacteria-killing abilit

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Romanishina, T. A., D. V. Feschenko, G. O. Rinyak, V. V. Honcharenko, A. A. Macibora, I. O. Kaminska, K. P. Sviridyuk, and A. P. Sviridyuk. "Pathogenetic aspects of rabbits’ experimental infection caused by bovine leukemia virus." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 22, no. 100 (December 23, 2020): 16–22. http://dx.doi.org/10.32718/nvlvet10003.

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Bovine leukemia virus (BLV) is an infectious disease of cattle, causing high economic losses worldwide, especially in the field of dairy farming. There is no common vision on the problem of interspecies transmission of BLV. Therefore, a detailed study of the etiologic relationship between leukemia in cattle and other animal species is relevant. Various laboratory animal models provide insight into the pathogenesis of viral infections. The article presents the research results of two series rabbits’ intravenous infection with bovine leukemia virus (BLV) using the culture antigen FLK-BLV and the

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Dowd, Pauline S., J. Kelleher, B. E. Walker, and P. J. Guillou. "Nutrition and cellular immunity in hospital patients." British Journal of Nutrition 55, no. 3 (May 1986): 515–27. http://dx.doi.org/10.1079/bjn19860059.

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1. The interrelations between nutritional and ccllular immune function measurements were studied in seventy patients suffering from various degrees of malnutrition. They included patients with liver disease, inflammatory bowel disease, neoplastic disease, neurological patients, post-operative surgical patients and patients with respiratory problems.2. Nutritional measurements included: anthropometry, serum proteins, various vitamins and trace elements, and a prognostic nutritional index (PNI) was calculated.3. Immunological measurements included: (1) natural killer (NK) cell activity, (2) anti

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Sijts, Alice J. A. M., Thomas Ruppert, Barbara Rehermann, Marion Schmidt, Ulrich Koszinowski, and Peter-M. Kloetzel. "Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes." Journal of Experimental Medicine 191, no. 3 (February 7, 2000): 503–14. http://dx.doi.org/10.1084/jem.191.3.503.

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Interferon (IFN)-γ–induced cells express the proteasome subunits low molecular weight protein (LMP)2, LMP7, and MECL-1 (multicatalytic endopeptidase complex–like 1), leading to the formation of immunoproteasomes. Although these subunits are thought to optimize MHC class I antigen processing, the extent of their role and the mechanistic aspects involved remain unclear. Herein, we study the proteolytic generation of an human histocompatibility leukocyte antigen (HLA)-Aw68–restricted hepatitis B virus core antigen (HBcAg) cytotoxic T lymphocyte (CTL) epitope that is recognized by peripheral blood

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Miska, Jason, Midhat H. Abdulreda, Priyadharshini Devarajan, Jen Bon Lui, Jun Suzuki, Antonello Pileggi, Per-Olof Berggren, and Zhibin Chen. "Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance." Journal of Experimental Medicine 211, no. 3 (February 24, 2014): 441–56. http://dx.doi.org/10.1084/jem.20130785.

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Real-time imaging studies are reshaping immunological paradigms, but a visual framework is lacking for self-antigen-specific T cells at the effector phase in target tissues. To address this issue, we conducted intravital, longitudinal imaging analyses of cellular behavior in nonlymphoid target tissues to illustrate some key aspects of T cell biology. We used mouse models of T cell–mediated damage and protection of pancreatic islet grafts. Both CD4+ and CD8+ effector T (Teff) lymphocytes directly engaged target cells. Strikingly, juxtaposed β cells lacking specific antigens were not subject to

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Abdul-Majeed, A. F., and S. Y. Abdul-Rahman. "IMPACT OF VITAMIN E AND SELENIUM TREATMENT IN-OVO AND AFTER HATCHING OF BROILER." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 53, no. 4 (August 30, 2022): 810–18. http://dx.doi.org/10.36103/ijas.v53i4.1593.

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This study was aimed to investigate the effect of in-ovo injection with vitamin E and selenium during the incubation and post-hatching period. 360 fertilized eggs of Ross 308 broiler breeders were incubated, then distributed on 10th day into three groups (120 eggs/group). 1st group: uninjected eggs, 2nd group: eggs were injected with 0.1 ml deionized water/egg in the chorioallantoic cavity, and 3rd group: eggs were injected with 0.1 ml/egg of Introvit-E-Selen in chorioallantoic cavity. After hatching, 270 chicks were randomly distributed into six groups, and reared until 42 days aged as follow

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Korneva, E. A., A. V. Petyaeva, T. V. Fedotkina, L. P. Churilov, and Y. Shoenfeld. "SYNOPSIS AND PROSPECTS OF AUTOIMMUNOLOGY DEVELOPMENT WORLDWIDE (AFTER THE MATERIALS OF THE 11th INTERNATIONAL CONGRESS IN LISBON, MAY 16-20, 2018). PROCEEDING I: FIRST ACADEMY OF AUTOIMMUNITY." Medical Immunology (Russia) 21, no. 1 (January 24, 2019): 171–88. http://dx.doi.org/10.15789/1563-0625-2019-1-171-188.

