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Дисертації з теми "Lymphomas and leukemias"

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1

Sandhu, Sukhinder K. "ROLE OF MICRORNA-155 IN B-CELL LEUKEMIAS/LYMPHOMAS." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1312400705.

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2

Walsh, Sarah. "Analysis of Immunoglobulin Genes and Telomeres in B cell Lymphomas and Leukemias." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5748.

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<p>B cell lymphomas and leukemias are heterogeneous tumors with different cellular origins. Analysis of immunoglobulin (Ig) genes enables insight into the B cell progenitor, as Ig somatic hypermutation correlates with antigen-related B cell transit through the germinal center (GC). Also, restricted Ig variable heavy chain (V<sub>H</sub>) gene repertoires in B cell malignancies could imply antigen selection during tumorigenesis. The length of telomeres has been shown to differ between GC B cells and pre/post-GC B cells, possibly representing an alternative angle to investigate B cell tumor orig
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3

Walsh, Sarah H. "Analysis of immunoglobulin genes and telomeres in B cell lymphomas and leukemias /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5748.

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4

Kwok, Suet-kei Gladys. "The effectiveness of a chemotherapy educational programme (CEP) for Leukaemia and Lymphoma patients." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972937.

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5

Chan, Wai. "Clonal rearrangement of T-cell receptor delta gene in hematological malignancies and applications in detection of minimal residual disease /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1705512X.

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6

Hovhannisyan, Narinée. "[18F] Fludarabine pour l'imagerie TEP des lymphomes." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC412/document.

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Bien que l’utilité de la TEP au [18F]FDG soit confirmée pour le diagnostic et le suivi thérapeutique chez les patients atteints de lymphome, la spécificité de la captation du [18F]FDG a été mise en doute en raison de sa dépendance au métabolisme du glucose, qui peut augmenter dans des conditions bégnines comme les processus inflammatoire ou infectieux. Compte tenu de ces limites, un nucléoside a été développé en tant que nouvel outil pour l'imagerie TEP ([18F]fludarabine). Une radiosynthèse entièrement automatisée a été mise en place et des études précliniques ont été menées sur des modèles mu
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7

Bejai, Prashanth. "Higher order spectra for the discrimination of malignant lymphomas and leukemia." Ohio : Ohio University, 2005. http://www.ohiolink.edu/etd/view.cgi?ohiou1113334700.

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8

黃傑煇 and Kit-fai Wong. "CD56-positive: natural killer cell lymphoma/leukaemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3198177X.

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9

Wong, Kit-fai. "CD56-positive natural killer cell lymphoma/leukaemia /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23736197.

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10

Cleary, Helen Julia. "Genetic analyses of radiation-induced leukaemias/lymphomas." Thesis, Brunel University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324649.

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11

Kam, Kevin. "Therapeutic potential of demethylation agents and histone deaceytlase inhibitors in NK-cell lymphoma and leukemia /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38657922.

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12

Cho, Candice. "Factors affecting stem cell transplantation for leukemia and lymphoma." CONNECT TO ELECTRONIC THESIS, 2006. http://hdl.handle.net/1961/3595.

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13

Adamson, Penelope Jane. "Engineering antibodies for use in leukemia and lymphoma therapy /." Title page, contents and summary only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09pha221.pdf.

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14

Thörn, Ingrid. "Minimal Residual Disease Assessment in Childhood Acute Lymphoblastic Leukemia." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101028.

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15

Lundin, Jeanette. "Targeted CD52 therapy in lymphoid malignancies : a clinical and immunological study /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-441-0/.

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16

Villaudy, Julien. "Challenging Development of a Humanized Mouse Model for Evaluating the HTLV-1 Infection and Leukemogenic Process in vivo." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2011. http://tel.archives-ouvertes.fr/tel-00682482.

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Анотація:
Human T-cell Leukemia Virus type 1 (HTLV-1) is the etiologic agent of the Adult T-cell Leukemia (ATL), an aggressive lymphoproliferation of activated CD4+ T cells. The lack of a reliable small animal model to reproduce in vivo the leukemogenic process associated with HTLV-1 infection has impaired the understanding of the early stages of this process as well as the discovery of effective therapeutic approaches. Recently, improvement in the models of humanized mouse models were achieved allowing the development of a human immune system in mice. Injection of human hematopoietic stem and progenito
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17

Johansson, Ann-Sofie. "Establishment and characterization of a murine T-cell lymphoma/leukemia model." Doctoral thesis, Umeå universitet, Institutionen för strålningsvetenskaper, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35195.