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A review article is an aftermath of the 11th International Congress on Autoimmunity and First Academy of Autoimmunity, happened 14th to 20th May, 2018 in Lisbon. The first part of paper discusses the formation, main problems and prospects for the development of Autoimmunology as a new integral branch of fundamental and clinical Medicine engaged in the research, diagnosis, treatment and prevention of autoimmune diseases of various organs and systems, totally circa 90 of them. A summary of all lectures conducted during the Academy of Autoimmunity is given, including a discussion of the newest an

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Limgala, Renuka P., and Ozlem Goker-Alpan. "Effect of Substrate Reduction Therapy in Comparison to Enzyme Replacement Therapy on Immune Aspects and Bone Involvement in Gaucher Disease." Biomolecules 10, no. 4 (March 31, 2020): 526. http://dx.doi.org/10.3390/biom10040526.

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Gaucher disease (GD) is caused by mutations in the GBA gene, leading to deficient activity of the lysosomal enzyme glucocerebrosidase. Among all the symptoms across various organ systems, bone disease is a major concern as it causes high morbidity and reduces quality of life. Enzyme replacement therapy (ERT) is the most accepted treatment; however, there are still unmet needs. As an alternative, substrate reduction therapy (SRT) was developed using glucosylceramide synthase inhibitors. In the current study, the effects of ERT vs. SRT were compared, particularly the immunological and bone remod

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Fujita, Tomoyuki, Atsushi Yoshida, Hajime Nishimura, Kayoko Koshikawa, Naoya Nagura, Koji Yoshida, Yasuo Miyoshi, et al. "Phase I clinical trial of multi-antigen peptide vaccines therapy using cancer-testis antigens for patients with advanced or recurrent breast cancer." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e13037-e13037. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13037.

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e13037 Background: Cancer-testis (CT) antigens are proteins that are normally expressed only in the human germline, but are also present in a significant subset of malignant tumors. The practical importance of these proteins is that, due to their restricted expression pattern, they are frequently recognized by the immune system of cancer patients. Moreover, this antigenicity has raised the possibility of their use as vaccines to stimulate immune responses in order to combat tumor growth. As a result, many aspects of CT antigens have been examined in studies performed worldwide. Here we report

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Nowak-Kornicka, Judyta, Barbara Borkowska, and Bogusław Pawłowski. "Masculinity and immune system efficacy in men." PLOS ONE 15, no. 12 (December 14, 2020): e0243777. http://dx.doi.org/10.1371/journal.pone.0243777.

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Masculinity-related morphological traits are supposed to be honest indicators of a man's biological quality. While some studies showed that sexually dimorphic traits are related to various aspects of biological condition such as general health, immunity or fertility, still little is known about the relationship between masculine traits and the effectiveness of innate and adaptive immunity in humans. The aim of this study was to see if masculine traits, which are dependent on androgen levels in foetal and pubertal stages of development, are related to the immune quality in healthy men. The immu

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Brandler, Samantha, Alice Lepelley, Marion Desdouits, Florence Guivel-Benhassine, Pierre-Emmanuel Ceccaldi, Yves Lévy, Olivier Schwartz, and Arnaud Moris. "Preclinical Studies of a Modified Vaccinia Virus Ankara-Based HIV Candidate Vaccine: Antigen Presentation and Antiviral Effect." Journal of Virology 84, no. 10 (March 10, 2010): 5314–28. http://dx.doi.org/10.1128/jvi.02329-09.

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ABSTRACT Poxvirus-based human immunodeficiency virus (HIV) vaccine candidates are currently under evaluation in preclinical and clinical trials. Modified vaccinia virus Ankara (MVA) vectors have excellent safety and immunogenicity records, but their behavior in human cell cultures remains only partly characterized. We studied here various virological and immunological aspects of the interactions of MVA-HIV, a vaccine candidate developed by the French National Agency for AIDS Research (ANRS), with primary human cells. We report that MVA-HIV infects and drives Gag expression in primary macrophag

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Kondo, Yasuteru, Masashi Ninomiya, Eiji Kakazu, Osamu Kimura, and Tooru Shimosegawa. "Hepatitis B Surface Antigen Could Contribute to the Immunopathogenesis of Hepatitis B Virus Infection." ISRN Gastroenterology 2013 (January 16, 2013): 1–8. http://dx.doi.org/10.1155/2013/935295.

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Various findings concerning the clinical significance of quantitative changes in hepatitis B surface antigen (HBsAg) during the acute and chronic phase of hepatitis B virus (HBV) infection have been reported. In addition to being a biomarker of HBV-replication activity, it has been reported that HBsAg could contribute to the immunopathogenesis of HBV persistent infection. Moreover, HBsAg could become an attractive target for immune therapy, since the cellular and humeral immune response against HBsAg might be able to control the HBV replication and life cycle. However, several reports have des

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Yolken, R. H., and E. F. Torrey. "Viruses, schizophrenia, and bipolar disorder." Clinical Microbiology Reviews 8, no. 1 (January 1995): 131–45. http://dx.doi.org/10.1128/cmr.8.1.131.

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The hypothesis that viruses or other infectious agents may cause schizophrenia or bipolar disorder dates to the 19th century but has recently been revived. It could explain many clinical, genetic, and epidemiologic aspects of these diseases, including the winter-spring birth seasonality, regional differences, urban birth, household crowding, having an older sibling, and prenatal exposure to influenza as risk factors. It could also explain observed immunological changes such as abnormalities of lymphocytes, proteins, autoantibodies, and cytokines. However, direct studies of viral infections in

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