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Mouse models of human disease are valuable tools for studying pathogenesis and for evaluating novel therapies. T-cell lymphoma is a relatively rare disease in humans, affecting 100-150 persons yearly in Sweden. It exists in both aggressive and more indolent forms. We have established a mouse model for an aggressive T-cell lymphoma, the T-cell lymphoma/leukemia (TLL) mouse. In the present thesis, the TLL mouse model was characterized and used for experimental therapeutic and primary prevention studies. The TLL mouse was established unintentionally in our laboratory during work on VH-gene replac
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18

Kwok, Suet-kei Gladys, and 郭雪琪. "The effectiveness of a chemotherapy educational programme (CEP) for Leukaemia and Lymphoma patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972937.

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19

Halldórsdóttir, Anna Margrét. "Genetic and Epigenetic Profiling of Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia." Doctoral thesis, Uppsala universitet, Hematologi och immunologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156786.

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Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) both belong to the group of mature B-cell malignancies. However, MCL is typically clinically aggressive while the clinical course of CLL varies. CLL can be divided into prognostic subgroups based on IGHV mutational status and into multiple subsets based on closely homologous (stereotyped) B-cell receptors. In paper I we investigated 31 MCL cases using high-density 250K single-nucleotide polymorphism arrays and gene expression arrays. Although most copy-number aberrations (CNAs) were previously reported in MCL, a novel deletion w
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20

Kohart, Nicole Ann Kohart. "Models, Mechanisms, and Treatment of Adult T-cell Leukemia/Lymphoma Bone Metastasis." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503248777003095.

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21

Kam, Kevin, and 甘季燐. "Therapeutic potential of demethylation agents and histone deaceytlase inhibitors in NK-cell lymphoma and leukemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011564.

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22

Rapino, Francesca 1982. "Induced transdifferentiation of human B-leukemia/lymphoma cell lines and inhibition of leukemogenicity." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/128575.

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Анотація:
B-cell malignancies encompass a wide variety of distinct diseases including Non Hodgkin lymphoma (NHL) and leukemia. Currently, chemotherapy, radiation and anti-CD20 antibody treatment are the mainstays of B-cell lymphoma and leukemia therapy. However, the fact that a large number of patients are eventually not cured justifies the search for novel and more effective therapeutic approaches. Although induction of differentiation has been shown to be effective in several tumors such as acute promyelocytic leukemia, it has not been tested yet in NHL and leukemia. We therefore hypothesized
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23

陳衛 and Wai Chan. "Clonal rearrangement of T-cell receptor delta gene in hematological malignancies and applications in detection of minimal residualdisease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31212852.

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24

Thorsélius, Mia. "Immunoglobulin gene analysis in different B cell lymphomas : with focus on cellular origin and antigen selection /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4567.

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25

Bishop, Michael W. M. D. "Therapy-Related Events and Health-Related Quality of Life for Children with Leukemia and Lymphoma." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544150.

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26

Schuler, Aaron D. "Development of sirtuin and calmodulin-dependent protein kinase inhibitors as anti-cancer therapeutics /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8491.

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27

Kennah, Erin. "Identification of differentially expressed genes in AHI-1-mediated leukemic transformation in cutaneous t-cell lymphoma." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/962.

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The oncogene Ahi-1 was recently identified through provirus insertional mutagenesis in murine leukemias and lymphomas. Its involvement in human leukemogenesis is demonstrated by gross perturbations in its expression in several leukemic cells lines, particularly in cutaneous T-cell lymphoma (CTCL) cell lines (Hut 78 and Hut 102). Hut 78 is derived from a patient with Sezary syndrome, a common leukemic variant of the human CTCL mycosis fungoides. Aberrant expression of AHI-1 mRNA and protein has been found in CD4⁺CD7⁻ leukemic Sezary cells from patients with Sezary syndrome. Moreover, stable
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28

Liu, Qing. "Targeting Protein Phosphatase 2a as a Therapeutic Strategy for Chronic Lymphocytic Leukemia." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1213301219.

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29

Rosilio, Célia. "Recherche de nouvelles stratégies thérapeutiques ciblant le métabolisme des cellules cancéreuses à l'aide d'un modèle murin de lymphome T déficient pour PTEN." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4047.

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Les leucémies aiguës lymphoblastiques et les lymphomes de type T sont des cancers très agressifs, génétiquement hétérogènes. Les pronostics sont globalement défavorables et la survie après rechute n’est que de 10%. Les plus fréquentes mutations ont pour conséquence l’activation constitutive de l’axe PI3K/AKT/mTOR favorisant la progression tumorale. La compréhension des mécanismes de la transformation cancéreuse, à l’aide d’un modèle murin (invalidation spécifique de PTEN dans les lymphocytes T), va permettre de proposer de nouvelles cibles potentielles et de futurs traitements ciblés qui peuve
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30

Matas, Céspedes Alba. "Innovative therapies targeting tumor-microenvironment crosstalk in indolent B-cell non-Hodgkin lymphomas." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/401756.

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Follicular Lymphoma (FL) and Chronic Lymphocytic Leukemia (CLL) share several features in common: 1) they are indolent B-cell neoplasms, 2) patients usually relapse after treatment, 3) both pathologies as yet remain incurable. The initial driving event in both malignancies is the early acquisition of genetic alterations; however, the proliferative drive for malignant cells is largely dependent on external signals from the tumor microenvironment, which favor the survival of malignant cells. For this reason, the main aim of this thesis was to explore new therapies targeting the interactions betw
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31

Jurinovic, Vindi [Verfasser], and Ulrich [Akademischer Betreuer] Mansmann. "Risk prediction for patients with follicular lymphoma and chronic lymphocytic leukemia / Vindi Jurinovic ; Betreuer: Ulrich Mansmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1160875820/34.

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32

Nabbouh, Ali. "Effet de l’Imiquimod et de composés dérivés EAPB0203 et EAPB0503 sur des modèles de leucémies et de lymphomes." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONT3519/document.

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La leucémie myéloïde aiguë (LMA) est une maladie clonale hétérogène caractérisée par une prolifération immature des cellules myéloïdes et une défaillance de la moelle osseuse. Malgré les avancées rapides dans le domaine de la LMA, notamment concernant de nouvelles cibles thérapeutiques et une meilleure compréhension des mécanismes biologiques, le traitement clinique de la LMA reste inchangé et dépend du caryotype des patients. Lors des trois dernières décennies, la plupart des patients ont fini par récidiver et décéder de la maladie ; il n’y a encore aucun schéma thérapeutique standard qui amé
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33

Mitagami, Yu. "Interferon-γ promotes inflammation and development of T-cell lymphoma in HTLV-1 bZIP factor transgenic mice". Kyoto University, 2016. http://hdl.handle.net/2433/215454.

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34

Rosilio, Célia. "Recherche de nouvelles stratégies thérapeutiques ciblant le métabolisme des cellules cancéreuses à l'aide d'un modèle murin de lymphome T déficient pour PTEN." Electronic Thesis or Diss., Nice, 2014. http://www.theses.fr/2014NICE4047.

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Анотація:
Les leucémies aiguës lymphoblastiques et les lymphomes de type T sont des cancers très agressifs, génétiquement hétérogènes. Les pronostics sont globalement défavorables et la survie après rechute n’est que de 10%. Les plus fréquentes mutations ont pour conséquence l’activation constitutive de l’axe PI3K/AKT/mTOR favorisant la progression tumorale. La compréhension des mécanismes de la transformation cancéreuse, à l’aide d’un modèle murin (invalidation spécifique de PTEN dans les lymphocytes T), va permettre de proposer de nouvelles cibles potentielles et de futurs traitements ciblés qui peuve
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35

Beiggi, Sara. "Epidemiological study of chronic lymphocytic leukemia (CLL) in the province of Manitoba, Canada." British Journal of Cancer (Nature Group), 2013. http://hdl.handle.net/1993/23508.

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A previous population-based study of survival in Chronic Lymphocytic Leukemia (CLL) patients in the province of Manitoba demonstrated a lower five-year relative survival among CLL patients compared with the age- and gender-adjusted general population. This decreased relative survival was most pronounced among elderly male CLL patients. In this study, we have demonstrated that the reduced five-year relative survival observed in CLL patients compared to the general population of Manitoba may partially be attributed to increased risk of second cancers and non-referral to specialized CLL clinics
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36

Davis, Jonathan. "Cancer risk in children of agricultural health study participants." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5926.

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This study examines the risk of cancer in children of pesticide applicators from the Agricultural Health Study. The study includes 36,537 children of Iowa participants who were evaluated for cancer incidence during 1975 through 2013 from birth through the age of seventeen. Standard incidence rates for any cancer and specific groups of cancers classified using the International Classification of Childhood Cancer was calculated using rates from the general population of Iowa controlling for year of follow, age, sex, and race. Hazard ratios for Group I-III cancers and paternal exposure to specifi
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37

Tesell, Jessica M. "The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation." eScholarship@UMMS, 2013. http://escholarship.umassmed.edu/gsbs_diss/671.

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Although cure rates have significantly improved for children with T-cell acute lymphoblastic leukemia (T-ALL), 20-30% undergo induction failure or relapse with most succumbing to disease. Leukemia-initiating cells (L-ICs) are hypothesized to be resistant to conventional chemotherapy and radiation and are thereby responsible for disease recurrence. Using an in vivo limiting dilution assay, we previously showed that the murine T-ALL L-IC is quite rare, with only 0.003-0.05% of cells capable of initiating disease, and demonstrated that the L-IC is a subset of the leukemic DN3 thymic progenitor po
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38

Akers, Stephen Matthew. "Modeling central nervous system involvement in acute lymphoblastic leukemia." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/11227.

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Анотація:
Thesis (Ph. D.)--West Virginia University, 2010.<br>Title from document title page. Document formatted into pages; contains x, 102 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
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39

Cortese-Peske, Marisa A. "Improving Cultural Competency and Disease Awareness Among Oncology Nurses Caring for Adult T-Cell Leukemia and Lymphoma Patients." Thesis, Icahn School of Medicine at Mount Sinai, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3560778.

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<p> Foreign-born residents face significant challenges accessing and receiving quality healthcare in the U.S. These obstacles include a lack of information on how to access care, fear, as well as communication and cultural barriers (Portes, Fernandez-Kelly &amp; Light, 2012). Increasing healthcare providers' knowledge regarding a patient's culture as well as endemic rare diseases can serve to reassure and assuage patient discomfort. However, studies focused on educating healthcare providers regarding rare diseases that are restricted to or predominantly found in culturally distinct populations
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40

Tidwell, Jerithea Doronice d. 1972. "Sleep, fatigue and caregiver burden in parents of children with acute lymphoblastic leukemia (ALL)." View the abstract Download the full-text PDF version (on campus access only), 2008. http://etd.utmem.edu/ABSTRACTS/2008-004-Tidwell-Index.html.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2008<br>Title from title page screen (viewed on June 19, 2008). Research advisor: Pamela S. Hinds RN, Ph.D. Document formatted into pages (viii, 185 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 86-98).
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41

Bagalb, Hussein Saeed. "Cellular and molecular biological studies of a retroviral induced lymphoma transmitted via breast milk in a mouse model." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1225294363.

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Анотація:
Thesis (M.S.)--University of Toledo, 2008.<br>"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: pages 82-88, 111-116.
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42

BOZZER, SARA. "Preclinical development of targeted-nanoparticles for the treatment of pediatric B-cell malignancies Acute Lymphoblastic Leukemia and Burkitt Lymphoma." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3030999.

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I tumori delle cellule B sono un gruppo eterogeneo di patologie per le quali le opzioni terapeutiche includono chemioterapia e immunoterapia. Nonostante il recente sviluppo di nuove strategie terapeutiche, la maggior parte dei pazienti, tuttavia, sviluppa resistenze o non risponde alle terapie. L'obiettivo di questo progetto di dottorato è, pertanto, lo sviluppo preclinico di un nuovo strumento terapeutico per il trattamento delle neoplasie pediatriche a cellule B. In primo luogo sono state caratterizzate le nanobolle di chitosano (NBs) caricate con AntagomiR-17, sui è stato legato un anticorp
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43

LETTIERI, ANTONELLA. "Genomic and trascriptomic analyses of pediatric T-cell lynphoblastic leukemia/limphoma." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/20246.

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ABSTRACT In the first part of our work we focused our attention on the biological question about the differences between two pathologies: T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma. These two diseases share many features such as immunophenotypic features, lymphoblast morphology and clinical characteristics and are differentially diagnosed only on the base of bone marrow involvement. We tried to understand whether T-cell leukemia and lymphoma are a unique pathology with a different manifestation or whether they are two different diseases. The results obtained by gene expr
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44

Alexander, Lou-Ella M. m. "Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7119.

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The studies presented in this dissertation establish the dynamics of Eleven nineteen Lysine-rich leukemia (ELL) family of elongation factors during B cell differentiation and provide a description of ELL3 function in B cells. The transition from a mature naïve B cells into an activated B cell is dependent on a large increase in transcriptional output, which is followed by focused expression on secreted immunoglobulin upon terminal differentiation into plasma cell. While ELL family members have previously been implicated in alternative splicing at the immunoglobulin heavy chain locus in plasma
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45

Maharry, Kati S. "Risk Factors for Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Incidence in Postmenopausal Women: a Women’s Health Initiative (WHI) Study." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460981460.

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46

Rezanka, Louis J. "cDNA cloning and analysis of the feline T-cell receptor beta gene (TCR-[beta]) with special reference to feline leukemia virus-associated lymphomas /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487687485810901.

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Malone, Michael Harold. "Using Gene Expression Profiling to Understand the Mechanism of Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1112296162.

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ALLARD, LEE RICHARD. "EXPOSURE TO LOW-LEVEL IONIZING RADIATION AND RISK OF LEUKEMIA AND NON-HODGKIN'S LYMPHOMA IN PARTICIPANTS OF THE FERNALD MEDICAL MONITORING PROGRAM." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1141071821.

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Feltenmark, Stina. "Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells." Stockholm : Division of Physiological Chemistry II, Karolinska Institutet, 2010. http://diss.kib.ki.se/2010/978-91-7409-745-0/.

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